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https://www.readbyqxmd.com/read/29083911/comics-cartoon-visualization-of-omics-data-in-spatial-context-using-anatomical-ontologies
#1
Dmitrii Travin, Iaroslav Popov, Arzu Tugce Guler, Dmitry Medvedev, Suzanne van der Plas-Duivesteijn, Monica Varela, Iris C R M Kolder, Annemarie H Meijer, Herman P Spaink, Magnus Palmblad
COMICS is an interactive and open-access Web platform for integration and visualization of molecular expression data in anatomograms of zebrafish, carp and mouse model systems. Anatomical ontologies are used to map omics data across experiments and between an experiment and a particular visualization in a data dependent manner. COMICS is built on top of several existing resources. Zebrafish and mouse anatomical ontologies with their controlled vocabulary (CV) and defined hierarchy are used with the ontoCAT R package to aggregate data for comparison and visualization...
October 30, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28846667/klebsazolicin-inhibits-70s-ribosome-by-obstructing-the-peptide-exit-tunnel
#2
Mikhail Metelev, Ilya A Osterman, Dmitry Ghilarov, Nelli F Khabibullina, Alexander Yakimov, Konstantin Shabalin, Irina Utkina, Dmitry Y Travin, Ekaterina S Komarova, Marina Serebryakova, Tatyana Artamonova, Mikhail Khodorkovskii, Andrey L Konevega, Petr V Sergiev, Konstantin Severinov, Yury S Polikanov
Whereas screening of the small-molecule metabolites produced by most cultivatable microorganisms often results in the rediscovery of known compounds, genome-mining programs allow researchers to harness much greater chemical diversity, and result in the discovery of new molecular scaffolds. Here we report the genome-guided identification of a new antibiotic, klebsazolicin (KLB), from Klebsiella pneumoniae that inhibits the growth of sensitive cells by targeting ribosomes. A ribosomally synthesized post-translationally modified peptide (RiPP), KLB is characterized by the presence of a unique N-terminal amidine ring that is essential for its activity...
October 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28681337/assessing-arrhythmic-risk-with-123-i-mibg-and-analogous-tracers-image-interpretation-from-a-different-viewpoint
#3
EDITORIAL
Mark I Travin
No abstract text is available yet for this article.
July 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28593534/neurocardiac-imaging-has-a-proven-value-in-patient-management
#4
Mark I Travin
No abstract text is available yet for this article.
October 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28533929/does-ischemic-burden-on-stress-testing-influence-patient-survival-in-subjects-with-known-severe-multi-vessel-cad
#5
Shey Mukundan, Mark I Travin, Jeffrey M Levsky, Matthew P Liakos, Daniel M Spevack
BACKGROUND: Ischemic burden observed during stress testing has been postulated to predict prognosis irrespective of anatomic atherosclerotic burden observed on angiography. However, it is not known if the stress test result influences the long-term prognosis of subjects with diffuse coronary artery disease. We sought to determine the prognostic importance of stress test false negativity amongst patients with severe multi-vessel coronary artery disease (CAD) undergoing stress testing in the previous decade...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28259133/aging-in-birds
#6
REVIEW
D Y Travin, B A Feniouk
Rodents are the most commonly used model organisms in studies of aging in vertebrates. However, there are species that may suit this role much better. Most birds (Aves), having higher rate of metabolism, live two-to-three times longer than mammals of the same size. This mini-review briefly covers several evolutionary, ecological, and physiological aspects that may contribute to the phenomenon of birds' longevity. The role of different molecular mechanisms known to take part in the process of aging according to various existing theories, e...
December 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28193779/combination-targeted-therapy-to-disrupt-aberrant-oncogenic-signaling-and-reverse-epigenetic-dysfunction-in-idh2-and-tet2-mutant-acute-myeloid-leukemia
#7
Alan H Shih, Cem Meydan, Kaitlyn Shank, Francine E Garrett-Bakelman, Patrick S Ward, Andrew M Intlekofer, Abbas Nazir, Eytan M Stein, Kristina Knapp, Jacob Glass, Jeremy Travins, Kim Straley, Camelia Gliser, Christopher E Mason, Katharine Yen, Craig B Thompson, Ari Melnick, Ross L Levine
Genomic studies in acute myeloid leukemias (AML) have identified mutations that drive altered DNA methylation, including TET2 and IDH2 Here, we show that models of AML resulting from TET2 or IDH2 mutations combined with FLT3(ITD) mutations are sensitive to 5-azacytidine or to the IDH2 inhibitor AG-221, respectively. 5-azacytidine and AG-221 treatment induced an attenuation of aberrant DNA methylation and transcriptional output and resulted in a reduction in leukemic blasts consistent with antileukemic activity...
