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Transient ischemic dilation ratio

Promporn Suksaranjit, Christopher J McGann, Nazem Akoum, Joseph Biskupiak, Gregory J Stoddard, Eugene G Kholmovski, Leenhapong Navaravong, Allen Rassa, Erik Bieging, Lowell Chang, Imran Haider, Nassir F Marrouche, Brent D Wilson
Left ventricular (LV) scar identified by late gadolinium enhanced (LGE) cardiac magnetic resonance (CMR) is associated with adverse outcomes in coronary artery disease and cardiomyopathies. We sought to determine the prognostic significance of LV-LGE in atrial fibrillation (AF). We studied 778 consecutive patients referred for radiofrequency ablation of AF who underwent CMR. Patients with coronary artery disease, previous myocardial infarction, or hypertrophic or dilated cardiomyopathy were excluded. The end points of interest were major adverse cardiac and cerebrovascular events (MACCE), defined as a composite of cardiovascular death, myocardial infarction, and ischemic stroke/transient ischemic attack...
October 1, 2016: American Journal of Cardiology
Zenith A Jameria, Mouhamad Abdallah, Alok Dwivedi, Erica Washburn, Naseer Khan, Mahyar Khaleghi, Nischelle Kalakota, Myron C Gerson
BACKGROUND: Transient ischemic dilation (TID) of the left ventricle (LV) has not been validated as a marker of extensive coronary artery disease (CAD) for studies using a cadmium-zinc-telluride (CZT) camera with upright imaging. METHODS: TID ratios were obtained from upright stress and rest images on a CZT camera. Separate cut-off values were determined for exercise and for regadenoson stress. The cutoffs were then applied to 28 patients with extensive CAD and 101 patients without extensive CAD...
June 16, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Peter M Okin, Hooman Kamel, Sverre E Kjeldsen, Richard B Devereux
BACKGROUND: Recent findings in population-based studies suggest that abnormal P wave terminal force in lead V1 (PTFV1), a marker of left atrial abnormalities such as fibrosis, dilatation and elevated filling pressures, is associated with incident ischemic stroke, even in the absence of atrial fibrillation. However, whether PTFV1 predicts incident stroke in hypertensive patients during blood pressure lowering has not been examined. METHODS: Risk of incident stroke was examined in relation to abnormal PTFV1 on a baseline ECG in 7778 hypertensive patients with ECG left ventricular hypertrophy, no history of atrial fibrillation, in sinus rhythm on their baseline ECG with no incident atrial fibrillation during follow-up, who were randomly assigned to losartan-based or atenolol-based treatment...
September 2016: Journal of Hypertension
Haruki Tanaka, Teruyuki Takahashi, Nami Kozono, Yoshiki Tanakamaru, Norihiko Ohashi, Yuji Yasunobu, Koichi Tanaka, Takenori Okada, Shunichi Kaseda, Toshio Nakanishi, Yasuki Kihara
Although fractional flow reserve (FFR) and myocardial perfusion imaging (MPI) findings fundamentally differ, several cohort studies have revealed that these findings correlate. Here, we investigated whether flow-limiting FFR could be predicted from adenosine stress thallium-201 MPI with single-photon emission computed tomography (SPECT) findings derived from 84 consecutive, prospectively identified patients with stable coronary artery disease and 212 diseased vessels. Among them, FFR was measured in 136 diseased vessels (64%)...
May 1, 2016: American Journal of Cardiology
Davis Lester, Stephanie El-Hajj, Ayman A Farag, Pradeep Bhambhvani, Lindsey Tauxe, Jaekyeong Heo, Ami E Iskandrian, Fadi G Hage
BACKGROUND: Transient ischemic dilation (TID) of the left ventricle seen on myocardial perfusion imaging (MPI) is sometimes used as a marker of severe coronary artery disease. The prognostic value of TID obtained using regadenoson, a selective adenosine A2A receptor agonist, as a stress agent for MPI has not been studied. METHODS: TID ratio was measured using an automated software program on consecutive patients with normal and abnormal perfusion pattern on regadenoson MPI at a single institution...
October 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Chia-Ju Liu, Yen-Wen Wu, Kuan-Yin Ko, Yi-Chieh Chen, Mei-Fang Cheng, Ruoh-Fang Yen, Kai-Yuan Tzen
PURPOSE: Myocardial perfusion imaging (MPI) using gated single-photon emission tomography (gSPECT) may underestimate the severity of coronary artery disease (CAD). This study aimed to evaluate the significance of combined parameters derived from gSPECT, as well as treadmill stress test parameters, in the detection of severe CAD. METHODS: A total of 211 consecutive patients referred for exercise MPI between June 2011 and June 2013 (who received invasive coronary angiography within six months after MPI) were retrospectively reviewed...
