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https://www.readbyqxmd.com/read/28442440/impact-of-dose-and-surface-features-on-plasmatic-and-liver-concentrations-of-biodegradable-polymeric-nanocapsules
#1
Líliam Teixeira Oliveira, Mônica Auxiliadora de Paula, Bruno Mendes Roatt, Giani Martins Garcia, Luan Silvestro Bianchini Silva, Alexandre Barbosa Reis, Carina Silva de Paula, José Mário Carneiro Vilela, Margareth Spangler Andrade, Gwenaelle Pound-Lana, Vanessa Carla Furtado Mosqueira
The effect of polymeric nanocapsule dose on plasmatic and liver concentrations 20min after intravenous administration in mice was evaluated. Nanocapsules were prepared with different polymers, namely, poly(D,L-lactide) (PLA), polyethylene glycol-block-poly(D,L-lactide) (PLA-PEG), and PLA with chitosan (PLA-Cs) and compared with a nanoemulsion. These formulations were labelled with a phthalocyanine dye for fluorescent detection. The nanostructures had narrow size distributions upon separation by asymmetric flow field flow fractionation with static and dynamic light scattering detection, with average hydrodynamic diameters in the 130-300nm range, negative zeta potentials, except PLA-Cs nanocapsules, which had a positive zeta potential...
April 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28441001/-mexican-asthma-guidelines-guima-2017
#2
Désirée Larenas-Linnemann, Jorge Salas-Hernández, Juan Carlos Vázquez-García, Ignacio Ortiz-Aldana, Margarita Fernández-Vega, Blanca Estela Del Río-Navarro, María Del Carmen Cano-Salas, Jorge Agustín Luna-Pech, José Antonio Ortega-Martell, Jade Romero-Lombard, Erika Del Carmen López-Estrada, Jimena Villaverde-Rosas, José Luis Mayorga-Butrón, Mario Humberto Vargas-Becerra, Martín Bedolla-Barajas, Noel Rodríguez-Pérez, Ambrocio Aguilar-Aranda, Carlos Adrián Jiménez-González, Carlos García-Bolaños, Claudia Garrido-Galindo, David Alejandro Mendoza-Hernández, Enrique Mendoza-López, Gerardo López-Pérez, Guillermo Hideo Wakida-Kuzonoki, Héctor Hernán Ruiz-Gutiérrez, Héctor León-Molina, Héctor Martínez-De la Lanza, Héctor Stone-Aguilar, Javier Gómez-Vera, Jorge Olvera-Salinas, José Joel Oyoqui-Flores, José Luis Gálvez-Romero, José Santos Lozano-Sáenz, Juan Ignacio Salgado-Gama, Marcos Alejandro Jiménez-Chobillon, Martha Angélica García-Avilés, Martha Patricia Guinto-Balanzar, Miguel Alejandro Medina-Ávalos, Robert Camargo-Angeles, Rogelio García-Torrentera, Saraí Toral-Freyre, Gabriel Montes-Narváez, Héctor Solorio-Gómez, Juan Rosas-Peña, Sergio Jesús Romero-Tapia, Adela Reyes-Herrera, Francisco Cuevas-Schacht, Joaquín Esquer-Flores, José Antonio Sacre-Hazouri, Lorenzo Compean-Martínez, Pablo Julián Medina-Sánchez, Sergio Garza-Salinas, Carlos Báez-Loyola, Iraís Romero-Alvarado, José Luis Miguel-Reyes, Laura Elizabeth Huerta-Espinosa, Manuel Ángel Correa-Flores, Ricardo Castro-Martínez
BACKGROUND: The need for a national guideline, with a broad basis among specialists and primary care physicians was felt in Mexico, to try unifying asthma management. As several high-quality asthma guidelines exist worldwide, it was decided to select the best three for transculturation. METHODS: Following the internationally recommended methodology for guideline transculturation, ADAPTE, a literature search for asthma guidelines, published 1-1-2007 through 31-12-2015 was conducted...
