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https://www.readbyqxmd.com/read/29168173/the-role-of-melatonin-on-chemotherapy-induced-reproductive-toxicity
#1
REVIEW
Hamed Haghi-Aminjan, Mohammad Hossein Asghari, Bagher Farhood, Mahban Rahimifard, Nasser Hashemi Goradel, Mohammad Abdollahi
OBJECTIVES: Reproductive malfunctions after chemotherapy still are a reason of reducing fertility and need specialized intensive care. The aim of this review was to investigate the effect of melatonin on the reproductive system under threatening with chemotherapeutic drugs. METHODS: To find the role of melatonin in the reproductive system during chemotherapy, a full systematic literature search was carried out based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines in the electronic databases up to 17 April 2017 using search terms in the titles and abstracts...
November 23, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29166930/a-prospective-cohort-study-identifying-risk-factors-for-shoulder-injuries-in-adolescent-elite-handball-players-the-karolinska-handball-study-khast-study-protocol
#2
Martin Asker, Markus Waldén, Henrik Källberg, Lena W Holm, Eva Skillgate
BACKGROUND: Handball is a physical contact sport that includes frequent overhead throwing, and this combination leads to a high rate of shoulder injuries. Several factors have been associated with shoulder injuries in overhead athletes, but strong scientific evidence is lacking for most suggested risk factors. We therefore designed the Karolinska Handball Study (KHAST) with the aim to identify risk factors for shoulder injuries in adolescent male and female elite handball players studying at handball-profiled secondary schools in Sweden...
November 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29164431/response-of-the-gabaergic-system-to-axotomy-of-the-rat-facial-nerve
#3
Reika Kikuchi, Makoto Hamanoue, Maasa Koshimoto, Shinichi Kohsaka, Kazuyuki Nakajima
The responses of inhibitory neurons/synapses to motoneuron injury in the cranial nervous system remain to be elucidated. In this study, we analyzed GABAA receptor (GABAAR) and GABAergic neurons at the protein level in the transected rat facial nucleus. Immunoblotting revealed that the GABAARα1 protein levels in the axotomized facial nucleus decreased significantly 5-14 days post-insult, and these levels remained low for 5 weeks. Immunohistochemical analysis indicated that the GABAARα1-expressing cells were motoneurons...
November 21, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29164407/neurological-complications-of-hiv-infection
#4
REVIEW
Shelli Farhadian, Payal Patel, Serena Spudich
PURPOSE OF REVIEW: HIV-associated neurocognitive disorders (HAND) are common in patients with HIV disease, even during suppressive combination antiretroviral therapy (cART). This review article addresses the pathogenesis of HAND, focusing on important findings from the last 5 years. RECENT FINDINGS: While HIV-associated dementia is now rare in settings with cART availability, mild forms of HAND are increasing in prevalence. Biomarkers of cellular injury, such as neurofilament light chain and neopterin, can detect early stages of neuroinflammation associated with HIV infection and are increased even in asymptomatic individuals with chronic HIV infection...
November 21, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29164394/combination-of-nad-and-nadph-offers-greater-neuroprotection-in-ischemic-stroke-models-by-relieving-metabolic-stress
#5
Qiao Huang, Meiling Sun, Mei Li, Dingmei Zhang, Feng Han, Jun Chao Wu, Kohji Fukunaga, Zhong Chen, Zheng-Hong Qin
Both reduced nicotinamide adenine dinucleotide phosphate (NADPH) and β-nicotinamide adenine dinucleotide hydrate (NAD(+)) have been reported to have potent neuroprotective effects against ischemic neuronal injury. Both NADPH and NAD(+) are essential cofactors for anti-oxidation and cellular energy metabolism. We investigated if combined NADPH and NAD(+) could offer better neuroprotective effects on cellular and animal models of ischemic stroke. In vitro studies with primary cultured neurons demonstrated that NAD(+) was effective in protecting neurons against oxygen-glucose deprivation/reoxygenation (OGD/R) injury when given during the early time period of reoxygenation...
