keyword
https://read.qxmd.com/read/38570727/comparative-single-cell-transcriptomic-profile-of-hybrid-immunity-induced-by-adenovirus-vector-based-covid-19-vaccines
#21
JOURNAL ARTICLE
Melissa García-Vega, Hui Wan, Mónica Reséndiz-Sandoval, Diana Hinojosa-Trujillo, Olivia Valenzuela, Verónica Mata-Haro, Freddy Dehesa-Canseco, Mario Solís-Hernández, Harold Marcotte, Qiang Pan-Hammarström, Jesús Hernández
In this study, antibody response and a single-cell RNA-seq analysis were conducted on peripheral blood mononuclear cells from five different groups: naïve subjects vaccinated with AZD1222 (AZ) or Ad5-nCoV (Cso), individuals previously infected and later vaccinated (hybrid) with AZD1222 (AZ-hb) or Ad5-nCoV (Cso-hb), and those who were infected and had recovered from COVID-19 (Inf). The results showed that AZ induced more robust neutralizing antibody responses than Cso. The single-cell RNA data revealed a high frequency of memory B cells in the Cso and Cso-hb...
April 3, 2024: Genes and Immunity
https://read.qxmd.com/read/38564289/proteomic-profiles-of-peritoneal-derived-small-extracellular-vesicles-correlate-with-outcome-in-ovarian-cancer-patients
#22
JOURNAL ARTICLE
Miguel Quiralte, Arantzazu Barquín, Mónica Yagüe Fernández, Paloma Navarro, Tatiana P Grazioso, Elena Sevillano, Juan F Rodriguez Moreno, Alejandra Balarezo-Saldivar, Héctor Peinado, Elena Izquierdo, Carlos Millán, Irene López Carrasco, Mario Prieto, Rodrigo Madurga de Lacalle, Ismael Fernández-Miranda, Sergio Ruiz-Llorente, Jesús García-Donas
Cancer-derived small extracellular vesicles (sEVs) are capable of modifying tumor microenvironment and promoting tumor progression. Ovarian cancer (OvCa) is a lethal malignancy that preferentially spreads through the abdominal cavity. Thus, the secretion of such vesicles into the peritoneal fluid could be a determinant factor in the dissemination and behavior of this disease. We designed a prospective observational study to assess the impact of peritoneal fluid-derived sEVs (PFD-sEVs) in OvCa clinical outcome...
April 2, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38563006/factors-associated-with-intention-to-be-vaccinated-with-the-covid-19-booster-dose-a-cross-sectional-study-in-peru
#23
JOURNAL ARTICLE
Rodrigo Camacho-Neciosup, Ericka N Balcazar-Huaman, Margarita L Alvarez-Vilchez, Janith P De la Cruz-Galán, Yubely Gálvez-Guadalupe, Edwin D Garcia-Muñoz, Greysi Cerron-Daga, Virgilio E Failoc-Rojas, Mario J Valladares-Garrido
INTRODUCTION: The pandemic of COVID-19 continues to impact people worldwide, with more than 755 million confirmed cases and more than 6.8 million reported deaths. Although two types of treatment, antiviral and immunomodulatory therapy, have been approved to date, vaccination has been the best method to control the spread of the disease. OBJECTIVE: To explore factors associated with the intention to be vaccinated with the COVID-19 booster dose in Peru. MATERIAL AND METHODS: Cross-sectional study, using virtual and physical surveys of adults with two or more doses of COVID-19 vaccine, where the dependent variable was the intention to be vaccinated (IBV) with the booster dose...
