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https://www.readbyqxmd.com/read/29166608/s-nitrosylation-of-pink1-attenuates-pink1-parkin-dependent-mitophagy-in-hipsc-based-parkinson-s-disease-models
#1
Chang-Ki Oh, Abdullah Sultan, Joseph Platzer, Nima Dolatabadi, Frank Soldner, Daniel B McClatchy, Jolene K Diedrich, John R Yates, Rajesh Ambasudhan, Tomohiro Nakamura, Rudolf Jaenisch, Stuart A Lipton
Mutations in PARK6 (PINK1) and PARK2 (Parkin) are linked to rare familial cases of Parkinson's disease (PD). Mutations in these genes result in pathological dysregulation of mitophagy, contributing to neurodegeneration. Here, we report that environmental factors causing a specific posttranslational modification on PINK1 can mimic these genetic mutations. We describe a molecular mechanism for impairment of mitophagy via formation of S-nitrosylated PINK1 (SNO-PINK1). Mitochondrial insults simulating age- or environmental-related stress lead to increased SNO-PINK1, inhibiting its kinase activity...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166564/optical-control-of-dopamine-receptors-using-a-photoswitchable-tethered-inverse-agonist
#2
Prashant Donthamsetti, Nils Winter, Matthias Schönberger, Joshua Levitz, Cherise Stanley, Jonathan A Javitch, Ehud Y Isacoff, Dirk Trauner
Family A G protein-coupled receptors (GPCRs) control diverse biological processes and are of great clinical relevance. Their archetype rhodopsin becomes naturally light sensitive by binding covalently to the photoswitchable tethered ligand (PTL) retinal. Other GPCRs, however, neither bind covalently to ligands nor are light sensitive. We sought to impart the logic of rhodopsin to light-insensitive Family A GPCRs in order to enable their remote control in a receptor-specific, cell-type-specific and spatio-temporally precise manner...
November 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29166468/lafora-and-tr%C3%A3-tiakoff-the-naming-of-the-inclusion-bodies-discovered-by-lewy
#3
Eliasz Engelhardt
Fritz Heinrich Jakob Lewy described, for the first time, in 1912, novel peculiar inclusions in neurons of certain brain nuclei in patients with Paralysis agitans, and compared his finding to the amyloid bodies described by Lafora one year before. Gonzalo Rodriguez Lafora studied one patient with Paralysis agitans, in 1913, and recognized, described, and depicted structures identical to those previously reported by Lewy. He was the first to acknowledge Lewy's finding, and also the first to name such inclusions after the discoverer - cuerpos intracelulares de Lewy (Lewy bodies)...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29165839/striatal-dopamine-in-parkinson-s-disease-a-meta-analysis-of-imaging-studies
#4
REVIEW
Valtteri Kaasinen, Tero Vahlberg
A meta-analysis of 141 PET and SPECT studies that have investigated striatal presynaptic dopamine function in Parkinson's disease (PD) was performed. Subregional estimates of striatal dopamine metabolism are presented. The aromatic L-amino-acid decarboxylase (AADC) defect appears to be consistently smaller than the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) defects, suggesting up-regulation of AADC function in PD. The correlation between disease severity and dopamine loss appears linear but the majority of longitudinal studies point to a negative exponential progression pattern of dopamine loss in PD...
November 22, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29165837/pulse-duration-settings-in-subthalamic-stimulation-for-parkinson-s-disease
#5
Frank Steigerwald, Lars Timmermann, Andrea Kühn, Alfons Schnitzler, Martin M Reich, Anna Dalal Kirsch, Michael Thomas Barbe, Veerle Visser-Vandewalle, Julius Hübl, Christoph van Riesen, Stefan Jun Groiss, Alexia-Sabine Moldovan, Sherry Lin, Stephen Carcieri, Ljubomir Manola, Jens Volkmann
BACKGROUND: Stimulation parameters in deep brain stimulation (DBS) of the subthalamic nucleus for Parkinson's disease (PD) are rarely tested in double-blind conditions. Evidence-based recommendations on optimal stimulator settings are needed. Results from the CUSTOM-DBS study are reported, comparing 2 pulse durations. METHODS: A total of 15 patients were programmed using a pulse width of 30 µs (test) or 60 µs (control). Efficacy and side-effect thresholds and unified PD rating scale (UPDRS) III were measured in meds-off (primary outcome)...
