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https://www.readbyqxmd.com/read/28100371/-changes-in-genotype-prevalence-of-human-papillomavirus-over-10-year-follow-up-of-a-cervical-cancer-screening-cohort
#1
L Dong, S Y Hu, Q Zhang, R M Feng, L Zhang, X L Zhao, J F Ma, S D Shi, X Zhang, Q J Pan, W H Zhang, Y L Qiao, F H Zhao
Objective: To evaluate the dynamic variation of genotypes distribution of human papillomavirus (HPV) over 10-year follow-up in a cervical cancer screening cohort. Methods: Based on the Shanxi Province Cervical Cancer Screening Study Ⅰ cohort, we detected HPV genotypes on the well-preserved exfoliated cervical cells from women who were tested HPV positive from year 2005 to year 2014 using reverse linear probe hybridization assay. The changes of prevalence of type-specific HPV over time among the overall population were estimated using linear mixed models...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28100277/stress-echo-2020-the-international-stress-echo-study-in-ischemic-and-non-ischemic-heart-disease
#2
Eugenio Picano, Quirino Ciampi, Rodolfo Citro, Antonello D'Andrea, Maria Chiara Scali, Lauro Cortigiani, Iacopo Olivotto, Fabio Mori, Maurizio Galderisi, Marco Fabio Costantino, Lorenza Pratali, Giovanni Di Salvo, Eduardo Bossone, Francesco Ferrara, Luna Gargani, Fausto Rigo, Nicola Gaibazzi, Giuseppe Limongelli, Giuseppe Pacileo, Maria Grazia Andreassi, Bruno Pinamonti, Laura Massa, Marco A R Torres, Marcelo H Miglioranza, Clarissa Borguezan Daros, José Luis de Castro E Silva Pretto, Branko Beleslin, Ana Djordjevic-Dikic, Albert Varga, Attila Palinkas, Gergely Agoston, Dario Gregori, Paolo Trambaiolo, Sergio Severino, Ayana Arystan, Marco Paterni, Clara Carpeggiani, Paolo Colonna
BACKGROUND: Stress echocardiography (SE) has an established role in evidence-based guidelines, but recently its breadth and variety of applications have extended well beyond coronary artery disease (CAD). We lack a prospective research study of SE applications, in and beyond CAD, also considering a variety of signs in addition to regional wall motion abnormalities. METHODS: In a prospective, multicenter, international, observational study design, > 100 certified high-volume SE labs (initially from Italy, Brazil, Hungary, and Serbia) will be networked with an organized system of clinical, laboratory and imaging data collection at the time of physical or pharmacological SE, with structured follow-up information...
January 18, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28100249/intraoperative-radiation-therapy-iort-in-soft-tissue-sarcoma
#3
REVIEW
Falk Roeder, Robert Krempien
Soft-tissue sarcoma (STS) represent a rare tumor entity, accounting for less than 1% of adult malignancies. The cornerstone of curative intent treatment is surgery with free margins, although the extent of the surgical approach has been subject to change in the last decades. Multimodal approaches usually including radiation therapy have replaced extensive surgical procedures in order to preserve functionality while maintaining adequate local control. However, the possibility to apply adequate radiation doses by external beam radiation therapy (EBRT) can be limited in some situation especially in case of directly adjacent organs at risk with low radiation tolerance...
January 19, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28099076/extension-of-the-avian-host-range-of-collyriclosis-in-europe
#4
Stamatios A Tahas, Anastasia Diakou, Monika Dressel, Samuel Frei, Fábia M Pinto Azevedo, Maria V Mena Casero, Carla Maia, Paula Grest, Felix Grimm, Jiljí Sitko, Ivan Literak
We describe cases of collyriclosis in apodiform and passeriform birds in Portugal, Switzerland, and Germany. We extend the host range of Collyriculm faba to include apodiform birds ( Apus apus , Apus melba , and Apus pallidus ) and the passerine Sitta europaea (Eurasian Nuthatch). Infections varied in severity from an incidental finding to severe debilitation and death. The infection route remains unclear with the apparent absence from Germany, Portugal, and Switzerland of the first intermediate host of C. faba, the aquatic gastropod Bythinella austriaca, implying that other organisms might be involved in the parasite's life cycle...
