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https://www.readbyqxmd.com/read/27792825/features-of-oral-pharyngeal-and-laryngeal-lesions-in-bullous-pemphigoid
#1
Masafumi Ohki, Shigeru Kikuchi, Atsushi Ohata, Yuka Baba, Junichi Ishikawa, Hirohito Sugimoto
Bullous pemphigoid is an autoimmune bullous disease characterized by skin lesions, with or without oral lesions. The occurrence of pharyngolaryngeal lesions is very rare in affected patients. We conducted a study to investigate the characteristics of oral and pharyngolaryngeal lesions in bullous pemphigoid. Our study population was made up of 6 consecutively presenting outpatients-2 men and 4 women, aged 40 to 83 years (mean: 68.2)-who had been referred to our department over an 11-year period. Presenting symptoms included sore throat in all 6 patients and oral pain in 3...
October 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/26815761/oral-manifestations-in-kindler-syndrome-case-report-and-discussion-of-literature-findings
#2
Nathalia Mocellin Barbosa, Fernanda Visioli, Manoela Domingues Martins, Marco Antônio Trevizani Martins, Maria Cristina Munerato
Kindler syndrome is a rare genetic disorder showing some predominant clinical manifestations, for example, trauma-induced blisters, progressive poikiloderma, skin atrophy, and photosensitivity. Oral manifestations are not commonly described and can be often misdiagnosed. This report describes the case of a female patient diagnosed with Kindler syndrome showing the classical clinical features affecting the skin, in addition to oral lesions manifesting as keratotic plaques and ulcers affecting the buccal mucosa, floor of the mouth, alveolar ridge, hard palate, and soft palate...
July 2016: Special Care in Dentistry
https://www.readbyqxmd.com/read/26604545/oral-manifestations-and-dental-management-of-epidermolysis-bullosa-simplex
#3
Lisa Scheidt, Mariane Emi Sanabe, Michele Baffi Diniz
Epidermolysis bullosa (EB) is a group of hereditary chronic disorders, characterized by fragility of the skin and mucous membranes in response to minor mechanical trauma. The objective of this study was to report the case of a young girl diagnosed with epidermolysis bullosa simplex (EBS), transmitted by an autosomal dominant gene. Cutaneous findings included blisters and dystrophy following minimal friction. Recurrent blisters and vesicle formation on the hard palate were the main oral findings. In conclusion, publications concerning the oral and clinical manifestations of EBS are important for providing knowledge and an early multidisciplinary approach that prevents blister formation and improves these patients' quality of life, with the dentist playing an important role in oral health management...
September 2015: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/25889136/update-on-hand-foot-and-mouth-disease
#4
Daniel Ventarola, Lindsey Bordone, Nanette Silverberg
Hand-foot-and-mouth disease is a viral exanthem caused, primarily by Coxsackie A16 and enterovirus 71 with typical clinical features of fever, painful papules and blisters over the extremities and genitalia and an enanthem involving ulceration of the mouth, palate, and pharynx. Other enteroviruses have recently been noted to cause severe neurologic illness and paralysis (enterovirus 68) with variable cutaneous features. A recent outbreak of Coxsackie A6 infection has been seen worldwide with cases reported in the United States, Japan, Southeast Asia, and Europe...
May 2015: Clinics in Dermatology
https://www.readbyqxmd.com/read/25785208/unilateral-oral-mucous-membrane-pemphigoid-refractory-atypical-presentation-successfully-treated-with-intravenous-immunoglobulins
#5
André Laureano, Jorge Cardoso
A 57-year-old male presented with a 6-month history of blisters and painful erosions on the right buccal mucosa. No skin or other mucosal involvement was seen. The findings of histopathological and direct immunofluorescence examinations were sufficient for the diagnosis of oral mucous membrane pemphigoid in the context of adequate clinical correlation. No response was seen after topical therapies and oral corticosteroids or dapsone. Intravenous immunoglobulin was started and repeated every three weeks. Complete remission was achieved after three cycles and no recurrence was seen after two years of follow-up...
