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https://www.readbyqxmd.com/read/28533929/does-ischemic-burden-on-stress-testing-influence-patient-survival-in-subjects-with-known-severe-multi-vessel-cad
#1
Shey Mukundan, Mark I Travin, Jeffrey M Levsky, Matthew P Liakos, Daniel M Spevack
BACKGROUND: Ischemic burden observed during stress testing has been postulated to predict prognosis irrespective of anatomic atherosclerotic burden observed on angiography. However, it is not known if the stress test result influences the long-term prognosis of subjects with diffuse coronary artery disease. We sought to determine the prognostic importance of stress test false negativity amongst patients with severe multi-vessel coronary artery disease (CAD) undergoing stress testing in the previous decade...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28259133/aging-in-birds
#2
REVIEW
D Y Travin, B A Feniouk
Rodents are the most commonly used model organisms in studies of aging in vertebrates. However, there are species that may suit this role much better. Most birds (Aves), having higher rate of metabolism, live two-to-three times longer than mammals of the same size. This mini-review briefly covers several evolutionary, ecological, and physiological aspects that may contribute to the phenomenon of birds' longevity. The role of different molecular mechanisms known to take part in the process of aging according to various existing theories, e...
December 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28193779/combination-targeted-therapy-to-disrupt-aberrant-oncogenic-signaling-and-reverse-epigenetic-dysfunction-in-idh2-and-tet2-mutant-acute-myeloid-leukemia
#3
Alan H Shih, Cem Meydan, Kaitlyn Shank, Francine E Garrett-Bakelman, Patrick S Ward, Andrew M Intlekofer, Abbas Nazir, Eytan M Stein, Kristina Knapp, Jacob Glass, Jeremy Travins, Kim Straley, Camelia Gliser, Christopher E Mason, Katharine Yen, Craig B Thompson, Ari Melnick, Ross L Levine
Genomic studies in acute myeloid leukemias (AML) have identified mutations that drive altered DNA methylation, including TET2 and IDH2 Here, we show that models of AML resulting from TET2 or IDH2 mutations combined with FLT3(ITD) mutations are sensitive to 5-azacytidine or to the IDH2 inhibitor AG-221, respectively. 5-azacytidine and AG-221 treatment induced an attenuation of aberrant DNA methylation and transcriptional output and resulted in a reduction in leukemic blasts consistent with antileukemic activity...
May 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28193778/ag-221-a-first-in-class-therapy-targeting-acute-myeloid-leukemia-harboring-oncogenic-idh2-mutations
#4
Katharine Yen, Jeremy Travins, Fang Wang, Muriel D David, Erin Artin, Kimberly Straley, Anil Padyana, Stefan Gross, Byron DeLaBarre, Erica Tobin, Yue Chen, Raj Nagaraja, Sung Choe, Lei Jin, Zenon Konteatis, Giovanni Cianchetta, Jeffrey O Saunders, Francesco G Salituro, Cyril Quivoron, Paule Opolon, Olivia Bawa, Véronique Saada, Angelo Paci, Sophie Broutin, Olivier A Bernard, Stéphane de Botton, Benoît S Marteyn, Monika Pilichowska, YingXia Xu, Cheng Fang, Fan Jiang, Wentao Wei, Shengfang Jin, Lee Silverman, Wei Liu, Hua Yang, Lenny Dang, Marion Dorsch, Virginie Penard-Lacronique, Scott A Biller, Shin-San Michael Su
Somatic gain-of-function mutations in isocitrate dehydrogenases (IDH) 1 and 2 are found in multiple hematologic and solid tumors, leading to accumulation of the oncometabolite (R)-2-hydroxyglutarate (2HG). 2HG competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone demethylases and methylcytosine dioxygenases of the TET family, causing epigenetic dysregulation and a block in cellular differentiation. In vitro studies have provided proof of concept for mutant IDH inhibition as a therapeutic approach...
February 13, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/27861299/impact-of-concomitant-medication-use-on-myocardial-123i-mibg-imaging-results-in-patients-with-heart-failure
#5
Arnold F Jacobson, Susan White, Mark I Travin, Carol Tseng
INTRODUCTION: Medications that interfere with sympathetic neuronal norepinephrine uptake and storage, such as neuropsychiatrics (NP) and sympathomimetic amines, are most likely to affect cardiac uptake of iodine-123 metaiodobenzylguanidine (I-mIBG). The present study examined these and other medications reported to affect I-mIBG uptake using measurements of cardiac I-mIBG uptake on the heart failure (HF) patients in the ADMIRE-HF extension (X) study. METHODS: Baseline concomitant medications taken by the 961 HF patients were categorized into five groups: calcium channel blockers, NP medications, β agonists and sympathomimetics, α antagonists, and other antihypertensives...
