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Pulmonary Paracoccidioidomycosis

Denise Turini Gonzales Marioto, Ana Carolina Navarro Dos Santos Ferraro, Fábio Goulart de Andrade, Marília Barros Oliveira, Eiko Nakagawa Itano, Silvana Petrofeza, Emerson José Venancio
MicroRNAs (miRNAs) are small single stranded RNA sequences involved in post-transcriptional regulation of different biological and physiological processes. Paracoccidioidomycosis (PCM) is an infection caused by Paracoccidioides brasiliensis, and it is a major cause of mortality due to systemic mycoses in Brazil. To date, there have been few reports on the role of miRNAs in the immune response against fungi, especially PCM. The objective of this study was to evaluate the differential expression of miRNAs related to the inflammatory response associated with pulmonary infection by P...
January 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Marcelo V Radisic, Laura Linares, Javier Afeltra, Natalia Pujato, Roxana G Vitale, Martin Bravo, Ana C Dotta, Domingo H Casadei
Paracoccidioides brasiliensis is the cause of paracoccidioidomycosis, one of the most important systemic mycoses in Latin America. Human disease has been observed in a limited geographic and ecological niche, and it is attributed to exposure to the fungus in soil. Most primary infections are subclinical, as the infection is contained by the host mainly through cell-mediated immune response. However, as the fungus has the ability to survive in a dormant state for long periods, an impairment of the immune response may lead to reactivation and clinical disease...
December 31, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Valdes Roberto Bollela, Fernanda Guioti Puga, Maria Janete Moya, Mauro Andrea, Maria de Lourdes Viude Oliveira
The aim of this retrospective study was to review all the notified cases of multidrug-resistant tuberculosis (MDR-TB) in São Paulo State (Brazil), as well as to describe and discuss the clinical, microbiological and radiologic aspects in a single reference center, within the same state, from 2000 to 2012. There were 1,097 notifications of MDR-TB in São Paulo State over this period, 70% affecting men aged on average 38 years (10-77). There was a significant fall in the MDR-TB mortality rate from 30% to 8% (2000-2003 versus 2009-2012)...
November 3, 2016: Revista do Instituto de Medicina Tropical de São Paulo
Sérgio Monteiro de Almeida, Thiago Henrique Roza
The immune reconstitution inflammatory syndrome (IRIS) is a deregulated inflammatory response to invading microorganisms. It is manifested when there is an abrupt change in host immunity from an anti-inflammatory and immunosuppressive state to a pro-inflammatory state as a result of rapid depletion or removal of factors that promote immune suppression or inhibition of inflammation. The aim of this paper is to discuss and re-interpret the possibility of association of paracoccidioidomycosis (PCM) with IRIS in the central nervous system (CNS) in a case from Brazil published by Silva-Vergara ML...
October 7, 2016: Mycopathologia
Juan David Puerta-Arias, Paula Andrea Pino-Tamayo, Julián Camilo Arango, Ángel González
Chronic stages of paracoccidioidomycosis (PCM) are characterized by granulomatous lesions which promote the development of pulmonary fibrosis leading to the loss of respiratory function in 50% of patients; in addition, it has been observed that neutrophils predominate during these chronic stages of P. brasiliensis infection. The goal of this study was to evaluate the role of the neutrophil during the chronic stages of experimental pulmonary PCM and during the fibrosis development and tissue repair using a monoclonal specific to this phagocytic cell...
2016: PloS One
Paula Andrea Pino-Tamayo, Juan David Puerta-Arias, Damaris Lopera, Martha Eugenia Urán-Jiménez, Ángel González
Neutrophils predominate during the acute phase of the Paracoccidioides brasiliensis infection. Herein, we determined the role of the neutrophil during the early stages of experimental pulmonary paracoccidioidomycosis using a monoclonal antibody (mAb) specific for neutrophils. Male BALB/c mice were inoculated intranasally with 1.5 × 10(6) or 2 × 10(6) P. brasiliensis yeast cells. The mAb was administered 24 h before infection, followed by doses every 48 h until mice were sacrificed. Survival time was evaluated and mice were sacrificed at 48 h and 96 h after inoculation to assess cellularity, fungal load, cytokine/chemokine levels, and histopathological analysis...
