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https://www.readbyqxmd.com/read/29019929/chemical-and-biological-research-on-herbal-medicines-rich-in-xanthones
#1
REVIEW
Jingya Ruan, Chang Zheng, Yanxia Liu, Lu Qu, Haiyang Yu, Lifeng Han, Yi Zhang, Tao Wang
Xanthones, as some of the most active components and widely distributed in various herb medicines, have drawn more and more attention in recent years. So far, 168 species of herbal plants belong to 58 genera, 24 families have been reported to contain xanthones. Among them, Calophyllum, Cratoxylum, Cudrania, Garcinia, Gentiana, Hypericum and Swertia genera are plant resources with great development prospect. This paper summarizes the plant resources, bioactivity and the structure-activity relationships (SARs) of xanthones from references published over the last few decades, which may be useful for new drug research and development on xanthones...
October 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28982303/possible-garcinia-cambogia-induced-mania-with-psychosis-a-case-report
#2
David C Nguyen, Tysen K Timmer, Blair C Davison, Ian R McGrane
Garcinia cambogia is a Southeast Asian fruit becoming increasingly popular as a weight management supplement. Hydroxycitric acid (HCA) is the primary active ingredient which demonstrates serotonergic- and muscarinic-enhancing properties via inhibition of selective serotonin reuptake and acetylcholinesterase. We report a young adult female with no history of bipolar disorder who developed mania and psychosis approximately 1 week following initiation of G cambogia and the Cleanse and Detox™ dietary supplement manufactured by Apex Vitality Health...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28972943/kolaviron-and-garcinia-kola-attenuate-doxorubicin-induced-cardiotoxicity-in-wistar-rats
#3
Ademola Adetokunbo Oyagbemi, Temitayo Olutayo Omobowale, James Olukayode Olopade, Ebenezer Olatunde Farombi
Background The Garcinia kola seeds have been reported for its antibacterial, antioxidant, antidiabetic and also for its chemoprevention property. The use of doxorubicin as an anticancer drug has been accompanied with avalanche of side effects including cardiotoxicity. The aim of this study was to investigate the cardioprotective effect of Kolaviron and Garcinia kola and their mechanisms of action. Methods Sixty male rats (Wistar strain) were used in this study. They were divided into 6 groups (A-F) each containing 10 animals...
October 3, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28970109/metabolic-profiling-of-garcinia-mangostana-mangosteen-based-on-ripening-stages
#4
Anjaritha A R Parijadi, Sastia P Putri, Sobir Ridwani, Fenny M Dwivany, Eiichiro Fukusaki
Metabolomics is an emerging research field based on exhaustive metabolite profiling that have been proven useful to facilitate the study of postharvest fruit development and ripening. Specifically, tracking changes to the metabolome as fruit ripens should provide important clues for understanding ripening mechanisms and identify bio-markers to improve post-harvest technology of fruits. This study conducted a time-course metabolome analysis in mangosteen, an economically important tropical fruit valued for its flavor...
September 29, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28968624/garcinia-cambogia-diabetic-ketoacidosis-and-pancreatitis
#5
Tamara Bystrak, Miguel E Cervera-Hernandez, Nishitha Reddy, Zachary King, Jeffrey Bratberg
[Full article available at http://rimed.org/rimedicaljournal-2017-10.asp].
October 2, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28940510/local-indigenous-fruit-derived-juices-as-alternate-source-of-acidity-regulators
#6
Cassandra D'souza, Rosaline Fernandes, Subhash Kudale, Azza Silotry Naik
BACKGROUND: Acidity regulators are additives that alter and control food acidity. The objective of this study was to explore local indigenous fruits as source of natural acidity regulators. Juices extracted from Garcinia indica (kokum), Embilica officinalis (amla) and Tamarindus indica (tamarind) were used as acidulants for medium such as coconut milk and bottle gourd juice. The buffering capacity (β), acid composition, antioxidant activity and shelf-life study of the acidified media were estimated...
