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https://www.readbyqxmd.com/read/28739187/fluidity-of-the-dietary-fatty-acid-profile-and-risk-of-coronary-heart-disease-and-ischemic-stroke-results-from-the-epic-netherlands-cohort-study
#1
I Sluijs, J Praagman, J M A Boer, W M M Verschuren, Y T van der Schouw
BACKGROUND AND AIMS: The fluidity of dietary fatty acids consumed has been suggested to inversely affect coronary heart disease (CHD) risk. Lipophilic index (LI) represents overall fluidity of the dietary fatty acid profile. Lipophilic load (LL) represents a combination of overall fluidity and absolute intake of dietary fatty acids. We investigated the relations of dietary LI and LL with risk of CHD and ischemic stroke (iStroke). METHODS AND RESULTS: We used data from the prospective EPIC-NL study, including 36,520 participants aged 20-70 years...
June 21, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28738914/characterization-of-group-b-coxsackieviruses-isolated-from-non-polio-acute-flaccid-paralysis-patients-in-pakistan-vital-assessment-before-polio-eradication
#2
M Angez, S Shaukat, R Zahra, M M Alam, S Sharif, A Khurshid, Y Arshad, M Suleman, G Mujtaba, S S Z Zaidi
Pakistan is at the verge of polio eradication but isolation of non-polio enteroviruses (NPEVs) from acute flaccid paralysis (AFP) cases may result in serious or even fatal outcome. Many enteroviruses share similar symptoms and epidemiology as is the case with poliovirus and coxsackievirus (CV). The present study was designed to genetically characterize coxsackievirus B (CV-B) serotypes isolated from non-polio acute flaccid paralytic children, as well as to understand their probable role in paralysis. A total of 63 (20·1%) out of 313 stool samples during 2013 were found positive for NPEVs in rhabdomyosarcoma cells...
July 25, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28736898/identification-of-positive-selection-signatures-in-pigs-by-comparing-linkage-disequilibrium-variances
#3
X Li, S Yang, K Dong, Z Tang, K Li, B Fan, Z Wang, B Liu
Selection affects the patterns of linkage disequilibrium (LD) around the site of a beneficial allele with an increase in LD among the hitchhiking alleles. Comparing the differences in regional LD between pig populations could help to identify putative genomic regions with potential adaptations for economic traits. In this study, using Illumina Porcine SNP60K BeadChip genotyping data from 207 Chinese indigenous, 117 South American village and 408 Large White pigs, we estimated the variation of genome-wide LD between populations using the varld program...
July 23, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28735246/nurses-reports-of-staffing-adequacy-and-surgical-site-infections-a-cross-sectional-multi-centre-study
#4
Christine Tvedt, Ingeborg Strømseng Sjetne, Jon Helgeland, Hege Line Løwer, Geir Bukholm
BACKGROUND: It is indicated that healthcare personnel's perceptions of the work environment may reflect the clinical outcomes for the patients they care for. However, the body of evidence is inconsistent when it comes to the association between work environment and surgical site infection. OBJECTIVES: The aim of this study is to examine the associations between nurse-reported characteristics of the work environment and incidence of surgical site infections after total hip arthroplasty...
