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https://www.readbyqxmd.com/read/29793053/aggressive-fluid-and-sodium-restriction-in-decompensated-heart-failure-with-preserved-ejection-fraction-results-from-a-randomized-clinical-trial
#1
Karina Sanches Machado d'Almeida, Eneida Rejane Rabelo-Silva, Gabriela Corrêa Souza, Melina Maria Trojahn, Sofia Louise Santin Barilli, Graziella Aliti, Luís Eduardo Rohde, Andreia Biolo, Luís Beck-da-Silva
OBJECTIVES: Sodium and fluid restriction is commonly prescribed for heart failure patients. However, its role in the treatment of heart failure with preserved ejection fraction (HFpEF) remains unclear. The aim of this study was to compare the effect of a diet with sodium and fluid restriction with an unrestricted diet in patients admitted for decompensated HFpEF. METHODS: Patients were randomized to a diet with sodium (0.8 g/d) and fluid (800 mL/d) restriction (intervention group [IG]) or an unrestricted diet (control group [CG]) and followed for 7 d or hospital discharge...
March 21, 2018: Nutrition
https://www.readbyqxmd.com/read/29792136/zinc-dependent-histone-deacetylase-inhibitors-in-cancer-therapeutics-recent-update
#2
Panagiotis I Georgianos, Maria Divani, Theodoros Eleftheriadis, Peter R Mertens, Vassilios Liakopoulos
BACKGROUND: Despite optimal management of diabetic kidney disease (DKD) with intensive glycemic control and administration of agents blocking the renin-angiotensin-aldosterone-system, the residual risk for nephropathy progression to end-stage-renal-disease (ESRD) remains high. Sodium-glucose co-transporter type 2 (SGLT-2)-inhibitors represent a newly-introduced anti-diabetic drug class with pleiotropic actions extending above their glucose-lowering efficacy. Herein, we provide an overview of preclinical and clinical-trial evidence supporting a protective effect of SGLT-2 inhibitors on DKD...
May 23, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29791916/diclofenac-sodium-3-in-hyaluronic-acid-2-5-gel-significantly-diminishes-the-actinic-keratosis-area-and-severity-index
#3
Lutz Schmitz, Girish Gupta, Marc Hanno Segert, Ricarda Kost, Julia Sternberg, Thilo Gambichler, Eggert Stockfleth, Thomas Dirschka
BACKGROUND/AIMS: Actinic keratosis area and severity index (AKASI) is a new assessment tool to quantify the severity of actinic damage on the head. Thus far, it has not been evaluated in monitoring the efficacy of field-directed topical treatments in actinic keratosis (AK) in routine clinical practice. Thus, the aim of this study was to determine treatment outcomes by using AKASI 3 months after the initiation of topical application of diclofenac sodium 3% in hyaluronic acid 2.5% gel (DFS) in patients with AKs on the head...
May 23, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29790604/synthesis-of-dihydroxyalkynyl-and-dihydroxyalkyl-nucleotides-as-building-blocks-or-precursors-for-introduction-of-diol-or-aldehyde-functions-to-dna-for-bioconjugations
#4
Matouš Krömer, Kateřina Bártová, Veronika Raindlová, Michal Hocek
(3,4-Dihydroxybut-1-ynyl)uracil, -cytosine and -7-deazaadenine 2'-deoxyribonucleoside triphosphates (dNTPs) were prepared by direct aqueous Sonogashira cross-coupling of halogenated dNTPs with dihydroxybut-1-yne and converted to 3,4-dihydroxybutyl dNTPs through catalytic hydrogenation. Sodium periodate oxidative cleavage of dihydroxybutyl-dUTP gave the desired aliphatic aldehyde-linked dUTP, whereas the oxidative cleavage of the corresponding deazaadenine dNTP gave a cyclic aminal. All dihydroxyalkyl or -alkynyl dNTPs and the formylethyl-dUTP were good substrates for DNA polymerases and were used for synthesis of diol- or aldehyde-linked DNA...