September 20, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28936043/the-potential-of-mangosteen-garcinia-mangostana-peel-extract-combined-with-demineralized-freeze-dried-bovine-bone-xenograft-to-reduce-ridge-resorption-and-alveolar-bone-regeneration-in-preserving-the-tooth-extraction-socket
#7
Utari Kresnoadi, Maretaningtias Dwi Ariani, Eha Djulaeha, Nike Hendrijantini
BACKGROUND: Following the extraction of a tooth, bone resorption can cause significant problems for a subsequent denture implant and restorative dentistry. Thus, the tooth extraction socket needs to be maintained to reduce the chance of any alveolar ridge bone resorption. OBJECTIVE: The objective of this study is to determine whether the administration of mangosteen peel extracts (MPEs), combined with demineralized freeze-dried bovine bone xenograft (DFBBX) materials for tooth extraction socket preservation, could potentially reduce inflammation by decreased the expression of nuclear factor κβ (NfKb) and receptor activator of nuclear factor-κβ ligand (RANKL), to inhibit alveolar bone resorption, and increased of bone morphogenetic protein-2 (BMP2) expressions to accelerate alveolar bone regeneration...
July 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/28931317/a-new-depsidone-derivative-from-the-leaves-of-garcinia-polyantha
#8
Alain Meli Lannang, Denis Kehdinga Sema, Simplice J N Tatsimo, V F Tsague Tankeu, Hycienth F Tegha, Jean Duplex Wansi, Yoshihito Shiono, Norbert Sewald
One new depsidone, polyanthadepsidone A (1), together with four known compounds were isolated from the dichloromethane extract of the leaves of Garcinia polyantha. The structures of all compounds were determined by comprehensive analyses of their 1D and 2D NMR and EI mass spectral data. All the isolates exhibited suppressive effect on phagocytosis response upon activation with serum opsonised zymosan in the IC50 range of 4.5-23.80 μM, tested in vitro for oxidative burst studies of whole blood.
September 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28926234/using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-based-chemometrics-for-the-identification-of-anti-angiogenic-biflavonoids-from-edible-garcinia-species
#9
Ping Li, Grace Gar-Lee Yue, Hin-Fai Kwok, Chun-Lin Long, Clara Bik-San Lau, Edward J Kennelly
Garcinia xanthochymus fruits are edible and also used in traditional medicine. Our previous work showed that the isolated natural products from G. xanthochymus fruits have displayed antioxidant activity and cytotoxicity in the colon cancer cells. In this study, we developed a strategy to correlate a zebrafish angiogenesis assay with ultra-performance liquid chromatography quadrupole time of flight mass spectrometry-based chemometric analysis to identify potential anti-angiogenic activity compounds from G. xanthochymus fruits...
September 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28901512/gambogic-acid-suppresses-inflammation-in-rheumatoid-arthritis-rats-via-pi3k-akt-mtor-signaling-pathway
#10
Xiaodan Wu, Li Long, Jian Liu, Jin Zhang, Tong Wu, Xixi Chen, Bing Zhou, Ting-Zhuo Lv
Gamboge is the dried resin secreted by the Garcinia maingayi gambogic tree and is a substance that may be used to treat a variety of diseases, exhibits anti‑tumor and detoxification effects and prevents bleeding. The primary active constituent is gambogic acid. The present study aimed to investigate the anti‑inflammatory effects of gambogic acid in rheumatoid arthritis (RA) rats and to elucidate the mechanisms by which these effects occur. The swelling degree, the clinical arthritic scoring and pain threshold measurements were used to evaluate the effects of gambogic acid on RA...
September 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28889733/garcinia-kola-seeds-may-prevent-cognitive-and-motor-dysfunctions-in-a-type-1-diabetes-mellitus-rat-model-partly-by-mitigating-neuroinflammation
#11
Paul F Seke Etet, Mohammed Farahna, Gwiria M H Satti, Yahia M Bushara, Ahmed El-Tahir, Muaawia A Hamza, Sayed Y Osman, Ambrose C Dibia, Lorella Vecchio
Background We reported recently that extracts of seeds of Garcinia kola, a plant with established hypoglycemic properties, prevented the loss of inflammation-sensible neuronal populations like Purkinje cells in a rat model of type 1 diabetes mellitus (T1DM). Here, we assessed G. kola extract ability to prevent the early cognitive and motor dysfunctions observed in this model. Methods Rats made diabetic by single injection of streptozotocin were treated daily with either vehicle solution (diabetic control group), insulin, or G...
