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https://www.readbyqxmd.com/read/29929701/diagnostic-challenges-and-future-perspectives-in-fracture-related-infection
#1
Mario Morgenstern, Richard Kühl, Henrik Eckardt, Yves Acklin, Barbara Stanic, Meritxell Garcia, Daniel Baumhoer, Willem-Jan Metsemakers
Fracture-related infection (FRI) is one of the most challenging complications in orthopaedic trauma surgery. It has severe consequences for patients and an important socio-economic impact. FRI has distinct properties and needs to be addressed interdisciplinary. Since criteria for the diagnosis of FRI are not standardized, an expert panel recently proposed a definition for FRI. In this review the current diagnostic modalities and an interdisciplinary diagnostic algorithm based on this recently published definition, are presented and future diagnostic techniques discussed...
June 2018: Injury
https://www.readbyqxmd.com/read/29924282/-polymorphisms-of-the-arsenite-methyltransferase-as3mt-gene-and-urinary-efficiency-of-arsenic-metabolism-in-a-population-in-northern-mexico
#2
Francisco Javier García-Alvarado, Honorio Neri-Meléndez, Luz Pérez Armendáriz, Mario Rivera Guillen
The aim of this study was to assess the relationship of the rs11191439 and rs3740393 polymorphisms of the Arsenite Methyltransferase (As3MT) gene with the arsenic urinary excretion profiles in a population in northern Mexico. A crosssectional study was conducted with 102 participants between the ages of 14 and 75 in Comarca Lagunera, Mexico. Speciation of the arsenic urinary metabolites was determined, and DNA was extracted; analysis and amplification of the polymorphisms was made by PCR in real time. A descriptive analysis was carried out and the differences in the urinary arsenic concentrations were assessed according to sex and genotype...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29922082/pharmacogenetic-association-study-on-clopidogrel-response-in-puerto-rican-hispanics-with-cardiovascular-disease-a-novel-characterization-of-a-caribbean-population
#3
Dagmar F Hernandez-Suarez, Mariana R Botton, Stuart A Scott, Matthew I Tomey, Mario J Garcia, Jose Wiley, Pedro A Villablanca, Kyle Melin, Angel Lopez-Candales, Jessicca Y Renta, Jorge Duconge
Introduction: High on-treatment platelet reactivity (HTPR) to clopidogrel imparts an increased risk for ischemic events in adults with coronary artery disease. Platelet reactivity varies with ethnicity and is influenced by both clinical and genetic variables; however, no clopidogrel pharmacogenetic studies with Puerto Rican patients have been reported. Therefore, we sought to identify clinical and genetic determinants of on-treatment platelet reactivity in a cohort of Puerto Rican patients with cardiovascular disease...
2018: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/29914394/mortality-and-associated-risk-factors-for-older-adults-admitted-to-the-emergency-department-a-hospital-cohort
#4
Carmen García-Peña, Mario Ulises Pérez-Zepeda, Leslie Viridiana Robles-Jiménez, Sergio Sánchez-García, Ricardo Ramírez-Aldana, Pamela Tella-Vega
BACKGROUND: Older emergency department patients are more vulnerable than younger patients, yet many risk factors that contribute to the mortality of older patients remain unclear and under investigation. This study endeavored to determine mortality and factors associated with mortality in patients over 60 years of age who were admitted to the emergency departments of two general hospitals in Mexico City. METHODS: This is a hospital cohort study involving adults over 60 years of age admitted to the emergency department and who are beneficiaries of the Mexican Institute of Social Security and residents of Mexico City...
June 18, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29912473/cross-cultural-validation-of-the-5-factor-structure-of-negative-symptoms-in-schizophrenia
#5
Anthony O Ahmed, Brian Kirkpatrick, Silvana Galderisi, Armida Mucci, Alessandro Rossi, Alessandro Bertolino, Paola Rocca, Mario Maj, Stefan Kaiser, Martin Bischof, Matthias N Hartmann-Riemer, Matthias Kirschner, Karoline Schneider, Maria Paz Garcia-Portilla, Anna Mane, Miguel Bernardo, Emilio Fernandez-Egea, Cui Jiefeng, Yao Jing, Tan Shuping, James M Gold, Daniel N Allen, Gregory P Strauss
Objective: Negative symptoms are currently viewed as having a 2-dimensional structure, with factors reflecting diminished expression (EXP) and motivation and pleasure (MAP). However, several factor-analytic studies suggest that the consensus around a 2-dimensional model is premature. The current study investigated and cross-culturally validated the factorial structure of BNSS-rated negative symptoms across a range of cultures and languages. Method: Participants included individuals diagnosed with a psychotic disorder who had been rated on the Brief Negative Symptom Scale (BNSS) from 5 cross-cultural samples, with a total N = 1691...