2016: Mediators of Inflammation
Ederson Valei Lopes de Oliveira, Margarete Teresa Gottardo de Almeida, Aline Turatti, Ciro Martins Gomes, Ana Maria Roselino
Distinct cases of Paracoccidioidomycosis and Cryptococcosis with atypical and localized skin manifestation on the upper limbs of two elderly patients are reported. In the 2nd one, he presented asymptomatic pulmonary cancer; the blood tests for fungal infection were negative, and the etiologic agents were seen in skin biopsy samples. This report emphasizes the importance of the differential diagnosis of infectious diseases in elderly patients.
April 2016: Anais Brasileiros de Dermatologia
Priscila Marques de Macedo, Rodrigo Almeida-Paes, Mauro de Medeiros Muniz, Manoel Marques Evangelista Oliveira, Rosely Maria Zancopé-Oliveira, Regina Lana Braga Costa, Antonio Carlos Francesconi do Valle
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by pathogenic dimorphic fungi of the Paracoccidioides brasiliensis complex. It is the most important systemic mycosis in Latin America, mainly in Brazil. Despite its severity and high mortality rates, it is considered a neglected disease. Species within the genus Paracoccidioides present genetics and morphological variations with probable clinical, diagnostic and therapeutic consequences. In fact, there are a very small number of detailed case reports with molecular identification of these fungal agents...
October 2016: Mycopathologia
Rodolfo Mendes Queiroz, Michela Prestes Gomes, Marcus Vinicius Nascimento Valentin
No abstract text is available yet for this article.
January 2016: Radiologia Brasileira
Renata Buccheri, Zarifa Khoury, Luis Carlos Barradas Barata, Gil Benard
UNLABELLED: Several aspects of the natural history of paracoccidioidomycosis are still poorly understood. Different from the most prevalent, chronic form of the disease, the acute form represents a continuum from the initial respiratory infection to the full-blown disease, thus providing an opportunity to elucidate the pathogenesis of the early phase of this mycosis. We describe, for the first time, two patients with a single time point exposure to Paracoccidioides spp., for whom we were able to determine the time lapsed between exposure to the fungus Paracoccidioides spp...
June 2016: Mycopathologia
Lucas Giansante Abud, Rodolfo Mendes Queiroz, Thiago Giansante Abud
No abstract text is available yet for this article.
November 2015: Revista da Sociedade Brasileira de Medicina Tropical
Laura R R Ribeiro, Flávio V Loures, Eliseu F de Araújo, Cláudia Feriotti, Tânia A Costa, Carlos Henrique Serezani, Sonia Jancar, Vera L G Calich
Cysteinyl leukotrienes (CysLTs) and lipoxins (LXs) are lipid mediators that control inflammation, with the former inducing and the latter inhibiting this process. Because the role played by these mediators in paracoccidioidomycosis was not investigated, we aimed to characterize the role of CysLT in the pulmonary infection developed by resistant (A/J) and susceptible (B10.A) mice. 48 h after infection, elevated levels of pulmonary LTC4 and LXA4 were produced by both mouse strains, but higher levels were found in the lungs of susceptible mice...
2015: Mediators of Inflammation
Silvia B Bazan, Tania A Costa, Eliseu Frank de Araújo, Claudia Feriotti, Flávio V Loures, Fernando D Pretel, Vera L G Calich
Paracoccidioidomycosis (PCM), is a pulmonary fungal disease whose severity depends on the adequate development of T cell immunity. Although regulatory T (Treg) cells were shown to control immunity against PCM, deleterious or protective effects were described in different experimental settings. To clarify the function of Treg cells in pulmonary PCM, loss-and gain-of-function approaches were performed with Foxp3GFP knock-in mice and immunodeficient Rag1-/- mice, respectively, which were intratracheally infected with 106 yeast cells...
2015: PLoS Neglected Tropical Diseases
Maria Aparecida Shikanai-Yasuda
Considered to be an emerging endemic mycosis in Latin America, paracoccidioidomycosis is characterized by a chronic course and involvement of multiple organs in immunocompromised hosts. Infection sequelae are mainly related to pulmonary and adrenal insufficiency. The host-parasite interaction results in different expressions of the immune response depending on parasite pathogenicity, fungal load and genetic characteristics of the host. A few controlled and case series reports have shown that azoles and fast-acting sulfa derivatives are useful treatment alternatives in milder forms of the disease...