2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/28439445/ultrasound-guided-continuous-interpectoral-block-for-patient-undergoing-mastectomy-and-axillary-clearance
#3
Mario Fajardo-Pérez, Ece Yamak Altınpulluk, Javier García-Miguel, Borja Quintana-Gordon
Using a single dose of local anaesthetics has some disadvantages and provides limited analgesia depending on the pharmacokinetic characteristics of the local anaesthetic used. Nevertheless, the use of continuous perineural infusions allows sustained pain control. Ultrasound-guided interpectoral block followed by the placement of catheters in patients undergoing mastectomies with or without lymph node axillary dissections can result in sufficient pain control. We present a case of a 58-year-old woman undergoing mastectomy and axillary clearance who received ultrasound-guided continuous interpectoral block for postoperative analgesia...
April 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/28438424/-avascular-necrosis-of-the-capitellum-humeri-a-report-of-clinical-radiological-case
#4
Blanca Arenas García, María Pilar Arenas García, Javier Sánchez Hernández, Mario Folgueral Pérez
No abstract text is available yet for this article.
April 21, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28437777/testing-decontaminated-sediments-as-a-substrate-for-ornamentals-in-field-nursery-plantations
#5
Francesca Ugolini, Costanza Calzolari, Giuseppe Mario Lanini, Luciano Massetti, Stefania Pollaki, Antonio Raschi, Francesco Sabatini, Giacomo Tagliaferri, Fabrizio Ungaro, Daniele Massa, Maurizio Antonetti, Carlos Garcia Izquierdo, Cristina Macci, Grazia Masciandaro
When canals and harbours are dredged, huge amount of polluted sediments has to be stocked and transported to the landfill with incredibly high costs of management. Among the remediation techniques for the reclamation of polluted sediments and soils, phytoremediation represents a sustainable and effective technique though still not fully promoted or commercialized. In this study we have tested the suitability for plant nursing of a substrate resulting from sediments dredged from a canal and treated with phytoremediation...
April 21, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28420878/synergistic-antimicrobial-effects-of-silver-transition-metal-combinatorial-treatments
#6
Javier A Garza-Cervantes, Arturo Chávez-Reyes, Elena C Castillo, Gerardo García-Rivas, Oscar Antonio Ortega-Rivera, Eva Salinas, Margarita Ortiz-Martínez, Sara Leticia Gómez-Flores, Jorge A Peña-Martínez, Alan Pepi-Molina, Mario T Treviño-González, Xristo Zarate, María Elena Cantú-Cárdenas, Carlos Enrique Escarcega-Gonzalez, J Rubén Morones-Ramírez
Due to the emergence of multi-drug resistant strains, development of novel antibiotics has become a critical issue. One promising approach is the use of transition metals, since they exhibit rapid and significant toxicity, at low concentrations, in prokaryotic cells. Nevertheless, one main drawback of transition metals is their toxicity in eukaryotic cells. Here, we show that the barriers to use them as therapeutic agents could be mitigated by combining them with silver. We demonstrate that synergism of combinatorial treatments (Silver/transition metals, including Zn, Co, Cd, Ni, and Cu) increases up to 8-fold their antimicrobial effect, when compared to their individual effects, against E...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28420803/comparison-of-the-american-college-of-cardiology-american-heart-association-and-the-european-society-of-cardiology-guidelines-for-the-management-of-patients-with-valvular-heart-disease
#7
Aya J Alame, Aris Karatasakis, Judit Karacsonyi, Barbara A Danek, Paul Sorajja, Mario Gössl, Santiago Garcia, Hani Jneid, Nikolaos Kakouros, Jose Roberto Martinez-Parachini, Erica Resendes, Pratik Kalsaria, Michele Roesle, Bavana V Rangan, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: The American College of Cardiology/American Heart Association (ACC/AHA) and the European Society of Cardiology (ESC) have developed guidelines to assist clinicians in making evidence-based decisions. This study compares the ACC/AHA and ESC guidelines for the management of patients with valvular heart disease (VHD). METHODS: The current ACC/AHA and ESC guidelines for VHD, last updated in 2014 and 2012, respectively, were compared by class of recommendation (COR), level of evidence (LOE), and content...
