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https://www.readbyqxmd.com/read/28339660/eculizumab-in-secondary-atypical-haemolytic-uraemic-syndrome
#1
Teresa Cavero, Cristina Rabasco, Antía López, Elena Román, Ana Ávila, Ángel Sevillano, Ana Huerta, Jorge Rojas-Rivera, Carolina Fuentes, Miquel Blasco, Ana Jarque, Alba García, Santiago Mendizabal, Eva Gavela, Manuel Macía, Luis F Quintana, Ana María Romera, Josefa Borrego, Emi Arjona, Mario Espinosa, José Portolés, Carolina Gracia-Iguacel, Emilio González-Parra, Pedro Aljama, Enrique Morales, Mercedes Cao, Santiago Rodríguez de Córdoba, Manuel Praga
Background.: Complement dysregulation occurs in thrombotic microangiopathies (TMAs) other than primary atypical haemolytic uraemic syndrome (aHUS). A few of these patients have been reported previously to be successfully treated with eculizumab. Methods.: We identified 29 patients with so-called secondary aHUS who had received eculizumab at 11 Spanish nephrology centres. Primary outcome was TMA resolution, defined by a normalization of platelet count (>150 × 10 9 /L) and haemoglobin, disappearance of all the markers of microangiopathic haemolytic anaemia (MAHA), and improvement of renal function, with a ≥25% reduction of serum creatinine from the onset of eculizumab administration...
February 20, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28330446/eudor-a-multi-centre-research-program-a-naturalistic-european-multi-centre-clinical-study-of-edor-test-in-adult-patients-with-primary-depression
#2
Marco Sarchiapone, Miriam Iosue, Vladimir Carli, Mario Amore, Enrique Baca-Garcia, Anil Batra, Doina Cosman, Philippe Courtet, Guido Di Sciascio, Ricardo Gusmao, Tadeusz Parnowski, Peter Pestality, Pilar Saiz, Johannes Thome, Anders Tingström, Marcin Wojnar, Patrizia Zeppegno, Lars-Håkan Thorell
BACKGROUND: Electrodermal reactivity has been successfully used as indicator of interest, curiosity as well as depressive states. The measured reactivity depends on the quantity of sweat secreted by those eccrine sweat glands that are located in the hypodermis of palmar and plantar regions. Electrodermal hyporeactive individuals are those who show an unusual rapid habituation to identical non-significant stimuli. Previous findings suggested that electrodermal hyporeactivity has a high sensitivity and a high specificity for suicide...
March 23, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28329248/clinical-characteristics-of-wild-type-transthyretin-cardiac-amyloidosis-disproving-myths
#3
Esther González-López, Christian Gagliardi, Fernando Dominguez, Cristina Candida Quarta, F Javier de Haro-Del Moral, Agnese Milandri, Clara Salas, Mario Cinelli, Marta Cobo-Marcos, Massimiliano Lorenzini, Enrique Lara-Pezzi, Serena Foffi, Luis Alonso-Pulpon, Claudio Rapezzi, Pablo Garcia-Pavia
Aims: Wild-type transthyretin amyloidosis (ATTRwt) is mostly considered a disease predominantly of elderly male, characterized by concentric LV hypertrophy, preserved LVEF, and low QRS voltages. We sought to describe the characteristics of a large cohort of ATTRwt patients to better define the disease. Methods and results: Clinical findings of consecutive ATTRwt patients diagnosed at 2 centres were reviewed. ATTRwt was diagnosed histologically or non-invasively (LV hypertrophy ≥12 mm, intense cardiac uptake at 99mTc-DPD scintigraphy and AL exclusion)...
March 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28328784/direct-xa-inhibitors-in-addition-to-antiplatelet-therapy-in-acute-coronary-syndrome-meta-analysis-of-randomized-trials
#4
Pedro A Villablanca, David Holmes, Divyanshu Mohananey, David F Briceno, Ivan J Núñez Gil, Faraj Kargoli, Tanush Gupta, Jorge R Kizer, Anna E Bortnick, Jose Wiley, Mark A Menegus, Robert Pyo, Mario García, Harish Ramakrishna, Farouk Mookadam
OBJECTIVE: We carried out a meta-analysis summarizing the efficacy and safety of direct factor Xa inhibitor (DXI) in patients receiving guideline-based antiplatelet therapy (GBAT) after an acute coronary syndrome. BACKGROUND: Randomized-controlled trials have shown that the addition of a DXI to GBAT after acute coronary syndrome can reduce ischemic events, the trade-off being an increase in major bleeding complications. METHODS: PubMed, Central, Embase, The Cochrane Register, Google Scholar databases, and the scientific session abstracts were searched for eligible randomized trials from 1 January 1990 through 31 December 2016...