January 18, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28097910/purification-and-biochemical-characterization-of-a-novel-thermostable-serine-alkaline-protease-from-aeribacillus-pallidus-c10-a-potential-additive-for-detergents
#5
Vildan Yildirim, Mustafa Ozkan Baltaci, Ilknur Ozgencli, Melda Sisecioglu, Ahmet Adiguzel, Gulsah Adiguzel
An extracellular thermostable alkaline serine protease enzyme from Aeribacillus pallidus C10 (GenBank No: KC333049), was purified 4.85 and 17. 32-fold with a yield of 26.9 and 19.56%, respectively, through DE52 anion exchange and Probond affinity chromatography. The molecular mass of the enzyme was determined through sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), with approximately 38.35 kDa. The enzyme exhibited optimum activity at pH 9 and at temperature 60 °C. It was determined that the enzyme had remained stable at the range of pH 7...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28093660/privacy-preserving-integration-of-medical-data-a-practical-multiparty-private-set-intersection
#6
Atsuko Miyaji, Kazuhisa Nakasho, Shohei Nishida
Medical data are often maintained by different organizations. However, detailed analyses sometimes require these datasets to be integrated without violating patient or commercial privacy. Multiparty Private Set Intersection (MPSI), which is an important privacy-preserving protocol, computes an intersection of multiple private datasets. This approach ensures that only designated parties can identify the intersection. In this paper, we propose a practical MPSI that satisfies the following requirements: The size of the datasets maintained by the different parties is independent of the others, and the computational complexity of the dataset held by each party is independent of the number of parties...
March 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28091710/role-of-concurrent-vaginal-hysterectomy-in-the-outcomes-of-mesh-based-vaginal-pelvic-organ-prolapse-surgery
#7
James C Forde, Bilal Chughtai, Jennifer T Anger, Jialin Mao, Art Sedrakyan
INTRODUCTION AND HYPOTHESIS: Hysterectomy is often performed at the time of pelvic organ prolapse (POP) surgery; yet, there is insufficient evidence regarding the specific effect of hysterectomy on outcomes. We sought to determine the outcomes and associated short-term complications of mesh-based POP surgery with and without concurrent hysterectomy. METHODS: We utilized the New York Statewide Planning and Research Cooperation System (SPARCS) database to identify patients under 55 years of age undergoing surgeries for POP with mesh between 2009 and 2014...
January 13, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28090602/probabilistic-tractography-for-topographically-organized-connectomes
#8
Dogu Baran Aydogan, Yonggang Shi
While tractography is widely used in brain imaging research, its quantitative validation is highly difficult. Many fiber systems, however, have well-known topographic organization which can even be quantitatively mapped such as the retinotopy of visual pathway. Motivated by this previously untapped anatomical knowledge, we develop a novel tractography method that preserves both topographic and geometric regularity of fiber systems. For topographic preservation, we propose a novel likelihood function that tests the match between parallel curves and fiber orientation distributions...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28090298/in-situ-expression-of-bcl-2-in-pulmonary-artery-endothelial-cells-associates-with-pulmonary-arterial-hypertension-relative-to-heart-failure-with-preserved-ejection-fraction
#9
Raymond L Benza, Gretchen Williams, Changgong Wu, Kelly J Shields, Amresh Raina, Srinivas Murali, Michael J Passineau
We have previously reported that pulmonary artery endothelial cells (PAECs) can be harvested from the tips of discarded Swan-Ganz catheters after right heart catheterization (RHC). In this study, we tested the hypothesis that the existence of an antiapoptotic phenotype in PAECs obtained during RHC is a distinctive feature of pulmonary arterial hypertension (PAH; World Health Organization group 1) and might be used to differentiate PAH from other etiologies of pulmonary hypertension. Specifically, we developed a flow cytometry-based measure of Bcl-2 activity, referred to as the normalized endothelial Bcl-2 index (NEBI)...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28087967/periampullary-carcinoma-with-penile-metastasis
