keyword
MENU ▼
Read by QxMD icon Read
search

Hypothalamus inflammation

keyword
https://www.readbyqxmd.com/read/29317289/baroreflex-stimulation-attenuates-central-but-not-peripheral-inflammation-in-conscious-endotoxemic-rats
#1
Fernanda Brognara, Jaci A Castania, Daniel P M Dias, Alexandre H Lopes, Rubens Fazan, Alexandre Kanashiro, Luis Ulloa, Helio C Salgado
We previously reported that activation of the baroreflex, a critical physiological mechanism controlling cardiovascular homeostasis, through electrical stimulation of the aortic depressor nerve attenuates joint inflammation in experimental arthritis. However, it is unknown whether baroreflex activation can control systemic inflammation. Here, we investigate whether baroreflex activation controls systemic inflammation in conscious endotoxemic rats. Animals underwent sham or electrical aortic depressor nerve stimulation initiated 10 min prior to a lipopolysaccharide (LPS) challenge, while inflammatory cytokine levels were measured in the blood, spleen, heart and hypothalamus 90 min after LPS treatment...
January 6, 2018: Brain Research
https://www.readbyqxmd.com/read/29316939/dietary-fats-promote-functional-and-structural-changes-in-the-median-eminence-blood-spinal-fluid-interface-the-protective-role-for-bdnf
#2
Albina F Ramalho, Bruna Bombassaro, Nathalia R Dragano, Carina Solon, Joseane Morari, Milena Fioravante, Roberta Barbizan, Licio A Velloso, Eliana P Araujo
BACKGROUND: The consumption of large amounts of dietary fats activates an inflammatory response in the hypothalamus, damaging key neurons involved in the regulation of caloric intake and energy expenditure. It is currently unknown why the mediobasal hypothalamus is the main target of diet-induced brain inflammation. We hypothesized that dietary fats can damage the median eminence blood/spinal fluid interface. METHODS: Swiss mice were fed on a high-fat diet, and molecular and structural studies were performed employing real-time PCR, immunoblot, immunofluorescence, transmission electron microscopy, and metabolic measurements...
January 9, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29305861/role-of-thyroid-transcription-factor-1-in-transcriptional-regulation-of-heme-oxygenase-1
#3
Bora Jeong, Han Rae Kim, Nan Seong Choi, Byong Seo Park, Hyejin Eom, Jeong Woo Park, Jae Geun Kim, Byung Ju Lee
Here, we report thyroid transcription factor 1 (TTF-1) as an important transcription factor for the expression of heme oxygenase-1 (HO-1). HO-1 is a well-known cytoprotective enzyme against inflammation. We observed that HO-1 co-expressed with TTF-1 in mouse hypothalamic cells. Results from luciferase and chromatin immunoprecipitation assays revealed that TTF-1 directly activated HO-1 transcription by binding to binding domains in the 5'-flanking region of the HO-1 gene. A proinflammatory cytokine, tumor necrosis factor-alpha (TNF-α), induced nuclear translocation of TTF-1 and increased binding affinity of TTF-1 to its binding sites on the HO-1 gene...
January 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29288825/inhibitory-effects-of-aconiti-lateralis-radix-preparata-on-chronic-intermittent-cold-induced-inflammation-in-the-mouse-hypothalamus
#4
Wonnam Kim, Wonil Lee, Jin Gyu Choi, In Gyoung Ju, Yun-Kyung Kim, Tae Hee Lee, Myung Sook Oh
ETHNOPHARMACOLOGICAL RELEVANCE: Aconiti Lateralis Radix Preparata (AR) is the most frequently used herb to generate heat and treat symptoms associated with coldness in Asia. AIMS OF THE STUDY: The hypothalamus is one of the master regulators to maintain constant core body temperature. Chronic exposure to cold stress disturbs homeostatic regulation, gradually resulting in hypothalamic inflammation. This study investigate the effects of AR, on the chronic intermittent cold (CIC)-induced release of pro-inflammatory signaling molecules in the mouse hypothalamus...
December 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29286405/live-images-of-glut4-protein-trafficking-in-mouse-primary-hypothalamic-neurons-using-deconvolution-microscopy
#5
Chun Austin Changou, Reni Ajoy, Szu-Yi Chou
Type 2 diabetes mellitus (T2DM) is a global health crisis which is characterized by insulin signaling impairment and chronic inflammation in peripheral tissues. The hypothalamus in the central nervous system (CNS) is the control center for energy and insulin signal response regulation. Chronic inflammation in peripheral tissues and imbalances of certain chemokines (such as CCL5, TNFα, and IL-6) contribute to diabetes and obesity. However, the functional mechanism(s) connecting chemokines and hypothalamic insulin signal regulation still remain unclear...