July 14, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28734057/major-life-events-and-risk-of-alcohol-use-disorders-a-prospective-cohort-study
#5
Emilie Just-Østergaard, Erik L Mortensen, Trine Flensborg-Madsen
AIMS: To estimate associations of individual major life events as well as accumulated major life events in childhood, adult private life and adult work life with risk of alcohol use disorders (AUD). DESIGN: Prospective cohort study with baseline examination in 1991-93 and linkage to national registers to identify AUD at follow-up. SETTING: Copenhagen, Denmark. PARTICIPANTS: Individuals (aged 21 to 93 years) who participated in the Copenhagen City Heart Study in 1991-93 (n=8,758)...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28733817/enriching-an-intraspecific-genetic-map-and-identifying-qtl-for-fiber-quality-and-yield-component-traits-across-multiple-environments-in-upland-cotton-gossypium-hirsutum-l
#6
Xueying Liu, Zhonghua Teng, Jinxia Wang, Tiantian Wu, Zhiqin Zhang, Xianping Deng, Xiaomei Fang, Zhaoyun Tan, Iftikhar Ali, Dexin Liu, Jian Zhang, Dajun Liu, Fang Liu, Zhengsheng Zhang
Cotton is a significant commercial crop that plays an indispensable role in many domains. Constructing high-density genetic maps and identifying stable quantitative trait locus (QTL) controlling agronomic traits are necessary prerequisites for marker-assisted selection (MAS). A total of 14,899 SSR primer pairs designed from the genome sequence of G. raimondii were screened for polymorphic markers between mapping parents CCRI 35 and Yumian 1, and 712 SSR markers showing polymorphism were used to genotype 180 lines from a (CCRI 35 × Yumian 1) recombinant inbred line (RIL) population...
July 21, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28732466/estimation-of-linkage-disequilibrium-and-effective-population-size-in-new-zealand-sheep-using-three-different-methods-to-create-genetic-maps
#7
Vincent Prieur, Shannon M Clarke, Luiz F Brito, John C McEwan, Michael A Lee, Rudiger Brauning, Ken G Dodds, Benoît Auvray
BACKGROUND: Investments in genetic selection have played a major role in the New Zealand sheep industry competitiveness. Selection may erode genetic diversity, which is a crucial factor for the success of breeding programs. Better understanding of linkage disequilibrium (LD) and ancestral effective population size (Ne) through quantifying this diversity and comparison between populations allows for more informed decisions with regards to selective breeding taking population genetic diversity into account...
July 21, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28732294/soil-bacterial-community-response-to-vegetation-succession-after-fencing-in-the-grassland-of-china
#8
Quanchao Zeng, Shaoshan An, Yang Liu
Natural succession is an important process in terrestrial system, playing an important role in enhancing soil quality and plant diversity. Soil bacteria is the linkage between soil and plant, has an important role in aboveground community dynamics and ecosystem functioning in terrestrial ecosystems, driving the decomposition of soil organic matter and plant litter. However, the role of soil bacteria in the secondary succession has not been well understood, particularly in the degraded soil of Loess Plateau...
July 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28731961/joint-effect-of-alcohol-consumption-and-educational-level-on-alcohol-related-medical-events-a-danish-register-based-cohort-study
#9
Helene Nordahl Christensen, Finn Diderichsen, Ulla Arthur Hvidtfeldt, Theis Lange, Per Kragh Andersen, Merete Osler, Eva Prescott, Anne Tjønneland, Naja Hulvej Rod, Ingelise Andersen
BACKGROUND: Alcohol-related mortality is more pronounced in lower than higher socioeconomic groups in Western countries. Part of the explanation is differences in drinking patterns. However, differences in vulnerability to health consequences of alcohol consumption across socioeconomic groups may also play a role. We investigated the joint effect of alcohol consumption and educational level on the rate of alcohol-related medical events. METHODS: We pooled seven prospective cohorts from Denmark that enrolled 74 278 men and women aged 30-70 years (study period 1981 to 2009)...
July 19, 2017: Epidemiology
https://www.readbyqxmd.com/read/28731893/validity-of-administrative-data-in-identifying-cancer-related-events-in-adolescents-and-young-adults-a-population-based-study-using-the-impact-cohort
#10
Sumit Gupta, Paul C Nathan, Nancy N Baxter, Cindy Lau, Corinne Daly, Jason D Pole
BACKGROUND: Despite the importance of estimating population level cancer outcomes, most registries do not collect critical events such as relapse. Attempts to use health administrative data to identify these events have focused on older adults and have been mostly unsuccessful. We developed and tested administrative data-based algorithms in a population-based cohort of adolescents and young adults with cancer. METHODS: We identified all Ontario adolescents and young adults 15-21 years old diagnosed with leukemia, lymphoma, sarcoma, or testicular cancer between 1992-2012...