April 18, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29910332/relationships-between-sprint-ability-and-endurance-capacity-in-soccer-referees
#6
Mario Sánchez-García, Javier Sánchez-Sánchez, Alejandro Rodríguez-Fernández, David Solano, Daniel Castillo
The aim of this study was to analyze the association between sprint ability and endurance capacity in soccer referees. Twenty-three Spanish officials participated in this study. Each referee undertook, in this order, a 40 m linear straight sprinting test (40 m Sprint) and the Yo⁻Yo intermittent recovery level 1 test (YYIR1) interspersed with a 8 min of self-administered rest. The results in the 40 m Sprint test showed that the time spent by referees was 5.56 ± 0.27 s and achieved a maximum velocity of 31...
March 30, 2018: Sports
https://www.readbyqxmd.com/read/29909113/coronary-computed-tomography-angiography-versus-stress-echocardiography-in-acute-chest-pain-a-randomized-controlled-trial
#7
Jeffrey M Levsky, Linda B Haramati, Daniel M Spevack, Mark A Menegus, Terence Chen, Sarah Mizrachi, Durline Brown-Manhertz, Samantha Selesny, Rikah Lerer, Deborah J White, Jonathan N Tobin, Cynthia C Taub, Mario J Garcia
OBJECTIVES: This study sought to compare early emergency department (ED) use of coronary computed tomography angiography (CTA) and stress echocardiography (SE) head-to-head. BACKGROUND: Coronary CTA has been promoted as the early ED chest pain triage imaging method of choice, whereas SE is often overlooked in this setting and involves no ionizing radiation. METHODS: The authors randomized 400 consecutive low- to intermediate-risk ED acute chest pain patients without known coronary artery disease and a negative initial serum troponin level to immediate coronary CTA (n = 201) or SE (n = 199)...
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29907903/the-chemokine-ccl4-mip-1%C3%AE-evokes-antinociceptive-effects-in-mice-a-role-for-cd4-lymphocytes-and-met-enkephalin
#8
Mario García-Domínguez, Ana Lastra, Alicia R Folgueras, Rafael Cernuda-Cernuda, María Teresa Fernández-García, Agustín Hidalgo, Luis Menéndez, Ana Baamonde
In the present study, we characterize the antinociceptive effects produced by the chemokine CCL4 in mice. The intraplantar administration of very low doses of CCL4 (0.1-3 pg) produced bilateral antinociception assessed by the unilateral hot-plate test (UHP) without evoking chemotactic responses at the injection site. Moreover, the subcutaneous administration of CCL4 (3-100 pg/kg) also yielded bilateral antinociception in the UHP and the paw pressure test and reduced the number of spinal neurons that express Fos protein in response to noxious stimulation...
June 15, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29905668/multimodal-imaging-in-a-case-of-central-retinal-artery-occlusion-in-the-presence-of-type-2-macular-telangiectasia
#9
Mariana Ingolotti, Enrique Alfonso Roig Melo-Granados, Pedro Mario González-Madrigal, Humberto Ruiz García
PURPOSE: To report a case of central retinal artery occlusion in a patient with macular telangiectasia Type 2 using multimodal imaging. METHODS: Observational case report. RESULTS: A 58-year-old woman who presented with acute painless unilateral vision loss was diagnosed with central retinal artery occlusion in her right eye with macular telangiectasia Type 2 findings in both eyes. Fundus examination revealed retinal whitening with unusual cherry-red spot plus small crystalline deposits in the temporal macula...
