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https://www.readbyqxmd.com/read/28811745/inhibition-of-inflammation-mediated-through-the-tumor-necrosis-factor-%C3%AE-biochemical-pathway-can-lead-to-favorable-outcomes-in-alzheimer-disease
#1
REVIEW
Daniah Shamim, Michael Laskowski
Tumor necrosis factor α (TNF-α) inhibitors have long been used as disease-modifying agents in immune disorders. Recently, research has shown a role of chronic neuroinflammation in the pathophysiology of neurodegenerative diseases such as Alzheimer disease, and interest has been generated in the use of anti-TNF agents and TNF-modulating agents for prevention and treatment. This article extensively reviewed literature on animal studies testing these agents. The results showed a role for direct and indirect TNF-α inhibition through agents such as thalidomide, 3,6-dithiothalidomide, etanercept, infliximab, exendin-4, sodium hydrosulfide, minocycline, imipramine, and atorvastatin...
2017: Journal of Central Nervous System Disease
https://www.readbyqxmd.com/read/28811735/asian-american-dietary-sources-of-sodium-and-salt-behaviors-compared-with-other-racial-ethnic-groups-nhanes-2011-2012
#2
Melanie J Firestone, Jeannette M Beasley, Simona C Kwon, Jiyoung Ahn, Chau Trinh-Shevrin, Stella S Yi
OBJECTIVE: Asian Americans consume more sodium than other racial/ethnic groups. The purpose of this analysis was to describe major sources of sodium intake to inform sodium reduction initiatives. METHODS: Cross-sectional data on adults (aged >18 years) from the National Health and Nutrition Examination Survey (NHANES) 2011-2012 with one 24-hour dietary recall were analyzed (n=5,076). Population proportions were calculated from "What We Eat in America" (WWEIA) food categories...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/28810844/effect-of-tolvaptan-on-renal-handling-of-water-and-sodium-gfr-and-central-hemodynamics-in-autosomal-dominant-polycystic-kidney-disease-during-inhibition-of-the-nitric-oxide-system-a-randomized-placebo-controlled-double-blind-crossover-study
#3
Safa Al Therwani, My Emma Sofie Malmberg, Jeppe Bakkestroem Rosenbaek, Jesper Noergaard Bech, Erling Bjerregaard Pedersen
BACKGROUND: Tolvaptan slows progression of autosomal dominant polycystic kidney disease (ADPKD) by antagonizing the vasopressin-cAMP axis. Nitric oxide (NO) stimulates natriuresis and diuresis, but its role is unknown during tolvaptan treatment in ADPKD. METHODS: Eighteen patients with ADPKD received tolvaptan 60 mg or placebo in a randomized, placebo-controlled, double blind, crossover study. L-NMMA (L-NG-monomethyl-arginine) was given as a bolus followed by continuous infusion during 60 min...
August 15, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28809812/the-healthy-eating-agenda-in-australia-is-salt-a-priority-for-manufacturers
#4
Rebecca Lindberg, Tyler Nichols, Chrystal Yam
Many nation states have endorsed and acted on the World Health Organization's target of a 30% reduction in global salt consumption by 2025. In Australia, new government-led voluntary measures were initiated in 2009, consisting of public-private partnerships, front-of-pack labelling, and food reformulation targets (which include reduced salt). How Australia's private sector has responded to this healthy eating agenda has been investigated in a limited way, particularly with regards to manufacturers which produce processed foods considered significant sources of sodium...
August 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28809558/aliphatic-c-sp3-h-bond-activation-using-nickel-catalysis-mechanistic-insights-on-regioselective-arylation
#5
Sukriti Singh, Surya K, Raghavan B Sunoj
Transition metal catalyzed C(sp3)-H bond activation in aliphatic compounds are of current interest. Lack of mechanistic insights on Ni-catalyzed C(sp3)-H activation using 8-aminoquinoline as a directing group motivated us to examine an interesting direct arylation of an aliphatic tertiary amide by using density functional theory. The catalysis employed Ni(II) pre-catalyst, 4-iodoanisole as an arylating agent, sodium carbonate and mesitylenic acid as additives in DMF solvent. Examination of a comprehensive set of mechanistic pathways helped us learn that the most preferred route begins with a bidentate chelate binding of deprotonated substrate to the Ni...
