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https://www.readbyqxmd.com/read/28827968/evaluation-of-antioxidant-and-hepatoprotective-activity-of-fruit-rind-extract-of-garcinia-dulcis-roxburgh-kurz
#1
Nabajyoti Gogoi, Ankur Gogoi, Bijoy Neog, Dibyojyoti Baruah, Khumanthem Deepak Singh
BACKGROUND: Garcinia spp. belongs to the family Clusiaceae has been traditionally used for the treatment of many ailments including the liver damage. Garcinia dulcis found in North Eastern region of Assam; India can be a potential candidature to combat different ailments. Objective: The present work has been designed in such a way to appraisal the antioxidant and hepatoprotective activity of fruit rind extract of this plant. MATERIALS AND METHODS: The antioxidant activity was investigated through the various in vitro models, namely, 2,2-diphenyl-1-picrylhydrazine, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid, nitrite oxide...
July 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28827962/high-performance-thin-layer-chromatography-densitometry-method-for-determination-of-rubraxanthone-in-the-stem-bark-extract-of-garcinia-cowa-roxb
#2
Dachriyanus Hamidi, Hilyatul Aulia, Meri Susanti
CONTEXT: Garcinia cowa is a medicinal plant widely grown in Southeast Asia and tropical countries. Various parts of this plant have been used in traditional folk medicine. The bark, latex, and root have been used as an antipyretic agent, while fruit and leaves have been used as an expectorant, for indigestion and improvement of blood circulation. AIMS: This study aims to determine the concentration of rubraxanthone found in ethyl acetate extract of the stem bark of G...
July 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28827919/cerebellar-molecular-and-cellular-characterization-in-rat-models-of-alzheimer-s-disease-neuroprotective-mechanisms-of-garcinia-biflavonoid-complex
#3
Olayemi Joseph Olajide, Anita Temi Ugbosanmi, Bernard Ufuoma Enaibe, Kehinde Yomi Ogunrinola, Susan Folashade Lewu, Nnaemeka Tobechukwu Asogwa, Tosan Akapa, Aminu Imam, Abdulmumin Ibrahim, Ismail Temitayo Gbadamosi, Emmanuel Olusola Yawson
BACKGROUND: Recent evidences suggest that cerebellar degeneration may be associated with the development of Alzheimer's disease (AD). However, previous reports were mainly observational, lacking substantial characterization of cellular and molecular cerebellar features during AD progression. PURPOSE: This study is aimed at characterizing the cerebellum in rat models of AD and assessing the corresponding neuroprotective mechanisms of Garcinia biflavonoid complex (GBc)...
May 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28822990/%C3%AE-%C3%AE-mangostins-induces-autophagy-and-shows-synergistic-effectwith-gemcitabine-in-pancreatic-cancer-cell-lines
#4
Myoungjae Kim, Young-Won Chin, Eun Joo Lee
Pancreatic cancer is one of the most lethal and aggressive cancers in the world. However, no effective treatment is currently available for pancreatic cancer. The objective of this study was to determine the anti-pancreatic cancer effect of α-mangostin (αM) and γ-mangostin (γM) extracted from the pericarp of Garcinia mangostana L.. Both αM and γM reduced the viability of pancreatic cancer cells MIA PaCa-2 and PANC-1 in a dose-dependent manner. These compounds induced apoptosis by increasing c-PARP and c-Caspase 3 levels...
August 21, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28822616/the-garcinia-kola-biflavonoid-kolaviron-attenuates-experimental-hepatotoxicity-induced-by-diclofenac
#5
Quadri Kunle Alabi, Rufus Ojo Akomolafe, Olaoluwa Sesan Olukiran, Wale Johnson Adeyemi, Aliyat Olajumoke Nafiu, Modinat Adebukola Adefisayo, Joseph Gbenga Omole, Deborah Ifeoluwa Kajewole, Oluwole Olaniyi Odujoko
This study sought to investigate the effects of kolaviron on diclofenac-induced hepatotoxicity in rats. Sixty male Wistar rats were divided into 6 groups of 10 rats each as follows: a control group that received oral propylene glycol and treatment groups that received diclofenac alone, diclofenac followed by Livolin Forte (a reference drug), or diclofenac followed by kolaviron at three different doses. At the end of the study period, five rats per group were sacrificed under ketamine hydrochloride anesthetic, 24h after treatment, while the other 5 rats in the group were allowed to recover for 2 weeks before being sacrificed...
