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https://www.readbyqxmd.com/read/29876463/esi-lc-ms-based-metabolomics-data-of-mangosteen-garcinia-mangostana-linn-fruit-pericarp-aril-and-seed-at-different-ripening-stages
#1
Siti Farah Mamat, Kamalrul Azlan Azizan, Syarul Nataqain Baharum, Normah Mohd Noor, Wan Mohd Aizat
Fruit ripening is a complex phenomenon involving a series of biochemical, physiological and organoleptic changes. Ripening process in mangosteen ( Garcinia mangostana Linn.) is unique of which the fruit will only ripen properly if harvested during its middle stage (emergence of purple/pink colour) but not earlier (green stage). The knowledge on the molecular mechanism and regulation behind this phenomenon is still limited. Hence, electrospray ionization liquid chromatography mass spectrometry (ESI-LC-MS) based metabolomics analysis was applied to determine the metabolome of mangosteen ripening...
April 2018: Data in Brief
https://www.readbyqxmd.com/read/29847737/kolaviron-attenuates-diclofenac-induced-nephrotoxicity-in-male-wistar-rats
#2
Quadri Kunle Alabi, Rufus Ojo Akomolafe, Modinat Adebukola Adefisayo, Olaoluwa Sesan Olukiran, Aliyat Olajumoke Nafiu, Micheal K Fasanya, Ayodele Oladele
The beneficial effects of kolaviron, a natural biflavonoid from the seeds of Garcinia kola, have been attributed to its antioxidant and anti-inflammatory activities. This study was designed to investigate the renoprotective effect of kolaviron in rat model of diclofenac (DFC)-induced acute renal failure. Thirty-five male Wistar rats were divided into seven groups of five rats each as follows: a control group that received propylene glycol orally and treatment groups that received diclofenac, diclofenac followed by kolaviron at three different doses and kolaviron only...
May 30, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29844801/chrysanthemum-indicum-l-ethanol-extract-reduces-high-fat-diet-induced-obesity-in-mice
#3
Ji-Yun Cha, Sarmila Nepali, Hoon-Yeon Lee, Sung-Woo Hwang, Sang-Yong Choi, Jeong-Mo Yeon, Bong-Joon Song, Dae-Ki Kim, Young-Mi Lee
The present study was undertaken to investigate the mechanism behind the anti-obesity effect of the 50% ethanol extract of Chrysanthemum indicum L. flowers (CIEE) in a mouse model of high-fat diet (HFD)-induced obesity. Male C57BL/6J mice (six mice in each group) were administered CIEE (8, 40 and 200 mg/kg) for 6 weeks while being fed with a HFD. Garcinia cambogia (GC) was used as the positive control and was administered in the same manner as CIEE. Results demonstrated that oral administration of CIEE significantly reduced body weight, epididymal white adipose tissue (EWAT), liver weight and serum levels of total cholesterol and triglyceride (P<0...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29802521/acute-liver-injury-following-garcinia-cambogia-weight-loss-supplementation-case-series-and-literature-review
#4
Giada Crescioli, Niccolò Lombardi, Alessandra Bettiol, Ettore Marconi, Filippo Risaliti, Michele Bertoni, Francesca Menniti Ippolito, Valentina Maggini, Eugenia Gallo, Fabio Firenzuoli, Alfredo Vannacci
Herbal weight-loss supplements are sold as self-medication products, and are often used under the misconception that their natural origin guarantees their safety. Food supplements are not required to provide any benefit/risk profile evaluation before marketing; however, possible risks associated with use of herbal extracts in food supplements are becoming more and more documented in the literature. Some herbs are listed as the leading cause of herb-induced liver injury, with a severe or potentially lethal clinical course, and unpredictable herb-drug interactions...
May 25, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29790527/protective-activity-of-tovophyllin-a-a-xanthone-isolated-from-garcinia-mangostana-pericarps-against-acetaminophen-induced-liver-damage-role-of-nrf2-activation
#5
Sabrin R M Ibrahim, Dina S El-Agamy, Hossam M Abdallah, Nishat Ahmed, Mohamed A Elkablawy, Gamal A Mohamed
Garcinia mangostana L. (GM, family Guttiferae) is one of the most widely recognized tropical fruits. GM is a wealthy pool of xanthones that exhibit a wide range of bioactivities. Tovophyllin A (TA) separated from GM pericarps was tested for its efficacy to ameliorate acetaminophen (APAP)-induced liver injury. Mice were injected with a single dose of APAP with or without TA pretreatment. The protective effects of TA against APAP-induced liver damage were evident through amelioration of serum indices of hepatotoxicity and improvement of hepatic histopathologic lesions...
