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https://www.readbyqxmd.com/read/28550648/pregnancy-outcome-in-more-than-5000-births-to-women-with-viral-hepatitis-a-population-based-cohort-study-in-sweden
#1
Knut Stokkeland, Jonas Filip Ludvigsson, Rolf Hultcrantz, Anders Ekbom, Jonas Höijer, Matteo Bottai, Olof Stephansson
Previous studies have shown inconsistent results with respect to hepatitis B (HBV), hepatitis C (HCV) and pregnancy outcome. The aim of this study was to investigate pregnancy outcome in women with HBV or HCV. In a nationwide cohort of births between 2001 and 2011 we investigated the risks of adverse pregnancy outcomes in 2990 births to women with HBV and 2056 births to women with HCV using data from Swedish healthcare registries. Births to women without HBV (n = 1090 979), and births without HCV (n = 1091 913) served as population controls...
May 26, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28549336/evaluation-of-a-new-random-access-hbv-dna-molecular-assay-the-veris-hbv-assay
#2
Slim Fourati, Dominique Challine, Jean-Dominique Poveda, Syria Laperche, Sandrine Rallier, Jean-Michel Pawlotsky, Stéphane Chevaliez
BACKGROUND: Detection and quantification of HBV DNA are essential to diagnose chronic HBV infection, monitor the virological response to treatment and the possible selection of resistant viruses in order to tailor therapy. The VERIS/MDx System HBV Assay is a random-access system that quantifies HBV DNA in clinical samples using unique single sample and reagent access during the workflow process without the need to reload other tests and delivers results within 1.2h following sampling...
May 17, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28547581/gender-disparity-in-hepatocellular-carcinoma-hcc-multiple-underlying-mechanisms
#3
REVIEW
Bo Zheng, Yan-Jing Zhu, Hong-Yang Wang, Lei Chen
On the global scale, hepatitis B virus (HBV) infection is the main cause of hepatocellular carcinoma (HCC) especially in regions of Asia where HBV infection is endemic. Epidemiological studies show that the incidence of inflammation-driven HCC in males is three times as high as in females. Recent studies suggest that sex hormones have a crucial role in the pathogenesis and development of HBV-induced HCC. We found that the estrogen/androgen signaling pathway is associated with decreased/increased transcription and replication of HBV genes and can promote the development of HBV infections by up/downregulating HBV RNA transcription and inflammatory cytokines levels, which in turn slow down the progression of HBV-induced HCC...
May 23, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28545829/gut-microbiota-and-hepatitis-b-virus-induced-chronic-liver-disease-implications-for-faecal-microbiota-transplantation-therapy
#4
REVIEW
Y Kang, Y Cai
Hepatitis B is one of the most common infectious diseases globally. It has been estimated that there are 350 million chronic hepatitis B virus (HBV) carriers worldwide. The liver is connected to the small intestine by the bile duct, which carries bile formed in the liver to the intestine. Nearly all of the blood that leaves the stomach and intestines must pass through the liver. Human intestines contain a wide diversity of microbes, collectively termed the 'gut microbiota'. Gut microbiota play a significant role in host metabolic processes and host immune modulation, and influence host development and physiology (organ development)...
April 15, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28545573/peroxisome-proliferators-activated-receptor-ppar-agonists-activate-hepatitis-b-virus-replication-in-vivo
#5
Lingyao Du, Yuanji Ma, Miao Liu, Libo Yan, Hong Tang
BACKGROUND: PPAR agonists are often used in HBV infected patients with metabolic disorders. However, as liver-enriched transcriptional factors, PPARs would activate HBV replication. Risks exsit in such patients. This study aimed to assess the influence of commonly used synthetic PPAR agonists on hepatitis B virus (HBV) transcription, replication and expression through HBV replicative mouse models, providing information for physicians to make necessary monitoring and therapeutic adjustment when HBV infected patients receive PPAR agonists treatment...