August 16, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28814920/garcinia-hopii-clusiaceae-a-new-species-from-bidoup-nui-ba-national-park-southern-vietnam
#6
Hironori Toyama, Van-Son Dang, Shuichiro Tagane, Ngoc Van Nguyen, Akiyo Naiki, Hidetoshi Nagamasu, Tetsukazu Yahara
A new species, Garcinia hopii H.Toyama & V.S.Dang is described from Bidoup Nui Ba National Park, southern Vietnam. This species is similar to Garcinia hendersoniana Whitmore but differs from that species in having larger leaves, clustered pistillate flowers, a greater number of sterile anthers and a larger stigma of young fruits. A description, preliminary conservation assessment, illustration, photographs and DNA barcodes of the new species are provided, as well as an updated key to Garcinia sect. Hebradendron in Indochina...
2017: PhytoKeys
https://www.readbyqxmd.com/read/28808396/catechin-isolated-from-garcinia-celebica-leaves-inhibit-plasmodium-falciparum-growth-through-the-induction-of-oxidative-stress
#7
Rizky Abdulah, Eka W Suradji, Anas Subarnas, Unang Supratman, Milyadi Sugijanto, Ajeng Diantini, Keri Lestari, Melisa I Barliana, Shinichiro Kawazu, Hiroshi Koyama
BACKGROUND: Resistance of antimalarial drugs to Plasmodium falciparum has become a major concern in malaria eradication. Although it is also affected by several socioeconomic factors, a new antiplasmodial agent is needed for a global malaria control program. OBJECTIVE: In this study, we attempted to uncover the antiplasmodial properties of Garcinia celebica, an Indonesian medicinal plant, along with the responsible compound and its possible mechanism. MATERIALS AND METHODS: The G...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28782393/chemical-composition-and-cytotoxic-activity-of-garcinia-atroviridis-griff-ex-t-anders-essential-oils-in-combination-with-tamoxifen
#8
Wen-Nee Tan, Jia-Qin Lim, Fatin Afiqah, Nik Nur Syazni Nik Mohamed Kamal, Fatin Athirah Abdul Aziz, Woei-Yenn Tong, Chean-Ring Leong, Jun-Wei Lim
Garcinia atroviridis Griff. ex T. Anders. is used as a medication agent in folkloric medicine. The present study was to examine the chemical composition of the stem bark and leaf of G. atroviridis as well as their cytotoxic effects against MCF-7 cells. The constituents obtained by hydrodistillation were identified using GC-MS. The stem bark oil (EO-SB) composed mainly the palmitoleic acid (51.9%) and palmitic acid (21.9%), while the leaf oil (EO-L) was dominated by (E)-β-farnesene (58.5%) and β-caryophyllene (16...
August 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28777081/binding-of-hydroxycitrate-to-human-atp-citrate-lyase
#9
Jinhong Hu, Aruna Komakula, Marie E Fraser
Hydroxycitrate from the fruit of Garcinia cambogia [i.e. (2S,3S)-2-hydroxycitrate] is the best-known inhibitor of ATP-citrate lyase. Well diffracting crystals showing how the inhibitor binds to human ATP-citrate lyase were grown by modifying the protein. The protein was modified by introducing cleavage sites for Tobacco etch virus protease on either side of a disordered linker. The protein crystallized consisted of residues 2-425-ENLYFQ and S-488-810 of human ATP-citrate lyase. (2S,3S)-2-Hydroxycitrate binds in the same orientation as citrate, but the citrate-binding domain (residues 248-421) adopts a different orientation with respect to the rest of the protein (residues 4-247, 490-746 and 748-809) from that previously seen...
August 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28757558/the-bionomics-of-the-cocoa-mealybug-exallomochlus-hispidus-morrison-hemiptera-pseudococcidae-on-mangosteen-fruit-and-three-alternative-hosts
#10
Murni Indarwatmi, Dadang Dadang, Sobir Ridwani, Endang Sri Ratna
The cocoa mealybug, Exallomochlus hispidus Morrison (Hemiptera: Pseudococcidae) is known to attack mangosteen, an important fruit export commodity for Indonesia. The mealybug is polyphagous, so alternative host plants can serve as a source of nourishment. This study aimed to record the bionomics of E. hispidus on mangosteen (Garcinia mangostana L.) and three alternative hosts, kabocha squash (Cucurbita maxima L.), soursop (Annona muricata, L.), and guava (Psidium guajava L.). First-instar nymphs of the E. hispidus were reared at room temperature on mangosteen, kabocha, soursop, and guava fruits until they developed into adults and produced nymphs...
