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https://www.readbyqxmd.com/read/28625273/development-of-a-core-outcome-set-for-disease-modification-trials-in-mild-to-moderate-dementia-a-systematic-review-patient-and-public-consultation-and-consensus-recommendations
#1
Lucy Webster, Derek Groskreutz, Anna Grinbergs-Saull, Rob Howard, John T O'Brien, Gail Mountain, Sube Banerjee, Bob Woods, Robert Perneczky, Louise Lafortune, Charlotte Roberts, Jenny McCleery, James Pickett, Frances Bunn, David Challis, Georgina Charlesworth, Katie Featherstone, Chris Fox, Claire Goodman, Roy Jones, Sallie Lamb, Esme Moniz-Cook, Justine Schneider, Sasha Shepperd, Claire Surr, Jo Thompson-Coon, Clive Ballard, Carol Brayne, Orlaith Burke, Alistair Burns, Linda Clare, Peter Garrard, Patrick Kehoe, Peter Passmore, Clive Holmes, Ian Maidment, Fliss Murtagh, Louise Robinson, Gill Livingston
BACKGROUND: There is currently no disease-modifying treatment available to halt or delay the progression of the disease pathology in dementia. An agreed core set of the best-available and most appropriate outcomes for disease modification would facilitate the design of trials and ensure consistency across disease modification trials, as well as making results comparable and meta-analysable in future trials. OBJECTIVES: To agree a set of core outcomes for disease modification trials for mild to moderate dementia with the UK dementia research community and patient and public involvement (PPI)...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28613913/hypersensitivity-pneumonitis-a-perspective-from-members-of-the-pulmonary-pathology-society
#2
Ross Miller, Timothy Craig Allen, Roberto J Barrios, Mary Beth Beasley, Louise Burke, Philip T Cagle, Vera Luiza Capelozzi, Yimin Ge, Lida P Hariri, Keith M Kerr, Andras Khoor, Brandon T Larsen, Eugene J Mark, Osamu Matsubara, Mitra Mehrad, Mari Mino-Kenudson, Kirtee Raparia, Anja Christiane Roden, Prudence Russell, Frank Schneider, Lynette M Sholl, Maxwell Lawrence Smith
CONTEXT: - Hypersensitivity pneumonitis (HP) is a lung disease that develops in susceptible individuals after inhalational exposure to an organic antigen or chemical compound. Pathogenesis is attributed to a combination of type III (immune complex-mediated) and type IV (delayed) hypersensitivity reactions to the inciting agent. OBJECTIVE: - To provide an overview of the current status of the medical literature regarding hypersensitivity pneumonitis. DATA SOURCES: - A literature search was performed using PubMed and Google search engines...
June 14, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28583617/totally-implantable-intravenous-treprostinil-therapy-in-pulmonary-hypertension-assessment-of-the-implantation-procedure
#3
Aaron B Waxman, Hugh T McElderry, Mardi Gomberg-Maitland, Martin C Burke, Edgar L Ross, Malcolm M Bersohn, Sanjog S Pangarkar, James H Tarver, Diane L Zwicke, Jeremy P Feldman, Murali M Chakinala, Robert P Frantz, Geoffrey B Thompson, Fernando Torres, Richard L Rauck, Kathy Clagg, Louise Durst, Pei Li, Marty Morris, Kara L Southall, Leigh Peterson, Robert C Bourge
BACKGROUND: Prostacyclins improve symptoms and survival in pulmonary arterial hypertension (PAH). In response to risks associated with external delivery systems, an implantable intravenous infusion system was developed. A multicenter, prospective, single-arm, clinical trial (DelIVery for PAH) was conducted to evaluate this system for treprostinil in PAH. This analysis describes the findings related to the implant procedure. METHODS: Patients (n=64) with PAH (WHO Group 1) receiving stable intravenous treprostinil were enrolled...
June 2, 2017: Chest
https://www.readbyqxmd.com/read/28447834/perspectives-of-low-income-chronically-ill-patients-on-complex-care-management
#4
Alice Y Mao, Rachel Willard-Grace, Leslie Dubbin, Louise Aronson, Alicia Fernandez, Nancy J Burke, Julia Finch, Elizabeth Davis
INTRODUCTION: Low-income, chronically ill adults disproportionately experience poor health outcomes despite increased health care use and costs. Complex care management (CCM) programs are an innovative approach to improving outcomes for these patients, but little is known about the patients' experiences in CCM programs in safety net primary care settings. METHOD: The authors conducted semistructured interviews with 13 CCM participants in a safety net primary care clinic to explore their perceptions of their health and their experiences with CCM...
