keyword
MENU ▼
Read by QxMD icon Read
search

th17 treg

keyword
https://www.readbyqxmd.com/read/29141242/chloroquine-autophagic-inhibition-rebalances-th17-treg-mediated-immunity-and-ameliorates-systemic-lupus-erythematosus
#1
Ning An, Yanwen Chen, Chao Wang, Chen Yang, Zhi-Hong Wu, Jing Xue, Lin Ye, Shujun Wang, Hua-Feng Liu, Qingjun Pan
BACKGROUND: Imbalanced cellular immunity is critical to the pathogenesis of systemic lupus erythematosus (SLE). Recently, autophagy has emerged as a key homeostatic mechanism in T lymphocytes. This study was conducted to explore the impact of autophagy on the Th17/ regulatory T (Treg) immune imbalance in SLE. METHODS: Peripheral Th17 and Treg cells from newly diagnosed patients with SLE and healthy controls were detected by flow cytometry. Additionally, the effects of chloroquine (CQ) autophagic inhibition on the Th17/Treg immune response were investigated in vitro...
November 14, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29135515/association-between-allergic-and-nonallergic-rhinitis-and-obstructive-sleep-apnea
#2
Ming Zheng, Xiangdong Wang, Luo Zhang
PURPOSE OF REVIEW: Allergic rhinitis and nonallergic rhinitis (NAR) are common disorders, which have been considered as potential risk factors for obstructive sleep apnea (OSA). This review summarizes the proposed underlying pathophysiological mechanisms to provide a better understanding of the relationship between these conditions. RECENT FINDINGS: In adults, allergic rhinitis and NAR may be considered as symptoms potentiating, rather than risk potentiating factors in the pathophysiology of OSA, whereas in children, these are considered to be independent predictors for sleep-disordered breathing (SDB) and failure of adeno-tonsillectomy, the recommended first-line therapy for children with OSA...
November 14, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29129697/dual-mechanisms-for-balancing-th17-and-treg-cell-fate-by-creb
#3
Antony Symons, Wenjun Ouyang
Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells (Treg), expressing the Foxp3 transcription factor, have a suppressive function and can dampen an immune response. The appropriate balance of these distinct effector functions is critical for an effective immune response and autoimmunity can arise if this process goes awry...
November 9, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29126851/ccr6-signaling-inhibits-suppressor-function-of-induced-treg-during-gut-inflammation
#4
Neeraja Kulkarni, Heikrujam Thoihen Meitei, Sandip Ashok Sonar, Praveen Kumar Sharma, Vikkarasan Rehman Mujeeb, Sharad Srivastava, Ramanamurthy Boppana, Girdhari Lal
CCR6 is a G protein-coupled receptor (GPCR) that binds to a specific chemokine, CCL20. The role of CCR6-CCL20 is very well studied in the migration of immune cells, but the non-chemotaxis functions of CCR6 signaling were not known. Here, we show that during gut inflammation, the frequency of Foxp3(+)CD4(+) T cells (Tregs) reduced in the secondary lymphoid tissues and CCR6(+) Tregs enhanced the expression of RORγt. The peripheral blood mononuclear cells (PBMCs) of ulcerative colitis (UC) patients showed lower percentages of Foxp3(+)CD4(+) T cells, as compared to healthy individuals, with CCR6(+) Tregs showing higher RORγt expression as compared to CCR6(-)Tregs...