May 23, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29789348/gestational-low-protein-intake-enhances-whole-kidney-mir-192-and-mir-200-family-expression-and-epithelial-to-mesenchymal-transition-in-rat-adult-male-offspring
#5
Letícia B Sene, Victor Hugo Gonçalves Rizzi, José A R Gontijo, Patricia A Boer
Studies have shown that adult offspring of mothers fed a protein-restricted diet during pregnancy present a pronounced reduction of nephron number associated with decreased fractional urinary sodium excretion and arterial hypertension. Additionally, recent advances in our understanding of the molecular pathways that govern the association of gestational nutritional restriction, intrauterine growth retardation and inflammation with impaired nephrogenesis, nephron underdosing and kidney fibrosis point to the epithelial to mesenchymal transition (EMT) as a common factor...
May 22, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29788266/dietary-magnesium-alleviates-experimental-murine-colitis-through-upregulation-of-the-transient-receptor-potential-melastatin-6-channel
#6
Valentina Trapani, Valentina Petito, Angelica Di Agostini, Daniela Arduini, Willem Hamersma, Giuseppe Pietropaolo, Francesca Luongo, Vincenzo Arena, Egidio Stigliano, Loris R Lopetuso, Antonio Gasbarrini, Federica I Wolf, Franco Scaldaferri
Background: Magnesium (Mg) is essential for human health and is absorbed mainly in the intestine. In view of the likely occurrence of an Mg deficit in inflammatory bowel disease (IBD) and the documented role of Mg in modulating inflammation, the present study addresses whether Mg availability can affect the onset and progression of intestinal inflammation. Methods: To study the correlation between Mg status and disease activity, we measured magnesemia by atomic absorption spectroscopy in a cohort of IBD patients...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29787972/investigation-by-direct-infusion-esi-ms-and-gc-ms-of-an-alleged-leuckart-route-specific-impurity-of-methamphetamine
#7
Ethan M McBride, Guido F Verbeck
Impurity profiling has been used as a useful tool for analyzing nearly every drug class currently known on the illicit market. Impurities present within seized samples have the potential to determine source of origin, route of synthesis used, as well as provide a useful clue into the potential reaction mechanisms that are present for each synthetic procedure. Perhaps the most well studied of these impurity profiles exists for methamphetamine, including information to more than one route of synthesis. Within the present study, a complete synthesis of methamphetamine was performed, including a reductive amination of phenylpropanone (P2P) using methylamine hydrochloride and sodium triacetoxyborohydride (STAB) rather than the conventional aluminum mercury amalgam commonly found in the literature...
May 16, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29787238/anti-fibrotic-effect-of-ketoprofen-grafted-alginate-microcapsules-in-the-transplantation-of-insulin-producing-cells
#8
François Noverraz, Elisa Montanari, Joël Pimenta, Luca Szabo, Daniel Ortiz, Carmen Gonelle-Gispert, Léo Bühler, Sandrine Gerber-Lemaire
The controlled release of small molecular modulators of the immune response from hydrogel microspheres (MS) used for cell immobilization is an attractive approach to reduce pericapsular fibrotic overgrowth (PFO) after transplantation. Ketoprofen is a well-known non-steroidal anti-inflammatory drug involved in the early stage inflammation cascade. PEGylated derivatives of ketoprofen, presenting either ester or amide linkage to the drug, were synthesized and conjugated to the hydroxyl groups of sodium alginate (Na-alg)...
May 22, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29785969/pillared-graphite-anodes-for-reversible-sodiation
#9
Hanyang Zhang, Zhifei Li, Wei Xu, Yicong Chen, Xiulei Ji, Michael M Lerner
There has been a major effort recently to develop new rechargeable sodium-ion electrodes. In lithium ion batteries, LiC6 forms from graphite and de-solvated Li cations during the first charge. With sodium ions, graphite only shows a significant capacity when Na+ intercalates as a solvated complex, resulting in ternary graphite intercalation compounds (GICs). Although this chemistry has been shown to be highly reversible and to support high rates in small test cells, these GICs can require >250% volume expansion and contraction during cycling...
May 22, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29785595/a-preliminary-investigation-on-water-quality-of-coalbed-natural-gas-produced-water-for-beneficial-uses-a-case-study-in-the-southern-qinshui-basin-north-china
#10
Zheng Zhang, Yong Qin
Coalbed natural gas (CBNG) is an important unconventional natural gas resource with large reserves in China and receives much attention these years. The CBNG production is accomplished by extracting large volumes of produced water from the aquifer. The CBNG-produced water is commonly managed by discharging into nearby disposal ponds in the Southern Qinshui Basin (SQB), which provides an opportunity for water source for nearby irrigation, livestock, wildlife, and human drinking water. However, utilization of this nontraditional water source in the SQB is hindered by limited knowledge of water quality, practically oxidation/reduction potential (OPR), electrical conductivity (EC), sodium adsorption ration (SAR), and trace element chemistry data...
