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placenta migration

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https://www.readbyqxmd.com/read/28901463/microrna-expression-profiles-and-networks-in-placentas-complicated-with-selective-intrauterine-growth-restriction
#1
Hong Wen, Lu Chen, Jing He, Jun Lin
The microRNA (miRNA) profiles of placentas complicated with selective intrauterine growth restriction (sIUGR) are unknown. In the present study, the sIUGR‑associated placental miRNA expression was investigated using microarray and confirmatory reverse transcriptase‑quantitative polymerase chain reaction studies. Placenta samples around the individual insertion region for each umbilical cord were collected from monochorionic twins complicated with (n=17) or without sIUGR (control, n=16). miRNA profile analysis was performed on two sIUGR cases and one control using an Affymetrix microRNA 4...
September 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28899975/antagonism-of-eg-vegf-receptors-as-targeted-therapy-for-choriocarcinoma-progression-in-vitro-and-in-vivo
#2
Wael Traboulsi, Frederic Sergent, Houssine Boufettal, Sophie Brouillet, Rima Slim, Pascale Hoffmann, Mohammed Benlahfid, Qun Yong Zhou, Giafranco Balboni, Valentina Onnis, Pierre-Adrien Bolze, Aude Salomon, Philippe Sauthier, François Mallet, Touria Aboussaouira, Jean-Jacques Feige, Mohamed Benharouga, Nadia Alfaidy
PURPOSE: Choriocarcinoma (CC) is the most malignant gestational trophoblastic disease that often develops from complete hydatidiform moles (CHM). Neither the mechanism of CC development nor its progression is yet characterized. We have recently identified EG-VEGF as a novel key placental growth factor that controls trophoblast proliferation and invasion. EG-VEGF acts via two receptors PROKR1 and PROKR2. Here, we demonstrate that EG-VEGF receptors can be targeted for CC therapy. EXPERIMENTAL DESIGN: Three approaches were used, i) a clinical investigation comparing circulating EG-VEGF in Control (n=20) and in distinctive CHM (n=38) and CC (n=9) cohorts, ii) an in vitro study investigating EG-VEGF effects on the CC cell line JEG3, and iii) an in vivo study including the development of a novel CC mouse model, through a direct injection of JEG3-luciferase into the placenta of gravid SCID-mice...
September 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28881663/bisphenol-a-exposure-promotes-htr-8-svneo-cell-migration-and-impairs-mouse-placentation-involving-upregulation-of-integrin-%C3%AE-1-and-mmp-9-and-stimulation-of-mapk-and-pi3k-signaling-pathways
#3
Xi Lan, Li-Juan Fu, Jun Zhang, Xue-Qing Liu, Hui-Jie Zhang, Xue Zhang, Ming-Fu Ma, Xue-Mei Chen, Jun-Lin He, Lian-Bing Li, Ying-Xiong Wang, Yu-Bin Ding
In this study, we investigated the effect of Bisphenol A (BPA), an endocrine-disrupting chemical, on the migration of human trophoblasts and mouse placentation by using the primary extravillous trophoblast (EVT) and its cell line HTR-8/SVneo, villous explant cultures, and pregnant mice. BPA increased EVT motility and the outgrowth of villous explants in a dose-dependent manner. BPA also increased the protein levels of integrin-β1 and matrix metalloproteinase (MMP)-9 in human EVTs. Low-dose BPA (≤50 mg) increased the protein levels of MMP-9 and MMP-2 as well as integrin-β1 and integrin-α5 in mouse placenta and decreased the proportion of the labyrinth and spongiotrophoblast layers...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28870404/interferon-%C3%AE-suppresses-the-proliferation-and-migration-of-human-placenta-derived-mesenchmal-stromal-cells-and-enhances-their-ability-to-induce-the-generation-of-cd4-cxcr5-foxp3-treg-subset
#4
Jun-Zhu Yi, Zheng-Hua Chen, Feng-Huang Xu, Zhuo-Ya Wang, Hong-Qin Zhang, Guo-Sheng Jiang, Xi-Ying Luan
We investigate the effects of interferon (IFN)-γ on human placenta-derived mesenchymal stromal cells (hPMSCs), in particular, their adhesion, proliferation and migration and modulatory effects on the CD4(+)CXCR5(+)Foxp3(+)Treg subset. And we compared hPMSCs ability to induce the generation of different Treg subsets in response to treatment with IFN-γ. We found that IFN-γ suppressed the proliferation and migration for hPMSCs. The ability of hPMSCs to induce the generation of CD4(+)CXCR5(+)Foxp3(+)Treg subset was enhanced by IFN-γ...