2024: PeerJ
https://read.qxmd.com/read/38559344/sars-cov-2-mutant-spectra-as-variant-of-concern-nurseries-endless-variation
#24
JOURNAL ARTICLE
Brenda Martínez-González, María Eugenia Soria, Pablo Mínguez, Ramón Lorenzo-Redondo, Llanos Salar-Vidal, Alberto López-García, Mario Esteban-Muñoz, Antoni Durán-Pastor, Pilar Somovilla, Carlos García-Crespo, Ana Isabel de Ávila, Jordi Gómez, Jaime Esteban, Ricardo Fernández-Roblas, Ignacio Gadea, Esteban Domingo, Celia Perales
INTRODUCTION: SARS-CoV-2 isolates of a given clade may contain low frequency genomes that encode amino acids or deletions which are typical of a different clade. METHODS: Here we use high resolution ultra-deep sequencing to analyze SARS-CoV-2 mutant spectra. RESULTS: In 6 out of 11 SARS-CoV-2 isolates from COVID-19 patients, the mutant spectrum of the spike (S)-coding region included two or more amino acids or deletions, that correspond to discordant viral clades...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38556450/modeling-childhood-cancer-in-drosophila-melanogaster
#25
JOURNAL ARTICLE
Isabel Adrados, Lucía García-López, Mario Aguilar-Aragon, Eva Maranillo, María Domínguez
Childhood cancer is a major cause of death in developed countries, and while treatments and survival rates have improved, long-term side effects remain a challenge. The genetic component of pediatric tumors and their aggressive progression, makes the study of childhood cancer a complex area of research. Here, we introduce the fruit fly Drosophila melanogaster as study model. We emphasize its numerous advantages, including binary gene expression systems that enable precise control over the timing and location of gene expression manipulation, the capacity to combine multiple genes associated with cancer or the testing of human cancer variants within a live, intact animal...
2024: Methods in Cell Biology
https://read.qxmd.com/read/38552312/risk-of-diabetes-mellitus-in-systemic-lupus-erythematosus-systematic-review-and-meta-analysis
#26
JOURNAL ARTICLE
Ivet Etchegaray-Morales, Claudia Mendoza-Pinto, Pamela Munguía-Realpozo, Juan Carlos Solis-Poblano, Socorro Méndez-Martínez, Jorge Ayón-Aguilar, Carlos Abud-Mendoza, Mario García-Carrasco, Ricard Cervera
OBJECTIVE: To investigate the risk of DM and evaluate the impact of SLE therapies on the risk of developing DM in patients with SLE. METHODS: Electronic database searches of PubMed, Embase, Cochrane Library, and Web of Science were performed from inception to February 2023. Cohort and cross-sectional studies that analyzed the risk of DM in patients with SLE were included. The associations between diabetes and antirheumatic agents, such as antimalarials and glucocorticoids, were analyzed in cohort studies...
March 29, 2024: Rheumatology
https://read.qxmd.com/read/38551349/-bacillus-subtilis-stress-associated-mutagenesis-and-developmental-dna-repair
#27
REVIEW
Mario Pedraza-Reyes, Karen Abundiz-Yañez, Alejandra Rangel-Mendoza, Lissett E Martínez, Rocío C Barajas-Ornelas, Mayra Cuéllar-Cruz, Hilda C Leyva-Sánchez, Víctor M Ayala-García, Luz I Valenzuela-García, Eduardo A Robleto
SUMMARY The metabolic conditions that prevail during bacterial growth have evolved with the faithful operation of repair systems that recognize and eliminate DNA lesions caused by intracellular and exogenous agents. This idea is supported by the low rate of spontaneous mutations (10-9 ) that occur in replicating cells, maintaining genome integrity. In contrast, when growth and/or replication cease, bacteria frequently process DNA lesions in an error-prone manner. DNA repairs provide cells with the tools needed for maintaining homeostasis during stressful conditions and depend on the developmental context in which repair events occur...
