keyword
https://read.qxmd.com/read/38525637/progress-towards-90-90-90-and-95-95-95-strategy-implementations-and-hiv-positivity-trends-in-the-city-of-johannesburg
#21
JOURNAL ARTICLE
J C Y Nyasulu, I Maposa
BACKGROUND: The 95-95-95 strategy implementation is a positive initiative for moving the HIV tide towards elimination, with a focus on addressing the huge inequalities in existence in access to HIV services. OBJECTIVES: To establish performance towards the 90-90-90 and 95-95-95 targets and trends in HIV positivity rates since strategy implementation rollout in the City of Johannesburg (CoJ), South Africa. METHODS: This was a descriptive study, part of the bigger quasi-experimental study using the monthly District Health Information System during the implementation and rollout of the 90-90-90 strategy...
December 31, 2023: South African Medical Journal
https://read.qxmd.com/read/38525192/mendelian-randomization-supports-genetic-liability-to-hospitalization-for-covid-19-as-a-risk-factor-of-pre-eclampsia
#22
JOURNAL ARTICLE
Weizhen Wu, Junning Zhang, Yizhuo Qiao, Yuehan Ren, Xuezhi Rao, Zhijie Xu, Baoxing Liu
BACKGROUND: Pre-eclampsia and eclampsia are among the major threats to pregnant women and fetuses, but they can be mitigated by prevention and early screening. Existing observational research presents conflicting evidence regarding the causal effects of coronavirus disease 2019 (COVID-19) on pre-eclampsia risk. Through Mendelian randomization (MR), this study aims to investigate the causal effect of three COVID-19 severity phenotypes on the risk of pre-eclampsia and eclampsia to provide more rigorous evidence...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38524155/healthcare-utilization-and-clinical-characteristics-of-genetic-epilepsy-in-electronic-health-records
#23
JOURNAL ARTICLE
Christian M Boßelmann, Alina Ivaniuk, Mark St John, Sara C Taylor, Gokul Krishnaswamy, Alex Milinovich, Costin Leu, Ajay Gupta, Elia M Pestana-Knight, Imad Najm, Dennis Lal
Understanding the clinical characteristics and medical treatment of individuals affected by genetic epilepsies is instrumental in guiding selection for genetic testing, defining the phenotype range of these rare disorders, optimizing patient care pathways and pinpointing unaddressed medical need by quantifying healthcare resource utilization. To date, a matched longitudinal cohort study encompassing the entire spectrum of clinical characteristics and medical treatment from childhood through adolescence has not been performed...
2024: Brain communications
https://read.qxmd.com/read/38522078/impaired-neuronal-macroautophagy-in-the-prelimbic-cortex-contributes-to-comorbid-anxiety-like-behaviors-in-rats-with-chronic-neuropathic-pain
#24
JOURNAL ARTICLE
Su Fu, Haojie Sun, Jiaxin Wang, Shuaixin Gao, Liu Zhu, Kun Cui, Shimeng Liu, Xuetao Qi, Rui Guan, Xiaocen Fan, Qingying Liu, Wen Chen, Li Su, Shuang Cui, Feifei Liao, Fengyu Liu, Catherine C L Wong, Ming Yi, You Wan
A large proportion of patients with chronic pain experience co-morbid anxiety. The medial prefrontal cortex (mPFC) is proposed to underlie this comorbidity, but the molecular and neuronal mechanisms are not fully understood. Here, we reported that impaired neuronal macroautophagy in the prelimbic cortical (PrL) subregion of the mPFC paralleled the occurrence of anxiety-like behaviors in rats with chronic spared nerve injury (SNI). Intriguingly, such macroautophagy impairment was mainly observed in a FOS/c-Fos+ neuronal subpopulation in the PrL...
March 24, 2024: Autophagy
https://read.qxmd.com/read/38521854/association-of-the-fat-mass-index-with-hepatic-steatosis-and-fibrosis-evidence-from-nhanes-2017-2018
#25
JOURNAL ARTICLE
Lihe Liu, Jiaxi Lin, Minyue Yin, Lu Liu, Jingwen Gao, Xiaolin Liu, Jinzhou Zhu, Airong Wu
Limited population-based studies discuss the association between fat mass index (FMI) and the risk of liver diseases. This investigation utilized data from the National Health and Nutrition Examination Survey (NHANES) to examine the linkage between the FMI and liver conditions, specifically steatosis and fibrosis. The study leveraged data from NHANES's 2017-2018 cross-sectional study, employing an oversampling technique to deal with sample imbalance. Hepatic steatosis and fibrosis were identified by vibration-controlled transient elastography...