April 27, 2017: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/28410328/manipulation-of-muscle-creatine-and-glycogen-changes-dual-x-ray-absorptiometry-estimates-of-body-composition
#5
Julia L Bone, Megan L Ross, Kristyen A Tomcik, Nikki A Jeacocke, Will G Hopkins, Louise M Burke
Standardizing a dual x-ray absorptiometry (DXA) protocol is thought to provide a reliable measurement of body composition. PURPOSE: We investigated the effects of manipulating muscle glycogen and creatine content independently and additively on DXA estimates of lean mass. METHOD: Eighteen well-trained male cyclists undertook a parallel group application of creatine loading (n = 9) (20 g·d for 5 d loading; 3 g·d maintenance) or placebo (n = 9) with crossover application of glycogen loading (12 v 6 g·kg BM per day for 48 h) as part of a larger study involving a glycogen-depleting exercise protocol...
May 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28409396/factors-influencing-the-post-exercise-hepcidin-25-response-in-elite-athletes
#6
Peter Peeling, Alannah K A McKay, David B Pyne, Kym J Guelfi, Rachel H McCormick, Coby M Laarakkers, Dorine W Swinkels, Laura A Garvican-Lewis, Megan L R Ross, Avish P Sharma, Jill J Leckey, Louise M Burke
PURPOSE: The extent to which hepcidin regulation after acute bouts of exercise is influenced by baseline (resting) concentrations of key iron parameters remains uncertain. This investigation explored the influence of selected iron parameters and 25-km race walk time on 3-h post-exercise hepcidin-25 levels in international-level race walkers. METHODS: Twenty-four male race walkers completed a graded exercise test and a 25-km race-walk trial. Throughout the 25-km race-walk, venous blood samples were collected pre-exercise, immediately post-exercise, and at 3-h post-exercise...
April 13, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28387576/dietary-microperiodization-in-elite-female-and-male-runners-and-race-walkers-during-a-block-of-high-intensity-precompetition-training
#7
Ida A Heikura, Louise M Burke, Antti A Mero, Arja Leena Tuulia Uusitalo, Trent Stellingwerff
We investigated one week of dietary microperiodization in elite female (n = 23) and male (n = 15) runners and race-walkers by examining the frequency of training sessions and recovery periods conducted with recommended carbohydrate (CHO) and protein availability. Food and training diaries were recorded in relation to HARD (intense or >90min sessions; KEY) versus RECOVERY days (other-than KEY sessions; EASY). The targets for amount and timing of CHO and protein around KEY sessions were based on current nutrition recommendations...
August 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28385561/a-multifactorial-evaluation-of-illness-risk-factors-in-athletes-preparing-for-the-summer-olympic-games
#8
Michael K Drew, Nicole Vlahovich, David Hughes, Renee Appaneal, Kirsten Peterson, Louise Burke, Bronwen Lundy, Mary Toomey, David Watts, Gregory Lovell, Stephan Praet, Shona Halson, Candice Colbey, Silvia Manzanero, Marijke Welvaert, Nic West, David B Pyne, Gordon Waddington
OBJECTIVES: Illness can disrupt training and competition performance of athletes. Few studies have quantified the relative contribution of the known medical, behavioural and lifestyle risk factors. DESIGN: Cross-sectional. METHODS: Olympic athletes from 11 sports (n=221) were invited to complete questionnaires administered nine months before the Rio 2016 Olympic Games. These included the Depression, Anxiety and Stress Questionnaire (DASS-21), Perceived Stress Scale (PSS), Dispositional Resilience Scale (DRS), Recovery-Stress Questionnaire (REST-Q-52 item), Low Energy in Females Questionnaire (LEAF-Q), a modified Personal and Household Hygiene questionnaire, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and custom-made questionnaires on probiotic usage and travel...
