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https://www.readbyqxmd.com/read/29035775/avoiding-the-pocket-a-case-report-of-coiling-of-distal-shunt-catheter-into-subcutaneous-pocket
#1
Richard Justin Garling, Sandeep Sood, Carolyn Anne Harris
INTRODUCTION: Hydrocephalus is one of the most common disorders of neurosurgery and ventricular shunting, the primary surgical intervention, malfunctions in 85% of patients by 10 years. PRESENTATION OF CASE: Here we present a case of a 12-year-old girl with history of a vagal nerve stimulator (VNS) and ventricular shunt, most recently revised from ventriculoatrial (VA) to ventriculoperitoneal (VP) shunt at an outside hospital. The patient presented with a new left chest bulge, nausea, emesis, and seizures...
October 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29033896/the-influence-of-a-kdt501-a-novel-isohumulone-on-adipocyte-function-in-humans
#2
Brian S Finlin, Beibei Zhu, Bernard P Kok, Cristina Godio, Philip M Westgate, Neile Grayson, Robert Sims, Jeffrey S Bland, Enrique Saez, Philip A Kern
OBJECTIVE: In a phase II clinical trial in nine obese, insulin-resistant humans, we observed that treatment with KDT501, a novel isohumulone drug, increased total and high-molecular weight (HMW) adiponectin in plasma. The objective was to determine whether KDT501 increased adiponectin secretion from subcutaneous white adipose tissue (SC WAT) and the underlying mechanism(s). METHODS: Nine obese participants with either prediabetes or with normal glucose tolerance plus three features of metabolic syndrome were part of the study...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29030173/a-novel-miniature-wireless-neurostimulator-in-the-management-of-chronic-craniofacial-pain-preliminary-results-from-a-prospective-pilot-study
#3
Richard L Weiner, Carlos Montes Garcia, Niek Vanquathem
OBJECTIVE: To report a novel wireless neuromodulation system for treatment of refractory craniofacial pain. BACKGROUND: Previous studies utilizing peripheral nerve stimulation (PNS) of the occipital and trigeminal nerves reported positive outcomes for alleviating neuropathic pain localized to the craniofacial and occipital areas. However several technological limitations and cosmetic concerns inhibited a more widespread acceptance and use of neuromodulation. Also, a relatively high incidence of adverse events like electrode erosions, dislocation, wire fracture and/or infection at the surgical site mandates a change in our approach to neuromodulation technology and implant techniques in the craniofacial region...
October 10, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29021893/the-efficacy-of-oral-and-subcutaneous-antigen-specific-immunotherapy-in-murine-cow-s-milk-and-peanut-allergy-models
#4
Marlotte M Vonk, Laura Wagenaar, Raymond H H Pieters, Leon M J Knippels, Linette E M Willemsen, Joost J Smit, Betty C A M van Esch, Johan Garssen
BACKGROUND: Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow's milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety. AIM: Compare oral immunotherapy (OIT) and subcutaneous immunotherapy (SCIT) in murine models for CMA and PNA and determine the dose of allergen needed to effectively modify parameters of allergy. METHODS: Female C3H/HeOuJ mice were sensitized intragastrically (i...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29016994/neuromodulation-in-postherpetic-neuralgia-case-reports-and-review-of-the-literature
#5
Svetlana Kurklinsky, Scott C Palmer, Mack J Arroliga, Salim M Ghazi
Objective: Postherpetic neuralgia (PHN) is common in the United States. Current treatment options for PHN are fairly limited. Spinal cord stimulation (SCS) and peripheral nerve stimulation (PNS) are considered mostly experimental and still rarely performed in patients with PHN. Design: Two case reports and a review of the literature. Setting: Tertiary academic medical center. Methods: 1) Pubmed, Ovid, and EBMR databases were searched for all reports that had the following key words: postherpetic neuralgia, spinal cord stimulation, and peripheral nerve stimulation...