November 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29165825/understanding-the-lived-experiences-of-parkinson-s-disease-and-deep-brain-stimulation-dbs-through-occupational-changes
#6
Jacki Liddle, Jessie Phillips, Louise Gustafsson, Peter Silburn
BACKGROUND: Deep brain stimulation (DBS), a surgically based treatment for people living with Parkinson's disease (PD), can result in a significant improvement of motor symptoms. However, the broader impact of DBS and the changes it creates are not well understood. Greater understanding of the experiences and needs related to DBS would enable development of relevant outcome measures and supports. OBJECTIVES: To explore the lived experiences of people undergoing DBS for Parkinson's disease...
November 22, 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/29165720/-relationship-strain-parkinson-s-disease-gender-specific-distress-of-partners-of-patients-with-parkinson-s-disease
#7
Christoph Braukhaus, Uwe Jahnke, Tanja Zimmermann
A Parkinson's disease is attended by high strain for the patients and an obvious loss of relationship functioning. Partners of patients (N=110) were evaluated via self-assessment in terms of own depression (PHQ-9), own fear of progression (PA-F-P-KF), relationship quality (PFB) as well as perceived deficits in everyday life and nonverbal communication. 26% of women and 11% of men showed depression scores, 51% of women and 41% of men dysfunctional fear of progression and about 60% were unsatisfied with their relationship...
November 17, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29165426/the-mitochondrial-upr-mechanisms-physiological-functions-and-implications-in-ageing
#8
REVIEW
Tomer Shpilka, Cole M Haynes
Mitochondrial function declines during ageing owing to the accumulation of deleterious mitochondrial genomes and damage resulting from the localized generation of reactive oxygen species, both of which are often exacerbated in diseases such as Parkinson disease. Cells have several mechanisms to assess mitochondrial function and activate a transcriptional response known as the mitochondrial unfolded protein response (UPR(mt)) when mitochondrial integrity and function are impaired. The UPR(mt) promotes cell survival and the recovery of the mitochondrial network to ensure optimal cellular function...
November 22, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29165011/motor-imagery-of-walking-and-walking-while-talking-a-pilot-randomized-controlled-trial-protocol-for-older-adults
#9
Helena M Blumen, Joe Verghese
Over a third of community-residing elderly have clinical gait abnormalities, and gait impairment is associated with morbidity, mortality and dementia. Motor imagery - envisioning motor actions without actual execution - has been used to improve gait in Parkinson's disease and poststroke, but the efficacy of motor imagery in healthy elderly is unknown. This single-blind pilot randomized-controlled trial aims to establish feasibility and explore the efficacy of a 3-month, telephone-based motor imagery intervention - that involves imagined walking, imagined talking and imagined walking while talking for improving gait in 48 healthy elderly...
November 22, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29164735/substituting-the-target-after-unsatisfactory-outcome-of-deep-brain-stimulation-in-advanced-parkinson-s-disease-cases-from-the-nstaps-trial-and-systematic-review-of-the-literature
#10
Timo R Ten Brinke, Vincent J J Odekerken, Teus van Laar, J Marc C van Dijk, Joke M Dijk, Pepijn van den Munckhof, P Rick Schuurman, Rob M A de Bie
BACKGROUND: Deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) and the subthalamic nucleus (STN) are established treatment option in Parkinson's disease (PD). If DBS does not provide the desired effect, re-operation to the alternative target is a treatment option, but data on the effect of re-operation are scarce. OBJECTIVES: The objective of this study is to evaluate the clinical effect of re-operation the alternative target after failure of initial STN or GPi DBS for Parkinson's disease...
