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https://www.readbyqxmd.com/read/28110264/novel-phyto-derivative-brm270-inhibits-hepatocellular-carcinoma-cells-proliferation-by-inducing-g2-m-phase-cell-cycle-arrest-and-apoptosis-in-xenograft-mice-model
#1
Raj Kumar Mongre, Neelesh Sharma, Simrinder Singh Sodhi, Mrinmoy Ghosh, Amit Kumar Singh, Nameun Kim, Yang Ho Park, Young Gyu Shin, Sung Jin Kim, Zhang Jiao Jiao, Do Luong Huynh, Dong Kee Jeong
Hepatocellular carcinoma (HCC) is a major threat to human health worldwide and development of novel antineoplastic drug is demanding task. BRM270 is a proprietary combination of traditional medicinal herbs, has been shown to be effective against a wide range of stem-like cancer initiating cells (SLCICs). However, the underlying mechanism and antitumor efficacy of BRM270 in human hepatocellular carcinoma (HCC) cells have not been well elucidated till date. Here we studied the tumoricidal effect of BRM270 on human-CD133(+) expressing stem-like HepG-2 and SNU-398 cells...
January 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28110063/curcumin-ameliorates-liver-damage-and-progression-of-nash-in-nash-hcc-mouse-model-possibly-by-modulating-hmgb1-nf-%C3%AE%C2%BAb-translocation
#2
Rejina Afrin, Somasundaram Arumugam, Azizur Rahman, Mir Imam Ibne Wahed, Vengadeshprabhu Karuppagounder, Meilei Harima, Hiroshi Suzuki, Shizuka Miyashita, Kenji Suzuki, Hiroyuki Yoneyama, Kazuyuki Ueno, Kenichi Watanabe
Curcumin, a phenolic compound, has a wide spectrum of therapeutic effects such as antitumor, anti-inflammatory, anti-cancer and so on. The study aimed to investigate the underlying mechanisms of curcumin to protect liver damage and progression of non-alcoholic steatohepatitis (NASH) in a novel NASH-hepatocellular carcinoma (HCC) mouse model. To induce this model neonatal C57BL/6J male mice were exposed to low-dose streptozotocin and were fed a high-fat diet (HFD) from the age of 4weeks to 14weeks. Curcumin was given at 100mg/kg dose daily by oral gavage started at the age of 10weeks and continued until 14weeks along with HFD feeding...
January 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28110040/doxorubicin-and-paclitaxel-co-bound-lactosylated-albumin-nanoparticles-having-targetability-to-hepatocellular-carcinoma
#3
Le Quang Thao, Changkyu Lee, Bomi Kim, Sungin Lee, Tae Hwan Kim, Jong Oh Kim, Eun Seong Lee, Kyung Taek Oh, Han-Gon Choi, Sun Dong Yoo, Yu Seok Youn
Anticancer drug targeting to liver asialoglycoprotein receptors (ASGPR) is viewed as a good approach for hepatocellular carcinoma (HCC) treatment. Lactose residue is a promising ASGPR ligand due to its high receptor affinity. Herein, we introduce doxorubicin and paclitaxel co-bound lactosylated albumin (Lac-BSA) nanoparticles (Dox/Pac Lac-BSA NPs) with good liver targetability. Lac-BSA was synthesized by conjugating lactobionic acid to naïve BSA then characterized by mass spectrometry. Dox/Pac Lac-BSA NPs were fabricated utilizing high-pressure homogenization and evaporation with Nab(®) (nanoparticle albumin bound) technology...
January 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28109948/design-and-synthesis-of-novel-tetrandrine-derivatives-as-potential-anti-tumor-agents-against-human-hepatocellular-carcinoma
#4
Junjie Lan, Ning Wang, Lan Huang, Yazhou Liu, Xiaopan Ma, Huayong Lou, Chao Chen, Yibin Feng, Weidong Pan
Tetrandrine, a lead anti-tumor compound with a bis-benzyltetrahydroisoquinoline skeleton isolated from medicinal plant Stephania tetrandra. In order to obtain active anti-tumor agents and evaluate their structure-activity relationships, a series of novel tetrandrine derivatives were designed and synthesized in this study. Their anti-tumor activities against human hepatocellular carcinoma cell lines (HMCC97L and PLC/PRF/5) were also evaluated. The bioassay results showed that the derivatives exhibited moderate to strong inhibition against the two cell lines...
