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https://www.readbyqxmd.com/read/28808889/interactions-between-myocardial-sympathetic-denervation-and-left-ventricular-mechanical-dyssynchrony-a-czt-analysis
#1
Alessia Gimelli, Riccardo Liga, Francesca Menichetti, Ezio Soldati, Maria Grazia Bongiorni, Paolo Marzullo
BACKGROUND: A correlation between left ventricular (LV) dyssynchrony (LVD) and impaired myocardial sympathetic tone has been hypothesized. We sought to assess the interactions between regional LV sympathetic innervation, perfusion, and mechanical dyssynchrony. METHODS: Eighty-three patients underwent evaluation of LV perfusion and sympathetic innervation on (99m)Tc-tetrofosmin/(123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging. The summed rest score and summed (123)I-MIBG score (SS-MIBG) were computed...
August 14, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28808732/individualized-risk-assessment-in-neuroblastoma-does-the-tumoral-metabolic-activity-on-123-i-mibg-spect-predict-the-outcome
#2
Julian M M Rogasch, Patrick Hundsdoerfer, Christian Furth, Florian Wedel, Frank Hofheinz, Paul-Christian Krüger, Holger Lode, Winfried Brenner, Angelika Eggert, Holger Amthauer, Imke Schatka
PURPOSE: Risk-adapted treatment in children with neuroblastoma (NB) is based on clinical and genetic factors. This study evaluated the metabolic tumour volume (MTV) and its asphericity (ASP) in pretherapeutic (123)I-MIBG SPECT for individualized image-based prediction of outcome. METHODS: This retrospective study included 23 children (11 girls, 12 boys; median age 1.8 years, range 0.3-6.8 years) with newly diagnosed NB consecutively examined with pretherapeutic (123)I-MIBG SPECT...
August 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28806253/variable-mibg-activity-in-the-same-renal-cyst
#3
Xiaofei Zhao, Hongming Zhuang
A series of I-MIBG scanning was performed in a 33-year-old woman with a history of ganglioneuroblastoma and a known left renal cyst. The initial studies did not reveal any MIBG activity in the renal cyst. However, increased MIBG activity was noted in the same renal cyst in the subsequent follow-up scans.
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28759518/assessment-of-organ-dosimetry-for-planning-repeat-treatments-of-high-dose-131i-mibg-therapy-123i-mibg-versus-posttherapy-131i-mibg-imaging
#4
Neeta Pandit-Taskar, Pat Zanzonico, Patrick Hilden, Irina Ostrovnaya, Jorge A Carrasquillo, Shakeel Modak
PURPOSE: To evaluate detailed organ-based radiation-absorbed dose for planning double high-dose treatment with I-MIBG. METHODS: In a prospective study, 33 patients with high-risk refractory or recurrent neuroblastoma were treated with high-dose I-MIBG. Organ dosimetry was estimated from the first I-MIBG posttherapy imaging and from subsequent I-MIBG imaging prior to the planned second administration. Three serial whole-body scans were performed per patient 2 to 6 days after I-MIBG therapy (666 MBq/kg or 18 mCi/kg) and approximately 0...
July 29, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28748315/interferon-alpha-treatment-for-disease-control-in-metastatic-pheochromocytoma-paraganglioma-patients
#5
Julien Hadoux, Marie Terroir, Sophie Leboulleux, Frederic Deschamps, Abir Al Ghuzlan, Ségolène Hescot, Lambros Tselikas, Isabelle Borget, Caroline Caramella, Desirée Déandréis, Diane Goere, Thierry De Baere, Martin Schlumberger, Eric Baudin
Interferon-alpha (IFN-alpha) is recommended in neuroendocrine tumors (NET). Malignant pheochromocytoma and paragangliomas (MPPGLs) constitute a rare subgroup of NET with few treatment options. IFN-alpha efficacy in patients with MPPGLs was evaluated in a single-center retrospective study. Progression-free survival (PFS) was the primary endpoint according to RECIST 1.1 and/or PERCIST 1.0, and response rate, safety, and symptomatic efficacy were secondary endpoints. Fourteen patients received peginterferon alfa-2a (90 to 180 μg/week) or interferon alfa-2b (1...