April 15, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28878295/garcinone-e-induces-apoptosis-and-inhibits-migration-and-invasion-in-ovarian-cancer-cells
#12
Xiao-Huang Xu, Qian-Yu Liu, Ting Li, Jian-Lin Liu, Xin Chen, Li Huang, Wen-An Qiang, Xiuping Chen, Yitao Wang, Li-Gen Lin, Jin-Jian Lu
Ovarian cancer remains the most lethal gynecological malignant tumor. In this study, 24 xanthones were isolated and identified from the pericarps of mangosteen (Garcinia mangostana), and their anti-proliferative activities were tested in ovarian cancer cells. Garcinone E (GE) was found to exhibit excellent anti-proliferative effects among the tested xanthones. It significantly inhibited the proliferation in HEY, A2780, and A2780/Taxol cells as evidenced by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, lactate dehydrogenase (LDH) release assay, Hoechst 33342 staining, annexin V/PI staining, and JC-1 staining...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877777/metabolomics-reveals-the-mechanism-of-hydroxycitric-acid-promotion-of-protein-synthesis-and-inhibition-of-fatty-acid-synthesis-in-broiler-chickens
#13
M L Peng, J Han, L L Li, H T Ma
(-)-Hydroxycitric acid (HCA), a major component of Garcinia cambogia extracts, has been shown to suppress BW gain and fat accumulation in animals and humans. However, the mechanism remains unknown. In this study, gas chromatography-mass spectrometry was used to analyse serum metabolites, and principal component analysis and partial least-squares-discriminant analysis models were generated to analyse serum metabolite changes in broiler chickens after the administration of (-)-HCA at 0, 1000, 2000 and 3000 mg/kg diets for 28 days...
September 7, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28864423/alpha-mangostin-inhibits-both-dengue-virus-production-and-cytokine-chemokine-expression
#14
Mayuri Tarasuk, Pucharee Songprakhon, Pattamawan Chimma, Panudda Sratongno, Kesara Na-Bangchang, Pa-Thai Yenchitsomanus
Since severe dengue virus (DENV) infection in humans associates with both high viral load and massive cytokine production - referred to as "cytokine storm", an ideal drug for treatment of DENV infection should efficiently inhibit both virus production and cytokine expression. In searching for such an ideal drug, we discovered that α-mangostin (α-MG), a major bioactive compound purified from the pericarp of the mangosteen fruit (Garcinia mangostana Linn), which has been used in traditional medicine for several conditions including trauma, diarrhea, wound infection, pain, fever, and convulsion, inhibits both DENV production in cultured hepatocellular carcinoma HepG2 and Huh-7 cells, and cytokine/chemokine expression in HepG2 cells...
August 31, 2017: Virus Research
https://www.readbyqxmd.com/read/28861452/rna-seq-assembly-and-analysis-of-garcinia-mangostana-transcriptome-during-seed-germination
#15
Nur Diyana Kamal Azlan, Mohd Noor Mat Isa, Zamri Zainal
Garcinia mangostana is a tropical fruit plant rich in antioxidant and bears recalcitrant seeds. The extent of water loss and low temperature tolerable by recalcitrant seed varies from regular orthodox seeds. Present study generates transcriptome resources for G. mangostana to postulate potential transcriptome differences between recalcitrant and orthodox seeds during seed germination process. Raw reads of pooled samples used for the assembly have been deposited in genbank accession SRR5412332.
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28859900/inclusion-complex-from-cyclodextrin-grafted-hyaluronic-acid-and-pseudo-protein-as-biodegradable-nano-delivery-vehicle-for-gambogic-acid
#16
Ying Ji, Shuo Shan, Mingyu He, Chih-Chang Chu
β-Cyclodextrin can form inclusion complex with a series of guest molecules including phenyl moieties, and has gained considerable popularity in the study of supramolecular nanostructure. In this study, a biodegradable nanocomplex (HA(CD)-4Phe4 nanocomplex) was developed from β-cyclodextrin grafted hyaluronic acid (HA) and phenylalanine based poly(ester amide). The phenylalanine based poly(ester amide) is a biodegradable pseudo protein which provides the encapsulation capacity for gambogic acid (GA), a naturally-derived chemotherapeutic which has been effectively employed to treat multidrug resistant tumor...
