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https://www.readbyqxmd.com/read/29329760/sodium-glucose-transporter-as-a-novel-therapeutic-target-in-disease
#1
REVIEW
Yui Yamazaki, Shinichi Harada, Shogo Tokuyama
Glucose is the primary energy fuel of life. A glucose transporter, the sodium-glucose transporter (SGLT), is receiving attention as a novel therapeutic target in disease. This review summarizes the physiological role of SGLT in cerebral ischemia, cancer, cardiac disease, and intestinal ischemia, which has encouraged analysis of SGLT function. In cerebral ischemia and cardiomyopathy, SGLT-1 is involved in worsening of the injury. In addition, SGLT-1 promotes the development of cancer. On the other hand, SGLT-1 has a protective effect against cardiac and intestinal ischemia...
January 9, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29329123/golf-injuries-epidemiology-pathophysiology-and-treatment
#2
Ioannis C Zouzias, Jeff Hendra, Jason Stodelle, Orr Limpisvasti
Increasing numbers of people are playing golf. Golf is a unique sport in that the ability to participate at a high level is not limited by age. In addition, participants tend to play more rather than less as they grow older. Injuries can occur at any point during the golf swing, from takeaway through follow-through. Upper extremity injuries can affect the hands, elbow, and shoulder and are usually a result of the golf swing at impact. Injuries are also common in the lower back as well as the lower extremities...
January 11, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29326958/performance-and-return-to-sport-after-thumb-ulnar-collateral-ligament-repair-in-major-league-baseball-players
#3
Robert A Jack, Kyle R Sochacki, Bryce Gagliano, David M Lintner, Joshua D Harris, Patrick C McCulloch
Background: Acute ruptures of the ulnar collateral ligament (UCL) of the thumb are common injuries in sports. Surgical repair has yielded excellent results and high return-to-sport (RTS) rates in elite athletes. Purpose: To determine (1) the RTS rate in Major League Baseball (MLB) players following thumb UCL repair, (2) postoperative career length and games played per season, (3) pre- and postoperative performance, (4) postoperative performance compared with matched control players, and (5) whether dominant and nondominant hand injuries respond differently...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29326906/a-comparison-of-ground-reaction-force-components-according-to-the-foothold-heights-in-16-t-truck-during-downward-step
#4
Seung-Hyun Hyun, Che-Cheong Ryew
The aim of this study is to compare and analyze the components of ground reaction force (GRF) relative to the foothold heights during downward step of 16-t truck. Adult males (n= 10) jumped downward from each 1st, 2nd, 3rd foothold step and driver's seat orderly using hand rail. Sampling rate of force components of 3 axis (medial-lateral [ML] GRF, anterior-posterior [AP] GRF, peak vertical force [PVF]), variables (COPx, COPy, COP area) of center of pressure (COP), loading rate, and stability index (ML, AP, vertical, and dynamic postural stability index [DPSI]) processed from GRF system was cut off at 1,000 Hz...
December 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29324427/lemons-in-the-arizona-sunshine-the-effects-of-furocoumarins-leading-to-phytophotodermatitis-and-burn-like-injuries
#5
Marc R Matthews, Joel C VanderVelde, Daniel M Caruso, Kevin N Foster
INTRODUCTION: Phytophototoxic dermatitis is a strong phototoxic reaction to ultraviolet A (UV-A) radiation exposure after cutaneous contact with citrus fruit containing furocoumarins, leading to skin injury. At the Arizona Burn Center (Phoenix, AZ), the majority of these injuries are managed in the outpatient setting. CASE REPORT: The authors present a pediatric admission for burn-like injuries following prolonged cutaneous exposure to lemons while playing in the Arizona sunshine...
December 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29322889/outcomes-of-open-reduction-and-internal-fixation-in-displaced-intra-articular-scapular-fractures-a-case-series
#6
M Zahid, E H Rashid, H Inam, A J Zubairi, N Baloch, P M Hashmi
Scapular fractures are rare injuries and usually occur due to high energy trauma. Displaced Intra articular fractures usually require operative treatment and yields better outcomes as compared to conservative management. To assess the functional and radiological outcomes of displaced intra-articular scapular fractures managed with open reduction and internal fixation. 12 patients were retrospectively reviewed and included in the study. Post-operative functional outcomes were assessed using mean quick DASH (Disability of arm, hand and shoulder) score while radiological outcomes were analyzed as percentage of implant cut-through, mal-union, non-union or infection...