May 25, 2017: Virology Journal
https://www.readbyqxmd.com/read/28545019/circulating-soluble-programmed-death-1-levels-may-differentiate-immune-tolerant-phase-from-other-phases-and-hepatocellular-carcinoma-from-other-clinical-diseases-in-chronic-hepatitis-b-virus-infection
#6
Na Li, Zhihua Zhou, Fang Li, Jiao Sang, Qunying Han, Yi Lv, Wenxuan Zhao, Chunyan Li, Zhengwen Liu
Programmed death-1 (PD-1) is involved in the immune dysfunction of hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). This study analyzed the association of circulating soluble PD-1 (sPD-1) levels with the phases and clinical diseases in chronic HBV infection. Serum sPD-1 levels were determined by enzyme linked immunosorbent assay in patients with different phases and liver diseases of chronic HBV infection. The sPD-1 levels in patients with chronic HBV infection were significantly elevated compared with HBV infection resolvers or healthy controls...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28544694/epidemiology-update-for-hcv-and-hbv-in-esrd-in-france-still%C3%A2-a-lot-to-do
#7
Lucia Parlati, Anne Laurain, Stanislas Pol
No abstract text is available yet for this article.
June 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28544232/peripartum-cytokine-flares-in-a-multiethnic-cohort-of-chronic-hepatitis-b-carriers-does-not-correlate-with-hepatitis-b-virus-suppression-or-increased-risk-of-liver-disease
#8
Shivali S Joshi, Daniel Wong, Eliana Castillo, Mark G Swain, Carla S Coffin
PROBLEM: In chronic hepatitis B (CHB) carriers, alanine transaminase (ALT) flares are common in the peripartum period. There are limited data on immunological changes of pregnancy in CHB. We hypothesize that in pregnant CHB carriers, the Th1/Th2 cytokine ratio is altered resulting in changes in biochemical/virological and liver fibrosis markers. STUDY METHODS: Serum from 38 pregnant/post-partum CHB carriers (median age 32 years, 53% Asian, 8 HBeAg(+) ) was tested for HBV DNA, quantitative HBV surface antigen, ALT and liver fibrosis by transient elastography (TE)...
May 19, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28544156/m2bpgi-as-a-potential-diagnostic-tool-of-cirrhosis-in-chinese-patients-with-hepatitis-b-virus-infection
#9
Bin Wei, Shu Feng, Enqiang Chen, Dongdong Li, Tingting Wang, Yu Gou, Tingting Yang, Dongmei Zhang, Chuanmin Tao, Hong Tang
BACKGROUND: M2BPGi is a novel serum glycobiomarker of liver fibrosis. In this study, we aimed to evaluate the efficacy of M2BPGi for predicting liver fibrosis and disease progression in Chinese hepatitis B virus (HBV) infected patients. METHODS: We enrolled 228 HBV infected patients with different status of liver fibrosis diagnosed using FibroScan. We analyzed the diagnostic accuracy of M2BPGi, and compared it with AST-to-platelet ratio (APRI), FIB-4 index, AST to ALT ratio (AAR), and RDW to platelet ratio (RPR)...
May 24, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28544047/comparison-of-oral-fluid-collection-methods-for-the-molecular-detection-of-hepatitis-b-virus
#10
Moyra Machado Portilho, Ana Carolina da Fonseca Mendonça, Vanessa Alves Marques, Leticia Cancella Nabuco, Cristiane Alves Villela-Nogueira, Claudia Ivantes, Lia Laura Lewis-Ximenez, Elisabeth Lampe, Livia Melo VIllar
BACKGROUND: This study aims to compare the efficiency of four oral fluid collection methods (Salivette, FTA Card, spitting and DNA-Sal) to detect HBV DNA by qualitative PCR. MATERIALS AND METHODS: Seventy-four individuals (32 HBV reactive and 42 with no HBV markers) donated serum and oral fluid. In-house qualitative PCR to detect HBV was used for both samples and commercial quantitative PCR for serum. RESULTS: HBV DNA was detected in all serum samples from HBV-infected individuals, and it was not detected in control group...
May 19, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28543911/polymorphism-of-tlr5-rs5744174-is-associated-with-disease-progression-in-chinese-patients-with-chronic-hbv-infection
#11
Lina Cao, Tong Zhang, Junping Zhu, Aixin Li, Kai Zheng, Nan Zhang, Bin Su, Wei Xia, Hao Wu, Ning Li, Qiushui He
Toll-like receptors (TLRs) play a crucial role in innate and adaptive immunity, protecting the host from viral pathogens. Studies have implicated that TLR5 is associated with various diseases such as autoimmune and inflammation related diseases. However, little is known about the relationship between TLR5 and hepatitis B virus (HBV) infection. We studied the effect of TLR5 gene polymorphisms on susceptibility to and disease progression of chronic hepatitis B (CHB) infection in Chinese. Blood samples were taken from 636 patients with CHB, HBV-related liver cirrhosis (LC) or hepatocellular carcinoma (HCC) and 273 controls...