March 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28323193/spread-of-a-new-c-trachomatis-variant-from-men-who-have-sex-with-men-to-the-heterosexual-population-after-the-replacement-and-recombination-in-ompa-and-pmph-genes
#5
Mario Rodríguez-Domínguez, José María González-Alba, Teresa Puerta, Laura Martínez-García, Blanca Menéndez, Rafael Cantón, Jorge Del Romero, Juan Carlos Galán
OBJECTIVES: Sexually transmitted infections are frequently related to outbreaks in high-risk populations due to the dense sexual networks. We wanted to determine the dissemination of a C. trachomatis variant characterized by pmpH-recombinant gene between L and G genotypes, which was previously described in a high-risk population. METHODS: 449 samples were analysed in two periods ranging from 2009-2015 for detection of pmpH-recombinant gene. For those samples yielding positive amplification, a sampling was selected for phylogenetic reconstructions based on sequencing of five chromosomal genes...
March 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28316600/methylation-of-foxp3-tsdr-underlies-the-impaired-suppressive-function-of-tregs-from-long-term-belatacept-treated-kidney-transplant-patients
#6
Evelyn Katy Alvarez Salazar, Arimelek Cortés-Hernández, Germán Rodrigo Alemán-Muench, Josefina Alberú, Jesús R Rodríguez-Aguilera, Félix Recillas-Targa, Victoria Chagoya de Sánchez, Eric Cuevas, Eduardo Mancilla-Urrea, María Pérez García, Guillermo Mondragón-Ramírez, Mario Vilatobá, Ian Bostock, Erick Hernández-Méndez, David De Rungs, Eduardo A García-Zepeda, Gloria Soldevila
Regulatory T cells (Tregs) are considered key players in the prevention of allograft rejection in transplanted patients. Belatacept (BLT) is an effective alternative to calcineurin inhibitors that appears to preserve graft survival and function; however, the impact of this drug in the homeostasis of Tregs in transplanted patients remains controversial. Here, we analyzed the phenotype, function, and the epigenetic status of the Treg-specific demethylated region (TSDR) in FOXP3 of circulating Tregs from long-term kidney transplant patients under BLT or Cyclosporine A treatment...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28301013/influence-of-different-dentin-substrate-caries-affected-caries-infected-sound-on-long-term-%C3%AE-tbs
#7
Ana Rosa Costa, Franklin Garcia-Godoy, Lourenço Correr-Sobrinho, Lucas Zago Naves, Luís Henrique Araújo Raposo, Fabíola Galbiatti de Carvalho, Mário Alexandre Coelho Sinhoreti, Regina Maria Puppin-Rontani
The aim of this study was to evaluate the μTBS in different dentin substrates and water-storage periods. Twenty-four dentin blocks obtained from sound third molars were randomly divided into 3 groups: Sound dentin (Sd), Caries-affected dentin (Ca) and Caries-infected dentin (Ci). Dentin blocks from Ca and Ci groups were subjected to artificial caries development (S. mutans biofilm). The softest carious tissue was removed using spherical drills under visual inspection with Caries Detector solution (Ca group)...
January 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28295282/genital-mycoplasma-infection-among-mexican-women-with-systemic-lupus-erythematosus
#8
Socorro Méndez-Martínez, Mario García-Carrasco, María L Cedillo-Ramírez, Claudia Mendoza-Pinto, Ivet Etchegaray-Morales, Constantino Gil-Juárez, Álvaro J Montiel-Jarquín, Alejandro Taboada-Cole, Erick A Jiménez-Herrera, Margarita Muñóz-Guarneros, Ricard Cervera
OBJECTIVE: To assess the prevalence of genital Mycoplasma spp. among women with systemic lupus erythematosus (SLE) and to identify factors associated with such infection. METHODS: A cross-sectional study was conducted among patients with SLE and healthy women who attended a hospital in Puebla, Mexico, between July 29, 2014, and January 4, 2015. All participants were aged 18 years or older and sexually active. A structured interview assessed sociodemographic, obstetric, gynecologic, and clinical characteristics...
