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https://www.readbyqxmd.com/read/27904492/hydroxycitric-acid-ameliorates-inflammation-and-oxidative-stress-in-mouse-models-of-multiple-sclerosis
#1
Mahdi Goudarzvand, Sanaz Afraei, Somaye Yaslianifard, Saleh Ghiasy, Ghazal Sadri, Mustafa Kalvandi, Tina Alinia, Ali Mohebbi, Reza Yazdani, Shahin Khadem Azarian, Abbas Mirshafiey, Gholamreza Azizi
Hydroxycitric acid (HCA) is derived primarily from the Garcinia plant and is widely used for its anti-inflammatory effects. Multiple sclerosis can cause an inflammatory demyelination and axonal damage. In this study, to validate the hypothesis that HCA exhibits therapeutic effects on multiple sclerosis, we established female C57BL/6 mouse models of multiple sclerosis, i.e., experimental autoimmune encephalomyelitis, using Complete Freund's Adjuvant (CFA) emulsion containing myelin oligodendrocyte glycoprotein (35-55)...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27885554/short-term-effects-of-a-green-coffee-extract-garcinia-c-ambogia-and-l-carnitine-containing-chewing-gum-on-snack-intake-and-appetite-regulation
#2
Cecilia Bobillo, Graham Finlayson, Ana Martínez, Daniela Fischman, Analisa Beneitez, Alejandro J Ferrero, Belisario E Fernández, Marcos A Mayer
INTRODUCTION: Different studies have assessed the influence of chewing gum to aid control of appetite and reduce food intake. PURPOSE: The aims of the present study were to evaluate the effects of chewing gum on satiety, food hedonics and snack intake and to explore the potential effects of the combination of Garcinia c ambogia, green coffee extract and L-carnitine on satiety, when administered in a gum format. METHODS: This was a prospective study in which 57 subjects randomly received three kinds of treatments, in a crossover design: (1) active gum; (2) placebo gum; and (3) no gum...
November 24, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27855137/garcinol-upregulates-gabaa-and-gad65-expression-modulates-bdnf-trkb-pathway-to-reduce-seizures-in-pentylenetetrazole-ptz-induced-epilepsy
#3
Fang Hao, Li-Hua Jia, Xiao-Wan Li, Ying-Rui Zhang, Xue-Wu Liu
BACKGROUND Epilepsy is the most predominant neurological disorder characterized by recurrent seizures. Despite treatment with antiepileptic drugs, epilepsy still is a challenge to treat, due to the associated adverse effects of the drugs. Previous investigations have shown critical roles of BDNF-TrkB signalling and expression of glutamic acid decarboxylase 65 (GAD65) and GABAA in the brain during epilepsy. Thus, drugs that could modulate BDNF-TrkB signal and expression of GAD65 and GABAA could aid in therapy...
November 17, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27842536/antibacterial-and-cytotoxic-cytochalasins-from-the-endophytic-fungus-phomopsis-sp-harbored-in-garcinia-kola-heckel-nut
#4
Jean-Bosco Jouda, Jean-de-Dieu Tamokou, Céline Djama Mbazoa, Clovis Douala-Meli, Prodipta Sarkar, Prasanta Kumar Bag, Jean Wandji
BACKGROUND: The continuous emergence of multidrug-resistant (MDR) bacteria drastically reduced the efficacy of our antibiotic armory and consequently, increased the frequency of therapeutic failure. The search for bioactive constituents from endophytic fungi against MDR bacteria became a necessity for alternative and promising strategies, and for the development of novel therapeutic solutions. We report here the isolation and structure elucidation of antibacterial and cytotoxic compounds from Phomopsis sp...
November 14, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27825990/garcinia-kola-aqueous-suspension-prevents-cerebellar-neurodegeneration-in-long-term-diabetic-rat-a-type-1-diabetes-mellitus-model
#5
Mohammed Farahna, Paul F Seke Etet, Sayed Y Osman, Kıymet K Yurt, Naheed Amir, Lorella Vecchio, Isınsu Aydin, Yousef H Aldebasi, Azimullah Sheikh, John C Chijuka, Süleyman Kaplan, Abdu Adem
ETHNOPHARMACOLOGICAL RELEVANCE: The development of compounds able to improve metabolic syndrome and mitigate complications caused by inappropriate glycemic control in type 1 diabetes mellitus is challenging. The medicinal plant with established hypoglycemic properties Garcinia kola Heckel might have the potential to mitigate diabetes mellitus metabolic syndrome and complications. AIM OF THE STUDY: We have investigated the neuroprotective properties of a suspension of G...
