keyword
MENU ▼
Read by QxMD icon Read
search

MIBG

keyword
https://www.readbyqxmd.com/read/29154422/beta-blocker-dose-and-markers-of-sympathetic-activation-in-heart-failure-patients-interrelationships-and-prognostic-significance
#1
Alain Cohen-Solal, Arnold F Jacobson, Ileana L Piña
AIMS: Extent of cardiac sympathetic activation can be estimated from physiological parameters, blood biomarkers, and imaging findings. This study examined the prognostic value of three markers of sympathetic activity and their relationship to beta blocker dose in heart failure patients. METHODS AND RESULTS: A post hoc analysis of 858 heart failure subjects in the ADMIRE-HF trial was performed. Variables related to sympathetic activity were plasma norepinephrine, baseline heart rate, the heart to mediastinum (H/M) ratio of (123) I-mIBG uptake, and beta blocker dose...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29127250/malignant-peripheral-nerve-sheath-tumours-of-the-pericardium-in-a-patient-with-neurofibromatosis-type-1-the-diagnostic-value-of-18f-fdg-pet-ct-and-i-123-mibg-spect-ct
#2
Mathieu Charest, Josephine Pressacco, Jaramie Thomas-Gittens
A 25 year old female with known neurofibromatosis type 1 with a large anterior mediastinal mass was investigated. F18-FDG PET-CT revealed a radiotracer avid anterior mediastinal mass with SUVmax of 4.3 and demonstrating a hypoactive center. The Iodine-123 MIBG SPECT-CT study performed subsequently did not demonstrate any uptake, thereby excluding for the most part the diagnoses of paraganglioma or neuroblastoma. At final pathology, a malignant peripheral nerve sheath tumour (MPNST) of the pericardium with areas of chondrosarcomatous and angiosarcomatous differentiation was diagnosed...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29112909/potential-diagnostic-value-of-131-i-mibg-myocardial-scintigraphy-in-discrimination-between-alzheimer-disease-and-dementia-with-lewy-bodies
#3
Mehrshad Abbasi, Nafise Ghalandari, Saeed Farzanefar, Vajiheh Aghamollaii, Mona Ahmadi, Morsaleh Ganji, Mohsen Afarideh, Sogol Loloee, Maryam Naseri, Abbas Tafakhori
OBJECTIVES: Clinical difficulty to discriminate between the Alzheimer disease (AD) and dementia with Lewy bodies (DLB) has led researchers to focus on highly sensitive functional imaging modalities. The aim of the present study was to assess (131)I-MIBG cardiac imaging to distinguish between AD and DLB. PATIENTS AND METHODS: Seventeen patients who were known cases of dementia underwent (131)I-MIBG myocardial scintigraphy to differentiate AD from DLB. Planar and (131)I-MIBG SPECT were obtained 2h after the injection of 1mCi (131)I-MIBG on a dual head gamma camera...
October 25, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29107753/bladder-wall-paranganglioma-located-using-123-i-mibg-spect-and-ct-imaging
#4
Viviana Frantellizzi, Mariano Pontico, Claudio Letizia, Giuseppe De Vincentis
No abstract text is available yet for this article.
October 26, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29099942/phase-1-study-of-high-specific-activity-i-131-mibg-for-metastatic-and-or-recurrent-pheochromocytoma-or-paraganglioma
#5
Richard B Noto, Daniel A Pryma, Jessica Jensen, Tess Lin, Nancy Stambler, Thomas Strack, Vivien Wong, Stanley J Goldsmith
Context: There are no approved therapies for the treatment of metastatic and/or recurrent pheochromocytoma or paraganglioma (PPGL) in the United States. Objective: To determine the maximum tolerated dose (MTD) of high-specific-activity I-131 meta-iodobenzylguanidine (MIBG) for the treatment of metastatic and/or recurrent PPGL. Design: Phase 1, dose escalating study to determine the MTD via a standard 3+3 design; escalating by 37 MBq/kg starting at 222 MBq/kg...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29097943/correlation-of-somatostatin-receptor-2-expression-with-gallium-68-dota-tate-uptake-in-neuroblastoma-xenograft-models
#6
Libo Zhang, Douglass C Vines, Deborah A Scollard, Trevor McKee, Teesha Komal, Milan Ganguly, Trevor Do, Bing Wu, Natasha Alexander, Reza Vali, Amer Shammas, Travis Besanger, Sylvain Baruchel
Peptide-receptor imaging and therapy with radiolabeled somatostatin analogs such as (68)Ga-DOTA-TATE and (177)Lu-DOTA-TATE have become an effective treatment option for SSTR-positive neuroendocrine tumors. The purpose of this study was to evaluate the correlation of somatostatin receptor-2 (SSTR2) expression with (68)Ga-DOTA-TATE uptake and (177)Lu-DOTA-TATE therapy in neuroblastoma (NB) xenograft models. We demonstrated variable SSTR2 expression profiles in eight NB cell lines. From micro-PET imaging and autoradiography, a higher uptake of (68)Ga-DOTA-TATE was observed in SSTR2 high-expressing NB xenografts (CHLA-15) compared to SSTR2 low-expressing NB xenografts (SK-N-BE(2))...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29058276/comparison-of-diagnosing-and-staging-accuracy-of-pet-ct-and-mibg-on-patients-with-neuroblastoma-systemic-review-and-meta-analysis
