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https://www.readbyqxmd.com/read/28346828/chemical-transformation-of-colloidal-nanostructures-with-morphological-preservation-by-surface-protection-with-capping-ligands
#1
Wenjing Xu, Mingsheng Wang, Zhiwei Li, Xiaojing Wang, Yongqiang Wang, Mingyang Xing, Yadong Yin
When nanocrystals are made to undergo chemical transformations, there are often accompanying large mechanical deformations and changes to overall particle morphology. These effects can constrain development of multi-step synthetic methods through loss of well-defined particle morphology and functionality. Here, we demonstrate a surface protection strategy for solution phase chemical conversion of colloidal nanostructures that allows for preservation of overall particle morphology despite large volume changes...
March 27, 2017: Nano Letters
https://www.readbyqxmd.com/read/28341773/pml-protein-organizes-heterochromatin-domains-where-it-regulates-histone-h3-3-deposition-by-atrx-daxx
#2
Erwan Delbarre, Kristina Ivanauskiene, Jane Spirkoski, Akshay Shah, Kristin Vekterud, Jan Øivind Moskaug, Stig Ove Bøe, Lee Wong, Thomas Küntziger, Philippe Collas
Maintenance of chromatin homeostasis involves proper delivery of histone variants to the genome. The interplay between different chaperones regulating the supply of histone variants to distinct chromatin domains is largely undeciphered. We report here a role of promyelocytic leukemia (PML) protein in routing histone variant H3.3 to chromatin and in the organization of megabase-size heterochromatic PML-associated domains which we call PADs. Loss of PML alters the heterochromatic state of PADs by shifting the histone H3 methylation balance from K9me3 to K27me3...
March 24, 2017: Genome Research
https://www.readbyqxmd.com/read/28341754/proportional-recovery-from-lower-limb-motor-impairment-after-stroke
#3
Marie-Claire Smith, Winston D Byblow, P Alan Barber, Cathy M Stinear
BACKGROUND AND PURPOSE: In people with preserved corticospinal tract (CST) function after stroke, upper limb impairment resolves by ≈70% within 3 months. This is known as the proportional recovery rule. Patients without CST function do not fit this rule and have worse upper limb outcomes. This study investigated resolution of motor impairment in the lower limb (LL). METHODS: Patients with stroke and LL weakness were assessed 3 days and 3 months after stroke with the LL Fugl-Meyer...
March 24, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28341241/high-dose-rate-brachytherapy-as-monotherapy-for-localised-prostate-cancer-review-of-the-current-status
#4
N Tselis, P Hoskin, D Baltas, V Strnad, N Zamboglou, C Rödel, G Chatzikonstantinou
The aim of this article is to review and present the published data on high dose rate (HDR) brachytherapy as monotherapy in the treatment of localised prostate cancer. A search and review of the literature was carried out on PubMed and MedLine using the medical subject headings 'high-dose-rate, brachytherapy, prostate cancer, monotherapy' as search terms. The search yielded more than 100 articles and abstracts published between 2000 and 2016. Only original clinical data on HDR monotherapy reporting oncological outcomes were included...
March 22, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28340534/raman-spectroscopy-enabled-investigation-of-carbon-nanotubes-quality-upon-dispersion-in-aqueous-environments
#5
Yang Wang, Dzhuliya Vasileva, Silviya P Zustiak, Irma Kuljanishvili
Dispersion of high quality carbon nanotubes (CNTs) in aqueous solutions is of central importance for their potential biological and biomedical applications. Although it is now possible to obtain highly dispersed CNT solutions by means of surfactant assisted processing, organic functionalization, and mechanical mixing, a concern remains about preservation of CNTs' quality during these dispersion procedures. In this report, the authors demonstrate that by employing Raman spectroscopy, one can study changes in CNTs' quality post-dispersion...