November 5, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27806646/secondary-metabolites-from-aspergillus-japonicus-cam231-an-endophytic-fungus-associated-with-garcinia-preussii
#6
Jean-Bosco Jouda, Judith-Laure Demgne Fopossi, Francine Mediesse Kengne, Céline Djama Mbazoa, Christopher Golz, Carsten Strohmann, Simeon Kouam Fogue, Jean Wandji
Chemical investigation of Aspergillus japonicus CAM231, isolated from the leaf of Garcina preussii collected in Cameroon, yielded two new compounds; one pyrone derivative, hydroxy neovasinin (1) and one phenol derivative, asperolan (2), together with two known compounds neovasifurarone B (3) and variecolin (4). The structures of the two new compounds were established using intensive NMR spectroscopy and HRMS spectra in comparison with data found in literature. The structure of compound 1 was confirmed by single-crystal X-ray crystallographic analysis in combination with NOESY experiment...
November 3, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27799215/caged-garcinia-xanthones-a-novel-chemical-scaffold-with-potent-antimalarial-activity
#7
Hangjun Ke, Joanne M Morrisey, Shiwei Qu, Oraphin Chantarasriwong, Michael W Mather, Emmanuel A Theodorakis, Akhil B Vaidya
Caged Garcinia xanthones (CGXs) constitute a family of natural products that are produced by tropical/sub-tropical trees of the genus Garcinia CGXs have a unique chemical architecture, defined by the presence of a caged scaffold at the C ring of a xanthone moiety and exhibit a broad range of biological activities. Here we show that synthetic CGXs exhibit antimalarial activity against Plasmodium falciparum, the causative parasite of human malaria, at the intra-erythrocytic stages. The activity can be substantially improved by attaching a triphenylphosphonium group at the A ring of the caged xanthone...
October 31, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27793565/cytotoxic-lanostanes-from-fruits-of-garcinia-wallichii-choisy-guttiferae
#8
Sakchai Hongthong, Jatuporn Meesin, Phanruethai Pailee, Darunee Soorukram, Palangpon Kongsaeree, Samran Prabpai, Pawinee Piyachaturawat, Surawat Jariyawat, Kanoknetr Suksen, Thaworn Jaipetch, Narong Nuntasaen, Vichai Reutrakul, Chutima Kuhakarn
Five new lanostanes, wallichinanes A-E (1-5) together with a known lanostane derivative 6 were isolated from the cytotoxic hexanes extract of fruits of Garcinia wallichii Choisy (Guttiferae). The structures of the isolated compounds were established by analysis of spectroscopic data, X-ray diffraction technique as well as comparison with the literature data. The cytotoxicity of all isolated compounds against a panel of cultured cancer cell lines was evaluated. Compound 4 exhibited good cytotoxicity with ED50 values ranging from 3...
October 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27788191/preparation-and-response-to-the-2014-ebola-virus-disease-epidemic-in-nigeria-the-experience-of-a-tertiary-hospital-in-nigeria
#9
Dimie Ogoina, Abisoye Sunday Oyeyemi, Okubusa Ayah, Austin Onabor A, Adugo Midia, Wisdom Tudou Olomo, Onyaye E Kunle-Olowu
INTRODUCTION: The 2014 Ebola Virus Disease (EVD) outbreak elicited global attention and challenged health systems around the world, Nigeria inclusive. We hereby report the preparation and response to the outbreak by a tertiary teaching hospital in Bayelsa State, Nigeria. METHOD: Between 4th August and 31st October 2014, we conducted a mixed cross sectional and qualitative study to ascertain the EVD-related fear, myths and misconceptions among healthcare workers (HCWs), and to evaluate the plans, activities and challenges faced by the hospital during the outbreak...