May 23, 2018: Food & Function
https://www.readbyqxmd.com/read/29772703/alpha-mangostin-improves-insulin-secretion-and-protects-ins-1-cells-from-streptozotocin-induced-damage
#6
Dahae Lee, Young-Mi Kim, Kiwon Jung, Young-Won Chin, Ki Sung Kang
Alpha (α)-mangostin, a yellow crystalline powder with a xanthone core structure, is isolated from mangosteen ( Garcinia mangostana ), which is a tropical fruit of great nutritional value. The aim of the present study was to investigate the anti-diabetic effects of α-mangostin and to elucidate the molecular mechanisms underlying its effect on pancreatic beta (β)-cell dysfunction. To assess the effects of α-mangostin on insulin production, rat pancreatic INS-1 cells were treated with non-toxic doses of α-mangostin (1⁻10 μM) and its impact on insulin signaling was examined by Western blotting...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29764763/direct-recovery-of-mangostins-from-garcinia-mangostana-pericarps-using-cellulase-assisted-aqueous-micellar-biphasic-system-with-recyclable-surfactant
#7
Hui-Suan Ng, Grace Yin Tze Tan, Ka-Heng Lee, Wolfgang Zimmermann, Hip Seng Yim, John Chi-Wei Lan
The α- and γ-mangostins from Garcinia mangostana pericarps (GMP) exhibit antioxidant, anti-bacterial, anti-inflammatory and anti-tumor properties. The extraction yields α- and γ-mangostins are often limited by the presence of the GMP cell walls. Therefore, the extraction and recovery of mangostins from GMP with an Aspergillus niger cellulase-assisted aqueous micellar biphasic system (CA-AMBS) was developed for enhanced yield of mangostins. Effects of the concentration of cellulase, the incubation time and the temperature of the system on the recovery of mangostins were investigated...
May 12, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29738915/cytotoxic-garcimultiflorones-k-q-lavandulyl-benzophenones-from-garcinia-multiflora-branches
#8
Zhao-Quan Wang, Xing-Yu Li, Dong-Bao Hu, Chun-Lin Long
Seven undescribed lavandulyl benzophenones garcimultiflorones K-Q, and fourteen known compounds were isolated from the CHCl3 soluble fraction of 95% EtOH extract of Garcinia multiflora branches. Their structures and absolute configurations were determined by spectroscopic techniques including NMR spectroscopy, MS analysis, and ECD calculations. Seven isolated compounds expect for garcimultiflorone L and garcimultiflorone O exhibited cytotoxic activities in vitro against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7, and SW480)...
May 5, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29736386/evaluation-of-antinociceptive-antihyperglycemic-and-membrane-stabilizing-activities-of-garcinia-lancifolia-roxb
#9
Antara Ghosh, Sujan Banik, Mohammad Nurul Amin, Jamiuddin Ahmed
This study was undertaken to examine the antinociceptive, antihyperglycemic, and membrane stabilizing activity with phytochemical screening of methanolic extract of Garcinia lanceifolia whole plant. The extracts were subjected to in-vivo antinociceptive, antihyperglycemic activity in laboratory animals and in-vitro membrane stabilizing activity. In peripheral antinociceptive activity, G. lanceifolia (400 and 200 mg/kg) exhibited significant (P < 0.001) inhibition of writhing with 59.15% and 49.30% respectively comparable to standard Diclofenac (54...
April 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29734675/selected-physiological-effects-of-a-garcinia-gummi-gutta-extract-in-rats-fed-with-different-hypercaloric-diets
#10
Carolina Guillén-Enríquez, Veronica López-Teros, Ubicelio Martín-Orozco, José A López-Díaz, Julio Del Hierro-Ochoa, Arnulfo Ramos-Jiménez, Humberto Astiazarán-García, Nina Del Rocío Martínez-Ruiz, Abraham Wall-Medrano
Garcinia gummi-gutta (GGG) rind extract is effective for reducing appetite, body weight and adiposity of obese rodents fed high-fat (HF), high-sugar (HS) or high fat/sugar (HFS)-based diets, but these effects have not been simultaneously evaluated. Thirty obese (~425 g) male Wistar rats were fed for eleven weeks with six hypercaloric diets (4.1 kcal/g; five rats/diet) non-supplemented (HF, HS, HFS), or supplemented (HF+, HS+, HFS+) with GGG extract (5.9%), while rats from the control group (375 g) were fed a normocaloric diet (3...
