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Nicolas Mansencal, Olivier Auzel, Olivier Dubourg
No abstract text is available yet for this article.
October 15, 2016: International Journal of Cardiology
Florence Paques, Etienne Hamoir, Pierre Lovinfosse, Roland Hustinx, Nadia Withofs
We present the case of a 48-year-old patient with a left adrenal incidentaloma found on computed tomography (CT) for which the diagnosis of pheochromocytoma was confirmed by a 24-hour urinary dosage of norepinephrine. The (123)I-mIBG scintigraphy showed a high uptake of (123)I-mIBG in the left adrenal gland and, additionally, the single photon emission computed tomography combined with a low-dose CT (SPECT/CT) suggested the extension into the adrenal vein. The diagnostic CT and magnetic resonance images agreed with these findings and the subsequent surgery confirmed the vascular invasion...
October 13, 2016: Acta Chirurgica Belgica
Jan Müller, Robin Reichel, Sebastian Vogt, Stefan P Müller, Wolfgang Sauerwein, Wolfgang Brandau, Angelika Eggert, Alexander Schramm
Neuroectodermal tumours are characterized by aberrant processing of disialogangliosides concomitant with high expression of GD2 or GD3 on cell surfaces. Antibodies targeting GD2 are already in clinical use for therapy of neuroblastoma, a solid tumour of early childhood. Here, we set out to identify peptides with high affinity to human disialoganglioside GD2. To this end, we performed a combined in vivo and in vitro screen using a recombinant phage displayed peptide library. We isolated a phage displaying the peptide sequence WHWRLPS that specifically binds to the human disialoganglioside GD2...
2016: PloS One
Shunsuke Tamaki, Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Tsutomu Kawai, Satoshi Takahashi, Masashi Ishimi, Hideyuki Hakui, Tatsuhisa Ozaki, Yoshihiro Sato, Masahiro Seo, Yasushi Sakata, Masatake Fukunami
AIMS: Right ventricular (RV) systolic dysfunction has been shown to be an independent predictor of clinical outcome in patients with chronic heart failure (CHF), and cardiac metaiodobenzylguanidine (MIBG) imaging also provides prognostic information. We aimed to evaluate the long-term predictive value of combining RV systolic dysfunction and abnormal findings of cardiac MIBG imaging on outcome in CHF patients. METHODS AND RESULTS: We enrolled 63 CHF outpatients with left ventricular ejection fraction (EF) <40% in a prospective cohort study...
December 2015: ESC Heart Failure
Maria Salsone, Rita Nistico', Basilio Vescio, Fabiana Novellino, Maurizio Morelli, Angela Lupo, Gennarina Arabia, Aldo Quattrone
OBJECTIVE: To investigate heart rate variability (HRV) in patients with Essential Tremor (ET) in comparison with patients with Parkinson's Disease (PD). METHODS: This is a cross sectional control study including 10 patients with ET, 10 patients with PD and 10 age-sex-matched controls. In patients and controls, we measured the components of HRV analysis in the frequency domain during a daytime period of 12-h. Selected HRV variables were low-frequency (LF) and high-frequency (HF), conventionally considered to be influenced by the sympathetic system and the parasympathetic system respectively...
September 28, 2016: Parkinsonism & related Disorders
Kenichi Nakajima, Masahito Yamada
(123)I-meta-iodobenzylguanidine (MIBG) has become widely applied in Japan since its introduction to clinical cardiology and neurology practice in the 1990s. Neurological studies found decreased cardiac uptake of (123)I-MIBG in Lewy-body diseases including Parkinson's disease and dementia with Lewy bodies. Thus, cardiac MIBG uptake is now considered a biomarker of Lewy body diseases. Although scintigraphic images of (123)I-MIBG can be visually interpreted, an average count ratio of heart-to-mediastinum (H/M) has commonly served as a semi-quantitative marker of sympathetic activity...
September 2016: Chonnam Medical Journal
D O Verschure, B L F van Eck-Smit, G A Somsen, R J J Knol, H J Verberne
Heart failure is a life-threatening disease with a growing incidence in the Netherlands. This growing incidence is related to increased life expectancy, improvement of survival after myocardial infarction and better treatment options for heart failure. As a consequence, the costs related to heart failure care will increase. Despite huge improvements in treatment, the prognosis remains unfavourable with high one-year mortality rates. The introduction of implantable devices such as implantable cardioverter defibrillators (ICD) and cardiac resynchronisation therapy (CRT) has improved the overall survival of patients with chronic heart failure...