March 29, 2024: Microbiology and Molecular Biology Reviews: MMBR
https://read.qxmd.com/read/38547499/epidemiological-and-clinical-insights-into-the-enterovirus-d68-upsurge-in-europe-2021-22-and-the-emergence-of-novel-b3-derived-lineages-enpen-multicentre-study
#28
JOURNAL ARTICLE
Margarida Pires Simoes, Emma B Hodcroft, Peter Simmonds, Jan Albert, Enagon K Alidjinou, Katia Ambert-Balay, Cristina Andrés, Andrés Antón, Christelle Auvray, Jean-Luc Bailly, Fausto Baldanti, Capser Bastings, Stuart Beard, Carla Berengua Pereira, Natasa Berginc, Mandy Bloemen, Soile Blomqvist, Froukje Bosma, Sindy Böttcher, Laura Bubba, Stafan Buderus, Maria Cabrerizo, Christina Calvo, Christina Celma, Ferruccio Ceriotti, Gemma Clark, Inës Costa, Marianne Coste-Burel, Karen Couderé, Jeroen Cremer, Margarita Del Cuerpo Casas, Theo Daehne, Jessica de Beer, Maria de Ceano-Vivas, Cillian De Gascun, Alexis de Rougemont, Johnathan Dean, Jennifer L Dembinski, Sabine Diedrich, Javier Diez-Domingo, Lena Dillner, Dagny H Dorenberg, Alexandra Ducancelle, Susanne Dudman, Robert Dyrdak, Anna-Maria Eis-Huebinger, Iker Falces-Romero, Agnes Farkas, Susan Feeney, Maria D Fernandez-Garcia, Jacky Flipse, Kristina T Franck, Cristina Galli, Isabelle Garrigue, Felix Geeraedts, Irina Georgieva, Federica Giardina, Raquel Guiomar, Elenor Hauzenberger, Esther Heikens, Cécille Henquell, Didier Hober, Amrio Hönemann, Hannah Howson-Wells, Željka Hruškar, Niina Ikonen, Berthemarie Imbert, Arjan R Jansz, Marion Jeannoël, Helena Jiřincová, Laurence Josset, Kathrin Keeren, Naomie Kramer-Lindhout, Sidsel Krokstad, Mouna Lazrek, Hélène Le Guillou-Guillemette, Caroline Lefeuvre, Andreas Lind, Maja M Lunar, Melanie Maier, Stéphanie Marque-Juillet, C Patrick McClure, James McKenna, Adam Meijer, Ana Menasalvas Ruiz, Beatriz Mengual-Chuliá, Sofie Midgley, Audrey Mirand, Richard Molenkamp, Milagrosa Montes, Antonio Moreno-Docón, Ursula Morley, Jean-Luc Murk, Ana Navascués-Ortega, Roel Nijhuis, Lubomira Nikolaeva-Glomb, Svein A Nordbø, Sanela Numanovic, Massimo Oggioni, Eider Oñate Vergara, Jordi Pacaud, Marie L Pacreau, Marcus Panning, Elena Pariani, Lili Pekova, Laura Pellegrinelli, Miroslav Petrovec, Corinna Pietsch, Léa Pilorge, Luis Piñeiro, Antonio Piralla, Mario Poljak, Birgit Prochazka, Nuria Rabella, Janette C Rahamat-Langendoen, Petra Rainetova, Marijke Reynders, Annelies Riezebos-Brilman, Lieuwe Roorda, Carita Savolainen-Kopra, Isabelle Schuffenecker, Leo C Smeets, Ayse Stoyanova, Karl Stefic, Caroline Swanink, Irena Tabain, Jeroen Tjhie, Luc Thouault, Camille Tumiotto, Sara Uceda Renteria, Tina Uršič, Sophie Vallet, Marc Van Ranst, Peter Van Wunnik, Jaco J Verweij, Jorgina Vila, Bas Wintermans, Elke Wollants, Katja C Wolthers, F Xavier López-Labrado, Thea Kolsen Fischer, Heli Harvala, Kimberley S M Benschop
Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases...
