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peripheral nerve field stimulation

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https://www.readbyqxmd.com/read/29666407/an-implantable-peripheral-nerve-recording-and-stimulation-system-for-experiments-on-freely-moving-animal-subjects
#1
Byunghun Lee, Mukhesh K Koripalli, Yaoyao Jia, Joshua Acosta, M S E Sendi, Yoonsu Choi, Maysam Ghovanloo
A new study with rat sciatic nerve model for peripheral nerve interfacing is presented using a fully-implanted inductively-powered recording and stimulation system in a wirelessly-powered standard homecage that allows animal subjects move freely within the homecage. The Wireless Implantable Neural Recording and Stimulation (WINeRS) system offers 32-channel peripheral nerve recording and 4-channel current-controlled stimulation capabilities in a 3 × 1.5 × 0.5 cm3 package. A bi-directional data link is established by on-off keying pulse-position modulation (OOK-PPM) in near field for narrow-band downlink and 433 MHz OOK for wideband uplink...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29664415/model-based-optimal-multipolar-stimulation-without-a-priori-knowledge-of-nerve-structure-application-to-vagus-nerve-stimulation
#2
Melissa Dali, Olivier Rossel, David Andreu, Laure Laporte, Alfredo Hernandez, Jeremy Laforet, Eloi Marijon, Albert Hagège, Maureen Clerc, Christine Henry, David Guiraud
OBJECTIVE: Multipolar cuff electrode can selectively stimulate areas of peripheral nerves and therefore enable to control independent functions. However, the branching and fascicularization are known for a limited set of nerves and the specific organization remains subject-dependent. This paper presents a general modeling and optimization methods in the context of multipolar stimulation using a cuff electrode without a priori knowledge of the nerve structure. Vagus nerve stimulation experiments based on the optimization results were then investigated...
April 17, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29651458/differential-expression-of-voltage-gated-sodium-channels-in-afferent-neurons-renders-selective-neural-block-by-ionic-direct-current
#3
Fei Yang, Michael Anderson, Shaoqiu He, Kimberly Stephens, Yu Zheng, Zhiyong Chen, Srinivasa N Raja, Felix Aplin, Yun Guan, Gene Fridman
The assertion that large-diameter nerve fibers have low thresholds and small-diameter fibers have high thresholds in response to electrical stimulation has been held in a nearly axiomatic regard in the field of neuromodulation and neuroprosthetics. In contrast to the short pulses used to evoke action potentials, long-duration ionic direct current has been shown to block neural activity. We propose that the main determinant of the neural sensitivity to direct current block is not the size of the axon but the types of voltage-gated sodium channels prevalent in its neural membrane...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29608807/long-term-effect-of-peripheral-nerve-field-stimulation-as-add-on-therapy-to-spinal-cord-stimulation-to-treat-low-back-pain-in-failed-back-surgery-syndrome-patients-a-12-month-follow-up-of-a-randomized-controlled-study
#4
Eric-Jan J A A van Gorp, Onno Teernstra, Hans J Aukes, Tanja Hamm-Faber, Katja Bürger, Jan Willem Kallewaard, Geert Spincemaille, Johannes W L C Schapendonk, Leon Vonhögen, Ewald Bronkhorst, Kris C P Vissers
OBJECTIVE: Different approaches in neuromodulation have been used to treat chronic low back pain in failed back surgery syndrome (FBSS) patients. We previously randomized 52 FBSS patients to be treated with spinal cord stimulation (SCS) and additional peripheral nerve field stimulation (PNFS) or SCS alone. At three months, we found a significant reduction of back pain in the PNFS-SCS group compared to the SCS group. In the subsequent open phase part of the study, all patients received optimal SCS and PNFS simultaneously...
April 2, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29588969/neurostimulation-as-a-promising-epilepsy-therapy
#5
REVIEW
Yicong Lin, Yuping Wang
The revolution in theory, swift technological developments, and invention of new devices have driven tremendous progress in neurostimulation as a third-line treatment for epilepsy. Over the past decades, neurostimulation took its place in the field of epilepsy as an advanced treatment technique and opened up a new world. Numerous animal studies have proven the physical efficacy of stimulation of the brain and peripheral nerves. Based on this optimistic fundamental research, new advanced techniques are being explored in clinical practice...