March 15, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28282933/the-diabetes-linked-transcription-factor-pax4-from-gene-to-functional-consequences
#9
REVIEW
Petra I Lorenzo, Francisco Juárez-Vicente, Nadia Cobo-Vuilleumier, Mario García-Domínguez, Benoit R Gauthier
Paired box 4 (PAX4) is a key factor in the generation of insulin producing β-cells during embryonic development. In adult islets, PAX4 expression is sequestered to a subset of β-cells that are prone to proliferation and more resistant to stress-induced apoptosis. The importance of this transcription factor for adequate pancreatic islets functionality has been manifested by the association of mutations in PAX4 with the development of diabetes, independently of its etiology. Overexpression of this factor in adult islets stimulates β-cell proliferation and increases their resistance to apoptosis...
March 9, 2017: Genes
https://www.readbyqxmd.com/read/28274189/intracerebroventricular-administration-of-the-1%C3%A2-6-%C3%AE-d-glucan-lasiodiplodan-in-male-rats-prevents-d-penicillamine-induced-behavioral-alterations-and-lipoperoxidation-in-the-cortex
#10
Carlos Ricardo Maneck Malfatti, Fabio Seidel Dos Santos, Jéssica Wouk, Luiz Augusto da Silva, Renan Garcia Michel, André Luiz Snak, Tiago Czervinski, Mário A Alves da Cunha, Aneli M Barbosa, Robert F H Dekker
CONTEXT: Lasiodiplodan, an exocellular (1→6)-β-d-glucan of molecular weight >1.4 × 10(6) Da produced by MMPI strain of Lasiodiplodia theobromae (Pat.) Griffon & Maubl. (Brotyosphaeriaceae) is known to exhibit anti-proliferative activity on breast cancer cells (MCF-7), anticoagulant activity when sulfonylated, and reduction in transaminase activity when administered in rats. OBJECTIVE: The effect of intracerebroventricular (I.C.V) injection of lasiodiplodan on neurotoxicity and behavioural changes induced by d-penicillamine was investigated...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28254733/bioengineered-temporomandibular-joint-disk-implants-study-protocol-for-a-two-phase-exploratory-randomized-preclinical-pilot-trial-in-18-black-merino-sheep-tempojims
#11
David Faustino Ângelo, Florencio Gil Monje, Raúl González-García, Christopher B Little, Lisete Mónico, Mário Pinho, Fábio Abade Santos, Belmira Carrapiço, Sandra Cavaco Gonçalves, Pedro Morouço, Nuno Alves, Carla Moura, Yadong Wang, Eric Jeffries, Jin Gao, Rita Sousa, Lia Lucas Neto, Daniel Caldeira, Francisco Salvado
BACKGROUND: Preclinical trials are essential to test efficacious options to substitute the temporomandibular joint (TMJ) disk. The contemporary absence of an ideal treatment for patients with severe TMJ disorders can be related to difficulties concerning the appropriate study design to conduct preclinical trials in the TMJ field. These difficulties can be associated with the use of heterogeneous animal models, the use of the contralateral TMJ as control, the absence of rigorous randomized controlled preclinical trials with blinded outcomes assessors, and difficulties involving multidisciplinary teams...
March 2, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28248680/giardia-duodenalis-genotypes-among-schoolchildren-and-their-families-and-pets-in-urban-and-rural-areas-of-sinaloa-mexico
#12
Patricia Catalina García-Cervantes, María Elena Báez-Flores, Francisco Delgado-Vargas, Martha Ponce-Macotela, Yukifumi Nawa, María Del-Carmen De-la-Cruz-Otero, Mario N Martínez-Gordillo, Sylvia Páz Díaz-Camacho
INTRODUCTION: Giardiasis is a human health concern worldwide, especially among schoolchildren. Giardia duodenalis genotypes A and B are infective to humans, but their zoonotic potential remains controversial. In Mexico, the most prevalent genotype is A, but B was also detected in southeastern Mexico. In Sinaloa state, northwestern Mexico, giardiasis is highly prevalent, but Giardia genotypes have been poorly studied. METHODOLOGY: This study aimed to investigate the distribution and clinical-epidemiological correlation of G...
