keyword
MENU ▼
Read by QxMD icon Read
search

garcinia

keyword
https://www.readbyqxmd.com/read/29207025/anti-obesity-effects-of-pectinase-and-cellulase-enzyme%C3%A2-treated-ecklonia%C3%A2-cava-extract-in-high%C3%A2-fat-diet%C3%A2-fed-c57bl-6n-mice
#1
In-Hye Kim, Jung-Wook Choi, Min-Kyeong Lee, Chang-Ju Kwon, Taek-Jeong Nam
The present study investigated the anti‑obesity effects of enzyme‑treated Ecklonia cava extract (EEc) in C57BL/6N mice with high‑fat diet (HFD)‑induced obesity. The EEc was separated and purified with the digestive enzymes pectinase (Rapidase X‑Press L) and cellulase (Rohament CL) and its effects on the progression of HFD‑induced obesity were examined over 10 weeks. The mice were divided into 6 groups (n=10/group) as follows: Normal diet group, HFD group, mice fed a HFD with 25 mg/kg/day Garcinia cambogia extract and mice fed a HFD with 5, 25 or 150 mg/kg/day EEc (EHD groups)...
November 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29195484/targeted-delivery-of-garcinia-glycosides-by-reconstituted-high-density-lipoprotein-nano-complexes
#2
Chang Liu, Zijun Zhou, Ye Chen, Ju Liu, Yang Wang, Hongsheng Liu
Scavenger receptor class B type 1 (SR-B1) is over-expressed in tumor cells where it mediates the uptake of drug payload of reconstituted high density lipoprotein (rHDL) via the process of reverse cholesterol transport. In this study, rHDL was prepared to determine its function as a drug delivery carrier for targeting hepatocellular carcinoma by incorporating the anti-tumor drug garcinia glycosides into rHDL to yield rHDL/GG nano-complexes. Structural analysis indicated that the rHDL/GG nano-complex was similar to HDL in size...
December 1, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29192501/all-organic-label-like-copper-ii-ions-fluorescent-film-sensors-with-high-sensitivity-and-stretchability
#3
Mengjer Wu, Hsiu-Hao Hu, Chen-Zih Siao, Yu-Ming Liao, Jyun-Han Chen, Ming-Yang Li, Tai-Yuan Lin, Yang-Fang Chen
Deep learning and analysis of heavy metal concentration are very crucial to our life, for it plays an essential role in both environmental and human health. In this paper, we developed a new Cu (II) ions sensor made by all organic material with bending and stretching properties. The new sensor consists of chlorophyll-a extracted from fresh leaves of Common Garcinia, plant fiber and with the use of PDMS as a substrate. Fluorescence spectra study shows that chlorophyll-a is significantly much more sensitive to Cu (II) ions than any other heavy metal ions and the device sensitivity outperforms all the Cu (II) ions sensors ever reported...
December 1, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29188226/data-on-rna-seq-analysis-of-garcinia-mangostana-l-seed-development
#4
Othman Mazlan, Azhani Abdul-Rahman, Hoe-Han Goh, Wan Mohd Aizat, Normah Mohd Noor
Mangosteen (Garcinia mangostana L.) has exceptional potential for commercial and pharmaceutical applications due to its delicious fruit and medicinal properties. Nevertheless, the molecular mechanism of mangosteen seed development is poorly understood. In this study, we performed transcriptomic analysis of four seed developmental stages; eight, ten, twelve and fourteen weeks after anthesis. Illumina HiSeq™ 4000 sequencer was used to generate raw data of approximately 68 Gb in size. From 451,495,326 raw reads, 406,143,756 clean reads were obtained...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29186708/isogambogenic-acid-inhibits-the-growth-of-glioma-through-activation-of-the-ampk-mtor-pathway
#5
Wenyang Zhao, Fei Peng, Mengting Shu, Huailei Liu, Xu Hou, Xiaoxiong Wang, Junyi Ye, Boxian Zhao, Kaikai Wang, Chen Zhong, Linmeng Xue, Ming Gao, Yaohua Liu, Shiguang Zhao
BACKGROUND/AIMS: Glioma is the most devastating cancer in the brain and has a poor prognosis in adults. Therefore, there is a critical need for novel therapeutic strategies for the management of glioma patients. Isogambogenic acid, an active compound extracted from the Chinese herb Garcinia hanburyi, induces autophagic cell death. METHODS: Cell viability was detected with MTT assays. Cell proliferation was assessed using the colony formation assay. Morphological changes associated with autophagy and apoptosis were tested by TEM and Hoechst staining, respectively...