April 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28418823/dual-energy-ct-in-cardiovascular-imaging-edited-by-patricia-m-carrascosa-ricardo-c-cury-mario-garcia-and-jonathon-a-leipsic-new-york-ny-springer-science-business-media-2015-isbn-978-3-319-21226-5-hardcover-109-00-pp-277
#8
https://www.readbyqxmd.com/read/28411628/accurate-and-sensitive-determination-of-molar-fractions-of-13-c-labeled-intracellular-metabolites-in-cell-cultures-grown-in-the-presence-of-isotopically-labeled-glucose
#9
Mario Fernández-Fernández, Pablo Rodríguez-González, David Hevia Sánchez, Pedro González-Menéndez, Rosa M Sainz Menéndez, J Ignacio García Alonso
This work describes a methodology based on multiple linear regression and GC-MS for the determination of molar fractions of isotopically-labeled intracellular metabolites in cell cultures. Novel aspects of this work are: i) the calculation of theoretical isotopic distributions of the different isotopologues from an experimentally measured value of % 13C enrichment of the labeled precursor ii) the calculation of the contribution of lack of mass resolution of the mass spectrometer and different fragmentation mechanism such as the loss or gain of hydrogen atoms in the EI source to measure the purity of the selected cluster for each metabolite and iii) the validation of the methodology not only by the analysis of gravimetrically prepared mixtures of isotopologues but also by the comparison of the obtained molar fractions with experimental values obtained by GC-Combustion-IRMS based on (13)C/(12)C isotope ratio measurements...
May 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28411165/vitamin-d-and-sj%C3%A3-gren-syndrome
#10
REVIEW
Mario Garcia-Carrasco, Erick Alejandro Jiménez-Herrera, Jose Luis Gálvez-Romero, Luis Vázquez de Lara, Claudia Mendoza-Pinto, Ivet Etchegaray-Morales, Pamela Munguía-Realpozo, Alejandro Ruíz-Argüelles, Rosas Jose, Mauricio Vera-Recabarren, Ricard Cervera
The immunomodulatory effects of vitamin D have been extensively studied in the context of autoimmunity. Multiple studies have demonstrated a high prevalence of vitamin D deficiency in autoimmune diseases. Recently, a possible protective role of vitamin D in autoimmunity has been described; however, this function remains controversial. Few studies have investigated the role of vitamin D in patients with Sjögren syndrome (SS). In this review, we compiled the main features of SS pathogenesis, the vitamin D immunomodulatory effects and the possible interaction between both...
April 12, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28410151/effect-of-ancestry-on-interleukin-10-haplotypes-in-chronic-periodontitis
#11
Camile de Barros Lopes, Regina Fatima Feio Barroso, Rommel Mario Rodrigues Burbano, Patricia Aleixo Garcia, Pablo Diego do Carmo Pinto, Ney Pereira Carneiro Dos Santos, Sidney Emanuel Batista Santos, Andrea Kely Campos Ribeiro-Dos-Santos
Chronic periodontitis is caused by an inflammatory reaction of the periodontal tissues and alveolar bone. This inflammation is caused by periodontopathic bacteria located in the subgingival biofilm, resulting in inflammatory reactions that may lead to loss of attachment. This tissue destruction is a consequence of host immune and inflammatory responses to specific periodontal pathogens and their metabolic products. Cytokines modulate the immune response, altering its efficiency in the competition against pathogens and increasing periodontal susceptibility...