August 15, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28809417/co9s8-nanoparticles-anchored-on-nitrogen-and-sulfur-dual-doped-carbon-nanosheets-as-highly-efficient-bifunctional-electrocatalyst-for-oxygen-evolution-and-reduction-reactions
#6
Can Wu, Yuhang Zhang, Duo Dong, Haiming Xie, Jinghong Li
To promote the practical application of electrochemical energy storage and conversion systems, nonprecious electrocatalysts of low cost and with highly efficient performance in oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) are highly desired. In this work, a cubic sodium chloride (NaCl) crystal-templated strategy is proposed for coupling Co9S8 nanoparticles to nitrogen- and sulfur-doped carbon nanosheets (Co9S8/N,S-CNS) by facile pyrolysis. The nitrogen and sulfur dual-doped carbon nanosheets can effectively prevent the aggregation of Co9S8 nanoparticles and greatly improve the conductivity of the hybrid structure...
August 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28809117/n5-in-solution-isotopic-labeling-and-further-details-of-its-synthesis-by-phenyl-pentazole-reduction
#7
Boris Bazanov, Uzi Geiger, Dan Grinstein, Shmuel Welner, Yehuda Haas
The cyclopentazolate anion, N5-, has been researched extensively over the years and detected in the gas phase more than a decade ago, but was only recently measured in solution. The process whereby aryl pentazole reduction leads to the production of N5- is still not fully understood. Here, the production of N5- in solution was investigated using isotopic labeling techniques while implementing changes to the synthesis methodologies. 15N labeled phenyl pentazole produced appropriately labeled phenyl pentazole radical anions and N5- which, upon collision induced dissociation, produced the expected N3- signals...
August 15, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28806662/porous-co2p-nanowires-as-high-efficient-bifunctional-catalysts-for-4-nitrophenol-reduction-and-sodium-borohydride-hydrolysis
#8
Xingkai Huang, Dengfeng Wu, Daojian Cheng
The development of highly efficient and non-noble catalysts for both the reduction of 4-nitrophenol (4-NP) and NaBH4 hydrolysis is extraordinary attractive but it remains a tremendous challenge. In this work, self-assembled porous Co2P nanowires (NWs) have been successfully prepared via the low-temperature hydrothermal method and the comprehensive experiments validate that the sample is a high efficient bifunctional catalyst for both the reduction of 4-nitrophenol and sodium borohydride hydrolysis. Specifically, the as-prepared porous Co2P NWs exhibit more excellent catalytic performance (knor=743s(-1)g(-1)) than that of other reported catalysts towards reduction of 4-nitrophenol...
August 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28806224/bromodomain-containing-protein-4-activates-voltage-gated-sodium-channel-1-7-transcription-in-dorsal-root-ganglia-neurons-to-mediate-thermal-hyperalgesia-in-rats
#9
Ming-Chun Hsieh, Yu-Cheng Ho, Cheng-Yuan Lai, Hsueh-Hsiao Wang, An-Sheng Lee, Jen-Kun Cheng, Yat-Pang Chau, Hsien-Yu Peng
BACKGROUND: Bromodomain-containing protein 4 binds acetylated promoter histones and promotes transcription; however, the role of bromodomain-containing protein 4 in inflammatory hyperalgesia remains unclear. METHODS: Male Sprague-Dawley rats received hind paw injections of complete Freund's adjuvant to induce hyperalgesia. The dorsal root ganglia were examined to detect changes in bromodomain-containing protein 4 expression and the activation of genes involved in the expression of voltage-gated sodium channel 1...
August 11, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28805727/leaf-physiological-and-proteomic-analysis-to-elucidate-silicon-induced-adaptive-response-under-salt-stress-in-rosa-hybrida-rock-fire
#10
Prabhakaran Soundararajan, Abinaya Manivannan, Chung Ho Ko, Sowbiya Muneer, Byoung Ryong Jeong
Beneficial effects of silicon (Si) on growth and development have been witnessed in several plants. Nevertheless, studies on roses are merely reported. Therefore, the present investigation was carried out to illustrate the impact of Si on photosynthesis, antioxidant defense and leaf proteome of rose under salinity stress. In vitro-grown, acclimatized Rosa hybrida 'Rock Fire' were hydroponically treated with four treatments, such as control, Si (1.8 mM), NaCl (50 mM), and Si+NaCl. After 15 days, the consequences of salinity stress and the response of Si addition were analyzed...
