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https://www.readbyqxmd.com/read/28938451/antibody-mediated-targeting-of-the-fgfr1c-isoform-increases-glucose-uptake-in-white-and-brown-adipose-tissue-in-male-mice
#1
Jo E Lewis, Ricardo J Samms, Scott Cooper, Jeni C Luckett, Alan C Perkins, James D Dunbar, Dennis P Smith, Paul J Emmerson, Andrew C Adams, Francis J P Ebling, Kostas Tsintzas
The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population. Antibody-mediated targeting of fibroblast growth factor receptor 1c isoform (FGFR1c) has been shown to ameliorate hyperglycaemia and protect from diet- and genetically-induced obesity in rodents and non-human primates. However, it is currently unknown which tissue(s) contribute to this glucose lowering effect...
August 16, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938434/fgf21-is-an-insulin-dependent-postprandial-hormone-in-adult-humans
#2
Ricardo J Samms, Jo E Lewis, Luke Norton, Francis B Stephens, Christopher J Gaffney, Tony Butterfield, Dennis Smith, Christine Cheng, James W Perfield, Andrew C Adams, Francis J P Ebling, Kostas Tsintzas
Context: Fibroblast growth factor 21 (FGF21) secretion has been shown to respond directly to carbohydrate consumption, with glucose, fructose and sucrose all reported to increase plasma levels of FGF21 in rodents and humans. However, carbohydrate consumption also results in secretion of insulin. Objective: The aim of this study was to examine the combined and independent effects of hyperglycemia and hyperinsulinemia on total and bioactive FGF21 in the postprandial period in humans, and determine whether this effect is attenuated in conditions of altered insulin secretion and action...
August 4, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938409/letter-to-the-editor-type-b-insulin-resistance-masquerading-as-ovarian-hyperthecosis
#3
Ricardo Azziz
No abstract text is available yet for this article.
August 14, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938405/short-term-high-fat-diet-increases-leptin-activation-of-cart-neurons-and-advances-puberty-in-female-mice
#4
Jade Cabestre Venancio, Lisandra Oliveira Margatho, Rodrigo C Rorato, Roberta Ribeiro Costa Rosales, Lucas Kniess Debarba, Ricardo Coletti, Jose Antunes-Rodrigues, Carol F Elias, Lucila Leico K Elias
Leptin is a permissive factor for puberty initiation, participating as a metabolic cue in the activation of the kisspeptin (Kiss1)-gonadotropin-releasing hormone neuronal circuitry however, it has no direct effect on Kiss1 neurons. Leptin acts on hypothalamic CART neurons, participating in the regulation of energy homeostasis. We investigated the influence of a short-term high-fat diet (HFD) on the effect of leptin on puberty timing. Kiss1-hrGFP female mice received a HFD or regular diet (RD) after weaning at postnatal day 21 (PN21) and were studied at PN28 and PN32...
September 4, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938320/giant-peripheral-temporomandibular-osteoma-with-immediate-reconstruction-of-mandible
#5
Cláiton Heitz, Ricardo Augusto Conci, Flávio Henrique Silveira Tomazi, Guilherme Pivatto Louzada, Michel Martins Guarenti, Guilherme Genehr Fritscher
Osteoma is a benign osteogenic tumor, which is characterized the slow-growing proliferation of compact or cancellous bone. The etiology of the lesion is not well established. Among the hypotheses, the following are related: a traumatic factor, infectious processes, or true neoplasm due to the origin of cartilaginous cells. It can present at any age, usually in young adult individuals, with equal prevalence in both sexes. The clinical characteristics of the peripheral osteoma are represented by slow asymptomatic growth, which leads to swelling and, thus, facial asymmetry...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28937995/enzootic-mosquito-vector-species-at-equine-encephalitis-transmission-foci-in-the-rep%C3%A3%C2%BAblica-de-panam%C3%A3
#6
Rolando Torres, Rafael Samudio, Jean-Paul Carrera, Josue Young, Ricardo Márquez, Lisbeth Hurtado, Scott Weaver, Luis Fernando Chaves, Robert Tesh, Lorenzo Cáceres
The identification of mosquito vector species present at arboviral enzootic transmission foci is important to understand transmission eco-epidemiology and to propose and implement prevention and control strategies that reduce vector-borne equine encephalitis transmission. The goal of this study was to identify mosquito species potentially involved in the transmission of enzootic equine encephalitis, in relation to their abundance and diversity at three endemic regions in the República de Panamá. We sampled adult mosquitoes during the dry and rainy season of Panamá...
