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https://www.readbyqxmd.com/read/27861299/impact-of-concomitant-medication-use-on-myocardial-123i-mibg-imaging-results-in-patients-with-heart-failure
#1
Arnold F Jacobson, Susan White, Mark I Travin, Carol Tseng
INTRODUCTION: Medications that interfere with sympathetic neuronal norepinephrine uptake and storage, such as neuropsychiatrics (NP) and sympathomimetic amines, are most likely to affect cardiac uptake of iodine-123 metaiodobenzylguanidine (I-mIBG). The present study examined these and other medications reported to affect I-mIBG uptake using measurements of cardiac I-mIBG uptake on the heart failure (HF) patients in the ADMIRE-HF extension (X) study. METHODS: Baseline concomitant medications taken by the 961 HF patients were categorized into five groups: calcium channel blockers, NP medications, β agonists and sympathomimetics, α antagonists, and other antihypertensives...
November 16, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27650444/potential-for-adrenergic-imaging-to-serve-as-a-unique-tool-for-guidance-of-patient-management-during-and-after-an-acute-ischemic-event
#2
Mark I Travin
No abstract text is available yet for this article.
September 20, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27590662/a-full-body-transcriptome-and-proteome-resource-for-the-european-common-carp
#3
I C R M Kolder, S J van der Plas-Duivesteijn, G Tan, G F Wiegertjes, M Forlenza, A T Guler, D Y Travin, M Nakao, T Moritomo, I Irnazarow, J T den Dunnen, S Y Anvar, H J Jansen, R P Dirks, M Palmblad, B Lenhard, C V Henkel, H P Spaink
BACKGROUND: The common carp (Cyprinus carpio) is the oldest, most domesticated and one of the most cultured fish species for food consumption. Besides its economic importance, the common carp is also highly suitable for comparative physiological and disease studies in combination with the animal model zebrafish (Danio rerio). They are genetically closely related but offer complementary benefits for fundamental research, with the large body mass of common carp presenting possibilities for obtaining sufficient cell material for advanced transcriptome and proteome studies...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27469509/a-small-molecule-inhibitor-of-mutant-idh2-rescues-cardiomyopathy-in-a-d-2-hydroxyglutaric-aciduria-type-ii-mouse-model
#4
Fang Wang, Jeremy Travins, Zhizhong Lin, Yaguang Si, Yue Chen, Josh Powe, Stuart Murray, Dongwei Zhu, Erin Artin, Stefan Gross, Stephanie Santiago, Mya Steadman, Andrew Kernytsky, Kimberly Straley, Chenming Lu, Ana Pop, Eduard A Struys, Erwin E W Jansen, Gajja S Salomons, Muriel D David, Cyril Quivoron, Virginie Penard-Lacronique, Karen S Regan, Wei Liu, Lenny Dang, Hua Yang, Lee Silverman, Samuel Agresta, Marion Dorsch, Scott Biller, Katharine Yen, Yong Cang, Shin-San Michael Su, Shengfang Jin
D-2-hydroxyglutaric aciduria (D2HGA) type II is a rare neurometabolic disorder caused by germline gain-of-function mutations in isocitrate dehydrogenase 2 (IDH2), resulting in accumulation of D-2-hydroxyglutarate (D2HG). Patients exhibit a wide spectrum of symptoms including cardiomyopathy, epilepsy, developmental delay and limited life span. Currently, there are no effective therapeutic interventions. We generated a D2HGA type II mouse model by introducing the Idh2R140Q mutation at the native chromosomal locus...
November 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27417443/multimodality-molecular-imaging-in-predicting-ventricular-arrhythmias-and-sudden-cardiac-death
#5
Mark I Travin
No abstract text is available yet for this article.
July 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27392702/asnc-imaging-guidelines-snmmi-procedure-standard-for-positron-emission-tomography-pet-nuclear-cardiology-procedures
#6
Vasken Dilsizian, Stephen L Bacharach, Rob S Beanlands, Steven R Bergmann, Dominique Delbeke, Sharmila Dorbala, Robert J Gropler, Juhani Knuuti, Heinrich R Schelbert, Mark I Travin
No abstract text is available yet for this article.