July 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29016879/agonist-ox40-immunotherapy-improves-survival-in-glioma-bearing-mice-and-is-complementary-with-vaccination-with-irradiated-gm-csf-expressing-tumor-cells
#6
Nusrat Jahan, Hammad Talat, William T Curry
Background: Glioma immunotherapy is an active area of clinical investigation. Glioma-associated immunosuppression remains an obstacle to efficacious immunotherapy, and combination approaches are likely necessary for durable success. OX40 is a member of the tumor necrosis factor receptor superfamily that is upregulated on activated lymphocytes, ligation of which results in enhanced activity and may be active against cancer. We sought to confirm the efficacy of agonist anti-OX40 immunotherapy against glioma and hypothesized that it is complementary with irradiated whole tumor cell vaccination...
July 7, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28989540/immunotheranostic-polymersomes-modularly-assembled-from-tetrablock-and-diblock-copolymers-with-oxidation-responsive-fluorescence
#7
Fanfan Du, Yu-Gang Liu, Evan Alexander Scott
INTRODUCTION: Intracellular delivery is a key step for many applications in medicine and for investigations into cellular function. This is particularly true for immunotherapy, which often requires controlled delivery of antigen and adjuvants to the cytoplasm of immune cells. Due to the complex responses generated by the stimulation of diverse immune cell populations, it is critical to monitor which cells are targeted during treatment. To address this issue, we have engineered an immunotheranostic polymersome delivery system that fluorescently marks immune cells following intracellular delivery...
October 2017: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/28988765/results-of-a-phase-1-2-study-in-metastatic-renal-cell-carcinoma-patients-treated-with-a-patient-specific-adjuvant-multi-peptide-vaccine-after-resection-of-metastases
#8
Steffen Rausch, Cécile Gouttefangeas, Jörg Hennenlotter, Karoline Laske, Kerstin Walter, Susan Feyerabend, Premachandran Anoop Chandran, Stephan Kruck, Harpreet Singh-Jasuja, Annemarie Frick, Nils Kröger, Stefan Stevanović, Arnulf Stenzl, Hans-Georg Rammensee, Jens Bedke
Treatment of metastatic renal cell carcinoma comprises metastasectomy±systemic medical treatment. Specific immunotherapy after metastasectomy could be a complementary option. In this phase 1/2 study, safety and tolerability of an adjuvant multi-peptide vaccine (UroRCC) after metastasectomy was evaluated together with immune response and efficacy, compared with a contemporary cohort of patients (n=44) treated with metastasectomy only. Nineteen metastatic renal cell carcinoma patients received UroRCC via intradermal or subcutaneous application randomized to immunoadjuvants (granulocyte-macrophage colony-stimulating factor or Montanide)...
October 4, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28986166/sildenafil-induces-browning-of-subcutaneous-white-adipose-tissue-in-overweight-adults
#9
Shuguang Li, Yixiang Li, Lin Xiang, Jing Dong, Min Liu, Guangda Xiang
OBJECTIVE: To investigate that short-term treatment of sildenafil can induce browning of subcutaneous white adipose tissue (sWAT) in human adults. DESIGN: A randomized, double-blinded, placebo-controlled, parallel group trial. METHODS: Sixteen eligibility overweight male subjects were recruited, comparing 100 mg/day sildenafil versus an identical placebo therapy for 7 days. sWAT samples were collected from subjects before and after 7-day sildenafil or placebo intervention...
