keyword
MENU ▼
Read by QxMD icon Read
search

Hypothalamus inflammation

keyword
https://www.readbyqxmd.com/read/29139221/evaluation-of-hypothalamus-pituitary-thyroid-axis-function-by-chronic-perchlorate-exposure-in-male-rats
#1
Caroline Serrano-Nascimento, Jamile Calil-Silveira, Rafael Dalbosco, Telma Tenorio Zorn, Maria Tereza Nunes
Perchlorate is a widespread endocrine disruptor that was previously correlated with increased serum TSH levels and decreased thyroid hormones production both in animals and humans. Even so, the regulation of gene/protein expression in the hypothalamus, pituitary and thyroid by chronic perchlorate exposure was not completely elucidated. Therefore, this study aimed to investigate the underlying mechanisms involved in the disruption of hypothalamus-pituitary-thyroid axis by chronic perchlorate exposure. Male Wistar rats were treated or not with NaClO4 in the drinking water (35 mg/Kg/day) for 60 days...
November 15, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29125588/glucocorticoids-cause-gender-dependent-reversal-of-hepatic-fibrosis-in-the-mdr2-knockout-mouse-model
#2
Anca D Petrescu, Stephanie Grant, Gabriel Frampton, Jessica Kain, Karam Hadidi, Elaina Williams, Matthew McMillin, Sharon DeMorrow
Hepatic cholestasis is associated with a significant suppression of the hypothalamus-pituitary-adrenal axis (HPA). In the present study, we tested the hypothesis that activation of the HPA axis by corticosterone treatment can reverse liver inflammation and fibrosis in a multidrug resistance protein 2 knockout (MDR2KO) transgenic mouse model of hepatic cholestasis. Friend Virus B NIH-Jackson (FVBN) control and MDR2KO male and female mice were treated with vehicle or corticosterone for two weeks, then serum and liver analyses of hepatic cholestasis markers were performed...
November 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29077836/the-hypothalamic-inflammatory-gliosis-response-to-neonatal-overnutrition-is-sex-and-age-dependent
#3
Pilar Argente-Arizón, Francisca Díaz, Purificación Ros, Vicente Barrios, Manuel Tena-Sempere, Luis Miguel García-Segura, Jesús Argente, Julie A Chowen
Astrocytes participate in both physiological and pathophysiological responses to metabolic and nutrient signals. While most studies have focused on the astrocytic response to weight gain due to high fat/high carbohydrate intake, surplus intake of a balanced diet also induces excess weight gain. We have accessed the effects of neonatal overnutrition, which has both age and sex dependent effects on weight gain, on hypothalamic inflammation/gliosis. Although both male and female Wistar rats accumulate excessive fat mass as early as postnatal day (PND) 10 with neonatal overnutrition no increase in hypothalamic cytokine levels, markers of astrocytes or microglia, or inflammatory signaling pathways were observed...
October 25, 2017: Endocrinology
https://www.readbyqxmd.com/read/29074357/brewer-s-yeast-is-a-potent-inducer-of-fever-sickness-behavior-and-inflammation-within-the-brain
#4
R Dangarembizi, K H Erlwanger, C Rummel, J Roth, M T Madziva, L M Harden
Brewer's yeast, derived from the yeast species Saccharomyces cerevisiae, is commonly used for inducing pyrexia in pharmacological studies screening antipyretics in rats. Despite its widespread use, the peripheral and central inflammatory response associated with Brewer's yeast-induced fever and sickness behavior in rats has not been investigated. Thus, we injected male Sprague-Dawley rats (150 - 200 g) subcutaneously with a high (4 g/kg, n = 9), medium (2 g/kg, n = 5) or low (0.4 g/kg, n = 6) dose of Brewer's yeast solution or saline (0...
October 23, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29054292/addiction-a-dysregulation-of-satiety-and-inflammatory-processes
#5
Rivona Harricharan, Oualid Abboussi, William M U Daniels
Over the years, drug addiction has proven to be a perplexing conundrum for scientists. In attempts to decipher the components of the puzzle, multiple theories of addiction have been proposed. While these theories have assisted in providing essential fundamental information, current research recommends that a new theory needs to be presented taking into consideration the results of recent developments in the fields of neuroimmunology, genetics, and neuropsychiatry. After extensively examining the published literature, we propose in this review that neuroinflammation and hypothalamic functioning strongly underpin addictive behavior...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29053743/in-vitro-modeling-of-experimental-succinic-semialdehyde-dehydrogenase-deficiency-ssadhd-using-brain-derived-neural-stem-cells
#6
Kara R Vogel, Garrett R Ainslie, Erwin E Jansen, Gajja S Salomons, Jean-Baptiste Roullet, K Michael Gibson
We explored the utility of neural stem cells (NSCs) as an in vitro model for evaluating preclinical therapeutics in succinic semialdehyde dehydrogenase-deficient (SSADHD) mice. NSCs were obtained from aldh5a1+/+ and aldh5a1-/- mice (aldh5a1 = aldehyde dehydrogenase 5a1 = SSADH). Multiple parameters were evaluated including: (1) production of GHB (γ-hydroxybutyrate), the biochemical hallmark of SSADHD; (2) rescue from cell death with the dual mTOR (mechanistic target of rapamycin) inhibitor, XL-765, an agent previously shown to rescue aldh5a1-/- mice from premature lethality; (3) mitochondrial number, total reactive oxygen species, and mitochondrial superoxide production, all previously documented as abnormal in aldh5a1-/- mice; (4) total ATP levels and ATP consumption; and (5) selected gene expression profiles associated with epilepsy, a prominent feature in both experimental and human SSADHD...