June 13, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29900998/beta-2-microglobulin-in-whole-unstimulated-saliva-can-effectively-distinguish-between-sj%C3%A3-gren-s-syndrome-and-non-autoimmune-sicca-symptoms
#10
Janett Riega-Torres, Guillermo Delgado-García, Julio César Salas-Alanís, Cassandra Skinner-Taylor, Lorena Pérez-Barbosa, Mario Garza-Elizondo, Celia Nohemí Sánchez-Domínguez, Luis Ángel Ceceñas-Falcón, Karim Mohamed-Noriega, Jesús Mohamed-Hamsho, David Vega-Morales
Objectives: This study aims to describe salivary beta-2 microglobulin (sB2M) levels in our setting and to assess the performance of sB2M for the diagnosis of Sjögren's syndrome (SS). Patients and methods: This cross-sectional, comparative study included 192 SS patients (2 males, 190 females; mean age 53.1 years; range 23 to 84 years) and 64 healthy controls (1 male, 63 females; mean age 46.9 years; range 21 to 82 years). Patients were divided into three groups as those with primary SS, secondary SS, and sicca non-Sjögren's syndrome (snSS)...
December 2017: Archives of Rheumatology
https://www.readbyqxmd.com/read/29899831/epigenetic-dysregulation-of-tet2-in-human-glioblastoma
#11
María G García, Antonella Carella, Rocío G Urdinguio, Gustavo F Bayón, Virginia Lopez, Juan Ramón Tejedor, Marta I Sierra, Estela García-Toraño, Pablo Santamarina, Raúl F Perez, Cristina Mangas, Aurora Astudillo, M Daniela Corte-Torres, Inés Sáenz-de-Santa-María, María-Dolores Chiara, Agustín F Fernández, Mario F Fraga
Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that TET2 shows frequent epigenetic alterations in human glioblastoma including DNA hypermethylation and hypo-hydroxymethylation, as well as loss of histone acetylation. Ectopic overexpression of TET2 regulated neural differentiation in glioblastoma cell lines and impaired tumor growth. Our results suggest that epigenetic dysregulation of TET2 plays a role in human glioblastoma...
May 25, 2018: Oncotarget
https://www.readbyqxmd.com/read/29897913/bone-mineral-density-and-vertebral-fractures-in-patients-with-systemic-lupus-erythematosus-a-systematic-review-and-meta-regression
#12
Claudia Mendoza-Pinto, Adriana Rojas-Villarraga, Nicolás Molano-González, Erick A Jiménez-Herrera, María de la Luz León-Vázquez, Álvaro Montiel-Jarquín, Mario García-Carrasco, Ricard Cervera
BACKGROUND: Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VF) in patients with systemic lupus erythematosus (SLE). Therefore, the objectives of this systematic review and meta-regression were: 1) to compare BMD between SLE patients and healthy controls and 2) to evaluate the relationship between BMD and glucocorticoid therapy and VF in SLE patients. METHODS AND FINDINGS: Articles were identified from electronic databases (PubMed, Embase, VHL, SciELO and the Cochrane Library)...
2018: PloS One
https://www.readbyqxmd.com/read/29887869/inhibitory-role-of-growth-hormone-in-the-induction-and-progression-phases-of-collagen-induced-arthritis
#13
Ricardo Villares, Gabriel Criado, Yasmina Juarranz, Mercedes Lopez-Santalla, Eva M García-Cuesta, José M Rodríguez-Frade, Javier Leceta, Pilar Lucas, José Luis Pablos, Carlos Martínez-A, Marina I Garin, Rosa P Gomariz, Mario Mellado
Evidence indicates an intimate connection between the neuroendocrine and the immune systems. A number of in vitro and in vivo studies have demonstrated growth hormone (GH) involvement in immune regulation. The GH receptor is expressed by several leukocyte subpopulations, and GH modulates immune cell proliferation and activity. Here, we found that sustained GH expression protected against collagen-induced arthritis (CIA); in GH-transgenic C57BL/6 (GHTg) mice, disease onset was delayed, and its overall severity was decreased...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29884186/exhaustion-of-mitochondrial-and-autophagic-reserve-may-contribute-to-the-development-of-lrrk2-g2019s-parkinson-s-disease
#14
Diana Luz Juárez-Flores, Ingrid González-Casacuberta, Mario Ezquerra, María Bañó, Francesc Carmona-Pontaque, Marc Catalán-García, Mariona Guitart-Mampel, Juan José Rivero, Ester Tobias, Jose Cesar Milisenda, Eduard Tolosa, Maria Jose Marti, Ruben Fernández-Santiago, Francesc Cardellach, Constanza Morén, Glòria Garrabou
BACKGROUND: Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different experimental models of PD. We aimed to study the role of mitochondria and autophagy in LRRK2 G2019S -mutation, and its relationship with the presence of PD-symptoms. METHODS: Fibroblasts from six non-manifesting LRRK2 G2019S -carriers (NM-LRRK2 G2019S ) and seven patients with LRRK2 G2019S -associated PD (PD-LRRK2 G2019S ) were compared to eight healthy controls (C)...