July 26, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28733764/cardiac-sympathetic-neuronal-damage-precedes-myocardial-fibrosis-in-patients-with-anderson-fabry-disease
#6
Massimo Imbriaco, Teresa Pellegrino, Valentina Piscopo, Mario Petretta, Andrea Ponsiglione, Carmela Nappi, Marta Puglia, Serena Dell'Aversana, Eleonora Riccio, Letizia Spinelli, Antonio Pisani, Alberto Cuocolo
PURPOSE: Cardiac sympathetic denervation may be detectable in patients with Anderson-Fabry disease (AFD), suggesting its usefulness for early detection of the disease. However, the relationship between sympathetic neuronal damage measured by (123)I-metaiodobenzylguanidine (MIBG) imaging with myocardial fibrosis on cardiac magnetic resonance (CMR) is still unclear. METHODS: Cardiac sympathetic innervation was assessed by (123)I-MIBG single-photon emission computed tomography (SPECT) in 25 patients with genetically proved AFD...
July 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28705916/biodistribution-and-dosimetry-of-18-f-meta-fluorobenzyl-guanidine-mfbg-a-first-in-human-pet-ct-imaging-study-of-patients-with-neuroendocrine-malignancies
#7
Neeta Pandit-Taskar, Pat B Zanzonico, Kevin D Staton, Jorge A Carrasquillo, Diane Reidy-Lagunes, Serge K Lyashchenko, Eva Burnazi, Hanwen Zhang, Jason S Lewis, Ronald Blasberg, Steven M Larson, Wolfgang Andreas Weber, Shakeel Modak
Introduction: Iodine-123-meta-iodobenzylguanidine ((123)I-MIBG) imaging is currently a mainstay in the evaluation of many neuroendocrine tumors, especially neuroblastoma. (123)I-MIBG imaging has several limitations that can be overcome by the use of a PET agent. (18)F-MFBG is a positron emission tomography (PET) analog of MIBG that may allow for single-day, high-resolution quantitative imaging. We conducted a first-in-human study of (18)F-MFBG PET imaging to evaluate the safety, feasibility, pharmacokinetics, and dosimetry of (18)F-MFBG in neuroendocrine tumors (NETs)...
July 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28689357/cross-calibration-of-123-i-meta-iodobenzylguanidine-heart-to-mediastinum-ratio-with-d-spect-planogram-and-anger-camera
#8
Kenichi Nakajima, Koichi Okuda, Kunihiko Yokoyama, Tatsuya Yoneyama, Shiro Tsuji, Hiroyuki Oda, Mitsuhiro Yoshita, Koji Kubota
BACKGROUND: Cardiac (123)I-meta-iodobenzylguanidine (MIBG) uptake is quantified using the heart-to-mediastinum ratio (HMR) with an Anger camera. The relationship between HMR determined using D-SPECT with a cadmium-zinc-telluride detector and an Anger camera is not fully understood. Therefore, the present study aimed to define this relationship using images derived from a phantom and from patients. METHODS: Cross-calibration phantom studies using an Anger camera with a low-energy high-resolution (LEHR) collimator and D-SPECT, and clinical (123)I-MIBG studies proceeded in 40 consecutive patients (80 studies)...
July 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28689103/-123-i-meta-iodobenzylguanidine-mibg-myocardial-scintigraphy-in-patients-showing-scans-without-evidence-of-dopaminergic-deficits-swedds
#9
Fumihito Yoshii, Yusuke Moriya, Tomohide Ohnuki, Masafuchi Ryo, Wakoh Takahashi, Saori Kohara, Jun Hashimoto
OBJECTIVE: Scans without evidence of dopaminergic deficits (SWEDDs) in dopamine transporter single-photon emission computed tomography (DAT-SPECT) are found in 3.6-19.6% of patients with clinically suspected Parkinson's disease (PD). We investigated whether combined use of (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy would be helpful to differentiate PD among SWEDDs patients. PATIENTS AND METHODS: 145 patients with clinically suspected PD underwent both DAT-SPECT and MIBG myocardial scintigraphy...