November 21, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29164029/a-clinical-practice-guideline-for-the-management-of-patients-with-acute-spinal-cord-injury-recommendations-on-the-type-and-timing-of-rehabilitation
#6
Michael G Fehlings, Lindsay A Tetreault, Bizhan Aarabi, Paul Anderson, Paul M Arnold, Darrel S Brodke, Kazuhiro Chiba, Joseph R Dettori, Julio C Furlan, James S Harrop, Gregory Hawryluk, Langston T Holly, Susan Howley, Tara Jeji, Sukhvinder Kalsi-Ryan, Mark Kotter, Shekar Kurpad, Brian K Kwon, Ralph J Marino, Allan R Martin, Eric Massicotte, Geno Merli, James W Middleton, Hiroaki Nakashima, Narihito Nagoshi, Katherine Palmieri, Anoushka Singh, Andrea C Skelly, Eve C Tsai, Alexander Vaccaro, Jefferson R Wilson, Albert Yee, Anthony S Burns
Introduction: The objective of this study is to develop guidelines that outline the appropriate type and timing of rehabilitation in patients with acute spinal cord injury (SCI). Methods: A systematic review of the literature was conducted to address key questions related to rehabilitation in patients with acute SCI. A multidisciplinary guideline development group used this information, and their clinical expertise, to develop recommendations for the type and timing of rehabilitation...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29164023/type-and-timing-of-rehabilitation-following-acute-and-subacute-spinal-cord-injury-a-systematic-review
#7
REVIEW
Anthony S Burns, Ralph J Marino, Sukhvinder Kalsi-Ryan, James W Middleton, Lindsay A Tetreault, Joseph R Dettori, Kathryn E Mihalovich, Michael G Fehlings
Objectives: The objective of this study was to conduct a systematic review of the literature to address the following clinical questions: In adult patients with acute and subacute complete or incomplete traumatic SCI, (1) does the time interval between injury and commencing rehabilitation affect outcome?; (2) what is the comparative effectiveness of different rehabilitation strategies, including different intensities and durations of treatment?; (3) are there patient or injury characteristics that affect the efficacy of rehabilitation?; and (4) what is the cost-effectiveness of various rehabilitation strategies? Methods: A systematic search was conducted for literature published through March 31, 2015 that evaluated rehabilitation strategies in adults with acute or subacute traumatic SCI at any level...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29163211/oxidative-stress-in-the-local-and-systemic-events-of-apical-periodontitis
#8
REVIEW
Patricia Hernández-Ríos, Pirkko J Pussinen, Rolando Vernal, Marcela Hernández
Oxidative stress is involved in the pathogenesis of a variety of inflammatory disorders. Apical periodontitis (AP) usually results in the formation of an osteolytic apical lesion (AL) caused by the immune response to endodontic infection. Reactive oxygen species (ROS) produced by phagocytic cells in response to bacterial challenge represent an important host defense mechanism, but disturbed redox balance results in tissue injury. This mini review focuses on the role of oxidative stress in the local and associated systemic events in chronic apical periodontitis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162658/hand-and-wrist-injuries-among-us-high-school-athletes-2005-06-2015-16
#9
Bernadette K Johnson, Lina Brou, Sarah K Fields, Alexandria N Erkenbeck, R Dawn Comstock
BACKGROUND: The risk of hand/wrist injuries is present across various sports. Little is known about the epidemiology of such injuries. The objective of this study was to calculate the rates of hand/wrist injuries and investigate injury patterns among high school athletes. METHODS: Athlete exposure (AE) and hand/wrist injury data were collected during 11 academic years, 2005/06 through 2015/16, from a large sample of US high schools as part of the National High School Sports-Related Injury Surveillance Study...
November 21, 2017: Pediatrics
https://www.readbyqxmd.com/read/29162296/early-outcomes-of-vein-grafting-for-reconstruction-of-brachial-arterial-injuries-in-children
#10
Kristin Alves, Hillard Spencer, Carol E Barnewolt, Peter M Waters, Donald S Bae
PURPOSE: We postulated that, with microsurgical technique, vascular reconstruction with interpositional vein grafts in the pediatric population is safe and results in sustained vascular patency and excellent midterm outcomes. METHODS: Twenty children with brachial artery injuries were treated with interpositional vein grafting at a tertiary pediatric hospital from 1995 to 2013. Medical records were evaluated for demographic, clinical, and radiographic data. Ten patients were available for longer-term follow-up...