January 7, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28109867/interactions-between-interleukin-6-and-myeloid-derived-suppressor-cells-drive-the-chemoresistant-phenotype-of-hepatocellular-cancer
#5
Min Xu, Zhongwei Zhao, Jingjing Song, Xilin Lan, Siming Lu, Minjiang Chen, Zufei Wang, Weiqian Chen, Xiaoxi Fan, Fazong Wu, Li Chen, Jianfei Tu, Jiansong Ji
Emerging evidence implicates an important role for myeloid-derived suppressor cells (MDSCs) in tumor growth, angiogenesis and metastasis. However, limited knowledge is known about the function of MDSCs in response to chemotherapies. In this study, we find that drug-resistant hepatocellular cancer (HCC) cells-derived conditioned medium significantly enhances the expansion and immunosuppressive function of MDSCs compared to their parental sensitive cells, which is demonstrated by increased level of arginase, nitric oxide (NO), and reactive oxygen species (ROS)...
January 18, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28109767/thromboelastometry-hypercoagulable-profiles-and-portal-vein-thrombosis-in-cirrhotic-patients-with-hepatocellular-carcinoma
#6
Alberto Zanetto, Marco Senzolo, Alessandro Vitale, Umberto Cillo, Claudia Radu, Francesca Sartorello, Luca Spiezia, Elena Campello, Kryssia Rodriguez-Castro, Alberto Ferrarese, Fabio Farinati, Patrizia Burra, Paolo Simioni
BACKGROUND: Cirrhotic patients with hepatocellular carcinoma (HCC) exhibit hypercoagulability. AIM: We investigated whether thromboelastometry can detect hypercoagulability in these patients and the association with portal vein thrombosis (PVT). METHODS: At baseline, cirrhotic patients with and without HCC underwent thromboelastometry. PVT onset was recorded over a 12-month follow-up period. RESULTS: Seventy-six patients (41 with and 35 without HCC) were included...
December 26, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28109738/hepatitis-c-virus-reactivation-due-to-antiemetic-steroid-therapy-during-treatment-of-hepatocellular-carcinoma
#7
Yutaka Kawano, Koji Miyanishi, Satoshi Takahashi, Tomohiro Kubo, Kazuma Ishikawa, Shintaro Sugita, Kohichi Takada, Masayoshi Kobune, Tadashi Hasegawa, Junji Kato
Hepatitis C virus (HCV) reactivation is relatively rare compared with hepatitis B reactivation in patients treated with immunosuppressive or anticancer drugs. Here, we present the first case of genotype 2 HCV reactivation due to antiemetic steroid therapy during chemotherapy for hepatocellular carcinoma (HCC), which was verified by not only increased viral load but also pathological exacerbation of liver injury during HCV reactivation. Further chemotherapy for HCC could be continued without steroid therapy...
January 18, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28109728/the-utility-of-hair-cortisol-concentrations-in-the-prediction-of-ptsd-symptoms-following-traumatic-physical-injury
#8
Maria L Pacella, Bryce Hruska, Susann Steudte-Schmiedgen, Richard L George, Douglas L Delahanty
RATIONALE: Although cortisol alterations have been associated with posttraumatic stress disorder (PTSD) and PTSD symptoms (PTSS), the direction of association is mixed. Cortisol which is measured in blood, saliva, or urine is subject to transient factors that may confound results. Recent advances in cortisol sampling techniques provide novel opportunities to address these inconsistencies. Hair cortisol sampling is a non-invasive method for the retrospective assessment of long-term integrated cortisol, yet its utility at predicting PTSS has not been assessed in acute injury victims...
January 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28109724/the-role-of-cone-beam-ct-in-transcatheter-arterial-chemoembolization-for-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#9
Leland Pung, Moiz Ahmad, Kerstin Mueller, Jarrett Rosenberg, Christopher Stave, Gloria L Hwang, Rajesh Shah, Nishita Kothary
PURPOSE: To review available evidence for use of cone-beam CT during transcatheter arterial chemoembolization in hepatocellular carcinoma (HCC) for detection of tumor and feeding arteries. MATERIALS AND METHODS: Literature searches were conducted from inception to May 15, 2016, in PubMed (MEDLINE), Scopus, and Cochrane Central Register of Controlled Trials. Searches included "cone beam," "CBCT," "C-arm," "CACT," "cone-beam CT," "volumetric CT," "volume computed tomography," "volume CT," AND "liver," "hepatic*," "hepatoc*...
January 18, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28109674/single-center-nonrandomized-clinical-trial-to-assess-the-safety-and-efficacy-of-irreversible-electroporation-ire-ablation-of-liver-tumors-in-humans-short-to-mid-term-results
#10
P Frühling, A Nilsson, F Duraj, U Haglund, A Norén
INTRODUCTION: A single-center nonrandomized clinical trial was performed to assess the safety and efficacy of IRE ablation of liver tumors in humans. METHODS: 38 malignant liver tumors on 30 patients were treated with IRE between September 2011 and September 2014. Treatment was with curative intent, and the diagnoses were colorectal cancer with liver metastases (CRLM) (n = 23), hepatocellular carcinoma (HCC) (n = 8) and other metastasis (n = 7). Patients were selected when surgery, radiofrequency ablation (RFA) or microwave ablation (MWA) was not an option, and when they met inclusion criteria (tumor size < 3 cm, 1-2 tumors)...
