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https://www.readbyqxmd.com/read/29786607/pre-set-extrusion-bioprinting-for-multiscale-heterogeneous-tissue-structure-fabrication
#1
Donggu Kang, Geunseon Ahn, Donghwan Kim, Hyun-Wook Kang, Seokhwan Yun, Won-Soo Yun, Jin-Hyung Shim, Songwan Jin
Recent advances in three-dimensional (3D) bioprinting technology have led to various attempts in fabricating human tissue-like structures. However, current bioprinting technologies have limitations for creating native tissue-like structures. To resolve these issues, we developed a new pre-set extrusion bioprinting technique that can create heterogeneous, multicellular, and multimaterial structures simultaneously. The key to this ability lies in the use of a precursor cartridge that can stably preserve a multimaterial with a pre-defined configuration that can be simply embedded in a syringe-based printer head...
May 22, 2018: Biofabrication
https://www.readbyqxmd.com/read/29786593/reproductive-function-the-protection-of-the-rights-of-the-people-which-are-sent-to-the-area-of-the-fighting
#2
Vitalii Pashkov, Nataliya Gutorova, Petro Noha
OBJECTIVE: Introduction: The issues of problems of the legal regulation of posthumous reproduction in Ukraine and foreign countries are analysis in the article. The author substantiates the necessity in the creation and acceptance of the State Program of the retrieval of reproductive cells in people who are sending to the area of the fighting. The aim:the purpose of our work is a comprehensive study of post-mortem (post-mortem) reproduction and substantiation of the possibility and necessity of adopting a state program for the selection of reproductive cells of individuals who are sent to a combat zone to ensure their full social protection and assistance in the realization of the right to fatherhood or motherhood...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29784946/interpretable-dimensionality-reduction-of-single-cell-transcriptome-data-with-deep-generative-models
#3
Jiarui Ding, Anne Condon, Sohrab P Shah
Single-cell RNA-sequencing has great potential to discover cell types, identify cell states, trace development lineages, and reconstruct the spatial organization of cells. However, dimension reduction to interpret structure in single-cell sequencing data remains a challenge. Existing algorithms are either not able to uncover the clustering structures in the data or lose global information such as groups of clusters that are close to each other. We present a robust statistical model, scvis, to capture and visualize the low-dimensional structures in single-cell gene expression data...
May 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29779927/patent-ductus-arteriosus-the-physiology-of-transition
#4
REVIEW
Poorva Deshpande, Michelle Baczynski, Patrick J McNamara, Amish Jain
The transition from intrauterine to extrauterine life represents a critical phase of physiological adaptation which impacts many organ systems, most notably the heart and the lungs. The majority of term neonates complete this transition without complications; however, dysregulation of normal postnatal adaptation may lead to acute cardiopulmonary instability, necessitating advanced intensive care support. Although not as well appreciated as changes in vascular resistances, the shunt across the DA plays a crucial physiologic role in the adaptive processes related to normal transitional circulation...
May 5, 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29779873/short-term-intermittent-fasting-induces-long-lasting-gut-health-and-tor-independent-lifespan-extension
#5
James H Catterson, Mobina Khericha, Miranda C Dyson, Alec J Vincent, Rebecca Callard, Steven M Haveron, Arjunan Rajasingam, Mumtaz Ahmad, Linda Partridge
Intermittent fasting (IF) can improve function and health during aging in laboratory model organisms, but the mechanisms at work await elucidation. We subjected fruit flies (Drosophila melanogaster) to varying degrees of IF and found that just one month of a 2-day fed:5-day fasted IF regime at the beginning of adulthood was sufficient to extend lifespan. This long-lasting, beneficial effect of early IF was not due to reduced fecundity. Starvation resistance and resistance to oxidative and xenobiotic stress were increased after IF...