November 18, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29161666/genetic-variants-and-acute-kidney-injury-a-review-of-the-literature
#11
REVIEW
Daniel B Larach, Milo C Engoren, Ellen M Schmidt, Michael Heung
PURPOSE: Limited data exists on potential genetic contributors to acute kidney injury. This review examines current knowledge of AKI genomics. MATERIALS AND METHODS: 32 studies were selected from PubMed and GWAS Catalog queries for original data studies of human AKI genetics. Hand search of references identified 3 additional manuscripts. RESULTS: 33 of 35 studies were hypothesis-driven investigations of candidate polymorphisms that either did not consistently replicate statistically significant findings, or obtained significant results only in few small-scale studies...
November 13, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29161264/proprioceptive-assessment-in-clinical-settings-evaluation-of-joint-position-sense-in-upper-limb-post-stroke-using-a-robotic-manipulator
#12
Sara Contu, Asif Hussain, Simone Kager, Aamani Budhota, Vishwanath A Deshmukh, Christopher W K Kuah, Lester H L Yam, Liming Xiang, Karen S G Chua, Lorenzo Masia, Domenico Campolo
Proprioception is a critical component for motor functions and directly affects motor learning after neurological injuries. Conventional methods for its assessment are generally ordinal in nature and hence lack sensitivity. Robotic devices designed to promote sensorimotor learning can potentially provide quantitative precise, accurate, and reliable assessments of sensory impairments. In this paper, we investigate the clinical applicability and validity of using a planar 2 degrees of freedom robot to quantitatively assess proprioceptive deficits in post-stroke participants...
2017: PloS One
https://www.readbyqxmd.com/read/29160240/remapping-cortical-modulation-for-electrocorticographic-brain-computer-interfaces-a-somatotopy-based-approach-in-individuals-with-upper-limb-paralysis
#13
Alan D Degenhart, Shivayogi V Hiremath, Ying Yang, Stephen T Foldes, Jennifer L Collinger, Michael L Boninger, Elizabeth C Tyler-Kabara, Wei Wang
OBJECTIVE: Brain-computer interface (BCI) technology aims to provide individuals with paralysis a means to restore function. Electrocorticography (ECoG) uses disc electrodes placed on either the surface of the dura or the cortex to record field potential activity. ECoG has been proposed as a viable neural recording modality for BCI systems, potentially providing stable, long-term recordings of cortical activity with high spatial and temporal resolution. Previously we have demonstrated that a subject with spinal cord injury (SCI) could control an ECoG-based BCI system with up to three degrees of freedom [Wang et al...
November 21, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29160014/loss-of-tenascin-x-gene-function-impairs-injury-induced-stromal-angiogenesis-in-mouse-corneas
#14
Takayoshi Sumioka, Hiroki Iwanishi, Yuka Okada, Yuka Nidegawa, Masayasu Miyajima, Ken-Ichi Matsumoto, Shizuya Saika
To determine the contribution by tenascin X (Tnx) gene expression to corneal stromal angiogenesis, the effects were determined of its loss on this response in TNX knockout (KO) mice. In parallel, the effects of such a loss were evaluated on vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGFβ1) gene and protein expression in fibroblasts and macrophages in cell culture. Histological, immunohistochemical and quantitative RT-PCR changes determined if Tnx gene ablation on angiogenic gene expression, inflammatory cell infiltration and neovascularization induced by central corneal stromal cauterization...
November 21, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29159432/comparison-of-the-neuroprotective-effects-of-brimonidine-tartrate-and-melatonin-on-retinal-ganglion-cells
#15
Deniz Marangoz, Elif Guzel, Signem Eyuboglu, Asli Gumusel, Ismail Seckin, Ferda Ciftci, Bayram Yilmaz, Ilgaz Yalvac
PURPOSE: We aimed to compare the neuroprotective effects of brimonidine tartrate (BRT) and melatonin (MEL) on retinal ganglion cells (RGCs) in a rat glaucoma model. METHODS: Thirty-six adult Wistar albino rats were allocated into six groups: control (C), glaucoma (G), BRT, MEL, G + BRT and G + MEL. After establishing the glaucoma model, intraocular pressure (IOP) of all animals measured at day 4 and day 30 was compared statistically with day 0 and day 4, respectively...
