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https://www.readbyqxmd.com/read/27922982/mir-21-is-overexpressed-in-hydatidiform-mole-tissues-and-promotes-proliferation-migration-and-invasion-in-choriocarcinoma-cells
#1
Ya-Xin Wang, Jiu-Ru Zhao, Yue-Ying Xu, Wei-Bin Wu, Hui-Juan Zhang
OBJECTIVE: The aims of this study were to make clear whether miR-21 was dysregulated in hydatidiform mole (HM) tissues and choriocarcinoma (CCA) cells, to elucidate whether aberrant miR-21 expression would affect the function of CCA cells, and to find out whether there was a relationship between miR-21 and AKT, PDCD4, and PTEN in CCA cells. METHODS: Fresh and formalin-fixed, paraffin-embedded trophoblastic tissues (normal first trimester placentas and HMs) were retrieved from the biobank in the International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University...
December 3, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27917469/association-of-dysfunctional-synapse-defective-1-syde1-with-restricted-fetal-growth-syde1-regulates-placental-cell-migration-and-invasion
#2
Hsiao-Fan Lo, Ching-Yen Tsai, Chie-Pein Chen, Liang-Jie Wang, Yun-Shien Lee, Chia-Yu Chen, Chung-Tiang Liang, Mei-Leng Cheong, Hungwen Chen
The transcription factor glial cells missing 1 (GCM1) regulates trophoblast differentiation and function during placentation. Decreased GCM1 expression is associated with preeclampsia, suggesting that abnormal expression of GCM1 target genes may contribute to the pathogenesis of pregnancy complications. Here we identified a novel GCM1 target gene, synapse defective 1 (SYDE1), which encodes a RhoGAP that is highly expressed in human placenta, and demonstrated that SYDE1 promotes cytoskeletal remodelling and cell migration and invasion...
December 5, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27895585/feto-maternal-trafficking-of-exosomes-in-murine-pregnancy-models
#3
Samantha Sheller-Miller, Jun Lei, George Saade, Carlos Salomon, Irina Burd, Ramkumar Menon
Timing and initiation of labor are well-orchestrated by signals communicated between the fetal and maternal compartments; however, how these signals are communicated is not completely understood. Fetal exosomes, intercellular signaling vesicles, may play a key role in the process. The objective of this study was to evaluate exosome trafficking in vivo from fetal to maternal compartments. Pregnant CD-1 mice were intra-amniotically injected on gestational day 16 and 17 with exosomes isolated from primary human amnion epithelial cells fluorescently labeled with the lipophilic dye 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR)...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27878289/oncogenic-function-of-plac1-on-the-proliferation-and-metastasis-in-hepatocellular-carcinoma-cells
#4
Yuan Wu, Xiaocong Lin, Xiaoqing Di, Yonghua Chen, Hanning Zhao, Xin Wang
Placenta-specific protein 1 (Plac1), which is selectively expressed in the placental syncytiotrophoblast in adult normal tissues, plays an essential role in normal placental and embryonic development. Accumulating evidence suggests that enhanced Plac1 expression is closely associated with the progression of human cancer. Whether Plac1 contributes to the pathophysiology of hepatocellular carcinoma (HCC) remains unclear. In the present study, our data revealed that the expression of Plac1 in human HCC tissues was upregulated, which significantly correlated with metastasis of HCC...
November 23, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27871470/the-function-of-mir-519d-in-cell-migration-invasion-and-proliferation-suggests-a-role-in-early-placentation
#5
REVIEW
Lan Xie, Yoel Sadovsky
The processes of proliferation, migration, and invasion of extravillous trophoblasts are critical for placental implantation and early development, and directly influence pregnancy outcome. Dysregulation of these processes has been associated with placental dysfunction, implicated in clinical conditions such as preeclampsia and placental accreta. Among diverse microRNA (miRNA) species that are expressed in placental trophoblasts, members of the chromosome 19 miRNA cluster (C19MC) stand out in their nearly exclusive expression in the placenta...