December 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29566284/clinical-effect-of-c2-peripheral-nerve-field-stimulation-using-electroacupuncture-for-primary-headache
#6
Sumire Ishiyama, Yasushi Shibata, Satoshi Ayuzawa, Akira Matsushita, Akira Matsumura
OBJECTIVE: We applied C2 peripheral nerve field stimulation using electroacupuncture (EA-C2-PNfS) for primary headache, and investigated its clinical effectiveness. MATERIALS AND METHODS: Fifty-four primary headache patients (10 men, 44 women) with a mean age of 48.6 ± 15.0 years underwent EA-C2-PNfS for three months. We used questionnaires to assess outcomes; pain intensity (11-point numerical rating scale [NRS]), quality of daily life (Headache Impact Test [HIT-6]), depression (Self-Rating Depression Scale [SDS])...
March 22, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29524643/sequential-variation-in-brain-functional-magnetic-resonance-imaging-after-peripheral-nerve-injury-a-rat-study
#7
Okihiro Onishi, Kazuya Ikoma, Ryo Oda, Tetsuro Yamazaki, Hiroyoshi Fujiwara, Shunji Yamada, Masaki Tanaka, Toshikazu Kubo
Although treatment protocols are available, patients experience both acute neuropathic pain and chronic neuropathic pain, hyperalgesia, and allodynia after peripheral nerve injury. The purpose of this study was to identify the brain regions activated after peripheral nerve injury using functional magnetic resonance imaging (fMRI) sequentially and assess the relevance of the imaging results using histological findings. To model peripheral nerve injury in male Sprague-Dawley rats, the right sciatic nerve was crushed using an aneurysm clip, under general anesthesia...
March 7, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29500628/-nummular-headache-subcutaneous-peripheral-nerve-field-stimulation-as-an-individual-therapeutic-attempt
#8
F Bünger, D Feierabend, P Storch, R Kalff, R Reichart
BACKGROUND: Subcutaneous peripheral nerve field stimulation (sPNFS) is an established procedure for the treatment of chronic localized neuropathic pain of peripheral origin. The treatment of nummular headache primarily focuses on conservative methods with limited prospects of success. The role of sPNFS in the treatment of nummular headache has not been investigated as yet. QUESTION: Is the sPNFS an option in the management of nummular headache? MATERIALS AND METHODS: In addition to a summary of established methods in the treatment of nummular headache, sPNFS as a possible form of therapy is discussed...
March 2, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29454657/monitoring-brain-neuronal-activity-with-manipulation-of-cardiac-events-in-a-freely-moving-rat
#9
Yu Shikano, Yuji Ikegaya, Takuya Sasaki
Behavioral and cognitive studies have demonstrated that brain functions are affected by the activity states of the peripheral organs, such as the cardiac and respiratory systems. However, detailed neurophysiological mechanisms underlying the body-brain interactions remain unknown. In this study, we developed a method for manipulating activity levels of the heart using direct cardiac stimulation and vagus nerve stimulation that can be combined with recording cerebral local field potentials using a microdrive system, electrocardiograms, electromyograms, in a freely moving rat...
February 15, 2018: Neuroscience Research
https://www.readbyqxmd.com/read/29425907/visceral-pain-novel-approaches-for-optogenetic-control-of-spinal-afferents
#10
Nick J Spencer, Tim J Hibberd, Malin Lagerström, Yoichiro Otsuka, Nigel Kelly
Painful stimuli arising within visceral organs are detected by peripheral nerve endings of spinal afferents, whose cell bodies are located in dorsal root ganglia (DRG). Recent technical advances have made it possible to reliably expose and inject single DRG with neuronal tracers or viruses in vivo. This has facilitated, for the first time, unequivocal identification of different types of spinal afferent endings in visceral organs. These technical advances paved the way for a very exciting series of in vivo experiments where individual DRG are injected to facilitate opsin expression (e...