December 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29281967/the-effects-of-vitamin-d-administration-on-brain-inflammatory-markers-in-high-fat-diet-induced-obese-rats
#6
Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Ghazaleh Nameni, Ghazaleh Hajiluian, Parviz Shahabi
BACKGROUND: Obesity induced brain inflammation is associated with cognitive disorders. We aimed to investigate the influence of vitamin D on hypothalamus and hippocampus inflammatory response in high-fat diet induced obese rats. METHODS: In the beginning of the study, 40 rats were divided into two groups: control diet and high fat diet (HFD) for 16 weeks; then each group subdivided into two groups including: N, ND + vitamin D, HFD and HFD + vitamin D. Vitamin D supplementation was done for 5 weeks at 500 IU/kg dosage...
December 28, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/29250069/histamine-regulates-the-inflammatory-profile-of-sod1-g93a-microglia-and-the-histaminergic-system-is-dysregulated-in-amyotrophic-lateral-sclerosis
#7
Savina Apolloni, Paola Fabbrizio, Susanna Amadio, Giulia Napoli, Veronica Verdile, Giovanna Morello, Rosario Iemmolo, Eleonora Aronica, Sebastiano Cavallaro, Cinzia Volonté
Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disease where activated glia release pro-inflammatory cytokines that trigger a vicious cycle of neurodegeneration in the absence of resolution of inflammation. Given the well-established role of histamine as a neuron-to-glia alarm signal implicated in brain disorders, the aim of this study was to investigate the expression and regulation of the histaminergic pathway in microglial activation in ALS mouse model and in humans. By examining the contribution of the histaminergic system to ALS, we found that particularly via H1 and H4 receptors, histamine promoted an anti-inflammatory profile in microglia from SOD1-G93A mice by modulating their activation state...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29247675/adrenergic-and-glucocorticoid-receptor-antagonists-reduce-ozone-induced-lung-injury-and-inflammation
#8
Andres R Henriquez, Samantha J Snow, Mette C Schladweiler, Colette N Miller, Janice A Dye, Allen D Ledbetter, Judy E Richards, Kevin Mauge-Lewis, Marie A McGee, Urmila P Kodavanti
Recent studies showed that the circulating stress hormones, epinephrine and corticosterone/cortisol, are involved in mediating ozone-induced pulmonary effects through the activation of the sympathetic-adrenal-medullary (SAM) and hypothalamus-pituitary-adrenal (HPA) axes. Hence, we examined the role of adrenergic and glucocorticoid receptor inhibition in ozone-induced pulmonary injury and inflammation. Male 12-week old Wistar-Kyoto rats were pretreated daily for 7days with propranolol (PROP; a non-selective β adrenergic receptor [AR] antagonist, 10mg/kg, i...
December 13, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29233861/restoration-of-metabolic-inflammation-related-ghrelin-resistance-by-weight-loss
#9
Farhana Naznin, Koji Toshinai, Tm Zaved Waise, Tadashi Okada, Hideyuki Sakoda, Masamitsu Nakazato
High-fat diet (HFD)-induced metabolic inflammation in the central and peripheral organs contributes to the pathogenesis of obesity. Long-term HFD blunts signaling by ghrelin, a gastric-derived orexigenic peptide, in the vagal afferent nerve via a mechanism involving in situ activation of inflammation. This study was undertaken to investigate whether ghrelin resistance is associated with progressive development of metabolic inflammation. In mice, ghrelin's orexigenic activity was abolished 2 to 4 weeks after the commencement of HFD (60% of energy from fat), consistent with the timing of accumulation and activation of macrophages and microglia in the nodose ganglion and hypothalamus...
December 12, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29228949/a-mathematical-model-for-histamine-synthesis-release-and-control-in-varicosities
#10
Janet Best, H F Nijhout, Srimal Samaranayake, Parastoo Hashemi, Michael Reed
BACKGROUND: Histamine (HA), a small molecule that is synthesized from the amino acid histidine, plays an important role in the immune system where it is associated with allergies, inflammation, and T-cell regulation. In the brain, histamine is stored in mast cells and other non-neuronal cells and also acts as a neurotransmitter. The histamine neuron cell bodies are in the tuberomammillary (TM) nucleus of the hypothalamus and these neurons send projections throughout the central nervous system (CNS), in particular to the cerebral cortex, amygdala, basal ganglia, hippocampus, thalamus, retina, and spinal cord...