October 3, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28980909/tocilizumab-in-two-children-with-pansclerotic-morphoea-a-hopeful-therapy-for-refractory-cases
#10
Giorgia Martini, Simona Campus, Raffeiner Bernd, Gianluca Boscarol, Alessandra Meneghel, Francesco Zulian
Pansclerotic morphoea (PM) is a subtype of juvenile localised scleroderma characterised by severe course with generalised full-thickness skin involvement and possible growth and functional impairment. PM treatment comprises a combination of immunosuppressive agents such as corticosteroids, methotrexate, mycophenolate mofetil, PUVA and antithymocyte globulin and biological agents used in off-label. A possible role of IL-6 in the regulation of firoblast differentiation and stimulation of collagen synthesis has been suggested and in patients with systemic sclerosis (SSc) the treatment with tocilizumab (TCZ) was associated to improvement of skin thickness and joint motion...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28979120/engineered-outer-membrane-vesicle-is-potent-to-elicit-hpv16e7-specific-cellular-immunity-in-a-mouse-model-of-tc-1-graft-tumor
#11
Shijie Wang, Weiwei Huang, Kui Li, Yufeng Yao, Xu Yang, Hongmei Bai, Wenjia Sun, Cunbao Liu, Yanbing Ma
PURPOSE: Currently, therapeutic tumor vaccines under development generally lack significant effects in human clinical trials. Exploring a powerful antigen delivery system is a potential approach to improve vaccine efficacy. We sought to explore engineered bacterial outer membrane vesicles (OMVs) as a new vaccine carrier for efficiently delivering tumor antigens and provoking robust antitumor immune responses. MATERIALS AND METHODS: First, the tumoral antigen human papillomavirus type 16 early protein E7 (HPV16E7) was presented on Escherichia coli-derived OMVs by genetic engineering methods, acquiring the recombinant OMV vaccine...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28972200/fibrinogen-modified-sodium-alginate-as-a-scaffold-material-for-skin-tissue-engineering
#12
Elena V Solovieva, Alexander Yu Fedotov, Vasily E Mamonov, Vladimir S Komlev, Andrey A Panteleyev
In search for a new pro-angiogenic scaffold material suitable for skin bioengineering and grafting therapy, we have fabricated a number of composite sodium alginate (AG) - fibrinogen (FG) sponge scaffolds using the freeze-drying approach. Thrombin was added to drive FG/fibrin conversion, while ε-aminocapronic acid (εAc) was used as antifibrinolytic component. The slow rates of scaffold biodegradation were achieved by using Ca2+ and Mg2+ cations as cross-linking agents. The novel thrombin-modified AG-FG scaffolds with highly interconnected porous structure were evaluated using scanning electron microscopy, tensile testing and pycnometric analysis...
October 3, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28965266/periostin-silencing-suppresses-the-aggressive-phenotype-of-thyroid-carcinoma-cells-by-suppressing-the-akt-thyroid-stimulating-hormone-receptor-axis
#13
Min Wang, Chunyi Gui, Shenglong Qiu, Jingdong Tang, Zhihai Peng
Clinical evidence indicates that high periostin expression correlates with aggressive phenotype in thyroid carcinoma. However, the biological roles of periostin in thyroid carcinoma development and progression are still unclear. In this study, we explored the effects of periostin silencing on thyroid carcinoma cell growth, invasion, and tumorigenesis. We also studied the impact of periostin on the activation of phosphoinositide 3-kinase (PI3-K)/Akt signaling, which is involved in the pathogenesis of thyroid carcinoma...
September 30, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28962498/thoracic-surgery-in-patients-with-an-implanted-neurostimulator-device
#14
Kristina Meyring, Adrian Zehnder, Ralph A Schmid, Gregor J Kocher
Movement disorders such as Parkinson's disease are increasingly treated with deep brain stimulators. Being implanted in a subcutaneous pocket in the chest region, thoracic surgical procedures can interfere with such devices, as they are sensible to external electromagnetic forces. Monopolar electrocautery can lead to dysfunction of the device or damage of the brain tissue caused by heat. We report a series of 3 patients with deep brain stimulators who underwent thoracic surgery. By turning off the deep brain stimulators before surgery and avoiding the use of monopolar cautery, electromagnetic interactions were avoided in all patients...
October 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28957008/immunity-elicited-by-a-turkey-herpesvirus-vectored-newcastle-disease-vaccine-in-turkey-against-challenge-with-a-recent-genotype-iv-newcastle-disease-virus-field-strain
#15
Abderrazak El Khantour, Sami Darkaoui, Tímea Tatár-Kis, Tamás Mató, Amal Essalah-Bennani, Christophe Cazaban, Vilmos Palya
Newcastle disease (ND) is still a major poultry disease worldwide. Vaccination remains the principal method of controlling ND in endemic countries. Various vaccination strategies, including the use of recently developed recombinant vaccines, have been used to control it. Recombinant vaccines that use the herpesvirus of turkey (HVT) as a vector to express one of the key antigens of Newcastle disease virus (NDV) have been developed to overcome some of the drawbacks related to the use of conventional vaccines...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28956695/tumor-cell-invasion-induced-by-radiation-in-balb-c-mouse-is-prevented-by-the-cox-2-inhibitor-ns-398
#16
Rosalie Lemay, Martin Lepage, Luc Tremblay, Hélène Therriault, Gabriel Charest, Benoit Paquette
Radiation stimulates the expression of inflammatory mediators known to increase cancer cell invasion. Therefore, it is important to determine whether anti-inflammatory drugs can prevent this adverse effect of radiation. Since cyclooxygenase-2 (COX-2) is a central player in the inflammatory response, we performed studies to determine whether the COX-2 inhibitor NS-398 can reduce the radiation enhancement of cancer cell invasion. Thighs of Balb/c mice treated with NS-398 were irradiated with either daily fractions of 7...