March 23, 2024: Scientific Reports
https://read.qxmd.com/read/38520142/development-and-external-validation-of-the-efalls-tool-a-multivariable-prediction-model-for-the-risk-of-ed-attendance-or-hospitalisation-with-a-fall-or-fracture-in-older-adults
#26
JOURNAL ARTICLE
Lucinda Archer, Samuel D Relton, Ashley Akbari, Kate Best, Milica Bucknall, Simon Conroy, Miriam Hattle, Joe Hollinghurst, Sara Humphrey, Ronan A Lyons, Suzanne Richards, Kate Walters, Robert West, Danielle van der Windt, Richard D Riley, Andrew Clegg
BACKGROUND: Falls are common in older adults and can devastate personal independence through injury such as fracture and fear of future falls. Methods to identify people for falls prevention interventions are currently limited, with high risks of bias in published prediction models. We have developed and externally validated the eFalls prediction model using routinely collected primary care electronic health records (EHR) to predict risk of emergency department attendance/hospitalisation with fall or fracture within 1 year...
March 1, 2024: Age and Ageing
https://read.qxmd.com/read/38519358/-evidence-based-practice-in-bachelor-of-nursing-programmes-in-austria-germany-and-switzerland-a-survey-of-general-conditions-teaching-content-and-methods
#27
JOURNAL ARTICLE
Peter Jäger, Julian Hirt, Thomas Nordhausen, Janine Vetsch, Katrin Balzer, Martin N Dichter, Gerhard Müller, Angelika Schley, Stefanie Neyer
BACKGROUND/AIM: Evidence-based practice (EBP) provides an important basis for improving both the quality of care and patient safety. Formulating a research question, searching the literature, and critical appraisal are crucial to developing evidence-based practice. The aim of this survey was to provide an overview of how these topics are integrated into bachelor's degree programs in nursing in Austria, Germany, and the German-speaking part of Switzerland. We also aimed to show how teachers implement these subjects and how they experience and assess the implementation...
March 21, 2024: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://read.qxmd.com/read/38519152/machine-learning-enabled-maternal-risk-assessment-for-women-with-pre-eclampsia-the-piers-ml-model-a-modelling-study
#28
JOURNAL ARTICLE
Tünde Montgomery-Csobán, Kimberley Kavanagh, Paul Murray, Chris Robertson, Sarah J E Barry, U Vivian Ukah, Beth A Payne, Kypros H Nicolaides, Argyro Syngelaki, Olivia Ionescu, Ranjit Akolekar, Jennifer A Hutcheon, Laura A Magee, Peter von Dadelszen
BACKGROUND: Affecting 2-4% of pregnancies, pre-eclampsia is a leading cause of maternal death and morbidity worldwide. Using routinely available data, we aimed to develop and validate a novel machine learning-based and clinical setting-responsive time-of-disease model to rule out and rule in adverse maternal outcomes in women presenting with pre-eclampsia. METHODS: We used health system, demographic, and clinical data from the day of first assessment with pre-eclampsia to predict a Delphi-derived composite outcome of maternal mortality or severe morbidity within 2 days...
April 2024: The Lancet. Digital health
https://read.qxmd.com/read/38517698/ddk-linker-a-network-based-strategy-identifies-disease-signals-by-linking-high-throughput-omics-datasets-to-disease-knowledge
#29
JOURNAL ARTICLE
Xiangren Kong, Lihong Diao, Peng Jiang, Shiyan Nie, Shuzhen Guo, Dong Li
The high-throughput genomic and proteomic scanning approaches allow investigators to measure the quantification of genome-wide genes (or gene products) for certain disease conditions, which plays an essential role in promoting the discovery of disease mechanisms. The high-throughput approaches often generate a large gene list of interest (GOIs), such as differentially expressed genes/proteins. However, researchers have to perform manual triage and validation to explore the most promising, biologically plausible linkages between the known disease genes and GOIs (disease signals) for further study...
January 22, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38517693/rehogcnes-mda-prediction-of-mirna-disease-associations-using-homogenous-graph-convolutional-networks-based-on-regular-graph-with-random-edge-sampler
#30
JOURNAL ARTICLE
Yufang Zhang, Yanyi Chu, Shenggeng Lin, Yi Xiong, Dong-Qing Wei
Numerous investigations increasingly indicate the significance of microRNA (miRNA) in human diseases. Hence, unearthing associations between miRNA and diseases can contribute to precise diagnosis and efficacious remediation of medical conditions. The detection of miRNA-disease linkages via computational techniques utilizing biological information has emerged as a cost-effective and highly efficient approach. Here, we introduced a computational framework named ReHoGCNES, designed for prospective miRNA-disease association prediction (ReHoGCNES-MDA)...