February 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27650444/potential-for-adrenergic-imaging-to-serve-as-a-unique-tool-for-guidance-of-patient-management-during-and-after-an-acute-ischemic-event
#6
Mark I Travin
No abstract text is available yet for this article.
September 20, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27590662/a-full-body-transcriptome-and-proteome-resource-for-the-european-common-carp
#7
I C R M Kolder, S J van der Plas-Duivesteijn, G Tan, G F Wiegertjes, M Forlenza, A T Guler, D Y Travin, M Nakao, T Moritomo, I Irnazarow, J T den Dunnen, S Y Anvar, H J Jansen, R P Dirks, M Palmblad, B Lenhard, C V Henkel, H P Spaink
BACKGROUND: The common carp (Cyprinus carpio) is the oldest, most domesticated and one of the most cultured fish species for food consumption. Besides its economic importance, the common carp is also highly suitable for comparative physiological and disease studies in combination with the animal model zebrafish (Danio rerio). They are genetically closely related but offer complementary benefits for fundamental research, with the large body mass of common carp presenting possibilities for obtaining sufficient cell material for advanced transcriptome and proteome studies...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27469509/a-small-molecule-inhibitor-of-mutant-idh2-rescues-cardiomyopathy-in-a-d-2-hydroxyglutaric-aciduria-type-ii-mouse-model
#8
Fang Wang, Jeremy Travins, Zhizhong Lin, Yaguang Si, Yue Chen, Josh Powe, Stuart Murray, Dongwei Zhu, Erin Artin, Stefan Gross, Stephanie Santiago, Mya Steadman, Andrew Kernytsky, Kimberly Straley, Chenming Lu, Ana Pop, Eduard A Struys, Erwin E W Jansen, Gajja S Salomons, Muriel D David, Cyril Quivoron, Virginie Penard-Lacronique, Karen S Regan, Wei Liu, Lenny Dang, Hua Yang, Lee Silverman, Samuel Agresta, Marion Dorsch, Scott Biller, Katharine Yen, Yong Cang, Shin-San Michael Su, Shengfang Jin
D-2-hydroxyglutaric aciduria (D2HGA) type II is a rare neurometabolic disorder caused by germline gain-of-function mutations in isocitrate dehydrogenase 2 (IDH2), resulting in accumulation of D-2-hydroxyglutarate (D2HG). Patients exhibit a wide spectrum of symptoms including cardiomyopathy, epilepsy, developmental delay and limited life span. Currently, there are no effective therapeutic interventions. We generated a D2HGA type II mouse model by introducing the Idh2R140Q mutation at the native chromosomal locus...
November 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27417443/multimodality-molecular-imaging-in-predicting-ventricular-arrhythmias-and-sudden-cardiac-death
#9
Mark I Travin
No abstract text is available yet for this article.
February 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27392702/asnc-imaging-guidelines-snmmi-procedure-standard-for-positron-emission-tomography-pet-nuclear-cardiology-procedures
#10
Vasken Dilsizian, Stephen L Bacharach, Rob S Beanlands, Steven R Bergmann, Dominique Delbeke, Sharmila Dorbala, Robert J Gropler, Juhani Knuuti, Heinrich R Schelbert, Mark I Travin
No abstract text is available yet for this article.
October 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27068473/mtap-deletions-in-cancer-create-vulnerability-to-targeting-of-the-mat2a-prmt5-riok1-axis
#11
Katya Marjon, Michael J Cameron, Phong Quang, Michelle F Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L Blake, Jeremy Travins, Marion Dorsch, Scott A Biller, Kevin M Marks
Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (MTAP). Here, we used shRNA screening and identified the metabolic enzyme, methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5, as vulnerable enzymes in cells with MTAP deletion. Metabolomic and biochemical studies revealed a mechanistic basis for this synthetic lethality. The MTAP substrate methylthioadenosine (MTA) accumulates upon MTAP loss...