May 25, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28543299/low-occurrence-of-hbsag-but-high-frequency-of-transient-occult-hbv-infection-in-vaccinated-and-hbig-administered-infants-born-to-hbsag-positive-mothers
#12
Shan Zhou, Tingting Li, Jean-Pierre Allain, Bin Zhou, Yuming Zhang, Mei Zhong, Yongshui Fu, Chengyao Li
The status of chronic and occult HBV infection (OBI) in neonatal hepatitis B vaccine and immunoglobulin (HBIG) vaccinated infants born to HBsAg+ mothers was investigated at a major hospital in China. Seventy-seven and 15 blood samples were collected in first or second follow-up detection from the vaccinated babies aged 3 to 36 months born to 43 HBsAg+ or plus 25 HBeAg+ mothers. HBV infection was analyzed between the paired baby and mother by serology and DNA analysis. Among 77 children born to 68 HBsAg+ mothers, 3...
May 23, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28543021/a-30-year-systematic-review-and-meta-analysis-of-hepatitis%C3%A2-b-virus-among-blood-donors-in-mainland-china-revealing-increase-of-new-threats
#13
Zhan Gao, Yu Zhang, Hua Shan, Ling Shi, Jing Liu, Min Xu, Peibin Zeng, Yu Liu, Miao He
BACKGROUND: Although screening strategies have been routinely implemented in blood centers, the residual risk of transfusion-transmitted hepatitis B virus (HBV) still poses a public health concern in China. The aim of this study is to investigate the HBV blood screening reactive rate and to illustrate the demographics of the corresponding blood donors with revealing of heterogeneity between previous studies and discovering potentially negligent threats. STUDY DESIGN AND METHODS: Literature reporting the HBV screening reactive rate in Chinese blood donors was identified by systematic searching of four electronic databases...
May 19, 2017: Transfusion
https://www.readbyqxmd.com/read/28540167/t-cell-associated-immunoregulation-and-antiviral-effect-of-oxymatrine-in-hydrodynamic-injection-hbv-mouse-model
#14
Xiuxiu Sang, Ruilin Wang, Yanzhong Han, Cong'en Zhang, Honghui Shen, Zhirui Yang, Yin Xiong, Huimin Liu, Shijing Liu, Ruisheng Li, Ruichuang Yang, Jiabo Wang, Xuejun Wang, Zhaofang Bai, Xiaohe Xiao
Although oxymatrine (OMT) has been shown to directly inhibit the replication of hepatitis B virus (HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection. The infection was achieved by tail vein injection of a large volume of DNA solution. OMT (2.2, 6.7 and 20 mg/kg) was administered by daily intraperitoneal injection for 6 weeks. The efficacy of OMT was evaluated by the levels of HBV DNA, hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and hepatitis B core antigen (HBcAg)...
May 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28539842/a-review-of-antiviral-use-for-the-treatment-of-chronic-hepatitis-b-virus-infection-in-pregnant-women
#15
Ariel Jaffe, Robert S Brown
Mother-to-child transmission (MTCT) of hepatitis B virus (HBV) remains high even with the proper use of active-passive immunoprophylaxis in newborns. Mothers with significant viremia are at a much higher risk of MTCT; therefore, treatments aimed at lowering HBV DNA levels during pregnancy may ultimately decrease global disease burden. The exact threshold for treatment remains controversial; however, most studies have accepted levels greater than 2 × 5 log10 IU/mL as significant viremia. We reviewed the most recent literature on antiviral efficacy, maternal and fetal safety, and viral resistance patterns when used for short-duration therapy in pregnancy...