November 7, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29123956/mutations-in-jak2-and-calreticulin-genes-are-associated-with-specific-alterations-of-the-immune-system-in-myelofibrosis
#5
Marco Romano, Daria Sollazzo, Sara Trabanelli, Martina Barone, Nicola Polverelli, Margherita Perricone, Dorian Forte, Simona Luatti, Michele Cavo, Nicola Vianelli, Camilla Jandus, Francesca Palandri, Lucia Catani
Myelofibrosis (MF) is a clonal neoplasia associated with chronic inflammation due to aberrant cytokine production. Mutations in Janus Kinase-2 (JAK2), calreticulin (CALR) and myeloproliferative leukemia protein (MPL) genes have been recently associated to MF and they all activate the JAK/STAT signaling pathway. Since this pathway is essential in shaping the immune response, we investigated the role of circulating immune subsets and cytokines in 38 patients (20 carrying JAK2((V617F)),13 exon-9 CALR mutation and 5 triple negative)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29123203/respiratory-syncytial-virus-exacerbates-ova-mediated-asthma-in-mice-through-c5a-c5ar-regulating-cd4-t-cells-immune-responses
#6
Xinyue Hu, Xiaozhao Li, Chengping Hu, Ling Qin, Ruoxi He, Lisha Luo, Wei Tang, Juntao Feng
Asthma exacerbation could be induced by respiratory syncytial virus (RSV), and the underlying pathogenic mechanism is related to complement activation. Although complement might regulate CD4(+)T cells immune responses in asthma model, this regulation existed in RSV-induced asthma model remains incompletely characterrized. In this study, we assessed the contribution of C5a-C5aR to CD4(+)T cell immune responses in RSV-infected asthma mice. Female BALB/C mice were sensitized and challenged with ovalbumin (OVA) while treated with RSV infection and C5a receptor antagonist (C5aRA) during challenge period...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121519/iguratimod-ameliorates-inflammatory-responses-by-modulating-the-th17-treg-paradigm-in-dextran-sulphate-sodium-induced-murine-colitis
#7
Xue-Pei Jiang, Xie-Lin Huang, Zao-Peng Yang, Shun-Cai Wang, Wei Xie, Lei Miao, Li Tang, Zhi-Ming Huang
Inflammatory bowel disease (IBD) is an autoimmune disease with an abnormal and persistent immune response. Iguratimod, a novel anti-rheumatic drug, exhibits anti-inflammatory effects and regulates immune response. The role of iguratimod in intestinal mucosal inflammation and immunity has not been examined. The aim of this study was to investigate whether iguratimod ameliorates dextran sulphate sodium (DSS)-induced murine colitis and its potential regulatory mechanism. Murine colitis was induced by administering 2...
November 6, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29120881/atp-and-t-cell-mediated-rejection
#8
Eduardo Castillo-Leon, Sergio Dellepiane, Paolo Fiorina
PURPOSE OF REVIEW: Purine nucleosides and nucleotides are released in the extracellular space following cell injury and act as paracrine mediators through a number of dedicated membrane receptors. In particular, extracellular ATP (eATP) significantly influences T-lymphocyte activation and phenotype. The purpose of this review is to discuss the role of ATP signaling in the T-cell-mediated alloimmune response. RECENT FINDINGS: In various animal models of solid transplantation, the purinergic axis has been targeted to prevent acute rejection and to promote long-term graft tolerance...
November 7, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29120583/role-of-lymphocyte-subpopulations-in-the-immunopathogenesis-of-psoriasis-and-the-effect-of-narrow-band-uvb-phototherapy-on-the-immunological-profile-of-psoriasis-patients
#9
Mona Fattouh, Asmaa N El-Din, Mohammed A El-Hamd
Psoriasis is one of the most common chronic, inflammatory, T-cell-mediated autoimmune diseases. Narrow-band UVB (NB-UVB) therapy is widely used in the treatment of psoriasis; however, its mechanism of action is still not well understood. The objective of this study was to investigate the circulating T-lymphocyte subpopulations in psoriasis patients before and after NB-UVB, to get insights into the mechanism of NB-UVB in the treatment of psoriasis. The severity of psoriasis was assessed by means of the Psoriasis Area and Severity Index (PASI-score)...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29119640/il-23-actived-%C3%AE-%C3%AE-t-cells-affect-th17-cells-and-regulatory-t-cells-by-secreting-il-21-in-children-with-primary-nephrotic-syndrome
#10
Li Zhang, Junli Yan, Baohui Yang, Gaofu Zhang, Mo Wang, Shifang Dong, Wei Liu, Haiping Yang, Qiu Li
OBJECTIVE: This study (1) analyzed the percentage of γδ T cells, γδ T cell subsets, Th17 cells, and regulatory T cells (Treg cells), and (2) determined the role of IL-23 in primary nephrotic syndrome (PNS) patients with active disease and in remission. MATERIALS AND METHODS: Eighty-four PNS patients and 51 healthy age-matched controls were included in this study. The percentage of γδ T cells, γδ T cell subsets, Th17 cells, and Treg cells in peripheral blood mononuclear cells (PBMCs) were analyzed by fluorescence-activated cell sorting...