February 28, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28248445/prevalence-and-distribution-of-hepatitis-c-virus-genotypes-in-spain-during-the-2000-2015-period-the-gehep-005-study
#13
Antonio Aguilera, Daniel Navarro, Francisco Rodríguez Frias, Isabel Viciana, Ana María Martínez-Sapiña, Mario José Rodríguez, Elisa Martró, María Del Carmen Lozano, Eleda Coletta, Laura Cardeñoso, Avelina Suárez, Matilde Trigo, Javier Rodríguez-Granjer, Natalia Montiel, Alberto de la Iglesia, Juan Carlos Alados, Cesar Vegas, Samuel Bernal, Felipe Fernández-Cuenca, María José Pena, Gabriel Reina, Silvia García-Bujalance, María Julia Echevarria, Laura Benítez, Sonia Pérez-Castro, Dolores Ocete, Isabel García-Arata, Carmen Guerrero, Manuel Rodríguez-Iglesias, Paz Casas, Federico García
AIM: We report the largest study on the prevalence and distribution of HCV genotypes in Spain (2000-2015), and we relate them with clinical, epidemiological and virological factors. METHODS: Patients from 29 hospitals in 10 autonomous communities (Andalusia, Aragon, Castilla-Leon, Catalonia, Galicia, Canary Islands, Madrid-Community, Valencian-Community, Murcia Region and Basque Country) have been studied. Annual distribution of HCV genotypes and subtypes, as well as gender, age, transmission route, HIV and/or HBV-coinfection, and treatment details were recorded...
March 1, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28244702/health-insurance-or-subsidy-has-universal-advantage-for-management-of-hospital-malnutrition-unrelated-to-gdp
#14
Stanislaw Klek, Michael Chourdakis, Dima Abdulqudos Abosaleh, Alejandra Amestoy, Hyun Wook Baik, Gertrudis Baptista, Rocco Barazzoni, Ryoji Fukushima, Josef Hartono, Ranil Jayawardena, Rafael Jimenez Garcia, Zeljko Krznaric, Ibolya Nyulasi, Gabriela Parallada, Eliza Mei Perez Francisco, Marina Panisic-Sekeljic, Mario Perman, Arina Prins, Isabel Martinez Del Rio Requejo, Ravinder Reddy, Pierre Singer, Marianna Sioson, Andrew Ukleja, Carla Vartanian, Nicolas Velasco Fuentes, Dan Linetzky Waitzberg, Steve Leonce Zoungrana, Aleksander Galas
BACKGROUND AND OBJECTIVES: Protein-energy and micronutrient malnutrition are global public health problems which, when not prevented and severe, require medical management by clinicians with nutrition expertise, preferably as a collectively skilled team, especially when disease-related. This study aimed to investigate barriers and facilitators of clinical nutrition services (CNS), especially the use of oral, enteral (EN) and parenteral (PN) nutrition in institutional and home settings...
March 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28237027/cholesterol-plays-a-larger-role-during-mycobacterium-tuberculosis-in%C3%A2-vitro-dormancy-and-reactivation-than-previously-suspected
#15
Maria D Soto-Ramirez, Diana A Aguilar-Ayala, Lazaro Garcia-Morales, Sofia M Rodriguez-Peredo, Claudia Badillo-Lopez, Diana E Rios-Muñiz, Mario A Meza-Segura, Gelen Y Rivera-Morales, Lizbel Leon-Solis, Jorge F Cerna-Cortes, Sandra Rivera-Gutierrez, Addy C Helguera-Repetto, Jorge A Gonzalez-Y-Merchand
It is known that cholesterol plays a key role for Mycobacterium tuberculosis (Mtb) adaptation and survival within the host, thus contributing to the establishment of dormancy. It has been extensively demonstrated that fatty acids are the main energy source of Mtb during infection and dormancy, and it has been proposed that these molecules are implicated in reactivation of bacilli from a dormant state. We used in vitro models to analyze Mtb gene expression during dormancy and reactivation when fatty acids and cholesterol are the unique carbon source in the media...