March 28, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38543700/prognostic-value-of-d-dimer-to-lymphocyte-ratio-dlr-in-hospitalized-coronavirus-disease-2019-covid-19-patients-a-validation-study-in-a-national-cohort
#29
JOURNAL ARTICLE
Crhistian-Mario Oblitas, Pablo Demelo-Rodríguez, Luis-Antonio Alvarez-Sala-Walther, Manuel Rubio-Rivas, Francisco Navarro-Romero, Vicente Giner Galvañ, Lucía de Jorge-Huerta, Eva Fonseca Aizpuru, Gema María García García, José Luis Beato Pérez, Paula María Pesqueira Fontan, Arturo Artero Mora, Juan Antonio Vargas Núñez, Nuria Ramírez Perea, José Miguel García Bruñén, Emilia Roy Vallejo, Isabel Perales-Fraile, Ricardo Gil Sánchez, José López Castro, Ángel Luis Martínez González, Luis Felipe Díez García, Marina Aroza Espinar, José-Manuel Casas-Rojo, Jesús Millán Núñez-Cortés
BACKGROUND: This study aimed to validate the role of the D-dimer to lymphocyte ratio (DLR) for mortality prediction in a large national cohort of hospitalized coronavirus disease 2019 (COVID-19) patients. METHODS: A retrospective, multicenter, observational study that included hospitalized patients due to SARS-CoV-2 infection in Spain was conducted from March 2020 to March 2022. All biomarkers and laboratory indices analyzed were measured once at admission. RESULTS: A total of 10,575 COVID-19 patients were included in this study...
February 22, 2024: Viruses
https://read.qxmd.com/read/38533997/benchmark-outcomes-for-distal-pancreatectomy-a-multicenter-prospective-snapshot-study-spandispan
#30
JOURNAL ARTICLE
José M Ramia, Cándido F Alcázar-López, Celia Villodre-Tudela, Juan J Rubio-García, Belén Hernández, Daniel Aparicio-López, Mario Serradilla-Martín
BACKGROUND: Improving the quality of care is a priority for health systems to obtain better care and reduce costs. One of the tools for measuring quality is benchmarking (BM). We presented a one-country prospective study of distal pancreatectomies (DP) and determined BM. STUDY DESIGN: Prospective, multicenter, observational snapshot study of DP carried out at Spanish HPB centers for a year (February 22-January 23). HPB centers were defined as high-volume if they performed > 10 DP per year...
March 27, 2024: Journal of the American College of Surgeons
https://read.qxmd.com/read/38533127/decoding-the-historical-tale-covid-19-impact-on-haematological-malignancy-patients-epicovideha-insights-from-2020-to-2022
#31
JOURNAL ARTICLE
Jon Salmanton-García, Francesco Marchesi, Francesca Farina, Barbora Weinbergerová, Federico Itri, Julio Dávila-Valls, Sonia Martín-Pérez, Andreas Glenthøj, Ditte Stampe Hersby, Maria Gomes da Silva, Raquel Nunes Rodrigues, Alberto López-García, Raúl Córdoba, Yavuz M Bilgin, Iker Falces-Romero, Shaimaa El-Ashwah, Ziad Emarah, Caroline Besson, Milena Kohn, Jaap Van Doesum, Emanuele Ammatuna, Monia Marchetti, Jorge Labrador, Giovanni Paolo Maria Zambrotta, Luisa Verga, Ozren Jaksic, Marcio Nucci, Klára