November 9, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29112187/number-of-circulating-non-classical-cd14-cd16-monocytes-negatively-correlates-with-das28-and-swollen-joints-count-in-peripheral-spondyloarthritis-patients
#11
Zofia Guła, Małgorzata Stec, Magdalena Rutkowska-Zapała, Marzena Lenart, Mariusz Korkosz, Jerzy Gąsowski, Jarosław Baran, Monika Baj-Krzyworzeka, Rafał Szatanek, Jarosław Czyż, Maciej Siedlar
INTRODUCTION    Different clinical course and pattern of skeletal involvement in peripheral (per) and axial (ax) spondyloarthritis (SpA) suggests distinct pathophysiology of these two phenotypic manifestations of SpA. Monocytes, as a part of innate immune system, seem to play an important role in the pathogenesis of SpA, but exact inflammatory pathways remain to be elucidated. Regulatory T lymphocytes (Treg) and Th17 lymphocytes are also known to influence pro- and anti-inflammatory reactions. OBJECTIVES    The aim of our study was to compare absolute numbers of monocyte subpopulations, Treg and Th17 lymphocytes with clinical measures of disease activity in perSpA and axSpA...
November 7, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29106735/human-periodontal-ligament-fibroblasts-synthesize-c-reactive-protein-and-th-related-cytokines-in-response-to-interleukin-il-6-trans-signaling
#12
A Hernández-Caldera, R Vernal, R Paredes, P Veloso-Matta, J Astorga, M Hernández
AIM: To characterize the potential of human periodontal ligament fibroblasts (HPLF) to synthesize CRP and Th-related cytokines in response to IL-6 in periodontal health and apical inflammation. METHODOLOGY: Primary HPLF stimulated with IL-6, soluble(s) IL-6 receptor (R) and controls were assayed for CRP, Th1, Th2, Th17 and Treg-related cytokines by quantitative real time PCR and ELISA, respectively. IL-6R mRNA expression and its soluble protein levels were screened in HPLF cultures, and ex vivo samples of healthy periodontal ligaments (n=5) and apical lesions (n=13)...
November 6, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/29105622/the-effects-of-t-helper-17-and-regulatory-t-cells-on-patients-with-carotid-atherosclerosis
#13
Bo Wang, Xiaopeng Wang, Huifang Sun, Lili Hu, Jianbo Gao
This study was aimed to observe the level of T helper 17 (Th17) cells and CD4(+) CD25(+) Foxp(3+) regulatory T cells (Tregs) and their related factors in carotid atherosclerosis (AS) patients and AS model rats to explore the influence of Th17 on the pathological process of AS and its specific mechanism. 60 cases with AS in our hospital from July 2012 to July 2014 were recruited for this study as the observation group, and 40 healthy people who came to the hospital for a physical examination were the control group...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29104468/extensively-disturbance-of-regulatory-t-cells-th17-cells-balance-in-stage-ii-pulmonary-sarcoidosis
#14
Jingjing Ding, Jinghong Dai, Hourong Cai, Qian Gao, Yanting Wen
BACKGROUND: Sarcoidosis is a systemic inflammatory disorder characterized by granulomas. Not enough evidences correlate the derangement of CD4+ T subsets, which have an impact on the therapeutic effects of corticosteroids, with the radiographical staging of sarcoidosis. Here we show the disturbance of CD4+ T subsets in newly diagnosed stage II pulmonary sarcoidosis, which is the most common stage in which corticosteroids treatment is used. MATERIALS AND METHODS: 39 newly diagnosed and treatment-naïve patients and 9 subjects after corticosteroids treatment were included...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29099629/regulatory-t-cells-improve-pregnancy-rate-in-rif-patients-after-additional-ivig-treatment
#15
Majid Ahmadi, Samaneh Abdolmohammadi-Vahid, Mahnaz Ghaebi, Leili Aghebati-Maleki, Sanam Dolati, Laya Farzadi, Aliyeh Ghasemzadeh, Kobra Hamdi, Vahid Younesi, Mohammad Nouri, Mehdi Yousefi
RIF (repeated implantation failure) women with immunologic basis and cellular abnormalities may benefit from intravenous immunoglobulins (IVIG) as an immunomodulator based on different studies. In this study, we evaluated the effect of IVIG on the frequency and function of Th17 and Treg cells, as two important subgroups of CD4(+) T cells in implantation and pregnancy rates. Seventy-two RIF patients with preconception Th1⁄Th2 ratio and natural killer (NK) cells frequency and activity elevation were selected and divided into two groups; 40 out of 72 received IVIG, aspirin, and heparin (anoxaparin) and constituted the treatment group and 32 patients received aspirin and heparin (anoxaparin) and no IVIG and were the control group...