November 20, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29157082/radioprotective-efficacy-of-ginkgo-biloba-and-angelica-archangelica-extract-against-technetium-99m-sestamibi-induced-oxidative-stress-and-lens-injury-in-rats
#16
Mahmoud H Khedr, Medhat W Shafaa, Amany Abdel-Ghaffar, Ahmed Saleh
PURPOSE: Technetium-99m is a radioactive tracer that emits gamma rays. Its half-life time is 6 hours. Similar to other ionizing radiations, the main mechanism of radiation-induced effects is initiated through the production of Reactive Oxygen Species (ROS). The present study was designed to determine the possible protective effects of Ginkgo-Biloba and Angelica-Archangelica against oxidative organ damage that was induced by (99m)Tc-sestamibi. MATERIALS AND METHODS: The experiments were performed on thirty-six Wistar-rats which were subdivided into control groups and groups exposed to (99m)Tc-sestamibi...
November 20, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29156788/modulation-of-hif-1%C3%AE-and-stat3-signaling-contributes-to-anti-angiogenic-effect-of-yc-1-in-mice-with-liver-fibrosis
#17
Tzung-Yan Lee, Yann-Lii Leu, Chorng-Kai Wen
Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The aim of the study was to evaluate the mechanisms of HIF-1α inhibitor, YC-1, during bile duct ligation (BDL)-induced liver fibrosis in mice. Liver fibrosis was induced in mice, and YC-1 was then given intraperitoneally (50 mg/kg) once daily following 5 days. Liver injuries mice that were treated with YC-1 showed improved inflammatory response and diminished angiogenesis and hepatic fibrosis. YC-1 treatment inhibited liver neutrophil infiltration, while a decreased in TNF-α signaling as well as macrophage aggregation...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156655/the-role-of-glyoxalase-i-glo-i-advanced-glycation-endproducts-ages-and-their-receptor-rage-in-chronic-liver-disease-and-hepatocellular-carcinoma-hcc
#18
REVIEW
Marcus Hollenbach
Glyoxalase-I (Glo-I) and glyoxalase-II (Glo-II) comprise the glyoxalase system and are responsible for the detoxification of methylglyoxal (MGO). MGO is formed non-enzymatically as a by-product, mainly in glycolysis, and leads to the formation of advanced glycation endproducts (AGEs). AGEs bind to their receptor, RAGE, and activate intracellular transcription factors, resulting in the production of pro-inflammatory cytokines, oxidative stress, and inflammation. This review will focus on the implication of the Glo-I/AGE/RAGE system in liver injury and hepatocellular carcinoma (HCC)...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156496/sensation-mechanoreceptor-and-nerve-fiber-function-after-nerve-regeneration
#19
Christian Krarup, Birgitta Rosén, Michel Boeckstyns, Allan Ibsen Sørensen, Göran Lundborg, Mihai Moldovan, Simon J Archibald
OBJECTIVE: Sensation is essential for recovery after peripheral nerve injury. However, the relationship between sensory modalities and function of regenerated fibers is uncertain. We have investigated the relationships between touch threshold, tactile gnosis and mechanoreceptor and sensory fiber function after nerve regeneration. METHODS: Twenty-one median or ulnar nerve lesions were repaired by a collagen nerve conduit or direct suture. Quantitative sensory hand function and sensory conduction studies by near-nerve technique including tactile stimulation of mechanoreceptors were followed for 2 years, and results were compared to non-injured hands...
November 20, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29156445/autologous-tenocyte-implantation-into-shoulder-tendon-pathology-in-an-elite-swimmer
#20
Laura M Schwab, Peter Blanch, Mark Young
INTRODUCTION: The use of novel bioengineer treatment techniques such as Autologous Tenocyte Implantation (ATI) have shown promising improvements in both pain ratings and functional outcomes in elbow, gluteal and shoulder tendon pathology. This case will review the injury timeline of ATI intervention in an elite male swimmer with subscapularis tendon pathology and investigate whether ATI has a concomitant healing effect associated with improved functional outcomes. METHODS: A palmaris longus tendon biopsy was performed and cells were expanded by in-vitro culture...
October 13, 2017: Physical Therapy in Sport
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