December 2016: Placenta
https://www.readbyqxmd.com/read/27864359/endothelin-1-down-regulates-matrix-metalloproteinase-14-and-15-expression-in-human-first-trimester-trophoblasts-via-endothelin-receptor-type-b
#6
Alejandro Majali-Martinez, Philipp Velicky, Jürgen Pollheimer, Martin Knöfler, Hong Wa Yung, Graham J Burton, Nassim Ghaffari Tabrizi-Wizsy, Uwe Lang, Ursula Hiden, Gernot Desoye, Martina Dieber-Rotheneder
STUDY QUESTION: Does endothelin-1 (ET-1) regulate matrix metalloproteinase (MMP) 14 and 15 production and invasion of human first trimester trophoblasts? SUMMARY ANSWER: ET-1 in pathophysiological concentrations down-regulates MMP14 and MMP15 expression via endothelin receptor (ETR) type B and decreases trophoblast migration and invasion. WHAT IS KNOWN ALREADY: MMP14 and MMP15 are involved in trophoblast invasion. Impairment of invasion has been linked to pregnancy complications such as pre-eclampsia (PE)...
November 17, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27861702/placental-implantation-and-migration-following-a-previous-caesarean-section-scar
#7
Reihaneh Pirjani, Farahnaz Seifmanesh, Afsaneh Tehranian, Ladan Hosseini, Reza Heidari, Alireza Ghajar, Mahdi Sepidarkish
This prospective cohort study was conducted in Arash Women's Hospital between August 2014 and August 2015 to define the relationship between caesarean section scar and placental implantation and migration. Seven hundred and thirty women with one previous birth (caesarean section or vaginal delivery) and a singleton pregnancy underwent three ultrasound examinations for placental evaluation at 11-14, 20 and 34 weeks gestation. Previous caesarean section was related to the increased odds of anterior placental implantation but no relation was seen between low-lying placenta or placenta praevia and previous caesarean...
November 11, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27853262/the-lnc-rna-spry4-it1-modulates-trophoblast-cell-invasion-and-migration-by-affecting-the-epithelial-mesenchymal-transition
#8
Qing Zuo, Shiyun Huang, Yanfen Zou, Yetao Xu, Ziyan Jiang, Shan Zou, Haoqing Xu, Lizhou Sun
Preeclampsia is a common, pregnancy-specific disease and a major contributor to maternal and foetal morbidity and mortality. Some placental abnormalities, including deficient implantation, abnormal trophoblast cell function, and improper placental vascular development, are believed to lead to preeclampsia. The long noncoding RNA SPRY4-IT1 is more highly expressed in preeclamptic human placentas than in normal placentas. We assessed the role of epithelial-mesenchymal transition (EMT)-associated invasion and migration in HTR-8/SVneo trophoblast cells...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27849611/notch1-controls-development-of-the-extravillous-trophoblast-lineage-in-the-human-placenta
#9
Sandra Haider, Gudrun Meinhardt, Leila Saleh, Christian Fiala, Jürgen Pollheimer, Martin Knöfler
Development of the human placenta and its different epithelial trophoblasts is crucial for a successful pregnancy. Besides fusing into a multinuclear syncytium, the exchange surface between mother and fetus, progenitors develop into extravillous trophoblasts invading the maternal uterus and its spiral arteries. Migration into these vessels promotes remodelling and, as a consequence, adaption of blood flow to the fetal-placental unit. Defects in remodelling and trophoblast differentiation are associated with severe gestational diseases, such as preeclampsia...
November 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27848279/a-transcriptional-switch-point-during-hematopoietic-stem-and-progenitor-cell-ontogeny
#10
Daisuke Sugiyama, Anagha Joshi, Kasem Kulkeaw, Keai Sinn Tan, Tomoko Yokoo-Inoue, Chiyo Mizuochi-Yanagi, Kaori Yasuda, Atsushi Doi, Tadafumi Iino, Masayoshi Itoh, Sayaka Nagao-Sato, Kenzaburo Tani, Koichi Akashi, Yoshihide Hayashizaki, Harukazu Suzuki, Hideya Kawaji, Piero Carninci, Alistair R R Forrest
During mammalian embryogenesis, hematopoietic stem and progenitor cells (HSPCs) originate from mesoderm-derived endothelial cells in the aorta-gonad-mesonephros (AGM) region and placenta. Later, HSPCs expand in fetal liver and migrate to bone marrow shortly before birth. Understanding global transcriptional regulation governing HSPC emergence from embryonic stem/induced pluripotent stem cells is necessary to devise clinical applications, such as novel transplantation approaches. Here, to assess transcriptional dynamics during development, we performed cap analysis of gene expression (CAGE) on 10 developmental murine HSPC populations isolated from the AGM region, placenta, fetal liver and bone marrow and identified 15,681 transcripts across HSPC ontogeny...
