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https://www.readbyqxmd.com/read/29774963/glucocorticoid-signaling-regulates-cell-invasion-and-migration-in-the-human-first-trimester-trophoblast-cell-line-sw-71
#1
Edwina P Kisanga, Zhonghua Tang, Seth Guller, Shannon Whirledge
PROBLEM: The development of the placenta and its functions are sensitive to infection and stress, which can activate the hypothalamic-pituitary-adrenal axis. Adrenally produced glucocorticoids are the body's primary mediators of the inflammatory and stress response. Although the glucocorticoid receptor (GR) is expressed in all human villous trophoblast tissue, the effect of glucocorticoids on placentation is not well understood. METHOD OF STUDY: Using microarray analysis, we identified the glucocorticoid-regulated transcriptional profile in the immortalized first-trimester extravillous trophoblast cell line Swan...
May 18, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29773648/ten-eleven-translocation-2-demethylates-the-mmp9-promoter-and-its-down-regulation-in-preeclampsia-impairs-trophoblast-migration-and-invasion
#2
Xiaoliang Li, Chunlian Wu, Ying Shen, Ke Wang, Li Tang, Mi Zhou, Ming Yang, Tianying Pan, Xinghui Liu, Wenming Xu
Preeclampsia is the most common clinical disorder in pregnancy and might result from disordered uterine environments caused by epigenetic modifications, including deregulation of DNA methylation/demethylation. Recent research has indicated that 5-hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC) via oxidation by ten-eleven translocation (TET) enzymes, is involved in DNA methylation-related plasticity. Here, we report that TET2 expression and 5hmC abundance are significantly altered in the placentas from preeclampsia patients...
May 17, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29721663/combined-vegf-pdgf-inhibition-using-axitinib-induces-%C3%AE-sma-expression-and-a-pro-fibrotic-phenotype-in-human-pericytes
#3
Jakob Siedlecki, Ben Asani, Christian Wertheimer, Anna Hillenmayer, Andreas Ohlmann, Claudia Priglinger, Siegfried Priglinger, Armin Wolf, Kirsten Eibl-Lindner
PURPOSE: Large trials on anti-VEGF/PDGF (vascular endothelial/platelet-derived growth factor) combination therapy have been established to improve management of neovascular activity in age-related macular degeneration. Targeting pericytes, PDGF is thought to induce vessel regression and reduce fibrovascular scarring. The fate of pericytes exposed to anti-VEGF/PDGF combination therapy is not clear. Therefore, this study was designed to study the influence of anti-VEGF/PDGF on pericyte phenotype and cellular behavior...
May 2, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29718653/silk-sponges-ornamented-with-placenta-derived-extracellular-matrix-augments-full-thickness-cutaneous-wound-healing-by-stimulating-neovascularization-and-cellular-migration
#4
Arun Prabhu Rameshbabu, Kamakshi Bankoti, Sayanti Datta, Elavarasan Subramani, Anupam Apoorva, Paulomi Ghosh, Priti Prasanna Maity, Padmavati Manchikanti, Koel Chaudhury, Santanu Dhara
Regeneration of full-thickness wound without scar formation is a multifaceted process which depends on in situ dynamic interactions between the tissue-engineered skin substitutes and newly formed reparative tissue. However, the majority of the tissue-engineered skin substitutes used so far in full-thickness wound healing cannot mimic the natural extracellular matrix (ECM) complexity and thus are incapable of providing a suitable niche for endogenous tissue repair. Herein, we demonstrated a simple approach to fabricate porous Hybrid Extracellular Matrix Sponges (HEMS) using Placental Extracellular Matrix (pECM) and Silk Fibroin (SF) for full-thickness wound healing...