November 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29176590/nanocarrier-mediated-delivery-of-%C3%AE-mangostin-for-non-surgical-castration-of-male-animals
#6
Jakarwan Yostawonkul, Suvimol Surassmo, Katawut Namdee, Mattaka Khongkow, Chatwalee Boonthum, Sasithon Pagseesing, Nattika Saengkrit, Uracha Rungsardthong Ruktanonchai, Kaywalee Chatdarong, Suppawiwat Ponglowhapan, Teerapong Yata
The overpopulation of abandoned and stray companion animals has become a global crisis. The main purpose of this study was to develop a novel nanomedicine-based antifertility compound for non-surgical castration of male animals. Mangosteen (Garcinia mangostana L) pericarp extract has been shown to exhibit anti-fertility property. α-mangostin (AM)-loaded nanostructured lipid carrier (AM-NLC) was developed to improve male germ cell apoptosis. This study was conducted to investigate physicochemical properties of AM-NLC and determine the biological effects of AM-NLC on spermatogonia cells and testicular explants obtained from castrated testes...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138827/gambogic-acid-inhibits-spinal-cord-injury-and-inflammation-through-suppressing-the-p38-and-akt-signaling-pathways
#7
Qiao Fu, Chaojian Li, Lehua Yu
Gamboge is the dry resin secreted by Garcinia hanburyi Hook.f, with the function of promoting blood circulation, detoxification, hemostasis and killing insects, used for the treatment of cancer, brain edema and other diseases. Gambogic acid is the main effective constituent of Gamboge. The present study investigated the protective effects of gambogic acid on spinal cord injury (SCI) and its anti‑inflammatory mechanism in an SCI model in vivo. Basso, Beattie and Bresnahan (BBB) testing was used to detect the protective effects of gambogic acid on nerve function of SCI rats...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29132213/a-novel-xanthone-dimer-derivative-with-antibacterial-activity-isolated-from-the-bark-of-garcinia-mangostana
#8
Weiyi Wang, Yanyan Liao, Xiaomei Huang, Chao Tang, Peng Cai
A novel xanthone dimer derivative, garmoxanthone (1), together with 10 known compounds (2-11), were isolated from bark of Garcinia mangostana. Their structures were established through spectroscopic methods. Garmoxanthone exhibited strong inhibitory activities against MRSA ATCC 43300 and MRSA CGMCC 1.12409 (with MIC values of both 3.9 μg/mL) and moderate activities against tested strains of Vibrio (with MIC values ranging from 15.6 to 31.2 μg/mL). Garmoxanthone is a unique xanthone dimer with linkage of a fused 5/6 ring system and its absolute configuration was elucidated on the basis of experimental and calculated electronic circular dichroism...
November 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29128163/depsidone-and-xanthones-from-garcinia-xanthochymus-with-hypoglycemic-activity-and-the-mechanism-of-promoting-glucose-uptake-in-l6-myotubes
#9
Yunfang Li, Ping Zhao, Yu Chen, Yanze Fu, Kuan Shi, Liu Liu, Hui Liu, Mingrui Xiong, Qing-Hua Liu, Guangzhong Yang, Yuxiu Xiao
Garcinia xanthochymus is a widely used folk medicine in southwestern China. Previous studies indicated it possesses potential anti-diabetic activities both in vitro (Fu et al., 2014; Nguyen et al., 2017) and in vivo (Shivanand et al., 2017). To discover bioactive ingredients from it and unveil their mechanism of action against diabetes, the present study was designed to isolate constituents from extract of G. xanthochymus, determine their structures, screen their activities and investigate mechanism of action of the active substances...
November 8, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29116938/mangostanaxanthone-vii-a-new-cytotoxic-xanthone-from-garcinia-mangostana
#10
Sabrin R M Ibrahim, Gamal A Mohamed, Mahmoud A Elfaky, Mohamed F Zayed, Amal A El-Kholy, Osama H Abdelmageed, Samir A Ross
Garcinia mangostana L. (the queen of fruits, mangosteen, family Guttiferae) is a wealthy source of xanthones. The CHCl3 soluble fraction of the air-dried pericarps of G. mangostana provided a new xanthone: mangostanaxanthone VII (5), along with four known xanthones: mangostanaxanthones I (1) and II (2), gartanin (3) and γ-mangostin (4). The structural verification of these metabolites was achieved by different spectral techniques, including UV, IR, 1D and 2D NMR and HRESIMS. The new metabolite was assessed for cytotoxic potential, using sulforhodamine B (SRB) assay towards the A549 and MCF-7 cancer cell lines...