November 16, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27832434/monitoring-of-venus-transgenic-cell-migration-during-pregnancy-in-non-transgenic-rabbits
#11
N Lipták, O I Hoffmann, A Kerekes, G Iski, D Ernszt, K Kvell, L Hiripi, Z Bősze
Cell transfer between mother and fetus were demonstrated previously in several species which possess haemochorial placenta (e.g. in humans, mice, rats, etc.). Here we report the assessment of fetal and maternal microchimerism in non-transgenic (non-TG) New Zealand white rabbits which were pregnant with transgenic (TG) fetuses and in non-TG newborns of TG does. The TG construct, including the Venus fluorophore cDNA driven by a ubiquitous cytomegalovirus enhancer, chicken ß-actin promoter (CAGGS), was previously integrated into the rabbit genome by Sleeping Beauty transposon system...
November 10, 2016: Transgenic Research
https://www.readbyqxmd.com/read/27816668/distinct-expression-profiles-of-lncrnas-between-early-onset-preeclampsia-and-preterm-controls
#12
Wei Long, Can Rui, Xuejing Song, Xiaonan Dai, Xuan Xue, Yuanqing Lu, Rong Shen, Jun Li, Jingyun Li, Hongjuan Ding
Early-onset preeclampsia (EOPE), which is the most severe form of the syndrome, confers a high risk of neonatal morbidity and perinatal death. We aim to study the roles of long non-coding RNAs (lncRNAs) in the pathogenesis of early-onset preeclampsia (EOPE). Therefore, we examined the expression profiles of lncRNAs between early-onset preeclampsia and preterm controls using microarray analysis. Quantitative real-time PCR (qRT-PCR) was performed to verify the selected differentially expressed lncRNAs. In total, we identified 15,646 upregulated and 13,178 downregulated lncRNAs in the placenta of EOPE patients compared to the preterm controls...
December 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27806942/placental-hypoxia-during-early-pregnancy-causes-maternal-hypertension-and-placental-insufficiency-in-the-hypoxic-guinea-pig-model
#13
Loren P Thompson, Laramie Pence, Gerard Pinkas, Hong Song, Bhanu P Telugu
Chronic placental hypoxia is one of the root causes of placental insufficiencies that result in preeclampsia and maternal hypertension. Chronic hypoxia causes disruption of trophoblast (TB) development, invasion into maternal decidua, and remodeling of maternal spiral arteries. The pregnant guinea pig shares several characteristics with humans such as hemomonochorial placenta, villous subplacenta, deep TB invasion and remodeling of maternal arteries, and is an ideal animal model to study placental development...
November 2, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27754115/os-23-02-the-role-of-complement-c5a-mediated-placental-dysfunction-in-the-onset-of-preeclampsia
#14
Yu Ma, Cheng-Chao Ruan, Yu Zhang, Qian Ge, Qi-Hong Wu, Ling-Ran Kong, Ping-Jin Gao
OBJECTIVE: Women with preeclampsia (PE) display excessive activation of complement system. However, little is known about the detailed cellular and molecular mechanism of complement activation in the development of PE. Here, we hypothesized that whether complement C5a contributes to the onset of PE through its effect on trophoblasts. DESIGN AND METHOD: In this study, 23 women with established PE and 32 normotensive women were recruited. At entry, peripheral and central blood pressure and pulse wave velocity (PWV) were performed...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753932/os-05-07-role-of-soluble-endoglin-in-the-physiopathology-of-preeclampsia
#15
Jose Lopez-Novoa, Lucia Perez-Roque, Elena Nuñez-Gomez, Claudia Ollauri, Laura Ruiz-Remolina, Miguel Arevalo, Carmelo Bernabeu, Alicia Rodriguez-Barbero, Miguel Pericacho
OBJECTIVE: Preeclampsia, characterized by hypertension and proteinuria occurring after the twentieth week of pregnancy, is a major contributor to maternal and perinatal morbidity and mortality in developed countries. The mechanisms mediating the pathogenesis preeclampsia are far from clear. Strong experimental evidence suggests that placental ischemia, resulting from the inappropriate remodeling of the maternal spiral arteries, stimulates the release of soluble factors causing hypertension and renal damage...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748453/microrna-16-inhibits-feto-maternal-angiogenesis-and-causes-recurrent-spontaneous-abortion-by-targeting-vascular-endothelial-growth-factor
#16
Yongsheng Zhu, Hong Lu, Zhenghao Huo, Zhanbin Ma, Jie Dang, Wei Dang, Lin Pan, Jing Chen, Huijun Zhong
Recurrent spontaneous abortion (RSA) is a common health problem that affects women of reproductive age. Recent studies have indicated that microRNAs are important factors in miscarriage. This study investigated the role of miR-16 in regulating vascular endothelial growth factor (VEGF) expression and the pathogenesis of RSA. In this report, clinical samples revealed that miR-16 expression was significantly elevated in the villi and decidua of RSA patients. In vitro, miR-16 upregulation inhibited human umbilical vein endothelial cell proliferation, migration and tube formation...
