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https://www.readbyqxmd.com/read/30221804/dependence-of-c-fos-expression-on-amplitude-of-high-frequency-spinal-cord-stimulation-in-a-rodent-model
#1
Shiying Li, Feng Ye, Jay P Farber, Bengt Linderoth, Tianhe Zhang, Jianwen Wendy Gu, Michael Moffitt, Kennon Garrett, Jiande Chen, Robert D Foreman
OBJECTIVES: Clinical high-frequency spinal cord stimulation (hfSCS) (>250 Hz) applied at subperception amplitudes reduces leg and low back pain. This study investigates, via labeling for c-fos-a marker of neural activation, whether 500 Hz hfSCS applied at amplitudes above and below the dorsal column (DC) compound action potential (CAP) threshold excites dorsal horn neurons. MATERIALS AND METHODS: DC CAP thresholds in rats were determined by applying single biphasic pulses of SCS to T12 -T13 segments using pulse widths of 40 or 200 μsec via a ball electrode placed over the left DC and increasing amplitude until a short latency CAP was observed on the L5 DC and sciatic nerve...
September 17, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/30221656/protection-of-insulin%C3%A2-like-growth-factor-1-on-experimental-peripheral-neuropathy-in-diabetic-mice
#2
Hua Wang, Hao Zhang, Fuming Cao, Jiaping Lu, Jin Tang, Huizhi Li, Yiyun Zhang, Bo Feng, Zhaosheng Tang
The present study investigated whether insulin‑like growth factor‑1 (IGF‑1) exerts a protective effect against neuropathy in diabetic mice and its potential underlying mechanisms. Mice were divided into four groups: Db/m (control), db/db (diabetes), IGF‑1‑treated db/db and IGF‑1‑picropodophyllin (PPP)‑treated db/db. Behavioral studies were conducted using the hot plate and von Frey methods at 6 weeks of age prior to treatment. The motor nerve conduction velocity (NCV) of the sciatic nerve was measured using a neurophysiological method at 8 weeks of age...
September 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30217164/effect-of-pea-oxa-on-neuropathic-pain-and-functional-recovery-after-sciatic-nerve-crush
#3
Enrico Gugliandolo, Ramona D'amico, Marika Cordaro, Roberta Fusco, Rosalba Siracusa, Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola
BACKGROUND: Animal models of sciatic nerve injury are commonly used to study neuropathic pain as well as axon regeneration. Inflammation/immune response at the site of nerve lesion is known to be an essential trigger of the pathological changes that have a critical impact on nerve repair and regeneration; moreover, the damage to peripheral nerve can cause a loss of sensory function and produces a persistent neuropathic pain. N-Acylethanolamines (NAEs) involve a family of lipid molecules existent in animal and plant, of which is N-palmitoylethanolamide (PEA) that arouses great attention owing to its anti-inflammatory, analgesic, and neuroprotective activities...
September 14, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/30212953/bilateral-sciatic-neuropathy-with-severe-rhabdomyolysis-following-venlafaxine-overdose-a-case-report
#4
Jae Ung Ko, Hyeunsuk Seo, Goo Joo Lee, Donghwi Park
RATIONALE: Venlafaxine is an antidepressant and anxiolytic agent that functions by inhibiting central serotonin and norepinephrine reuptake, and it is a relatively recently introduced drug. In particular, overdose of venlafaxine has been reported to cause severe cardiac toxicity including ventricular tachycardia, prolongation of QT interval, and seizure or severe muscular injury. However, reports describing venlafaxine-induced rhabdomyolysis with neuropathy remain scarce. Accordingly, we report such a case involving a 49-year-old woman with bilateral sciatic neuropathy combined with rhabdomyolysis following venlafaxine overdose...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30212316/motor-nerve-conduction-velocities-of-the-median-and-sciatic-tibial-nerves-in-eight-normal-large-flying-foxes-pteropus-vampyrus
#5
Sheila Carrera-Justiz, Bonnie Gatson, Kate Bailey, James Wellehan
Electrodiagnostic testing is an integral part of the evaluation of the motor unit in many neurologic conditions. Literature about the peripheral nervous system of flying foxes ( Pteropus spp) is sparse, and reference range values for motor nerve conduction velocities in vivo have not been established in Chiropterans. The goals of this study were to determine reference range conduction velocities in flying fox for the thoracic and pelvic limb nerve. Eight Pteropus vampyrus, large flying foxes, of varying ages and gender underwent nerve conduction studies of the median nerve and sciatic-tibial nerve...
