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https://www.readbyqxmd.com/read/28108197/identification-of-aminopeptidase-n2-as-a-cry2ab-binding-protein-in-manduca-sexta
#1
Janette Onofre, Meztlli O Gaytán, Arlen Peña-Cardeña, Blanca I García-Gomez, Sabino Pacheco, Isabel Gómez, Alejandra Bravo, Mario Soberón
Bacillus thuringiensis Cry2Ab toxin has been used in combination with Cry1Ac for resistance management on the Bt-cotton that is widely planted worldwide. However, little is known regarding Cry2Ab mode of action. Particularly, there is a gap of knowledge on the identification of insect midgut proteins that bind Cry2Ab and mediate toxicity. In the case of Cry1Ab toxin, a transmembrane cadherin protein and glycosyl-phosphatidylinositol (GPI) anchored proteins like aminopeptidase-N1 (APN1) or alkaline-phosphatase (ALP) from Manduca sexta, have been shown to be important for oligomer formation and insertion into the membrane...
January 17, 2017: Peptides
https://www.readbyqxmd.com/read/28106247/validation-of-the-nccn-ipi-for-diffuse-large-b-cell-lymphoma-dlbcl-the-addition-of-%C3%AE-2-microglobulin-yields-a-more-accurate-geltamo-ipi
#2
Carlos Montalbán, Antonio Díaz-López, Ivan Dlouhy, Jordina Rovira, Armando Lopez-Guillermo, Sara Alonso, Alejandro Martín, Juan M Sancho, Olga García, Jose M Sánchez, Mario Rodríguez, Silvana Novelli, Antonio Salar, Antonio Gutiérrez, Maria J Rodríguez-Salazar, Mariana Bastos, Juan F Domínguez, Rubén Fernández, Sonia Gonzalez de Villambrosia, José A Queizan, Raul Córdoba, Raquel de Oña, Andrés López-Hernandez, Julian M Freue, Heidys Garrote, Lourdes López, Ana M Martin-Moreno, Jose Rodriguez, Víctor Abraira, Juan F García
The study included 1848 diffuse large B-cell lymphoma (DLBCL)patients treated with chemotherapy/rituximab. The aims were to validate the National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI) and explore the effect of adding high Beta-2 microglobulin (β2M), primary extranodal presentation and intense treatment to the NCCN-IPI variables in order to develop an improved index. Comparing survival curves, NCCN-IPI discriminated better than IPI, separating four risk groups with 5-year overall survival rates of 93%, 83%, 67% and 49%, but failing to identify a true high-risk population...
January 20, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28100251/consensus-guideline-for-the-diagnosis-and-treatment-of-aromatic-l-amino-acid-decarboxylase-aadc-deficiency
#3
REVIEW
Tessa Wassenberg, Marta Molero-Luis, Kathrin Jeltsch, Georg F Hoffmann, Birgit Assmann, Nenad Blau, Angeles Garcia-Cazorla, Rafael Artuch, Roser Pons, Toni S Pearson, Vincenco Leuzzi, Mario Mastrangelo, Phillip L Pearl, Wang Tso Lee, Manju A Kurian, Simon Heales, Lisa Flint, Marcel Verbeek, Michèl Willemsen, Thomas Opladen
Aromatic L-amino acid decarboxylase deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder that leads to a severe combined deficiency of serotonin, dopamine, norepinephrine and epinephrine. Onset is early in life, and key clinical symptoms are hypotonia, movement disorders (oculogyric crisis, dystonia, and hypokinesia), developmental delay, and autonomic symptoms.In this consensus guideline, representatives of the International Working Group on Neurotransmitter Related Disorders (iNTD) and patient representatives evaluated all available evidence for diagnosis and treatment of AADCD and made recommendations using SIGN and GRADE methodology...