March 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28538269/novel-therapies-and-potential-therapeutic-targets-in-the-management-of-chronic-hepatitis-b
#16
Joao M Serigado, Manhal Izzy, Harmit Kalia
Chronic hepatitis B is a persistent and progressive inflammatory liver disease caused by infection with the hepatitis B virus (HBV). More than 240 million individuals are infected with HBV worldwide and hepatitis B accounts for an estimated 650 000 deaths annually. Approximately up to 30% of chronically infected patients will develop complications of HBV infection including, but not limited to, liver cirrhosis, end-stage liver disease, and hepatocellular carcinoma. Currently approved therapies have improved clinical outcomes, but have a considerable side-effect profile, elevated cost, and a finite course of treatment...
May 19, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28538267/cirrhosis-has-no-impact-on-therapeutic-responses-of-entecavir-for-chronic-hepatitis-b
#17
Pin-Chao Wang, Tao-Yang Wei, Tai-Chung Tseng, Hans Hsienhong Lin, Chia-Chi Wang
OBJECTIVE: As the efficacy of a direct antiviral agent is reduced in cirrhotic chronic hepatitis C patients, prolonged duration of treatment or addition of ribavirin is recommended to improve the rates of sustained virological response. However, the impact of cirrhosis on the efficacy of antiviral treatment for chronic hepatitis B (CHB) remained unclear. PATIENTS AND METHODS: This retrospective cohort study screened entecavir (ETV)-treated CHB patients in Taipei Tzu Chi Hospital from January 2007 till October 2014...
May 19, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28537900/wisteria-floribunda-agglutinin-positive-human-mac-2-binding-protein-predicts-liver-cancer-development-in-chronic-hepatitis-b-patients-under-antiviral-treatment
#18
Ka-Shing Cheung, Wai-Kay Seto, Danny Ka-Ho Wong, Lung-Yi Mak, Ching-Lung Lai, Man-Fung Yuen
AIM: The risk factors for hepatocellular carcinoma (HCC) development in chronic hepatitis B (CHB) patients with undetectable serum HBV DNA under nucleos(t)ide analogue (NA) therapy are not well defined. We aimed to examine the relationship between Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA+-M2BP) and HCC development in these patients. RESULTS: There was a significant difference in the median levels of pre-treatment WFA+-M2BP between the HCC and control groups (0...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28537543/molecular-epidemiology-of-hepatitis-b-virus-infection-in-tanzania
#19
Joseph C Forbi, Michael Dillon, Michael A Purdy, Bakary S Drammeh, Alexandra Tejada-Strop, Daniel McGovern, Guo-Liang Xia, Yulin Lin, Lilia M Ganova-Raeva, David S Campo, Hong Thai, Gilberto Vaughan, Dunstan Haule, Regina P Kutaga, Sridhar V Basavaraju, Saleem Kamili, Yury E Khudyakov
Despite the significant public health problems associated with hepatitis B virus (HBV) in sub-Saharan Africa, many countries in this region do not have systematic HBV surveillance or genetic information on HBV circulating locally. Here, we report on the genetic characterization of 772 HBV strains from Tanzania. Phylogenetic analysis of the S-gene sequences showed prevalence of HBV genotype A (HBV/A, n=671, 86.9 %), followed by genotypes D (HBV/D, n=95, 12.3 %) and E (HBV/E, n=6, 0.8 %). All HBV/A sequences were further classified into subtype A1, while the HBV/D sequences were assigned to a new cluster...
May 25, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28535669/acute-hepatitis-a-b-and-c-but-not-d-is-still-prevalent-in-mongolia-a-time-trend-analysis
#20
Oidov Baatarkhuu, Hye Won Lee, Jacob George, Dashchirev Munkh-Orshikh, Baasankhuu Enkhtuvshin, Sosorbaram Ariunaa, Mohammed Eslam, Sang Hoon Ahn, Kwang-Hyub Han, Do Young Kim
Background/Aims: Mongolia has one of the highest hepatitis A, C, B and D infection incidences worldwide. We sought to investigate changes in the proportion of acute viral hepatitis types in Mongolia over the last decade. Methods: The cohort comprised 546 consecutive patients clinically diagnosed with acute viral hepatitis from January 2012 to December 2014 in Ulaanbaatar Hospital, Mongolia. A time trend analysis investigating the change in proportion of acute hepatitis A virus, hepatitis C virus (HCV), hepatitis B virus (HBV) and hepatitis delta virus (HDV) infection among the cohort with respect to a previous published study was undertaken...
May 2, 2017: Clinical and Molecular Hepatology
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