#7
Jia Xia, Hang Zhang, Qun Hu, Shuang-You Liu, Liu-Qing Zhang, Ai Zhang, Xiao-Ling Zhang, Ya-Qin Wang, Ai-Guo Liu
To perform a systemic review and meta-analysis of the diagnostic accuracy of PET (CT) and metaiodobenzylguanidine (MIBG) for diagnosing neuroblastoma (NB), electronic databases were searched as well as relevant references and conference proceedings. The diagnostic accuracy of MIBG and PET (CT) was calculated for NB, primary NB, and relapse/metastasis of NB based on their sensitivity, specificity, and area under the summary receiver operating characteristic curve (AUSROC) in terms of per-lesion and per-patient data...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29050867/acute-type-a-aortic-dissection-in-a-patient-with-paraganglioma
#8
Andreia Dos Santos Borrego, Pedro Carrilho Ferreira, Fausto J Pinto
Acute aortic dissection is the most common acute aortic syndrome. It is more prevalent in males and in the elderly, and has a high mortality. Hypertension is the main risk factor. Diagnosis is based on clinical features, laboratory tests and imaging exams. Treatment is usually surgical, although in some cases an endovascular approach is an alternative. Paraganglioma is an uncommon neuroendocrine tumor. Most produce catecholamines, and so usually manifest with hypertensive crisis, palpitations, headache and sweating...
October 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29042467/variability-in-heart-to-mediastinum-ratio-from-planar-123-i-mibg-images-of-a-thorax-phantom-for-6-common-gamma-camera-models
#9
Rikard Owenius, Michelle Zanette, Patrick Cella
A heart-to-mediastinum (H/M) ratio ≥1.6 on planar Iobenguane (123)I ((123)I-mIBG; AdreView) images identifies heart failure patients at low risk of experiencing an adverse cardiac event. This phase 4 study used standardized phantoms to assess the inter-camera, intra-camera, and inter-head variability in H/M ratio determinations from planar cardiac (123)I-mIBG imaging using commercially-available, dual-head gamma cameras. Methods: A fillable thorax phantom was developed to simulate the typical uptake of (123)I-mIBG...
October 17, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29033831/accumulation-of-123-i-ioflupane-is-a-useful-marker-of-the-efficacy-of-selegiline-monotherapy-in-drug-na%C3%A3-ve-parkinson-s-disease
#10
Hidetomo Murakami, Tetsuhito Nohara, Masanobu Uchiyama, Yoshiyuki Owan, Akinori Futamura, Azusa Shiromaru, Setsuro Tsukada, Yu Saito, Takeshi Kuroda, Satoshi Yano, Seiichiro Ishigaki, Hirotaka Katoh, Jiro Munechika, Yoshimitsu Ohgiya, Takehiko Gokan, Kenjiro Ono
Background: Selegiline enhances the patient's endogenous dopamine by inhibiting dopamine metabolism. The efficacy of selegiline monotherapy for drug-naïve Parkinson's disease (PD) patients may depend on the degree of dopaminergic neuronal degeneration. (123)I-Ioflupane single photon emission computed tomography (SPECT) and (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy are diagnostic methods to assess the pharmacological and pathological changes in PD. Objective: We examined the utility of these imaging methods to predict the efficacy of selegiline monotherapy for motor symptoms in drug-naïve PD patients...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28994458/a-blind-deconvolution-method-incorporated-with-anatomical-based-filtering-for-partial-volume-correction-validations-with-123-i-mibg-cardiac-spect-ct
#11
Jing Wu, Hui Liu, Taraneh Hashemi Zonouz, Veronica M Sandoval, Hassan Mohy-Ud-Din, Rachel Lampert, Albert J Sinusas, Chi Liu, Yi-Hwa Liu
PURPOSE: Segmentation of contrast-enhanced CT and measurement of SPECT point spread function (PSF) are usually required for conventional partial volume correction (PVC). This study was to develop a segmentation-free method with blind deconvolution (BD) and anatomical-based filtering for SPECT PVC. METHODS: The proposed method was implemented using an iterative BD algorithm to estimate the restored image and the PSF simultaneously. An anatomical-based filtering was implemented at each iteration to reduce Gibbs artifact and suppress noise amplification in the deconvolution process...