July 20, 2017: Medical Care
https://www.readbyqxmd.com/read/28730502/establishment-of-11-linked-x-str-loci-within-1-1-mb-to-assist-with-kinship-testing
#11
James Chun-I Lee, Chun-Yen Lin, Li-Chin Tsai, Yu-Jen Yu, Keng-Hsien Liao, Adrian Linacre, Hsing-Mei Hsieh
This report identifies and characterizes 10 novel short tandem repeat (STR) loci on the human X chromosome, all of which are within a range of 1.1 Mb. These newly characterized loci were developed to aid in kinship assignment when the X chromosome is specifically required. The repeat DNA sequences were identified initially using data in GenBank and are located immediately upstream and downstream from the previously described locus DXS6807. Only those loci with seven or more observed alleles were used for further study resulting in the identification of 10 new loci...
July 20, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28730066/-these-are-not-luxuries-it-is-essential-for-access-to-life-disability-related-out-of-pocket-costs-as-a-driver-of-economic-vulnerability-in-south-africa
#12
Jill Hanass-Hancock, Siphumelele Nene, Nicola Deghaye, Simmi Pillay
BACKGROUND: With the dawn of the new sustainable development goals, we face not only a world that has seen great successes in alleviating poverty but also a world that has left some groups, such as persons with disabilities, behind. Middle-income countries (MICs) are home to a growing number of persons with disabilities. As these countries strive to achieve the new goals, we have ample opportunity to include persons with disabilities in the emerging poverty alleviation strategies. However, a lack of data and research on the linkages between economic vulnerability and disability in MICs hampers our understanding of the factors increasing economic vulnerability in people with disabilities...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28729648/a-haplotype-in-cfh-family-genes-confers-high-risk-of-rare-glomerular-nephropathies
#13
Yin Ding, Weiwei Zhao, Tao Zhang, Hao Qiang, Jianping Lu, Xin Su, Shuzhen Wen, Feng Xu, Mingchao Zhang, Haitao Zhang, Caihong Zeng, Zhihong Liu, Huimei Chen
Despite distinct renal lesions, a series of rare glomerular nephropathies are reportedly mediated by complement overactivation. Genetic variations in complement genes contribute to disease risk, but the relationship of genotype to phenotype has not been straightforward. Here, we screened 11 complement genes from 91 patients with atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy (C3G) and membranoproliferative glomerulonephritis type I (MPGN I), and identified the concomitant presence of three missense variations located within the human complement Factor H (CFH) gene cluster...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729615/deletion-of-the-cela-gene-in-aspergillus-nidulans-triggers-overexpression-of-secondary-metabolite-biosynthetic-genes
#14
Gea Guerriero, Lucia Silvestrini, Sylvain Legay, Frank Maixner, Michael Sulyok, Jean-Francois Hausman, Joseph Strauss
Although much progress has been made in the study of cell wall biosynthetic genes in the model filamentous fungus Aspergillus nidulans, there are still targets awaiting characterization. An example is the gene celA (ANIA_08444) encoding a putative mixed linkage glucan synthase. To characterize the role of celA, we deleted it in A. nidulans, analyzed the phenotype of the mycelium and performed RNA-Seq. The strain shows a very strong phenotype, namely "balloons" along the hyphae and aberrant conidiophores, as well as an altered susceptibility to cell wall drugs...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28728061/qualifying-information-on-deaths-and-serious-injuries-caused-by-road-traffic-in-five-brazilian-capitals-using-record-linkage
#15
Polyana Maria Pimenta Mandacaru, Ana Lucia Andrade, Marli Souza Rocha, Fernanda Pinheiro Aguiar, Maria Sueli M Nogueira, Anne Marielle Girodo, Ana Amélia Galas Pedrosa, Vera Lídia Alves de Oliveira, Marta Maria Malheiros Alves, Lúcia Maria Miana M Paixão, Deborah Carvalho Malta, Marta Maria Alves Silva, Otaliba Libanio de Morais Neto
INTRODUCTION: Road traffic crashes (RTC) are an important public health problem, accounting for 1.2 million deaths per year worldwide. In Brazil, approximately 40,000 deaths caused by RTC occur every year, with different trends in the Federal Units. However, these figures may be even greater if health databases are linked to police records. In addition, the linkage procedure would make it possible to qualify information from the health and police databases, improving the quality of the data regarding underlying cause of death, cause of injury in hospital records, and injury severity...
