keyword
https://read.qxmd.com/read/38511768/serum-autophagy-related-gene-5-level-in-stroke-patients-correlation-with-cd4-t-cells-and-cognition-impairment-during-a-3-year-follow-up
#21
JOURNAL ARTICLE
Juanjuan Qu, Linxia Wu, Meng Zhang, Minchen Kan, Huimin Chen, Yanqing Shi, Shuangyu Wang, Xiaohua Wang, Fan Chen
Autophagy-related gene (ATG) 5 regulates blood lipids, chronic inflammation, CD4+ T-cell differentiation, and neuronal death and is involved in post-stroke cognitive impairment. This study aimed to explore the correlation of serum ATG5 with CD4+ T cells and cognition impairment in stroke patients. Peripheral blood was collected from 180 stroke patients for serum ATG5 and T helper (Th) 1, Th2, Th17, and regulatory T (Treg) cell detection via enzyme-linked immunosorbent assays and flow cytometry. The Mini-Mental State Examination (MMSE) scale was completed at enrollment, year (Y)1, Y2, and Y3 in stroke patients...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38511558/extracellular-vesicles-from-virulent-p-brasiliensis-induce-tlr4-and-dectin-1-expression-in-innate-cells-and-promote-enhanced-th1-th17-response
#22
JOURNAL ARTICLE
Bruno Montanari Borges, Monique Gama de Santana, Nycolas Willian Preite, Valéria de Lima Kaminski, Gabriel Trentin, Fausto Almeida, Flávio Vieira Loures
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that transport several biomolecules and are involved in important mechanisms and functions related to the pathophysiology of fungal diseases. EVs from Paracoccidioides brasiliensis , the main causative agent of Paracoccidioidomycosis (PCM), modulate the immune response of macrophages. In this study, we assessed the EVs proteome from a virulent P. brasiliensis isolated from granulomatous lesions and compared their immunomodulatory ability with EVs isolated from the fungus before the animal passage (control EVs) when challenging macrophages and dendritic cells (DCs)...
December 2024: Virulence
https://read.qxmd.com/read/38504979/the-effect-of-sars-cov-2-infection-and-vaccination-on-th17-and-regulatory-t-cells-in-a-pregnancy-cohort-in-nyc
#23
JOURNAL ARTICLE
Frederieke A J Gigase, Mara Graziani, Juliana Castro, Corina Lesseur, Anna-Sophie Rommel, Tammy Flores, M Mercedes Perez-Rodriguez, Siobhan Dolan, Joanne Stone, Teresa Janevic, Whitney Lieb, Veerle Bergink, Lot D de Witte
Disturbances in T-cells, specifically the Th17/Treg balance, have been implicated in adverse pregnancy outcomes. We investigated these two T-cell populations following pre-pregnancy and pregnancy SARS-CoV-2 infection and COVID-19 vaccination in 351 participants from a pregnancy cohort in New York City (Generation C; 2020-2022). SARS-CoV-2 infection status was determined via laboratory or medical diagnosis and COVID-19 vaccination status via survey and electronic medical records data. Peripheral blood mononuclear cells (PBMCs) were collected at routine prenatal visits throughout gestation (median 108 days; IQR 67-191 days) with repeated measures for 104 participants (29...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38503076/the-role-of-innate-and-adaptive-immunity-in-endometriosis
#24
REVIEW
Khaleque N Khan, Sun-Wei Guo, Kanae Ogawa, Akira Fujishita, Taisuke Mori
The innate and adaptive immune systems are the two key branches that determine host protection at all mucosal surfaces in human body, including the female reproductive tract. The pattern recognition receptors within the host that recognize pathogen-associated molecular patterns are expressed on the cells of the innate immune system. Rapidly reactive, theinnate immune system, responds immediately to the presence of infectious or other non-self agents, thereby launching an inflammatory response to protect the host until the activation of slower adaptive immune system...