July 25, 2017: Insects
https://www.readbyqxmd.com/read/28741279/identification-of-lead-molecules-in-garcinia-mangostana-l-against-pancreatic-cholesterol-esterase-activity-an-in-silico-approach
#11
George Kadakasseril Varghese, Rini Abraham, Nisha N Chandran, Solomon Habtemariam
Hypercholesterolemia is one of the major risk factors for the development and progression of atherosclerosis. Hence, inhibitors of cholesterol absorption have been investigated for decades as a strategy to prevent and treat cardiovascular diseases associated with hypercholesterolemia. Cholesterol esterase (CEase) in pancreatic juice plays a vital role in the hydrolysis of dietary cholesterol esters to cholesterol and fatty acids. Since inhibition of CEase might lead to a reduction of cholesterol absorption, an attempt is made in this study to identify lead molecules of Garcinia mangostana by the in silico approach...
July 24, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28729053/bioactive-polyprenylated-benzophenone-derivatives-from-the-fruits-extracts-of-garcinia-xanthochymus
#12
Ui Joung Youn, Tawanun Sripisut, Gabriella Miklossy, James Turkson, Surat Laphookhieo, Leng Chee Chang
Two new polycyclic prenylated xanthones (1 and 2) and a new phenylpropanoid glycoside (3), along with seven known compounds (4-10) were isolated from the fruits of Garcinia xanthochymus. The structures were elucidated by 1D- and 2D-NMR, and HRMS experiments. The isolates were evaluated for their inhibitory effects against the viability of U251MG glioblastoma and MDA-MB-231 breast cancer cells that harbor an aberrantly active signal transducer and exhibit activation of transcription 3 (STAT3), and compared to normal NIH3T3 mouse fibroblasts...
July 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28715912/acetyl-and-o-alkyl-derivatives-of-%C3%AE-mangostin-from-garcinia-mangostana-and-their-anti-inflammatory-activities
#13
Thiruventhan Karunakaran, Gwendoline Cheng Lian Ee, Intan Safinar Ismail, Siti Mariam Mohd Nor, Nor Hisam Zamakshshari
Pure β-mangostin (1) was isolated from the stem bark of Garcinia mangostana L. One monoacetate (2) and five O-alkylated β-mangostin derivatives (3-7) were synthesised from β-mangostin. The structures of these compounds were elucidated and determined using spectroscopic techniques such as 1D NMR and MS. The cytotoxicities and anti-inflammatory activities of these five compounds against RAW cell 264.7 were tested. The structural-activity relationship studies indicated that β-mangostin showed a significant activity against the LPS-induced RAW cell 264...
July 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28715509/correction-a-naturally-occurring-histone-acetyltransferase-inhibitor-derived-from-garcinia-indica-impairs-newly-acquired-and-reactivated-fear-memories
#14
Stephanie A Maddox, Casey S Watts, Valérie Doyère, Glenn E Schafe
[This corrects the article DOI: 10.1371/journal.pone.0054463.].
2017: PloS One
https://www.readbyqxmd.com/read/28688721/separation-and-preparation-of-xanthochymol-and-guttiferone-e-by-high-performance-liquid-chromatography-and-high-speed-counter-current-chromatography-combined-with-silver-nitrate-coordination-reaction
#15
Jun Li, Ruixi Gao, Dan Zhao, Xianju Huang, Yu Chen, Fei Gan, Hui Liu, Guangzhong Yang
Xanthochymol (XCM) and guttiferone E (GFE), a pair of π bond benzophenone isomers from Garcinia xanthochymus, were once reported to be difficult or impossible to separate. The present study reports the successful separation of these two isomers through high performance liquid chromatography (HPLC), as well as their effective isolation using high speed counter-current chromatography (HSCCC) based on the silver nitrate (AgNO3) coordination reaction. First, an effective HPLC separation system was developed, achieving a successful baseline separation with resolution of 2...