July 25, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28869810/autophagy-regulation-in-preeclampsia-pros-and-cons
#5
REVIEW
Akitoshi Nakashima, Aiko Aoki, Tae Kusabiraki, Shi-Bin Cheng, Surendra Sharma, Shigeru Saito
Autophagy is an evolutionarily conserved process in eukaryotes to maintain cellular homeostasis against stress. This process has two main functions: producing energy and quality control of intracellular proteins. During early pregnancy, extravillous trophoblasts (EVTs) invade the uterine myometrium and migrate along the lumina of spiral arterioles under hypoxic and low-nutrient conditions. Autophagy activation is observed in EVTs under these conditions, suggesting that EVTs use autophagy for adjusting to such harsh conditions...
August 26, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28826365/src-3-plays-a-critical-role-in-human-umbilical-vein-endothelial-cells-by-regulating-the-pi3k-akt-mtor-pathway-in-preeclampsia
#6
Yu Yuan, Nan Shan, Bin Tan, Qinyin Deng, Yangming Liu, Hanbin Wang, Xiaofang Luo, Chengjin He, Xin Luo, Hua Zhang, Philip N Baker, David M Olson, Hongbo Qi
Preeclampsia (PE) is currently thought to be characterized by oxidative stress which may lead to endothelial dysfunction. The normal function of vascular endothelium is essential to vascular homeostasis. Previous studies have shown that steroid receptor coactivator 3 (SRC-3) interacts with estrogen receptors (ERs) which are involved in the vasoprotective effects of estrogen and is also associated with cell migration, invasion, and inflammation; however, its role in PE remains unclear. The main purpose of this study is to identify the role of SRC-3 in the function of human umbilical vein endothelial cells (HUVECs) during the development of PE...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28826364/mir-203-participates-in-human-placental-angiogenesis-by-inhibiting-vegfa-and-vegfr2-expression
#7
Fulin Liu, Wanrong Wu, Kejia Wu, Yurou Chen, Hanshu Wu, Hui Wang, Wei Zhang
Angiogenesis during placentation is of great significance in maintaining normal pregnancy. However, the molecular mechanisms of this process are not clear. It has been reported that miR-203 plays a critical role in the development and progression of many tumors but not focused on the relationship between miR-203 and placental angiogenesis. The present study aims to illustrate the correlation between miR-203 and vascular endothelial growth factor (VEGFA)/vascular endothelial growth factor receptors 2 (VEGFR2) in human placenta and human umbilical vein endothelial cells (HUVECs) obtained from 40 samples...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28817576/gestational-diabetes-mellitus-is-associated-with-increased-pro-migratory-activation-of-vascular-endothelial-growth-factor-receptor-2-and-reduced-expression-of-vascular-endothelial-growth-factor-receptor-1
#8
Felipe Troncoso, Jesenia Acurio, Kurt Herlitz, Claudio Aguayo, Patricio Bertoglia, Enrique Guzman-Gutierrez, Marco Loyola, Marcelo Gonzalez, Meriem Rezgaoui, Gernot Desoye, Carlos Escudero
Placentas from gestational diabetes mellitus (GDM) are often hypervascularized; however, participation of vascular endothelial growth factor (VEGF) and its receptors in this placental adaptation is unclear. We aimed to test whether changes in phosphorylation of tyrosine 951 or tyrosine 1175 (pY951 or pY1175) of the vascular endothelial growth factor receptor 2 (KDR) are associated with the proangiogenic state observed in placentas from GDM. We obtained placental samples from women with normal pregnancies (n = 24) or GDM (n = 18)...
2017: PloS One
https://www.readbyqxmd.com/read/28808304/hypoxia-induced-tet1-facilitates-trophoblast-cell-migration-and-invasion-through-hif1%C3%AE-signaling-pathway
#9
Jingping Zhu, Kai Wang, Ting Li, Jiayu Chen, Dandan Xie, Xinwen Chang, Julei Yao, Jinting Wu, Qian Zhou, Yuanhui Jia, Tao Duan
Low oxygen is a typical extrinsic factor for the regulation of trophoblast biological function, including cell migration, invasion and proliferation. Ten-eleven translocation methylcytosine dioxygenase 1 (TET1), an enzyme converting 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), is transcriptionally activated by hypoxia in cancer cells. Therefore, we focus on the role of TET1 on trophoblast function in a physiologically hypoxic environment (3% oxygen), which is related to early placentation. Here, we found that TET1 was highly expressed in first trimester villi compared with normal term placentas...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800671/-outcomes-of-planned-out-of-hospital-and-low-risk-hospital-births-in-lower-saxony
#10
Antje Petersen, Lea-Marie Köhler, Christiane Schwarz, Bernhard Vaske, Mechthild M Gross
Introduction Internationally, there is debate on the safety of different birth settings inside and outside of hospitals. Low-risk women in Germany can choose where they give birth, and out-of-hospital births are especially necessary in regions lacking infrastructure. To date, national studies are required. Materials and Methods We investigated planned out-of-hospital (OH) and hospital births in Lower Saxony, Germany, in 2005. Women with a singleton fetus in the vertex position were included once they reached 34+0 gestational weeks...