January 22, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38515801/who-are-pacific-peoples-in-terms-of-ethnicity-and-country-of-birth-a-cross-sectional-study-of-2-238-039-adults-in-aotearoa-new-zealand-s-integrated-data-infrastructure
#31
JOURNAL ARTICLE
Julie Winter-Smith, Corina Grey, Janine Paynter, Matire Harwood, Vanessa Selak
BACKGROUND: The aggregation of Indigenous peoples from Pacific Island nations as 'Pacific peoples' in literature may mask diversity in the health needs of these different groups. The aim of this study was to examine the heterogeneity of Pacific groups according to ethnicity and country of birth. METHODS: Anonymised individual-level linkage of administrative data identified all NZ residents aged 30-74 years on 31 March 2013 with known ethnicity and country of birth...
December 2023: Dialogues Health
https://read.qxmd.com/read/38515693/differences-and-relationships-between-talent-detection-identification-development-and-selection-in-sport-a-systematic-review
#32
JOURNAL ARTICLE
Jie Zhao, Changqing Xiang, Tengku Fadilah Tengku Kamalden, Wenting Dong, Hua Luo, Normala Ismail
Although there are numerous studies on talent, especially talent identification, development, and selection, both on influencing factors and model construction or talent prediction, they have relatively independently explored some of its stages. Undeniably, talent development is continuous and phased, with specific tasks to be completed at each step, and these steps have certain differences and relationships. The aim of this review is to provide a clear distinction between the entire talent cultivation process, with the purpose of having better methods and measures for each stage to minimize the turnover rate and ensure the integrity of the talent development process...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38514927/the-association-between-genetic-polymorphisms-of-matrix-metalloproteinases-and-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#33
REVIEW
Xu Jiang, Qianqian Wang, Chao Wang, Yanzhuo Zhang, Zhenjie Wei, Zhimin Wu, Shunan Yu, Chengai Wu
AIM: To investigate the linkage of matrix metalloproteinase (MMP) gene polymorphisms with the pathogenesis of knee osteoarthritis (OA). METHODS: This meta-analysis study systematically retrieved relevant studies from PubMed, Embase, the Cochrane Central, Wanfang Data, CNKI, and SinoMed up to November 2020. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association between MMP gene polymorphisms and OA. RESULTS: A total of nine case-control studies comprising 1719 knee OA patients and 1904 controls were included in this meta-analysis...
March 2024: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/38513549/assessment-of-selective-breeding-effects-and-selection-signatures-in-qingyuan-partridge-chicken-and-its-strains
#34
JOURNAL ARTICLE
Shaofen Kong, Bolin Cai, Xiaojing Li, Zhen Zhou, Xiang Fang, Xin Yang, Danfeng Cai, Xuehui Luo, Suyin Guo, Qinghua Nie
Qingyuan partridge chicken (QYM) is a highly regarded native breed in China, highly esteemed for its exceptional breeding characteristics. However, the investigation into the selection signatures and its strains remains largely unexplored. In this study, blood sampling, DNA extracting, and high-depth resequencing were performed in 27 QYMs. Integrating the genomic data of 14 chicken (70 individuals) breeds from other researches, to analyze the genetic structure, selection signatures, and effects of selective breeding within QYM and its 3 strains (QYMA, QYMB, and QYMC)...
March 6, 2024: Poultry Science
https://read.qxmd.com/read/38513161/cancer-treatment-disparities-in-people-with-hiv-in-the-united-states-2001-2019
#35
JOURNAL ARTICLE
Jennifer K McGee-Avila, Gita Suneja, Eric A Engels, Anne F Rositch, Marie-Josephe Horner, Qianlai Luo, Meredith S Shiels, Jessica Y Islam
PURPOSE: People with HIV (PWH) have worse cancer outcomes, partially because of inequities in cancer treatment. We evaluated cancer treatment disparities among PWH, including an assessment of changes in disparities over time. METHODS: We used data from the HIV/AIDS Cancer Match Study, a population-based HIV and cancer registry linkage to examine diffuse large B-cell lymphoma (DLBCL), Hodgkin lymphoma (HL), and cancers of the cervix, lung, anus, prostate, colon, and female breast...