February 6, 2018: Brain Research
https://www.readbyqxmd.com/read/29333355/bilateral-peripheral-nerve-field-stimulation-for-intractable-coccygeal-pain-a-case-study-using-dual-lead-intercommunication
#11
Michelle Granville, Patrick T Brennan, Robert E Jacobson
Coccygeal pain is a difficult chronic pain problem with mixed response to various treatments. This is a report of a case of coccygeal pain that after failing various conservative and interventional procedures over five years was evaluated with a temporary peripheral sacral fascial lead followed by implantation of bilateral sacral paramedian leads for peripheral nerve field stimulation (PNFS). This resulted in marked pain control and resumption of full activity. The visual analog scale (VAS) pain score improved from eight pre-implant to one after implant and has remained at that level in follow-up...
November 9, 2017: Curēus
https://www.readbyqxmd.com/read/29303111/chronic-implantation-of-cuff-electrodes-on-the-pelvic-nerve-in-rats-is-well-tolerated-and-does-not-compromise-afferent-or-efferent-fibre-functionality
#12
J J Crook, C B J Brouillard, P P Irazoqui, T A Lovick
OBJECTIVE: Neuromodulation of autonomic nerve activity to regulate physiological processes is an emerging field. Vagal stimulation has received most attention whereas the potential of modulate visceral function by targeting autonomic nerves within the abdominal cavity remains under-exploited. Surgery to locate intra-abdominal targets is inherently more stressful than for peripheral nerves. Electrode leads risk becoming entrapped by intestines and loss of functionality in the nerve-target organ connection could result from electrode migration or twisting...
January 5, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29285055/restoration-of-orbicularis-oculi-muscle-function-in-rabbits-with-peripheral-facial-paralysis-via-an-implantable-artificial-facial-nerve-system
#13
Yajing Sun, Cheng Jin, Keyong Li, Qunfeng Zhang, Liang Geng, Xundao Liu, Yi Zhang
The purpose of the present study was to restore orbicularis oculi muscle function using the implantable artificial facial nerve system (IAFNS). The in vivo part of the IAFNS was implanted into 12 rabbits that were facially paralyzed on the right side of the face to restore the function of the orbicularis oculi muscle, which was indicated by closure of the paralyzed eye when the contralateral side was closed. Wireless communication links were established between the in vivo part (the processing chip and microelectrode) and the external part (System Controller program) of the system, which were used to set the working parameters and indicate the working state of the processing chip and microelectrode implanted in the body...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29275012/progress-in-pharmacological-research-of-chemokine-like-factor-1-cklf1
#14
REVIEW
Dan-Dan Liu, Xiu-Yun Song, Peng-Fei Yang, Qi-Di Ai, Ying-Ying Wang, Xiao-Ye Feng, Xin He, Nai-Hong Chen
Currently, the research of chemokines has penetrated into many fields of life science. A new kind of chemokines, chemokine like factor 1 (CKLF1), which is cloned through suppression subtractive hybridisation (SSH) technology is expressed widely in human body, especially in the lung and peripheral blood leukocytes. CKLF1 has a broad spectrum of chemotaxic activity for many cells, such as lymphocytes, macrophages, bone marrow cells, nerve cells and so on. In addition, CKLF1 also stimulates the regeneration of skeletal muscle cells in vivo...
February 2018: Cytokine
https://www.readbyqxmd.com/read/29248528/feasibility-safety-and-efficacy-of-subcutaneous-peripheral-nerve-field-stimulation-for-the-treatment-of-refractory-low-back-pain-a-two-year-single-center-study
#15
Basem Ishak, Benito Campos, Heike Brunn, Andreas W Unterberg, Rezvan Ahmadi
Chronic low back pain (CLBP) is challenging to treat. Minimal invasive neurostimulation therapies, such as subcutaneous peripheral nerve field stimulation (SPNS), improve pain relief and quality of life. The goal of the present study was to assess the usefulness, safety, and efficacy of SPNS in patients with CLBP. Twenty-six consecutive patients with CLBP were prospectively included in the study. For trial neurostimulation, two electrodes were implanted vertically at a depth of 1 cm into the subcutaneous tissue, ≤10 cm from the region of maximum pain...