August 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28805678/sodium-chloride-and-its-influence-on-the-aroma-profile-of-yeasted-bread
#11
Markus C E Belz, Claudia Axel, Jonathan Beauchamp, Emanuele Zannini, Elke K Arendt, Michael Czerny
The impact of sodium chloride (NaCl) concentration on the yeast activity in bread dough and its influence on the aroma profile of the baked bread was investigated. Key aroma compounds in the bread samples were analysed by two-dimensional high-resolution gas chromatography-mass spectrometry in combination with solvent-assisted flavour evaporation distillation. High-sensitivity proton-transfer-reaction mass spectrometry was used to detect and quantify 2-phenylethanol in the headspace of the bread dough during fermentation...
August 12, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28803025/the-effect-of-nano-tio2-photocatalysis-on-the-antioxidant-activities-of-cu-zn-sod-at-physiological-ph
#12
Wen Zheng, Hai-Feng Zou, Shao-Wu Lv, Yan-Hong Lin, Min Wang, Fei Yan, Ye Sheng, Yan-Hua Song, Jie Chen, Ke-Yan Zheng
Security issues of nanoparticles on biological toxicity and potential environmental risk have attracted more and more attention with the rapid development and wide applications of nanotechnology. In this work, we explored the effect and probable mechanism of nano-TiO2 on antioxidant activity of copper, zinc superoxide dismutase (Cu, Zn-SOD) under natural light and mixed light at physiological pH. Nano-TiO2 was prepared by sol-hydrothermal method, and then characterized by X-ray Diffraction (XRD) and Transmission electron micrographs (TEM)...
August 5, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28802284/simple-questions-in-salt-intake-behavior-assessment-comparison-with-urinary-sodium-excretion-in-japanese-adults
#13
Ken Uechi, Keiko Asakura, Yuki Sasaki, Shizuko Masayasu, Satoshi Sasaki
BACKGROUND AND OBJECTIVES: To clarify whether six conventional 'high-risk' behaviors toward excess salt intake captured by simple questions such as frequency of salty food consumption are related to actual salt intake. Also, to examine the relationship of nutrition knowledge, food label use, and food preparation with actual salt intake. METHODS AND STUDY DESIGN: Study participants were 742 subjects (370 men and 372 women) aged 20-69 years from 20 areas of Japan...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28802207/the-effect-of-aluminium-and-sodium-impurities-on-the-in-vitro-toxicity-and-pro-inflammatory-potential-of-cristobalite
#14
C Nattrass, C J Horwell, D E Damby, D Brown, V Stone
BACKGROUND: Exposure to crystalline silica (SiO2), in the form of quartz, tridymite or cristobalite, can cause respiratory diseases, such as silicosis. However, the observed toxicity and pathogenicity of crystalline silica is highly variable. This has been attributed to a number of inherent and external factors, including the presence of impurities. In cristobalite-rich dusts, substitutions of aluminium (Al) for silicon (Si) in the cristobalite structure, and impurities occluding the silica surface, have been hypothesised to decrease its toxicity...
August 9, 2017: Environmental Research
https://www.readbyqxmd.com/read/28801267/primum-non-nocere-the-effects-of-sodium-hypochlorite-on-dentin-as-used-in-endodontics
#15
Li-Sha Gu, Xue-Qing Huang, Brandon Griffin, Brian R Bergeron, David H Pashley, Li-Na Niu, Franklin R Tay
The medical literature is replete with the maxim 'primum non nocere', cautioning health care providers to avoid doing any harm to human subjects in their delivery of medical care. Sodium hypochlorite (NaOCl) is a well-established irrigant for root canal treatment because of its antimicrobial and organic tissue remnant dissolution capability. However, little is known about the deleterious effect of this strong oxidizing agent on the integrity of human mineralized dentin. Iatrogenically-induced loss of dentin integrity may precipitate post-treatment root fracture and has potential medico-legal complications...