#10
W C Pui, N A Nik Azim
Periampullary carcinoma metastases are usually located at regional nodes, adjacent organs, liver or lung. On the other hand, metastatic penile cancer is uncommon. Penile metastasis usually originates from pelvic region with prostate and bladder being the most frequent primary location. We present a very rare case of periampullary carcinoma with penile metastasis in a 49-year-old man. He initially presented with early ampullary type periampullary carcinoma and had pyloric preserving pancreatoduodenectomy and adjuvant chemotherapy...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28079006/a-new-vaccine-delivery-vehicle-and-adjuvant-candidate-bordetella-pertussis-inactivated-whole-cells-entrapped-in-alginate-microspheres
#11
Naser Mohammadpour Dounighi, Fereshteh Shahcheraghi, Mehdi Razzaghi-Abyaneh, Mojtaba Nofeli, Hossein Zolfagharian
There is no doubt about whole cell pertussis vaccine efficacy, but it is necessary to improve the vaccine quality specially to decreasing its toxicity by obtaining good immunogenicity with low bacteria number content. In this work, under optimum condition inactivated B. pertussis bacteria cells entrapped alginate microparticles were fabricated and in vivo immunogenicity and potency of new microparticle based vaccine evaluated in mice. Microspheres loaded inactive B. pertussis bacterium cells were prepared via an emulsification method and analyzed for morphology, size, polydispersity index, loading efficiency, loading capacity, release profile and in vivo potency...
January 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28077871/hyoliths-are-palaeozoic-lophophorates
#12
Joseph Moysiuk, Martin R Smith, Jean-Bernard Caron
Hyoliths are abundant and globally distributed 'shelly' fossils that appear early in the Cambrian period and can be found throughout the 280 million year span of Palaeozoic strata. The ecological and evolutionary importance of this group has remained unresolved, largely because of their poorly constrained soft anatomy and idiosyncratic scleritome, which comprises an operculum, a conical shell and, in some taxa, a pair of lateral spines (helens). Since their first description over 175 years ago, hyoliths have most often been regarded as incertae sedis, related to molluscs or assigned to their own phylum...
January 19, 2017: Nature
https://www.readbyqxmd.com/read/28077443/single-dose-intracardiac-injection-of-pro-regenerative-micrornas-improves-cardiac-function-after-myocardial-infarction
#13
Pierluigi Lesizza, Giulia Prosdocimo, Valentina Martinelli, Gianfranco Sinagra, Serena Zacchigna, Mauro Giacca
RATIONALE: Recent evidence indicates that a few human microRNAs (miRNAs), in particular hsa-miR-199a-3p and hsa-miR-590-3p, stimulate proliferation of cardiomyocytes and, once expressed in the mouse heart using viral vectors, induce cardiac regeneration after myocardial infarction. Viral vectors, however, are not devoid of safety issues and, more notably, drive expression of the encoded miRNAs for indefinite periods of time, which might not be desirable in light of human therapeutic application...
January 11, 2017: Circulation Research
https://www.readbyqxmd.com/read/28076357/soil-leaf-and-root-ecological-stoichiometry-of-caragana-korshinskii-on-the-loess-plateau-of-china-in-relation-to-plantation-age
#14
Quanchao Zeng, Rattan Lal, Yanan Chen, Shaoshan An
Caragana korshinskii, a leguminous shrub, a common specie, is widely planted to prevent soil erosion on the Loess Plateau. The objective of this study was to determine how the plantation ages affected soil, leaf and root nutrients and ecological stoichiometry. The chronosequence ages of C. korshinskii plantations selected for this study were 10, 20 and 30 years. Soil organic carbon (SOC) and soil total nitrogen (STN) of C. korshinskii plantations significantly increased with increase in the chronosequence age...
2017: PloS One
https://www.readbyqxmd.com/read/28074702/operative-technique-and-pitfalls-in-donor-heart-procurement
#15
Yasuhiro Shudo, William Hiesinger, Philip E Oyer, Y Joseph Woo
We describe a simple and reproducible donor heart procurement technique in sequential steps. A detailed understanding of procurement and organ preservation techniques should be an essential part of a heart transplant training program.