May 8, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29777524/mercury-involvement-in-neuronal-damage-and-in-neurodegenerative-diseases
#6
REVIEW
Veronica Lanza Cariccio, Annalisa Samà, Placido Bramanti, Emanuela Mazzon
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis are characterized by a chronic and selective process of neuronal cell death. Although the causes of neurodegenerative diseases remain still unknown, it is now a well-established idea that more factors, such as genetic, endogenous, and environmental, are involved. Among environmental causes, the accumulation of mercury, a heavy metal considered a toxic agent, was largely studied as a probable factor involved in neurodegenerative disease course...
May 18, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29776812/preservation-with-%C3%AE-1-antitrypsin-improves-primary-graft-function-of-murine-lung-transplants
#7
Jessica Götzfried, Natalia F Smirnova, Carmela Morrone, Brice Korkmaz, Ali Önder Yildirim, Oliver Eickelberg, Dieter E Jenne
BACKGROUND: Vascular damage and primary graft dysfunction increase with prolonged preservation times of transplanted donor lungs. Hence, storage and conservation of donated lungs in protein-free, dextran-containing electrolyte solutions, like Perfadex, is limited to about 6 hours. We hypothesized that transplanted lungs are protected against neutrophil-mediated proteolytic damage by adding α1 -anti-trypsin (AAT), a highly abundant human plasma proteinase inhibitor, to Perfadex. METHODS: A realistic clinically oriented murine model of lung transplantation was used to simulate the ischemia-reperfusion process...
March 30, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29776725/collaterals-management-during-pancreatoduodenectomy-in-patients-with-celiac-axis-stenosis-a-systematic-review-of-the-literature
#8
REVIEW
Francesco Giovanardi, Quirino Lai, Manuela Garofalo, Gabriela A Arroyo Murillo, Eleonore Choppin de Janvry, Redan Hassan, Zoe Larghi Laureiro, Adriano Consolo, Fabio Melandro, Pasquale B Berloco
BACKGROUND/OBJECTIVES: Celiac axis stenosis (CAS) represents an uncommon and typically innocuous condition. However, when a pancreatic resection is required, a high risk for upper abdominal organs ischemia is observed. In presence of collaterals, such a risk is minimized if their preservation is realized. The aim of the present study is to systematically review the literature with the intent to address the routine management of collateral arteries in the case of CAS patients requiring pancreatoduodenectomy...
May 15, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29776005/flexible-and-hierarchical-metal-organic-framework-composites-for-high-performance-catalysis
#9
Ning Huang, Hannah Drake, Jialuo Li, Jiangdong Pang, Ying Wang, Shuai Yuan, Qi Wang, Peiyu Cai, Junsheng Qin, Hong-Cai Zhou
The development of new types of porous composite materials is of great significance owing to their potentially improved performance over those of individual components and extensive applications in separation, energy storage, and heterogeneous catalysis. In this work, we integrated mesoporous metal-organic frameworks (MOFs) with macroporous melamine foam (MF) using a one-pot process, generating a series of MOF/MF composite materials with preserved crystallinity, hierarchical porosity, and increased stability over that of melamine foam...
May 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29774907/plasmon-response-evaluation-based-on-image-derived-arbitrary-nanostructures
#10
S Trautmann, M Richard-Lacroix, A Dathe, H Schneidewind, J Dellith, W Fritzsche, V Deckert
The optical response of realistic 3D plasmonic substrates composed of randomly shaped particles of different size and interparticle distance distributions in addition to nanometer scale surface roughness is intrinsically challenging to simulate due to computational limitations. Here, we present a Finite Element Method (FEM)-based methodology that bridges in-depth theoretical investigations and experimental optical response of plasmonic substrates composed of such silver nanoparticles. Parametrized scanning electron microscopy (SEM) images of surface enhanced Raman spectroscopy (SERS) active substrate and tip-enhanced Raman spectroscopy (TERS) probes are used to simulate the far-and near-field optical response...