November 8, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/29112891/a-novel-research-model-for-evaluating-sunscreen-protection-in-the-uv-a1
#11
Sônia Aparecida Figueiredo, Dayane Cristina de Moraes, Fernanda Maria Pinto Vilela, Amanda Natalina de Faria, Marcelo Henrique Dos Santos, Maria José Vieira Fonseca
The use of a broad spectrum sunscreen is considered one of the main and most popular measures for preventing the damaging effects of ultraviolet radiation (UVR) on the skin. In this study we have developed a novel in vitro method to assess sunscreens efficacy to protect calcineurin enzyme activity, a skin cell marker. The photoprotective efficacy of sunscreen products was assessed by measuring the UV-A1 radiation-induced depletion of calcineurin (Cn) enzyme activity in primary neonatal human dermal fibroblast (HDFn) cell lysates...
October 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29101602/garcinia-mangostana-linn-displays-antidepressant-like-and-pro-cognitive-effects-in-a-genetic-animal-model-of-depression-a-bio-behavioral-study-in-the-flinders-sensitive-line-rat
#12
Inge Oberholzer, Marisa Möller, Brendan Holland, Olivia M Dean, Michael Berk, Brian H Harvey
There is abundant evidence for both disorganized redox balance and cognitive deficits in major depressive disorder (MDD). Garcinia mangostana Linn (GM) has anti-oxidant activity. We studied the antidepressant-like and pro-cognitive effects of raw GM rind in Flinders Sensitive Line (FSL) rats, a genetic model of depression, following acute and chronic treatment compared to a reference antidepressant, imipramine (IMI). The chemical composition of the GM extract was analysed for levels of α- and γ-mangostin...
November 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29077076/-click-chemistry-synthesis-of-novel-natural-product-like-caged-xanthones-bearing-a-1-2-3-triazole-moiety-with-improved-druglike-properties-as-orally-active-antitumor-agents
#13
Xiang Li, Yue Wu, Yanyan Wang, Qidong You, Xiaojin Zhang
DDO-6101, a natural-product-like caged xanthone discovered previously in our laboratory based on the pharmacophoric scaffold of the Garcinia natural product gambogic acid (GA), shows potent cytotoxicity in vitro, but poor efficacy in vivo due to its poor druglike properties. In order to improve the druglike properties and in vivo antitumor potency, a novel series of ten triazole-bearing caged xanthone derivatives of DDO-6101 has been efficiently synthesized by 'click chemistry' and evaluated for their in vitro antitumor activity and druglike properties...
October 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29066885/asymmetric-dumbbell-shaped-silver-nanoparticles-and-spherical-gold-nanoparticles-green-synthesized-by-mangosteen-garcinia-mangostana-pericarp-waste-extracts
#14
Ji Su Park, Eun-Young Ahn, Youmie Park
Mangosteen (Garcinia mangostana) pericarp waste extract was used to synthesize gold and silver nanoparticles by a green strategy. The extract was both a reducing and stabilizing agent during synthesis. Phytochemical screening of the extract was conducted to obtain information regarding the presence/absence of primary and secondary metabolites in the extract. The in vitro antioxidant activity results demonstrated that the extract had excellent antioxidant activity, which was comparable to a standard (butylated hydroxy toluene)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29051716/assessment-of-the-effects-of-graded-doses-of-polyphenolic-rich-fraction-of-garcinia-kola-seeds-on-pituitary-testicular-axis-of-male-wistar-rats
#15
Mosunmola Busayo Omotola, Isaac O Adeosun, Efere M Obuotor, Rufus O Akomolafe, Olugbenga A Ayannuga
This study evaluated the ameliorative and prophylactic effects of 2 different doses of polyphenolic-rich fraction of Garcinia kola (PPRFGk) seeds on the histology and hormones of pituitary-testicular axis of male Wistar rats. Thirty-five male Wistar rats (150-200 g) were divided into 7 groups of 5 rats each. Groups I and II were given distilled water (0.5 mL/day) for 8 days followed by propylene glycol (0.2 mL/d) and 600 mg/kg of PPRFGk, respectively, for 21 days. Group III received sodium arsenate (8 days), left untreated for 21 days...