November 22, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29164724/intraoperative-localization-of-the-subthalamic-nucleus-using-long-latency-somatosensory-evoked-potentials
#11
Carlos Trenado, Saskia Elben, Lena Friggemann, Stefan Jun Groiss, Jan Vesper, Alfons Schnitzler, Lars Wojtecki
BACKGROUND: Target localization for deep brain stimulation (DBS) is a challenging step that determines not only the correct placement of stimulation electrodes, but also influences the success of the DBS procedure as reflected in the desired clinical outcome of a patient. OBJECTIVE: We report on the feasibility of DBS target localization in the subthalamic nucleus (STN) by long-latency somatosensory evoked potentials (LL-SSEPs) (>40 msec) in Parkinson's disease (PD) patients...
November 22, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29164519/atorvastatin-prevents-early-oxidative-events-and-modulates-inflammatory-mediators-in-the-striatum-following-intranasal-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-mptp-administration-in-rats
#12
Naiani F Marques, Adalberto A Castro, Gianni Mancini, Fernanda L Rocha, Adair R S Santos, Rui D Prediger, Andreza Fabro De Bem, Carla I Tasca
Atorvastatin is a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor with cholesterol-lowering, anti-inflammatory, and antioxidant properties. Increasing evidence show atorvastatin acts as a protective agent against insults in the central nervous system (CNS). The regular use of statins has been associated with a reduced risk of Parkinson's disease (PD) development. Here, we evaluated early events involved in the neurotoxicity induced by intranasal (i.n.) infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in rats and the potential of atorvastatin to prevent these early toxic events...
November 21, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29164496/correction-to-opicapone-a-review-in-parkinson-s-disease
#13
Lesley J Scott
Parkinson's disease (PD) is the most common chronic, progressive, neurodegenerative disease, with a mean age of onset of 57 years [1, 2].
November 21, 2017: Drugs
https://www.readbyqxmd.com/read/29164380/correlation-between-the-availability-of-dopamine-transporter-and-olfactory-function-in-healthy-subjects
#14
Kyoungjune Pak, Keunyoung Kim, Myung Jun Lee, Jae Meen Lee, Bum Soo Kim, Seong-Jang Kim, In Joo Kim
OBJECTIVES: Olfactory dysfunction in Parkinson's disease is usually prodromal to other symptoms. In this study, we aimed to explore the association of olfactory function with the availabilities of striatal dopamine transporter (DAT) in healthy subjects. METHODS: Data used in the preparation of this article were obtained from Parkinson's Progression Markers Initiative database ( www.ppmi-info.org/data ). The study population consisted of healthy controls with screening (123)I-FP-CIT single photon emission tomography (SPECT)...
November 21, 2017: European Radiology
https://www.readbyqxmd.com/read/29164312/efficacy-and-safety-of-rotigotine-in-elderly-patients-with-parkinson-s-disease-in-comparison-with-the-non-elderly-a-post-hoc-analysis-of-randomized-double-blind-placebo-controlled-trials
#15
Masahiro Nomoto, Hirotaka Iwaki, Hiroyuki Kondo, Masaya Sakurai
Rotigotine-a non-ergot dopamine agonist-has two advantages; it can stimulate all dopamine receptors (D1-D5) like innate dopamine, and its transdermal administration provides continuous dopaminergic stimulation. The age of the patient impacts the effect and adverse events of anti-parkinsonian treatment. We conducted a post hoc analysis on three randomized, double-blind, placebo-controlled trials performed in Japan to clarify the difference of anti-parkinsonian treatment in elderly and non-elderly patients. Data from two combination therapy trials (with levodopa) in advanced stage Parkinson's disease patients and one monotherapy trial in early stage patients were pooled and grouped by age (non-elderly aged < 70, elderly aged 70 +)...
