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https://www.readbyqxmd.com/read/28431957/genetic-study-of-kir-and-hla-ligands-in-235-individuals-from-northeastern-thailand
#1
Suwit Chaisri, Chanvit Leelayuwat, Amornrat Romphruk
The diversity of 17 KIR and HLA ligands (HLA-C1, C2, Bw4, A11) were investigated in two hundred and thirty-five unrelated healthy donors in Northeastern Thais (NETs) by the polymerase chain reaction with sequence-specific primer (PCR-SSP) method. The Hardy-Weinberg Equilibrium (HWE) was used to verify genotyping method for dimorphic KIR and HLA. They were in HWE (p>0.05). KIR and HLA ligands frequencies, genotypes, haplotypes and linkage disequilibrium (LD) were presented. The genetic data are available in allele Frequencies Net Database...
April 18, 2017: Human Immunology
https://www.readbyqxmd.com/read/28430851/accuracy-of-offspring-reported-parental-hip-fractures-a-novel-population-based-parent-offspring-record-linkage-study
#2
Lisa M Lix, William D Leslie, Shuman Yang, Lin Yan, Randy Walld, Suzanne N Morin, Sumit R Majumdar, Leslie L Roos
The objective of this study was to test the validity of offspring-reported parental hip fracture in a unique bone mineral density (BMD) registry linked to administrative databases spanning 4 decades. Population-based data were from Manitoba, Canada, and included hospital abstracts, health insurance registrations, and the provincewide BMD registry. The cohort included individuals aged ≥40 years with BMD tests and self-reports of parental hip fracture between 2006 and 2014. Population registry data for 1966-2014 were used to link offspring with their parents, and hospital records were used to ascertain parental fractures...
April 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28430632/association-analysis-of-apo-gene-polymorphisms-with-ischemic-stroke-risk-a-case-control-study-in-a-chinese-han-population
#3
Rongjun Xiao, Shuaiqi Sun, Jiayi Zhang, Yongri Ouyang, Ning Zhang, Min Yang, Tianbo Jin, Ying Xia
This study aimed to assess the association of APO gene polymorphisms and ischemic stroke risk in a Chinese Han population. In this case-control study, we geno-typed 14 single nucleotide polymorphisms (SNPs) in 3 APO genes in 488 cases and 503 controls using Sequenom Mass-ARRAY technology and evaluated their association with ischemic stroke using the χ2 and genetic model analysis. In the allelic model analysis, we determined three SNPs were significantly associated with ischemic stroke: rs693 with a p value of 0...
February 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28428750/applying-an-archetype-based-approach-to-electroencephalography-event-related-potential-experiments-in-the-eegbase-resource
#4
Václav Papež, Roman Mouček
PURPOSE: The purpose of this study is to investigate the feasibility of applying openEHR (an archetype-based approach for electronic health records representation) to modeling data stored in EEGBase, a portal for experimental electroencephalography/event-related potential (EEG/ERP) data management. The study evaluates re-usage of existing openEHR archetypes and proposes a set of new archetypes together with the openEHR templates covering the domain. The main goals of the study are to (i) link existing EEGBase data/metadata and openEHR archetype structures and (ii) propose a new openEHR archetype set describing the EEG/ERP domain since this set of archetypes currently does not exist in public repositories...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28427838/stratification-strategy-for-evaluating-the-influence-of-diabetes-complication-severity-index-on-the-risk-of-hospitalization-a-record-linkage-data-in-western-australia
#5
Ninh Thi Ha, Mark Harris, Suzanne Robinson, David Preen, Rachael Moorin
OBJECTIVE: This study aimed to develop a risk stratification strategy for evaluating the relationship between complications of diabetes and the risk of diabetic-related hospitalization to accurately classify diabetes severity. METHODS: The study used administrative health records for 40,624 individuals with diabetes aged ≥18years in Western Australian. The adapted Diabetes Complication Severity Index (DCSI), socio-demographic and clinical characteristics were used in random effects negative binomial and threshold effect models to determine the optimal stratification strategy for diabetes severity based on the homogeneity of the risk of hospitalization in response to variation of the DCSI...
April 5, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28427711/maternal-and-perinatal-characteristics-of-infants-who-later-in-life-developed-multiple-sclerosis-record-linkage-study
#6
Alexander Goldacre, Julia Pakpoor, Michael Goldacre
BACKGROUND: Pre-natal and early life factors may have a role in multiple sclerosis (MS) pathogenesis in some people. However, the reporting of any influence of maternal and perinatal factors on MS risk has been limited. We aimed to study maternal and perinatal characteristics of babies who went on to develop MS. METHODS: Data were analysed from the historical Oxford Record Linkage Study dataset 1970-1989, which incorporated a specialised maternity dataset with record linkage between mother and baby, covering a population of 850,000...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28427468/learning-from-biomedical-linked-data-to-suggest-valid-pharmacogenes
#7
Kevin Dalleau, Yassine Marzougui, Sébastien Da Silva, Patrice Ringot, Ndeye Coumba Ndiaye, Adrien Coulet
BACKGROUND: A standard task in pharmacogenomics research is identifying genes that may be involved in drug response variability, i.e., pharmacogenes. Because genomic experiments tended to generate many false positives, computational approaches based on the use of background knowledge have been proposed. Until now, only molecular networks or the biomedical literature were used, whereas many other resources are available. METHOD: We propose here to consume a diverse and larger set of resources using linked data related either to genes, drugs or diseases...