July 4, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28674220/isolation-and-characterization-of-microsatellite-markers-in-garcinia-gummi-gutta-by-next-generation-sequencing-and-cross-species-amplification
#16
K V Ravishankar, R Vasudeva, Byatroy Hemanth, B S Sandya, B R Sthapit, V A Parthasarathy, V Ramanatha Rao
Garcinia gummi-gutta (L.) Roxb. (Clusiaceae) is an endemic, semidomesticated, fruit-yielding tree species distributed in the Western Ghats of India and Sri Lanka. Various bioactive phytochemicals, such as garcinol, benzophenones and xanthones are isolated from G. gummi-gutta and have shown antibacterial, antiviral and antioxidant activities. We sequenced the total genomic DNA using Illumina Hiseq 2000 platform and examined 241,141,804 bp high quality data, assembled into 773,889 contigs. In these contigs, 27,313 simple-sequence repeats (SSRs) were identified, among which mononucleotide repeats were predominant (44...
June 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28671595/anti-obesity-effect-of-the-above-ground-part-of-valeriana-dageletiana-nakai-ex-f-maek-extract-in-high-fat-diet-induced-obese-c57bl-6n-mice
#17
Zhiqiang Wang, Seung Hwan Hwang, Ju Hee Kim, Soon Sung Lim
Valeriana dageletiana Nakai ex F. Maek (VD) has been used as traditional medicine for the treatment of restlessness and sleeping disorders. However, it is still unclear whether obesity in mice can be altered by diet supplementation with VD. In this study, we first investigated the influences of VD on the accumulation of lipid content in 3T3-L1 cells; and the results showed that the above-ground VD extracts (VDAE) suppressed the differentiation of 3T3-L1 preadipocytes in a concentration-dependent manner without cytotoxicity...
July 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28665538/%C3%AE-glucosidase-inhibitory-xanthones-from-the-roots-of-garcinia-fusca
#18
Nam K Nguyen, Xuyen A Truong, Thai Q Bui, Dzung N Bui, Hai X Nguyen, Phuong T Tran, Lien-Hoa D Nguyen
An ethyl acetate extract of the roots of Garcinia fusca produced two new compounds, fuscaxanthones J (1) and K (2), together with eight known xanthones (3-10). Their structures were determined using spectroscopic methods, mainly 1-D and 2-D NMR. α-Glucosidase inhibitory activity of the isolated compounds was evaluated and fuscaxanthone J (1) showed the most significant effect with IC50 value of 8.3 ± 1.8 μM (compared with acarbose, IC50 = 214.5 ± 2.3 μM). This article is protected by copyright. All rights reserved...
June 30, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28656594/review-of-garcinia-mangostana-and-its-xanthones-in-metabolic-syndrome-and-related-complications
#19
REVIEW
Hourieh Tousian Shandiz, Bibi Marjan Razavi, Hossein Hosseinzadeh
Metabolic syndrome is coexistence of abdominal obesity, hyperglycemia, hyperlipidemia and hypertension that causes cardiovascular diseases, diabetes and their complications, low quality and short lifespan. Garcinia mangostana and its xanthones such as α-mangostin have been shown desirable effects such as anti-obesity, anti-hyperglycemic, anti-dyslipidemia, anti-diabetic and antiinflammatory effects in experimental studies. Various databases such as PubMed, Scopus and Web of Science with keywords of 'Garcinia mangostana', 'mangosteen', 'α-mangostin', 'metabolic syndrome', 'hypoglycemic', 'antihyperglicemic', 'antidiabetic', 'hypotensive', 'antihypertensive', 'atherosclerosis', 'arteriosclerosis' and 'hyperlipidemia' have been investigated in this search without publication time limitation...
August 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28641010/alpha-mangostin-reverses-multidrug-resistance-by-attenuating-the-function-of-the-multidrug-resistance-linked-abcg2-transporter
#20
Chung-Pu Wu, Sung-Han Hsiao, Megumi Murakami, Yu-Jen Lu, Yan-Qing Li, Yang-Hui Huang, Tai-Ho Hung, Suresh V Ambudkar, Yu-Shan Wu
The ATP-binding cassette (ABC) drug transporter ABCG2 can actively efflux a wide variety of chemotherapeutic agents out of cancer cells and subsequently reduce the intracellular accumulation of these drugs. Therefore, the overexpression of ABCG2 often contributes to the development of multidrug resistance (MDR) in cancer cells, which is one of the major obstacles to successful cancer chemotherapy. Moreover, ABCG2 is highly expressed in various tissues including the intestine and blood-brain barrier (BBB), limiting the absorption and bioavailability of many therapeutic agents...
August 7, 2017: Molecular Pharmaceutics
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