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29039600/synergism-between-%C3%AE-mangostin-and-trail-induces-apoptosis-in-squamous-cell-carcinoma-of-the-oral-cavity-through-the-mitochondrial-pathway
#16
Masakatsu Fukuda, Hide Sakashita, Hiroyasu Hayashi, Junya Shiono, Genki Miyake, Yusuke Komine, Fuyoko Taira, Hideaki Sakashita
Mangosteen (Garcinia mangostana) is a tree found in South-East Asia and the pericarp of its fruit has been used in folk medicine for the treatment of many human illnesses. Mangosteen fruit rinds contain a high concentration of xanthone, which is a type of polyphenol. One type of xanthone, α-mangostin, has been reported to exert chemopreventive effects against chemically-induced colon cancer through the decrease of c-Myc expression, suppressing tumor growth in a mouse model of mammary cancer. A recent study demonstrated the inhibitive effect of α-mangostin on the growth of prostate cancer...
October 12, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039482/protective-effects-of-compounds-from-garcinia-mangostana-l-mangosteen-against-uvb-damage-in-hacat-cells-and-hairless-mice
#17
A-Rang Im, Young-Mi Kim, Young-Won Chin, Sungwook Chae
Ultraviolet B (UVB) radiation causes alterations in the skin, such as epidermal thickening, wrinkle formation and inflammation. Therefore, preventing UVB-induced skin damage can promote general health among the human population. Garcinia mangostana L. (mangosteen) is a fruit that has become a popular botanical dietary supplement because of its perceived role in promoting overall health. The present study investigated the photoprotective effects of α-, β-, γ-mangostins and gartanin against UVB radiation using the HaCaT immortalized human keratinocyte cell line as an in vitro model and hairless mice as an in vivo model...
October 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29031558/resolution-and-identification-of-scalemic-caged-xanthones-from-the-leaf-extract-of-garcinia-propinqua-having-potent-cytotoxicities-against-colon-cancer-cells
#18
Teerayut Sriyatep, Cholpisut Tantapakul, Raymond J Andersen, Brian O Patrick, Stephen G Pyne, Chatchai Muanprasat, Sawinee Seemakhan, Suparerk Borwornpinyo, Surat Laphookhieo
A new scalemic 8,8a-dihydro caged xanthone (1) was isolated from the leaf extract of Garcinia propinqua. Five other known natural products, the three caged xanthones (2, 5 and 6) and the two neocaged xanthones, (3 and 4) were also isolated as scalemic mixtures. Their structures were characterized by spectroscopic methods. The enantiomeric ratios (er) of compounds 1-6 ranged from 1:0.7 to 1:0.9. These compounds were also resolved by semipreparative chiral HPLC. The absolute configurations of (+)-2 and (+)-3 were determined by single-crystal X-ray diffraction analysis using Cu Kα radiation while the absolute configurations of the other compounds were determined by comparisons of their ECD spectra...
October 12, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29031401/screening-of-some-lesser-known-tree-borne-oilseed-plants-from-north-east-india-for-their-oil-content-and-major-fatty-acid-components
#19
Bithika Chaliha, Lipika Lahkar, Anjali Doley, Rumi Kotoky, Siddhartha P Saikia, Subhan C Nath
Forest of North-East India is rich in a variety of tree borne oilseeds and there were no serious efforts to exploit the less known oilseeds of the forest origin. Considering the vast plant wealth and with an objective to explore these untapped potentialities of oilseed resources of NE India, a research program was undertaken. The present communication is based on the investigation of seeds of 14 lesser known plant species for fats and oils. The screened plant species exhibited oil yield ranging from 4.71% to 48...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29019929/chemical-and-biological-research-on-herbal-medicines-rich-in-xanthones
#20
REVIEW
Jingya Ruan, Chang Zheng, Yanxia Liu, Lu Qu, Haiyang Yu, Lifeng Han, Yi Zhang, Tao Wang
Xanthones, as some of the most active components and widely distributed in various herb medicines, have drawn more and more attention in recent years. So far, 168 species of herbal plants belong to 58 genera, 24 families have been reported to contain xanthones. Among them, Calophyllum, Cratoxylum, Cudrania, Garcinia, Gentiana, Hypericum and Swertia genera are plant resources with great development prospect. This paper summarizes the plant resources, bioactivity and the structure-activity relationships (SARs) of xanthones from references published over the last few decades, which may be useful for new drug research and development on xanthones...
October 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
keyword
keyword
46900
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"