November 3, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29097999/clostridium-butyricum-cgmcc0313-1-protects-against-autoimmune-diabetes-by-modulating-intestinal-immune-homeostasis-and-inducing-pancreatic-regulatory-t-cells
#16
Lingling Jia, Kai Shan, Li-Long Pan, Ninghan Feng, Zhuwu Lv, Yajun Sun, Jiahong Li, Chengfei Wu, Hao Zhang, Wei Chen, Julien Diana, Jia Sun, Yong Q Chen
Recent evidence indicates that indigenous Clostridium species induce colonic regulatory T cells (Tregs), and gut lymphocytes are able to migrate to pancreatic islets in an inflammatory environment. Thus, we speculate that supplementation with the well-characterized probiotics Clostridium butyricum CGMCC0313.1 (CB0313.1) may induce pancreatic Tregs and consequently inhibit the diabetes incidence in non-obese diabetic (NOD) mice. CB0313.1 was administered daily to female NOD mice from 3 to 45 weeks of age. The control group received an equal volume of sterile water...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29096750/clinical-efficacy-and-mechanism-of-lymphoplasma-exchange-in-the-treatment-of-guillain-barre-syndrome
#17
M-C Luo, W-F Wang, W-F Yin, Y Li, B-J Li, W-W Duan, Q-M Zeng, Y-B Luo, X-S Yang, H Yang
Guillain-Barre syndrome (GBS) is an autoimmune disease of the nervous system and is the most common acute polyneuropathy. Both cellular and humoral immunity are believed to be involved in the pathogenesis of GBS, and various types of activated CD4+ T cells are thought to orchestrate the onset and progression of GBS. Lymphoplasma exchange (LPE) filtering out activated lymphocytes while exchanging plasma has been used for GBS treatment for years. However the treatment is still not yet optimal. In order to assess the efficacy of this treatment, we evaluate the effect of LPE and determine the appropriate frequency of LPE treatments for GBS patients through comparing the neurological deficit scores and the changes in related immunology indicators of GBS patients before and after LPE treatment...
October 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29096404/cyclopia-extracts-enhance-th1-th2-and-th17-type-t-cell-responses-and-induce-foxp3-cells-in-murine-cell-culture
#18
Shiho Murakami, Yutaka Miura, Makoto Hattori, Hiroshi Matsuda, Christiaan J Malherbe, Christo J F Muller, Elizabeth Joubert, Tadashi Yoshida
Cyclopia genistoides, one of the traditional South African medicinal plants, and other species of the same genus offer noteworthy phenolic profiles, in particular high levels of the anti-allergic xanthone mangiferin. Hot water and 40% ethanol-water (v/v) extracts, prepared from C. genistoides, Cyclopia subternata, and Cyclopia maculata, were tested for immune-regulating activity in vitro using murine splenocytes and mesenteric lymph node cells. The 40% ethanol-water extracts of C. genistoides and C. subternata significantly enhanced production of several types of cytokines, including IL-4, IL-17, and IFN-γ, by antigen-stimulated splenocytes...
November 2, 2017: Planta Medica
https://www.readbyqxmd.com/read/29090089/sirtinol-regulates-the-balance-of-th17-treg-to-prevent-allograft-rejection
#19
Qing Ye, Mingjian Zhang, Yang Wang, Shangxi Fu, Shu Han, Liming Wang, Quanxing Wang
BACKGROUND: Current immunosuppressive medications used after transplantation induce significant toxicity , and a new medication regimen is needed. Based on recent research, Sirt1 exerts a proinflammatory effect on the immune response. Sirtinol is a Sirt1 inhibitor, but its impact on allograft rejection and its molecular mechanisms of action have not yet been reported. RESLUTS: In this study, we examined the effect of sirtinol on prolonging allograft survival in a mouse cervical heterotopic heart transplantation model...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29079322/increased-frequencies-of-th17-cells-and-il17a-producing-regulatory-t-cells-preceding-the-immunodiscordant-response-to-antiretroviral-treatment
#20
Isaac Rosado-Sánchez, I Herrero-Fernández, Laura Tarancon-Diez, Santiago Moreno, Jose Antonio Iribarren, David Dalmau, Francisco Vera-Méndez, M Leal, Y M Pacheco
BACKGROUND: Despite the fact that antiretroviral therapy (cART) suppresses HIV-viremia, an adequate CD4 T-cell recovery is not always achieved (immunodiscordant response to cART). IL17a-producing CD4 T-cells (Th17) constitutes an important subset involved in the preservation of mucosal surfaces integrity, which depletion has been associated with disease progression in HIV-infection. However, whether Th17 frequency at cART initiation is associated with a poor CD4 T-cell recovery has not been yet explored...
October 25, 2017: Journal of Infection
keyword
keyword
46911
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"