2016: PloS One
https://www.readbyqxmd.com/read/27767192/novel-natural-product-like-caged-xanthones-bearing-a-carbamate-moiety-exhibit-antitumor-potency-and-anti-angiogenesis-activity-in-vivo
#10
Xiaoli Xu, Yue Wu, Mingyang Hu, Xiang Li, Qichao Bao, Jinlei Bian, Qidong You, Xiaojin Zhang
DDO-6101, a simplified structure obtained from the Garcinia natural product (NP) gambogic acid (GA), has been previously shown to possess high cytotoxicity to a variety of human tumour cell lines. To improve its physicochemical properties and in vivo cytotoxic potency, a series of novel carbamate-bearing derivatives based on DDO-6101 was synthesized and characterized. The structural modifications revealed that the presence of a carbamate moiety was useful for obtaining comparable cytotoxicity and improved aqueous solubility and permeability...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27767059/uplc-pda-qtofms-guided-isolation-of-prenylated-xanthones-and-benzoylphloroglucinols-from-the-leaves-of-garcinia-oblongifolia-and-their-migration-inhibitory-activity
#11
Hong Zhang, Zheng Dan, Zhi-Jie Ding, Yuan-Zhi Lao, Hong-Sheng Tan, Hong-Xi Xu
A UPLC-PDA-QTOFMS-guided isolation strategy was employed to screen and track potentially new compounds from Garcinia oblongifolia. As a result, two new prenylated xanthones, oblongixanthones D and E (1-2), six new prenylated benzoylphloroglucinol derivatives, oblongifolins V-Z (3-7) and oblongifolin AA (8), as well as a known compound oblongifolin L (9), were isolated from the EtOAc-soluble fraction of an acetone extract of the leaves of Garcinia oblongifolia guided by UPLC-PDA-QTOFMS analysis. The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopic analysis and mass spectrometry...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27757272/effect-of-orlistat-alone-or-in-combination-with-garcinia-cambogia-on-visceral-adiposity-index-in-obese-patients
#12
Hayder M Al-Kuraishy, Ali I Al-Gareeb
AIM: The objective of this study was to estimate the effect of orlistat alone and in combination with Garcinia cambogia on visceral adiposity index (VAI) in obese patients. PATIENTS AND METHODS: A total of 99 obese male patients were recruited with aged range between 37 and 46 years. They were randomized into three equal groups, first group treated with orlistat 120 mg/day, second group treated with G. cambogia 166 mg/day, and third group treated with orlistat 120 mg/day plus G...
September 2016: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/27754347/nujiangexathone-a-a-novel-compound-derived-from-garcinia-nujiangensis-induces-caspase-dependent-apoptosis-in-cervical-cancer-through-the-ros-jnk-pathway
#13
Li Zhang, Si-Yuan Kong, Zhao-Qing Zheng, Xiao-Xiao Meng, Ji-Ling Feng, Hong-Sheng Tan, Yuan-Zhi Lao, Lian-Bo Xiao, Hong-Xi Xu
Nujiangexathone A (NJXA), a novel compound derived from Garcinia nujiangensis, has been demonstrated to inhibit the proliferation of several human cancer cell lines. This study is the first to demonstrate the apoptosis inductive activities of NJXA and the possible underlying mechanisms. Our results demonstrated that NJXA inhibited colony formation by HeLa and SiHa cells in a dose-dependent manner. An Annexin V-FITC/PI staining assay showed that NJXA strongly triggered apoptosis in a dose-dependent manner. Western blotting analyses showed that NJXA induced the caspase-dependent apoptosis of HeLa and SiHa cells by triggering a series of events, including changes in the levels of Bcl-2 family proteins, cytochrome c release, caspase-3 activation, and chromosome fragmentation...
October 12, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27738860/mangostanaxanthones-iii-and-iv-advanced-glycation-end-product-inhibitors-from-the-pericarp-of-garcinia-mangostana
#14
Hossam M Abdallah, Hany M El-Bassossy, Gamal A Mohamed, Ali M El-Halawany, Khalid Z Alshali, Zainy M Banjar
Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, atherosclerosis, retinopathy, neuropathy, and Alzheimer's disease. Garcinia mangostana L. (Clusiaceae) (GM) was selected owing to the ability of its polar and non-polar fractions to inhibit AGE formation...
October 13, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27714857/depigmentation-of-%C3%AE-melanocyte-stimulating-hormone-treated-melanoma-cells-by-%C3%AE-mangostin-is-mediated-by-selective-autophagy
#15
Ki Won Lee, Hyung Won Ryu, Sang-Seok Oh, Soojong Park, Hamadi Madhi, Jiyun Yoo, Ki-Hun Park, Kwang Dong Kim
Melanogenesis is a key pathway for the regulation of skin pigmentation and the development of skin-lightening/whitening drugs or cosmetics. In this study, we found that β-mangostin from seedcases of Garcinia mangostana inhibited α-melanocyte-stimulating hormone (α-MSH)-mediated melanogenesis in B16F10 melanoma cells and a three-dimensional human skin model. β-Mangostin significantly inhibited the protein level of tyrosinase induced by α-MSH in UPS (ubiquitin proteasome system)-independent and lysosome-dependent manner...