March 24, 2017: Biointerphases
https://www.readbyqxmd.com/read/28339553/de-and-recellularization-of-the-pig-uterus-a-bioengineering-pilot-study%C3%A2
#6
Hannes Campo, Pedro M Baptista, Nuria López-Pérez, Amparo Faus, Irene Cervelló, Carlos Simón
Absolute uterine factor infertility, or the absence of a functional uterus, has a prevalence of 3%-5% in the general population. Despite the great strides being made in reproductive medicine, patients diagnosed with absolute uterine factor infertility remain untreatable. The only available solution has been gestational surrogacy, but recently the Brannström group presented a viable alternative by reporting the first successful live birth after uterus transplantation. Similar to other transplantations, this approach has inherent limitations such as the paucity of donor organs and the need for long-term immunosuppression...
December 27, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/28338472/robust-cardiac-motion-estimation-using-ultrafast-ultrasound-data-a-low-rank-topology-preserving-approach
#7
Angelica I Aviles, Thomas Widlak, Alicia Casals, Maartje Nillesen, Habib Ammari
Cardiac motion estimation is an important diagnostic tool to detect heart diseases and it has been explored with modalities such as MRI and conventional ultrasound (US) sequences. US cardiac motion estimation still presents challenges because of the complex motion patterns and the presence of noise. In this work, we propose a novel approach to estimate the cardiac motion using ultrafast ultrasound data. -- Our solution is based on a variational formulation characterized by the L2-regularized class. The displacement is represented by a lattice of b-splines and we ensure robustness by applying a maximum likelihood type estimator...
March 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28338095/the-effect-of-microbial-mats-in-the-decay-of-anurans-with-implications-for-understanding-taphonomic-processes-in-the-fossil-record
#8
M Iniesto, I Villalba, A D Buscalioni, M C Guerrero, A I López-Archilla
The pattern and sequence of the decomposition of the Pipidae African dwarf frog (Hymenochirus boettgeri) is tracked in an experiment with microbial mats in order to explore soft tissue preservation over three years. Frog decay in microbial mats is preceded by rapid entombment (25-30 days) and mediated by the formation of a sarcophagus, which is built by a complex microbial community. The frog carcasses maintained a variety of soft tissues for years. Labile organic structures show greater durability within the mat, cells maintain their general shape (bone marrow cells and adipocytes), and muscles and connective tissues (adipose and fibrous tendons) exhibit their original organic structures...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337272/cold-preservation-with-hyperbranched-polyglycerol-based-solution-improves-kidney-functional-recovery-with-less-injury-at-reperfusion-in-rats
#9
Shadan Li, Bin Liu, Qiunong Guan, Irina Chafeeva, Donald E Brooks, Christopher Yc Nguan, Jayachandran N Kizhakkedathu, Caigan Du
Minimizing donor organ injury during cold preservation (including cold perfusion and storage) is the first step to prevent transplant failure. We recently reported the advantages of hyperbranched polyglycerol (HPG) as a novel substitute for hydroxyethyl starch in UW solution for both cold heart preservation and cold kidney perfusion. This study evaluated the functional recovery of the kidney at reperfusion after cold preservation with HPG solution. The impact of HPG solution compared to conventional UW and HTK solutions on tissue weight and cell survival at 4°C was examined using rat kidney tissues and cultured human umbilical vein endothelial cells (HUVECs), respectively...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28337223/emerging-perspectives-in-scaffold-for-tissue-engineering-in-oral-surgery
#10
REVIEW
Gabriele Ceccarelli, Rossella Presta, Laura Benedetti, Maria Gabriella Cusella De Angelis, Saturnino Marco Lupi, Ruggero Rodriguez Y Baena
Bone regeneration is currently one of the most important and challenging tissue engineering approaches in regenerative medicine. Bone regeneration is a promising approach in dentistry and is considered an ideal clinical strategy in treating diseases, injuries, and defects of the maxillofacial region. Advances in tissue engineering have resulted in the development of innovative scaffold designs, complemented by the progress made in cell-based therapies. In vitro bone regeneration can be achieved by the combination of stem cells, scaffolds, and bioactive factors...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28336935/preservation-of-organic-matter-in-marine-sediments-by-inner-sphere-interactions-with-reactive-iron