2017: PloS One
https://www.readbyqxmd.com/read/29032150/functional-analysis-of-schizophrenia-genes-using-geneanalytics-program-and-integrated-databases
#7
Tharani Sundararajan, Ann M Manzardo, Merlin G Butler
Schizophrenia (SCZ) is a chronic debilitating neuropsychiatric disorder with multiple risk factors involving numerous complex genetic influences. We examined and updated a master list of clinically relevant and susceptibility genes associated with SCZ reported in the literature and genomic databases dedicated to gene discovery for characterization of SCZ genes. We used the commercially available GeneAnalytics computer-based gene analysis program and integrated genomic databases to create a molecular profile of the updated list of 608 SCZ genes to model their impact in select categories (tissues and cells, diseases, pathways, biological processes, molecular functions, phenotypes and compounds) using specialized GeneAnalytics algorithms...
October 12, 2017: Gene
https://www.readbyqxmd.com/read/28993246/vitamin-d-and-the-paraventricular-nucleus-relevance-for-type-2-diabetes
#8
Keisha Harrison, Stephanie Sisley
Vitamin D deficiency is linked to type 2 diabetes and we recently showed this may be through action of vitamin D in the paraventricular nuclei (PVN) in the hypothalamus of the brain. This review focuses on the known roles of the PVN in glucose control and how previously discovered actions of vitamin D in other tissues may translate to action in the PVN. Specifically, we focus on the role of insulin and inflammation in the hypothalamus and how these may be modified through vitamin D action.
October 6, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28988760/the-effects-of-overnight-nutrient-intake-on-hypothalamic-inflammation-in-a-free-choice-diet-induced-obesity-rat-model
#9
Evita Belegri, Leslie Eggels, Unga A Unmehopa, Joram D Mul, Anita Boelen, Susanne E la Fleur
Consumption of fat and sugar induces hyperphagia and increases the prevalence of obesity and diabetes type 2. Low-grade inflammation in the hypothalamus, a key brain area involved in the regulation of energy homeostasis is shown to blunt signals of satiety after long term high fat diet. The fact that this mechanism can be activated after a few days of hyperphagia before apparent obesity is present led to our hypothesis that hypothalamic inflammation is induced with fat and sugar consumption. Here, we used a free-choice high-fat high-sugar (fcHFHS) diet-induced obesity model and tested the effects of differential overnight nutrient intake during the final experimental night on markers of hypothalamic inflammation...
January 1, 2018: Appetite
https://www.readbyqxmd.com/read/28968517/probiotics-modulate-gut-microbiota-and-improve-insulin-sensitivity-in-dio-mice
#10
Renata A Bagarolli, Natália Tobar, Alexandre G Oliveira, Tiago G Araújo, Bruno M Carvalho, Guilherme Z Rocha, Juliana F Vecina, Kelly Calisto, Dioze Guadagnini, Patrícia O Prada, Andrey Santos, Sara T O Saad, Mario J A Saad
Obesity and type 2 diabetes are characterized by subclinical inflammatory process. Changes in composition or modulation of the gut microbiota may play an important role in the obesity-associated inflammatory process. In the current study, we evaluated the effects of probiotics (Lactobacillus rhamnosus, L. acidophilus and Bifidobacterium bifidumi) on gut microbiota, changes in permeability, and insulin sensitivity and signaling in high-fat diet and control animals. More importantly, we investigated the effects of these gut modulations on hypothalamic control of food intake, and insulin and leptin signaling...