2017: PloS One
https://www.readbyqxmd.com/read/28937502/type-iii-interferons-in-systemic-lupus-erythematosus-association-between-interferon-%C3%AE-3-disease-activity-and-anti-ro-ssa-antibodies
#7
Luis M Amezcua-Guerra, Ricardo Márquez-Velasco, Adriana K Chávez-Rueda, Diana Castillo-Martínez, Felipe Massó, Araceli Páez, Juan Colín-Fuentes, Rafael Bojalil
OBJECTIVE: The aim of this study was to assess associations between serum type III (λ) interferons (IFN-λ) and disease activity in systemic lupus erythematosus (SLE). METHODS: Serum levels of IFN-λ1, IFN-λ2, and IFN-λ3 were measured in 93 SLE patients and 67 healthy individuals. The associations with overall disease activity, organ-specific damage, and SLE-related antibodies were assessed. RESULTS: Median IFN-λ1 levels were 0 pg/mL (range, 0-510 pg/mL) and 0 pg/mL (0-171 pg/mL; P = 0...
September 21, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937472/type-iii-interferons-in-systemic-lupus-erythematosus-association-between-interferon-%C3%AE-3-disease-activity-and-anti-ro-ssa-antibodies
#8
Luis M Amezcua-Guerra, Ricardo Márquez-Velasco, Adriana K Chávez-Rueda, Diana Castillo-Martínez, Felipe Massó, Araceli Páez, Juan Colín-Fuentes, Rafael Bojalil
OBJECTIVE: The aim of this study was to assess associations between serum type III (λ) interferons (IFN-λ) and disease activity in systemic lupus erythematosus (SLE). METHODS: Serum levels of IFN-λ1, IFN-λ2, and IFN-λ3 were measured in 93 SLE patients and 67 healthy individuals. The associations with overall disease activity, organ-specific damage, and SLE-related antibodies were assessed. RESULTS: Median IFN-λ1 levels were 0 pg/mL (range, 0-510 pg/mL) and 0 pg/mL (0-171 pg/mL; P = 0...
October 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937445/cervical-cancer-posttreatment-follow-up-critical-analysis
#9
Ingrid Hillesheim, Gabriel Augusto Limone, Lucia Klimann, Heleusa Monego, Marcia Appel, Alessandra de Souza, Ricardo Dos Reis
OBJECTIVE: The aim of this study was to evaluate the role of follow-up tests and examinations in diagnosing symptomatic and asymptomatic relapses after treatment for cervical cancer. METHODS: Data were collected from medical records for all patients diagnosed as having cervical cancer from January 1985 to June 2010. The significance level was P < 0.005. RESULTS: Sixty-four (17.8%) of the 358 patients investigated suffered tumor relapse...
October 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28937173/adsorption-of-molecular-hydrogen-on-coronene-with-a-new-potential-energy-surface
#10
Massimiliano Bartolomei, Ricardo Pérez de Tudela, Kilian Arteaga, Tomás González-Lezana, Marta I Hernández, José Campos-Martínez, Pablo Villarreal, Javier Hernández-Rojas, José Bretón, Fernando Pirani
Benchmark interaction energies between coronene, C24H12, and molecular hydrogen, H2, have been computed by means of high level electronic structure calculations. Binding energies, equilibrium distances and strengths of the long range attraction, evaluated for the basic configurations of the H2-C24H12 complex, indicate that the system is not too affected by the relative orientations of the diatom, suggesting that its behavior can be approximated to that of a pseudoatom. The obtained energy profiles have confirmed the noncovalent nature of the bonding and serve to tune-up the parameters of a new force field based on the atom-bond approach which correctly describes the main features of the H2-coronene interaction...