March 21, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28338358/a-mismatch-between-athlete-practice-and-current-sports-nutrition-guidelines-among-elite-female-and-male-middle-and-long-distance-athletes
#9
Ida A Heikura, Trent Stellingwerff, Antti A Mero, Arja Leena Tuulia Uusitalo, Louise M Burke
Contemporary nutrition guidelines promote a variety of periodized and time-sensitive recommendations, but current information regarding the knowledge and practice of these strategies among world-class athletes is limited. The aim of this study was to investigate this theme by implementing a questionnaire on dietary periodization practices in national/international level female (n = 27) and male (n = 21) middle- and long-distance runners/race-walkers. The questionnaire aimed to gain information on between and within-day dietary choices, as well as timing of pre- and posttraining meals and practices of training with low or high carbohydrate (CHO) availability...
August 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28332111/practical-issues-in-evidence-based-use-of-performance-supplements-supplement-interactions-repeated-use-and-individual-responses
#10
REVIEW
Louise M Burke
Current sports nutrition guidelines recommend that athletes only take supplements following an evidence-based analysis of their value in supporting training outcomes or competition performance in their specific event. While there is sound evidence to support the use of a few performance supplements under specific scenarios (creatine, beta-alanine, bicarbonate, caffeine, nitrate/beetroot juice and, perhaps, phosphate), there is a lack of information around several issues needed to guide the practical use of these products in competitive sport...
March 2017: Sports Medicine
https://www.readbyqxmd.com/read/28316263/individualised-dietary-strategies-for-olympic-combat-sports-acute-weight-loss-recovery-and-competition-nutrition
#11
Reid Reale, Gary Slater, Louise M Burke
Olympic combat sports separate athletes into weight divisions, in an attempt to reduce size, strength, range and/or leverage disparities between competitors. Official weigh-ins are conducted anywhere from 3 and up to 24 h prior to competition ensuring athletes meet weight requirements (i.e. have 'made weight'). Fighters commonly aim to compete in weight divisions lower than their day-to-day weight, achieved via chronic and acute manipulations of body mass (BM). Although these manipulations may impair health and absolute performance, their strategic use can improve competitive success...
July 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28301302/communicating-sports-science-in-the-age-of-the-twittersphere
#12
Louise M Burke
No abstract text is available yet for this article.
February 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28221989/evaluation-of-a-multiplex-pcr-assay-for-the-identification-of-salmonella-serovars-enteritidis-and-typhimurium-using-retail-and-abattoir-samples
#13
Dele Ogunremi, Susan Nadin-Davis, Andrée Ann Dupras, Imelda Gálvan Márquez, Katayoun Omidi, Louise Pope, John Devenish, Teresa Burke, Ray Allain, Daniel Leclair
A multiplex PCR was developed to identify the two most common serovars of Salmonella causing foodborne illness in Canada, namely, serovars Enteritidis and Typhimurium. The PCR was designed to amplify DNA fragments from four Salmonella genes, namely, invA gene (211-bp fragment), iroB gene (309-bp fragment), Typhimurium STM 4497 (523-bp fragment), and Enteritidis SE147228 (612-bp fragment). In addition, a 1,026-bp ribosomal DNA (rDNA) fragment universally present in bacterial species was included in the assay as an internal control fragment...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28063614/analysis-of-emergency-department-length-of-stay-for-mental-health-patients-at-ten-massachusetts-emergency-departments
#14
Mark D Pearlmutter, Kristin H Dwyer, Laura G Burke, Niels Rathlev, Louise Maranda, Greg Volturo
STUDY OBJECTIVE: Prolonged boarding times in the emergency department (ED) disproportionately affect mental health patients, resulting in patient and provider dissatisfaction and increased patient morbidity and mortality. Our objective is to quantify the burden of mental health boarding and to elucidate the effect of insurance together with demographic, social, and comorbid factors on length of stay. METHODS: We conducted a cross-sectional observational study of 871 consecutive patients requiring an ED mental health evaluation at one of 10 unaffiliated Massachusetts hospitals...
December 30, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28012184/low-carbohydrate-high-fat-diet-impairs-exercise-economy-and-negates-the-performance-benefit-from-intensified-training-in-elite-race-walkers
#15
Louise M Burke, Megan L Ross, Laura A Garvican-Lewis, Marijke Welvaert, Ida A Heikura, Sara G Forbes, Joanne G Mirtschin, Louise E Cato, Nicki Strobel, Avish P Sharma, John A Hawley
KEY POINTS: Three weeks of intensified training and mild energy deficit in elite race walkers increases peak aerobic capacity independent of dietary support. Adaptation to a ketogenic low carbohydrate, high fat (LCHF) diet markedly increases rates of whole-body fat oxidation during exercise in race walkers over a range of exercise intensities. The increased rates of fat oxidation result in reduced economy (increased oxygen demand for a given speed) at velocities that translate to real-life race performance in elite race walkers...