August 26, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28943448/molecular-integration-of-incretin-and-glucocorticoid-action-reverses-immunometabolic-dysfunction-and-obesity
#11
Carmelo Quarta, Christoffer Clemmensen, Zhimeng Zhu, Bin Yang, Sini S Joseph, Dominik Lutter, Chun-Xia Yi, Elisabeth Graf, Cristina García-Cáceres, Beata Legutko, Katrin Fischer, Robert Brommage, Philippe Zizzari, Bernardo S Franklin, Martin Krueger, Marco Koch, Sabine Vettorazzi, Pengyun Li, Susanna M Hofmann, Mostafa Bakhti, Aimée Bastidas-Ponce, Heiko Lickert, Tim M Strom, Valerie Gailus-Durner, Ingo Bechmann, Diego Perez-Tilve, Jan Tuckermann, Martin Hrabě de Angelis, Darleen Sandoval, Daniela Cota, Eicke Latz, Randy J Seeley, Timo D Müller, Richard D DiMarchi, Brian Finan, Matthias H Tschöp
Chronic inflammation has been proposed to contribute to the pathogenesis of diet-induced obesity. However, scarce therapeutic options are available to treat obesity and the associated immunometabolic complications. Glucocorticoids are routinely employed for the management of inflammatory diseases, but their pleiotropic nature leads to detrimental metabolic side effects. We developed a glucagon-like peptide-1 (GLP-1)-dexamethasone co-agonist in which GLP-1 selectively delivers dexamethasone to GLP-1 receptor-expressing cells...
October 3, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28933062/hypothalamic-dysfunction-in-obesity-and-metabolic-disorders
#12
Sara Carmo-Silva, Cláudia Cavadas
The hypothalamus is the brain region responsible for the maintenance of energetic homeostasis. The regulation of this process arises from the ability of the hypothalamus to orchestrate complex physiological responses such as food intake and energy expenditure, circadian rhythm, stress response, and fertility. Metabolic alterations such as obesity can compromise these hypothalamic regulatory functions. Alterations in circadian rhythm, stress response, and fertility further contribute to aggravate the metabolic dysfunction of obesity and contribute to the development of chronic disorders such as depression and infertility...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28893563/the-impact-of-murine-lrrk2-g2019s-transgene-overexpression-on-acute-responses-to-inflammatory-challenge
#13
Darcy Litteljohn, Chris Rudyk, Zach Dwyer, Kyle Farmer, Teresa Fortin, Shawn Hayley
The most common Parkinson's disease (PD) mutation is the gain-of-function LRRK2 G2019S variant, which has also been linked to inflammatory disease states. Yet, little is known of the role of G2019S in PD related complex behavioral or immune/hormonal processes in response to inflammatory/toxicant challenges. Hence, we characterized the behavioural, neuroendocrine-immune and central monoaminergic responses in G2019S overexpressing mutants following systemic interferon-gamma (IFN-γ) or lipopolysaccharide (LPS) administration...
September 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28865476/inhibition-of-hypothalamic-leukemia-inhibitory-factor-exacerbates-diet-induced-obesity-phenotype
#14
Milena Fioravante, Bruna Bombassaro, Albina F Ramalho, Nathalia R Dragano, Joseane Morari, Carina Solon, Natalia Tobar, Celso D Ramos, Licio A Velloso
BACKGROUND: The consumption of large amounts of dietary fats can trigger an inflammatory response in the hypothalamus and contribute to the dysfunctional control of caloric intake and energy expenditure commonly present in obesity. The objective of this study was to identify chemokine-related transcripts that could be involved in the early stages of diet-induced hypothalamic inflammation. METHODS: We used immunoblot, PCR array, real-time PCR, immunofluorescence staining, glucose and insulin tolerance tests, and determination of general metabolic parameters to evaluate markers of inflammation, body mass variation, and glucose tolerance in mice fed a high-fat diet...
September 2, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28855891/hypothalamic-inflammation-and-energy-balance-disruptions-spotlight-on-chemokines
#15
REVIEW
Ophélia Le Thuc, Katharina Stobbe, Céline Cansell, Jean-Louis Nahon, Nicolas Blondeau, Carole Rovère
The hypothalamus is a key brain region in the regulation of energy balance as it controls food intake and both energy storage and expenditure through integration of humoral, neural, and nutrient-related signals and cues. Many years of research have focused on the regulation of energy balance by hypothalamic neurons, but the most recent findings suggest that neurons and glial cells, such as microglia and astrocytes, in the hypothalamus actually orchestrate together several metabolic functions. Because glial cells have been described as mediators of inflammatory processes in the brain, the existence of a causal link between hypothalamic inflammation and the deregulations of feeding behavior, leading to involuntary weight loss or obesity for example, has been suggested...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28854149/chronic-exercise-reduces-hypothalamic-transforming-growth-factor-%C3%AE-1-in-middle-aged-obese-mice
#16
Vagner R R Silva, Carlos K Katashima, Luciene Lenhare, Carla G B Silva, Joseane Morari, Rafael L Camargo, Licio A Velloso, Mario A Saad, Adelino S R da Silva, Jose Rodrigo Pauli, Eduardo Rochete Ropelle
Obesity and aging are associated with hypothalamic inflammation, hyperphagia and abnormalities in the thermogenesis control. It has been demonstrated that the association between aging and obesity induces hypothalamic inflammation and metabolic disorders, at least in part, through the atypical hypothalamic transforming growth factor-β (TGF-β1). Physical exercise has been used to modulate several metabolic parameters. Thus, the aim of this study was to evaluate the impact of chronic exercise on TGF-β1 expression in the hypothalamus of Middle-Aged mice submitted to a one year of high-fat diet (HFD) treatment...