June 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28406244/cortistatin-reduces-atherosclerosis-in-hyperlipidemic-apoe-deficient-mice-and-the-formation-of-foam-cells
#12
Virginia Delgado-Maroto, Raquel Benitez, Irene Forte-Lago, Maria Morell, Elena Maganto-Garcia, Luciana Souza-Moreira, Francisco O'Valle, Mario Duran-Prado, Andrew H Lichtman, Elena Gonzalez-Rey, Mario Delgado
Atherosclerosis is a chronic inflammatory cardiovascular disease that is responsible of high mortality worldwide. Evidence indicates that maladaptive autoimmune responses in the arterial wall play critical roles in the process of atherosclerosis. Cortistatin is a neuropeptide expressed in the vascular system and atherosclerotic plaques that regulates vascular calcification and neointimal formation, and inhibits inflammation in different experimental models of autoimmune diseases. Its role in inflammatory cardiovascular disorders is largely unexplored...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28390980/semi-synthetic-sapogenin-exerts-neuroprotective-effects-by-skewing-the-brain-ischemia-reperfusion-transcriptome-towards-inflammatory-resolution
#13
Laura García-Pupo, Jeney Ramírez Sánchez, Dariusz Ratman, Claudina Pérez-Novo, Ken Declerck, Karolien De Bosscher, Marios Nektarios Markakis, Gerrit Beemster, Armando Zaldo, Yanier Nuñez Figueredo, René Delgado Hernández, Wim Vanden Berghe
Stroke represents one of the first causes of mortality and morbidity worldwide. We evaluated the therapeutic potential of a novel semi-synthetic spirosteroid sapogenin derivative "S15" in a transient middle cerebral artery occlusion (tMCAO) focal ischemia model in rat. S15-treated rats had significantly reduced infarct volumes and improved neurological functions at 24 h post-reperfusion, compared with ischemia. Corresponding gene expression changes in brain were characterized by mRNA sequencing and qPCR approaches...
April 5, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28390741/treatment-options-for-the-closure-of-secundum-atrial-septal-defects-a-systematic-review-and-meta-analysis
#14
Pedro A Villablanca, David A Briston, Josep Rodés-Cabau, David F Briceno, Gaurav Rao, Mohammed Aljoudi, Aman M Shah, Divyanshu Mohananey, Tanush Gupta, Mohammed Makkiya, Harish Ramakrishna, Mario J Garcia, Robert H Pass, Giles Peek, Ali N Zaidi
BACKGROUND: Secundum atrial septal defects (ASDs) are treated by surgical closure (SC) or transcatheter device closure (TCC). Due to a scarcity of data directly comparing these approaches, it remains unclear which is superior. This meta-analysis compares the clinical outcomes of the two treatment options. METHODS: A literature search was performed in MEDLINE, Embase, PubMed, Google Search, and Cochrane databases for studies directly comparing SC and TCC of ASDs...
March 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28386549/anti-inflammatory-effect-of-dialyzable-leukocyte-extract-in-autoimmune-prostatitis-evaluation-in-animal-model
#15
Carlos Pérez-Alvarado, Consuelo Gómez, Miguel Reyes, Mario García, Elizabeth Pérez, Carlos Pérez de la Mora, Virginia Sanchez, D Guillermo Pérez Ishiwara
Objective. To evaluate the anti-inflammatory properties of Dialyzable Leukocyte Extract (DLE) in a murine model of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Methods. Histopathological characterization, prostatein Enzyme-Linked Immunosorbent Assay, and immunohistochemical analysis for CD45, TNF-α, IFN-γ, IL-6, IL-17, and IL-4 molecules were done in prostatic Wistar rats treated with DLE, placebo, or Dexamethasone. Results. Histopathological analysis of animals induced to prostatitis showed inflammatory infiltrate, mainly constituted by leucocytes and mast cells as well as Benign Prostatic Hyperplasia...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28369662/early-pleistocene-hominin-deciduous-teeth-from-the-homo-antecessor-gran-dolina-td6-bearing-level-sierra-de-atapuerca-spain
#16
José María Bermúdez de Castro, María Martinón-Torres, Laura Martín-Francés, Marina Martínez de Pinillos, Mario Modesto-Mata, Cecilia García-Campos, Xiujie Wu, Song Xing, Wu Liu
OBJECTIVES: During the last 13 years, the late Early Pleistocene Gran Dolina-TD6-2 level (Sierra de Atapuerca, northern Spain) has yielded an additional sample of 26 dental specimens attributed to Homo antecessor. In this report, we present a descriptive and comparative study of the six deciduous teeth. METHODS: We provide external and internal morphological descriptions following classical terminology, as well as the mesiodistal and buccolingual measurements of the teeth...