May 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29774176/pushing-the-limits-machine-preservation-of-the-liver-as-a-tool-to-recondition-high-risk-grafts
#11
REVIEW
Yuri L Boteon, Simon C Afford, Hynek Mergental
Purpose of the Review: Machine perfusion (MP) is a novel technology recently introduced in liver transplantation, redefining the current practice of organ preservation and pushing the limits of high-risk liver utilisation. This review highlights the key benefits of machine perfusion over conventional static cold storage (SCS), demonstrated in human liver research and clinical transplants. Recent Findings: The first clinical trials have demonstrated both safety and feasibility of MP...
2018: Current Transplantation Reports
https://www.readbyqxmd.com/read/29773003/antioxidant-action-of-an-aqueous-extract-of-royal-sun-medicinal-mushroom-agaricus-brasiliensis-agaricomycetes-in-rats-with-adjuvant-induced-arthritis
#12
Aline Cristine da Silva de Souza, Geferson de Almeida Gonсalves, Andréia Assunсão Soares, Anacharis B de Sá-Nakanishi, Ana Paula de Santi-Rampazzo, Maria Raquel Marсal Natali, Rosane Marina Peralta, Adelar Bracht
The purpose of this study was to evaluate possible effects of the administration of an aqueous Agaricus brasiliensis extract on the oxidative state of the liver, brain, and plasma in adjuvant-induced arthritic rats, a model for human rheumatoid arthritis. Daily doses of 400 mg · kg-1 were administered by gavage for 23 days. This treatment produced significant diminutions in protein carbonylation and lipid damage in the liver, brain, and plasma. It also diminished the tissue reactive oxygen species and increased the antioxidant capacity of the plasma...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29770885/does-near-infrared-nir-fluorescence-angiography-modify-operative-strategy-during-emergency-procedures
#13
Emilie Liot, Michela Assalino, Nicolas Christian Buchs, Boris Schiltz, Jonathan Douissard, Philippe Morel, Frédéric Ris
INTRODUCTION: Bowel viability can be difficult to evaluate during emergency surgery. Near-infrared (NIR) fluorescence angiography allows an intraoperative assessment of organ perfusion during elective surgery and might help to evaluate intestinal perfusion during emergency procedures. The aim of this study was to assess if NIR modified operative strategy during emergency surgery. MATERIALS AND METHODS: From July 2014 to December 2015, we prospectively evaluated all consecutive patients, who had NIR assessment during emergency surgery...
May 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29769543/the-cytokine-secretion-profile-of-mesenchymal-stromal-cells-is-determined-by-surface-structure-of-the-microenvironment
#14
Daniëlle G Leuning, Nick R M Beijer, Nadia A du Fossé, Steven Vermeulen, Ellen Lievers, Cees van Kooten, Ton J Rabelink, Jan de Boer
Mesenchymal stromal cells (MSC) secrete factors that contribute to organ homeostasis and repair in a tissue specific manner. For instance, kidney perivascular mesenchymal stromal cells (kPSCs) can facilitate renal epithelial repair through secretion of hepatocyte growth factor (HGF) while the secretome of bone marrow MSCs gives rise to immunosuppression. Stromal cells function in a complex 3-dimensional (3D) connective tissue architecture that induces conformational adaptation. Here we tested the hypothesis that surface topography and associated cell adaptations dictate stromal cell function through tuning of the cytokines released...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769055/one-visceral-artery-may-be-enough-successful-pancreatectomy-in-a-patient-with-total-occlusion-of-the-celiac-and-superior-mesenteric-arteries
#15
Evangelos Tagkalos, Florian Jungmann, Hauke Lang, Stefan Heinrich
BACKGROUND: The anatomic variations of the visceral arteries are not uncommon. The liver arterial blood supply shows 50% variability between humans, with the most common anatomy being one hepatic artery arising from the celiac trunk and one pancreatico-duodenal arcade between the celiac trunk and the superior mesenteric artery. Occlusion of one artery are mostly asymptomatic but may become clinically relevant when surgery of the liver, bile duct or the pancreas is required. If these pathologies are not reversible, an oncologic pancreatic head resection cannot be performed...