October 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27068473/mtap-deletions-in-cancer-create-vulnerability-to-targeting-of-the-mat2a-prmt5-riok1-axis
#7
Katya Marjon, Michael J Cameron, Phong Quang, Michelle F Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L Blake, Jeremy Travins, Marion Dorsch, Scott A Biller, Kevin M Marks
Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (MTAP). Here, we used shRNA screening and identified the metabolic enzyme, methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5, as vulnerable enzymes in cells with MTAP deletion. Metabolomic and biochemical studies revealed a mechanistic basis for this synthetic lethality. The MTAP substrate methylthioadenosine (MTA) accumulates upon MTAP loss...
April 19, 2016: Cell Reports
https://www.readbyqxmd.com/read/26961077/erratum-to-asnc-imaging-guidelines-for-spect-nuclear-cardiology-procedures-stress-protocols-and-tracers
#8
Milena J Henzlova, W Lane Duvall, Andrew J Einstein, Mark I Travin, Hein J Verberne
No abstract text is available yet for this article.
March 9, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/26914678/asnc-imaging-guidelines-for-spect-nuclear-cardiology-procedures-stress-protocols-and-tracers
#9
Milena J Henzlova, W Lane Duvall, Andrew J Einstein, Mark I Travin, Hein J Verberne
No abstract text is available yet for this article.
June 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/26856060/-amniotic-fluid-embolism-as-a-cause-of-maternal-death
#10
A P Nadeev, V A Zhukova, T A Ageeva, A N Drobinskaya, M A Travin, M A Karpov, S V Savchenko, Yu V Chikinev, A S Polyakevich
This article reports the case of death of a puerperal woman resulting from amniotic fluid embolism. The diagnosis was established based on the results of the pathohistological study that revealed the presence of mucoproteides and epithelial scales in pulmonary blood vessels and capillaries.
November 2015: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/26791866/assessment-of-123-i-mibg-and-99m-tc-tetrofosmin-single-photon-emission-computed-tomographic-images-for-the-prediction-of-arrhythmic-events-in-patients-with-ischemic-heart-failure-intermediate-severity-innervation-defects-are-associated-with-higher-arrhythmic
#11
Mark I Travin, Milena J Henzlova, Berthe L F van Eck-Smit, Diwakar Jain, Ignasi Carrió, Russell D Folks, Ernest V Garcia, Arnold F Jacobson, Hein J Verberne
RATIONALE: (123)I-mIBG planar image heart-to-mediastinum ratios effectively risk-stratify heart failure (HF) patients. The value of single-photon emission computed tomographic (SPECT) imaging for identifying increased risk of ventricular arrhythmias is less clear. This study sought to determine if findings from simultaneous interpretation of (123)I-mIBG and (99m)Tc-tetrofosmin SPECT are predictive of arrhythmic events (ArEs). METHODS: (123)I-mIBG SPECT images from 622 patients with ischemic HF were presented in standard displays alongside (99m)Tc-tetrofosmin images...
January 20, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/26784483/coronary-computed-tomography-angiography-versus-radionuclide-myocardial-perfusion-imaging
#12
LETTER
Jeffrey M Levsky, Mark I Travin, Linda B Haramati
No abstract text is available yet for this article.
January 19, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/26590785/clinical-applications-of-myocardial-innervation-imaging
#13
REVIEW
Mark I Travin
Cardiac autonomic innervation plays an important role in regulating function. Adrenergic innervation imaging is possible with the norepinephrine analogue radiotracer iodine 123 meta-iodobenzylguanidine ((123)I-mIBG) and positron emitting tracers such carbon-11 hydroxyephedrine. (123)I-mIBG uptake is assessed globally via the heart to mediastinum ratio on planar images and regionally with tomographic imaging and has utility in various cardiac diseases. There is promise for guiding expensive invasive therapies such as implantable defibrillators, ventricular assist devices, and transplant...
