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https://www.readbyqxmd.com/read/28544841/transcatheter-valve-in-valve-implantation-failing-tricuspid-bioprosthesis-in-a-patient-with-ebstein%C3%A2-s-anomaly
#1
Pedro A Villablanca, Aman M Shah, David F Briceno, Ali N Zaidi, Mei Chau, Mario J Garcia, David Slovut, Cynthia Taub
Transcatheter valve-in-valve (VIV) implantation has been recently proposed as an alternative to surgical reoperative aortic valve replacement in patients with a failing aortic bioprosthesis. Experience with transcatheter VIV implantation at other valve positions is very limited. Herein is reported the case of an 18-year-old man with Ebstein's anomaly and severe tricuspid valve (TV) regurgitation status after bioprosthetic valve replacement, who developed new dyspnea on exertion three years after the initial valve replacement...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28538734/zika-virus-evolution-and-spread-in-the-americas
#2
Hayden C Metsky, Christian B Matranga, Shirlee Wohl, Stephen F Schaffner, Catherine A Freije, Sarah M Winnicki, Kendra West, James Qu, Mary Lynn Baniecki, Adrianne Gladden-Young, Aaron E Lin, Christopher H Tomkins-Tinch, Simon H Ye, Daniel J Park, Cynthia Y Luo, Kayla G Barnes, Rickey R Shah, Bridget Chak, Giselle Barbosa-Lima, Edson Delatorre, Yasmine R Vieira, Lauren M Paul, Amanda L Tan, Carolyn M Barcellona, Mario C Porcelli, Chalmers Vasquez, Andrew C Cannons, Marshall R Cone, Kelly N Hogan, Edgar W Kopp, Joshua J Anzinger, Kimberly F Garcia, Leda A Parham, Rosa M Gélvez Ramírez, Maria C Miranda Montoya, Diana P Rojas, Catherine M Brown, Scott Hennigan, Brandon Sabina, Sarah Scotland, Karthik Gangavarapu, Nathan D Grubaugh, Glenn Oliveira, Refugio Robles-Sikisaka, Andrew Rambaut, Lee Gehrke, Sandra Smole, M Elizabeth Halloran, Luis Villar, Salim Mattar, Ivette Lorenzana, Jose Cerbino-Neto, Clarissa Valim, Wim Degrave, Patricia T Bozza, Andreas Gnirke, Kristian G Andersen, Sharon Isern, Scott F Michael, Fernando A Bozza, Thiago M L Souza, Irene Bosch, Nathan L Yozwiak, Bronwyn L MacInnis, Pardis C Sabeti
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States...
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28529508/the-biosynthetic-gene-cluster-for-andrastin-a-in-penicillium-roqueforti
#3
Juan F Rojas-Aedo, Carlos Gil-Durán, Abdiel Del-Cid, Natalia Valdés, Pamela Álamos, Inmaculada Vaca, Ramón O García-Rico, Gloria Levicán, Mario Tello, Renato Chávez
Penicillium roqueforti is a filamentous fungus involved in the ripening of several kinds of blue cheeses. In addition, this fungus produces several secondary metabolites, including the meroterpenoid compound andrastin A, a promising antitumoral compound. However, to date the genomic cluster responsible for the biosynthesis of this compound in P. roqueforti has not been described. In this work, we have sequenced and annotated a genomic region of approximately 29.4 kbp (named the adr gene cluster) that is involved in the biosynthesis of andrastin A in P...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28527676/lactobacillus-salivarius-infection-as-a-postoperative-complication-after-bariatric-surgery
#4
Rafael García Carretero, Marta Regodon Dominguez, Mario Ruiz Bastian, Marta Lopez Lomba
No abstract text is available yet for this article.
May 17, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28527351/permutation-entropy-analysis-of-heart-rate-variability-for-the-assessment-of-cardiovascular-autonomic-neuropathy-in-type-1-diabetes-mellitus
#5
Claudia Carricarte Naranjo, Lazaro M Sanchez-Rodriguez, Marta Brown Martínez, Mario Estévez Báez, Andrés Machado García
Heart rate variability (HRV) analysis is a relevant tool for the diagnosis of cardiovascular autonomic neuropathy (CAN). To our knowledge, no previous investigation on CAN has assessed the complexity of HRV from an ordinal perspective. Therefore, the aim of this work is to explore the potential of permutation entropy (PE) analysis of HRV complexity for the assessment of CAN. For this purpose, we performed a short-term PE analysis of HRV in healthy subjects and type 1 diabetes mellitus patients, including patients with CAN...