2015: PloS One
Maryam Chavoshi, Armaghan Fard-Esfahani, Babak Fallahi, Alireza Emami-Ardekani, Davood Beiki, Arman Hassanzadeh-Rad, Mohammad Eftekhari
OBJECTIVES: Coronary artery disease is the leading cause of mortality worldwide. The goal of this study is to determine the prognostic value of semiquantitative parameters of electrocardiogram-gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in a large Middle Eastern (Iranian) population. MATERIALS AND METHODS: This study was a prospective study including all patients referred to our center for myocardial perfusion scan...
July 2015: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Feng-Di Liu, Rong Zhao, Shuo Wang, Wen-Ting Li, Xiao-Xiao Tao, Ting Sun, Xiao-Lei Shen, Jian-Ren Liu
BACKGROUND: Here we report a rare case of repeated transient Wallenberg's syndrome and discuss its mechanism. METHODS: Case report and literature review. RESULTS: A 57-year-old man was admitted for 1.5-month repeated transient Wallenberg's syndrome, including right-sided Horner's syndrome, lower limb weakness, and paresthesia on the right side of the body and face. His symptom appeared mostly during physical activity. Symptoms occurred nearly everyday and lasted from 5 minutes to 30 minutes...
August 2015: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Mamoru Murakami, Taketo Hatano, Akinori Miyakoshi, Daisuke Arai, Susumu Yamaguchi, Eiji Ogino, Ryo Ohtani, Tetsuya Tsukahara
BACKGROUND AND PURPOSE: We assessed whether intentional undersized dilatation of targeted lesions during carotid artery stenting (CAS) carried a higher risk of in-stent restenosis (ISR) and correlation to subsequent ischemic stroke in qualifying arteries in the follow-up period. METHODS: Consecutive patients undergoing CAS between April 2003 and May 2010 were retrospectively reviewed. The use of a filter device as a distal embolic protection device (EPD) was first approved by Japanese governmental health insurance in April 2008; previously, transient balloon occlusion was used off-label...
2015: British Journal of Neurosurgery
Yasmeen Golzar, Adebayo Olusanya, Nadith Pe, Sumeet G Dua, Jaafer Golzar, Claudia Gidea, Rami Doukky
BACKGROUND: The critical threshold and clinical significance of transient ischemic dilation (TID) for regadenoson, single-isotope (99m)Tc SPECT myocardial perfusion imaging (MPI) are not defined. METHODS: From 100 patients with low likelihood of CAD, we derived the abnormal TID threshold (mean + 2 SD). We validated the threshold in a cohort of 547 patients who received one-day, rest/regadenoson-stress, (99m)Tc-tetrofosmin SPECT-MPI followed by coronary angiography within 6 months...
June 2015: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Paulo W Pires, Saavia S Girgla, Guillermo Moreno, Jonathon L McClain, Anne M Dorrance
Hypertension causes vascular inflammation evidenced by an increase in perivascular macrophages and proinflammatory cytokines in the arterial wall. Perivascular macrophage depletion reduced tumor necrosis factor (TNF)-α expression in cerebral arteries of hypertensive rats and attenuated inward remodeling, suggesting that TNF-α might play a role in the remodeling process. We hypothesized that TNF-α inhibition would improve middle cerebral artery (MCA) structure and reduce damage after cerebral ischemia in hypertensive rats...
September 1, 2014: American Journal of Physiology. Heart and Circulatory Physiology
Asim Aldhilan, Ghulam M S Syed, Ihab Suleiman, M Al Zaibag, Henry Fielding
OBJECTIVE: A high transient ischemic dilatation ratio (TID) for the left ventricle (LV) from a gated myocardial perfusion imaging (G-MPI) study is widely believed to be associated with significant coronary artery disease (CAD). We have investigated the relationship between TID and CAD for our male Saudi Arabian patient population. METHODS: In this retrospective study, all male Saudi Arabian patients who underwent a two-day G-MPI study using Tc99m MIBI during the year 2011 having a TID ⩾ 1...
January 2014: Journal of the Saudi Heart Association
Mario Petretta, Wanda Acampa, Stefania Daniele, Maria Piera Petretta, Monica Plaitano, Alberto Cuocolo
BACKGROUND: We prospectively evaluated the incremental prognostic value of transient ischemic dilation (TID) in patients with type 2 diabetes mellitus during long-term follow-up and estimated cardiac death and nonfatal myocardial infarction (MI) using traditional approaches of prognostication to more recent methods. METHODS AND RESULTS: A total of 672 consecutive diabetic patients with available rest and stress gated myocardial perfusion single-photon emission computed tomographic data were enrolled...