January 18, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28092253/-mexican-treatment-goals-for-plaque-psoriasis
#4
Lorena Estrada-Aguilar, Mario Amaya-Guerra, Minerva Gómez-Flores, Esther Guevara-Sanginés, Fermín Jurado-Santacruz, Adriana Lopeztello-Santillán, César Maldonado-García, Mónica Rivera-Gómez, Norma Rodríguez-Martínez, Luis Vega-González
Psoriasis is a chronic inflammatory disease with a worldwide prevalence between 6 and 39% in moderate to severe forms. In European countries like Germany and England was identified that only one third of patients with moderate to severe forms will receive systemic management, this fact motivated to integrate into Europe an international consensus on treatment goals with the aim of providing support to the dermatologist by algorithms that serve as a therapeutic guide that allows you to gain control short and long term effects of this disease...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28089361/solitary-fibrous-tumor-of-the-gastroesophageal-junction
#5
Katherine T Plúa Muñiz, Raúl Otero Russel, Rosalía Velasco López, Mario Rodríguez López, José María García-Abril Alonso
No abstract text is available yet for this article.
January 11, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28087193/immunohistochemical-study-of-metallothionein-in-patients-with-temporal-lobe-epilepsy
#6
Daniel Juárez-Rebollar, Mario Alonso-Vanegas, Concepción Nava-Ruíz, Masao Buentello-García, Petra Yescas-Gómez, Araceli Díaz-Ruíz, Camilo Rios, Marisela Méndez-Armenta
Epilepsy is characterized by spontaneous recurrent seizures and temporal lobe epilepsy (TLE) is the most common serious neurological example of acquired and frequent epilepsy. Oxidative stress is recognized as playing a contributing role in several neurological disorders, and most recently have been implicated in acquired epilepsies. The MTs occur in several brain regions and may serve as neuroprotective proteins against reactive oxygen species causing oxidative damage and stress. The main aim of this work was to describe the immunohistochemical localization of MT in the specimens derived from the patients affected by TLE...
January 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28076583/-social-factors-associated-with-use-of-prenatal-care-in-ecuador
#7
Amaya Sánchez-Gómez, William Cevallos, Mario J Grijalva, Luis C Silva-Ayçaguer, Susana Tamayo, Jerry O Jacobson, Jaime A Costales, Rodrigo Jiménez-Garcia, Valentín Hernández-Barrera, Suzanne Serruya, Celia Riera
Objectives: Prenatal care is a pillar of public health, enabling access to interventions including prevention of mother-to-child transmission of HIV and congenital syphilis. This paper describes social factors related to use of prenatal care in Ecuador. Methods: In 2011 and 2012, participant clinical history and interview information was analyzed from a national probability sample of 5 998 women presenting for delivery or miscarriage services in 15 healthcare facilities in Ecuador, to estimate prevalence of HIV, syphilis, and Chagas disease, and prenatal care coverage...
November 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28075589/water-soluble-ruthenium-ii-chiral-heteroleptic-complexes-with-amoebicidal-in-vitro-and-in-vivo-activity
#8
Yanis Toledano-Magaña, Juan Carlos García-Ramos, Carolina Torres-Gutiérrez, Cristina Vázquez-Gasser, José Manuel Esquivel-Sánchez, Marcos Flores-Alamo, Luis Ortiz-Frade, Rodrigo Galindo-Murillo, Mario Nequiz, Marco Gudiño-Zayas, Juan Pedro Laclette, Julio César Carrero, Lena Ruiz-Azuara
Three novel water soluble Ru(II) chiral heteroleptic coordination compounds [Ru(en)(pdto)]Cl2 (1), [Ru(gly)(pdto)]Cl (2) and [Ru(acac)(pdto)]Cl (3) where pdto= 1,8-bis-(2-pyridyl)-3,6-dithioctane, en= ethylendiamine, gly= glycinate and acac= acetylacetonate have been synthesised and have shown remarkable amoebicidal activity in vitro and in vivo. The crystal structures of compounds 1-3 are described. The in vitro IC50 values found are within nanomolar range (0.14, 0.12 and 0.06 µM for compounds 1, 2 and 3, respectively)...