September 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28936608/the-effect-of-an-increased-pulse-width-on-the-pattern-of-motor-response-unilateral-versus-bilateral-during-the-tsui-test-in-labouring-parturients-a-randomized-crossover-trial
#11
Paul Zakus, Ricardo Bittencourt, Kristi Downey, Ban C H Tsui, Jose C A Carvalho
BACKGROUND AND OBJECTIVES: The typical response to the Tsui test performed via an epidural catheter placed in the lumbar area is the unilateral motor response of the lower limbs. Studies show that longer pulse widths can stimulate peripheral nerves at a lower threshold current from a farther distance. Therefore, we designed a study to test the hypothesis that epidural catheter stimulation with a 1.0-msec pulse width would increase the incidence of bilateral motor response in parturients when compared with stimulation with a 0...
September 21, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28936440/amyand-s-hernia-presenting-as-an-unusual-inguinal-mass-a-case-report
#12
Jennifer To, Paul Hanna, Ricardo Mohammed, Shauna Trinh, Franklyn Vazquez, Jamshed Zuberi, Robert Madlinger
Accounting for approximately 0.4-0.6% of all inguinal hernias, Amyand's hernia is a rare condition in which a vermiform appendix is found in an inguinal hernia sac. It is most commonly found in males and in the pediatric population. Since Claudius Amyand's first reported case in 1736, there have only been a total of 228 documented cases of the Amyand's hernia. Due to its rarity, the pathophysiology and risk factors of the condition are still unclear. Some theorize that it is secondary to a patent processus vaginalis or perhaps the presence of a fibrous band between the hernia sac and testes...
September 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28936283/influence-of-thermal-and-mechanical-fatigue-on-the-shear-bond-strength-of-different-all-ceramic-systems
#13
Hugo-Alberto Vidotti, Jefferson-Ricardo Pereira, Elizeu Insaurralde, Luiz F Plaça, José R Delben, Accácio-Lins do Valle
BACKGROUND: To evaluate the influence of thermal and mechanical fatigue on the shear bond strength of different all-ceramic cores and veneering porcelain interfaces. MATERIAL AND METHODS: All-ceramic systems tested were lithium disilicate and zirconia veneered by layering technique. Sixty specimens (n=20) were subjected to shear bond strength. Ten of them were thermal and mechanical cycled. Fracture analysis was performed with stereomicroscopy and scanning electron microscopy...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28935802/angular-momentum-induced-delays-in-solid-state-photoemission-enhanced-by-intra-atomic-interactions
#14
Fabian Siek, Sergej Neb, Peter Bartz, Matthias Hensen, Christian Strüber, Sebastian Fiechter, Miquel Torrent-Sucarrat, Vyacheslav M Silkin, Eugene E Krasovskii, Nikolay M Kabachnik, Stephan Fritzsche, Ricardo Díez Muiño, Pedro M Echenique, Andrey K Kazansky, Norbert Müller, Walter Pfeiffer, Ulrich Heinzmann
Attosecond time-resolved photoemission spectroscopy reveals that photoemission from solids is not yet fully understood. The relative emission delays between four photoemission channels measured for the van der Waals crystal tungsten diselenide (WSe2) can only be explained by accounting for both propagation and intra-atomic delays. The intra-atomic delay depends on the angular momentum of the initial localized state and is determined by intra-atomic interactions. For the studied case of WSe2, the photoemission events are time ordered with rising initial-state angular momentum...
September 22, 2017: Science
https://www.readbyqxmd.com/read/28935612/use-of-aflp-for-the-study-of-eukaryotic-pathogens-affecting-humans
#15
REVIEW
Carlos M Restrepo, Alejandro Llanes, Ricardo Lleonart
Amplified fragment length polymorphism (AFLP) is a genotyping technique based on PCR amplification of specific restriction fragments from a particular genome. The methodology has been extensively used in plant biology to solve a variety of scientific questions, including taxonomy, molecular epidemiology, systematics, population genetics, among many others. The AFLP share advantages and disadvantages with other types of molecular markers, being particularly useful in organisms with no previous DNA sequence knowledge...