May 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29785515/prostate-specific-antigen-flare-induced-by-223-racl-2-in-patients-with-metastatic-castration-resistant-prostate-cancer
#11
Angelo Castello, H A Macapinlac, E Lopci, E B Santos
PURPOSE: Prostate-specific antigen (PSA) flare is a well-known phenomenon in patients with prostate cancer, but its impact during radium-223 dichloride (223 RaCl2 ) therapy is still unclear. This radioisotope has shown to improve overall survival in metastatic castration-resistant prostate cancer (mCRPC). We sought to evaluate the impact of PSA flare on survival and its relation with metabolic parameters on 18 F-labeled sodium fluoride PET/CT. METHODS: We conducted a retrospective study of 168 patients with mCRPC (median age 69; median PSA 29...
May 21, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29784352/application-of-gradient-ratio-flow-injection-technique-to-implementation-of-the-chemical-h-point-standard-addition-method
#12
Marcin Wieczorek, Marek Dębosz, Paweł Świt, Aneta Woźniakiewicz, Paweł Kościelniak
A new gradient ratio approach to Chemical H-point Standard Addition Method (C-HPSAM) was developed in flow injection analysis with spectrophotometric detection. C-HPSAM is based on an idea to use SAM for calibration in several different chemical conditions in order to correct unspecific (additive) interferences in samples with unknown matrix. The approach proposed in this paper employs the gradient ratio flow-injection technique to generate a continuous change of chemical conditions. By doing so a set of two-point SAM calibration curves with different slopes are possible of registering that are intersected in a common point indicating the values of both unspecific interferences and analyte concentration in a sample...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29783625/a-simple-alternative-method-for-preservation-of-2-methylisoborneol-in-water-samples
#13
Chun-Cheng Fan, Yi-Ting Chiu, Tsair-Fuh Lin
2-Methylisoborneol (2-MIB) is one of the most commonly observed taste and odor (T&O) compounds present in drinking water sources. As it is biodegradable, a preservation agent, typically mercury chloride, is needed if the water is not analyzed right after sampling. Since mercury is a toxic metal, an alternative chemical that is cheaper and less toxic is desirable. In this study, two chemicals commonly used in water treatment processes, chlorine (as sodium hypochlorite) and KMnO₄ (potassium permanganate), are studied to determine their feasibility as preservation agents for 2-MIB in water...
May 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29783129/effect-of-surfactant-assisted-sonic-pretreatment-on-liquefaction-of-fruits-and-vegetable-residue-characterization-acidogenesis-biomethane-yield-and-energy-ratio
#14
M Shanthi, J Rajesh Banu, P Sivashanmugam
The present study explored the disintegration potential of fruits and vegetable residue through sodium dodecyl sulphate (SDS) assisted sonic pretreatment (SSP). In SSP method, initially the biomass barrier (lignin) was removed using SDS at different dosage, subsequently it was sonically disintegrated. The effect of SSP were assessed based on dissolved organic release (DOR) of fruits and vegetable waste and specific energy input. SSP method achieved higher DOR rate and suspended solids reduction (26% and 16%) at optimum SDS dosage of 0...
May 15, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29782141/in-situ-assembly-of-well-dispersed-ag-nanoparticles-throughout-electrospun-alginate-nanofibers-for-monitoring-human-breath-smart-fabrics
#15
Jun Zhang, Xiao-Xiong Wang, Bin Zhang, Seeram Ramakrishna, Miao Yu, Jian-Wei Ma, Yun-Ze Long
Alginate nanofibers assembled with sliver nanoparticles throughout the whole nanofiber were fabricated by three steps including electrospinning of Na-alginate nanofibers, ion exchange between the sodium and silver ions, and in situ reduction of silver nanoparticles. The content, distribution and size of the nanoparticles are controllable by tuning reaction conditions. Ag/alginate nanofibers exhibit good humidity sensitivity in a wide humidity range from ambient RH (20%) to 85% RH. Interestingly, these humidity sensors can be attached to a 3M-9001V mask for monitoring human breath during exercise and emotion changes, and this smart exhibits accurate and continuous human-breath tracking no matter how fast or slow as well as how deep or shallow...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29780433/influence-of-metal-deposition-and-activation-method-on-the-structure-and-performance-of-carbon-nanotube-supported-palladium-catalysts
#16
Wouter S Lamme, Jovana Zečević, Krijn P de Jong
The effects of the metal deposition and activation methods on metal particle size and distribution were investigated for carbon nanotube supported Pd catalysts. The Pd precursor was loaded by incipient wetness impregnation, ion adsorption, and deposition precipitation and was activated by thermal treatment under a nitrogen atmosphere or in the liquid phase by reduction by formaldehyde or sodium borohydride. Regardless of the metal precursor loading method, activation under a N2 atmosphere at 500 °C led to homogeneously distributed 4 nm Pd particles...