September 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28688242/abnormal-renal-parenchyma-accumulation-of-123-i-mibg-in-a-child-with-renal-artery-stenosis
#10
Randy Yeh, Ahmed Mohammed, Aleksandr Margolin, Peter Schlossberg, Rama S Ayyala
Hypertension is rare in the pediatric population, however renal artery stenosis (RAS) is an important cause that can be difficult to diagnose. Doppler ultrasound is the first line imaging modality, with computed tomography and magnetic resonance imaging as adjunct modalities, all with variable sensitivity for RAS. The gold standard for evaluation of RAS is invasive selective catheter angiography. We present a unique multimodality case of abnormal radiotracer uptake in the renal parenchyma on 123-Iodine metaiodobenzylguanidine ((123)I MIBG) scan in a patient with unilateral RAS...
July 3, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28685506/update-on-modern-management-of-pheochromocytoma-and-paraganglioma
#11
REVIEW
Jacques W M Lenders, Graeme Eisenhofer
Despite all technical progress in modern diagnostic methods and treatment modalities of pheochromocytoma/paraganglioma, early consideration of the presence of these tumors remains the pivotal link towards the best possible outcome for patients. A timely diagnosis and proper treatment can prevent the wide variety of potentially catastrophic cardiovascular complications. Modern biochemical testing should include tests that offer the best available diagnostic performance, measurements of metanephrines and 3-methoxytyramine in plasma or urine...
June 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28681337/assessing-arrhythmic-risk-with-123-i-mibg-and-analogous-tracers-image-interpretation-from-a-different-viewpoint
#12
EDITORIAL
Mark I Travin
No abstract text is available yet for this article.
July 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28677058/structural-changes-in-parkinson-s-disease-voxel-based-morphometry-and-diffusion-tensor-imaging-analyses-based-on-123-i-mibg-uptake
#13
Kazufumi Kikuchi, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Ryo Somehara, Ryotaro Kamei, Shingo Baba, Hiroo Yamaguchi, Jun-Ichi Kira, Hiroshi Honda
OBJECTIVE: Patients with Parkinson's disease (PD) may exhibit symptoms of sympathetic dysfunction that can be measured using (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy. We investigated the relationship between microstructural brain changes and (123)I-MIBG uptake in patients with PD using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) analyses. METHODS: This retrospective study included 24 patients with PD who underwent 3 T magnetic resonance imaging and (123)I-MIBG scintigraphy...
July 4, 2017: European Radiology
https://www.readbyqxmd.com/read/28670690/possible-involvement-of-hypotension-in-postprandial-headache-a-case-series
#14
Tsubasa Takizawa, Mamoru Shibata, Takahiro Hiraide, Morinobu Seki, Shinichi Takahashi, Norihiro Suzuki
BACKGROUND: It is commonly known that headaches are induced by intake of specific food, drink, and/or additive. In addition, some patients experience postprandial headache independent of ingestion of specific items. Currently, information on the pathophysiology underlying this particular type of headache is scarce. CASE REPORTS: We report two cases in which headaches were observed after each meal. Postprandial hypotension was demonstrated in both cases. Tonometry-based continuous blood pressure measurement during head-up tilt revealed sympathetic dysfunction...
July 3, 2017: Headache
https://www.readbyqxmd.com/read/28650885/aggressive-imaging-features-in-a-malignant-pheochromocytoma-with-a-novel-mutation-of-the-sdhb-gene
#15
Soon-Ah Park, Dae Ho Lee, Hun Soo Kim
We describe a 15-year-old boy with a huge bilateral adrenal pheochromocytoma that had a de novo germline mutation in the succinate dehydrogenase subunit B (SDHB) gene. F-FDG PET/CT revealed bilateral metabolically active large masses in the adrenal glands and the activated brown adipose tissues. The I-MIBG scintigraphic findings revealed only a mild accumulation of MIBG in the right adrenal mass, but a high uptake in the left adrenal mass. Thus, F-FDG PET/CT imaging may be more effective than I-MIBG scintigraphy for the evaluation of pheochromocytomas that are associated with highly malignant characteristics resulting from mutations of the SDHB gene...