May 2, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29665647/mir-362-3p-regulates-cell-proliferation-migration-and-invasion-of-trophoblastic-cells-under-hypoxia-through-targeting-pax3
#5
Nan Wang, Yaling Feng, Jianjuan Xu, Jinfang Zou, Minghua Chen, Yue He, Huan Liu, Min Xue, Yanfang Gu
Preeclampsia (PE), a common obstetrical disorder, is one of the leading causes of pregnancy associated death. PE is closely linked with impaired migration and invasion ability of trophoblastic cells. miR-362-3p recently received our particular attention due not only to its aberrant expression in the placentas of patients with PE, but also to its important roles in regulating migration and invasion of various cells. This study was thus conducted to investigate the roles of miR-362-3p in PE and the related mechanism...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29665425/omega-3-polyunsaturated-fatty-acids-promotes-angiogenesis-in-placenta-derived-mesenchymal-stromal-cells
#6
Suja Ann Mathew, Ramesh Bhonde
Enhancement of angiogenesis is solicited in wound repair and regeneration. Mesenchymal stromal cells derived from the placenta (P-MSCs) have an inherent angiogenic potential. Polyunsaturated fatty acids (PUFAs) in turn, specifically the omega-3 (N-3) are essential for growth and development. They are also recommended as dietary supplements during pregnancy. We therefore hypothesized that addition of N-3 PUFAs in P-MSC culture media may enhance their angiogenic potential. Hence we treated P-MSCs with omega-3 (N-3) fatty acids -Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA) at different concentrations and tested their angiogenic potential...
April 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29662820/effects-of-selenium-on-the-survival-and-invasion-of-trophoblasts
#7
Jee Yoon Na, Jin Seok, Sohae Park, Jung Seok Kim, Gi Jin Kim
Objective: Placental oxidative stress is known to be a factor that contributes to pregnancy failure. The aim of this study was to determine whether selenium could induce antioxidant gene expression and regulate invasive activity and mitochondrial activity in trophoblasts, which are a major cell type of the placenta. Methods: To understand the effects of selenium on trophoblast cells exposed to hypoxia, the viability and invasive activity of trophoblasts were analyzed...
March 2018: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29642803/expression-of-n-acetylglucosaminyltransferase-iii-promotes-trophoblast-invasion-and-migration-in-early-human-placenta
#8
Qinyin Deng, Xiru Liu, Zhongmei Yang, Lan Xie
INTRODUCTION: Trophoblast migration and invasion at the maternal-fetal interface are crucial events for normal placentation and successful pregnancy. This progress is well controlled by many placenta-specific factors. Inadequate trophoblast invasion results in poor placenta plantation or even complications such as preeclampsia. It has been shown that N-acetylglucosaminyltransferase III (GnT-III) participates in tumor invasion and metastasis as a suppressor; however, the expression of GnT-III and its role in normal pregnancy is unclear...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29615475/micrornas-crucial-regulators-of-placental-development
#9
Heyam Hayder, Jacob O'Brien, Uzma Nadeem, Chun Peng
MicroRNAs (miRNAs) are small non-coding single-stranded RNA that are integral to a wide range of cellular processes mainly through the regulation of translation and mRNA stability of their target genes. The placenta is a transient organ that exists throughout gestation in mammals, facilitating nutrient and gas exchange and waste removal between the mother and the fetus. MiRNAs are expressed in the placenta and many studies have shown that miRNAs play an important role in regulating trophoblast differentiation, migration, invasion, proliferation, apoptosis, vasculogenesis/angiogenesis, and cellular metabolism...
April 3, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29611751/-the-pathogenetic-role-and-expression-profile-of-micrornas-in-preeclampsia
#10
Orsolya Biró, János Rigó
Preeclampsia is the leading cause of maternal and fetal morbidity and mortality that affects 3-8% of pregnancies worldwide. Its main symptoms include new onset of high blood pressure and proteinuria after 20 weeks of pregnancy. The cause of the disease is still debated. microRNAs are short, non-coding RNA molecules that play a pivotal part in the posttranscriptional regulation of eukaryotic genes. They are involved in fine-tuning of vital physiological processes such as cell cycle, proliferation, differentiation and cell death...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29596519/response-of-human-normal-and-leukemia-cells-to-factors-released-by-amnion-fragments-in-vitro
#11
Zofia Grzywocz, Grazyna Hoser, Stanislawa Sabalinska, Piotr Ladyzynski, Jaroslaw Czubak, Malgorzata Dworczynska, Romuald Debski, Ewa Pius-Sadowska, Boguslaw Machalinski, Jerzy Kawiak
Amnion is a membrane surrounding the embryo/fetus which determine growth factors and interleukins with angiogenic, immunogenic, and anti-inflammatory properties. The aim of the present study was to investigate the effects of conditioned culture medium from 24-h cultures of human amnion (hAM CCM) on migration and proliferation of human umbilical vein endothelial primary cells (HUVECs), freshly isolated bone marrow mononuclear cells (BM MNCs), and Jurkat leukemia cell line. Amnion membrane was freshly isolated from healthy placenta and its fragments cultured in vitro to produce hAM CCM...