January 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28056794/mercury-exposure-and-risk-of-cardiovascular-disease-a-nested-case-control-study-in-the-predimed-prevention-with-mediterranean-diet-study
#9
Mary K Downer, Miguel A Martínez-González, Alfredo Gea, Meir Stampfer, Julia Warnberg, Miguel Ruiz-Canela, Jordi Salas-Salvadó, Dolores Corella, Emilio Ros, Montse Fitó, Ramon Estruch, Fernando Arós, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Monica Bullo, Jose V Sorli, Miguel A Muñoz, Antonio García-Rodriguez, Mario Gutierrez-Bedmar, Enrique Gómez-Gracia
BACKGROUND: Substantial evidence suggests that consuming 1-2 servings of fish per week, particularly oily fish (e.g., salmon, herring, sardines) is beneficial for cardiovascular health due to its high n-3 polyunsaturated fatty acid content. However, there is some concern that the mercury content in fish may increase cardiovascular disease risk, but this relationship remains unclear. METHODS: The PREDIMED trial included 7477 participants who were at high risk for cardiovascular disease at baseline...
January 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28056107/autophagy-is-an-innate-mechanism-associated-with-leprosy-polarization
#10
Bruno Jorge de Andrade Silva, Mayara Garcia de Mattos Barbosa, Priscila Ribeiro Andrade, Helen Ferreira, José Augusto da Costa Nery, Suzana Côrte-Real, Gilberto Marcelo Sperandio da Silva, Patricia Sammarco Rosa, Mario Fabri, Euzenir Nunes Sarno, Roberta Olmo Pinheiro
Leprosy is a chronic infectious disease that may present different clinical forms according to the immune response of the host. Levels of IFN-γ are significantly raised in paucibacillary tuberculoid (T-lep) when compared with multibacillary lepromatous (L-lep) patients. IFN-γ primes macrophages for inflammatory activation and induces the autophagy antimicrobial mechanism. The involvement of autophagy in the immune response against Mycobacterium leprae remains unexplored. Here, we demonstrated by different autophagic assays that LC3-positive autophagosomes were predominantly observed in T-lep when compared with L-lep lesions and skin-derived macrophages...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28033306/outcomes-of-%C3%A2-6-month-versus-12-month-dual-antiplatelet-therapy-after-drug-eluting-stent-implantation-a-meta-analysis-and-meta-regression
#11
Pedro A Villablanca, Daniele Massera, Verghese Mathew, Sripal Bangalore, Panagiota Christia, Irving Perez, Ningxin Wan, Stefanie Schulz-Schüpke, David F Briceno, Anna E Bortnick, Mario J Garcia, Richard Lucariello, Mark Menegus, Robert Pyo, Jose Wiley, Harish Ramakrishna
BACKGROUND: The benefit of ≤6-month compared with 12-month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) with drug-eluting stent (DES) placement remains controversial. We performed a meta-analysis and meta-regression of ≤6-month versus 12-month DAPT in patients undergoing PCI with DES placement. METHODS: We conducted electronic database searches of randomized controlled trials (RCTs) comparing DAPT durations after DES placement...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28030792/genomic-expression-differences-between-cutaneous-cells-from-red-hair-color-individuals-and-black-hair-color-individuals-based-on-bioinformatic-analysis
#12
Joan Anton Puig-Butille, Pol Gimenez-Xavier, Alessia Visconti, Jérémie Nsengimana, Francisco Garcia-García, Gemma Tell-Marti, Maria José Escamez, Julia Newton-Bishop, Veronique Bataille, Marcela Del Río, Joaquín Dopazo, Mario Falchi, Susana Puig
The MC1R gene plays a crucial role in pigmentation synthesis. Loss-of-function MC1R variants, which impair protein function, are associated with red hair color (RHC) phenotype and increased skin cancer risk. Cultured cutaneous cells bearing loss-of-function MC1R variants show a distinct gene expression profile compared to wild-type MC1R cultured cutaneous cells. We analysed the gene signature associated with RHC co-cultured melanocytes and keratinocytes by Protein-Protein interaction (PPI) network analysis to identify genes related with non-functional MC1R variants...