May 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28193778/ag-221-a-first-in-class-therapy-targeting-acute-myeloid-leukemia-harboring-oncogenic-idh2-mutations
#8
Katharine Yen, Jeremy Travins, Fang Wang, Muriel D David, Erin Artin, Kimberly Straley, Anil Padyana, Stefan Gross, Byron DeLaBarre, Erica Tobin, Yue Chen, Raj Nagaraja, Sung Choe, Lei Jin, Zenon Konteatis, Giovanni Cianchetta, Jeffrey O Saunders, Francesco G Salituro, Cyril Quivoron, Paule Opolon, Olivia Bawa, Véronique Saada, Angelo Paci, Sophie Broutin, Olivier A Bernard, Stéphane de Botton, Benoît S Marteyn, Monika Pilichowska, YingXia Xu, Cheng Fang, Fan Jiang, Wentao Wei, Shengfang Jin, Lee Silverman, Wei Liu, Hua Yang, Lenny Dang, Marion Dorsch, Virginie Penard-Lacronique, Scott A Biller, Shin-San Michael Su
Somatic gain-of-function mutations in isocitrate dehydrogenases (IDH) 1 and 2 are found in multiple hematologic and solid tumors, leading to accumulation of the oncometabolite (R)-2-hydroxyglutarate (2HG). 2HG competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone demethylases and methylcytosine dioxygenases of the TET family, causing epigenetic dysregulation and a block in cellular differentiation. In vitro studies have provided proof of concept for mutant IDH inhibition as a therapeutic approach...
May 2017: Cancer Discovery
https://www.readbyqxmd.com/read/27861299/impact-of-concomitant-medication-use-on-myocardial-123i-mibg-imaging-results-in-patients-with-heart-failure
#9
Arnold F Jacobson, Susan White, Mark I Travin, Carol Tseng
INTRODUCTION: Medications that interfere with sympathetic neuronal norepinephrine uptake and storage, such as neuropsychiatrics (NP) and sympathomimetic amines, are most likely to affect cardiac uptake of iodine-123 metaiodobenzylguanidine (I-mIBG). The present study examined these and other medications reported to affect I-mIBG uptake using measurements of cardiac I-mIBG uptake on the heart failure (HF) patients in the ADMIRE-HF extension (X) study. METHODS: Baseline concomitant medications taken by the 961 HF patients were categorized into five groups: calcium channel blockers, NP medications, β agonists and sympathomimetics, α antagonists, and other antihypertensives...
February 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27650444/potential-for-adrenergic-imaging-to-serve-as-a-unique-tool-for-guidance-of-patient-management-during-and-after-an-acute-ischemic-event
#10
Mark I Travin
No abstract text is available yet for this article.
September 20, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27590662/a-full-body-transcriptome-and-proteome-resource-for-the-european-common-carp
#11
I C R M Kolder, S J van der Plas-Duivesteijn, G Tan, G F Wiegertjes, M Forlenza, A T Guler, D Y Travin, M Nakao, T Moritomo, I Irnazarow, J T den Dunnen, S Y Anvar, H J Jansen, R P Dirks, M Palmblad, B Lenhard, C V Henkel, H P Spaink
BACKGROUND: The common carp (Cyprinus carpio) is the oldest, most domesticated and one of the most cultured fish species for food consumption. Besides its economic importance, the common carp is also highly suitable for comparative physiological and disease studies in combination with the animal model zebrafish (Danio rerio). They are genetically closely related but offer complementary benefits for fundamental research, with the large body mass of common carp presenting possibilities for obtaining sufficient cell material for advanced transcriptome and proteome studies...
September 2, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27469509/a-small-molecule-inhibitor-of-mutant-idh2-rescues-cardiomyopathy-in-a-d-2-hydroxyglutaric-aciduria-type-ii-mouse-model
#12
Fang Wang, Jeremy Travins, Zhizhong Lin, Yaguang Si, Yue Chen, Josh Powe, Stuart Murray, Dongwei Zhu, Erin Artin, Stefan Gross, Stephanie Santiago, Mya Steadman, Andrew Kernytsky, Kimberly Straley, Chenming Lu, Ana Pop, Eduard A Struys, Erwin E W Jansen, Gajja S Salomons, Muriel D David, Cyril Quivoron, Virginie Penard-Lacronique, Karen S Regan, Wei Liu, Lenny Dang, Hua Yang, Lee Silverman, Samuel Agresta, Marion Dorsch, Scott Biller, Katharine Yen, Yong Cang, Shin-San Michael Su, Shengfang Jin
D-2-hydroxyglutaric aciduria (D2HGA) type II is a rare neurometabolic disorder caused by germline gain-of-function mutations in isocitrate dehydrogenase 2 (IDH2), resulting in accumulation of D-2-hydroxyglutarate (D2HG). Patients exhibit a wide spectrum of symptoms including cardiomyopathy, epilepsy, developmental delay and limited life span. Currently, there are no effective therapeutic interventions. We generated a D2HGA type II mouse model by introducing the Idh2R140Q mutation at the native chromosomal locus...