June 8, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29878202/loss-of-5hmc-identifies-a-new-type-of-aberrant-dna-hypermethylation-in-glioma
#15
Agustin F Fernandez, Gustavo F Bayón, Marta I Sierra, Rocio G Urdinguio, Estela G Toraño, Maria García, Antonella Carella, Virginia Lopez, Pablo Santamarina, Raúl F Pérez, Thalía Belmonte, Juan Ramon Tejedor, Isabel Cobo, Pablo Menendez, Cristina Mangas, Cecilia Ferrero, Luis Rodrigo, Aurora Astudillo, Ignacio Ortea, Sergio Cueto Díaz, Pablo Rodríguez-Gonzalez, J Ignacio García Alonso, Manuela Mollejo, Bárbara Meléndez, Gemma Dominguez, Felix Bonilla, Mario F Fraga
Aberrant DNA hypermethylation is a hallmark of cancer although the underlying molecular mechanisms are still poorly understood. To study the possible role of 5-hydroxymethylcytosine (5hmC) in this process we analyzed the global and locus-specific genome-wide levels of 5hmC and 5mC in human primary samples from 12 non-tumoral brains and 53 gliomas. We found that the levels of 5hmC identified in non-tumoral samples were significantly reduced in gliomas. Strikingly, hypo-hydroxymethylation at 4,627 (9.3%) CpG sites was associated with aberrant DNA hypermethylation and was strongly enriched in CpG island (CGI) shores...
June 5, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29862364/aquaporine-5-and-epithelial-sodium-channel-%C3%AE-subunit-gene-expression-in-gastric-aspirates-in-human-term-newborns
#16
Fabiola Castorena-Torres, Mario René Alcorta-García, Víctor Javier Lara-Díaz
Both transient tachypnea of the newborn and neonatal respiratory distress syndrome have been associated with changes in gene expression of aquaporine-5 (AQP5) and the β subunit of the epithelial sodium channel (β-ENaC) in the respiratory epithelium. Gastric aspirate (GA) obtained immediately after birth could represent a new source for gene expression analysis for these respiratory diseases. The aims of this study were to determine the feasibility of estimating AQP5 and β-ENaC gene expression in exfoliated respiratory epithelial cells from the GA of term neonates, and to compare the values with those found in scraped nasal epithelial cells, previously validated as a surrogate for distal lung epithelium in terms of ionic channel activity...
April 2018: Heliyon
https://www.readbyqxmd.com/read/29859344/autophagy-and-oxidative-stress-in-non-communicable-diseases-a-matter-of-the-inflammatory-state
#17
REVIEW
Daniel Peña-Oyarzun, Roberto Bravo-Sagua, Alexis Diaz, Larissa Aleman, Mario Chiong, Lorena Garcia, Claudia Bambs, Rodrigo Troncoso, Mariana Cifuentes, Eugenia Morselli, Catterina Ferreccio, Andrew F G Quest, Alfredo Criollo, Sergio Lavandero
Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; however they share common features, which are critical for the development of novel therapeutic strategies. A persistently altered inflammatory response is typically observed in many NCDs together with redox imbalance. Additionally, dysregulated proteostasis, mainly derived as a consequence of compromised autophagy, is a common feature of several chronic diseases...