December 15, 2017: Neuroscience
https://www.readbyqxmd.com/read/29201608/toward-bioelectronic-medicine-neuromodulation-of-small-peripheral-nerves-using-flexible-neural-clip
#16
Sanghoon Lee, Wendy Yen Xian Peh, Jiahui Wang, Fengyuan Yang, John S Ho, Nitish V Thakor, Shih-Cheng Yen, Chengkuo Lee
Neural modulation technology and the capability to affect organ function have spawned the new field of bioelectronic medicine. Therapeutic interventions depend on wireless bioelectronic neural interfaces that can conformally and easily attach to small (few hundred micrometers) nerves located deep in the body without neural damage. Besides size, factors like flexibility and compliance to attach and adapt to visceral nerves associated moving organs are of paramount importance and have not been previously addressed...
November 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29197566/local-subcutaneous-injection-of-chlorogenic-acid-inhibits-the-nociceptive-trigeminal-spinal-nucleus-caudalis-neurons-in-rats
#17
Kaede Kakita, Hirona Tsubouchi, Mayu Adachi, Shiori Takehana, Yoshihito Shimazu, Mamoru Takeda
Acute administration of chlorogenic acid (CGA) in vitro was recently shown to modulate potassium channel conductance and acid-sensing ion channels (ASICs) in the primary sensory neurons; however, in vivo peripheral effects of CGA on the nociceptive mechanical stimulation of trigeminal neuronal activity remains to be determined. The present study investigated whether local administration of CGA in vivo attenuates mechanical stimulation-induced excitability of trigeminal spinal nucleus caudalis neuronal (SpVc) activity in rats...
November 29, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29191577/electrical-stimulation-of-the-insular-cortex-as-a-novel-target-for-the-relief-of-refractory-pain-an-experimental-approach-in-rodents
#18
Luiz Fabio Dimov, Elaine Flamia Toniolo, Heloísa Alonso-Matielo, Daniel Ciampi de Andrade, Luis Garcia-Larrea, Gerson Ballester, Manoel Jacobsen Teixeira, Camila Squarzoni Dale
Cortical electrical stimulation (CES) has shown to be an effective therapeutic alternative for neuropathic pain refractory to pharmacological treatment. The primary motor cortex(M1) was the main cortical target used in the vast majority of both invasive and non-invasive studies. Despite positive results M1-based approaches still fail to relieve pain in a significant proportion of individuals. It has been advocated that the direct stimulation of cortical areas directly implicated in the central integration of pain could increase the efficacy of analgesic brain stimulation...
November 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29163122/selectivity-and-longevity-of-peripheral-nerve-and-machine-interfaces-a-review
#19
REVIEW
Usman Ghafoor, Sohee Kim, Keum-Shik Hong
For those individuals with upper-extremity amputation, a daily normal living activity is no longer possible or it requires additional effort and time. With the aim of restoring their sensory and motor functions, theoretical and technological investigations have been carried out in the field of neuroprosthetic systems. For transmission of sensory feedback, several interfacing modalities including indirect (non-invasive), direct-to-peripheral-nerve (invasive), and cortical stimulation have been applied. Peripheral nerve interfaces demonstrate an edge over the cortical interfaces due to the sensitivity in attaining cortical brain signals...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/29161621/human-subthalamic-oscillatory-dynamics-following-somatosensory-stimulation
#20
Saskia Elben, Carlos Trenado, Jan Vesper, Alfons Schnitzler, Lars Wojtecki
OBJECTIVE: Electrical median nerve somatosensory stimulation leads to a distinct modulation of cortical oscillations. Initial high frequency and gamma augmentation, as well as modulation of beta and alpha oscillations have been reported. We aimed at investigating the involvement of the subthalamic nucleus in somatosensory processing by means of local field potential recordings, since recordings during passive movements and peripheral somatosensory stimulation have suggested a prominent role...
January 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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