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https://www.readbyqxmd.com/read/29440497/structural-insights-into-the-mechanism-of-inhibition-of-ahas-by-herbicides
#1
Thierry Lonhienne, Mario D Garcia, Gregory Pierens, Mehdi Mobli, Amanda Nouwens, Luke W Guddat
Acetohydroxyacid synthase (AHAS), the first enzyme in the branched amino acid biosynthesis pathway, is present only in plants and microorganisms, and it is the target of >50 commercial herbicides. Penoxsulam (PS), which is a highly effective broad-spectrum AHAS-inhibiting herbicide, is used extensively to control weed growth in rice crops. However, the molecular basis for its inhibition of AHAS is poorly understood. This is despite the availability of structural data for all other classes of AHAS-inhibiting herbicides...
February 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29433260/hydroxytyrosol-bioavailability-toxicity-and-clinical-applications
#2
REVIEW
María Robles-Almazan, Mario Pulido-Moran, Jorge Moreno-Fernandez, Cesar Ramirez-Tortosa, Carmen Rodriguez-Garcia, Jose L Quiles, MCarmen Ramirez-Tortosa
Many beneficial properties have been attributed to the Mediterranean diet. Over the years, researchers have attempted to learn which foods and which food components are responsible for good health. One of these components is hydroxytyrosol, an important phenolic compound present in olive oil. Hydroxytyrosol is a molecule of high interest to the pharmaceutical industry due to its anti-inflammatory and antimicrobial qualities its role against cardiovascular diseases and metabolic syndrome and for its neuroprotection, antitumour, and chemo modulation effects...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29429029/very-high-frequency-oscillations-of-heart-rate-variability-in-healthy-humans-and-in-patients-with-cardiovascular-autonomic-neuropathy
#3
Mario Estévez-Báez, Calixto Machado, Julio Montes-Brown, Javier Jas-García, Gerry Leisman, Adam Schiavi, Andrés Machado-García, Claudia Carricarte-Naranjo, Eli Carmeli
Literature reports on the very high frequency (VHF) range of 0.4-0.9 Hz in heart rate variability (HRV) are scanty. The VHF presence in cardiac transplant patients and other conditions associated with reduced vagal influence on the heart encouraged us to explore this spectral band in healthy subjects and in patients diagnosed with cardiac autonomic neuropathy (CAN), and to assess the potential clinical value of some VHF indices. The study included 80 healthy controls and 48 patients with spinocerebellar ataxia type 2 (SCA2) with CAN...
February 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29420529/genes-del-receptor-variable-beta-de-c%C3%A3-lulas-t-en-c%C3%A3-lulas-circulantes-de-pacientes-con-lupus-eritematoso-generalizado-y-sus-familiares-sanos
#4
Juan Jakez-Ocampo, Carmen María Paulín-Vera, Liliana Rivadeneyra-Espinoza, Diana Gómez-Martín, Eduardo Carrillo-Maravilla, Guadalupe Lima, María Inés Vargas-Rojas, Beatriz Pérez-Romano, Gabriella Calva-Cevenini, Mario García-Carrasco, Alejandro Ruiz-Argüelles, Luis Llorente
Objetivo: Se investigó la proporción de la expresión génica del receptor variable beta de células T (Vβ TCR) en linfocitos periféricos CD3+ en pacientes con lupus eritematoso generalizado (LEG) familiar y no familiar. Método: El repertorio de Vβ TCR se estudió en 14 familias que presentaban más de un miembro con LEG. El uso de Vβ TCR en pacientes con LEG (n = 27) se comparó con el de los miembros sanos de estas familias (n = 47), con 37 pacientes con LEG esporádico y con 15 controles sanos...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29408797/effect-of-cilostazol-on-platelet-reactivity-among-patients-with-peripheral-artery-disease-on-clopidogrel-therapy
#5
Dagmar F Hernandez-Suarez, Hector Núñez-Medina, Stuart A Scott, Angel Lopez-Candales, Jose M Wiley, Mario J Garcia, Kyle Melin, Karid Nieves-Borrero, Christina Rodriguez-Ruiz, Lorraine Marshall, Jorge Duconge
BACKGROUND: Antiplatelet therapy with clopidogrel is recommended to reduce cardiovascular events in patients with peripheral artery disease (PAD); however, clopidogrel efficacy has not been adequately studied in this patient population. Therefore, we aimed to determine the effects of cilostazol therapy on platelet reactivity among PAD patients on clopidogrel. METHODS: We performed a cross-sectional pilot study of 46 Puerto Rican patients diagnosed with PAD. The cohort was divided based on use of clopidogrel and cilostazol (n=24) or clopidogrel alone (n=22)...