March 21, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38513072/point-of-care-testing-for-hepatitis-c-in-the-priority-settings-of-mental-health-prisons-and-drug-alcohol-facilities-the-prompt-study
#36
JOURNAL ARTICLE
Erin M McCartney, Lucy Ralton, Joshua Dawe, Jacqui Richmond, Joshua Zobel, Alan Wigg, Victoria Cock, Edmund Y Tse, Tom Rees, David Shaw, Catherine Ferguson
BACKGROUND: A barrier to hepatitis C virus (HCV) cure is conventional testing. The aim of this study was to evaluate the effect of HCV antibody and RNA point-of-care-testing (POCT) on testing rates, linkage to care, treatment and acceptability of testing in three priority settings in Australia. METHODS: Participants were enrolled in an interventional cohort study at a reception prison, inpatient mental health service (MHS), and inpatient alcohol and other drug (AOD) unit-between October 2020 and December 2021...
March 21, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38512523/prevalence-and-temporal-relationship-of-clinical-co-morbidities-in-idiopathic-dystonia-a-uk-linkage-based-study
#37
JOURNAL ARTICLE
Grace A Bailey, Anna Rawlings, Fatemeh Torabi, W Owen Pickrell, Kathryn J Peall
While motor and psychiatric phenotypes in idiopathic dystonia are increasingly well understood, a few studies have examined the rate, type, and temporal pattern of other clinical co-morbidities in dystonia. Here, we determine the rates of clinical diagnoses across 13 broad systems-based diagnostic groups, comparing an overall idiopathic dystonia cohort, and sub-cohorts of cervical dystonia, blepharospasm, and dystonic tremor, to a matched-control cohort. Using the SAIL databank, we undertook a longitudinal population-based cohort study (January 1st 1994-December 31st 2017) using anonymised electronic healthcare records for individuals living in Wales (UK), identifying those diagnosed with dystonia through use of a previously validated algorithm...
March 21, 2024: Journal of Neurology
https://read.qxmd.com/read/38510920/high-hiv-diversity-recombination-and-superinfection-revealed-in-a-large-outbreak-among-persons-who-inject-drugs-in-kentucky-and-ohio-usa
#38
JOURNAL ARTICLE
William M Switzer, Anupama Shankar, Hongwei Jia, Sergey Knyazev, Frank Ambrosio, Reagan Kelly, HaoQiang Zheng, Ellsworth M Campbell, Roxana Cintron, Yi Pan, Neeraja Saduvala, Nivedha Panneer, Rhiannon Richman, Manny B Singh, Douglas A Thoroughman, Erin F Blau, George M Khalil, Sheryl Lyss, Walid Heneine
We investigated transmission dynamics of a large human immunodeficiency virus (HIV) outbreak among persons who inject drugs (PWID) in KY and OH during 2017-20 by using detailed phylogenetic, network, recombination, and cluster dating analyses. Using polymerase ( pol ) sequences from 193 people associated with the investigation, we document high HIV-1 diversity, including Subtype B (44.6 per cent); numerous circulating recombinant forms (CRFs) including CRF02_AG (2.5 per cent) and CRF02_AG-like (21...
2024: Virus Evolution
https://read.qxmd.com/read/38509588/sglt2-inhibition-high-density-lipoprotein-and-kidney-function-a-mendelian-randomization-study
#39
JOURNAL ARTICLE
Zhijuan Wang, Jie Wei, Wenman Zhao, Rui Shi, Yuyu Zhu, Xunliang Li, Deguang Wang
BACKGROUND: Sodium-glucose cotransporter 2 (SGLT2) inhibition is recognized for its evident renoprotective benefits in diabetic renal disease. Recent data suggest that SGLT2 inhibition also slows down kidney disease progression and reduces the risk of acute kidney injury, regardless of whether the patient has diabetes or not, but the mechanism behind these observed effects remains elusive. The objective of this study is to utilize a mendelian randomization (MR) methodology to comprehensively examine the influence of metabolites in circulation regarding the impact of SGLT2 inhibition on kidney function...
March 20, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38509403/population-neuroscience-strategies-to-promote-data-sharing-while-protecting-privacy
#40
JOURNAL ARTICLE
Adrian Thorogood
Population neuroscience aims to advance our understanding of how genetic and environmental factors influence brain development and brain health over the life span, by integrating genomics, epidemiology, and neuroscience at population scale. This big data approach depends on data sharing strategies at both the micro- and macro-level, as well as attention to effective data management and protection of participant privacy. At the micro-level, researchers participate in international consortia that support collaboration, standards, and data sharing...
March 21, 2024: Current Topics in Behavioral Neurosciences
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