May 16, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29768867/ag-deposited-electrospun-srtio%C3%A2-nanofiber-with-enhanced-photocatalytic-activity-for-degradation-of-methylene-orange
#16
Chechia Hu, Hui-Xin Huang, Yi-Feng Lin
Perovskite SrTiO3 nanofibers were successfully fabricated using a facile electrospinning method followed by calcination in air. The structures, morphologies, and photocatalytic performance of the one-dimensional SrTiO3 nanofibers were determined through X-ray diffraction, UV-visible spectroscopy, scanning electron microscopy, and degradation of organic dye under light irradiation. The nanofibrous SrTiO3 exhibited enhanced photocatalytic activity after photodeposition of Ag on its surface to degrade methylene orange dye...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29768730/biofilm-in-voice-prosthesis-a-prospective-cohort-study-and-laboratory-tests-using-sonication-and-sem-analysis
#17
Jacopo Galli, Lea Calo', Duino Meucci, Monica Giuliani, Daniela Lucidi, Gaetano Paludetti, Riccardo Torelli, Maurizio Sanguinetti, Claudio Parrilla
OBJECTIVE: The objective of the study was to compare the biofilm growing pattern and its morphological extent on silicone and a teflon-like material using a sonication process and a Scanning Electron Microscope (SEM). DESIGN: A prospective cohort study and a laboratory study. SETTING: Otolaryngology -Head and Neck surgery Department and the Microbiology Institute. PARTICIPANTS: The participants included fifteen laryngectomized patients with phonatory prostheses, which were removed due to device failure, and two different kinds of phonatory prostheses from the laboratory (Provox 2 and ActiValve) that were artificially colonized by Candida albicans...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29767061/biochemical-and-histopathological-changes-in-sheep-fed-different-detoxified-karanj-pongamia-glabra-seed-cake-as-partial-protein-supplements
#18
Nira M Soren, Anil K Sharma, Vadali R B Sastry
The study investigated the long-term effect of feeding processed solvent extracted karanj ( Pongamia glabra ) cake (SKC) on gross pathology and histopathological changes in some vital organs, and on the activities of serum enzymes in Jalauni lambs. Twenty-four male lambs were divided into 4 groups and allotted randomly to a soybean meal (SBM) based control (CON) and 3 treatment groups receiving concentrate mixtures, containing water washed (WW), 2.5% lime (LM) and 0.4% binder (BN) treated SKC replacing 50% nitrogen of SBM to meet the protein requirements...
June 2017: Animal nutrition
https://www.readbyqxmd.com/read/29765198/management-of-post-lasik-dry-eye-a-multicenter-randomized-comparison-of-a-new-multi-ingredient-artificial-tear-to-carboxymethylcellulose
#19
Avi Wallerstein, W Bruce Jackson, Jeffrey Chambers, Amir M Moezzi, Hugh Lin, Peter A Simmons
Purpose: To compare the efficacy and safety of a preservative-free, multi-ingredient formulation of carboxymethylcellulose 0.5%, hyaluronic acid 0.1%, and organic osmolytes (CMC-HA), to preservative-free carboxymethylcellulose 0.5% (CMC) in the management of postoperative signs and symptoms of dry eye following laser-assisted in situ keratomileusis (LASIK). Methods: This was a double-masked, randomized, parallel-group study conducted in 14 clinical centers in Canada and Australia...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29765065/the-fate-of-lipid-biosignatures-in-a-mars-analogue-sulfur-stream
#20
Jonathan Tan, James M T Lewis, Mark A Sephton
Past life on Mars will have generated organic remains that may be preserved in present day Mars rocks. The most recent period in the history of Mars that retained widespread surface waters was the late Noachian and early Hesperian and thus possessed the potential to sustain the most evolved and widely distributed martian life. Guidance for investigating late Noachian and early Hesperian rocks is provided by studies of analogous acidic and sulfur-rich environments on Earth. Here we report organic responses for an acid stream containing acidophilic organisms whose post-mortem remains are entombed in iron sulphates and iron oxides...
May 15, 2018: Scientific Reports
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