May 8, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28508265/incidence-of-vertebral-fractures-in-women-with-systemic-lupus-erythematosus-after-8-years-of-follow-up
#6
Mario García-Carrasco, Claudia Mendoza-Pinto, María de la Luz León-Vázquez, Socorro Méndez-Martínez, Ivet Etchegaray-Morales, Álvaro Montiel-Jarquín, Miguel Angel Enriquez-Guerra, Margarita Muñóz-Guarneros, José Luis Gálvez-Romero, Pamela Soto-Santillán, Ricard Cervera
The aim of this study was to evaluate possible associations between potential risk factors and the occurrence of established vertebral fractures (VF) in Mexican patients with systemic lupus erythematosus (SLE). Consecutive patients with SLE were enrolled in a prospective, observational study from 2006 to 2015. Information on potential risk factors, including demographics, clinical data, and bone mineral density (BMD) at the lumbar spine and hip on dual-energy X-ray absorptiometry was collected at baseline and follow-up...
May 15, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28507799/characterization-of-a-human-anti-tumoral-nk-cell-population-expanded-after-bcg-treatment-of-leukocytes
#7
Eva M García-Cuesta, Gloria Esteso, Omodele Ashiru, Sheila López-Cobo, Mario Álvarez-Maestro, Ana Linares, Mei M Ho, Luis Martínez-Piñeiro, Hugh T Reyburn, Mar Valés-Gómez
Immunotherapy, via intra-vesical instillations of BCG, is the therapy of choice for patients with high-risk non-muscle invasive bladder cancer. The subsequent recruitment of lymphocytes and myeloid cells, as well as the release of cytokines and chemokines, is believed to induce a local immune response that eliminates these tumors, but the detailed mechanisms of action of this therapy are not well understood. Here, we have studied the phenotype and function of the responding lymphocyte populations as well as the spectrum of cytokines and chemokines produced in an in vitro model of human peripheral blood mononuclear cells (PBMCs) co-cultured with BCG...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28506639/increased-c-reactive-protein-plasma-levels-are-not-involved-in-the-onset-of-post-operative-atrial-fibrillation
#8
Andrea Del Campo, Juan Roldán, Hugo E Verdejo, Ricardo Zalaquett, Elia Becerra, Mario Navarro-Marquez, Rosemarie Mellado, Sergio Lavandero, Ramón Corbalán, Lorena García, Mario Chiong
BACKGROUND: Increased inflammation biomarkers plasma levels, including C-reactive protein (CRP), have been associated with the initiation and perpetuation of atrial fibrillation (AF). However, it is not known whether an increased CRP plasma level, without concomitant inflammation, is sufficient to induce AF. We investigated whether higher CRP plasma levels, determined by the presence of +219G>A CRP gene polymorphism, is associated with an increased risk of post-operative AF. METHODS: One hundred and fifteen adult patients submitted to elective coronary surgery were genotyped for the CRP +219G>A polymorphism...
May 12, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28504642/ion-recombination-correction-factor-in-scanned-light-ion-beams-for-absolute-dose-measurement-using-plane-parallel-ionisation-chambers
#9
Severine Rossomme, Julian Horn, Stephan Brons, Oliver Jaekel, Andrea Mairani, Mario Ciocca, Vincent Floquet, Francesco Romano, Diana Rodriguez Garcia, Stefaan Vynckier, Hugo Palmans
Based on international reference dosimetry protocols for light-ion beams, a correction factor (<i>k<sub>s</sub></i>) has to be applied to the response of a plane-parallel ionisation chamber, to account for recombination of negative and positive charges in its air cavity before these charges can be collected on the electrodes. In this work, <i>k<sub>s</sub></i> for IBA PPC40 Roos-type chambers is investigated in four scanned light-ion beams (proton, helium, carbon and oxygen)...
May 15, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28504354/new-methodology-to-reconstruct-in-2-d-the-cuspal-enamel-of-modern-human-lower-molars
#10
Mario Modesto-Mata, Cecilia García-Campos, Laura Martín-Francés, Marina Martínez de Pinillos, Rebeca García-González, Yuliet Quintino, Antoni Canals, Marina Lozano, M Christopher Dean, María Martinón-Torres, José María Bermúdez de Castro
OBJECTIVES: In the last years different methodologies have been developed to reconstruct worn teeth. In this article, we propose a new 2-D methodology to reconstruct the worn enamel of lower molars. Our main goals are to reconstruct molars with a high level of accuracy when measuring relevant histological variables and to validate the methodology calculating the errors associated with the measurements. METHODS: This methodology is based on polynomial regression equations, and has been validated using two different dental variables: cuspal enamel thickness and crown height of the protoconid...