January 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28074214/-buschke-lowenstein-tumors
#16
REVIEW
M Sporkert, A Rübben
BACKGROUND: A giant condyloma acuminatum which shows destructive growth but lacking invasion is designated as a Buschke-Lowenstein tumor (BLT). OBJECTIVES: Classification of the BLT and therapeutic guidelines are provided. MATERIALS AND METHODS: A MEDLINE literature search from 2006-2016 was performed. RESULTS: Induction through low-risk mucosotropic human papillomavirus (HPV) infection separates BLT from verrucous carcinoma...
January 10, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28073207/intraoperative-ultrasound-guided-enucleation-of-testicular-nodule
#17
Riccardo Boschian, Giovanni Liguori, Stefano Bucci, Michele Bertolotto, Carlo Trombetta
OBJECTIVE: We report a case of enucleation of a non-palpable right testicular lesion found incidentally at testicular ultrasonography during investigations in a patient with azoospermia. MATERIALS AND METHODS: In 2011 bilateral hypoechoic nonpalpable testicular lesions (5 mm and 3 mm to the right, 3 mm to the left) were found in a 28 years old patient, during diagnostic investigations for azoospermia. In March 2016, ultrasonography showed that the diameter of the right major nodule had grown to 12 mm, characterized by increased vascularization and increased texture...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28070286/influence-of-hydrological-pathways-on-dissolved-organic-carbon-fluxes-in-tropical-streams
#18
Eline Nayara Dantas da Costa, Jéssica Carneiro de Souza, Marilane Andrade Pereira, Marcelo Friederichs Landim de Souza, Weber Friederichs Landim de Souza, Daniela Mariano Lopes da Silva
Water flow pathways and water balance are fundamental components for understanding the dynamics of C in the soil/water interface of small basins. The objective of this study was to describe the seasonal variations and estimate the annual balance of dissolved organic carbon (DOC) by comparing two tropical microbasins (preserved forest-PF and cacao plantation-CP). Twenty-one weekly collections were conducted from September to December 2012 and from April to June 2013. The calculation of the partial balance considered precipitation (P) as inflow and the stream as outflow...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28069953/c-type-lectin-receptor-dcir-modulates-immunity-to-tuberculosis-by-sustaining-type-i-interferon-signaling-in-dendritic-cells
#19
Anthony Troegeler, Ingrid Mercier, Céline Cougoule, Danilo Pietretti, André Colom, Carine Duval, Thien-Phong Vu Manh, Florence Capilla, Renaud Poincloux, Karine Pingris, Jérôme Nigou, Jörg Rademann, Marc Dalod, Frank A W Verreck, Talal Al Saati, Geanncarlo Lugo-Villarino, Bernd Lepenies, Denis Hudrisier, Olivier Neyrolles
Immune response against pathogens is a tightly regulated process that must ensure microbial control while preserving integrity of the infected organs. Tuberculosis (TB) is a paramount example of a chronic infection in which antimicrobial immunity is protective in the vast majority of infected individuals but can become detrimental if not finely tuned. Here, we report that C-type lectin dendritic cell (DC) immunoreceptor (DCIR), a key component in DC homeostasis, is required to modulate lung inflammation and bacterial burden in TB...
January 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28068361/the-use-of-mixed-effects-models-for-obtaining-low-cost-ecosystem-carbon-stock-estimates-in-mangroves-of-the-asia-pacific
#20
Jacob J Bukoski, Jeremy S Broadhead, Daniel C Donato, Daniel Murdiyarso, Timothy G Gregoire
Mangroves provide extensive ecosystem services that support local livelihoods and international environmental goals, including coastal protection, biodiversity conservation and the sequestration of carbon (C). While voluntary C market projects seeking to preserve and enhance forest C stocks offer a potential means of generating finance for mangrove conservation, their implementation faces barriers due to the high costs of quantifying C stocks through field inventories. To streamline C quantification in mangrove conservation projects, we develop predictive models for (i) biomass-based C stocks, and (ii) soil-based C stocks for the mangroves of the Asia-Pacific...
2017: PloS One
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