2018: PloS One
https://www.readbyqxmd.com/read/29588191/arachidonic-acid-metabolites-of-cyp4a-and-cyp4f-are-altered-in-women-with-preeclampsia
#12
Nicole L Plenty, Jessica L Faulkner, Joshua Cotton, Shauna-Kay Spencer, Kedra Wallace, Babbette LaMarca, Sydney R Murphy
Few studies exist on cytochrome P450 (CYP450) metabolites of arachidonic acid (AA) pertaining to the pathophysiological events in pregnancy. We hypothesized that metabolism of AA via the CYP450 pathways is altered within the placenta in women with preeclampsia (PE) and contributes to the pathophysiology of the disease. Thus, placental vascular CYP450 enzyme expression and activity were measured in normal pregnant (NP) and preeclamptic (PE) patients. CYP450 isoform expression (CYP4A11, CYP4A22, CYP4F2, and CYP4F3) was found to be elevated within the placenta of women with PE compared to normal pregnant (NP) women and chronic hypertensive (CHTN) pregnant women...
March 24, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29581082/methylmercury-alters-proliferation-migration-and-antioxidant-capacity-in-human-htr8-sv-neo-trophoblast-cells
#13
Emily K Tucker, Romana A Nowak
Methylmercury, a potent neurotoxin, is able to pass through the placenta, but its effects on the placenta itself have not been elucidated. Using an immortalized human trophoblast cell line, HTR8/SV-neo, we assessed the in vitro toxicity of methylmercury. We found that 1 μg/mL methylmercury decreased viability, proliferation, and migration; and it had effects on antioxidant genes similar to those seen in neural cells. However, methylmercury led to decreased expression of superoxide dismutase 1 and increased expression of surfactant protein D...
March 23, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29567477/the-blocking-of-aquaporin-3-aqp3-impairs-extravillous-trophoblast-cell-migration
#14
Reca Alejandra, Szpilbarg Natalia, Damiano Alicia E
Several aquaporins (AQPs) are expressed in extravillous (EVT) and villous trophoblast cells. Among them, AQP3 is the most abundant AQP expressed in chorionic villi samples from first trimester, followed by AQP1 and AQP9. Although AQP3 expression persists in term placentas, it is significantly decreased in placentas from preeclamptic pregnancies. AQP3 is involved in the migration of different cell types, however its role in human placenta is still unknown. Here, we evaluated the role of AQP3 in the migration of EVT cells during early gestation...
March 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29546272/satb1-down-regulation-induced-by-oxidative-stress-participates-in-trophoblast-invasion-by-regulating-%C3%AE-catenin
#15
Haiying Rao, Yuxiang Bai, Qingshu Li, Baimei Zhuang, Yu Yuan, Yamin Liu, Wei Peng, Philip N Baker, Chao Tong, Xin Luo, Hongbo Qi
Preeclampsia (PE) is characterized by abnormal placentation in the early stages of pregnancy. Adequate migration and invasion of trophoblasts into the uterine wall and spiral arteries to form a functional maternal-fetal interface are pivotal for normal placentation, but the exact mechanism remains unclear. Growing evidence has revealed that special AT-rich sequence-binding protein 1 (SATB1) is a tumor promoter that participates in cancer cell migration and invasion. However, the expression and function of SATB1 in trophoblasts is unknown...