March 2017: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29321396/-molecular-and-cellular-mechanisms-underlying-the-sterile-inflammation-after-ischemic-stroke
#7
Takashi Shichita
Inflammation is an essential step for the pathology of ischemic stroke, and is also an important therapeutic target for developing novel therapeutic methods which have a wide therapeutic time window. Since there is no pathogen in the brain, the inflammation will be triggered by some endogenous molecules which are called as danger associated molecular patterns (DAMPs). So far two important DAMPs, high mobility group box 1 (HMGB1) and peroxiredoxin (PRX), have been recently identified in the ischemic brain. HMGB1 exaggerates the disruption of blood brain barrier; on the other hand, PRX activates mononuclear phagocytes and induces the inflammatory cytokine production through the activation of Toll-like receptor 2 (TLR2) and TLR4...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29320962/replantation-and-revascularization-of-amputated-upper-limb-appendages-outcome-and-predicting-the-factors-influencing-the-success-rates-of-these-procedures-in-a-tertiary-hospital-an-8-year-retrospective-cross-sectional-study
#8
Tunku Kamarul, Azura Mansor, Noorzurani Robson, Salim Hh Albusaidi, Abdulrazzaq M Suhaeb, Ely Z Samsudin
PURPOSE: Worldwide advances in microsurgery have made salvaging of amputated hand via replantation and revascularization common procedures. The present study examines the outcome of these procedures in a tertiary hospital in Malaysia. METHODS: Patients with hand amputation who underwent replantation or revascularization from 2005 to 2012 were identified and reviewed for patient characteristics, amputation characteristics and survival rates. Successfully treated patients were interviewed to assess the functional outcome using Quick Disability of the Arm, Shoulder and Hand (Quick-DASH) questionnaire and Michigan Hand Outcome Questionnaire (MHQ)...
January 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29319352/dual-antegrade-intramedullary-headless-screw-fixation-for-treatment-of-unstable-proximal-phalanx-fractures
#9
Michael P Gaspar, Shiv D Gandhi, Randall W Culp, Patrick M Kane
BACKGROUND: Although intramedullary headless screw (IMHS) fixation is a promising minimally invasive surgical treatment option for unstable proximal phalanx fractures, a single IMHS may provide inadequate fixation for certain fracture patterns. The purpose of this study was to evaluate the short-term clinical outcomes in a pilot series of patients with proximal phalanx fractures treated with dual antegrade IMHS fixation. METHODS: We performed a retrospective chart review of proximal phalanx fractures treated with dual antegrade IMHS fixation with a minimum 1 year of follow-up...
January 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29318178/outcomes-after-dermal-allograft-reconstruction-of-chronic-or-subacute-pectoralis-major-tendon-ruptures
#10
Julie A Neumann, Christopher M Klein, Carola F van Eck, Hithem Rahmi, John M Itamura
Background: Avoiding delay in the surgical management of pectoralis major (PM) ruptures optimizes outcomes. However, this is not always possible, and when a tear becomes chronic or when a subacute tear has poor tissue quality, a graft can facilitate reconstruction. Purpose: The primary aim was to evaluate the clinical outcomes of PM reconstruction with dermal allograft augmentation for chronic tears or for subacute tears with poor tissue quality. A second aim was to determine patient and surgical factors affecting outcome...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29317574/-role-of-immune-related-gtpase-m1-in-cortical-neurons-autophagy-of-mice-with-sepsis-induced-brain-injury
#11
Qun Huang, Bin Chen, Yafei Li, Xihong Li
To investigate the role of immune-related GTPase M1 (IRGM1) in cortical neurons autophagy in mice with sepsis induced brain injury (SIBI).
 Methods: Sixty wild-type C57BL/6 mice and sixty IRGM1 gene knockout C57BL/6 mice were randomly divided into 4 groups: a sham-operated wild-type (SWT) group, a cecal ligation and puncture (CLP) model wild-type (MWT) group, a sham-operated knockout (SKO) group, and a CLP model knockout (MKO) group. Models of mice with sepsis were established by CLP. Six hours of after CLP, the neurobehavioral scores for mice were recorded...
December 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29317055/scapholunate-interosseous-ligament-dysfunction-as-a-source-of-elbow-pain-syndromes-possible-mechanisms-and-implications-for-hand-surgeons-and-therapists
#12
Cigdem Ayhan, Seval Tanrıkulu, Gursel Leblebicioglu
Elbow pain syndromes are common upper extremity musculoskeletal disorders, and they are usually associated with repetitive occupational exposure. Ligaments are often one of the sources of musculoskeletal disorders because of their mechanical and neurological properties. The wrist ligaments are some of the ligaments most vulnerable to occupational exposure. Since most occupational tasks require wrist extension for handling tools and loading, the scapholunate interosseous ligament (SLIL) bears greater strain during loading, which results in creep deformation and hysteresis...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29316583/-foreign-body-ingestion-a-rare-cause-of-abdominal-pain
#13
Philipp Kasper, Fabian Kütting, Hans Anton Schlößer, Stefan Paul Mönig, Tobias Goeser, Natalie Jaspers
HISTORY AND FINDINGS UPON ADMISSION:  A 50-year-old man presented at the emergency unit with abdominal pain in the right lower quadrant and dysuria. He described an increase in pain during micturition. EXAMINATIONS:  After multiple examinations (CT-scan, MR-scan, ileocolonoscopy) were performed to no avail, a toothpick was detected in the terminal ileum during an ultrasound scan of the small intestine. Prompted elevation of intra-abdominal pressure led to migration of the radiolucent sharp foreign body into the wall of the urinary bladder, inducing pain...