Piukovics, Alba Cabirta-Touzón, Moraima Jiménez, Elena Arellano, Ildefonso Espigado, Ola Blennow, Anna Nordlander, Stef Meers, Jens van Praet, Tommaso Francesco Aiello, Carolina Garcia-Vidal, Nicola Fracchiolla, Mariarita Sciumè, Guldane Cengiz Seval, Pavel Žák, Caterina Buquicchio, Carlo Tascini, Stefanie K Gräfe, Martin Schönlein, Tatjana Adžić-Vukičević, Valentina Bonuomo, Chiara Cattaneo, Summiya Nizamuddin, Martin Čerňan, Gaëtan Plantefeve, Romane Prin, Tomas Szotkovski, Graham P Collins, Michelina Dargenio, Verena Petzer, Dominik Wolf, Natasha Čolović, Lucia Prezioso, Toni Valković, Francesco Passamonti, Gustavo-Adolfo Méndez, Uluhan Sili, Antonio Vena, Martina Bavastro, Alessandro Limongelli, Rafael F Duarte, Marie-Pierre Ledoux, Milche Cvetanoski, Zlate Stojanoski, Marina Machado, Josip Batinić, Gabriele Magliano, Monika M Biernat, Nikola Pantić, Christian Bjørn Poulsen, Annarosa Cuccaro, Maria Ilaria Del Principe, Austin Kulasekararaj, Irati Ormazabal-Vélez, Alessandro Busca, Fatih Demirkan, Marriyam Ijaz, Nikolai Klimko, Igor Stoma, Sofya Khostelidi, Noemí Fernández, Ali S Omrani, Rui Bergantim, Nick De Jonge, Guillemette Fouquet, Milan Navrátil, Ghaith Abu-Zeinah, Michail Samarkos, Johan Maertens, Cristina De Ramón, Anna Guidetti, Ferenc Magyari, Tomás José González-López, Tobias Lahmer, Olimpia Finizio, Natasha Ali, László Imre Pinczés, Esperanza Lavilla-Rubira, Alessandra Romano, Maria Merelli, Mario Delia, Maria Calbacho, Joseph Meletiadis, Darko Antić, José-Ángel Hernández-Rivas, Joyce Marques de Almeida, Murtadha Al-Khabori, Martin Hoenigl, Maria Chiara Tisi, Nina Khanna, Aleksandra Barać, Noha Eisa, Roberta Di Blasi, Raphaël Liévin, Carolina Miranda-Castillo, Nathan C Bahr, Sylvain Lamure, Mario Virgilio Papa, Ayel Yahya, Avinash Aujayeb, Jan Novák, Nurettin Erben, María Fernández-Galán, José-María Ribera-Santa Susana, Ikhwan Rinaldi, Rita Fazzi, Monica Piedimonte, Rémy Duléry, Yung Gonzaga, Andrés Soto-Silva, Giuseppe Sapienza, Alexandra Serris, Ľuboš Drgoňa, Ana Groh, Laura Serrano, Eleni Gavriilaki, Athanasios Tragiannidis, Juergen Prattes, Nicola Coppola, Vladimir Otašević, Miloš Mladenović, Mirjana Mitrović, Bojana Mišković, Pavel Jindra, Sofia Zompi, Maria Vittoria Sacchi, Carolin Krekeler, Maria Stefania Infante, Daniel García-Bordallo, Gökçe Melis Çolak, Jiří Mayer, Marietta Nygaard, Michaela Hanáková, Zdeněk Ráčil, Matteo Bonanni, Philipp Koehler, Laman Rahimli, Oliver A Cornely, Livio Pagano
BACKGROUND: The COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading to more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, and monoclonal antibodies have been effective for the general population, their benefits for these patients may not be as pronounced. METHODS: The EPICOVIDEHA registry (National Clinical Trials Identifier, NCT04733729) gathers COVID-19 data from hematological malignancy patients since the pandemic's start worldwide...