May 15, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28503570/a-frailty-index-from-next-of-kin-data-a-cross-sectional-analysis-from-the-mexican-health-and-aging-study
#11
Mario Ulises Pérez-Zepeda, Matteo Cesari, María Fernanda Carrillo-Vega, Guillermo Salinas-Escudero, Pamela Tella-Vega, Carmen García-Peña
Objectives. To construct a frailty index from next-of-kin information of the last year of life of community-dwelling 50 years old or older adults and test its association with health services utilization. Methods. Cross-sectional analysis from next-of-kin data available from the last wave of the Mexican Health and Aging Study (MHAS). Measurements. Along with descriptive statistics, the frailty index (FI) was tested in regression models to assess its association with adverse outcomes previous to death: number of hospitalized days in the previous year and number of visits to a physician in the previous year, in unadjusted and adjusted models...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28485824/crystal-structure-of-plant-acetohydroxyacid-synthase-the-target-for-several-commercial-herbicides
#12
Mario Daniel Garcia, Jian-Guo Wang, Thierry Lonhienne, Luke William Guddat
Acetohydroxyacid synthase (AHAS, E.C. 2.2.1.6) is the first enzyme in the branched-chain amino acid biosynthesis pathway. Five of the most widely used commercial herbicides (i.e. sulfonylureas, imidazolinones, triazolopyrimidines, pyrimidinyl-benzoates and sulfonylamino-cabonyl-triazolinones) target this enzyme. Here we have determined the first crystal structure of a plantAHAS in the absence of any inhibitor (2.9 Å resolution) and itshows that the herbicide-binding site adopts a folded state even in the absence of an inhibitor...
May 9, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28480434/chemical-characterization-of-a-hypoglycemic-extract-from-cucurbita-ficifolia-bouche-that-induces-liver-glycogen-accumulation-in-diabetic-mice
#13
Garcia Gonzalez Jessica, Garcia Lorenzana Mario, Zamilpa Alejandro, Almanza Perez Julio Cesar, Jasso Villagomez E Ivan, Roman Ramos Ruben, Alarcon-Aguilar Francisco Javier
BACKGROUND: The aqueous extract of Cucurbita ficifolia (C. ficifolia) fruit has demonstrated hypoglycemic effect, which may be attributed to some components in the extract. However, the major secondary metabolites in this fruit have not yet been identified and little is known about its extra-pancreatic action, in particular, on liver carbohydrate metabolism. Therefore, in addition to the isolation and structural elucidation of the principal components in the aqueous extract of C. ficifolia, the aim of this study was to determine whether or not the hypoglycemic effect of the aqueous extract of Cucurbita ficifolia (C...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28479309/-apnoea-in-infants-with-bronchiolitis-incidence-and-risk-factors-for-a-prediction-model
#14
José Miguel Ramos-Fernández, David Moreno-Pérez, Mario Gutiérrez-Bedmar, María Ramírez-Álvarez, Yasmina Martínez García, Lourdes Artacho-González, Antonio Urda-Cardona
INTRODUCTION: The presence of apnoea in acute bronchiolitis (AB) varies between 1.2% and 28.8%, depending on the series, and is one of its most fearsome complications. The aim of this study is to determine the incidence of apnoea in hospitalised patients diagnosed with AB, and to define their associated risk factors in order to construct a prediction model. PATIENTS AND METHOD: A retrospective observational study of patients admitted to a tertiary hospital in the last 5 years with a diagnosis of AB, according to the classic criteria...
May 4, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28473110/impact-of-chronic-total-coronary-occlusion-on-recurrence-of-ventricular-arrhythmias-in-ischemic-secondary-prevention-implantable-cardioverter-defibrillator-recipients-vacto-secondary-study-insights-from-coronary-angiogram-and-electrogram-analysis
#15
Luis Nombela-Franco, Mario Iannaccone, Ignasi Anguera, Ignacio J Amat-Santos, Manuel Sanchez-Garcia, Daniel Bautista, Martin N Calvelo, Andrea Di Marco, Claudio Moretti, Roberto Pozzi, Marco Scaglione, Victoria Cañadas, María Sandin-Fuentes, Angel Arenal, Rodrigo Bagur, Nicasio Perez-Castellano, Cristina Fernandez-Perez, Fiorenzo Gaita, Carlos Macaya, Javier Escaned, Ignacio Fernández-Lozano
OBJECTIVES: This study sought to evaluate the incidence and clinical effect of coronary chronic total occlusions (CTOs) in patients with ischemic cardiomyopathy receiving an implantable cardioverter-defibrillator (ICD) for secondary prevention of sudden cardiac death (SCD). BACKGROUND: CTOs are common in patients with ischemic cardiomyopathy, which is the major cause of SCD. However, the impact of CTO in SCD survivors receiving an ICD is unknown. METHODS: A total of 425 patients who had survived an episode of ventricular arrhythmias and underwent ICD implantation for secondary prevention in 8 centers were included...
