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https://www.readbyqxmd.com/read/28449505/pulmonary-vein-stump-thrombosis-after-left-pneumonectomy-diagnosed-based-on-a-high-plasma-d-dimer-level-a-case-report
#1
Tomohiro Kamori, Gouji Toyokawa, Tatsuro Okamoto, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Kazuki Takada, Masakazu Katsura, Fumihiro Shoji, Yoshihiko Maehara
A 69-year-old man with locally advanced squamous cell lung cancer in the left hilum underwent left upper sleeve lobectomy following neoadjuvant chemoradiotherapy with an S-1/cisplatin regimen. On postoperative day (POD) 5, the chest X-ray findings deteriorated, and computed tomography (CT) images showed pulmonary congestion of the left residual lung. We then performed emergent left completion pneumonectomy. Although the Postoperative course after re-operation was uneventful, and the patient was scheduled to be discharged on POD 12 when the serum creatinine level and plasma D-dimer level increased to 1...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449057/the-streptomyces-master-regulator-bldd-binds-c-di-gmp-sequentially-to-create-a-functional-bldd2-c-di-gmp-4-complex
#2
Maria A Schumacher, Wenjie Zeng, Kim C Findlay, Mark J Buttner, Richard G Brennan, Natalia Tschowri
Streptomyces are ubiquitous soil bacteria that undergo a complex developmental transition coinciding with their production of antibiotics. This transition is controlled by binding of a novel tetrameric form of the second messenger, 3΄-5΄ cyclic diguanylic acid (c-di-GMP) to the master repressor, BldD. In all domains of life, nucleotide-based second messengers allow a rapid integration of external and internal signals into regulatory pathways that control cellular responses to changing conditions. c-di-GMP can assume alternative oligomeric states to effect different functions, binding to effector proteins as monomers, intercalated dimers or, uniquely in the case of BldD, as a tetramer...
April 26, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28448884/antiproliferative-hydroxy-fatty-acids-from-the-fodder-legume-stylosanthes-guianensis
#3
Marco Clericuzio, Bruno Burlando, Barbara Borghesi, Annalisa Salis, Gianluca Damonte, Stefania Ribulla, Laura Cornara
Stylosanthes guianensis is a fodder legume native from South America and widely grown worldwide. Dried plant material was purchased on the web and taxonomically identified by light and SEM microscopy, and morphological analysis of plants germinated from seeds. The plant was extracted with dichloromethane:2-propanol (9:1). Bioguided fractionation using calcein-AM cytotoxicity assay on HeLa and A431 tumor cells allowed to isolate a lipophilic fraction, endowed with strong cytotoxicity. By means of 1- and 2-D NMR, HPLC-MS, and HR-ESIMS it could be seen that the fraction was an inseparable mixture of complex lipids, mainly consisting of esterified 3-hydroxy fatty acids...
April 17, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28447414/review-of-d-dimer-testing-good-bad-and-ugly
#4
REVIEW
L-A Linkins, S Takach Lapner
D-dimer assays are commonly used in clinical practice to exclude a diagnosis of deep vein thrombosis or pulmonary embolism. More recently, they have been also been used to guide patients with unprovoked venous thromboembolism (VTE) when faced with the decision to continue or stop anticoagulation after initial treatment is complete. D-dimer assays vary widely with respect to the antibody used, method of capture, instrumentation required, and calibration standard. These differences have an important influence on the operating characteristics of the assays...
May 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28447346/a-charge-equilibration-formalism-for-treating-charge-transfer-effects-in-md-simulations-application-to-water-clusters
#5
Sudipta Kumar Sinha, Mohit Mehta, Sandeep Patel
Conventional classical force fields by construction do not explicitly partition intermolecular interactions to include polarization and charge transfer effects, whereas fully quantum mechanical treatments allow a means to effect this dissection (although not uniquely due to the lack of a charge transfer operator). Considering the importance of polarization in a variety of systems, a particular class of classical models, charge equilibration models, have been extensively developed to study those systems; since these types of interaction models are inherently based on movement of charge throughout a system, they are natural platform for including polarization and charge transfer effects within the context of molecular simulations...