September 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/30211668/nerve-root-entrapment-with-pseudomeningocele-after-percutaneous-endoscopic-lumbar-discectomy-a-case-report
#6
Wei Shu, Haipeng Wang, Hongwei Zhu, Yongjie Li, Jiaxing Zhang, Guang Lu, Bing Ni
CONTEXT: Pseudomeningocele is a relatively uncommon postoperative complication of spine surgery. Although the condition tends to be asymptomatic and self-limiting, it may cause radicular pain and neurological defect due to herniation of the nerve root or the spinal cord. Its pathophysiology remains unclear. Only few cases with intraoperative photos have been reported. FINDING: We present a case of pseudomeningocele with nerve root entrapment after percutaneous endoscopic lumbar discectomy (PELD)...
September 13, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/30210676/the-neural-regeneration-effect-of-chitin-biological-absorbable-tubes-bridging-sciatic-nerve-defects-with-sural-nerve-grafts
#7
Zhiyong Wang, Jing Fan, Xiaomei Yang, Weiguang Zhang, Peixun Zhang, Baoguo Jiang
OBJECTIVE: To investigate the feasibility and efficacy of sural nerve grafts for repairing sciatic nerve defects using a chitin biological absorbable tube bridge. METHODS: A sciatic nerve defect model in the rat was produced, and the sural nerve, cut from the ipsilateral leg, was used as a graft to repair the defect using chitin biological absorbable tube bridges. Then the number and morphology of regenerating myelinated fibers, nerve function index, nerve conduction velocity, and motor end plate and triceps surae muscle morphology were evaluated...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/30209652/dorsal-root-ganglia-in-vivo-morphometry-and-perfusion-in-female-patients-with-fabry-disease
#8
Tim Godel, Anja Köhn, Nicole Muschol, Moritz Kronlage, Daniel Schwarz, Jennifer Kollmer, Sabine Heiland, Martin Bendszus, Victor-Felix Mautner, Philipp Bäumer
PURPOSE: To examine dorsal root ganglia and the proximal nerve segments in female patients with Fabry disease by functional and morphometric magnetic resonance neurography. METHODS: In this prospective multicenter study the lumbosacral dorsal root ganglia and proximal sciatic nerve were examined in ten female patients with Fabry disease by a standardized magnetic resonance neurography protocol at 3 T. Volumes of dorsal root ganglia L3-S2, permeability of dorsal root ganglia L5 and S1 and the spinal nerve L5 as well as the cross-sectional area of the proximal sciatic nerve were compared to 16 gender-matched healthy controls...
September 12, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30207538/remodeling-of-lumbar-motor-circuitry-remote-to-a-thoracic-spinal-cord-injury-promotes-locomotor-recovery
#9
Ying Wang, Wei Wu, Xiangbing Wu, Yan Sun, Yi P Zhang, Ling-Xiao Deng, Melissa Jane Walker, Wenrui Qu, Chen Chen, Nai-Kui Liu, Qi Han, Heqiao Dai, Lisa Be Shields, Christopher B Shields, Dale R Sengelaub, Kathryn J Jones, George M Smith, Xiao-Ming Xu
Retrogradely-transported neurotrophin signaling plays an important role in regulating neural circuit specificity. Here we investigated whether targeted delivery of neurotrophin-3 (NT-3) to lumbar motoneurons (MNs) caudal to a thoracic (T10) contusive spinal cord injury (SCI) could modulate dendritic patterning and synapse formation of the lumbar MNs. In vitro , Adeno-associated virus serotype 2 overexpressing NT-3 (AAV-NT-3) induced NT-3 expression and neurite outgrowth in cultured spinal cord neurons. In vivo , targeted delivery of AAV-NT-3 into transiently demyelinated adult mouse sciatic nerves led to the retrograde transportation of NT-3 to the lumbar MNs, significantly attenuating SCI-induced lumbar MN dendritic atrophy...