July 17, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28727023/rapid-communication-high-resolution-quantitative-trait-loci-analysis-identifies-ltbp2-encoding-latent-transforming-growth-factor-beta-binding-protein-2-associated-with-thoracic-vertebrae-number-in-a-large-f2-intercross-between-landrace-and-korean-native-pigs
#16
H-B Park, S-H Han, J-B Lee, I-C Cho
Number of vertebrae is associated with body size and meat productivity in pigs. The aim of this study was to identify QTL and associated positional candidate genes affecting the number of thoracic vertebrae (THO). A genomewide association study was conducted in a large resource population derived from an F intercross between Landrace and Korean native pigs using the Porcine SNP 60K BeadChip and the genomewide complex trait analysis (GCTA) program based on a linear mixed-effects model. A total of 38,385 SNP markers from 1,105 F progeny were analyzed for the THO trait after filtering for quality control...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726979/chronic-disease-registries-trends-and-challenges
#17
Joachim Schüz, Michael Fored
BACKGROUND: This accompanying editorial is an introduction to the focus theme of "chronic disease registries - trends and challenges". METHODS: A call for papers was announced on the website of Methods of Information in Medicine in April 2016 with submission deadline in September 2016. A peer review process was established to select the papers for the focus theme, managed by two guest editors. RESULTS: Three papers were selected to be included in the focus theme...
July 19, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28726280/an-efficient-study-design-to-test-parent-of-origin-effects-in-family-trios
#18
Xiaobo Yu, Gao Chen, Rui Feng
Increasing evidence has shown that genes may cause prenatal, neonatal, and pediatric diseases depending on their parental origins. Statistical models that incorporate parent-of-origin effects (POEs) can improve the power of detecting disease-associated genes and help explain the missing heritability of diseases. In many studies, children have been sequenced for genome-wide association testing. But it may become unaffordable to sequence their parents and evaluate POEs. Motivated by the reality, we proposed a budget-friendly study design of sequencing children and only genotyping their parents through single nucleotide polymorphism array...
July 20, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/28725879/using-closure-tables-to-enable-cross-querying-of-ontologies-in-database-driven-applications
#19
Daniel R Harris, Darren W Henderson, Jeffery C Talbert
We demonstrate that closure tables are an effective data structure for developing database-driven applications that query biomedical ontologies and that require cross-querying between multiple ontologies. A closure table stores all available paths within a tree, even those without a direct parent-child relationship; additionally, a node can have multiple ancestors which gives the foundation for supporting linkages between controlled ontologies. We augment the meta-data structure of the ICD9 and ICD10 ontologies included in i2b2, an open source query tool for identifying patient cohorts, to utilize a closure table...
February 2017: IEEE-EMBS International Conference on Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28725622/authentication-of-piper-betle-l-folium-and-quantification-of-their-antifungal-activity
#20
I Made Agus Gelgel Wirasuta, I Gusti Ayu Made Srinadi, Ida Bagus Gede Dwidasmara, Ni Luh Putu Putri Ardiyanti, I Gusti Ayu Arya Trisnadewi, Ni Luh Putu Vidya Paramita
The TLC profiles of intra- and inter-day precision for Piper betle L. (PBL) folium methanol extract was studied for their peak marker recognition and identification. The Numerical chromatographic parameters (NCPs) of the peak markers, the hierarchical clustering analysis (HCA) and the principal component analysis (PCA) were applied to authenticate the PBL. folium extract from other Piper species folium extract and to ensure the antifungal activity quality of the PBL essential oil. The spotted extract was developed with the mobile phase of toluene: ethyl acetate; 93:7, (v/v)...
July 2017: Journal of Traditional and Complementary Medicine
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