February 6, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29407840/iron-oxide-clay-composite-vectors-on-long-distance-transport-of-arsenic-and-toxic-metals-in-mining-affected-areas
#6
Miguel A Gomez-Gonzalez, Mario Villalobos, Jose Francisco Marco, Javier Garcia-Guinea, Eduardo Bolea, Francisco Laborda, Fernando Garrido
Mine wastes from abandoned exploitations are sources of high concentrations of hazardous metal(oid)s. Although these contaminants can be attenuated by sorbing to secondary minerals, in this work we identified a mechanism for long-distance dispersion of arsenic and metals through their association to mobile colloids. We characterize the colloids and their sorbed contaminants using spectrometric and physicochemical fractionation techniques. Mechanical action through erosion may release and transport high concentrations of colloid-associated metal(oid)s towards nearby stream waters, promoting their dispersion from the contamination source...
January 27, 2018: Chemosphere
https://www.readbyqxmd.com/read/29399923/catheter-ablation-of-ventricular-tachycardia-in-non-ischemic-cardiomyopathy-a-propensity-score-matched-analysis-of-in-hospital-outcomes-in-the-united-states
#7
David F Briceño, Tanush Gupta, Jorge Romero, Dhaval Kolte, Sahil Khera, Pedro A Villablanca, An Tran, Sanghamitra Mohanty, Chintan Trivedi, Prasant Mohanty, Carola Gianni, Soo G Kim, Mario Garcia, Gregg C Fonarow, Deepak L Bhatt, Andrea Natale, Luigi Di Biase
INTRODUCTION: Monomorphic ventricular tachycardia (VT) is an important cause of morbidity and mortality. Use and outcome data of catheter ablation for VT in non-ischemic cardiomyopathy (NICM) are limited. METHODS AND RESULTS: We obtained data from the 2003-2014 National Inpatient Sample databases. We used propensity score matching to compare patients undergoing catheter ablation versus medical therapy of VT related to NICM, and described the temporal trends in utilization and in-hospital outcomes of catheter ablation of VT in patients with NICM in the United States...
February 5, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29399876/extracellular-proteases-of-staphylococcus-epidermidis-roles-as-virulence-factors-and-their-participation-in-biofilm
#8
REVIEW
Sergio Martínez-García, Sandra Rodríguez-Martínez, Mario E Cancino-Diaz, Juan C Cancino-Diaz
Staphylococci produce a large number of extracellular proteases, some of which are considered as potential virulence factors. Staphylococcus epidermidis is a causative agent of nosocomial infections in medical devices by the formation of biofilms. It has been proposed that proteases contribute to the different stages of biofilm formation. S. epidermidis secretes a small number of extracellular proteases, such as serine protease Esp, cysteine protease EcpA, and metalloprotease SepA that have a relatively low substrate specificity...