September 27, 2016: Netherlands Heart Journal
V Lewington, B Lambert, U Poetschger, Z Bar Sever, F Giammarile, A J B McEwan, Rita Castellani, T Lynch, B Shulkin, M Drobics, A Staudenherz, R Ladenstein
PURPOSE: A robust method is required to standardise objective reporting of diagnostic (123)I-mIBG images in neuroblastoma. Prerequisites for an appropriate system are low inter- and intra-observer error and reproducibility across a broad disease spectrum. We present a new reporting method, developed and tested for SIOPEN by an international expert panel. METHOD: Patterns of abnormal skeletal (123)I-mIBG uptake were defined and assigned numerical scores [0-6] based on disease extent within 12 body segments...
September 24, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Fahad Waqar, Hina K Jamali, Myron C Gerson
No abstract text is available yet for this article.
September 8, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Arthur J H A Scholte
No abstract text is available yet for this article.
September 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Tetsuhide Ito, Lingaku Lee, Robert T Jensen
INTRODUCTION: Neuroendocrine tumors(NETs), once thought rare, are increasing in frequency in most countries and receiving increasing-attention. NETs present two-treatment problems. A proportion is aggressive and a proportion has a functional, hormone-excess-state(F-NET) each of which, must be treated. Recently, there have been many advances, well-covered in reviews/consensus papers on imaging-NETs; new, novel anti-tumor treatments and understanding their pathogenesis. However, little attention has been paid to advances in the treatment of the hormone-excess-state...
September 16, 2016: Expert Opinion on Pharmacotherapy
James T Thackeray, Frank M Bengel
The autonomic nervous system is the primary extrinsic control of heart rate and contractility, and is subject to adaptive and maladaptive changes in cardiovascular disease. Consequently, noninvasive assessment of neuronal activity and function is an attractive target for molecular imaging. A myriad of targeted radiotracers have been developed over the last 25 years for imaging various components of the sympathetic and parasympathetic signal cascades. While routine clinical use remains somewhat limited, a number of larger scale studies in recent years have supplied momentum to molecular imaging of autonomic signaling...
December 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Ryusuke Nakamoto, Yuji Nakamoto, Takayoshi Ishimori, Kaori Togashi
PURPOSE: This retrospective study compared the diagnostic performances of quantitative versus visual analyses of I-MIBG scintigraphy in patients with suspected pheochromocytoma and paraganglioma (PPGL). MATERIALS AND METHODS: SPECT images were obtained 6 and/or 24 h after MIBG injection from 68 patients with clinically suspected PPGL, with attenuation correction by low-dose unenhanced CT. Planar images were also obtained at each time point. SUVs of retroperitoneal tumors, including PPGLs, and physiological uptake by normal organs were measured using the SPECT images...
November 2016: Clinical Nuclear Medicine
Alessandra Bacca, Angela Pucci, Daniele Lorenzini, Serena Chiacchio, Duccio Volterrani, Mauro Ferrari, Stefano Sellari Franceschini, Gabriele Materazzi, Fulvio Basolo, Giampaolo Bernini
BACKGROUND: The expression of vesicular catecholamine transporters (VMAT1 and 2) in pheochromocytomas (PHEOs) and paragangliomas (PGLs) and the possible relationships with [18F]FDOPA PET/CT and [123I]MIBG scintigraphy uptake are unknown. Our purpose was to investigate possible correlations of either VMAT1 and VMAT2 expression with the functional imaging in patients with PHEOs and PGLs. METHODS: An observational 3-year time study was performed by enrolling 31 consecutive patients with PHEO (n=17) or PGL (n= 14)...
September 2, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Antonios Ziakas, Dimitrios Petroglou, Efstratios Moralidis, Konstantinos Tsioufis, Mihalis Doumas, Elena Argiriadou, Christos Savopoulos, Stavros Hadjimiltiades, Ioannis Stiliadis, Antonios Kouparanis, Sotirios Katranas, Leonidas Lillis, Athanasios Koutsakis, Haralambos Karvounis
BACKGROUND: The Symplicity-HTN 3 trial failed to show significant difference in blood pressure (BP) lowering between patients undergoing catheter-based renal denervation (RDN) and the sham-procedure arm of the study. However, there is still optimism about the role of RDN in the treatment of resistant hypertension, because identification of patients with increased sympathetic activity thus being good RDN responders, improvements in the RDN procedure and new technology RDN catheters are all expected to lead to better RDN results...