August 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/28782224/prokineticin-1-is-up-regulated-by-insulin-in-decidualizing-human-endometrial-stromal-cells
#11
Dorina Ujvari, Ivika Jakson, Cecilia Oldmark, Sanaz Attarha, Twana Alkasalias, Daniel Salamon, Sebastian Gidlöf, Angelica Lindén Hirschberg
Prokineticin 1 (PROK1), a hypoxia-regulated angiogenic factor, has emerged as a crucial regulator of embryo implantation and placentation. Dysregulation of PROK1 has been linked to recurrent pregnancy loss, pre-eclampsia, foetal growth restriction and preterm birth. These pregnancy complications are common in women with obesity and polycystic ovary syndrome, i.e. conditions associated with insulin resistance and compensatory hyperinsulinaemia. We investigated the effect of insulin on PROK1 expression during in vitro decidualization...
August 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28772212/mir-144-may-regulate-the-proliferation-migration-and-invasion-of-trophoblastic-cells-through-targeting-pten-in-preeclampsia
#12
Jianping Xiao, Tao Tao, Yongxiang Yin, Li Zhao, Lan Yang, Lingqing Hu
Previous studies indicated that microRNAs (miRNAs) were aberrantly expressed in the placentas of patients with Preeclampsia (PE); however, the underlying mechanism still requires further investigation. The aim of this study is to investigate the roles of miR-144 in preeclampsia and the related mechanism. The expression of miR-144 and PTEN in 30 placentas of patients with PE and 30 normal placentas was compared; next, HTR8/SVneo cells were transfected with miR-144 mimics and miR-144 inhibitors and cultured for 48h, and the proliferation and apoptosis, cell migration and invasion of the cells were examined; furthermore, the expression PTEN, Caspase-3 and Bcl-2 was examined; next, dual luciferase reporter assay has been performed to confirm that PTEN is a direct target of miR-144; finally, HTR-8/SVneo cells were transfected with either PTEN overexpression plasmid or PTEN RNAi to determine whether knockdown or overexpression of PTEN can mimic the effect of miR-144 We have observed that the expression of miR-144 was significantly decreased and the expression of PTEN was markedly increased in placentas of patients with PE compared with normal placentas; moreover, transfection of miR-144 mimics in trophoblastic cells induced significant increase in cell proliferation, migration, invasion, and decrease in cell apoptosis, and also affected the cell cycles; on the other hand, transfection of miR-144 inhibitors has shown the opposite effects; furthermore, transient overexpression of miR-144 induced marked decrease in the expression of PTEN, Caspase-3 and increase in expression of Bcl-2 (P<0...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28765940/il%C3%A2-33-restricts-invasion-and-adhesion-of-trophoblast-cell-line-jeg3-by-downregulation-of-integrin-%C3%AE-4%C3%AE-1-and-cd62l
#13
Xiao-Hui Wang, Wei Liu, Deng-Xuan Fan, Wen-Ting Hu, Ming-Qing Li, Xiao-Yong Zhu, Li-Ping Jin
Interleukin-33 (IL-33) promotes migration of cancer cells through downregulating the expression of E-cadherin. Previous studies have demonstrated that IL‑33 stimulates the proliferation of trophoblasts. However, the effect of IL‑33 on the adhesion and invasion of trophoblasts has not been investigated in detail. In the present study, the expression of IL‑33 and its receptor, IL‑1 receptor‑like 1 (ST2), was examined in villi from women during early pregnancy using immunohistochemistry. ST2 expression on human trophoblast and choriocarcinoma cell lines JAR, BeWo, JEG3 and HTR8 was confirmed by flow cytometry (FCM) assay...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28758930/treatment-of-human-placental-choriocarcinoma-cells-with-formaldehyde-and-benzene-induced-growth-and-epithelial-mesenchymal-transition-via-induction-of-an-antioxidant-effect
#14
Hae-Miru Lee, Soo-Min Kim, Kyung-Chul Choi
Cigarette smoke (CS) causes about 480,000 deaths each year worldwide, and it is well-known to have harmful effects on the human body, leading to heart disease, stroke, lung cancer, and cardiovascular problems. In this study, the effects of formaldehyde (FA) and benzene (Bz), the main components of CS, on cell proliferation and epithelial mesenchymal transition (EMT) of JEG-3 human choriocarcinoma cells were examined to confirm the relationship between CS components and placenta carcinoma. Upon MTT assay, FA (10(-8) M to 10(-5) M) and Bz (10(-11) M to 10(-8) M) increased JEG-3 cell proliferation...