November 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27417443/multimodality-molecular-imaging-in-predicting-ventricular-arrhythmias-and-sudden-cardiac-death
#13
Mark I Travin
No abstract text is available yet for this article.
February 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27392702/asnc-imaging-guidelines-snmmi-procedure-standard-for-positron-emission-tomography-pet-nuclear-cardiology-procedures
#14
Vasken Dilsizian, Stephen L Bacharach, Rob S Beanlands, Steven R Bergmann, Dominique Delbeke, Sharmila Dorbala, Robert J Gropler, Juhani Knuuti, Heinrich R Schelbert, Mark I Travin
No abstract text is available yet for this article.
October 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27068473/mtap-deletions-in-cancer-create-vulnerability-to-targeting-of-the-mat2a-prmt5-riok1-axis
#15
Katya Marjon, Michael J Cameron, Phong Quang, Michelle F Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L Blake, Jeremy Travins, Marion Dorsch, Scott A Biller, Kevin M Marks
Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (MTAP). Here, we used shRNA screening and identified the metabolic enzyme, methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5, as vulnerable enzymes in cells with MTAP deletion. Metabolomic and biochemical studies revealed a mechanistic basis for this synthetic lethality. The MTAP substrate methylthioadenosine (MTA) accumulates upon MTAP loss...
April 19, 2016: Cell Reports
https://www.readbyqxmd.com/read/26961077/erratum-to-asnc-imaging-guidelines-for-spect-nuclear-cardiology-procedures-stress-protocols-and-tracers
#16
Milena J Henzlova, W Lane Duvall, Andrew J Einstein, Mark I Travin, Hein J Verberne
No abstract text is available yet for this article.
June 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/26914678/asnc-imaging-guidelines-for-spect-nuclear-cardiology-procedures-stress-protocols-and-tracers
#17
Milena J Henzlova, W Lane Duvall, Andrew J Einstein, Mark I Travin, Hein J Verberne
No abstract text is available yet for this article.
June 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/26856060/-amniotic-fluid-embolism-as-a-cause-of-maternal-death
#18
A P Nadeev, V A Zhukova, T A Ageeva, A N Drobinskaya, M A Travin, M A Karpov, S V Savchenko, Yu V Chikinev, A S Polyakevich
This article reports the case of death of a puerperal woman resulting from amniotic fluid embolism. The diagnosis was established based on the results of the pathohistological study that revealed the presence of mucoproteides and epithelial scales in pulmonary blood vessels and capillaries.
November 2015: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/26791866/assessment-of-123-i-mibg-and-99m-tc-tetrofosmin-single-photon-emission-computed-tomographic-images-for-the-prediction-of-arrhythmic-events-in-patients-with-ischemic-heart-failure-intermediate-severity-innervation-defects-are-associated-with-higher-arrhythmic
#19
Mark I Travin, Milena J Henzlova, Berthe L F van Eck-Smit, Diwakar Jain, Ignasi Carrió, Russell D Folks, Ernest V Garcia, Arnold F Jacobson, Hein J Verberne
RATIONALE: (123)I-mIBG planar image heart-to-mediastinum ratios effectively risk-stratify heart failure (HF) patients. The value of single-photon emission computed tomographic (SPECT) imaging for identifying increased risk of ventricular arrhythmias is less clear. This study sought to determine if findings from simultaneous interpretation of (123)I-mIBG and (99m)Tc-tetrofosmin SPECT are predictive of arrhythmic events (ArEs). METHODS: (123)I-mIBG SPECT images from 622 patients with ischemic HF were presented in standard displays alongside (99m)Tc-tetrofosmin images...
April 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/26784483/coronary-computed-tomography-angiography-versus-radionuclide-myocardial-perfusion-imaging
#20
LETTER
Jeffrey M Levsky, Mark I Travin, Linda B Haramati
No abstract text is available yet for this article.
January 19, 2016: Annals of Internal Medicine
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