September 28, 2017: Radiation Research
https://www.readbyqxmd.com/read/28956378/-design-and-immunogenicity-evaluation-for-the-bacteria-like-particle-vaccine-against-swine-type-o-foot-and-mouth-disease-virus
#17
Liting Hou, Jin Chen, Xuwen Qiao, Xiaoming Yu, Jibo Hou, Qisheng Zheng, Jinnian Li
Based on gram positive enhancer matrix displaying technology, we designed and evaluated a bacteria-like particle vaccine against swine type O Foot-and-mouth disease virus. Three optimized genes of type O Foot-and-mouth disease virus strain Mya98 were cloned into recombinant prokaryotic expression vector pQZ-PA and renamed as pQZ-BT1B-PA, pQZ-BT2B-PA and pQZ-B (T1BT2) 4B-PA, fused with an anchor protein (PA) binding to Gram-positive enhancer matrix (GEM) particles specifically. The protein expression was identified with SDS-PAGE and Western blotting, and then purified with GEM particles...
February 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28954463/comparison-of-5-different-rat-models-to-establish-a-standard-animal-model-for-research-into-interstitial-cystitis
#18
Phil Hyun Song, So Young Chun, Jae-Wook Chung, Yeon Yong Kim, Hyo Jung Lee, Jun Nyung Lee, Yun-Sok Ha, Eun Sang Yoo, Tae Gyun Kwon, Jeongshik Kim, Dae Hwan Kim, Bum Soo Kim
PURPOSE: We evaluated 5 different rat models using different agents in order to establish a standard animal model for interstitial cystitis (IC) in terms of the functional and pathologic characteristics of the bladder. METHODS: Five IC models were generated in 8-week-old female Sprague-Dawley rats via transurethral instillation of 0.1M hydrogen chloride (HCl) or 3% acetic acid (AA), intraperitoneal injection of cyclophosphamide (CYP) or lipopolysaccharide (LPS), or subcutaneous injection of uroplakin II (UPK2)...
September 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28954201/rhesus-theta-%C3%AE-defensin-1-attenuates-endotoxin-induced-acute-lung-injury-by-inhibiting-proinflammatory-cytokines-and-neutrophil-recruitment
#19
Jordanna G Jayne, Timothy J Bensman, Justin B Schaal, A Young J Park, Elza Kimura, Dat Tran, Michael E Selsted, Paul M Beringer
Acute lung injury (ALI) is a clinical syndrome characterized by acute respiratory failure and is associated with substantial morbidity and mortality. Rhesus theta defensin-1 (RTD-1) is an antimicrobial peptide with immunomodulatory activity. As airway inflammation and neutrophil recruitment and activation are hallmarks of ALI, we evaluated the therapeutic efficacy of RTD-1 in pre-clinical models of the disease. We investigated the effect of RTD-1 on neutrophil chemotaxis and macrophage-driven pulmonary inflammation with human peripheral neutrophils and LPS-stimulated murine alveolar macrophage (MH-S) cells...
September 27, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28948894/minimally-invasive-technique-for-intrathecal-administration-of-morphine-in-rats-practicality-and-antinociceptive-properties
#20
Aurelie Anic Thomas, Johann Detilleux, Charlotte Friederike Sandersen, Paul Andrew Flecknell
The intrathecal (IT) route of administration represents a means to reduce the dose of morphine administered for analgesia, potentially minimizing interactions between opioid effects and experimental outcomes. Perceived technical difficulty, and previously described invasive methods, may limit its use. This report describes a minimally invasive technique for IT administration of morphine by direct transcutaneous lumbosacral puncture in rats; and assesses antinociceptive properties of morphine in anaesthetized rats...
October 2017: Laboratory Animals
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