2015: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/25632365/a-case-of-oropharyngeal-bullous-pemphigoid-presenting-with-haemoptysis
#6
C M Lee, H K Leadbetter, J M Fishman
Objective. Bullous pemphigoid is well known for its cutaneous features; however in rare cases it may present with mucosal involvement. We report a case of bullous pemphigoid presenting with haemoptysis, initially presenting to the Ear, Nose and Throat Department for investigation. Methods. An 87-year-old lady was admitted with haemoptysis. She also complained of a spreading, pruritic, bullous rash, which first began three weeks previously. Initial investigations, which included nasendoscopy, revealed a normal nasal mucosa and a normal postnasal space...
2015: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/25355555/anti-bp180-type-mucous-membrane-pemphigoid-report-of-two-cases
#7
Mayumi Wada, Jun Sato, Masanobu Shindoh, Hideyuki Ujiie, Ken Natsuga, Wataru Nishie, Hiroshi Shimizu, Yoshimasa Kitagawa
We describe two patients with anti-BP180-type mucous membrane pemphigoid (MMP), who were correctly diagnosed and treated in early stages through the cooperation of dentists and dermatologists. Patient 1 was a 74-year-old woman who visited our dental department due to blisters over the oral mucosa and eruptions on the skin. She had also experienced bleeding of the gingiva and palate mucosa. Biopsy specimens from the oral mucosa revealed detachment of epithelial basement membrane and subepithelial lamina propria with slight chronic inflammation...
January 2016: Odontology
https://www.readbyqxmd.com/read/25354580/epidermolysis-bullosa-in-animals-a-review
#8
REVIEW
Gildenor X Medeiros, Franklin Riet-Correa
Epidermolysis bullosa (EB) is a hereditary mechanobullous disease of animals and humans, characterized by an extreme fragility of the skin and mucous membranes. The main feature of EB in humans and animals is the formation of blisters and erosions in response to minor mechanical trauma. Epidermolysis bullosa is caused by mutations in the genes that code for structural proteins of the cytoskeleton of the basal keratinocytes or of the basement membrane zone. Based on the ultrastructural levels of tissue separation, EB is divided into the following three broad categories: epidermolysis bullosa simplex, junctional epidermolysis bullosa and dystrophic epidermolysis bullosa...
February 2015: Veterinary Dermatology
https://www.readbyqxmd.com/read/25284524/dental-management-of-patients-with-epidermolysis-bullosa
#9
Canan Dağ, Tuğba Bezgin, Nurhan Özalp
Epidermolysis Bullosa (EB) is a group of rare, genetic skin disorders characterized by fragility and blistering to minimal trauma. All oral surfaces may be involved, including the tongue, buccal mucosa, palate, floor of the mouth and gingiva. Common oral findings of the disease include microstomia, intraoral ulcerations and bullae formation, ankyloglossia, tongue atrophy, elimination of buccal and vestibular sulci, lingual depapillation and atrophy of the palatal folds. In these case reports; systemic findings, oral manifestations and preventive measures are described for 3 patients with EB, all of whom required extensive oral management...
September 2014: Oral Health and Dental Management
https://www.readbyqxmd.com/read/25284520/evaluation-of-pemphigus-cases-involving-oral-mucosa
#10
Gizem Karagöz, Kivanç Bektaş-Kayhan, Meral Ünür
PURPOSE: Pemphigus, defines a group of disorders in autoimmune etiology which could be life-threatening and clinical manifestations are mainly epithelial blistering affecting cutaneous and/or mucosal surfaces including oral mucosa. The aim of our study is to evaluate the clinical appearance of pemphigus with oral involvement by reported 15 pemphigus cases. MATERIAL AND METHODS: This retrospective study of 15 cases of pemphigus obtained over a period of 7 years from 2006 to 2013 in Istanbul University, Dentistry Faculty, Oral Medicine and Surgery Department was designed...