March 13, 2024: Journal of Reproductive Immunology
https://read.qxmd.com/read/38503017/interleukin-2-anti-interleukin-2-complex-attenuates-inflammation-in-a-mouse-copd-model-by-expanding-cd4-cd25-foxp3-regulatory-t-cells
#25
JOURNAL ARTICLE
Ruirui Duan, Ke Huang, Tao Yu, Chenli Chang, Xu Chu, Yuhang Huang, Zhoude Zheng, Linxi Ma, Baicun Li, Ting Yang
BACKGROUND AND PURPOSE: Chronic, nonspecific inflammation of the alveoli and airways is an important pathological feature of chronic obstructive pulmonary disease (COPD), while sustained inflammatory reactions can cause alveolar damage. Regulatory T cells (Tregs) inhibit inflammation, whereas the interleukin-2/anti-interleukin-2 complex (IL-2C) increases the number of Tregs; however, whether the IL-2C has a therapeutic role in COPD remains unknown. Therefore, this study investigated whether IL-2C alleviates lung inflammation in COPD by increasing the number of Tregs...
March 18, 2024: International Immunopharmacology
https://read.qxmd.com/read/38502145/-bacteroides-thetaiotaomicron-and-faecalibacterium-prausnitzii-served-as-key-components-of-fecal-microbiota-transplantation-to-alleviate-colitis
#26
JOURNAL ARTICLE
Binqiang Xu, Yang Fu, Nuoming Yin, Wenfei Qin, Zehua Huang, Wei Xiao, Huizhen Huang, Qixiang Mei, Junjie Fan, Yue Zeng, Chunlan Huang
Fecal microbiota transplantation (FMT) is a promising therapy for inflammatory bowel disease (IBD) via rectifying gut microbiota. The aim of this study was to identify a mechanism of how specific bacteria-associated immune response contributes to alleviated colitis. 40 donors were divided into high (donor-H) and low (donor-L) groups according to diversity and the abundance of Bacteroides and Faecalibacterium by 16S rRNA sequencing. FMT was performed on dextran sulfate sodium (DSS)-induced colitis in mice. Mice with colitis showed significant improvement in intestinal injury and immune imbalance after FMT with group donor-H ( p <0...
March 19, 2024: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://read.qxmd.com/read/38500881/blocking-the-ctla-4-and-pd-1-pathways-during-pulmonary-paracoccidioidomycosis-improves-immunity-reduces-disease-severity-and-increases-the-survival-of-infected-mice
#27
JOURNAL ARTICLE
Nycolas Willian Preite, Bruno Montanari Borges, Valéria de Lima Kaminski, Marina Caçador Ayupe, Leonardo Mandu Gonçalves, Bianca Vieira Dos Santos, Dennyson Leandro M Fonseca, Igor Salerno Filgueiras, Caio Loureiro Salgado, Sandra Marcia Muxel, Otavio Cabral-Marques, Denise Morais da Fonseca, Flávio Vieira Loures, Vera Lúcia Garcia Calich
Immune checkpoint pathways, i.e., coinhibitory pathways expressed as feedback following immune activation, are crucial for controlling an excessive immune response. Cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed cell death protein-1 (PD-1) are the central classical checkpoint inhibitory (CPI) molecules used for the control of neoplasms and some infectious diseases, including some fungal infections. As the immunosuppression of severe paracoccidioidomycosis (PCM), a chronic granulomatous fungal disease, was shown to be associated with the expression of coinhibitory molecules, we hypothesized that the inhibition of CTLA-4 and PD-1 could have a beneficial effect on pulmonary PCM...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495876/leukemic-mutation-flt3-itd-is-retained-in-dendritic-cells-and-disrupts-their-homeostasis-leading-to-expanded-th17-frequency