May 2024: EClinicalMedicine
https://read.qxmd.com/read/38532961/quantifying-the-cost-of-shigella-diarrhea-in-the-enterics-for-global-health-efgh-shigella-surveillance-study
#32
JOURNAL ARTICLE
Chloe Morozoff, Naveed Ahmed, Jobiba Chinkhumba, Md Taufiqul Islam, Abdoulie F Jallow, Billy Ogwel, Loyda Fiorella Zegarra Paredes, Doh Sanogo, Hannah E Atlas, Henry Badji, Naor Bar-Zeev, Bakary Conteh, Mario Güimack Fajardo, Erika Feutz, Fadima C Haidara, Mehrab Karim, Adama Mamby Keita, Youssouf Keita, Farhana Khanam, Margaret N Kosek, Karen L Kotloff, Rebecca Maguire, Ishmail S Mbutuka, Maureen Ndalama, John Benjamin Ochieng, Collins Okello, Richard Omore, Karin F Perez Garcia, Farah Naz Qamar, Syed Qudrat-E-Khuda, Sonia Qureshi, Md Nazmul Hasan Rajib, Wagner Valentino Shapiama Lopez, Shazia Sultana, Desiree Witte, Mohammad Tahir Yousafzai, Alex O Awuor, Nigel A Cunliffe, M Jahangir Hossain, Maribel Paredes Olortegui, Milagritos D Tapia, K Zaman, Arianna Rubin Means
BACKGROUND: Comparative costs of public health interventions provide valuable data for decision making. However, the availability of comprehensive and context-specific costs is often limited. The Enterics for Global Health (EFGH) Shigella surveillance study-a facility-based diarrhea surveillance study across 7 countries-aims to generate evidence on health system and household costs associated with medically attended Shigella diarrhea in children. METHODS: EFGH working groups comprising representatives from each country (Bangladesh, Kenya, Malawi, Mali, Pakistan, Peru, and The Gambia) developed the study methods...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38531463/consistent-spatial-lesion-symptom-patterns-a-comprehensive-analysis-using-triangulation-in-lesion-symptom-mapping-in-a-cohort-of-stroke-patients
#33
JOURNAL ARTICLE
Gabriel Ramirez-Garcia, Ximena Escutia-Macedo, Douglas J Cook, Talia Moreno-Andrade, Estefania Villarreal-Garza, Mario Campos-Coy, Guillermo Elizondo-Riojas, Fernando Gongora-Rivera, Eduardo A Garza-Villarreal, Juan Fernandez-Ruiz
INTRODUCTION: The relationship between brain lesions and stroke outcomes is crucial for advancing patient prognosis and developing effective therapies. Stroke is a leading cause of disability worldwide, and it is important to understand the neurological basis of its varied symptomatology. Lesion-symptom mapping (LSM) methods provide a means to identify brain areas that are strongly associated with specific symptoms. However, inner variations in LSM methods can yield different results...
March 24, 2024: Magnetic Resonance Imaging
https://read.qxmd.com/read/38527468/a-global-tuberculosis-dictionary-unified-terms-and-definitions-for-the-field-of-tuberculosis
#34
JOURNAL ARTICLE
Alberto L Garcia-Basteiro, Joanna Ehrlich, Maryline Bonnet, Marianne Calnan, Stephen M Graham, Sabine Hermans, Adriana Jarrett, Rhoda Lewa, Anna Mandalakas, Leonardo Martinez, Giovanni Battista Migliori, Catherine W M Ong, Larissa Otero, Molebogeng Xheedha Rangaka, Mario C B Raviglione, Barbara Seaworth, Willy Ssengooba, Grant Theron, Anete Trajman, Marcel A Behr
No abstract text is available yet for this article.
March 22, 2024: Lancet Global Health
https://read.qxmd.com/read/38525854/efficacy-of-the-regional-mexican-diet-versus-the-mediterranean-diet-in-patients-with-masld-a-24-week-non-inferiority-trial
#35
JOURNAL ARTICLE
Ana Delfina Cano Contreras, Mario García Carvajal, Génesis Patricia Martínez Pérez, Airam Akire Ortiz Lorenzo, María Del Rocío Francisco, Héctor Ordaz Álvarez, Federico Roesch Dietlen, José María Remes-Troche
In the present manuscript we present evidence of the improvement of MASLD with dietary intervention. It is known that the Mediterranean diet is the best intervention for this pathology, however, it cannot be established in all countries due to the diversity of foods. We create a Mexican diet with the nutrients of the Mediterranean diet for the treatment of our population.