January 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29313890/violence-in-paradise-cranial-trauma-in-the-prehispanic-population-of-gran-canaria-canary-islands
#14
Teresa Delgado-Darias, Verónica Alberto-Barroso, Javier Velasco-Vázquez
OBJECTIVES: This paper addresses the prevalence and pattern of physical violence in the prehispanic society of Gran Canaria and discusses its link with the social structure and insular context in which that people lived. MATERIALS AND METHODS: 347 prehispanic crania from Guayadeque Ravine (575-1415 AD) have been examined in order to determine the frequency, types, location, and timing of trauma. RESULTS: Craniofacial injuries are present in 27...
January 4, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29312999/covertly-active-and-progressing-neurochemical-abnormalities-in-suppressed-hiv-infection
#15
Lucette A Cysique, Lauriane Jugé, Thomas Gates, Michael Tobia, Kirsten Moffat, Bruce J Brew, Caroline Rae
Objective: To assess whether HIV-related brain injury is progressive in persons with suppressed HIV infection. Methods: Seventy-three HIV+ virally suppressed men and 35 HIV- men, screened for psychiatric and alcohol/drug use disorders, underwent neuropsychological evaluation and proton magnetic resonance spectroscopy (1H-MRS) at baseline and after and 23 ± 5 months. 1H-MRS included brain regions known to be vulnerable to HIV and aging: frontal white matter (FWM), posterior cingulate cortex (PCC), and caudate area (CA)...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29310404/extracorporeal-membrane-oxygenation-combined-with-continuous-renal-replacement-therapy-in-cutaneous-burn-and-inhalation-injury-caused-by-hydrofluoric-acid-and-nitric-acid
#16
Qinhua Pu, Jinxian Qian, Weiyi Tao, Aixiang Yang, Jian Wu, Yaodong Wang
RATIONALE: Hydrofluoric acid (HF) is a highly corrosive agent and can cause corrosive burns. HF can penetrate deeply into tissues through intact skin and the lipid barrier, leading to painful liquefactive necrosis, and inducing hypocalcemia and hypomagnesemia. In this study, we hypothesize that continuous renal replacement therapy (CRRT) may be beneficial in addressing hemodynamic instability in cases of HF poisoning. PATIENT CONCERNS: A 25-year-old man fell into an electroplating pool containing 10% HF and 50% nitric acid...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29307126/incidence-and-characteristics-of-hospitalizations-after-dog-s-bite-injuries-in-sicily-italy-between-2012%C3%A2-2015
#17
Daniela Alberghina, Antonino Virga, Sergio Pio Buffa, Michele Panzera
There have been several studies focusing on dogs bite injuries and their epidemiology. To our knowledge, the incidence and characteristics of hospitalization after a dogs bite injury have not been examined quantitatively in Italy. The aim of this study was to identify the incidence and characteristics of dogs bite hospitalizations throughout Sicily (Italy) between 2012-2015. Data for statistical analysis were acquired through the Epidemiological Observatory and Health Department of Sicilian Region (Italy). One hundred and forty records with E-code 906...
December 29, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/29306577/diaphyseal-forearm-fractures-20-years-after-surgical-treatment-is-there-still-an-indication-for-percutaneous-fixation
#18
M R Fernández-Marín, M Hidalgo-Pérez, G Arias-Rodríguez, A García-Mendoza, E Prada-Chamorro, G Domecq-Fernández de Bobadilla
OBJECTIVE: This is a retrospective study of 98 diaphyseal forearm fractures in adults, treated by a percutaneous technique with intramedullar Kirchner wires. MATERIALS AND METHOD: We reviewed 64 patients with 98 forearm fractures with a radiographic follow-up, assessing the presence of pseudarthrosis or delayed bone union and evaluating functional outcomes with the Anderson and the Disability of the Arm, Shoulder and Hand scale. RESULTS: Clinical and radiological bone union was achieved in an average of 12 weeks...
January 3, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29303923/flexor-tendon-injuries
#19
Christopher S Klifto, John T Capo, Anthony Sapienza, S Steven Yang, Nader Paksima
Flexor tendon injuries of the hand are uncommon, and they are among the most challenging orthopaedic injuries to manage. Proper management is essential to ensure optimal outcomes. Consistent, successful management of flexor tendon injuries relies on understanding the anatomy, characteristics and repair of tendons in the different zones, potential complications, rehabilitation protocols, recent advances in treatment, and future directions, including tissue engineering and biologic modification of the repair site...
January 15, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29302138/are-the-domains-considered-by-icf-comprehensive-enough-to-conceptualize-participation-in-the-patient-with-hand-injuries
#20
Maryam Farzad, Fereydoun Layeghi, Seyyed Ali Hosseini, Khanke Hamidreza, Ali Asgari
Background  Although participation is a core concept in multiple models of disability, there is no consensus on its definition. Objective  The aim of this study was to extract participation domains based on review of theories, available outcome measures, and interviews with experts and the person with hand injuries to compare with the ICF domains of participation. Methods  A qualitative approach using a deductive content analysis was employed to extend definitions of participation from theories. Later on, inductive qualitative method using semistructured interview with five experts in different fields and 30 patients with different hand injuries was used...
December 2017: Journal of Hand and Microsurgery
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