April 20, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28427366/network-analysis-of-global-tobacco-control-collaboration-data-from-the-world-conference-on-tobacco-or-health-wctoh
#8
Scott J Leischow, Janet Okamoto, Scott McIntosh, Deborah J Ossip, Harry A Lando
BACKGROUND: The World Conference on Tobacco or Health (WCTOH) is held every three years to foster communication and collaboration on global tobacco control. Very little is known about the nature of interactions between WCTOH attendees and their linkages to tobacco control organizations, so knowing this information could help improve tobacco control efforts. METHODS: At the 2015 WCTOH, we implemented an online survey to assess barriers to global tobacco control activities, which information sources they use for tobacco control information, and with whom they interact regarding tobacco control...
April 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28427323/detection-of-qtl-for-traits-related-to-adaptation-to-sub-optimal-climatic-conditions-in-chickens
#9
Ching-Yi Lien, Michèle Tixier-Boichard, Shih-Wen Wu, Woei-Fuh Wang, Chen Siang Ng, Chih-Feng Chen
BACKGROUND: Growth traits can be used as indicators of adaptation to sub-optimal conditions. The current study aimed at identifying quantitative trait loci (QTL) that control performance under variable temperature conditions in chickens. METHODS: An F2 population was produced by crossing the Taiwan Country chicken L2 line (selected for body weight, comb area, and egg production) with an experimental line of Rhode Island Red layer R- (selected for low residual feed consumption)...
April 20, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28426359/reductions-in-hard-drug-use-among-homeless-youth-receiving-a-strength-based-outreach-intervention-comparing-the-long-term-effects-of-shelter-linkage-versus-drop-in-center-linkage
#10
Xiamei Guo, Natasha Slesnick
OBJECTIVES: The current study sought to test hard drug use outcomes for youth receiving a strengths-based outreach and advocacy intervention that linked youth to either a shelter or a drop-in center. METHODS: Homeless youth (14-24 years old) were engaged by research assistants (RAs) at soup kitchens, parks, libraries, and other locations that homeless youth were known to frequent. Youth were randomly assigned to receive six months of advocacy that focused on linking youth to a drop-in center (n = 40) or to a crisis shelter (n = 39)...
June 7, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28425728/parent-teacher-child-child-relationships-and-engagement-at-school-entry-mediating-interactive-and-transactional-associations-across-contexts
#11
Melissa Castle Heatly, Elizabeth Votruba-Drzal
Early school engagement patterns set the stage for short- and long-term academic behaviors and progress, and low engagement at school entry can give rise to dysfunctional school behavior and underachievement in later years. Relationships with parents and teachers provide a foundation upon which children develop the skills and behaviors that are critical for engagement in early elementary school. However, the cross-contextual and transactional processes by which these relationships are associated with engagement in early elementary school remain unclear...
April 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28425640/profiling-of-the-silica-induced-molecular-events-in-lung-epithelial-cells-using-the-rna-seq-approach
#12
Judy Y W Chan, Joseph C C Tsui, Patrick T W Law, Winnie K W So, Doris Y P Leung, Michael M K Sham, Stephen K W Tsui, Carmen W H Chan
Silicosis is a prolonged, irreversible and incurable occupational disease, and there is a significant number of newly diagnosed cases every year in Hong Kong. Due to the long latency of the disease, the diagnosis can be missed until detailed clinical examination at a later stage. For a better control of this deadly disease, detailing the pro-inflammatory and fibrotic events in the macrophage would be instrumental in understanding the pathogenesis of the disease and essential for the significant biomarkers discovery...
April 20, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28424795/an-open-label-cluster-randomised-trial-to-evaluate-the-effectiveness-of-a-counselling-intervention-on-linkage-to-care-among-hiv-infected-patients-in-uganda-study-design
#13
Eugene Ruzagira, Kathy Baisley, Anatoli Kamali, Heiner Grosskurth
INTRODUCTION: Home-based HIV counselling & testing (HBHCT) is highly acceptable and has the potential to increase HIV testing uptake in sub-Saharan Africa. However, data are lacking on strategies that can effectively link HIV-positive individuals identified through HBHCT to care. This trial was designed to assess the effectiveness of two brief home-based counselling sessions on linkage to care, provided subsequent to referral for care among HIV-positive patients identified through HBHCT in a rural community in Masaka district, Uganda...