September 2014: Oral Health and Dental Management
https://www.readbyqxmd.com/read/24334011/angina-bullosa-haemorrhagica
#11
Hitesh Shoor, Sunil Mutalik, Keerthilatha M Pai
A woman in her early 40s presented with a painless ulceration on the right side of the posterior palate, she had an earlier history of similar lesions after the rupturing of blood filled blisters in the oral cavity. On examination, a diffuse erythematous area and ulcers covered with necrotic slough were noticed on the right and left side of the posterior palate and on the right buccal mucosa. On follow-up visit, a large blood filled blister was noticed in the buccal vestibule. We advised routine haematological investigations to rule out any bleeding disorders and direct immunofluorescence of the affected tissue and perilesional areas to rule out autoimmune blistering conditions...
2013: BMJ Case Reports
https://www.readbyqxmd.com/read/24143185/bfb-a-novel-enu-induced-blebs-mutant-resulting-from-a-missense-mutation-in-fras1
#12
Kerry A Miller, Christopher T Gordon, Megan F Welfare, Georgina Caruana, John F Bertram, John F Bateman, Peter G Farlie
Fras1 is an extracellular matrix associated protein with essential roles in adhesion of epithelia and mesenchyme during early embryonic development. The adhesive function of Fras1 is achieved through interaction with a group of related proteins, Frem 1-3, and a cytoplasmic adaptor protein Grip1. Mutation of each of these proteins results in characteristic epithelial blistering and have therefore become known as "blebs" proteins. Human Fraser syndrome presents with a similar phenotype and the blebs mice have been instrumental in identification of the genetic basis of Fraser syndrome...
2013: PloS One
https://www.readbyqxmd.com/read/24097722/a-rare-presentation-of-oral-pemphigus-vulgaris-as-multiple-pustules
#13
J Rimal, K N Sumanth, R Ongole, T George, S Chatterjee
Pemphigus vulgaris is an autoimmune blistering disease affecting the mucous membrane and skin. Ulcers, vesicles, bulla, erosions are the common manifestations of the disease. It is uncommon to find multiple pustular lesions in the oral cavity. Here, we report the first case of multiple pustules involving the lateral borders of tongue, buccal mucosa, hard palate, soft palate, vestibule and the gingiva of a 53 year old male. Histopathologic and Immunofluoroscence study was suggestive of pemphigus vulgaris. The condition improved with systemic corticosteroid along with adjuvant therapy...
October 2007: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/23772832/patterns-of-oral-mucosa-lesions-in-patients-with-epidermolysis-bullosa-comparison-and-agreement-between-oral-medicine-and-dermatology
#14
MULTICENTER STUDY
Giulio Fortuna, Francina Lozada-Nur, Annamaria Pollio, Massimo Aria, Rodrigo Cepeda-Valdes, Matt Peter Marinkovich, Anna L Bruckner, Julio Cesar Salas-Alanís
BACKGROUND: The oral mucosa in patients with epidermolysis bullosa (EB) can be affected with different lesions and degrees of severity. However, patterns of oral lesions in distinct types of EB are still unclear. OBJECTIVES: The purpose of this study was to determine the frequency and distribution of four types of lesions (erythema, erosion, atrophy, and blister) for each oral site and to calculate the interobserver reliability for each type of lesion in each site...
November 2013: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/23726142/oral-mucoceles-a-clinical-histopathological-and-immunohistochemical-study
#15
Jamile Gomes Conceição, Clarissa Araújo Gurgel, Eduardo Antônio Gonçalves Ramos, Flávia Caló De Aquino Xavier, Caroline Brandi Schlaepfer-Sales, Maria Cristina Teixeira Cangussu, Patrícia Ramos Cury, Luciana Maria Pedreira Ramalho, Jean Nunes Dos Santos
The aim of study was to evaluate the clinicopathological features of oral mucoceles and the immunohistochemical expression of cellular and extracellular matrix components in these lesions. One hundred cases of oral mucoceles were examined for clinicopathological features. The expression of mast cell tryptase, CD68, MMP-1 (matrix metalloproteinase-1), MMP-9 (matrix metalloproteinase-9) and CD34 was investigated immunohistochemically in 32 cases. The lesions arose as nodules or blisters of variable color. The mean age was 23...