#11
Andrew Barber, Jay Brandes, Alessandra Leri, Karine Lalonde, Kathryn Balind, Sue Wirick, Jian Wang, Yves Gélinas
Interactions between organic matter and mineral matrices are critical to the preservation of soil and sediment organic matter. In addition to clay minerals, Fe(III) oxides particles have recently been shown to be responsible for the protection and burial of a large fraction of sedimentary organic carbon (OC). Through a combination of synchrotron X-ray techniques and high-resolution images of intact sediment particles, we assessed the mechanism of interaction between OC and iron, as well as the composition of organic matter co-localized with ferric iron...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28336518/bmp-9-interferes-with-liver-regeneration-and-promotes-liver-fibrosis
#12
Katja Breitkopf-Heinlein, Christoph Meyer, Courtney König, Haristi Gaitantzi, Annalisa Addante, Maria Thomas, Eliza Wiercinska, Chen Cai, Qi Li, Fengqi Wan, Claus Hellerbrand, Nektarios A Valous, Maximilian Hahnel, Christian Ehlting, Johannes G Bode, Stephanie Müller-Bohl, Ursula Klingmüller, Jutta Altenöder, Iryna Ilkavets, Marie-José Goumans, Lukas J A C Hawinkels, Se-Jin Lee, Matthias Wieland, Carolin Mogler, Matthias P Ebert, Blanca Herrera, Hellmut Augustin, Aránzazu Sánchez, Steven Dooley, Peter Ten Dijke
OBJECTIVE: Bone morphogenetic protein (BMP)-9, a member of the transforming growth factor-β family of cytokines, is constitutively produced in the liver. Systemic levels act on many organs and tissues including bone and endothelium, but little is known about its hepatic functions in health and disease. DESIGN: Levels of BMP-9 and its receptors were analysed in primary liver cells. Direct effects of BMP-9 on hepatic stellate cells (HSCs) and hepatocytes were studied in vitro, and the role of BMP-9 was examined in acute and chronic liver injury models in mice...
March 23, 2017: Gut
https://www.readbyqxmd.com/read/28335340/recent-advances-in-chiral-nematic-structure-and-iridescent-color-of-cellulose-nanocrystal-films
#13
REVIEW
Derek G Gray
One unique property of cellulose nanocrystals (CNC) is their property of forming suspensions with chiral nematic order. This order can be preserved in films cast from the suspensions, raising the possibility of applications as photonic materials and templates. However, it has proved difficult to generate uniform, well-ordered chiral nematic materials from CNC. Recently, the importance of kinetic arrest due to gel formation in the later stages of evaporation has been recognized as a key step in film formation...
November 14, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334377/lrit3-differentially-affects-connectivity-and-synaptic-transmission-of-cones-to-on-and-off-bipolar-cells
#14
Marion Neuillé, Yan Cao, Romain Caplette, Debbie Guerrero-Given, Connon Thomas, Naomi Kamasawa, José-Alain Sahel, Christian P Hamel, Isabelle Audo, Serge Picaud, Kirill A Martemyanov, Christina Zeitz
Purpose: Mutations in LRIT3 lead to complete congenital stationary night blindness (cCSNB). Using a cCSNB mouse model lacking Lrit3 (nob6), we recently have shown that LRIT3 has a role in the correct localization of TRPM1 (transient receptor potential melastatin 1) to the dendritic tips of ON-bipolar cells (BCs), contacting both rod and cone photoreceptors. Furthermore, postsynaptic clustering of other mGluR6 cascade components is selectively eliminated at the dendritic tips of cone ON-BCs...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28334331/alterations-of-immune-parameters-on-trichoplusia-ni-lepidoptera-noctuidae-larvae-exposed-to-extremely-low-frequency-electromagnetic-fields
#15
Jose A Valadez-Lira, Nahui O Medina-Chavez, Alonso A Orozco-Flores, J Antonio Heredia-Rojas, Abraham O Rodriguez-de la Fuente, Ricardo Gomez-Flores, Juan M Alcocer-Gonzalez, Patricia Tamez-Guerra
Worldwide mobile telephone and microwave use have resulted in an increasing presence of extremely low-frequency electromagnetic field radiations (ELF-EMFs) in ecosystems. ELF-EMFs have been associated with altered physiological processes that can adversely affect exposed organisms. In this study, Trichoplusia ni Hübner larvae were exposed for 24, 48, or 72 h to ELF-EMFs (60 Hz and 2.0 mT) to assess effects on immune response parameters and fertility. Trichoplusia ni life cycle and fertility were not affected by 24-h exposure...