#28
JOURNAL ARTICLE
Patrick A Flynn, Mark D Long, Yoko Kosaka, Nicola Long, Jessica S Mulkey, Jesse L Coy, Anupriya Agarwal, Evan F Lind
Dendritic cells (DC) are mediators between innate and adaptive immune responses to pathogens and tumors. DC development is determined by signaling through the receptor tyrosine kinase Fms-like tyrosine kinase 3 (FLT3) in bone marrow myeloid progenitors. Recently the naming conventions for DC phenotypes have been updated to distinguish between "Conventional" DCs (cDCs) and plasmacytoid DCs (pDCs). Activating mutations of FLT3, including Internal Tandem Duplication (FLT3-ITD), are associated with poor prognosis for acute myeloid leukemia (AML) patients...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38494386/suppressor-t-helper-type-17-cell-responses-in-intestinal-transplant-recipients-with-allograft-rejection
#29
JOURNAL ARTICLE
Leonid Belyayev, Jiman Kang, Mohammed Sadat, Katrina Loh, Digvijay Patil, Vinona Muralidaran, Khalid Khan, Stuart Kaufman, Sukanya Subramanian, Yuriy Gusev, Krithika Bhuvaneshwar, Habtom Ressom, Rency Varghese, Udeme Ekong, Cal S Matsumoto, Simon C Robson, Thomas M Fishbein, Alexander Kroemer
BACKGROUND: Intestinal transplant (ITx) rejection is associated with memory T helper type 17 cell (Th17) infiltration of grafted tissues. Modulation of Th17 effector cell response is facilitated by T regulatory (Treg) cells, but a phenotypic characterization of this process is lacking in the context of allograft rejection. METHODS: Flow cytometry was performed to examine the expression of surface receptors, cytokines, and transcription factors in Th17 and Treg cells in ITx control (n = 34) and rejection patients (n = 23)...
March 16, 2024: Human Immunology
https://read.qxmd.com/read/38492341/hif-1%C3%AE-induced-by-hypoxic-condition-regulates-treg-th17-axis-polarization-in-chronic-immune-thrombocytopenia
#30
JOURNAL ARTICLE
Hao Gu, Zhifa Wang, Xingjuan Xie, Hui Chen, Juntao Ouyang, Runhui Wu, Zhenping Chen
Immune thrombocytopenia (ITP) is an acquired immune disorder characterized by increased platelet destruction and reduced platelet (Plt) production. Hypoxia-inducible factor-1α (HIF-1α) have regulatory effects on Treg/Th17 axis balance and may represent relevant factors in the pathogenesis of ITP. Treg/Th17 ratio, serum levels and gene expression were investigated in new diagnosed ITP (NITP) and chronic ITP (CITP). The Treg/Th17 ratio obviously decreased in CITP (P = 0.001). The ratio of Treg/Th17 was correlated with the level of HIF-1α level both in mRNA (r = 0...
March 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38489115/modulation-of-t-cell-differentiation-in-mice-with-copd-combined-with-lung-cancer-through-key-targets-of-pd-1-by-tao-hong-si-wu-tang
#31
JOURNAL ARTICLE
Guoli Wang, Ge Wang, Keming Zhao, Aifeng Sui, Lina Wang, Yanling Xu, Nini Qu, Xiande Ma, Hu Deng
The objective is to assess the anti-inflammatory effect of Tao Hong Si Wu Tang combined with anti-PD-1 in a mouse model of COPD combined with lung cancer, elucidating its mechanism through modulation of PD-1/PD-L binding, regulation of Th1/Th2 and Th17/Treg balance, inhibition of IL-4 and IL-17, and promotion of IFN-γ and TGF-β levels in peripheral blood. One hundred male C57/BL6 mice were randomly allocated to five groups: A (blank control), B (model control), C (THSW), D (anti-PD-1), and E (THSW + anti-PD-1), with 20 mice in each group...