January 2014: Acta Histochemica
https://www.readbyqxmd.com/read/23616346/recurrent-oral-blood-blisters
#16
Crispian Scully
No abstract text is available yet for this article.
May 2013: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/23108156/p63-control-of-desmosome-gene-expression-and-adhesion-is-compromised-in-aec-syndrome
#17
Giustina Ferone, Maria Rosaria Mollo, Helen A Thomason, Dario Antonini, Huiqing Zhou, Raffaele Ambrosio, Laura De Rosa, Domenico Salvatore, Spiro Getsios, Hans van Bokhoven, Jill Dixon, Caterina Missero
Ankyloblepharon, ectodermal defects, cleft lip/palate (AEC) syndrome is a rare autosomal dominant disorder caused by mutations in the p63 gene, essential for embryonic development of stratified epithelia. The most severe cutaneous manifestation of this disorder is the long-lasting skin fragility associated with severe skin erosions after birth. Using a knock-in mouse model for AEC syndrome, we found that skin fragility was associated with microscopic blistering between the basal and suprabasal compartments of the epidermis and reduced desmosomal contacts...
February 1, 2013: Human Molecular Genetics
https://www.readbyqxmd.com/read/21911958/hand-foot-and-mouth-disease
#18
Radhika Muppa, Prameela Bhupatiraju, Mahesh Duddu, Arthi Dandempally
Hand, foot and mouth disease (HFMD) is an acute viral illness with a distinct clinical presentation of oral and characteristic distal extremity lesions. Knowledge of this is important for the dentists as the oral lesions are the first clinical signs and sometimes may be the only sign because the condition occasionally may regress even before the lesions appear on the extremities. This case describes a 5-year-old boy in whom low-grade fever of 38.7°C and oral lesions were the initial manifestations. Proper diagnosis was established later based on the typical location of the initial intraoral ulcers on the soft palate followed by cutaneous lesions on the hands and feet with vesicle formation surrounded by an erythematous halo...
April 2011: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/21605803/the-genetics-of-pemphigus
#19
REVIEW
Animesh A Sinha
Pemphigus vulgaris (PV) is an autoimmune blistering disorder with a complex etiology involving an interplay of genetic as well as environmental factors, most of which remain unknown. Despite the identification of several human leukocyte antigen (HLA) alleles as risk factors for disease, no other non-HLA genes have clearly been implicated in disease susceptibility. Newer candidate gene and whole-genome approaches are needed to illuminate the full palate of genetic risk elements in PV. Based on this information, genetic-based tools can be expected to provide a scientific rationale for future clinical decision-making by physicians and facilitate an era of personalized medicine...
July 2011: Dermatologic Clinics
https://www.readbyqxmd.com/read/21409967/bullous-hemorrhagic-darier-disease
#20
María Pilar Sánchez-Salas, Francisco Javier García Latasa de Aranibar, Rosa Oncíns Torres, Paula Gambó Grasa
A 48-year-old man presented with a 4-month history of papular hyperkeratotic diffuse lesions on his trunk, arms, and neck that were highly pruritic (Figure 1). He also had "V"-shaped nicks in the nails, mucous white papules on his palate, and diffuse desquamation on the scalp. Abnormal laboratory values included elevated levels of uric acid and triglycerides. Serum electrolytes, blood sugar, and renal and liver function test results were within normal range. X-ray film and abdominal ultrasonography findings were also normal...
January 2011: Skinmed
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