December 12, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/29193473/autoimmune-glial-fibrillary-acidic-protein-astrocytopathy-in-chinese-patients-a-retrospective-study
#11
Youming Long, Junyan Liang, Huiming Xu, Qingmei Huang, Jie Yang, Cong Gao, Wei Qiu, Shaopeng Lin, Xiaohui Chen
OBJECTIVE: We aimed to describe the clinical, radiological, and pathological features of an autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. METHODS: Data from 19 patients with positive GFAP-IgG in cerebrospinal fluid (CSF) were retrospectively analyzed. RESULTS: The main disease manifestations included myelitis (68.4%), headache (63.2%), abnormal vision (63.2%), fever (52.6%), ataxia (36.8%), psychosis (31.6%), dyskinesia (15...
November 29, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29165613/exposure-to-concentrated-ambient-pm2-5-compromises-spermatogenesis-in-a-mouse-model-role-of-suppression-of-hypothalamus-pituitary-gonads-axis
#12
Lianglin Qiu, Minjie Chen, Xiaoke Wang, Xiaobo Qin, Sufang Chen, Yingyun Qian, Zhenzhen Liu, Qi Cao, Zhekang Ying
Background: Epidemiological studies link ambient fine particulate matter (PM2.5) pollution to abnormalities in the male reproductive system. However, few toxicological studies have investigated this potentially important adverse effect of PM2.5 pollution. Therefore, in the present study, we analyzed the effects of PM2.5 exposure on spermatogenesis and hypothalamic-pituitary- gonadal (HPG) axis in a murine model. Methods: Fourteen male C57BL/6J mice were subjected to a 4-month exposure to filtered air (FA) or concentrated ambient PM2...
November 20, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29160327/imbalance-in-amino-acid-and-purine-metabolisms-at-the-hypothalamus-in-inflammation-associated-depression-by-gc-ms
#13
Yu Wu, Yonghong Li, Yanjuan Jia, Chaojun Wei, Hui Xu, Rui Guo, Yuanting Li, Jing Jia, Xiaoming Qi, Xiaoling Gao
Hypothalamic dysfunction is a key factor in depression; increasing evidence highlights neuroinflammation abnormalities as well as imbalances in neurotransmitters and the purinergic system in the pathophysiology of depression. However, little is known about the metabolomic changes in the hypothalamus of depressed patients with neuroinflammation. Herein, taking advantage of the well-established lipopolysaccharide (LPS)-induced depression mouse model, we measured metabolic changes in the hypothalamus using gas chromatography-mass spectrometry (GC-MS)...
November 21, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/29155300/mitochondrial-dysfunction-in-obesity
#14
REVIEW
Aline Haas de Mello, Ana Beatriz Costa, Jéssica Della Giustina Engel, Gislaine Tezza Rezin
Obesity leads to various changes in the body. Among them, the existing inflammatory process may lead to an increase in the production of reactive oxygen species (ROS) and cause oxidative stress. Oxidative stress, in turn, can trigger mitochondrial changes, which is called mitochondrial dysfunction. Moreover, excess nutrients supply (as it commonly is the case with obesity) can overwhelm the Krebs cycle and the mitochondrial respiratory chain, causing a mitochondrial dysfunction, and lead to a higher ROS formation...
November 16, 2017: Life Sciences
https://www.readbyqxmd.com/read/29139221/evaluation-of-hypothalamus-pituitary-thyroid-axis-function-by-chronic-perchlorate-exposure-in-male-rats
#15
Caroline Serrano-Nascimento, Jamile Calil-Silveira, Rafael Dalbosco, Telma Tenorio Zorn, Maria Tereza Nunes
Perchlorate is a widespread endocrine disruptor that was previously correlated with increased serum TSH levels and decreased thyroid hormones production both in animals and humans. Even so, the regulation of gene/protein expression in the hypothalamus, pituitary and thyroid by chronic perchlorate exposure was not completely elucidated. Therefore, this study aimed to investigate the underlying mechanisms involved in the disruption of hypothalamus-pituitary-thyroid axis by chronic perchlorate exposure. Male Wistar rats were treated or not with NaClO4 in the drinking water (35 mg/Kg/day) for 60 days...