November 21, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29163340/the-dominant-subthalamic-nucleus-phenomenon-in-bilateral-deep-brain-stimulation-for-parkinson-s-disease-evidence-from-a-gait-analysis-study
#16
Mario Giorgio Rizzone, Maurizio Ferrarin, Michele Maria Lanotte, Leonardo Lopiano, Ilaria Carpinella
Background: It has been suggested that parkinsonian [Parkinson's disease (PD)] patients might have a "dominant" (DOM) subthalamic nucleus (STN), whose unilateral electrical stimulation [deep brain stimulation (DBS)] could lead to an improvement in PD symptoms similar to bilateral STN-DBS. Objectives: Since disability in PD patients is often related to gait problems, in this study, we wanted to investigate in a group of patients bilaterally implanted for STN-DBS: (1) if it was possible to identify a subgroup of subjects with a dominant STN; (2) in the case, if the unilateral stimulation of the dominant STN was capable to improve gait abnormalities, as assessed by instrumented multifactorial gait analysis, similarly to what observed with bilateral stimulation...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29163333/mutation-analysis-of-consanguineous-moroccan-patients-with-parkinson-s-disease-combining-microarray-and-gene-panel
#17
Ahmed Bouhouche, Christelle Tesson, Wafaa Regragui, Mounia Rahmani, Valérie Drouet, Houyam Tibar, Zouhayr Souirti, Rafiqua Ben El Haj, Naima Bouslam, Mohamed Yahyaoui, Alexis Brice, Ali Benomar, Suzanne Lesage
During the last two decades, 15 different genes have been reported to be responsible for the monogenic form of Parkinson's disease (PD), representing a worldwide frequency of 5-10%. Among them, 10 genes have been associated with autosomal recessive PD, with PRKN and PINK1 being the most frequent. In a cohort of 145 unrelated Moroccan PD patients enrolled since 2013, 19 patients were born from a consanguineous marriage, of which 15 were isolated cases and 4 familial. One patient was homozygous for the common LRRK2 G2019S mutation and the 18 others who did not carry this mutation were screened for exon rearrangements in the PRKN gene using Affymetrix Cytoscan HD microarray...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29163328/parkinson-s-disease-severity-at-3%C3%A2-years-can-be-predicted-from-non-motor-symptoms-at-baseline
#18
Alba Ayala, José Matías Triviño-Juárez, Maria João Forjaz, Carmen Rodríguez-Blázquez, José-Manuel Rojo-Abuin, Pablo Martínez-Martín
Objective: The aim of this study is to present a predictive model of Parkinson's disease (PD) global severity, measured with the Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD). Methods: This is an observational, longitudinal study with annual follow-up assessments over 3 years (four time points). A multilevel analysis and multiple imputation techniques were performed to generate a predictive model that estimates changes in the CISI-PD at 1, 2, and 3 years...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29163234/a-comparison-of-treatment-seeking-behavioral-addiction-patients-with-and-without-parkinson-s-disease
#19
Anne Sauvaget, Susana Jiménez-Murcia, Fernando Fernández-Aranda, Roser Granero, Marie Grall-Bronnec, Caroline Victorri-Vigneau, Samuel Bulteau, Pascal Derkinderen, Jean M Vanelle, Anders Hakansson, Gemma Mestre-Bach, Trevor Steward, José M Menchón
The administration of dopaminergic medication to treat the symptoms of Parkinson's disease (PD) is associated with addictive behaviors and impulse control disorders. Little is known, however, on how PD patients differ from other patients seeking treatments for behavioral addictions. The aim of this study was to compare the characteristics of behavioral addiction patients with and without PD. N = 2,460 treatment-seeking men diagnosed with a behavioral addiction were recruited from a university hospital. Sociodemographic, impulsivity [Barratt Impulsiveness Scale (BIS-11)], and personality [Temperament and Character Inventory-Revised (TCI-R)] measures were taken upon admission to outpatient treatment...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29163226/adenosine-a2a-receptor-modulates-the-activity-of-globus-pallidus-neurons-in-rats
#20
Hui-Ling Diao, Yan Xue, Xiao-Hua Han, Shuang-Yan Wang, Cui Liu, Wen-Fang Chen, Lei Chen
The globus pallidus is a central nucleus in the basal ganglia motor control circuit. Morphological studies have revealed the expression of adenosine A2A receptors in the globus pallidus. To determine the modulation of adenosine A2A receptors on the activity of pallidal neurons in both normal and parkinsonian rats, in vivo electrophysiological and behavioral tests were performed in the present study. The extracellular single unit recordings showed that micro-pressure administration of adenosine A2A receptor agonist, CGS21680, regulated the pallidal firing activity...
2017: Frontiers in Physiology
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