September 2015: Revista do Instituto de Medicina Tropical de São Paulo
Mariana Guimarães Coelho, Cecília Bittencourt Severo, Flávio de Mattos Oliveira, Bruno Hochhegger, Luiz Carlos Severo
Sarcoidosis is a multisystem disorder that is characterized by noncaseous epithelioid cell granulomas, which may affect almost any organ. Thoracic involvement is common and accounts for most of the morbidity and mortality associated with this disease. The diagnosis is based on exhaustive exclusion of differential diagnoses, particularly granulomatous infections. We report data on eight patients with paracoccidioidomycosis mimicking sarcoidosis. Five patients presented with a chronic pulmonary type infection and three had a disseminated form after immunosuppressive treatment...
February 2016: Mycopathologia
Miriam Menna Barreto, Edson Marchiori, Andrea de Brito, Dante Luiz Escuissato, Bruno Hochhegger, Arthur Soares Souza, Rosana Souza Rodrigues
OBJECTIVE: The purpose of this study was to identify morphological characteristics of the reversed halo sign (RHS) on chest CT in patients with pulmonary paracoccidioidomycosis (PCM) that may aid the diagnosis of this fungal disease. METHODS: We retrospectively reviewed chest CT images from 23 patients with proven pulmonary PCM who demonstrated the RHS. Two chest radiologists analysed the morphological characteristics of the lesions and reached decisions by consensus...
2015: British Journal of Radiology
Priscila Zacarias de Azevedo, Tatiane Fernanda Sylvestre, Ricardo de Souza Cavalcante, Lídia Raquel de Carvalho, Daniela Vanessa Moris, Maria Luiza Cotrim Sartor de Oliveira, Rinaldo Poncio Mendes
The diagnosis of chronic pulmonary aspergillosis (CPA) depends on the radiologic image and the identification of specific antibodies. The present study aimed to evaluate accuracy parameters of enzyme-linked immunosorbent assay (ELISA) and of the determination of serum galactomannan level in the diagnosis of patients with CPA, comparing these results with the double agar gel immunodiffusion (DID) test. In addition, the prevalence of cross-reactivity and the serological progression after treatment were evaluated by comparing DID and ELISA...
2015: PloS One
Damaris Elena Lopera, Tonny Williams Naranjo, José Miguel Hidalgo, Laura Echeverri, Jairo Hernando Patiño, Ángela Restrepo Moreno, Henrique Leonel Lenzi, Luz Elena Cano
BACKGROUND: Pentoxifylline (PTX) is a methylxanthine compound with immunomodulatory and antifibrotic properties. The simultaneous use of PTX and antifungal therapy (itraconazole) has previously been evaluated in an experimental model of pulmonary paracoccidioidomycosis (PCM), a systemic fungal disease caused by the fungus Paracoccidioides brasiliensis (Pb) and characterized by chronic inflammation and lung fibrosis that appears even after a successful course of antifungal therapy. The results revealed prompt and statistically significant reductions in inflammation and fibrosis when compared to itraconazole alone...
2015: Fibrogenesis & Tissue Repair
Patrícia Fernanda Zambuzzi-Carvalho, Amanda Gregorim Fernandes, Marize Campos Valadares, Patrícia de Mello Tavares, Joshua D Nosanchuk, Célia Maria de Almeida Soares, Maristela Pereira
Paracoccidioidomycosis (PCM) is the most prevalent mycosis in Latin America and is caused by a group of fungi within the Paracoccidioides genus. The disease may present clinical and pathological manifestations ranging from asymptomatic pneumonia pulmonary lesions, to disseminated forms involving multiple organs. Sulfonamides were the first drugs used to treat PCM and are still used against this fungal infection. Sulfa drugs are competitive antagonists of ρ-aminobenzoic acid (PABA), a reaction catalyzed by dihydropteroate synthase (DHPS)...
June 2015: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Francisco Valtenor Araújo Lima Júnior, Leonor Garbin Savarese, Lucas Moretti Monsignore, Roberto Martinez, Marcello Henrique Nogueira-Barbosa
OBJECTIVE: To evaluate musculoskeletal involvement in paracoccidioidomycosis at computed tomography. MATERIALS AND METHODS: Development of a retrospective study based on a review of radiologic and pathologic reports in the institution database. Patients with histopathologically confirmed musculoskeletal paracoccidioidomycosis and submitted to computed tomography were included in the present study. The imaging findings were consensually described by two radiologists...
January 2015: Radiologia Brasileira
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