January 11, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28109531/diffusion-weighted-imaging-dwi-of-hepatocellular-carcinomas-a-retrospective-analysis-of-the-correlation-between-qualitative-and-quantitative-dwi-and-tumour-grade
#11
T Jiang, J H Xu, Y Zou, R Chen, L R Peng, Z D Zhou, M Yang
AIM: To evaluate the application of qualitative and quantitative diffusion-weighted imaging (DWI) in predicting the histological grade of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Two hundred and fifty-four patients with pathologically confirmed HCC who underwent hepatic DWI on a 1.5-T platform (b = 0, 600 s/mm(2)) were evaluated retrospectively. HCCs were divided into well-, moderately, and poorly differentiated groups. The relationships between naked-eye signal intensity (SI), SI values, apparent diffusion coefficient (ADC) values on DWI, and the histopathological differentiation of HCC were analysed...
January 19, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28109115/-research-progress-of-mirnas-targeting-gsk-3%C3%AE-in-regulation-of-hepatocellular-carcinoma-invasion-and-metastasis
#12
Song-Qi He, Bin Wen, Guan-Xin Chen, Hai-Tao Sun, Jia-Ling Sun, Xue-Mei Yang
Invasion and metastasis are key factors contributing to the high mortality rate of patients with hepatocellular carcinoma (HCC) involving a complex mechanism. In the invasion and metastasis of HCC, miRNAs can serve as either oncogenes or tumor suppressor genes to regulate the differentiation and proliferation of tumor cells being and play important roles in tumorigenesis, angiogenesis, invasion and metastasis. This review summarizes the recent progress in research of the molecular mechanisms by which miRNAs targeting GSK-3β regulate HCC invasion and metastasis and examines the roles of miRNAs in hepatocellular carcinoma cell proliferation, apoptosis, invasion, metastasis, and GSK-3β regulation...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28109025/immune-regulation-by-t-regulatory-cells-in-hbv-related-inflammation-and-cancer
#13
REVIEW
Nirupama Trehanpati, Ashish Kumar Vyas
Hepatocellular carcinoma (HCC) is the leading cause of cancer death and hepatitis B virus (HBV) infection is one of the commonest causes in Asians countries. India has the second largest pool after China for hepatitis B infected subjects. HBV clearance is T cell dependent and one of the reason for T cells hypo responsiveness is due to mass production of Tregs through activation of Notch signaling, which suppressCD4/CD8 T cells. Regulatory T cells (Tregs) are important to maintain cellular homeostasis; however during viral infection increase of Tregs is inversely proportional to HBV DNA titers...
January 21, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28109005/the-mboat7-variant-rs641738-increases-inflammation-and-fibrosis-in-chronic-hepatitis-b
#14
Khaled Thabet, Henry Lik Yuen Chan, Salvatore Petta, Alessandra Mangia, Thomas Berg, Andre Boonstra, Willem P Brouwer, Maria Lorena Abate, Vincent Wai-Sun Wong, Maiiada Nazmy, Janett Fischer, Christopher Liddle, Jacob George, Mohammed Eslam
Chronic hepatitis B (CHB) is characterized by hepatic inflammation that promotes progression to cirrhosis and predisposes to the development of hepatocellular carcinoma (HCC). Subtle inter-individual genetic variation, viral and environmental factors interact to determine the disease progression between individuals. Recently, the rs641738 Membrane Bound O-Acyltransferase Domain Containing 7 (MBOAT7) polymorphism was demonstrated to influence histological liver damage in alcoholic liver disease, nonalcoholic fatty liver disease and hepatitis C, but no data are available for CHB...
January 20, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28108733/systematic-analysis-of-molecular-mechanisms-for-hcc-metastasis-via-text-mining-approach
#15
Cheng Zhen, Caizhong Zhu, Haoyang Chen, Yiru Xiong, Junyuan Tan, Dong Chen, Jin Li
OBJECTIVE: To systematically explore the molecular mechanism for hepatocellular carcinoma (HCC) metastasis and identify regulatory genes with text mining methods. RESULTS: Genes with highest frequencies and significant pathways related to HCC metastasis were listed. A handful of proteins such as EGFR, MDM2, TP53 and APP, were identified as hub nodes in PPI (protein-protein interaction) network. Compared with unique genes for HBV-HCCs, genes particular to HCV-HCCs were less, but may participate in more extensive signaling processes...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28108675/paired-assessment-of-liver-telomere-lengths-in-hepatocellular-cancer-is-a-reliable-predictor-of-disease-persistence
#16
Wen-Du Feng, De-Cai Yu, Xian-Biao Shi, Bing-Hua Li, Ou-Yang Luo, Chen Yan, Yi-Tao Ding
In the present study, we used a small series of highly defined patients, where we had matched timed peripheral blood samples, as well as paired liver biopsies obtained during collection of blood samples from patients with diagnosed hepatocellular carcinoma (HCC) and compared the correlation between the changes of telomere lengths in these defined samples. Patients included had either HCC alone or in conjunction with either pre-existing hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. PCR-based assay incorporating primers to the telomeric hexamer repeats to polymerize and detect telomeric DNA was used...