December 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28028727/vitamin-d-deficiency-in-older-adults-and-its-associated-factors-a-cross-sectional-analysis-of-the-mexican-health-and-aging-study
#13
María Fernanda Carrillo-Vega, Carmen García-Peña, Luis Miguel Gutiérrez-Robledo, Mario Ulises Pérez-Zepeda
: Vitamin D deficiency was common in older adults from a country with adequate sun exposure. The variables associated with this deficiency provide insight into the next steps needed to characterize older adults with this deficiency and to treat it accordingly. PURPOSE: The aim of this study was to describe the prevalence of and factors associated with vitamin D deficiency among Mexican older adults. METHODS: This was a secondary analysis of the last wave of the Mexican Health and Aging Study...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28018289/choroidal-and-retinal-abnormalities-by-optical-coherence-tomography-in-endogenous-cushing-s-syndrome
#14
Maria Fernanda Abalem, Marcio Carlos Machado, Helen Nazareth Veloso Dos Santos, Rafael Garcia, John Helal, Pedro Carlos Carricondo, Sérgio Luis Gianotti Pimentel, Mario Luiz Ribeiro Monteiro, Cynthia X Qian, Marcello Delano Bronstein, Maria Cândida Villares Barisson Fragoso
CONTEXT: Cortisol has been suggested as a risk factor for choroidal thickening, which may lead to retinal changes. OBJECTIVE: To compare choroidal thickness measurements using optical coherence tomography (OCT) in patients with endogenous active Cushing's syndrome (CS) and to evaluate the occurrence of retinal abnormalities in the same group of patients. DESIGN: Cross-sectional study. SETTING: Outpatient clinic. PATIENTS: Eleven female patients with CS in hypercortisolism state as determined by the presence of at least two abnormal measurements from urinary cortisol 24 h, no suppression of cortisol with low dose dexamethasone suppression test, and nocturnal salivary cortisol levels and 12 healthy controls...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28017900/the-95-%C3%AE-g-mutation-in-the-5-untranslated-region-of-the-nora-gene-increases-efflux-activity-in-staphylococcus-epidermidis-isolates
#15
Elizabeth García-Gómez, Marcos E Jaso-Vera, Marco A Juárez-Verdayes, María D Alcántar-Curiel, Juan C Zenteno, Gabriel Betanzos-Cabrera, Humberto Peralta, Sandra Rodríguez-Martínez, Mario E Cancino-Díaz, Janet Jan-Roblero, Juan C Cancino-Diaz
In the Staphylococcus aureus ATCC25923 strain, the flqB mutation in the 5'untranslated region (5'UTR) of the norA gene causes increased norA mRNA expression and high efflux activity (HEA). The involvement of the norA gene 5'UTR in HEA has not been explored in S. epidermidis; therefore, we examined the function of this region in S. epidermidis clinical isolates. The selection of isolates with HEA was performed based on ethidium bromide (EtBr) MIC values and efflux efficiency (EF) using the semi-automated fluorometric method...
December 23, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28017687/further-psychometric-validation-of-the-gah-scale-responsiveness-and-effect-size
#16
Alfonso José Cruz-Jentoft, Bernardo González, Javier de la Rubia, José Ángel Hernández Rivas, Juan Alfonso Soler, Carlos Fernández Lago, Mario Arnao, Mercedes Gironella, Ernesto Pérez Persona, María Teresa Zudaire, Carmen Olivier, Alberto Altés, Antonio García Guiñón, Benet Nomdedeu, Montserrat Arnan, Ángel Ramírez Payer, Pedro Sánchez-Godoy, Nuria Pajuelo, David Vilanova, Diego Fernánez Monjil, Santiago Bonanad
OBJECTIVES: The purpose of this study was to assess the responsiveness of the newly developed Geriatric Assessment in Hematology (GAH) scale to clinical change in older patients diagnosed with hematologic malignancies. METHODS: A prospective observational study conducted in 164 patients aged ≥65years and diagnosed with myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML), multiple myeloma (MM), or chronic lymphocytic leukemia (CLL). Responsiveness of the GAH scales was studied by means of the Eastern Cooperative Oncology Group (ECOG) score, the Karnofsky performance status (KPS) score, the visual analog scale (VAS), and the physician's subjective assessment, used as clinical anchors to identify whether patients had changed clinically (either improved or worsened) or not since the baseline visit...