May 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/27898642/manipulation-of-muscle-creatine-and-glycogen-changes-dxa-estimates-of-body-composition
#16
Julia L Bone, Megan L Ross, Kristyen A Tomcik, Nikki A Jeacocke, Will G Hopkins, Louise M Burke
Standardising a dual x-ray absorptiometry (DXA) protocol is thought to provide a reliable measurement of body composition. PURPOSE: We investigated the effects of manipulating muscle glycogen and creatine content independently and additively on DXA estimates of lean mass. METHOD: Eighteen well-trained male cyclists undertook a parallel group application of creatine loading (n=9) (20 g/d for 5 d loading; 3 g/d maintenance) or placebo (n=9) with crossover application of glycogen loading (12 v 6 g/kg BM/d for 48 h) as part of a larger study involving a glycogen-depleting exercise protocol...
November 28, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27897989/periodization-of-carbohydrate-intake-short-term-effect-on-performance
#17
Laurie-Anne Marquet, Christophe Hausswirth, Odeline Molle, John A Hawley, Louise M Burke, Eve Tiollier, Jeanick Brisswalter
BACKGROUND: "Sleep-low" consists of a sequential periodization of carbohydrate (CHO) availability-low glycogen recovery after "train high" glycogen-depleting interval training, followed by an overnight-fast and light intensity training ("train low") the following day. This strategy leads to an upregulation of several exercise-responsive signaling proteins, but the chronic effect on performance has received less attention. We investigated the effects of short-term exposure to this strategy on endurance performance...
November 25, 2016: Nutrients
https://www.readbyqxmd.com/read/27834565/weight-re-gain-is-not-linked-to-success-in-a-real-life-multi-day-boxing-tournament
#18
Reid Reale, Gregory R Cox, Gary Slater, Louise M Burke
PURPOSE: Combat sport athletes acutely reduce body mass (BM) prior to weigh-in in an attempt to gain a size/strength advantage over smaller opponents. Few studies have investigated these practices among boxers and none have explored the impact of this practice on competitive success. METHODS: One hundred (30♀/70♂) elite boxers participating in the Australian National Championships were weighed at the official weigh-in and an hour before each competition bout...
November 11, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27834492/single-and-combined-effects-of-beetroot-crystals-and-sodium-bicarbonate-on-4-km-cycling-time-trial-performance
#19
Marcus J Callahan, Evelyn B Parr, John A Hawley, Louise M Burke
When ingested alone, beetroot juice and sodium bicarbonate are ergogenic for high-intensity exercise performance. This study sought to determine the independent and combined effects of these supplements. Eight endurance trained (VO2max 65 mL·kg·min(-1)) male cyclists completed four × 4-km time trials (TT) in a doubleblind Latin square design supplementing with beetroot crystals (BC) for 3 days (15 g·day(-1) + 15 g 1 h before TT, containing 300 mg nitrate per 15 g), bicarbonate (Bi 0.3 g·kg(-1) body mass [BM] in 5 doses every 15 min from 2...
June 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27828972/coral-reefs-and-people-in-a-high-co2-world-where-can-science-make-a-difference-to-people
#20
Linwood Pendleton, Adrien Comte, Chris Langdon, Julia A Ekstrom, Sarah R Cooley, Lisa Suatoni, Michael W Beck, Luke M Brander, Lauretta Burke, Josh E Cinner, Carolyn Doherty, Peter E T Edwards, Dwight Gledhill, Li-Qing Jiang, Ruben J van Hooidonk, Louise Teh, George G Waldbusser, Jessica Ritter
REEFS AND PEOPLE AT RISK: Increasing levels of carbon dioxide in the atmosphere put shallow, warm-water coral reef ecosystems, and the people who depend upon them at risk from two key global environmental stresses: 1) elevated sea surface temperature (that can cause coral bleaching and related mortality), and 2) ocean acidification. These global stressors: cannot be avoided by local management, compound local stressors, and hasten the loss of ecosystem services. Impacts to people will be most grave where a) human dependence on coral reef ecosystems is high, b) sea surface temperature reaches critical levels soonest, and c) ocean acidification levels are most severe...
2016: PloS One
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