September 12, 2018: ELife
https://www.readbyqxmd.com/read/30207229/in-vitro-and-in-vivo-evaluation-of-lidocaine-hydrochloride-loaded-injectable-poly-lactic-co-glycolic-acid-implants
#10
Yongqiang Li, Xiaowei Shi
Effective postoperative pain control is essential for the recovery of surgical patients. However, long-term analgesia can seldom be achieved with the existing medications. The injectable implants prepared by biodegradable polyesters can be conveniently used during the surgery and slowly release analgesics near the operative incision during a long period. In this study, we prepared lidocaine hydrochloride (Lido-HCl)-loaded injectable poly(lactic-co-glycolic acid) (PLGA) implants for prolonged analgesia. The optimized formulation of this injectable implant sustained drug release for up to 5 days, with a cumulative release of 85...
September 12, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/30206259/three-dimensional-motion-analysis-for-comprehensive-understanding-of-gait-characteristics-after-sciatic-nerve-lesion-in-rodents
#11
Junichi Tajino, Akira Ito, Momoko Tanima, Shoki Yamaguchi, Hirotaka Iijima, Akihiro Nakahata, Wataru Kiyan, Tomoki Aoyama, Hiroshi Kuroki
Rodent models of sciatic nerve lesion are regularly used to assess functional deficits in nerves. Impaired locomotor functions induced by sciatic nerve lesion are currently evaluated with scoring systems despite their limitations. To overcome these shortcomings, which includes low sensitivity, little significance, and the representation of only marginal components of motion profiles, some additional metrics have been introduced. However, a quantitative determination of motion deficits is yet to be established...
September 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30206257/the-critical-role-of-amygdala-subnuclei-in-nociceptive-and-depressive-like-behaviors-in-peripheral-neuropathy
#12
Midiã D J Seno, Danielle V Assis, Flávia Gouveia, Geiza F Antunes, Mayra Kuroki, Caroline C Oliveira, Lennon C T Santos, Rosana L Pagano, Raquel C R Martinez
The amygdala is an important component of the limbic system that participates in the control of the pain response and modulates the affective-motivational aspect of pain. Neuropathic pain is a serious public health problem and has a strong affective-motivational component that makes it difficult to treat. The central (CeA), basolateral (BLA) and lateral (LA) nuclei of the amygdala are involved in the processing and regulation of chronic pain. However, the roles of these nuclei in the maintenance of neuropathic pain, anxiety and depression remain unclear...
September 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30195871/role-of-curcumin-in-the-management-of-pathological-pain
#13
REVIEW
Jia Sun, Fei Chen, Cody Braun, Ya-Qun Zhou, Heike Rittner, Yu-Ke Tian, Xiu-Yu Cai, Da-Wei Ye
BACKGROUND: Pathological pain conditions can be triggered after peripheral nerve injury and/or inflammation. It is a major clinical problem that is poorly treated with available therapeutics. Curcumin is a phenolic compound derived from Curcuma longa, being widely used for its antioxidant, anti-inflammatory and immunomodulatory effects. PURPOSE: This review systematically summarized updated information on the traditional uses of curcumin in order to explore antinociceptive effects in pathological pain and evaluate future therapeutic opportunities clinically...
September 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30195220/gait-analysis-of-patients-with-continuous-proximal-sciatic-nerve-blockade-in-flexion-contractures-after-primary-total-knee-arthroplasty
#14
Meng Zhou, Shuai An, Mingli Feng, Zheng Li, Huiliang Shen, Kuan Zhang, Jun Sun, Guanglei Cao
BACKGROUND: The main objective of total knee arthroplasty is to relieve pain, restore normal knee function, and improve gait stability. Significant flexion contractures can severely impair function after surgery. The purpose of this study is to evaluate the efficacy of implementing a continuous proximal sciatic nerve block in conjunction with aggressive physical therapy to treat patients with persistent flexion contractures that were recalcitrant to rehabilitation efforts following primary total knee arthroplasty (TKA)...
August 31, 2018: Gait & Posture
https://www.readbyqxmd.com/read/30192300/role-of-receptor-interacting-protein-1-receptor-interacting-protein-3-in-inflammation-and-necrosis-following-chronic-constriction-injury-of-the-sciatic-nerve
#15
Shaofeng Pu, Shuangyue Li, Yongming Xu, Junzhen Wu, Yingying Lv, Dongping Du
Nerve damage often leads to nervous system dysfunction and neuropathic pain. The serine-threonine kinases receptor-interacting protein 1 (RIP1) and 3 (RIP3) are associated with inflammation and cell necrosis. This study aimed to explore the role of RIP1 and RIP3 in sciatic nerve chronic constriction injury (CCI) in mice. On a total of thirty mice, sciatic nerve CCI was performed. The paw withdrawal threshold was measured using Von Frey filaments. The mRNA expression and protein levels of inflammatory factors RIP1 and RIP3 in the dorsal root ganglion (DRG), spinal cord (SC) and hippocampus (HIP) were also determined...