March 2017: Tuberculosis
https://www.readbyqxmd.com/read/28220327/genetic-characterization-of-cacipacor%C3%A3-virus-from-ticks-collected-in-s%C3%A3-o-paulo-state-brazil
#16
Glauciane Garcia de Figueiredo, Alberto Anastacio Amarilla, William Marciel de Souza, Marcílio Jorge Fumagalli, Mário Luis Garcia de Figueiredo, Matias Pablo Juan Szabó, Soraya Jabur Badra, Yin Xiang Setoh, Alexander A Khromykh, Victor Hugo Aquino, Luiz Tadeu Moraes Figueiredo
Cacipacoré virus (CPCV) is a potential emerging virus classified in the genus Flavivirus, family Flaviviridae. In the present study, we present the genetic characterization of a CPCV isolated from ticks (Amblyomma cajennense) collected from a sick capybara (Hydrochoerus hydrochaeris) in São Paulo State, Brazil. The CPCV isolate shares the typical genomic organization of flaviviruses with 10,857 nucleotides in length and a single open reading frame of 10,284 nucleotides encoding a polyprotein of 3,427 amino acids...
February 20, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28214712/epidemiological-study-of-mortality-in-epilepsy-in-a-spanish-population
#17
María Isabel Chamorro-Muñoz, Guillermina García-Martín, Francisco Pérez-Errazquin, Manuel Romero-Acebal, Antonio García-Rodríguez, Mario Gutiérrez-Bedmar
PURPOSE: Studies concerning mortality in epilepsy have been performed primarily in Northern-Central Europe and US. The aim of this study was to provide information about mortality in people with epilepsy in Southern European countries. METHOD: We studied a Spanish prevalence and incidence cohort of 2309 patients aged ≥14 years with epilepsy who were treated in an outpatient epilepsy clinic between 2000 and 2013. The deceased were identified through Civil Registries...
February 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28211481/effects-of-strength-training-on-osteogenic-differentiation-and-bone-strength-in-aging-female-wistar-rats
#18
Monique Patricio Singulani, Camila Tami Stringhetta-Garcia, Leandro Figueiredo Santos, Samuel Rodrigues Lourenço Morais, Mário Jefferson Quirino Louzada, Sandra Helena Penha Oliveira, Antonio Hernandes Chaves Neto, Rita Cássia Menegati Dornelles
The effects of strength training (ST) on the mechanical bone strength and osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) from adult, aged and exercised aged rats were determined. The exercised aged animals displayed higher values of areal bone mineral density, compression test, alkaline phosphatase activity (ALP) and biological mineralization, while oil red O staining for adipocytes was lower. ST increased gene expression of runt-related transcription factor 2 (Runx2), osterix (Osx) as well as bone matrix protein expression, and reduced expression of peroxisome proliferator-activated receptor gamma (Pparγ)...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28204197/circulating-ghrelin-acts-on-gaba-neurons-of-the-area-postrema-and-mediates-gastric-emptying-in-male-mice
#19
Agustina Cabral, María P Cornejo, Gimena Fernandez, Pablo N De Francesco, Guadalupe Garcia-Romero, Maia Uriarte, Jeffrey M Zigman, Enrique Portiansky, Mirta Reynaldo, Mario Perello
No abstract text is available yet for this article.
February 15, 2017: Endocrinology
https://www.readbyqxmd.com/read/28188434/bloodless-reperfusion-with-the-oxygen-carrier-hboc-201-in-acute-myocardial-infarction-a-novel-platform-for-cardioprotective-probes-delivery
#20
Jose M García-Ruiz, Carlos Galán-Arriola, Rodrigo Fernández-Jiménez, Jaume Aguero, Javier Sánchez-González, Ana García-Alvarez, Mario Nuno-Ayala, Gregory P Dubé, Zafiris Zafirelis, Gonzalo J López-Martín, Juan A Bernal, Enrique Lara-Pezzi, Valentín Fuster, Borja Ibáñez
Reperfusion, despite being required for myocardial salvage, is associated with additional injury. We hypothesize that infarct size (IS) will be reduced by a period of bloodless reperfusion with hemoglobin-based oxygen carriers (HBOC) before blood-flow restoration. In the pig model, we first characterized the impact of intracoronary perfusion with a fixed volume (600 ml) of a pre-oxygenated acellular HBOC, HBOC-201, on the healthy myocardium. HBOC-201 was administered through the lumen of the angioplasty balloon (i...
March 2017: Basic Research in Cardiology
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