March 13, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29466889/downregulated-n-acetylglucosaminyltransferase-iii-is-involved-in-attenuating-trophoblast-migration-and-invasion-under-hypoxia-reoxygenation-condition
#16
Qinyin Deng, Nanlin Yin, Ying Chen, Nan Shan, Xiru Liu, Hongbo Qi
OBJECTIVE: Many studies have confirmed that N-acetylglucosaminyltransferase III (GnT-III) is correlated with tumor invasion and metastasis. However, the expression of GnT-III and its role in normal pregnancy and preeclampsia (PE) has not been reached. So the primary objective of this study is to determine GnT-III expression in normal pregnancy and whether its expression is vulnerable to oxidative stress in the trophoblast cells. METHODS: Human first trimester villous tissues from normal pregnancies and third trimester placentas from pregnancies with or without preeclampsia (PE) were used for the detection of GnT-III expression...
February 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29437897/tlr9-toll-like-receptor-9-agonist-suppresses-angiogenesis-by-differentially-regulating-vegfa-vascular-endothelial-growth-factor-a-and-sflt1-soluble-vascular-endothelial-growth-factor-receptor-1-in-preeclampsia
#17
Biwei He, Xingyu Yang, Yamei Li, Ding Huang, Xin Xu, Wenjun Yang, Yan Dai, Huijuan Zhang, Zhengjun Chen, Weiwei Cheng
Preeclampsia is a common pregnancy-specific disorder characterized by elevated blood pressure and proteinuria. Activation of the maternal immune system and impaired placental angiogenesis are thought to contribute to the pathogenesis of preeclampsia. TLR9 (Toll-like receptor 9) plays a role in innate immunity, defending the organism against infection. The purpose of this study was to determine whether TLR9 inhibits angiogenesis at the fetomaternal interface under conditions of preeclampsia. We confirmed the downregulation of VEGFA (vascular endothelial growth factor A) and upregulation of TLR9 and sFLT1 (soluble vascular endothelial growth factor receptor 1) in placentas from preeclamptic women...
April 2018: Hypertension
https://www.readbyqxmd.com/read/29436641/mir%C3%A2-203-contributes-to-pre%C3%A2-eclampsia-via-inhibition-of-vegfa-expression
#18
Fulin Liu, Kejia Wu, Wanrong Wu, Yurou Chen, Hanshu Wu, Hui Wang, Wei Zhang
Pre-eclampsia (PE) is a common but complex condition that can occur in pregnancy. It is estimated to affect 3-8% of pregnancies worldwide. PE development is thought to be multifactorial and to involve the dysregulation of microRNA (miR) expression. However, the precise mechanisms of PE development remain unclear. The present study aimed to illustrate the association between miR‑203 expression and PE development in samples of human placenta collected from mothers with (n=18) and without (n=20) PE. It was demonstrated that miR‑203 expression was significantly increased in the PE placenta compared with the normal placenta samples, while the expression of vascular endothelial growth factor A (VEGFA) was decreased...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29428958/down-regulation-of-neuropathy-target-esterase-in-preeclampsia-placenta-inhibits-human-trophoblast-cell-invasion-via-modulating-mmp-9-levels
#19
Ting Zhong, Jiaxiang Chen, Yan Ling, Bei Yang, Xingxing Xie, Dainan Yu, Dalei Zhang, Jiexiu Ouyang, Haibin Kuang
BACKGROUND/AIMS: Neuropathy target esterase (NTE, also known as neurotoxic esterase) is proven to deacylate phosphatidylcholine (PC) to glycerophosphocholine as a phospholipase B. Recently; studies showed that artificial phosphatidylserine/PC microvesicles can induce preeclampsia (PE)-like changes in pregnant mice. However, it is unclear whether NTE plays a key role in the pathology of PE, a pregnancy-related disease, which was characterized by deficient trophoblast invasion and reduced trophoblast-mediated remodeling of spiral arteries...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29410783/functional-roles-of-ornithine-decarboxylase-and-arginine-decarboxylase-during-the-peri-implantation-period-of-pregnancy-in-sheep
#20
Yasser Y Lenis, Gregory A Johnson, Xiaoqiu Wang, Wendy W Tang, Kathrin A Dunlap, M Carey Satterfield, Guoyao Wu, Thomas R Hansen, Fuller W Bazer
Background: Polyamines stimulate DNA transcription and mRNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells; therefore, they are essential for development and survival of conceptuses (embryo/fetus and placenta). The ovine conceptus produces polyamines via classical and non-classical pathways. In the classical pathway, arginine (Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase (ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine...
2018: Journal of Animal Science and Biotechnology
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