Elizabeth Ann L Enninga, Huy Quang Quach, Jin Sung Jang, Maria Cristina Miranda de Araujo Correia, Yaroslav Fedyshyn, Bohdana Fedyshyn, Maureen Lemens, Dawn Littlefield, Supriya Behl, Elise Sintim-Aboagye, Maria C Mejia Plazas, Maria C Cardenas, Shree Chakraborty, Satoko Yamaoka, Hideki Ebihara, Akhilesh Pandey, Hu Li, Andrew D Badley, Erica L Johnson, Jie Sun, Andrew P Norgan, Regan N Theiler, Rana Chakraborty
BACKGROUND: Hofbauer cells (HBCs) and cytotrophoblasts (CTBs) are major cell populations in placenta. The indirect impact of maternal SARS-CoV-2 disease on these cells that are not directly infected has not been extensively studied. Herein, we profiled gene expression in HBCs and CTBs isolated from placentae of recovered pregnant subjects infected with SARS-CoV-2 during all trimesters of pregnancy, placentae from subjects with active infection, SARS-CoV-2 vaccinated subjects, and those who were unexposed to the virus...
February 7, 2024: PLoS Pathogens