November 2013: Circulation. Cardiovascular Imaging
Rami Doukky, Nathan Frogge, Yohannes A Bayissa, Gautam Balakrishnan, Jacob M Skelton, Kara Confer, Kalindi Parikh, Russell F Kelly
BACKGROUND: The prognostic implications of transient ischemic dilatation (TID) of the left ventricle with otherwise normal single-photon emission computed tomography myocardial perfusion imaging (MPI) remain controversial. Whether this finding may have prognostic implications only in high-risk populations, such as patients with diabetes or manifest coronary artery disease (CAD), is uncertain. METHODS: We conducted a prospective cohort study of 1,236 consecutive patients with normal (99m)Tc-sestamibi MPI, defined as normal perfusion (summed stress score = 0) and normal left ventricle volume and function...
October 2013: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Paulo W Pires, Carla M Dams Ramos, Nusrat Matin, Anne M Dorrance
Maintenance of brain function depends on a constant blood supply. Deficits in cerebral blood flow are linked to cognitive decline, and they have detrimental effects on the outcome of ischemia. Hypertension causes alterations in cerebral artery structure and function that can impair blood flow, particularly during an ischemic insult or during periods of low arterial pressure. This review will focus on the historical discoveries, novel developments, and knowledge gaps in 1) hypertensive cerebral artery remodeling, 2) vascular function with emphasis on myogenic reactivity and endothelium-dependent dilation, and 3) blood-brain barrier function...
June 15, 2013: American Journal of Physiology. Heart and Circulatory Physiology
Nosheen Fatima, Maseeh u Zaman, Muhammad Ishaq, Dad J Baloch, Maryam Bano, Samreen Bano, Naila Bano, Nighat Bano
OBJECTIVES: The aim of the study was to determine the impact of glycosylated hemoglobin (HBA1C) on the extent of perfusion abnormalities and left ventricular dysfunction (LVD) using gated myocardial perfusion imaging (GMPI) and clinical outcomes in diabetic patients. MATERIALS AND METHODS: A total of 1013 individuals (457 diabetic patients and 556 nondiabetic controls) were included in the study. Among the diabetic patients, 254 (56%) were male and 203 (44%) were female, with a mean age of 58 ± 9 years...
May 2013: Nuclear Medicine Communications
Matteo Bartolini, Lucia Massi, Leonardo Settimo, Artur Mema, Alberto Pupi, Roberto Sciagrà
AIMS: The 3-min SBP ratio (SBPR) was proposed to detect significant coronary artery disease (CAD), but its relationship with abnormalities detected by myocardial perfusion-gated single-photon emission computed tomography (SPECT) was never examined. METHODS: In 156 consecutive patients submitted to resting and exercise gated SPECT for suspect CAD, perfusion scores, ejection fraction and transient ischemic dilatation (TID) were evaluated and compared with SBPR. RESULTS: There were weak correlations between SBPR and summed stress score (ρ = 0...
October 2013: Journal of Cardiovascular Medicine
Mario Petretta, Wanda Acampa, Stefania Daniele, Maria Piera Petretta, Carmela Nappi, Roberta Assante, Emilia Zampella, Pierluigi Costanzo, Pasquale Perrone-Filardi, Alberto Cuocolo
BACKGROUND: Transient ischemic dilation (TID) of the left ventricle during stress myocardial perfusion SPECT (MPS) has been shown to be a useful marker of severe coronary artery disease (CAD). However, investigations in diabetic patients with available coronary angiographic data are still limited. We evaluated the incremental diagnostic value of TID in identifying the presence of angiographically severe CAD in diabetic patients. METHODS AND RESULTS: TID ratio values were automatically derived from rest-stress MPS in 242 diabetic patients with available coronary angiography data...
February 2013: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Satoshi Hida, Taishiro Chikamori, Hirokazu Tanaka, Yuko Igarashi, Chie Shiba, Yasuhiro Usui, Tsuguhisa Hatano, Akira Yamashina
BACKGROUND: Although stress-induced left ventricular (LV) wall motion abnormality is a well-known marker for extensive coronary artery disease (CAD), no study has yet analyzed whether phase analysis of exercise-induced LV mechanical dyssynchrony may have enhanced diagnostic value over conventional perfusion analysis in the detection of multivessel CAD. METHODS AND RESULTS: A total of 278 patients with suspected or confirmed CAD underwent both exercise stress (99m)Tc-sestamibi gated single-photon emission computed tomography and coronary angiography...
2012: Circulation Journal: Official Journal of the Japanese Circulation Society
A Jimenez-Heffernan, E Sanchez de Mora, C Salgado, J Lopez-Martin, C Ramos, E Rodriguez-Gomez, A Tobaruela
BACKGROUND: In hemodialysis (HD) patients, the intravascular volume expansion of the pre-HD state leads to a high preload. We aim to examine its effect on myocardial perfusion gated SPECT (MPGS)-derived left ventricular (LV) volumes. METHODS: The study comprised 50 end-stage renal disease (ESRD) patients on HD with normal 2-day stress/rest MPGS performed for kidney transplantation risk assessment. Patients (pts) comprised 23 men/27 women, with mean age of 59.4 ± 7...
August 2012: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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