August 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28800936/associations-between-dietary-salt-potassium-and-blood-pressure-in%C3%A2-south-african-adults-who-sage-wave-2-salt-tobacco
#16
L J Ware, K Charlton, A E Schutte, M Cockeran, N Naidoo, P Kowal
BACKGROUND & AIMS: In June 2016, South Africa implemented legislation mandating maximum sodium levels in a range of processed foods with a goal of reducing population salt intake and disease burden from hypertension. Our aim was to explore the relationship between salt and blood pressure (BP) in a subsample of the World Health Organization Study on global AGEing and adult health (SAGE) Wave 2 before implementation of legislation in South Africa. METHODS & RESULTS: Blood pressure (BP) was measured in triplicate (n = 2722; median age 56 years; 33% male) and 24-h urine collected in a nested subsample (n = 526) for sodium, potassium and creatinine analysis...
July 8, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28800827/modelling-the-effect-of-water-activity-reduction-by-sodium-chloride-or-glycerol-on-conidial-germination-and-radial-growth-of-filamentous-fungi-encountered-in-dairy-foods
#17
Nicolas Nguyen Van Long, Karim Rigalma, Louis Coroller, Robin Dadure, Stella Debaets, Jérôme Mounier, Valérie Vasseur
Water activity (aw) is one of the most influential abiotic factors affecting fungal development in foods. The effects of aw reduction on conidial germination and radial growth are generally studied by supplementing culture medium with the non-ionic solute glycerol despite food aw can also depend on the concentration of ionic solutes such as sodium chloride (NaCl). The present study aimed at modelling and comparing the effects of aw, either modified using NaCl or glycerol, on radial growth and/or conidial germination parameters for five fungal species occurring in the dairy environment...
December 2017: Food Microbiology
https://www.readbyqxmd.com/read/28800174/curcumin-ameliorates-diclofenac-sodium-induced-nephrotoxicity-in-male-albino-rats
#18
Ahmady Y Ahmed, Amany M Gad, Ola M Abd El-Raouf
Exposure to drugs often results in toxicity in the kidney which represents the major control system maintaining homeostasis of the body and thus is especially susceptible to xenobiotics. Nephrotoxicity is a life-threatening side-effect of nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac is one of the most frequently prescribed NSAIDs and have been reported to cause multiple organs damage. Curcumin (CUR) exhibits nephroprotective properties. Therefore, rats were divided into four groups; rats of groups 3 and 4 received diclofenac (100 mg/kg, i...
August 11, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28799108/an-lc-ms-chemical-derivatization-method-for-the-measurement-of-five-different-one-carbon-states-of-cellular-tetrahydrofolate
#19
Li Chen, Gregory S Ducker, Wenyun Lu, Xin Teng, Joshua D Rabinowitz
The cofactor tetrahydrofolate (THF) is used to reduce, oxidize, and transfer one-carbon (1C) units required for the synthesis of nucleotides, glycine, and methionine. Measurement of intracellular THF species is complicated by their chemical instability, signal dilution caused by variable polyglutamation, and the potential for interconversion among these species. Here, we describe a method using negative mode liquid chromatography-mass spectrometry (LC-MS) to measure intracellular folate species from mammalian cells...
August 10, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28797524/systematic-review-of-metformin-monotherapy-and-dual-therapy-with-sodium-glucose-co-transporter-2-inhibitor-sglt-2-in-treatment-of-type-2-diabetes-mellitus
#20
Nagashekhara Molugulu, Lai Shu Yee, Yew Tze Ye, Tan Chew Khee, Lee Zhen Nie, Neoh Jia Yee, Tian Kar Yee, Tan Chee Liang, Prashant Kesharwani
BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a chronic disorder and its treatment with only metformin often does not provide optimum glycemic control. Addition of sodium glucose cotransporter 2 inhibitor (SGLT2) will improve the glycemic control in patients on metformin alone. In this study, an attempt is made to investigate the combined therapy of SGLT-2 with metformin in managing T2DM in terms of lowering HbA1c and body weight and monotherapy using metformin alone in HbA1c and body weight reduction...
July 25, 2017: Diabetes Research and Clinical Practice
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