October 10, 2017: Medical Physics
https://www.readbyqxmd.com/read/28991700/cardiac-sympathetic-denervation-and-dementia-in-de-novo-parkinson-s-disease-a-7-year-follow-up-study
#12
Mun Hee Choi, Jung Han Yoon, Suk Woo Yong
BACKGROUND: Postganglionic cardiac sympathetic denervation is evident in patients with early-stage Parkinson's disease (PD). Cardiac iodine-123-meta-iodobenzylguanidine (MIBG) uptake is correlated with the non-motor symptoms of PD, suggesting that low cardiac MIBG uptake may reflect wider alpha-synuclein pathology. In addition, low cardiac MIBG could be related to orthostatic hypotension in PD, which may affect cognition. However, the prognostic validity of baseline MIBG scintigraphy in terms of the risk of subsequent dementia remains unclear...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28983659/cardiac-and-peripheral-vasomotor-autonomic-functions-in-late-onset-transthyretin-val30met-familial-amyloid-polyneuropathy
#13
Haruki Koike, Tomohiko Nakamura, Atsushi Hashizume, Ryoji Nishi, Shohei Ikeda, Yuichi Kawagashira, Masahiro Iijima, Masahisa Katsuno, Gen Sobue
The objective of this study was to systematically investigate cardiac and peripheral vasomotor autonomic functions in late-onset transthyretin Val30Met familial amyloid polyneuropathy (FAP ATTR Val30Met) patients from non-endemic areas. The coefficient of variation of R-R intervals (CVR-R), responses to the Valsalva manoeuvre, head-up tilt test with impedance cardiography, noradrenaline infusion test, and (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy were assessed in eight patients. Although only four patients manifested orthostatic hypotension during the head-up tilt test, CVR-R, responses to the Valsalva manoeuvre, and myocardial MIBG uptake indicated a higher prevalence of cardiac sympathetic and parasympathetic dysfunction...
November 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28976242/persistent-positive-metaiodobenzylguanidine-scans-after-autologous-peripheral-blood-stem-cell-transplantation-may-indicate-maturation-of-stage-4-neuroblastoma
#14
Yasuhiro Okamoto, Yuichi Kodama, Takuro Nishikawa, Almitra Rindiarti, Takayuki Tanabe, Shunsuke Nakagawa, Takako Yoshioka, Koji Takumi, Tatsuru Kaji, Yoshifumi Kawano
Metaiodobenzylguanidine (MIBG) scans are sensitive testing tools for neuroblastoma. Persistent positive MIBG scans in patients with stage 3 neuroblastoma have previously been found to indicate maturation rather than regression. We assessed the significance of this finding in stage 4 neuroblastoma in the present study. Fifteen consecutive pediatric patients with stage 4 neuroblastoma treated between 2004 and 2014 at the Kagoshima University Hospital were retrospectively examined. Treatment involved a combination of multiagent chemotherapy, resection, autologous peripheral blood stem cell transplantation (PBSCT), radiotherapy, and maintenance therapy with retinoic acid...
April 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/28966286/transcatheter-aortic-valve-implantation-improves-cardiac-sympathetic-nerve-activity-on-123-i-metaiodobenzylguanidine-myocardial-scintigraphy-in-severe-aortic-valve-stenosis
#15
Mitsuo Sobajima, Hiroshi Ueno, Hiroshi Onoda, Hiroyuki Kuwahara, Shuhei Tanaka, Ryuichi Ushijima, Nobuyuki Fukuda, Shigeki Yokoyama, Saori Nagura, Toshio Doi, Akio Yamashita, Kazuaki Fukahara, Hisakatsu Ito, Koichiro Kinugawa
BACKGROUND: There is a consensus that overactivation of the cardiac sympathetic nervous system (CSN) proportionately increases the severity of heart failure and is accompanied by worse prognosis. Because it is unknown whether patients with aortic valve stenosis (AS) have similar CSN activation, we investigated the effect of transcatheter aortic valve implantation (TAVI).Methods and Results:We enrolled 31 consecutive patients with AS treated by TAVI. (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy was performed at baseline and at 2 weeks after TAVI...