June 15, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28447092/the-co-dehydrogenase-accessory-protein-coot-is-a-novel-nickel-binding-protein
#6
J Timm, C Brochier-Armanet, J Perard, B Zambelli, S Ollagnier-de-Choudens, S Ciurli, C Cavazza
In Rhodospirillum rubrum, maturation of Carbon Monoxide Dehydrogenase (CODH) requires three accessory proteins, CooC, CooT and CooJ, dedicated to nickel insertion into the active site, which is constituted by a distorted [NiFe3S4] cubane coordinated with a mononuclear Fe site. CooC is an ATPase proposed to provide the energy required for the maturation process, while CooJ is described as a metallochaperone with 16 histidines and 2 cysteines at the C-terminus, likely involved in metal binding and/or storage...
April 27, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28447091/one-pot-synthesis-and-properties-of-well-defined-butadiynylene-bodipy-oligomers
#7
Wenxing Zhang, Wanle Sheng, Changjiang Yu, Yun Wei, Hua Wang, Erhong Hao, Lijuan Jiao
A homogeneous series of well-defined butadiynylene-BODIPY oligomers containing up to four BODIPY moieties have been synthesized from a "one-pot" oxidative homocoupling reaction of 2,6-di((trimethylsilyl)ethynyl)BODIPY. Further derivation of the resultant BODIPY dimer generates a water-soluble, red-emitting butadiyne-linked BODIPY dimer with pyridinium ions, which can ratiometrically detect viscosity, based on the two fluorescent conformers with the two BODIPY cores twisted and planar to each other depending on the viscosity of the environment...
April 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28446754/phonon-mediated-repulsion-sharp-transitions-and-quasi-self-trapping-in-the-extended-peierls-hubbard-model
#8
J Sous, M Chakraborty, C P J Adolphs, R V Krems, M Berciu
We study two identical fermions, or two hard-core bosons, in an infinite chain and coupled to phonons by interactions that modulate their hopping as described by the Peierls/Su-Schrieffer-Heeger (SSH) model. We show that exchange of phonons generates effective nearest-neighbor repulsion between particles and also gives rise to interactions that move the pair as a whole. The two-polaron phase diagram exhibits two sharp transitions, leading to light dimers at strong coupling and the flattening of the dimer dispersion at some critical values of the parameters...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446034/free-radicals-impair-the-anti-oxidative-stress-activity-of-dj-1-through-the-formation-of-sds-resistant-dimer
#9
Tatsuki Yasuda, Takeshi Niki, Hiroyoshi Ariga, Sanae M M Iguchi-Ariga
DJ-1 is a causative gene for familial Parkinson's disease (PD). Loss-of-function of DJ-1 protein is suggested to contribute to the onset of PD, but the causes of DJ-1 dysfunction remain insufficiently elucidated. In this study, we found that the SDS-resistant irreversible dimer of DJ-1 protein was formed in human dopaminergic neuroblastoma SH-SY5Y cells, when the cells were exposed to massive superoxide inducers such as paraquat and diquat. The dimer was also formed in vitro by superoxide in PQ redox cycling system and hydroxyl radical produced in Fenton reaction...
April 26, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28445972/the-prognostic-value-of-d-dimer-levels-in-endometrial-cancer-patients-treated-with-intensity-modulated-radiation-therapy
#10
Xiaojing Yang, Hanru Ren, Yi Sun, Lihua Zhang, Xinmiao Yang, Hongling Li, Yuhui Shao, Jie Fu
Explain the important role of plasma D-dimer in cancers. Plasma D-dimer is increased in various tumors. However, the predictive value of plasma D-dimer is unclear. This study is aimed to evaluate the prognostic value of the D-dimer level in patients managed with intensity-modulated radiation for endometrial cancer. The D-dimer levels of forty patients with endometrial cancer were assessed before (D1) and after (D2) intensity-modulated radiation therapy (IMRT), respectively. The D-dimer level changes (ΔD) were defined as D2 minus D1...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445832/study-of-the-mechanism-of-protonated-histidine-induced-conformational-changes-in-the-zika-virus-dimeric-envelope-protein-using-accelerated-molecular-dynamic-simulations
#11
Jixue Sun, Yang Li, Pi Liu, Jianping Lin
The Zika virus has drawn worldwide attention because of the epidemic diseases it causes. It is a flavivirus that has an icosahedral protein shell constituted by an envelope glycoprotein (E-protein) and membrane protein (M-protein) in the mature virion. The multistep process of membrane fusion to infect the host cell is pH-induced. To understand the mechanism of the conformational changes in the (E-M)2 protein homodimer embedded in the membrane, two 200-ns accelerated dynamic simulations were performed under different pH conditions...