September 18, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28935566/construction-of-protein-functionalized-virus-like-particles-of-parvovirus-b19
#16
Ismael Bustos-Jaimes, Ricardo Arturo Soto-Román, Isabel Alejandra Gutiérrez-Landa, Josefina Valadez-García, Carla Lizbeth Segovia-Trinidad
Decoration of virus-like particles (VLPs) expands the repertory of functions these particles can display. In the last years, VLPs have successfully been used as scaffolds to present different molecules, frequently through the specific reaction of chemical groups on the surface of the particles, or by protein engineering when the presentation of peptides or proteins is the primary goal. VLPs of parvovirus B19 (B19V), have been previously produced in vitro and its stability and ability to assemble into hybrid particles composed of wild-type and chimeric proteins evidenced their potential as research tools...
September 18, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28935440/effects-of-acute-restraint-and-unpredictable-chronic-mild-stress-on-brain-corticotrophin-releasing-factor-mrna-in-the-elevated-t-maze
#17
José S de Andrade, Isabel C Céspedes, Renata O Abrão, Joelcimar M da Silva, Ricardo Ceneviva, Daniel Araki Ribeiro, Jackson C Bittencourt, Milena B Viana
Corticotrophin releasing factor (CRF) modulates stress/anxiety-related responses. Previous studies showed that exposure to acute restraint and unpredictable chronic mild stress (UCMS) facilitates elevated T-maze (ETM) avoidance responses, an anxiogenic-like effect. This study verified the role of CRF in the modulation of ETM avoidance and escape reactions, in unstressed rats and in animals exposed to acute restraint or to UCMS, by quantifying CRF mRNA concentrations in stress/anxiety-related brain regions, through semiquantitative in situ hybridization...
September 18, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28935433/intersectorality-and-social-participation-as-coping-policies-for-health-inequities-worldwide
#18
Regina Celia Fiorati, Ricardo A Arcêncio, Javier Segura Del Pozo, Milagros Ramasco-Gutiérrez, Pilar Serrano-Gallardo
OBJECTIVE: To determine the impact that intersectoral policies and social participation, implemented worldwide, have had on the modification of the social determinants for health and on the reduction of social health inequities. METHOD: A scoping review of the literature published in the period 2005-2015 was performed. The literature search was conducted on PubMed and Scielo databases. Two researchers reviewed each document. Data were analysed according to the intersectoral action and social participation variables and according to the theoretical frameworks of the Social Determinants Model of the Commission on Social Determinants of Health (CSDH) and the theoretical constructs of Social Capital (SC) and Life Course (LC)...
September 18, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28935396/evaluation-of-familial-factors-in-a-mexican-population-based-setting-with-gastroschisis-further-evidence-for-an-underlying-genetic-susceptibility
#19
REVIEW
Victor M Salinas-Torres, Rafael A Salinas-Torres, Ricardo M Cerda-Flores, Laura E Martínez-de-Villarreal
PURPOSE: To evaluate the occurrence of gastroschisis attributable to familial factors in a Mexican population-based setting. METHODS: A descriptive study was performed among gastroschisis cases born from 2010 through 2016 at Tijuana General Hospital (Baja California, Mexico) to generate multigenerational pedigrees. RESULTS: There were 87 gastroschisis cases from 57,217 live births. Six probands (6.9%) had another affected family member. Two half-siblings, a set of monozygotic twins, a mother-and-daughter occurrence, a distant paternal cousin and a distant maternal uncle were identified...
September 1, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28935075/6-month-clinical-and-angiographic-outcomes-of-a-novel-radiopaque-sirolimus-eluting-bioresorbable-vascular-scaffold-the-fantom-ii-study
#20
Alexandre Abizaid, Didier Carrié, Norbert Frey, Matthias Lutz, Joachim Weber-Albers, Darius Dudek, Bernard Chevalier, Shu-Chuan Weng, Ricardo A Costa, Jeffrey Anderson, Gregg W Stone
OBJECTIVES: The purpose of this study was to evaluate the outcomes of the novel Fantom coronary bioresorbable scaffold at 6 months. BACKGROUND: The Fantom sirolimus-eluting bioresorbable scaffold incorporates a unique proprietary iodinated, polycarbonate copolymer of tyrosine analogs that is radiopaque, with thin struts (125 μm) that facilitate device delivery and precise target lesion treatment. METHODS: The 6-month outcomes and performance of the Fantom scaffold were evaluated in 117 patients with single de novo native coronary artery lesions of length ≤20 mm and reference vessel diameter 2...
September 25, 2017: JACC. Cardiovascular Interventions
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