September 5, 2018: Neuroreport
https://www.readbyqxmd.com/read/30192297/epineurial-nerve-coaptation-a-biological-nonliving-training-model-using-gradually-thawed-cryopreserved-sciatic-nerves
#16
Ali-Farid Safi, Sema Safi, Marco Timmer, Roland Goldbrunner, Martin Kauke
The authors present a novel biological nonliving epineurial nerve coaptation training model, which allows cost-efficient practicing on organic mammal nerves and offers an objective performance control on the basis of successful suturing and respecting the 3R model.Anatomic dissection of 40 rat cadavers was performed. Four residents without prior microneurosurgical experience were included. Each trainee performed 20 epineurial nerve coaptations. The number of successful sutures served as qualitative variable and operation time as a quantitative variable for efficiency control...
September 5, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30187947/mir-134-5p-attenuates-neuropathic-pain-progression-through-targeting-twist1
#17
Li-Juan Ji, Jing Su, An-Le Xu, Bo Pang, Qiang-Min Huang
Neuropathic pain is a kind of chronic pain because of dysfunctions of somatosensory nerve system. Recently, many studies have demonstrated that microRNAs (miRs) play crucial roles in neuropathic pain development. This study was designed to investigate the effects of miR-134-5p on the process of neuropathic pain progression in a rat model established by chronic sciatic nerve injury (CCI). First, we observed that miR-134-5p was significantly decreased in CCI rat models. Overexpression of miR-134-5p strongly alleviated neuropathic pain behaviors including mechanical and thermal hyperalgesia...
September 6, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30187183/fracture-related-ulnar-and-sciatic-nerve-transections-a-report-of-two-cases-and-literature-review
#18
Russell A Payne, Emily P Sieg, Nathan Patrick, Michael Darowish, Elias Rizk, Sara Langan, Kimberly Harbaugh
INTRODUCTION: Case reports, case series, and case control studies have looked at the incidence of complete nerve transection in the setting of fracture and the need for surgical exploration dating back to the 1920s. We present two cases of nerve laceration accompanying traumatic fracture with a thorough review of the literature. METHODS: We used the following search terms: "ulnar nerve" OR "sciatic nerve" AND "laceration" OR "transection" AND "fracture...
September 5, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30186905/total-hip-arthroplasty-and-femoral-nail-lengthening-for-hip-dysplasia-and-limb-length-discrepancy
#19
Elizabeth Harkin, S Robert Rozbruch, Tomas Liskutin, William Hopkinson, Mitchell Bernstein
The application of distraction osteogenesis through the use of magnet-operated, remote-controlled intramedullary lengthening continues to provide new opportunities for accurate limb equalization. While limb-length discrepancy and deformity can be addressed by total hip arthroplasty alone, the magnitude of correction is limited by the soft-tissue envelope and complications such as sciatic nerve palsy. This 3-patient case series presents the combination of staged ipsilateral total hip arthroplasty and retrograde intramedullary femoral nail lengthening for the correction of both deformity and limb-length discrepancy...
September 2018: Arthroplasty Today
https://www.readbyqxmd.com/read/30186571/itraq-based-proteomics-profiling-of-schwann-cells-before-and-after-peripheral-nerve-injury
#20
Gui-Dong Shi, Xin Cheng, Xian-Hu Zhou, Bao-You Fan, Yi-Ming Ren, Wei Lin, Xiao-Lei Zhang, Shen Liu, Yan Hao, Zhi-Jian Wei, Shi-Qing Feng
Objectives: Schwann cells (SCs) have a wide range of applications as seed cells in the treatment of nerve injury during transplantation. However, there has been no report yet on kinds of proteomics changes that occur in Schwann cells before and after peripheral nerve injury. Materials and Methods: Activated Schwann cells (ASCs) and normal Schwann cells (NSCs) were obtained from adult Wistar rat sciatic nerves. After immunofluorescence identification, we identified differentially expressed proteins in the ASCs and NSCs using isobaric tags for relative and absolute quantitation (iTRAQ) combined with high-resolution Orbitrap liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS)...
August 2018: Iranian Journal of Basic Medical Sciences
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