March 31, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28363355/association-of-obesity-with-in-hospital-mortality-of-cardiogenic-shock-complicating-acute-myocardial-infarction
#17
Kshitij Chatterjee, Tanush Gupta, Abhinav Goyal, Dhaval Kolte, Sahil Khera, Anusha Shanbhag, Kavisha Patel, Pedro Villablanca, Nayan Agarwal, Wilbert S Aronow, Mark A Menegus, Gregg C Fonarow, Deepak L Bhatt, Mario J Garcia, Nikhil K Meena
Several previous studies have shown obesity to be counterintuitively associated with more favorable mortality in patients with acute myocardial infarction (AMI); however, the association of obesity with in-hospital mortality of cardiogenic shock complicating AMI has not been previously examined. We queried the 2004 to 2013 National Inpatient Sample databases to identify all patients ≥18 years hospitalized with the principal diagnosis of AMI. Multivariable regression models adjusting for demographics, hospital characteristics, and co-morbidities were used to examine differences in incidence and in-hospital mortality of cardiogenic shock complicating AMI between obese and nonobese patients...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28353624/cochlear-implants-versus-hearing-aids-in-a-middle-income-country-costs-productivity-and-quality-of-life
#18
Felipe Montes, Augusto Peñaranda, Santiago Correa, Daniel Peñaranda, Juan-Manuel García, Maria Leonor Aparicio, Andrea Ramírez Varela, Mario Castillo
OBJECTIVE: In Colombia there are three main treatment approaches for bilateral profound sensorineural hearing loss, also known as profound deafness (PD): cochlear implants (CI), hearing aids (HA), and no treatment (NT). The objective of this study is to determine the optimal treatment approach for PD in terms of productivity and cost-effectiveness. STUDY DESIGN: Hearing levels and SES data were obtained from audiometric tests conducted on 100 patients with CI. For each treatment approach, productivity and cost-effectiveness assessments were estimated using influence diagrams and Monte Carlo simulations...
March 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28348804/cytolethal-distending-toxin-producing-escherichia-coli-strains-causing-severe-diarrhoea-in-young-mexican-children
#19
Mario Meza-Segura, Mussaret Bano Zaidi, Samantha Maldonado-Puga, Jazmin Huerta-Cantillo, Lucia Chavez-Dueñas, Fernando Navarro-Garcia, Teresa Estrada-Garcia
Introduction. Cytolethal distending toxins (CDTs), encoded by cdt genes, have DNase activity leading to cellular and nuclear distension, resulting in irreversible cell cycle arrest and apoptosis of target cells. cdt-positive Escherichia coli strains have been isolated from children with diarrhoea. There is, however, scant information on the prevalence and clinical presentation of diarrhoeal disease caused by these strains. Furthermore, toxin production of cdt-positive strains is rarely confirmed. We report five young children with diarrhoea caused by CDT-producing E...
February 2017: JMM Case Reports
https://www.readbyqxmd.com/read/28343624/salivary-%C3%AE-2-microglobulin-positively-correlates-with-esspri-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#20
Felipe Garza-García, Guillermo Delgado-García, Mario Garza-Elizondo, Luis Ángel Ceceñas-Falcón, Dionicio Galarza-Delgado, Janett Riega-Torres
No abstract text is available yet for this article.
March 2017: Revista Brasileira de Reumatologia
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