March 15, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38488697/undaria-pinnatifida-ameliorates-nasal-inflammation-by-inhibiting-eosinophil-and-mast-cell-activation-and-modulating-the-nf-%C3%AE%C2%BAb-mapks-signaling-pathway
#32
JOURNAL ARTICLE
Zhen Nan Yu, Yan Jing Fan, Thi Van Nguyen, Chun Hua Piao, Byung-Hoo Lee, So-Young Lee, Hee Soon Shin, Chang Ho Song, Ok Hee Chai
BACKGROUND: Allergic rhinitis (AR) is the most prevalent form of atopic disease. Undaria pinnatifida has potent antioxidative, antidiabetic, and anti-inflammatory properties. AIMS: We investigated the immunomodulatory effect of Undaria pinnatifida extract (UPE) on allergic inflammation in an AR mouse model. MATERIALS & METHODS: Mice were sensitized and intranasally challenged with ovalbumin (OVA), and the Th1/Th2 and Th17/Treg-related cytokines and histopathology were exanimated after UPE treatments...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38485905/unraveling-the-impact-of-blood-transfusion-on-transcription-factors-regulating-t-helper-1-2-17-and-regulatory-t-cells
#33
JOURNAL ARTICLE
Samad Valizadeh, Azita Chegini, Faranak Behnaz, Ali Akbar Pourfatollah, Shahram Samiee, Ronak Karbalaeifar
T helper 1 (TH1) and TH2 lymphocytes are the most important components of the immune system affected by blood transfusion. This study aimed`` to evaluate the effect of blood transfusion on gene expression of transcription factors related to the development of TH1, TH2, TH17 and regulatory T cells (Tregs). In this cross-sectional study, 20 patients diagnosed with abdominal aortic aneurysms requiring surgical repair were studied from January 2018 to August 2020. We utilized real-time PCR to evaluate the expression of transcription factor genes associated with TH1, TH2, TH17, and Treg, namely T-box-expressed-in-T-cells (T-bet), GATA-binding protein 3 (GATA-3), retinoid-related orphan receptor (RORγt), and fork head box protein 3 (Foxp3), respectively...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38479724/rho-kinase-inhibitor-alleviates-cd4-t-cell-mediated-corneal-graft-rejection-by-modulating-its-stat3-and-stat5-activation
#34
JOURNAL ARTICLE
Shang Li, Peng Zhang, Ao Li, Jiayu Bao, Zhiqiang Pan, Ying Jie
Penetrating keratoplasty remains the most common treatment to restore vision for corneal diseases. Immune rejection after corneal transplantation is one of the major causes of graft failure. In recent years, Rho-associated protein kinase (ROCK) inhibitors have been found to be associated with the activation of the STATs pathway and are widely studied in autoimmune diseases. Therefore, it may be possible that the ROCK inhibitors also participate in the local and systemic immune regulation in corneal transplantation through activation of the STATs pathway and affect the CD4+ T cell differentiation...
March 11, 2024: Experimental Eye Research
https://read.qxmd.com/read/38478104/predominance-of-t-bet-positive-th1-cells-in-infiltrating-t-lymphocytes-in-most-of-active-arteritis-lesions-of-giant-cell-arteritis
#35
JOURNAL ARTICLE
Hidetoshi Satomi, Mikiko Kobayashi, Ichiro Ito, Koji Asano, Mutsuki Makino, Kenji Kawaguchi, Hiroyuki Kanno
Immunological mechanisms through the activation of CD4-positive T-cells have been assumed to be involved in the pathogenesis of giant cell arteritis (GCA). Many studies employing frozen tissues of temporal artery biopsy, peripheral blood lymphocytes, and plasma of GCA patients have revealed the contribution of interferon-γ and interleukin-17 in both protein and mRNA levels. However, the analyses using formalin-fixed and paraffin-embedded (FFPE) tissue specimens, in which the correlation between histopathologic pictures and immunological circumstances would be elucidated, have been limited...
March 13, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38477949/regulatory-effects-of-long-non-coding-rnas-on-th17-treg-differentiation-and-imbalance
#36
JOURNAL ARTICLE
Reza Dabbaghipour, Elham Ahmadi, Mona Entezam, Omid Rahbar Farzam, Amir Baghbanzadeh, Ali Saber Sichani, Nazila Jalilzadeh, Mahdi Jafarlou, Behzad Baradaran
Scientific research over the past decades has proven the pivotal role of long non-coding RNAs (LncRNAs) in regulating gene expression. The immune responses are controlled through the interaction of pro-inflammatory (predominance of T helper 17 cells (Th17)) and anti-inflammatory cytokines excretion (predominance of Regulatory T cells (Treg)). Recent studies have marked the impact of many diverse LncRNAs on Treg/Th17 imbalances. Moreover, some of the roots and causes of human diseases can be associated with the alterations in the Th17/Treg ratio...