May 8, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28471649/three-dimensional-self-organization-in-nanocomposite-layered-systems-by-ultrafast-laser-pulses
#16
Zeming Liu, Jan Siegel, Mario Garcia-Lechuga, Thierry Epicier, Yaya Lefkir, Stéphanie Reynaud, Matthieu Bugnet, Francis Vocanson, Javier Solis, Guy Vitrant, Nathalie Destouches
Controlling plasmonic systems with nanometer resolution in transparent films and their colors over large nonplanar areas is a key issue for spreading their use in various industrial fields. Using light to direct self-organization mechanisms provides high-speed and flexible processes to meet this challenge. Here, we describe a route for the laser-induced self-organization of metallic nanostructures in 3D. Going beyond the production of planar nanopatterns, we demonstrate that ultrafast laser-induced excitation combined with nonlinear feedback mechanisms in a nanocomposite thin film can lead to 3D self-organized nanostructured films...
May 9, 2017: ACS Nano
https://www.readbyqxmd.com/read/28469492/diagnostic-strategies-for-early-recognition-of-cancer-therapeutics-related-cardiac-dysfunction
#17
REVIEW
Carlos R Manrique, Michael Park, Nidhish Tiwari, Juan Carlos Plana, Mario J Garcia
Cardiovascular toxicity in the form of cardiac dysfunction continues to be an obstacle for patients with cancer. Survival and quality of life of cancer survivors are frequently affected by increased incidence of cardiovascular disease. The involvement of the cardiovascular system by primary or secondary malignancies, as well as its dysfunction secondary to the administration of antineoplastics, has led to the development of a new discipline called Cardio-Oncology, an exciting cardiology subspecialty with more questions than answers and as a result an enormous opportunity for research in the field...
2017: Clinical Medicine Insights. Cardiology
https://www.readbyqxmd.com/read/28464893/anticancer-potential-of-thevetia-peruviana-fruit-methanolic-extract
#18
Alberto Ramos-Silva, Faviola Tavares-Carreón, Mario Figueroa, Susana De la Torre-Zavala, Argel Gastelum-Arellanez, Aída Rodríguez-García, Luis J Galán-Wong, Hamlet Avilés-Arnaut
BACKGROUND: Thevetia peruviana (Pers.) K. Schum or Cascabela peruviana (L.) Lippold (commonly known as ayoyote, codo de fraile, lucky nut, or yellow oleander), native to Mexico and Central America, is a medicinal plant used traditionally to cure diseases like ulcers, scabies, hemorrhoids and dissolve tumors. The purpose of this study was to evaluate the cytotoxic, antiproliferative and apoptotic activity of methanolic extract of T. peruviana fruits on human cancer cell lines. METHODS: The cytotoxic activity of T...
May 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28453476/reduced-cerebral-blood-flow-in-mild-cognitive-impairment-assessed-using-phase-contrast-mri
#19
Reyes García de Eulate, Irene Goñi, Alvaro Galiano, Marta Vidorreta, Miriam Recio, Mario Riverol, José L Zubieta, María A Fernández-Seara
There is increasing evidence of a vascular contribution to Alzheimer's disease (AD). In some cases, prior work suggests that chronic brain hypoperfusion could play a prime pathogenic role contributing to the accumulation of amyloid-β,while other studies favor the hypothesis that vascular dysfunction and amyloid pathology are independent, although synergistic, mechanisms contributing to cognitive impairment. Vascular dysfunction can be evaluated by assessing cerebral blood flow impairment. Phase contrast velocity mapping by MRI offers a non-invasive means of quantifying the total inflow of blood to the brain...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28451809/microbial-amensalism-in-lactobacillus-casei-and-pseudomonas-taetrolens-mixed-culture
#20
Cristina García, Manuel Rendueles, Mario Díaz
Pseudomonas taetrolens has recently been revealed as an effective microbial producer of lactobionic acid from carbohydrates contained in dairy byproducts. In terms of food industrial applications, the implementation of lactobionic acid biosynthesis coupled with the classic bacterial production of lactic acid appears an important goal. This research paper studies the simultaneous fermentation of residual cheese whey by P. taetrolens and Lactobacillus casei to co-produce lactic and lactobionic acids. Experimental data showed the importance of the interactions established between the two microorganisms...
April 27, 2017: Bioprocess and Biosystems Engineering
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