April 13, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28445705/mutation-characterization-and-heterodimer-analysis-of-patients-with-leukocyte-adhesion-deficiency-including-one-novel-mutation
#12
Shahram Teimourian, Martin De Boer, Dirk Roos, Anna Isaian, Ehsan Moghanloo, Sharhzad Lashkary, Bita Hassani, Hasan Mollanoori, Vahid Babaei, Asaad Azarnezhad
BACKGROUND AND AIM: Leukocyte adhesion deficiency type 1 (LAD-I) is a rare, autosomal recessive disorder of neutrophil migration, characterized by severe, recurrent bacterial infections, inadequate pus formation and impaired wound healing. The ITGB2 gene encodes the β2 integrin subunit (CD18) of the leukocyte adhesion cell molecules, and mutations in this gene cause LAD-I. The aim of the current study was to investigate the mutations in patients diagnosed with LAD-I and functional studies of the impact of two previously reported and a novel mutation on the expression of the CD18/CD11a heterodimer...
April 23, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28445416/structure-function-model-for-kissing-loop-interactions-that-initiate-dimerization-of-ty1-rna
#13
Eric R Gamache, Jung H Doh, Justin Ritz, Alain Laederach, Stanislav Bellaousov, David H Mathews, M Joan Curcio
The genomic RNA of the retrotransposon Ty1 is packaged as a dimer into virus-like particles. The 5' terminus of Ty1 RNA harbors cis-acting sequences required for translation initiation, packaging and initiation of reverse transcription (TIPIRT). To identify RNA motifs involved in dimerization and packaging, a structural model of the TIPIRT domain in vitro was developed from single-nucleotide resolution RNA structural data. In general agreement with previous models, the first 326 nucleotides of Ty1 RNA form a pseudoknot with a 7-bp stem (S1), a 1-nucleotide interhelical loop and an 8-bp stem (S2) that delineate two long, structured loops...
April 26, 2017: Viruses
https://www.readbyqxmd.com/read/28445056/superior-plasticity-and-tabletability-of-theophylline-monohydrate
#14
Shao-Yu Chang, Changquan Calvin Sun
A theophylline monohydrate (THm) powder, with particle size and shape substantially similar to a theophylline anhydrate powder, was prepared by vapor mediated phase conversion. The elimination of possible contributions by particle size and shape to tableting properties made it possible to unambiguously identify the role of bonding area and bonding strength on powder tableting performance. It was also shown that accurate true density is essential for correct analysis and understanding of tableting behavior of THm...
April 26, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28445044/highly-oxygenated-multifunctional-compounds-in-%C3%AE-pinene-secondary-organic-aerosol
#15
Xuan Zhang, Andrew T Lambe, Mary Alice Upshur, William A Brooks, Ariana Gray Be, Regan J Thomson, Franz M Geiger, Jason Douglas Surratt, Zhenfa Zhang, Avram Gold, Stephan Graf, Michael J Cubison, Michael Groessl, John T Jayne, Douglas R Worsnop, Manjula R Canagaratna
Highly oxygenated multifunctional organic compounds (HOMs) originating from biogenic emissions constitute a widespread source of organic aerosols in the pristine atmosphere. Yet, the molecular forms in which HOMs are present in the condensed phase upon gas-particle partitioning remain unclear. In this study, we show that highly oxygenated molecules that contain multiple peroxide functionalities are readily cationized by the attachment of Na(+) during electrospray ionization operated in the positive ion mode...