February 5, 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29396687/efficacy-and-safety-of-pop-titrated-versus-fixed-energy-trans-scleral-diode-laser-cyclophotocoagulation-for-refractory-glaucoma
#9
Marcelo O Stevenson-Fernandez, Alejandro Rodriguez-Garcia, Angelina Espino-Barros Palau, Pedro Mario Gonzalez-Madrigal
PURPOSE: To compare the efficacy and safety of pop-titrated versus fixed-energy diode laser trans-scleral cyclophotocoagulation (DLTSC) for refractory glaucoma. METHODS: This is a prospective, interventional, longitudinal, and comparative case-control study. Patients with refractory glaucoma treated with pop-titrated DLTSC were compared to a fixed-energy DLTSC control group. Variables analyzed included: age, gender, diagnosis, pre- and post-treatment intraocular pressure (IOP)...
February 2, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29385678/efficient-oleds-fabricated-by-solution-process-based-on-carbazole-and-thienopyrrolediones-derivatives
#10
Luis-Abraham Lozano-Hernández, José-Luis Maldonado, Cesar Garcias-Morales, Arian Espinosa Roa, Oracio Barbosa-García, Mario Rodríguez, Enrique Pérez-Gutiérrez
Four low molecular weight compounds-three of them new, two of them with carbazole (Cz) as functional group and the other two with thienopyrroledione (TPD) group-were used as emitting materials in organic light emitting diodes (OLEDs). Devices were fabricated with the configuration ITO/PEDOT:PSS/emitting material/LiF/Al. The hole injector layer (HIL) and the emitting sheet were deposited by spin coating; LiF and Al were thermally evaporated. OLEDs based on carbazole derivatives show luminances up to 4130 cd/m², large current efficiencies about 20 cd/A and, cautiously, a very impressive External Quantum Efficiency (EQE) up to 9...
January 30, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29384722/chemohormonal-therapy-in-metastatic-hormone-sensitive-prostate-cancer-long-term-survival-analysis-of-the-randomized-phase-iii-e3805-chaarted-trial
#11
Christos E Kyriakopoulos, Yu-Hui Chen, Michael A Carducci, Glenn Liu, David F Jarrard, Noah M Hahn, Daniel H Shevrin, Robert Dreicer, Maha Hussain, Mario Eisenberger, Manish Kohli, Elizabeth R Plimack, Nicholas J Vogelzang, Joel Picus, Matthew M Cooney, Jorge A Garcia, Robert S DiPaola, Christopher J Sweeney
Purpose Docetaxel added to androgen-deprivation therapy (ADT) significantly increases the longevity of some patients with metastatic hormone-sensitive prostate cancer. Herein, we present the outcomes of the CHAARTED (Chemohormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer) trial with more mature follow-up and focus on tumor volume. Patients and Methods In this phase III study, 790 patients with metastatic hormone-sensitive prostate cancer were equally randomly assigned to receive either ADT in combination with docetaxel 75 mg/m2 for up to six cycles or ADT alone...
January 31, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29378312/under-dilated-tips-associate-with-efficacy-and-reduced-encephalopathy-in-a-prospective-non-randomized-study-of-patients-with-cirrhosis
#12
Filippo Schepis, Francesco Vizzutti, Guadalupe Garcia-Tsao, Guido Marzocchi, Luigi Rega, Nicola De Maria, Tommaso Di Maira, Stefano Gitto, Cristian Caporali, Stefano Colopi, Mario De Santis, Umberto Arena, Antonio Rampoldi, Aldo Airoldi, Alessandro Cannavale, Fabrizio Fanelli, Cristina Mosconi, Matteo Renzulli, Roberto Agazzi, Roberto Nani, Pietro Quaretti, Ilaria Fiorina, Lorenzo Moramarco, Roberto Miraglia, Angelo Luca, Raffaele Bruno, Stefano Fagiuoli, Rita Golfieri, Pietro Torricelli, Fabrizio Di Benedetto, Luca Saverio Belli, Federico Banchelli, Giacomo Laffi, Fabio Marra, Erica Villa
BACKGROUND & AIMS: Portosystemic encephalopathy (PSE) is a major complication of trans-jugular intrahepatic porto-systemic shunt (TIPS) placement. Most devices are self-expandable polytetrafluoroethylene-covered stent grafts (PTFE-SGs) that are dilated to their nominal diameter (8 or 10 mm). We investigated whether PTFE-SGs dilated to a smaller caliber (under-dilated TIPS) reduce PSE yet maintain clinical and hemodynamic efficacy. We also studied whether under-dilated TIPS self-expand to nominal diameter over time...