September 29, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28954983/a-phase-i-clinical-trial-for-131-i-meta-iodobenzylguanidine-therapy-in-patients-with-refractory-pheochromocytoma-and-paraganglioma-a-study-protocol
#16
Anri Inaki, Kenichi Yoshimura, Toshinori Murayama, Yasuhito Imai, Yoshikazu Kuribayashi, Tetsuya Higuchi, Megumi Jinguji, Tohru Shiga, Seigo Kinuya
Objective Pheochromocytoma and paraganglioma (PPGLs) are rare neuroendocrine tumors derived from the adrenal medulla or extra-adrenal paraganglioma from extra-adrenal chromaffin tissue. Although malignant PPGLs has miserable prognosis, the treatment strategy remains to be established. An internal radiation therapy using [(131)I]meta-iodobenzylguanidine ((131)I-mIBG) called MIBG therapy has been attempted as one of the systemic treatment of malignant PPGLs. The aim of this study is therefore to evaluate the safety and the efficacy of MIBG therapy for refractory PPGLs...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28940046/validation-of-the-mibg-skeletal-siopen-scoring-method-in-two-independent-high-risk-neuroblastoma-populations-the-siopen-hr-nbl1-and-cog-a3973-trials
#17
Ruth Ladenstein, Bieke Lambert, Ulrike Pötschger, Maria-Rita Castellani, Valerie Lewington, Zvi Bar-Sever, Aurore Oudoux, Anna Śliwińska, Katerina Taborska, Lorenzo Biassoni, Gregory A Yanik, Arlene Naranjo, Marguerite T Parisi, Barry L Shulkin, Helen Nadel, Michael J Gelfand, Katherine K Matthay, Julie R Park, Susan G Kreissman, Dominique Valteau-Couanet, Ariane Boubaker
BACKGROUND: Validation of the prognostic value of the SIOPEN mIBG skeletal scoring system in two independent stage 4, mIBG avid, high-risk neuroblastoma populations. RESULTS: The semi-quantitative SIOPEN score evaluates skeletal meta-iodobenzylguanidine (mIBG) uptake on a 0-6 scale in 12 anatomical regions. Evaluable mIBG scans from 216 COG-A3973 and 341 SIOPEN/HR-NBL1 trial patients were reviewed pre- and post-induction chemotherapy. The prognostic value of skeletal scores for 5-year event free survival (5 yr...
September 23, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28916622/quantification-and-determination-of-normal-123-i-meta-iodobenzylguanidine-heart-to-mediastinum-ratio-hmr-from-cardiac-spect-ct-and-correlation-with-planar-hmr
#18
Raza Alvi, Edward J Miller, Taraneh Hashemi Zonouz, Veronica Sandoval, Noor Tariq, Rachel Lampert, Albert J Sinusas, Yi-Hwa Liu
Assessment of cardiac (123)I-mIBG uptake relies on the heart-to-mediastinal ratio (HMR) derived from planar images. We have developed novel semi-automated quantitative methodologies for assessing HMR from single photon emission computed tomography (SPECT) images using a dedicated cardiac multi-pinhole SPECT/computerized tomography (CT) system and determined the lower limit of normal (LLN) SPECT-derived HMR and the correlation to planar-derived HMR. Methods: Twenty-one healthy volunteers were injected with (123)I-meta Iodobenzylguanidine ((123)I-mIBG) and imaged using two different cameras...
September 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28905088/new-horizons-in-cardiac-innervation-imaging-introduction-of-novel-18-f-labeled-pet-tracers
#19
Ryohei Kobayashi, Xinyu Chen, Rudolf A Werner, Constantin Lapa, Mehrbod S Javadi, Takahiro Higuchi
Cardiac sympathetic nervous activity can be uniquely visualized by non-invasive radionuclide imaging techniques due to the fast growing and widespread application of nuclear cardiology in the last few years. The norepinephrine analogue (123)I-meta-iodobenzylguanidine ((123)I-MIBG) is a single photon emission computed tomography (SPECT) tracer for the clinical implementation of sympathetic nervous imaging for both diagnosis and prognosis of heart failure. Meanwhile, positron emission tomography (PET) imaging has become increasingly attractive because of its higher spatial and temporal resolution compared to SPECT, which allows regional functional and dynamic kinetic analysis...
December 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28902732/multimodality-radionuclide-imaging-in-a-patient-with-hereditary-paraganglioma-pheochromocytoma-syndrome
#20
So Y Yim, Valeria M Moncayo, Francisco J Pasquel, Raghuveer K Halkar
Hereditary paraganglioma (PGL)-pheochromocytoma (PCC) syndrome is a genetic disorder caused by a mutation of the tumor suppressor gene SDHD that results in a predisposition for head and neck PGLs and PCCs. We present a case of a 33-year-old woman where F-FDG PET/CT showed areas of increased uptake in both the adrenal and cervical regions, consistent with PCCs and PGLs, respectively. Further imaging revealed that PCCs were I-MIBG avid, whereas the PGLs were In-octreotide avid. This demonstrates the varying sensitivities of different imaging modalities in regard to neuroendocrine tumors and the potential for treatment using multiple targeted therapies...
September 11, 2017: Clinical Nuclear Medicine
keyword
keyword
46966
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"