August 28, 2017: Aging
https://www.readbyqxmd.com/read/28852125/irf2bp2-deficient-microglia-block-the-anxiolytic-effect-of-enhanced-postnatal-care
#17
Aswin Hari, Shelly A Cruz, Zhaohong Qin, Pascal Couture, Ragnar O Vilmundarson, Hua Huang, Alexandre F R Stewart, Hsiao-Huei Chen
Enhanced postnatal care (EPC) increases resilience to adversity in adulthood. Since microglia participate in shaping neural circuits, we asked how ablation of an inflammation-suppressing factor IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) in microglia would affect the responses to EPC. Mice lacking IRF2BP2 in microglia (KO) and littermate controls (WT) were subjected to EPC during the first 3 weeks after birth. EPC reduced anxiety in WT but not KO mice. This was associated with reduced inflammatory cytokine expression in the hypothalamus...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821663/agrp-neurons-can-increase-food-intake-during-conditions-of-appetite-suppression-and-inhibit-anorexigenic-parabrachial-neurons
#18
Rachel A Essner, Alison G Smith, Adam A Jamnik, Anna R Ryba, Zoe D Trutner, Matthew E Carter
To maintain energy homeostasis, orexigenic (appetite-inducing) and anorexigenic (appetite suppressing) brain systems functionally interact to regulate food intake. Within the hypothalamus, neurons that express agouti-related protein (AgRP) sense orexigenic factors and orchestrate an increase in food-seeking behavior. In contrast, calcitonin gene-related peptide (CGRP)-expressing neurons in the parabrachial nucleus (PBN) suppress feeding. PBN CGRP neurons become active in response to anorexigenic hormones released following a meal, including amylin, secreted by the pancreas, and cholecystokinin (CCK), secreted by the small intestine...
September 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28809157/brain-micro-inflammation-at-specific-vessels-dysregulates-organ-homeostasis-via-the-activation-of-a-new-neural-circuit
#19
Yasunobu Arima, Takuto Ohki, Naoki Nishikawa, Kotaro Higuchi, Mitsutoshi Ota, Yuki Tanaka, Junko Nio-Kobayashi, Mohamed Elfeky, Ryota Sakai, Yuki Mori, Tadafumi Kawamoto, Andrea Stofkova, Yukihiro Sakashita, Yuji Morimoto, Masaki Kuwatani, Toshihiko Iwanaga, Yoshichika Yoshioka, Naoya Sakamoto, Akihiko Yoshimura, Mitsuyoshi Takiguchi, Saburo Sakoda, Marco Prinz, Daisuke Kamimura, Masaaki Murakami
Impact of stress on diseases including gastrointestinal failure is well-known, but molecular mechanism is not understood. Here we show underlying molecular mechanism using EAE mice. Under stress conditions, EAE caused severe gastrointestinal failure with high-mortality. Mechanistically, autoreactive-pathogenic CD4+ T cells accumulated at specific vessels of boundary area of third-ventricle, thalamus, and dentate-gyrus to establish brain micro-inflammation via stress-gateway reflex. Importantly, induction of brain micro-inflammation at specific vessels by cytokine injection was sufficient to establish fatal gastrointestinal failure...
August 15, 2017: ELife
https://www.readbyqxmd.com/read/28808144/particulate-matter-exposure-and-stress-hormone-levels-a-randomized-double-blind-crossover-trial-of-air-purification
#20
RANDOMIZED CONTROLLED TRIAL
Huichu Li, Jing Cai, Renjie Chen, Zhuohui Zhao, Zhekang Ying, Lin Wang, Jianmin Chen, Ke Hao, Patrick L Kinney, Honglei Chen, Haidong Kan
BACKGROUND: Exposure to ambient particulate matter (PM) is associated with a number of adverse health outcomes, but potential mechanisms are largely unknown. Metabolomics represents a powerful approach to study global metabolic changes in response to environmental exposures. We therefore conducted this study to investigate changes in serum metabolites in response to the reduction of PM exposure among healthy college students. METHODS: We conducted a randomized, double-blind crossover trial in 55 healthy college students in Shanghai, China...
August 15, 2017: Circulation
keyword
keyword
46904
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"