January 25, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29377961/shared-and-organism-specific-host-responses-to-childhood-diarrheal-diseases-revealed-by-whole-blood-transcript-profiling
#13
Hannah A DeBerg, Mussaret B Zaidi, Matthew C Altman, Prasong Khaenam, Vivian H Gersuk, Freddy D Campos, Iza Perez-Martinez, Mario Meza-Segura, Damien Chaussabel, Jacques Banchereau, Teresa Estrada-Garcia, Peter S Linsley
Globally, diarrheal diseases are a leading cause of death in children under five and disproportionately affect children in developing countries. Children who contract diarrheal diseases are rarely screened to identify the etiologic agent due to time and cost considerations associated with pathogen-specific screening and hence pathogen-directed therapy is uncommon. The development of biomarkers to rapidly identify underlying pathogens could improve treatment options and clinical outcomes in childhood diarrheal diseases...
2018: PloS One
https://www.readbyqxmd.com/read/29376346/synthesis-of-prebiotic-caramels-catalyzed-by-ion-exchange-resin-particles-kinetic-model-for-the-formation-of-di-d-fructose-dianhydrides
#14
Imelda-Elizabeth Ortiz Cerda, Phahath Thammavong, Vincent Caqueret, Catherine Porte, Isabelle Mabille, José Manuel García Fernández, Mario Moscosa Santillan, Jean-Louis Havet
Caramel enriched in di-D-fructose dianhydrides (DFAs, a family of prebiotic cyclic fructodisaccharides) is a functional food with beneficial properties for health. The aim of this work was to study the conversion of fructose into DFAs catalyzed by acid ion-exchange resin, in order to establish a simplified mechanism of the caramelization reaction and a kinetic model for DFA formation. Batch reactor experiments were carried out in a 250 mL spherical glass flask and afforded up to 50%DFA yields. The mechanism proposed entails order 2 reactions that describe fructose conversion on DFAs or formation of by-products such as HMF or melanoidins...
January 27, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29372649/differential-expression-of-snornas-in-oral-squamous-cell-carcinomas-new-potential-diagnostic-markers
#15
Cintia Chamorro-Petronacci, Mario Perez-Sayáns, Maria Elena Padín-Iruegas, Xabier Marichalar-Mendia, Mercedes Gallas-Torreira, Abel García García
BACKGROUND: Small nucleolar RNAs (snoRNAs) are small non-coding RNA sequences whose most studied function is ribosome biogenesis. The altered expression of snoRNA is observed in tumoral processes such as breast cancer and multiple myeloma. However, we have not found any references to snoRNAs in oral squamous cell carcinomas (OSCC) in the literature at the time this article was written. MATERIAL AND METHODS: We have analyzed snoRNA expression in frozen OSCC tissue samples and have compared them to healthy controls...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29364698/prevalence-and-characterization-of-staphylococcus-aureus-strains-in-the-pork-chain-supply-in-chile
#16
Valeria Velasco, José L Vergara, Ana M Bonilla, Javier Muñoz, Alejandra Mallea, Diego Vallejos, Mario Quezada-Aguiluz, Jorge Campos, Pedro Rojas-García
The detection of methicillin-resistant Staphylococcus aureus (MRSA) and other emerging strains in meat-producing animals and retail meat has increased the risk of contamination of food. The aim of this study was to determine the prevalence and characterize S. aureus strains isolated from the pork chain supply in Chile. A total of 487 samples were collected: 332 samples from pigs at farms and slaughterhouses (nasal, n = 155; skin, n = 177); 85 samples from carcasses at slaughterhouses; and 70 meat samples at supermarkets and retail stores...