May 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29730092/kolaviron-protects-the-brain-in-cuprizone-induced-model-of-experimental-multiple-sclerosis-via-enhancement-of-intrinsic-antioxidant-mechanisms-possible-therapeutic-applications
#11
Gabriel Olaiya Omotoso, Ileje Inelo Ukwubile, Leviticus Arietarhire, Fatima Sulaimon, Ismail Temitayo Gbadamosi
Multiple sclerosis is a demyelinating condition of the central nervous system which commonly affects young adults. Kolaviron, a biflavonoid isolate of Garcinia kola, has been used in experimental studies which explored its anti-oxidative, anti-inflammatory and anti-genotoxic properties. This work was aimed at unraveling the possible ameliorative effect of kolaviron on cuprizone-induced demyelination in the prefrontal cortices of Wistar rats. A total of 28 adult male Wistar rats were divided into four groups A-D...
April 27, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29721342/hepatotoxicity-associated-with-use-of-the-weight-loss-supplement-garcinia-cambogia-a-case-report-and-review-of-the-literature
#12
Jiten P Kothadia, Monica Kaminski, Hrishikesh Samant, Marco Olivera-Martinez
The use of herbal and dietary supplements for weight loss is becoming increasingly common as obesity is becoming major health problem in the United States. Despite the popularity of these natural supplements, there are no guidelines for their therapeutic doses and their safety is always a concern. Garcinia cambogia extract with its active ingredient "hydroxycitric acid" is a component of many weight loss regimens. It suppresses fatty acid biosynthesis and decreases appetite. However, its prolonged use in weight maintenance is unknown...
2018: Case Reports in Hepatology
https://www.readbyqxmd.com/read/29720835/combination-of-garcinia-cambogia-extract-and-pear-pomace-extract-additively-suppresses-adipogenesis-and-enhances-lipolysis-in-3t3-l1-cells
#13
Kushal Sharma, Siwon Kang, Dalseong Gong, Sung-Hwa Oh, Eun-Young Park, Min-Ho Oak, Eunyoung Yi
Background: Inhibition of adipogenesis has been a therapeutic target for reducing obesity and obesity-related disorders such as diabetes, hypertension, atherosclerosis, and cancer. For decades, anti-adipogenic potential of many herbal extracts has been investigated. One example is Garcinia cambogia extract (GE) containing (-)-hydroxycitric acid as an active ingredient. GE is currently marketed as a weight loss supplement, used alone or with other ingredients. Pear pomace extract (PE), another natural product, has been also shown to have anti-adipogenic activity in a recent report...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720829/biochemical-evidence-for-the-antitumor-potential-of-garcinia-mangostana-linn-on-diethylnitrosamine-induced-hepatic-carcinoma
#14
V Vishnu Priya, Mallika Jainu, Surapaneni Krishna Mohan
Background: Garcinia mangostana is extensively used in most of the Indian herbal pharmaceuticals and nutraceuticals. Objective: The objective of this study was to elucidate the underlying biochemical protective mechanism of G. Mangostana Linn. fruit extract (GME) in deterioration of diethylnitrosamine (DEN)-induced hepatic carcinoma (HCC) in rats. Materials and Methods: The cancer was induced using DEN to the experimental rats and treated with GME (200, 400, and 600 mg/kg) to find its anticancer property...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29677543/garcinia-morella-fruit-a-promising-source-of-antioxidant-and-anti-inflammatory-agents-induces-breast-cancer-cell-death-via-triggering-apoptotic-pathway
#15
Bhaswati Choudhury, Raghuram Kandimalla, R Elancheran, Rupjyoti Bharali, Jibon Kotoky
A rapid rise in cancer cases worldwide, especially breast cancer in females, instigates the need for more effective and less side effect causing drugs from natural origin. Thereby, in the present study, Garcinia morella fruit was investigated for antioxidant, anti-inflammatory and anti-breast cancer activity. Preliminary antioxidant and anticancer evaluation of different fractions and crude methanol extract of G. morella fruit suggested chloroform fraction as the bioactive fraction. Time course analysis (by 24 h, 48 h and 72 h) of the bioactive fraction (1...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29655982/polyprenylated-polycyclic-acylphloroglucinol-angiogenesis-inhibitor-from-garcinia-multiflora
#16
Lin-Yang Cheng, Chun-Lin Chen, Yueh-Hsiung Kuo, Tsung-Hsien Chang, I-Wei Lin, Shih-Wei Wang, Mei-Ing Chung, Jih-Jung Chen
A new polyprenylated polycyclic acylphloroglucinol, garcimultiflorone K (1), has been isolated from the stems of Garcinia multiflora, together with two known compounds, garcimultiflorone A (2) and garcimultiflorone B (3). The structure of new compound 1 was determined through spectroscopic methods including 1D and 2D NMR and MS analyses. The anti-angiogenic and anti-cancer effects of compounds 1-3 were evaluated in human endothelial progenitor cells (EPCs) and cancer cells. Of these, garcimultiflorone K (1) displayed the most potent anti-angiogenic property by suppressing cell growth and tube formation of EPCs...