December 22, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28002967/discovery-of-1s-2r-3s-4s-5r-6r-2-amino-3-3-4-difluorophenyl-sulfanylmethyl-4-hydroxy-bicyclo-3-1-0-hexane-2-6-dicarboxylic-acid-hydrochloride-ly3020371%C3%A2-hcl-a-potent-metabotropic-glutamate-2-3-receptor-antagonist-with-antidepressant-like-activity
#17
Mark D Chappell, Renhua Li, Stephon C Smith, Bruce A Dressman, Eric G Tromiczak, Allie E Tripp, Maria-Jesus Blanco, Tatiana Vetman, Steven J Quimby, James Matt, Thomas C Britton, Adam M Fivush, Jeffrey M Schkeryantz, Daniel Mayhugh, Jon A Erickson, Mark G Bures, Carlos Jaramillo, Mercedes Carpintero, José Eugenio de Diego, Mario Barberis, Susana Garcia-Cerrada, José F Soriano, Stephen Antonysamy, Shane Atwell, Iain MacEwan, Bradley Condon, Christine Sougias, Jing Wang, Aiping Zhang, Kris Conners, Chris Groshong, Stephen R Wasserman, John W Koss, Jeffrey M Witkin, Xia Li, Carl Overshiner, Keith A Wafford, Wesley Seidel, Xu-Shan Wang, Beverly A Heinz, Steven Swanson, John T Catlow, David W Bedwell, James A Monn, Charles H Mitch, Paul L Ornstein
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid scaffold to generate mGlu2/3 antagonists. Exploration of this structure-activity relationship (SAR) led to the identification of (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride (LY3020371·HCl, 19f), a potent, selective, and maximally efficacious mGlu2/3 antagonist...
December 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28002502/ehnpc1-and-ehnpc2-proteins-participate-in-trafficking-of-exogenous-cholesterol-in-entamoeba-histolytica-trophozoites-relevance-for-phagocytosis
#18
Jeni Bolaños, Abigail Betanzos, Rosario Javier-Reyna, Guillermina García-Rivera, Miriam Huerta, Jonnatan Pais-Morales, Arturo González-Robles, Mario A Rodríguez, Michael Schnoor, Esther Orozco
Entamoeba histolytica, the highly phagocytic protozoan causative of human amoebiasis lacks the machinery to synthesize cholesterol. Here, we investigated the presence of NPC1 and NPC2 proteins in this parasite, which are involved in cholesterol trafficking in mammals. Bioinformatics analysis revealed one Ehnpc1 and two Ehnpc2 genes. EhNPC1 appeared as a transmembrane protein and both EhNPC2 as peripheral membrane proteins. Molecular docking predicted that EhNPC1 and EhNPC2 bind cholesterol and interact with each other...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27999307/autonomous-aeromagnetic-surveys-using-a-fluxgate-magnetometer
#19
Douglas G Macharet, Héctor I A Perez-Imaz, Paulo A F Rezeck, Guilherme A Potje, Luiz C C Benyosef, André Wiermann, Gustavo M Freitas, Luis G U Garcia, Mario F M Campos
Recent advances in the research of autonomous vehicles have showed a vast range of applications, such as exploration, surveillance and environmental monitoring. Considering the mining industry, it is possible to use such vehicles in the prospection of minerals of commercial interest beneath the ground. However, tasks such as geophysical surveys are highly dependent on specific sensors, which mostly are not designed to be used in these new range of autonomous vehicles. In this work, we propose a novel magnetic survey pipeline that aims to increase versatility, speed and robustness by using autonomous rotary-wing Unmanned Aerial Vehicles (UAVs)...
December 17, 2016: Sensors
https://www.readbyqxmd.com/read/27992035/speckle-tracking-and-transthyretin-amyloid-cardiomyopathy
#20
Alexandre Marins Rocha, Suzane Garcia Ferreira, Marcelo Souto Nacif, Mario Luiz Ribeiro, Marcos Raimundo Gomes de Freitas, Cláudio Tinoco Mesquita
Background: Amyloidosis is a disease caused by deposits of insoluble fibrils in extracellular spaces. The most common type of familial amyloidosis is mediated by mutation of transthyretin, especially Val30Met. Symptoms and ejection fraction decrease may occur in cardiac amyloidosis only in case of poor prognosis. Myocardial strain detected by two-dimensional speckle tracking echocardiography can indicate changes in myocardial function at early stages of the disease. Objective: To determine the accuracy of left ventricular longitudinal strain by two-dimensional speckle tracking echocardiography in patients with familial amyloidosis caused by Val30Met transthyretin mutation...
December 19, 2016: Arquivos Brasileiros de Cardiologia
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