March 25, 2024: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/38519374/clinical-features-and-disease-progression-of-elderly-patients-at-the-icu-setting
#36
JOURNAL ARTICLE
Raquel Rodríguez-García, Loreto González-Lamuño, Mario Santullano, Beatriz Martín-Carro, Jose Luis Fernández-Martín, Maria Del Carmen Cienfuegos Basanta, Lorena Forcelledo, Carmen Palomo Antequera
OBJECTIVE: To describe and characterize a cohort of octogenarian patients admitted to the ICU of the University Central Hospital of Asturias (HUCA). DESIGN: Retrospective, observational and descriptive study of 14 months' duration. SETTING: Cardiac and Medical intensive care units (ICU) of the HUCA (Oviedo). PARTICIPANTS: Patients over 80 years old who were admitted to the ICU for more than 24 h. INTERVENTIONS: None...
March 21, 2024: Medicina intensiva
https://read.qxmd.com/read/38509034/estimating-causality-between-smoking-and-abdominal-obesity-by-mendelian-randomization
#37
JOURNAL ARTICLE
Germán D Carrasquilla, Mario García-Ureña, María J Romero-Lado, Tuomas O Kilpeläinen
BACKGROUND AND AIMS: Smokers tend to have a lower body weight than non-smokers, but also more abdominal fat. It remains unclear whether or not the relationship between smoking and abdominal obesity is causal. Previous Mendelian randomization (MR) studies have investigated this relationship by relying upon a single genetic variant for smoking heaviness. This approach is sensitive to pleiotropic effects and may produce imprecise causal estimates. We aimed to estimate causality between smoking and abdominal obesity using multiple genetic instruments...
March 20, 2024: Addiction
https://read.qxmd.com/read/38507317/isolated-posterior-acute-myocardial-infarction-the-responsible-for-subtle-changes-in-the-electrocardiogram
#38
JOURNAL ARTICLE
Mario R García-Arias, Cesar Y Salinas-Ulloa, Luis R Maravilla-Jiménez, Raúl Pinales-Salas
No abstract text is available yet for this article.
2024: Archivos de Cardiología de México
https://read.qxmd.com/read/38501336/viscous-dynamics-associated-with-hypoexcitation-and-structural-disintegration-in-neurodegeneration-via-generative-whole-brain-modeling
#39
JOURNAL ARTICLE
Carlos Coronel-Oliveros, Raúl Gónzalez Gómez, Kamalini Ranasinghe, Agustín Sainz-Ballesteros, Agustina Legaz, Sol Fittipaldi, Josephine Cruzat, Rubén Herzog, Gorsev Yener, Mario Parra, David Aguillon, Francisco Lopera, Hernando Santamaria-Garcia, Sebastián Moguilner, Vicente Medel, Patricio Orio, Robert Whelan, Enzo Tagliazucchi, Pavel Prado, Agustín Ibañez
INTRODUCTION: Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) lack mechanistic biophysical modeling in diverse, underrepresented populations. Electroencephalography (EEG) is a high temporal resolution, cost-effective technique for studying dementia globally, but lacks mechanistic models and produces non-replicable results. METHODS: We developed a generative whole-brain model that combines EEG source-level metaconnectivity, anatomical priors, and a perturbational approach...
March 19, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38500492/transient-acute-kidney-injury-after-chimeric-antigen-receptor-t-cell-therapy-in-patients-with-hematological-malignancies
#40
JOURNAL ARTICLE
Juan León-Román, Gloria Iacoboni, Sheila Bermejo, Cecilia Carpio, Mónica Bolufer, Clara García-Carro, Mario Sánchez-Salinas, Carla Alonso-Martínez, Oriol Bestard, Pere Barba, María José Soler
BACKGROUND: Acute kidney injury (AKI) occurs in 30% of patients infused with chimeric antigen receptor (CAR) T-cells. The purpose of this study was to identify risk factors and long-term outcomes after AKI in patients who received CAR T-cell therapy. METHODS: Medical records of 115 adult patients with R/R hematological malignancies treated with CD19-targeted CAR T-cells at Vall d'Hebron University Hospital between July 2018 and May 2021. Baseline demographic data including age, gender, ethnicity, body mass index (BMI), and co-morbidities, as well as the type of hematological neoplasia and prior lines of therapy were collected...
March 2024: Clinical Kidney Journal
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