March 6, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28333889/normothermic-ex-situ-liver-preservation-the-new-gold-standard
#16
Richard W Laing, Hynek Mergental, Darius F Mirza
PURPOSE OF REVIEW: Normothermic machine perfusion of the liver (NMP-L) is a novel technology recently introduced into the practice of liver transplantation. This review recapitulates benefits of normothermic perfusion over conventional static cold storage and summarizes recent publications in this area. RECENT FINDINGS: The first clinical trials have demonstrated both safety and feasibility of NMP-L. They have shown that machine perfusion can entirely replace cold storage or be commenced following a period of cold ischaemia...
March 22, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28333030/semen-quality-before-cryopreservation-and-after-thawing-in-543-patients-with-testicular-cancer
#17
Antonio MacKenna, Javier Crosby, Cristián Huidobro, Eduardo Correa, Gonzalo Duque
OBJECTIVE: The main objective of this study was to assess semen characteristics of patients with testicular cancer before cryopreservation and after thawing, to evaluate the consequences of this technique on sperm quality in patients with testicular cancer. METHODS: Five hundred eighty-nine samples from 543 patients with testicular cancer were cryopreserved between 1995 and 2015, one aliquot per patient was used for a thawing test to assess the impact of cryopreservation on sperm motility; semen analysis was performed before cryo preservation and after thawing, the result interpretation was carried out using the 2010 World Health Organization (WHO) Laboratory Manual, and consent forms were signed by the patients for freezing and when sperm was used for reproductive purposes...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28332570/iron-minerals-within-specific-microfossil-morphospecies-of-the-1-88%C3%A2-ga-gunflint-formation
#18
Kevin Lepot, Ahmed Addad, Andrew H Knoll, Jian Wang, David Troadec, Armand Béché, Emmanuelle J Javaux
Problematic microfossils dominate the palaeontological record between the Great Oxidation Event 2.4 billion years ago (Ga) and the last Palaeoproterozoic iron formations, deposited 500-600 million years later. These fossils are often associated with iron-rich sedimentary rocks, but their affinities, metabolism, and, hence, their contributions to Earth surface oxidation and Fe deposition remain unknown. Here we show that specific microfossil populations of the 1.88 Ga Gunflint Iron Formation contain Fe-silicate and Fe-carbonate nanocrystal concentrations in cell interiors...
March 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28331380/classical-conditioning-for-preserving-the-effects-of-short-melatonin-treatment-in-children-with-delayed-sleep-a-pilot-study
#19
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Frans J Oort
Melatonin treatment is effective in treating sleep onset problems in children with delayed melatonin onset, but effects usually disappear when treatment is discontinued. In this pilot study, we investigated whether classical conditioning might help in preserving treatment effects of melatonin in children with sleep onset problems, with and without comorbid attention deficit hyperactivity disorder (ADHD) or autism. After a baseline week, 16 children (mean age: 9.92 years, 31% ADHD/autism) received melatonin treatment for 3 weeks and then gradually discontinued the treatment...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28330599/impact-of-graft-preservation-solutions-for-liver-transplantation-on-early-cytokine-release-and-postoperative-organ-dysfunctions-a-pilot-study
#20
H Brisson, C Arbelot, A Monsel, C Parisot, M Girard, E Savier, C Vezinet, Q Lu, J-C Vaillant, J-L Golmard, G Gorochov, O Langeron, J-J Rouby
INTRODUCTION: During liver transplantation, graft ischemia-reperfusion injury leads to a systemic inflammatory response producing postoperative organ dysfunctions. The aim of this observational and prospective study was to compare the impact of Solution de conservation des organes et tissus (SCOT) 15 and University of Wisconsin (UW) preservation solutions on early cytokine release, postreperfusion syndrome and postoperative organ dysfunctions. METHODS: Thirty-seven liver transplantations were included: 21 in UW Group and 16 in SCOT 15 group...
March 15, 2017: Clinics and Research in Hepatology and Gastroenterology
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