December 28, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38477663/berberine-a-natural-modulator-of-immune-cells-in-multiple-sclerosis
#37
REVIEW
Esmaeil Yazdanpanah, Sepehr Dadfar, Alireza Shadab, Niloufar Orooji, MohammadHossein Nemati, Alireza Pazoki, Seyed-Alireza Esmaeili, Rasoul Baharlou, Dariush Haghmorad
Berberine is a benzylisoquinoline alkaloid found in such plants as Berberis vulgaris, Berberis aristata, and others, revealing a variety of pharmacological properties as a result of interacting with different cellular and molecular targets. Recent studies have shown the immunomodulatory effects of Berberine which result from its impacts on immune cells and immune response mediators such as diverse T lymphocyte subsets, dendritic cells (DCs), and different inflammatory cytokines. Multiple sclerosis (MS) is a chronic disabling and neurodegenerative disease of the central nervous system (CNS) characterized by the recruitment of autoreactive T cells into the CNS causing demyelination, axonal damage, and oligodendrocyte loss...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38473934/osteoimmunology-the-crosstalk-between-t-cells-b-cells-and-osteoclasts-in-rheumatoid-arthritis
#38
REVIEW
Mei Yang, Lei Zhu
Rheumatoid arthritis (RA) is an ongoing inflammatory condition that affects the joints and can lead to severe damage to cartilage and bones, resulting in significant disability. This condition occurs when the immune system becomes overactive, causing osteoclasts, cells responsible for breaking down bone, to become more active than necessary, leading to bone breakdown. RA disrupts the equilibrium between osteoclasts and osteoblasts, resulting in serious complications such as localized bone erosion, weakened bones surrounding the joints, and even widespread osteoporosis...
February 26, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38463658/unremitting-pro-inflammatory-t-cell-phenotypes-and%C3%A2-macrophage-activity-following-paediatric-burn-injury
#39
JOURNAL ARTICLE
Donna Langley, Kate Zimmermann, Emma Krenske, Giorgio Stefanutti, Roy M Kimble, Andrew Ja Holland, Mark W Fear, Fiona M Wood, Tony Kenna, Leila Cuttle
OBJECTIVES: The aim of this study was to characterise the dynamic immune profile of paediatric burn patients for up to 18 months post-burn. METHODS: Flow cytometry was used to measure 25 cell markers, chemokines and cytokines which reflected both pro-inflammatory and anti-inflammatory immune profiles. Peripheral blood mononuclear cells from 6 paediatric burn patients who had returned for repeated burn and scar treatments for > 4 timepoints within 12 months post-burn were compared to four age-matched healthy controls...
2024: Clinical & Translational Immunology
https://read.qxmd.com/read/38463297/efficacy-and-mechanism-of-the-action-of-live-and-heat-killed-bacillus-coagulans-bc198-as-potential-probiotic-in-ameliorating-dextran-sulfate-sodium-induced-colitis-in-mice
#40
JOURNAL ARTICLE
Yen-Chun Koh, Ya-Chu Chang, Wei-Sheng Lin, Siu-Yi Leung, Wei-Jen Chen, Shiuan-Huei Wu, Yu-Shan Wei, Chiau-Ling Gung, Ya-Chun Chou, Min-Hsiung Pan
Inflammatory bowel disease alters the gut microbiota, causes defects in mucosal barrier function, and leads to dysregulation of the immune response to microbial stimulation. This study investigated and compared the efficacy of a candidate probiotic strain, Bacillus coagulans BC198, and its heat-killed form in treating dextran sulfate sodium-induced colitis. Both live and heat-killed B. coagulans BC198 increased gut barrier-associated protein expression, reduced neutrophil and M1 macrophage infiltration of colon tissue, and corrected gut microbial dysbiosis induced by colitis...
March 5, 2024: ACS Omega
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