August 30, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28858724/alpha-mangostin-protects-rat-articular-chondrocytes-against-il-1%C3%AE-induced-inflammation-and-slows-the-progression-of-osteoarthritis-in-a-rat-model
#17
Tianlong Pan, Dengying Wu, Ningyu Cai, Rong Chen, Xuchao Shi, Bin Li, Jun Pan
Osteoarthritis (OA) is a joint disease characterized by inflammation and cartilage degradation. α-Mangostin (α-MG), which can be isolated from the fruit of the tropical evergreen tree Garcinia mangostana-L, is known to have anti-inflammatory properties. The aim of the study was to investigate the use of α-MG in the treatment of OA, using both rat chondrocytes and an OA rat model induced by destabilization of the medial meniscus (DMM). Rat chondrocytes were pretreated with α-MG (0, 1.25, 2.5, and 5.0μg/ml for 24h) prior to stimulation with interleukin-1β (IL-1β) (10ng/ml for 24h)...
November 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28842267/medicinal-properties-of-mangosteen-garcinia-mangostana-l-a-comprehensive-update
#18
REVIEW
Berenice Ovalle-Magallanes, Dianelena Eugenio-Pérez, José Pedraza-Chaverri
Garcinia mangostana L. (Clusiaceae) is a tropical tree native to Southeast Asia known as mangosteen which fruits possess a distinctive and pleasant taste that has granted them the epithet of "queen of the fruits". The seeds and pericarps of the fruit have a long history of use in the traditional medicinal practices of the region, and beverages containing mangosteen pulp and pericarps are sold worldwide as nutritional supplements. The main phytochemicals present in the species are isoprenylated xanthones, a class of secondary metabolites with multiple reports of biological effects, such as antioxidant, pro-apoptotic, anti-proliferative, antinociceptive, anti-inflammatory, neuroprotective, hypoglycemic and anti-obesity...
August 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28841395/kolaviron-attenuates-ischemia-reperfusion-injury-in-the-stomach-of-rats
#19
Olugbenga Adeola Odukanmi, Adeola Temitope Salami, Onaara Peter Ashaolu, Adeoti Gbemisola Adegoke, Samuel Babafemi Olaleye
Kolaviron (KV), an active complex of at least three compounds in Garcinia kola seed known for its antioxidant and anti-inflammatory activity was investigated for its gastro-protective effect in the stomach of rats subjected to ischemia-reperfusion-induced gastric ulceration. Male adult Wistar rats (180 - 210 g) were used, randomized into six groups (n = 15) as follows; 1: control, 2: ulcerated untreated (UU), 3: KV alone (KVA), 4: KV + ulcer (KVU), 5: Ulcer + KV (UKV) and 6: Ulcer + omeprazole (20 mg/kg) (UOme)...
August 25, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28827968/evaluation-of-antioxidant-and-hepatoprotective-activity-of-fruit-rind-extract-of-garcinia-dulcis-roxburgh-kurz
#20
Nabajyoti Gogoi, Ankur Gogoi, Bijoy Neog, Dibyojyoti Baruah, Khumanthem Deepak Singh
BACKGROUND: Garcinia spp. belongs to the family Clusiaceae has been traditionally used for the treatment of many ailments including the liver damage. Garcinia dulcis found in North Eastern region of Assam; India can be a potential candidature to combat different ailments. Objective: The present work has been designed in such a way to appraisal the antioxidant and hepatoprotective activity of fruit rind extract of this plant. MATERIALS AND METHODS: The antioxidant activity was investigated through the various in vitro models, namely, 2,2-diphenyl-1-picrylhydrazine, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid, nitrite oxide...
July 2017: Pharmacognosy Research
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