July 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28751574/expression-of-adamts13-in-normal-and-abnormal-placentae-and-its-potential-role-in-angiogenesis-and-placenta-development
#15
Juan Xiao, Yun Feng, Xueyin Li, Wei Li, Lei Fan, Jing Liu, Xue Zeng, Kaiyue Chen, Xi Chen, Xiaoshui Zhou, X Long Zheng, Suhua Chen
OBJECTIVE: ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 repeats, member 13) is primarily synthesized in liver. The biosynthesis of ADAMTS13 and its physiological role in placenta are not known. APPROACH AND RESULTS: We used real-time polymerase chain reaction, immunohistochemistry, and Western blotting analyses, as well as proteolytic cleavage of FRETS (fluorescent resonance energy transfers)-VWF73, to determine ADAMTS13 expression in placenta and trophoblasts obtained from individuals with normal pregnancy and patients with severe preeclampsia...
September 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28714012/knockdown-of-jarid2-inhibits-the-viability-and-migration-of-placenta-trophoblast-cells-in-preeclampsia
#16
Yatao Jiang, Yuqing Chen, Yanping Chen
Protein Jumonji (JARID2) is a member of the Jumonji family of proteins and has been demonstrated to regulate cell proliferation and invasion. However, little is known about the role of JARID2 in the metastasis of placenta trophoblast cells. In the present study, the effect and the underlying molecular mechanism of JARID2 on trophoblast cell viability and invasion was investigated. The expression of JARID2 in placental tissues was analyzed by reverse transcription‑quantitative polymerase chain reaction and western blotting...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28708243/the-depletion-of-marveld1-leads-to-murine-placenta-accreta-via-integrin-%C3%AE-4-dependent-trophoblast-cell-invasion
#17
Yue Chen, Hui Zhang, Fang Han, Lei Yue, Chunxiao Qiao, Yao Zhang, Peng Dou, Weizhe Liu, Yu Li
The placenta is a remarkable organ, it serves as the interface between the mother and the fetus. Proper invasion of trophoblast cells is required for a successful pregnancy. Previous studies have found that the adhesion molecule integrin β4 plays important roles during trophoblast cell invasion. Here, we found that the overall birth rate of the MARVELD1 knockout mouse is much lower than that of the wild-type mouse (P<0.001). In E18.5 MARVELD1 knockout mice, we observed an over-invasion of trophoblast cells, and indeed, the pregnant mice had a partial placenta accreta phenotype...
July 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28697979/the-effect-of-endothelial-cell-activation-and-hypoxia-on-placental-chorionic-mesenchymal-stem-stromal-cell-migration
#18
Balta Al-Sowayan, Rosemary J Keogh, Mohammed Abumaree, Harry M Georgiou, Bill Kalionis
INTRODUCTION: Chorionic mesenchymal stem/stromal cells (CMSC) can be isolated from the placenta in large numbers. Although their functions are yet to be fully elucidated, they have a role in tissue development and repair. To fulfil such a role, CMSC must be able to migrate to the microenvironment of the injury site. This process is not fully understood and the aim of this study therefore, was to examine in vitro CMSC migration in response to tissue inflammation and hypoxic conditioning...
June 27, 2017: Placenta
https://www.readbyqxmd.com/read/28679316/mesenchymal-stem-multipotent-stromal-cells-from-human-decidua-basalis-reduce-endothelial-cell-activation
#19
Manal A Alshabibi, Al Joharah Al Huqail, Tanvir Khatlani, Fawaz M Abomaray, Ahmed S Alaskar, Abdullah O Alawad, Bill Kalionis, Mohamed Hassan Abumaree
Recently, we reported the isolation and characterization of mesenchymal stem cells from the decidua basalis of human placenta (DBMSCs). These cells express a unique combination of molecules involved in many important cellular functions, which make them good candidates for cell-based therapies. The endothelium is a highly specialized, metabolically active interface between blood and the underlying tissues. Inflammatory factors stimulate the endothelium to undergo a change to a proinflammatory and procoagulant state (ie, endothelial cell activation)...
September 15, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28676532/decreased-pgf-may-contribute-to-trophoblast-dysfunction-in-fetal-growth-restriction
#20
Weibin Wu, Yueying Xu, Weiwei Cheng, Bo Yuan, Jiuru Zhao, Yanlin Wang, Huijuan Zhang
Fetal growth restriction (FGR) threatens perinatal health and is correlated with increased incidence of fetal-original adult diseases. Most cases of FGR were idiopathic, which were supposed to be associated with placental abnormality. Decreased circulating placental growth factor (PGF) was recognized as an indication of placental deficiency in FGR. In this study, the epigenetic regulation of PGF in FGR placentas and the involvement of PGF in modulation of trophoblast activity were investigated. The expression level of PGF in placental tissues was determined by RT-qPCR, immunohistochemistry and ELISA assay...
July 4, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
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