September 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28649613/early-onset-parkinsonism-in-a-pedigree-with-phosphoglycerate-kinase-deficiency-and-a-heterozygous-carrier-do-pgk-1-mutations-contribute-to-vulnerability-to-parkinsonism
#16
Satoshi Sakaue, Takashi Kasai, Ikuko Mizuta, Masaya Suematsu, Shinya Osone, Yumiko Azuma, Toshihiko Imamura, Takahiko Tokuda, Hitoshi Kanno, Omar M A El-Agnaf, Masafumi Morimoto, Masanori Nakagawa, Hajime Hosoi, Toshiki Mizuno
Phosphoglycerate kinase 1 (PGK-1) is a glycolytic enzyme encoded by PGK-1, which maps to the X chromosome. PGK-1 deficiency causes X-linked recessive hereditary chronic hemolytic anemia, myopathy, and neurological disorders due to insufficient ATP regeneration. Early-onset parkinsonism has occasionally been reported as a neurological complication of this condition. However, heterozygous carriers of PGK-1 deficiency were thought to be neurologically asymptomatic. Here, we report a boy with PGK-1 deficiency and his mother, a carrier of a heterozygous mutation in PGK-1, both of whom presented with early-onset parkinsonism...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/28646015/determination-of-the-heart-to-mediastinum-ratio-of-123-i-mibg-uptake-using-dual-isotope-123-i-mibg-99m-tc-tetrofosmin-multi-pinhole-czt-spect-in-patients-with-heart-failure
#17
Tanguy Blaire, Alban Bailliez, Fayçal Ben Bouallègue, Dimitri Bellevre, Denis Agostini, Alain Manrique
The aim of this retrospective study was to determine the heart-to-mediastinum ratio (HMR) of (123)I-metaiodobenzylguanidine (MIBG) uptake obtained using a multi-pinhole cadmium-zinc-telluride (CZT)-based camera (Discovery NM 530c, DNM-530c, GE Healthcare, Milwaukee, WI, USA) in comparison with that obtained using conventional planar imaging (Infinia, GE Healthcare, Milwaukee, WI, USA). Methods: Forty consecutive heart failure patients underwent planar acquisition 4 h after (123)I-MIBG injection (191±41 MBq)...
June 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28632699/inadvertent-arterial-injection-of-123i-mibg-does-not-necessarily-cause-any-symptoms
#18
Wei Zhang, Hongming Zhuang
An 123I-MIBG scan was obtained to evaluate a right adrenal mass in a 10-year-old boy, which showed no elevated activity in the lesion. However, diffuse increased activity was noted in the right forearm with typical manifestation of an "arterial injection." Different from a prior case report, no symptoms or signs related to arterial injection were observed in our patient.
September 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28625940/prodromal-stage-of-disease-dementia-with-lewy-bodies-how-to-diagnose-in-practice
#19
Frédéric Blanc, Marc Verny
Disease with Lewy bodies or dementia with Lewy bodies (DLB), particularly at the prodromal stage, is a complex disease to diagnose because of different clinical beginnings and variable paths in terms of clinical expression. Thus DLB can be entcountered in different input modes: mild cognitive impairment, depression, acute behavioral disorders, confusion and delirium, or sleep disorders. In the aim to better diagnose the disease, should be sought obviously to search for the key symptoms: fluctuations, hallucinations, extra-pyramidal syndrome, and REM sleep behavior disorder...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28605448/efficacy-of-peptide-receptor-radionuclide-therapy-prrt-for-functional-metastatic-paraganglioma-and-phaeochromocytoma
#20
Grace Kong, Simona Grozinsky-Glasberg, Michael S Hofman, Jason Callahan, Amichay Meirovitz, Ofra Maimon, David A Pattison, David J Gross, Rodney J Hicks
Purpose: Treatment options for unresectable Paraganglioma (PGL)/Phaeochromocytoma (PCC), especially with uncontrolled secondary hypertension (HTN) are limited. Preliminary studies with PRRT suggest efficacy but data on HTN control and survival are lacking. We assessed PRRT outcomes in such patients from 2 referral centres. Methods: 20 consecutive patients (M:F=13:7; 21-77y.o.) with high somatostatin receptor (SSTR) expression treated with 177Lu-DOTA-octreotate, 9 with radiosensitising chemotherapy, were retrospectively reviewed...
June 9, 2017: Journal of Clinical Endocrinology and Metabolism
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