April 19, 2016: Cell Reports
https://www.readbyqxmd.com/read/26961077/erratum-to-asnc-imaging-guidelines-for-spect-nuclear-cardiology-procedures-stress-protocols-and-tracers
#12
Milena J Henzlova, W Lane Duvall, Andrew J Einstein, Mark I Travin, Hein J Verberne
No abstract text is available yet for this article.
March 9, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/26914678/asnc-imaging-guidelines-for-spect-nuclear-cardiology-procedures-stress-protocols-and-tracers
#13
Milena J Henzlova, W Lane Duvall, Andrew J Einstein, Mark I Travin, Hein J Verberne
No abstract text is available yet for this article.
June 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/26856060/-amniotic-fluid-embolism-as-a-cause-of-maternal-death
#14
A P Nadeev, V A Zhukova, T A Ageeva, A N Drobinskaya, M A Travin, M A Karpov, S V Savchenko, Yu V Chikinev, A S Polyakevich
This article reports the case of death of a puerperal woman resulting from amniotic fluid embolism. The diagnosis was established based on the results of the pathohistological study that revealed the presence of mucoproteides and epithelial scales in pulmonary blood vessels and capillaries.
November 2015: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/26791866/assessment-of-123-i-mibg-and-99m-tc-tetrofosmin-single-photon-emission-computed-tomographic-images-for-the-prediction-of-arrhythmic-events-in-patients-with-ischemic-heart-failure-intermediate-severity-innervation-defects-are-associated-with-higher-arrhythmic
#15
Mark I Travin, Milena J Henzlova, Berthe L F van Eck-Smit, Diwakar Jain, Ignasi Carrió, Russell D Folks, Ernest V Garcia, Arnold F Jacobson, Hein J Verberne
RATIONALE: (123)I-mIBG planar image heart-to-mediastinum ratios effectively risk-stratify heart failure (HF) patients. The value of single-photon emission computed tomographic (SPECT) imaging for identifying increased risk of ventricular arrhythmias is less clear. This study sought to determine if findings from simultaneous interpretation of (123)I-mIBG and (99m)Tc-tetrofosmin SPECT are predictive of arrhythmic events (ArEs). METHODS: (123)I-mIBG SPECT images from 622 patients with ischemic HF were presented in standard displays alongside (99m)Tc-tetrofosmin images...
January 20, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/26784483/coronary-computed-tomography-angiography-versus-radionuclide-myocardial-perfusion-imaging
#16
LETTER
Jeffrey M Levsky, Mark I Travin, Linda B Haramati
No abstract text is available yet for this article.
January 19, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/26590785/clinical-applications-of-myocardial-innervation-imaging
#17
REVIEW
Mark I Travin
Cardiac autonomic innervation plays an important role in regulating function. Adrenergic innervation imaging is possible with the norepinephrine analogue radiotracer iodine 123 meta-iodobenzylguanidine ((123)I-mIBG) and positron emitting tracers such carbon-11 hydroxyephedrine. (123)I-mIBG uptake is assessed globally via the heart to mediastinum ratio on planar images and regionally with tomographic imaging and has utility in various cardiac diseases. There is promise for guiding expensive invasive therapies such as implantable defibrillators, ventricular assist devices, and transplant...
February 2016: Cardiology Clinics
https://www.readbyqxmd.com/read/26278852/pitfalls-and-limitations-of-radionuclide-and-hybrid-cardiac-imaging
#18
REVIEW
Mark I Travin
Radionuclide myocardial perfusion imaging (MPI) is an important technique for evaluating the presence and severity of ischemic coronary heart disease that is widespread in the United States and much of the world. This widely used test has excellent diagnostic accuracy and strong risk-stratification utility and plays an important role in guiding patient management. As with all testing modalities, the clinical utility of MPI relies on proper procedure performance as improper techniques can lead to incorrect test interpretation, and thus misdiagnosis with potential adverse effects on patient management and outcome...
September 2015: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/26163203/asnc-snmmi-model-coverage-policy-myocardial-sympathetic-innervation-imaging-iodine-123-meta-iodobenzylguanidine-123-i-mibg
#19
M G Sciammarella, M Gerson, A E Buxton, S C Bartley, R Doukky, D A Merlino, S Tandon, R Thompson, M I Travin
No abstract text is available yet for this article.
August 2015: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/26122883/cardiac-18-f-fdg-uptake-in-chagas-disease
#20
Gunjan Garg, Stuart Cohen, Richard Neches, Mark I Travin
No abstract text is available yet for this article.
April 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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