January 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28108381/metabolomic-study-of-the-intervention-effects-of-shuihonghuazi-formula-a-traditional-chinese-medicinal-formulae-on-hepatocellular-carcinoma-hcc-rats-using-performance-hplc-esi-tof-ms
#17
Yongrui Bao, Shuai Wang, Xinxin Yang, Li Tianjiao, Mingyue Xia, Xiansheng Meng
ETHNOPHARMACOLOGICAL RELEVANCE: Metabolomics is the comprehensive assessment of endogenous metabolites of a biological system in a holistic context, and its property consists with the global view of Traditional Chinese Medicine (TCM). Shuihonghuazi Formula (SHHZF) has been used for liver cancer early treatment in clinical for more than thirty years, but its mechanism remains unclear completely. This paper was designed to explore the therapeutic effects of SHHZF on liver cancer and its metabolomic characters...
January 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28107896/cortisol-levels-in-hair-are-altered-in-irritable-bowel-syndrome-a-case-control-study-in-primary-care
#18
A-K Norlin, S Walter, E Theodorsson, V Tegelstrom, E Grodzinsky, M P Jones, Å Faresjö
OBJECTIVE: Stress is an important component in the pathophysiology of irritable bowel syndrome (IBS). Long term Hypothalamus Pituitary Adrenal (HPA)-axis activity can be studied by measuring hair cortisol concentrations (HCC). Some previous studies have indicated a dysregulated HPA-axis in IBS patients, but cortisol levels in hair have not yet been studied. We investigated whether HCC and self-reported stress differentiate IBS patients from controls. METHODS: In a cross-sectional study within 10 Swedish Primary Health Care Centers we compared patients in working age with active IBS to patients without GI complaints...
February 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28107418/nf-kappab-is-involved-in-the-regulation-of-emt-genes-in-breast-cancer-cells
#19
Bruno R B Pires, Andre L Mencalha, Gerson M Ferreira, Waldemir F de Souza, José A Morgado-Díaz, Amanda M Maia, Stephany Corrêa, Eliana S F W Abdelhay
The metastatic process in breast cancer is related to the expression of the epithelial-to-mesenchymal transition transcription factors (EMT-TFs) SNAIL, SLUG, SIP1 and TWIST1. EMT-TFs and nuclear factor-κB (NF-κB) activation have been associated with aggressiveness and metastatic potential in carcinomas. Here, we sought to examine the role of NF-κB in the aggressive properties and regulation of EMT-TFs in human breast cancer cells. Blocking NF-κB/p65 activity by reducing its transcript and protein levels (through siRNA-strategy and dehydroxymethylepoxyquinomicin [DHMEQ] treatment) in the aggressive MDA-MB-231 and HCC-1954 cell lines resulted in decreased invasiveness and migration, a downregulation of SLUG, SIP1, TWIST1, MMP11 and N-cadherin transcripts and an upregulation of E-cadherin transcripts...
2017: PloS One
https://www.readbyqxmd.com/read/28107416/validation-of-a-modified-child-turcotte-pugh-classification-system-utilizing-insulin-like-growth-factor-1-for-patients-with-hepatocellular-carcinoma-in-an-hbv-endemic-area
#20
Dong Hyeon Lee, Jeong-Hoon Lee, Yong Jin Jung, Jungsoo Gim, Won Kim, Byeong Gwan Kim, Kook Lae Lee, Yuri Cho, Jeong-Ju Yoo, Minjong Lee, Young Youn Cho, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon
BACKGROUND: Recently, a modified insulin-like growth factor-1 (IGF)-Child-Turcotte-Pugh (CTP) classification was proposed to improve the original CTP classification. This study aimed to validate the new IGF-CTP classification system as a prognostic maker for patients with hepatocellular carcinoma (HCC) in a hepatitis B virus endemic area. METHODS: We conducted a post-hoc analysis of a prospective cohort study. We used Harrell's C-index and U-statistics to compare the prognostic performance of both IGF-CTP and CTP classifications for overall survival...
2017: PloS One
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