October 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27737730/spatiotemporal-expression-profile-of-proteases-and-immunological-angiogenic-hormonal-and-apoptotic-mediators-in-rat-placenta-before-and-during-intrauterine-trophoblast-migration
#17
Juneo F Silva, Natália M Ocarino, Rogéria Serakides
The gene and/or protein expression of proteases and immunological, angiogenic, hormonal and apoptotic mediators was evaluated in rat placenta before and during intrauterine trophoblast migration. The depth of interstitial and endovascular intrauterine trophoblast invasion and the immunohistochemical expression of vascular endothelial growth factor (VEGF), fetal liver kinase 1 (Flk1), interferon (IFN)-γ, migration inhibitory factor (MIF), and inducible nitric oxide synthase (iNOS; also known as nitric oxide synthase (NOS) 2) were evaluated...
October 14, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/27714564/heat-shock-protein-27-hsp27-regulates-stat3-and-eif4g-levels-in-first-trimester-human-placenta
#18
Gali Epstein Shochet, Oded Komemi, Dana Sadeh-Mestechkin, Meir Pomeranz, Ami Fishman, Liat Drucker, Michael Lishner, Shelly Tartakover Matalon
During placental implantation, cytotrophoblast cells differentiate to extravillous trophoblast (EVT) cells that invade from the placenta into the maternal uterine blood vessels. The heat shock protein-27 (HSP27), the signal transducer and activator of transcription-3 (STAT3) and the eukaryotic translation initiation factor 4E (EIF4E) are involved in regulating EVT cell differentiation/migration. EIF4E and EIF4G compose the translation initiation complex, which is a major control point in protein translation...
October 6, 2016: Journal of Molecular Histology
https://www.readbyqxmd.com/read/27697227/dna-methylation-associated-repression-of-mest-peg1-expression-contributes-to-the-invasion-of-extravillous-trophoblast-cells
#19
Wei Peng, Ying Chen, Xin Luo, Nan Shan, Xi Lan, David Olson, Hua Zhang, Yu-Bin Ding, Hong-Bo Qi
INTRODUCTION: The invasion of extravillous cytotrophoblasts (EVTs) into the maternal uterine decidua and vasculature is critical for human placenta development and pregnancy maintenance. The imprinted gene MEST/PEG1 has been implicated in trophoblast development; however, the role of MEST in EVT invasion and the accompanying early pregnancy complications are not fully understood. METHODS: Western blot, immunofluorescence and immunohistochemistry were used to detect MEST protein expression and localization by using antibodies recognize 2 reported isoforms...
October 2016: Placenta
https://www.readbyqxmd.com/read/27697220/upregulation-of-vegf-by-small-activating-rna-and-its-implications-in-preeclampsia
#20
Xijiao Guo, Ling Feng, Jing Jia, Ruibao Chen, Jun Yu
INTRODUCTION: Preeclampsia is a severe pregnancy complication mostly due to inadequate vascular dilation and remodeling of spiral arteries. VEGF, the major factor for angiogenesis, is necessary for modulating angiogenic processes in the placenta. Hence reduction of VEGF in gestational hypertension may also lead to hypoperfusion and subsequent hypoxia of the fetus in hypertensive pregnancy. METHODS: This study aimed at elucidating the mechanism of action of VEGF in preeclampsia...
October 2016: Placenta
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