2016: Open Cardiovascular Medicine Journal
Kelly E Huibregtse, Kieuhoa T Vo, Steven G DuBois, Stephanie Fetzko, John Neuhaus, Vandana Batra, John M Maris, Brian Weiss, Araz Marachelian, Greg A Yanik, Katherine K Matthay
Several reports of second malignant neoplasm (SMN) in patients with relapsed neuroblastoma after treatment with (131)I-MIBG suggest the possibility of increased risk. Incidence of and risk factors for SMN after (131)I-MIBG have not been defined. This is a multi-institutional retrospective review of patients with neuroblastoma treated with (131)I-MIBG therapy. A competing risk approach was used to calculate the cumulative incidence of SMN from time of first exposure to (131)I-MIBG. A competing risk regression was used to identify potential risk factors for SMN...
October 2016: European Journal of Cancer
Diana Paez, Amalia Peix, Pilar Orellana, Joao Vitola, Fernando Mut, Claudia Gutiérrez, Crosby Plaza, Tarik Becic, Maurizio Dondi, Enrique Estrada
The burden of cardiovascular diseases (CVDs) in the world is ever growing. They represent the first cause of death worldwide and in Latin America. Nuclear cardiology has a well-established role in the management of patient with CVDs and is being increasingly integrated into the healthcare systems in the region. However, there remains variability as to the infrastructure available across the countries, in terms of existing technology, radiopharmaceuticals, and human resources. The approximate number of gamma (γ) cameras in the region is 1348, with an average of 2...
August 29, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Romain Clerc, Sophia Doll, Laurent M Riou, Pascale Perret, Alexis Broisat, Audrey Soubies, Marie-Dominique Desruet, Daniel Fagret, Carole Schwebel, Catherine Ghezzi
BACKGROUND: Sympathetic system abnormalities have been reported in sepsis-related cardiac dysfunction. The present study aimed at evaluating the potential of the norepinephrine radiolabeled analogue [(123)I]-meta-iodobenzylguanidine ((123)I-MIBG) for the noninvasive assessment of modifications in cardiac sympathetic activity occurring in lipopolysaccharide (LPS)-induced experimental acute sepsis by single-photon emission computed tomographic imaging (SPECT). METHODS AND RESULTS: Sepsis was induced in male Wistar rats by intraperitoneal injection of 10 mg·kg(-1) lipopolysaccharide (n = 16), whereas control animals (n = 7) were injected with vehicle (NaCl 0...
August 29, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
David A Edmondson, Erin E Karski, Ayano Kohlgruber, Harsha Koneru, Katherine K Matthay, Shelly Allen, Christine L Hartmann, Leif E Peterson, Steven G DuBois, Matthew A Coleman
Calculating internal dose from therapeutic radionuclides currently relies on estimates made from multiple radiation exposure measurements, converted to absorbed dose in specific organs using the Medical Internal Radiation Dose (MIRD) schema. As an alternative biodosimetric approach, we utilized gene expression analysis of whole blood from patients receiving targeted radiotherapy. Collected blood from patients with relapsed or refractory neuroblastoma who received (131)I-labeled metaiodobenzylguanidine ((131)I-mIBG) at the University of California San Francisco (UCSF) was used to compare calculated internal dose with the modulation of chosen gene expression...
September 2016: Radiation Research
Fabien Vauchot, Fayçal Ben Bouallègue, Christophe Hedon, Christophe Piot, François Roubille, Denis Mariano-Goulart
BACKGROUND: Assessment of the area at risk (AAR) associated with an acute myocardial infarction is crucial for evaluating prevention and revascularization strategies. The aim of this study was to evaluate whether (123)I-metaiodobenzylguanidine ((123)I-MIBG) single-photon emission computed tomography (SPECT) provides a more widely available assessment of anatomical AAR than the established anatomical angiographic methods. METHODS: Seventy patients with ST-segment elevation acute myocardial infarction (STEMI) underwent coronary angiography with percutaneous coronary intervention and subsequent (123)I-MIBG myocardial scintigraphy with left myocardial relative radiotracer uptake evaluation 12 ± 10 days after STEMI...
August 22, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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