March 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28423775/combining-different-privacy-preserving-record-linkage-methods-for-hospital-admission-data
#14
Jürgen Stausberg, Andreas Waldenburger, Christian Borgs, Rainer Schnell
Record linkage (RL) is the process of identifying pairs of records that correspond to the same entity, for example the same patient. The basic approach assigns to each pair of records a similarity weight, and then determines a certain threshold, above which the two records are considered to be a match. Three different RL methods were applied under privacy-preserving conditions on hospital admission data: deterministic RL (DRL), probabilistic RL (PRL), and Bloom filters. The patient characteristics like names were one-way encrypted (DRL, PRL) or transformed to a cryptographic longterm key (Bloom filters)...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423774/the-pearl-data-warehouse-initial-challenges-faced-with-semantic-and-syntactic-interoperability
#15
Samhar Mahmoud, Andy Boyd, Vasa Curcin, Richard Bache, Asad Ali, Simon Miles, Adel Taweel, Brendan Delaney, John Macleod
Data about patients are available from diverse sources, including those routinely collected as individuals interact with service providers, and those provided directly by individuals through surveys. Linking these data can lead to a more complete picture about the individual, to inform either care decision making or research investigations. However, post-linkage, differences in data recording systems and formats present barriers to achieving these aims. This paper describes an approach to combine linked GP records with study observations, and reports initial challenges related to semantic and syntactic interoperability issues...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423058/accurate-phenotyping-reconciling-approaches-through-bayesian-model-averaging
#16
Carla Chia-Ming Chen, Jonathan Macgregor Keith, Kerrie Lee Mengersen
Genetic research into complex diseases is frequently hindered by a lack of clear biomarkers for phenotype ascertainment. Phenotypes for such diseases are often identified on the basis of clinically defined criteria; however such criteria may not be suitable for understanding the genetic composition of the diseases. Various statistical approaches have been proposed for phenotype definition; however our previous studies have shown that differences in phenotypes estimated using different approaches have substantial impact on subsequent analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28422318/computational-analysis-of-breast-cancer-gwas-loci-identifies-the-putative-deleterious-effect-of-stxbp4-and-znf404-gene-variants
#17
Tariq Ahmad Masoodi, Babajan Banaganapalli, Venkatesh Vaidyanathan, Venkateswar Rao Talluri, Noor Ahmad Shaik
The genome-wide association studies (GWAS) have enabled us in identifying different breast cancer susceptibility loci. However, majority of these are non-coding variants with no annotated biological function. We investigated such 78 noncoding genome wide associated SNPs of breast cancer and further expanded the list to 2162 variants with strong linkage-disequilibrium (LD, r2 ≥0.8). Using multiple publically available algorithms such as CADD, GWAVA and FATHAMM, we classified all these variants in to deleterious, damaging or benign categories...
April 19, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28420356/an-assessment-of-the-hiv-tb-knowledge-and-skills-of-home-based-carers-working-in-the-north-west-province-in-south-africa-a-cross-sectional-study
#18
Justin G Engelbrecht, Mabjala R Letsoalo, Admire C Chirowodza
BACKGROUND: Home-based carers (HBCs) play a critical role in ensuring the success of the primary health care re-engineering strategy in South Africa. Their role includes ensuring improved access to and delivery of primary health care at the household level, and better co-ordination and improved linkages between community and health facilities for HIV/TB services. The objective of this study was to assess the knowledge, skills, challenges and training needs of HBCs involved in HIV/TB care in one sub-district in the North-West province of South Africa...
April 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28419381/enhancing-faba-bean-vicia-faba-l-genome-resources
#19
James W Cooper, Michael H Wilson, Martijn F L Derks, Sandra Smit, Karl J Kunert, Christopher Cullis, Christine H Foyer
Grain legume improvement is currently impeded by a lack of genomic resources. The paucity of genome information for faba bean can be attributed to the intrinsic difficulties of assembling/annotating its giant (~13 Gb) genome. In order to address this challenge, RNA-sequencing analysis was performed on faba bean (cv. Wizard) leaves. Read alignment to the faba bean reference transcriptome identified 16 300 high quality unigenes. In addition, Illumina paired-end sequencing was used to establish a baseline for genomic information assembly...
April 17, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28418721/practical-applications-of-generalizability-theory-for-designing-evaluating-and-improving-psychological-assessments
#20
Walter P Vispoel, Carrie A Morris, Murat Kilinc
In this article, we illustrate how generalizability theory (G-theory) can extend traditional assessment methods for designing, improving, and evaluating results from both objectively and subjectively scored measures of individual differences. Our illustrations include quantification of multiple sources of measurement error, derivation of unique indexes of consistency for norm- and criterion-referenced interpretations of scores, estimation of score consistency when changing a measurement procedure, and disattenuation of correlation coefficients for measurement error...
April 18, 2017: Journal of Personality Assessment
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