January 24, 2018: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29356211/impact-of-anti-hcv-direct-antiviral-agents-on-graft-function-and-immunosuppressive-drug-levels-in-kidney-transplant-recipients-a-call-to-attention-in-the-mid-term-follow-up
#17
Mario Fernández-Ruiz, Natalia Polanco, Ana García-Santiago, Raquel Muñoz, Ana M Hernández, Esther González, Verónica R Mercado, Inmaculada Fernández, José María Aguado, Manuel Praga, Amado Andrés
The medium-term impact on graft function and immunosuppressive drug pharmacokinetics of direct antiviral agents (DAAs) among hepatitis C virus (HCV)-infected kidney transplant (KT) recipients remains unclear. We compared pre- and post-treatment 12-month trajectories of estimated glomerular filtration rate (ΔeGFR) and 24-hour proteinuria (Δ24-hour proteinuria) in 49 recipients treated with DAAs (mostly sofosbuvir plus ledipasvir). Among evaluable patients, 66.7% and 100.0% had undetectable viral load by week 4 and end of therapy (EoT)...
January 22, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29356178/programmed-death-ligand-1-expression-as-immunotherapeutic-target-in-sinonasal-cancer
#18
Cristina Riobello, Blanca Vivanco, Sara Reda, Alejandro López-Hernández, Cristina García-Inclán, Sira Potes-Ares, Virginia N Cabal, Fernando López, José Luis Llorente, Mario A Hermsen
BACKGROUND: Sinonasal cancer carries a poor prognosis, especially in recurrent stages, and it is a disease with very limited treatment options. METHODS: The expression of programmed death ligand-1 (PD-L1) as a marker for immunotherapy was evaluated in 53 sinonasal squamous cell carcinoma (SCC) and 126 intestinal-type adenocarcinoma (ITAC) samples. Results were correlated to clinicopathological characteristics and follow-up data. RESULTS: Membranous PD-L1 staining of tumor cells was observed in 34% (18/53) of the sinonasal SCC samples and in 17% (22/126) of the ITAC samples...
January 22, 2018: Head & Neck
https://www.readbyqxmd.com/read/29352848/association-between-perceived-level-of-stress-clinical-characteristics-and-psychopathological-symptoms-in-women-with-systemic-lupus-erythematosus
#19
María Isabel Peralta-Ramírez, José Manuel Pérez-Mármol, Margarita Castañeda-Cabestany, Ana María Santos-Ruiz, Eva Montero-López, José Luís Callejas-Rubio, Nuria Navarrete-Navarrete, José Carlos Fernández-Sánchez, Juan Francisco Jiménez-Alonso, Norberto Ortego-Centeno, José Mario Sabio, Marta García-Morales
OBJECTIVES: To evaluate psychopathological status and stress level from a sample with SLE; compare mental functioning and stress levels between women with SLE and healthy women; determine whether disease duration, disease activity, cumulative organ damage and stress have an influence on psychopathological symptoms in SLE patients; and evaluate whether perception of stress is related to SLE severity. METHODS: We conducted a cross-sectional study of 425 participants; 202 women with SLE, with an average age (SD) of 36...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29349375/the-use-of-bovine-pericardial-patch-for-vascular-reconstruction%C3%A2-in-infected-fields-for-transplant-recipients
#20
Sandra Garcia Aroz, Mario Spaggiari, Hoonbae Jeon, Jose Oberholzer, Enrico Benedetti, Ivo Tzvetanov
Infectious vascular complications affecting transplant recipients may lead to severe morbidity and graft loss. This is a retrospective review of vascular repair with bovine pericardial patch (BPP) in infected fields for immunosuppressed patients. BPP was used as either a patch or an interposition graft. Five cases of arterial reconstruction in infected fields using BPP were performed. There were no complications related to bleeding, thrombosis, or recurrent infection. In our limited experience, the use of BPP as a vascular patch is successful, and it represents an alternative when vascular reconstruction is needed in the context of infected fields...
March 2017: Journal of Vascular Surgery Cases and Innovative Techniques
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