June 1, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29620273/p38-inhibitor-inhibits-the-apoptosis-of-cowanin-treated-human-colorectal-adenocarcinoma-cells
#17
Nittiya Chowchaikong, Sirinun Nilwarangkoon, Surat Laphookhieo, Chantra Tanunyutthawongse, Ramida Watanapokasin
Colorectal cancer, which is the third most common type of cancer diagnosed in both men and women, is the leading cause of cancer-related deaths worldwide. Cowanin is a pure compound extracted from Garcinia cowa Roxb., a tree species present in Thailand, Malaysia and Myanmar. The crude extract has been demonstrated to have antitumor activity, inflammation induction, antibacterial activity, anti-inflammatory activity and antimalarial activity. In the present study, the effects of cowanin on apoptosis induction and on the apoptosis-related and mitogen-activated protein kinase (MAPK) pathways were investigated in the LoVo human colorectal cancer cell line...
June 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29615704/virtual-screening-docking-admet-and-system-pharmacology-studies-on-garcinia-caged-xanthone-derivatives-for-anticancer-activity
#18
Sarfaraz Alam, Feroz Khan
Caged xanthones are bioactive compounds mainly derived from the Garcinia genus. In this study, a structure-activity relationship (SAR) of caged xanthones and their derivatives for anticancer activity against different cancer cell lines such as A549, HepG2 and U251 were developed through quantitative (Q)-SAR modeling approach. The regression coefficient (r2 ), internal cross-validation regression coefficient (q2 ) and external cross-validation regression coefficient (pred_r2 ) of derived QSAR models were 0.87, 0...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29600757/preclinical-hepatoprotective-effect-of-herbalism-against-ethanol-induced-hepatotoxicity-a-review
#19
Hina Firdous, Talib Hussain, Monika Singh, Syed Mohd Danish Rizvi, Afrasim Moin, Mohammad A Kamal
Liver ailments including alcoholic liver disease (ALD), still remain the main reason for morbidity & mortality worldwide. In fact, ALD is a multifactorial disease with complex pathophysiology which is linked to several types of liver damages including steatohepatitis, fibrosis and cirrhosis. This review emphasizes on 30 herbal medicinal plants with their extracts studied for protective effect against ALD and current scientific evidence of ALD cure by thirty Indian Materia Medica including Tilia Platyphyllos, Amomum subulatum, Carica papaya, Pogostemon patchouli, Commelina benghalensis, Bacopamonnieri, Pecan nut, Allium cepa, Beta Vulgaris, Adina cordifolia, Ocimum gratissimum, Vernonia amygdalina, Sida veronicaefolia, Chenopodium album, Korean red ginseng, Elephantopus scaber, Tecomella undulata, Prunus armeniaca, Sea tangle (Laminaria japonica), Emblica officinalis, Saccharum officinarum, Cocculus hirsutus, Cassia roxburghii, Zhi-Zi-Da-Huang, Phyllanthus amarus, Aegle marmelos, Agrimonia eupatoria, Flaveria trinervia, Curcuma longa and Garcinia indica...
March 30, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29599482/the-notch-inhibitor-cowanin-accelerates-nicastrin-degradation
#20
Midori A Arai, Ryuta Akamine, Anna Tsuchiya, Tatsuro Yoneyama, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi
Aberrant activation of Notch signaling contributes to the pathogenesis of several different types of cancer, and Notch pathway inhibitors may have significant therapeutic potential. Using a unique cell-based assay system, we isolated twelve compounds, including one new natural product from Garcinia speciosa, that inhibit the Notch signaling pathway. HES1 and HES5 are target genes of the Notch cascade, and compound 2, referred to as cowanin, decreased the protein levels of HES1 and HES5 in assay cells. Furthermore, cowanin (2) showed potent cytotoxicity against human leukemic HPB-ALL cells...
March 29, 2018: Scientific Reports
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