April 9, 2018: ChemCatChem
https://www.readbyqxmd.com/read/29779467/calcium-sodium-and-trp-channel-expression-in-human-fetal-midbrain-derived-neural-progenitor-cells
#17
Nancy Stanslowsky, Salini Tharmarasa, Selma Staege, Norman Kalmbach, Martin Klietz, Sigrid Schwarz, Andreas Leffler, Florian Wegner
Voltage-gated sodium and calcium channels as well as transient receptor potential (TRP) channels are expressed during the differentiation of human neural progenitor cells (hNPCs) and are likely to be involved in regulating neurogenesis. However, the molecular composition of these ion channels in proliferating and differentiating hNPCs is largely unknown. Here, we investigated fetal mesencephalic hNPCs in respect to their sodium, calcium, and TRP channel subunit expression and function. Quantitative real-time PCR indicated a significant upregulation of voltage-gated sodium and calcium channel subunits in hNPCs after differentiation for 3 weeks in vitro...
May 19, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29778846/efficacy-and-tolerability-of-treatment-with-lacosamide-postmarketing-experience-from-the-middle-east-region
#18
Maher Arabi, Taoufik Alsaadi, Wassim Nasreddine, Jasem Al-Hashel, Maya Dirani, Ahmad Beydoun
PURPOSE: Lacosamide (LCM) was recently introduced in the Middle East. The aim of this study was to evaluate the safety, tolerability, and efficacy of LCM in patients with focal onset seizures and determine if our results are comparable with those derived from Western countries. METHODS: This is a retrospective analysis from two medical centers on consecutive patients diagnosed as having focal onset seizures and treated with add-on LCM. The primary efficacy variables were the 50% responder and seizure-free rates, and the secondary outcome variables included the percentages of patients who achieved seizure remission during the last 6-month follow-up period and the percentages of discontinuation due to lack of efficacy or tolerability...
May 17, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29777815/enhanced-antibacterial-activity-mechanical-and-physical-properties-of-alginate-hydroxyapatite-bionanocomposite-film
#19
Bahador Safikhani Gholizadeh, Foad Buazar, Seyed Mehdi Hosseini, Seyed Mohammad Mousavi
The effect of hydroxyapatite nanoparticles (HA NPs) contents on the antibacterial activity, physical, and mechanical properties of sodium alginate (SA) film was scrutinized. The samples were prepared via incorporation of three different concentrations of HA NPs (1%, 3%, and 5%) into alginate solution at ambient temperature. In all SA/HA matrices, HA NPs demonstrated considerable bactericidal activity against foodborne pathogen during 12 days. The highest antibacterial effect of SA film was obtained in the presence of 5%HA NPs content and showed 3 CFU/mg reduction...
May 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29777264/empagliflozin-reduces-cardiovascular-events-mortality-and-renal-events-in-participants-with-type-2-diabetes-after-coronary-artery-bypass-graft-surgery-subanalysis-of-the-empa-reg-outcome%C3%A2-randomised-trial
#20
Subodh Verma, C David Mazer, David Fitchett, Silvio E Inzucchi, Egon Pfarr, Jyothis T George, Bernard Zinman
AIMS/HYPOTHESIS: After coronary artery bypass graft (CABG) surgery in individuals with type 2 diabetes, there remains a considerable residual cardiovascular risk. In the EMPA-REG OUTCOME® trial in participants with type 2 diabetes and established cardiovascular disease, empagliflozin reduced the risk of cardiovascular death by 38%, all-cause mortality by 32%, hospitalisation for heart failure by 35% and incident or worsening nephropathy by 39% vs placebo when given in addition to standard of care...
May 19, 2018: Diabetologia
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