October 7, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27702395/identification-and-quantification-of-adulteration-in-garcinia-cambogia-commercial-products-by-chromatographic-and-spectrometric-methods
#16
Nargis Jamila, Ji Yeon Choi, Joon Ho Hong, Eun Yeong Nho, Naeem Khan, Cheon Ho Jo, Hyang Sook Chun, Kyong Su Kim
Species of genus Garcinia are rich sources of bioactive constituents with antimicrobial, anticancer, anti-inflammatory, hepatoprotective and anti-HIV activities. Commercial products of Garcinia cambogia are used as anti-obesity drugs with increasing market demand. Because of the high price of its products, it can be adulterated with similar lower-priced species. This study was designed to develop and validate an accurate and efficient method for the detection of any adulteration (G. indica) in G. cambogia products...
December 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27696898/estimating-genetic-structure-and-diversity-of-cyanobacterial-communities-in-atlantic-forest-phyllosphere
#17
Janaina Rigonato, Natalia Gonçalves, Ana Paula Dini Andreote, Marcio Rodrigues Lambais, Marli Fátima Fiore
Cyanobacterial communities on the phyllosphere of 4 plant species inhabiting the endangered Brazilian Atlantic Forest biome were evaluated using cultivation-independent molecular approaches. Total genomic DNA was extracted from cells detached from the surface of leaves of Euterpe edulis, Guapira opposita, Garcinia gardneriana, and Merostachys neesii sampled in 2 Brazilian Atlantic Forest locations along an elevational gradient, i.e., lowland and montane forest. The DNA fingerprinting method PCR-DGGE revealed that the cyanobacterial phyllosphere community structures were mainly influenced by the plant species; geographical location of the plant had little effect...
June 20, 2016: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/27686270/three-indigenous-plants-used-in-anti-cancer-remedies-garcinia-kola-heckel-stem-bark-uvaria-chamae-p-beauv-root-and-olax-subscorpioidea-oliv-root-show-analgesic-and-anti-inflammatory-activities-in-animal-models
#18
Temidayo D Popoola, Olufunsho Awodele, Adeola Omisanya, Nkechinyerem Obi, Chioma Umezinwa, Amos A Fatokun
ETHNOPHARMACOLOGICAL RELEVANCE: Phytochemicals with anti-oxidative and anti-inflammatory properties are known to inhibit tumour initiation, promotion and progression. Hence, there is an increasingly-convincing rationale for employing remedies containing those phytochemicals in the treatment of cancers and also as analgesic and anti-inflammatory adjuvants in therapy. The plants Garcinia kola Heckel (Clusiaceae), stem bark; Uvaria chamae P. Beauv. (Annonaceae), root; and Olax subscorpioidea Oliv...
September 26, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27671827/garcinol-and-its-role-in-chronic-diseases
#19
Amit K Behera, Mahadeva M Swamy, Nagashayana Natesh, Tapas K Kundu
The various bioactive compounds isolated from leaves and fruits of Garcinia sps plants, have been characterized and experimentally demonstrated to be anti-oxidant, anti-inflammatory and anti-cancer in nature. Garcinol, a polyisoprenylated benzophenone, obtained from plant Garcinia indica has been found to be an effective inhibitor of several key regulatory pathways (e.g., NF-kB, STAT3 etc.) in cancer cells, thereby being able to control malignant growth of solid tumours in vivo. Despite its high potential as an anti-neoplastic modulator of several cancer types such as head and neck cancer, breast cancer, hepatocellular carcinoma, prostate cancer, colon cancer etc...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27671824/gambogic-acid-and-its-role-in-chronic-diseases
#20
Manoj K Pandey, Deepkamal Karelia, Shantu G Amin
Kokum, a spice derived from the fruit of the Garcinia hanburyi tree, is traditionally used in Ayurvedic medicines to facilitate digestion and to treat sores, dermatitis, diarrhoea, dysentery, and ear infection. One of the major active components of kokum is gambogic acid, also known as guttic acid, guttatic acid, beta-guttilactone, and beta-guttiferin. Gambogic acid's anti-proliferative, anti-bacterial; antioxidant and anti-inflammatory effects result from its modulation of numerous cell-signaling intermediates...
2016: Advances in Experimental Medicine and Biology
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