April 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28445041/verbeekite-the-long-unknown-crystal-structure-of-monoclinic-pdse2
#16
Elisabeth Selb, Martina Tribus, Gunter Heymann
Verbeekite, a monoclinic polymorph of PdSe2, was reported for the first time in 2002 by Roberts et al. The mineral has been discovered in the Musonoi Cu-Co-Mn-U mine, Democratic Republic of Congo, and was named after Dr. Théodore Verbeek, the first geoscientist who studied the palladium mineralization there (1955-1967). Until today, the crystal structure of this very rare mineral has been unknown. By syntheses via multianvil high-pressure/high-temperature methods at 11.5 GPa and 1300 °C, synthetic verbeekite could be obtained in a high degree of purity and comparatively good crystal quality, which made it possible to determine the full crystal structure for PdSe2 verbeekite from single-crystal X-ray diffractometer data: I2/a, a = 671...
April 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28444908/micelles-of-the-chiral-biocompatible-surfactant-1r-2s-dodecyl-2-hydroxy-1-methyl-2-phenylethyl-dimethylammonium-bromide-dmeb-molecular-dynamics-and-fragmentation-patterns-in-gas-phase
#17
David Bongiorno, Serena Indelicato, Leopoldo Ceraulo, Ugo Perricone, Valentina Calabrese, Anna Maria Almerico, Vincenzo Turco Liveri, Marco Tutone
RATIONALE: The study of self-assembly process of surfactant molecules in gas phase is of actually interest for several theoretical and technological reasons related to their possible exploitation as drug carriers, protein shields and cleaning agents in gas phase. METHODS: Stability and fragmentation patterns of singly and multiply charged (either positively or negatively) aggregates of the surfactant (1R,2S)-dodecyl(2-hydroxy-1-methyl-2-phenylethyl) dimethyl ammonium bromide (DMEB) in gas phase have been studied by ion mobility mass spectrometry and tandem mass spectrometry...
April 26, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28444903/electrospray-ionization-mass-spectrometry-for-the-hydrolysis-complexes-of-cisplatin-implications-for-the-hydrolysis-process-of-platinum-complexes
#18
Feifan Xie, Pieter Colin, Jan Van Bocxlaer
Non-enzyme dependent hydrolysis of the drug cisplatin is important for its mode of action and toxicity. However, up until today, the hydrolysis process of cisplatin is still not completely understood. In the present study, the hydrolysis of cisplatin in an aqueous solution was systematically investigated using electrospray ionization mass spectrometry coupled to liquid chromatography. A variety of previously unreported hydrolysis complexes corresponding to mono-, di-, and trimeric species were detected and identified...
April 26, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28443926/defect-induced-ferromagnetism-in-mgo-and-its-exceptional-enhancement-upon-thermal-annealing-a-case-of-transformation-of-various-defect-states
#19
Nimai Pathak, Santosh Kumar Gupta, C L Prajapat, S K Sharma, P S Ghosh, Buddhadev Kanrar, P K Pujari, R M Kadam
MgO particles of few micron size are synthesized through a sol-gel method at different annealing temperatures such as 600 °C (MgO-600), 800 °C (MgO-800) and 1000 °C (MgO-1000). EDX and ICP-AES studies confirmed a near total purity of the sample with respect to paramagnetic metal ion impurities. Magnetic measurements showed a low temperature weak ferromagnetic ordering with a TC (Curie temperature) around 65 K (±5 K). Unexpectedly, the saturation magnetization (Ms) was found to be increased with increasing annealing temperature during synthesis...
April 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28443879/pyrazolates-advance-cerium-chemistry-a-ce-iii-ce-iv-redox-equilibrium-with-benzoquinone
#20
Daniel Werner, Glen B Deacon, Peter C Junk, Reiner Anwander
Two stable cerium(iv) 3,5-dialkylpyrazolate complexes are presented, namely dimeric [Ce(Me2pz)4]2 (Me2pz = 3,5-dimethylpyrazolate) and monomeric Ce(tBu2pz)4 (tBu2pz = 3,5-di-tert-butylpyrazolate) along with their trivalent counterparts [Ce(Me2pz)3] and [Ce(tBu2pz)3]2. All complexes were obtained from protonolysis reactions employing the silylamide precursors Ce[N(SiHMe2)2]4 and Ce[N(SiMe3)2]3. Treatment of homoleptic Ce(IV) and Ce(III) Me2pz complexes with 1,4-hydroquinone (H2hq) or 1,4-benzoquinone (bq), respectively, ultimately gave the same trimetallic Ce(III) species via a cerium redox equilibrium...
April 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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