May 30, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29859062/immune-escape-mutations-and-stop-codons-in-hbsag-develop-in-a-large-proportion-of-patients-with-chronic-hbv-infection-exposed-to-anti-hbv-drugs-in-europe
#18
Luna Colagrossi, Lucas E Hermans, Romina Salpini, Domenico Di Carlo, Suzan D Pas, Marta Alvarez, Ziv Ben-Ari, Greet Boland, Bianca Bruzzone, Nicola Coppola, Carole Seguin-Devaux, Tomasz Dyda, Federico Garcia, Rolf Kaiser, Sukran Köse, Henrik Krarup, Ivana Lazarevic, Maja M Lunar, Sarah Maylin, Valeria Micheli, Orna Mor, Simona Paraschiv, Dimitros Paraskevis, Mario Poljak, Elisabeth Puchhammer-Stöckl, François Simon, Maja Stanojevic, Kathrine Stene-Johansen, Nijaz Tihic, Pascale Trimoulet, Jens Verheyen, Adriana Vince, Snjezana Zidovec Lepej, Nina Weis, Tülay Yalcinkaya, Charles A B Boucher, Annemarie M J Wensing, Carlo F Perno, Valentina Svicher
BACKGROUND: HBsAg immune-escape mutations can favor HBV-transmission also in vaccinated individuals, promote immunosuppression-driven HBV-reactivation, and increase fitness of drug-resistant strains. Stop-codons can enhance HBV oncogenic-properties. Furthermore, as a consequence of the overlapping structure of HBV genome, some immune-escape mutations or stop-codons in HBsAg can derive from drug-resistance mutations in RT. This study is aimed at gaining insight in prevalence and characteristics of immune-associated escape mutations, and stop-codons in HBsAg in chronically HBV-infected patients experiencing nucleos(t)ide analogues (NA) in Europe...
June 1, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29858635/correction-to-applicability-and-accuracy-of-pretest-probability-calculations-implemented-in-the-nice-clinical-guideline-for-decision-making-about-imaging-in-patients-with-chest-pain-of-recent-onset
#19
Robert Roehle, Viktoria Wieske, Georg M Schuetz, Pascal Gueret, Daniele Andreini, Willem Bob Meijboom, Gianluca Pontone, Mario Garcia, Hatem Alkadhi, Lily Honoris, Jörg Hausleiter, Nuno Bettencourt, Elke Zimmermann, Sebastian Leschka, Bernhard Gerber, Carlos Rochitte, U Joseph Schoepf, Abbas Arjmand Shabestari, Bjarne Nørgaard, Akira Sato, Juhani Knuuti, Matthijs F L Meijs, Harald Brodoefel, Shona M M Jenkins, Kristian Altern Øvrehus, Axel Cosmus Pyndt Diederichsen, Ashraf Hamdan, Bjørn Arild Halvorsen, Vladimir Mendoza Rodriguez, Yung Liang Wan, Johannes Rixe, Mehraj Sheikh, Christoph Langer, Said Ghostine, Eugenio Martuscelli, Hiroyuki Niinuma, Arthur Scholte, Konstantin Nikolaou, Geir Ulimoen, Zhaoqi Zhang, Hans Mickley, Koen Nieman, Philipp A Kaufmann, Ronny Ralf Buechel, Bernhard A Herzog, Melvin Clouse, David A Halon, Jonathan Leipsic, David Bush, Reda Jakamy, Kai Sun, Lin Yang, Thorsten Johnson, Jean-Pierre Laissy, Roy Marcus, Simone Muraglia, Jean-Claude Tardif, Benjamin Chow, Narinder Paul, David Maintz, John Hoe, Albert de Roos, Robert Haase, Michael Laule, Peter Schlattmann, Marc Dewey
The original version of this article, published on 19 March 2018, unfortunately contained a mistake. The following correction has therefore been made in the original: The names of the authors Philipp A. Kaufmann, Ronny Ralf Buechel and Bernhard A. Herzog were presented incorrectly.
June 1, 2018: European Radiology
https://www.readbyqxmd.com/read/29857915/vitamin-d-supplementation-hypothetical-effect-on-medication-related-osteonecrosis-of-the-jaw
#20
Alejandro I Lorenzo-Pouso, Mario Pérez-Sayáns, Abel García, Javier Carballo
Vitamin D is an important nutrient for bone health and skeleton growth. Few foods are natural sources of this secosteroid; this is the reason why the consumption of vitamin D as a dietary supplement is becoming common in developed countries. For many years vitamin D has been considered crucial in the treatment and prevention of the Global Burden of Disease and in a reduction in mortality among elder people. Many health care providers prescribe these supplements in the management of osteoporosis and metabolic bone diseases; specifically in the primary prevention of fractures...
July 2018: Medical Hypotheses
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