November 15, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29125588/glucocorticoids-cause-gender-dependent-reversal-of-hepatic-fibrosis-in-the-mdr2-knockout-mouse-model
#16
Anca D Petrescu, Stephanie Grant, Gabriel Frampton, Jessica Kain, Karam Hadidi, Elaina Williams, Matthew McMillin, Sharon DeMorrow
Hepatic cholestasis is associated with a significant suppression of the hypothalamus-pituitary-adrenal axis (HPA). In the present study, we tested the hypothesis that activation of the HPA axis by corticosterone treatment can reverse liver inflammation and fibrosis in a multidrug resistance protein 2 knockout (MDR2KO) transgenic mouse model of hepatic cholestasis. Friend Virus B NIH-Jackson (FVBN) control and MDR2KO male and female mice were treated with vehicle or corticosterone for two weeks, then serum and liver analyses of hepatic cholestasis markers were performed...
November 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29077836/the-hypothalamic-inflammatory-gliosis-response-to-neonatal-overnutrition-is-sex-and-age-dependent
#17
Pilar Argente-Arizón, Francisca Díaz, Purificación Ros, Vicente Barrios, Manuel Tena-Sempere, Luis Miguel García-Segura, Jesús Argente, Julie A Chowen
Astrocytes participate in both physiological and pathophysiological responses to metabolic and nutrient signals. While most studies have focused on the astrocytic response to weight gain due to high fat/high carbohydrate intake, surplus intake of a balanced diet also induces excess weight gain. We have accessed the effects of neonatal overnutrition, which has both age and sex dependent effects on weight gain, on hypothalamic inflammation/gliosis. Although both male and female Wistar rats accumulate excessive fat mass as early as postnatal day (PND) 10 with neonatal overnutrition no increase in hypothalamic cytokine levels, markers of astrocytes or microglia, or inflammatory signaling pathways were observed...
October 25, 2017: Endocrinology
https://www.readbyqxmd.com/read/29074357/brewer-s-yeast-is-a-potent-inducer-of-fever-sickness-behavior-and-inflammation-within-the-brain
#18
R Dangarembizi, K H Erlwanger, C Rummel, J Roth, M T Madziva, L M Harden
Brewer's yeast, derived from the yeast species Saccharomyces cerevisiae, is commonly used for inducing pyrexia in pharmacological studies screening antipyretics in rats. Despite its widespread use, the peripheral and central inflammatory response associated with Brewer's yeast-induced fever and sickness behavior in rats has not been investigated. Thus, we injected male Sprague-Dawley rats (150 - 200 g) subcutaneously with a high (4 g/kg, n = 9), medium (2 g/kg, n = 5) or low (0.4 g/kg, n = 6) dose of Brewer's yeast solution or saline (0...
October 23, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29054292/addiction-a-dysregulation-of-satiety-and-inflammatory-processes
#19
Rivona Harricharan, Oualid Abboussi, William M U Daniels
Over the years, drug addiction has proven to be a perplexing conundrum for scientists. In attempts to decipher the components of the puzzle, multiple theories of addiction have been proposed. While these theories have assisted in providing essential fundamental information, current research recommends that a new theory needs to be presented taking into consideration the results of recent developments in the fields of neuroimmunology, genetics, and neuropsychiatry. After extensively examining the published literature, we propose in this review that neuroinflammation and hypothalamic functioning strongly underpin addictive behavior...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29053743/in-vitro-modeling-of-experimental-succinic-semialdehyde-dehydrogenase-deficiency-ssadhd-using-brain-derived-neural-stem-cells
#20
Kara R Vogel, Garrett R Ainslie, Erwin E Jansen, Gajja S Salomons, Jean-Baptiste Roullet, K Michael Gibson
We explored the utility of neural stem cells (NSCs) as an in vitro model for evaluating preclinical therapeutics in succinic semialdehyde dehydrogenase-deficient (SSADHD) mice. NSCs were obtained from aldh5a1+/+ and aldh5a1-/- mice (aldh5a1 = aldehyde dehydrogenase 5a1 = SSADH). Multiple parameters were evaluated including: (1) production of GHB (γ-hydroxybutyrate), the biochemical hallmark of SSADHD; (2) rescue from cell death with the dual mTOR (mechanistic target of rapamycin) inhibitor, XL-765, an agent previously shown to rescue aldh5a1-/- mice from premature lethality; (3) mitochondrial number, total reactive oxygen species, and mitochondrial superoxide production, all previously documented as abnormal in aldh5a1-/- mice; (4) total ATP levels and ATP consumption; and (5) selected gene expression profiles associated with epilepsy, a prominent feature in both experimental and human SSADHD...
2017: PloS One
keyword
keyword
46904
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"