February 2016: Cardiology Clinics
https://www.readbyqxmd.com/read/26278852/pitfalls-and-limitations-of-radionuclide-and-hybrid-cardiac-imaging
#14
REVIEW
Mark I Travin
Radionuclide myocardial perfusion imaging (MPI) is an important technique for evaluating the presence and severity of ischemic coronary heart disease that is widespread in the United States and much of the world. This widely used test has excellent diagnostic accuracy and strong risk-stratification utility and plays an important role in guiding patient management. As with all testing modalities, the clinical utility of MPI relies on proper procedure performance as improper techniques can lead to incorrect test interpretation, and thus misdiagnosis with potential adverse effects on patient management and outcome...
September 2015: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/26163203/asnc-snmmi-model-coverage-policy-myocardial-sympathetic-innervation-imaging-iodine-123-meta-iodobenzylguanidine-123-i-mibg
#15
M G Sciammarella, M Gerson, A E Buxton, S C Bartley, R Doukky, D A Merlino, S Tandon, R Thompson, M I Travin
No abstract text is available yet for this article.
August 2015: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/26122883/cardiac-18-f-fdg-uptake-in-chagas-disease
#16
Gunjan Garg, Stuart Cohen, Richard Neches, Mark I Travin
No abstract text is available yet for this article.
April 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/26052677/coronary-computed-tomography-angiography-versus-radionuclide-myocardial-perfusion-imaging-in-patients-with-chest-pain-admitted-to-telemetry-a-randomized-trial
#17
RANDOMIZED CONTROLLED TRIAL
Jeffrey M Levsky, Daniel M Spevack, Mark I Travin, Mark A Menegus, Paul W Huang, Elana T Clark, Choo-Won Kim, Esther Hirschhorn, Katherine D Freeman, Jonathan N Tobin, Linda B Haramati
BACKGROUND: The role of coronary computed tomography angiography (CCTA) in the management of symptomatic patients suspected of having coronary artery disease is expanding. However, prospective intermediate-term outcomes are lacking. OBJECTIVE: To compare CCTA with conventional noninvasive testing. DESIGN: Randomized, controlled comparative effectiveness trial. (ClinicalTrials.gov: NCT00705458). SETTING: Telemetry-monitored wards of an inner-city medical center...
August 4, 2015: Annals of Internal Medicine
https://www.readbyqxmd.com/read/25975946/impact-of-medications-on-mibg-uptake-with-specific-attention-to-the-heart-comprehensive-review-of-the-literature
#18
Arnold F Jacobson, Mark I Travin
BACKGROUND: A critical review of the literature on drug interactions with mIBG uptake was performed to allow formulation of contemporary guidance regarding withholding medications prior to clinical imaging studies. METHODS: Published information was extracted on the experimental system used, the quantitative characteristics of the measurements, and whether any data directly examining cardiac tissues were included. Level of evidence for each medication category was assessed on a qualitative scale of very low, low, medium, or high...
October 2015: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/25863305/non-invasive-assessment-of-low-risk-acute-chest-pain-in-the-emergency-department-a-comparative-meta-analysis-of-prospective-studies
#19
COMPARATIVE STUDY
Jorge Romero, S Arman Husain, Anthony A Holmes, Iosif Kelesidis, Patricia Chavez, M Khalid Mojadidi, Jeffrey M Levsky, Omar Wever-Pinzon, Cynthia Taub, Harikrishna Makani, Mark I Travin, Ileana L Piña, Mario J Garcia
BACKGROUND: The aim of this meta-analysis was to compare the diagnostic accuracy of cardiac computed tomographic angiography (CCTA), stress echocardiography (SE) and radionuclide single photon emission computed tomography (SPECT) for the assessment of chest pain in emergency department (ED) setting. METHODS: A systematic review of Medline, Cochrane and Embase was undertaken for prospective clinical studies assessing the diagnostic efficacy of CCTA, SE or SPECT, as compared to intracoronary angiography (ICA) or the later presence of major adverse clinical outcomes (MACE), in patients presenting to the ED with chest pain...
2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/25824015/i-123-mibg-cardiac-imaging
#20
Prem Soman, Mark I Travin, Myron Gerson, S James Cullom, Randall Thompson
No abstract text is available yet for this article.
August 2015: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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