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https://www.readbyqxmd.com/read/29331274/clinical-outcomes-of-endoscopic-submucosal-dissection-for-large-colorectal-laterally-spreading-tumors-in-older-adults
#1
Jing Jing Lian, Li Li Ma, Yi Qun Zhang, Wei Feng Chen, Yun Shi Zhong, Mei Dong Xu, Ping Hong Zhou, Shi Yao Chen
BACKGROUND AND AIMS: The colorectal endoscopic submucosal dissection (ESD) remains technically challenging, especially for older patients who frequently encounter complex chronic diseases and have a loose colon. However, only limited number of studies are available for the safety of ESD in older patients with especially large laterally spreading tumors. Therefore, in this retrospective study, we compared the outcomes of ESD for laterally spreading tumors (LST) ≥3cm(cm) in older patients to that in younger patients...
January 10, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29330837/computer-simulated-modeling-of-healthy-and-diseased-right-ventricular-and-pulmonary-circulation
#2
Jody Chou, Joseph B Rinehart
We have previously developed a simulated cardiovascular physiology model for in-silico testing and validation of novel closed-loop controllers. To date, a detailed model of the right heart and pulmonary circulation was not needed, as previous controllers were not intended for use in patients with cardiac or pulmonary pathology. With new development of controllers for vasopressors, and looking forward, for combined vasopressor-fluid controllers, modeling of right-sided and pulmonary pathology is now relevant to further in-silico validation, so we aimed to expand our existing simulation platform to include these elements...
January 12, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29330304/efficient-prion-disease-transmission-through-common-environmental-materials
#3
Sandra Pritzkow, Rodrigo Morales, Adam Lyon, Luis Concha-Marambio, Akihiko Urayama, Claudio Soto
Prion diseases are a group of fatal neurodegenerative diseases associated with a protein-based infectious agent, termed prion. Compelling evidence suggests that natural transmission of prion diseases is mediated by environmental contamination with infectious prions. We hypothesized that several natural and man-made materials, commonly found in the environments of wild and captive animals, can bind prions and may act as vectors for disease transmission. To test our hypothesis, we exposed surfaces composed of various common environmental materials (i...
January 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29330075/the-epidemic-model-based-on-the-approximation-for-third-order-motifs-on-networks
#4
Jinxian Li, Weiqiang Li, Zhen Jin
The spread of an infectious disease may depend on the structure of the network. To study the influence of the structure parameters of the network on the spread of the epidemic, we need to put these parameters into the epidemic model. The method of moment closure introduces structure parameters into the epidemic model. In this paper, we present a new moment closure epidemic model based on the approximation of third-order motifs in networks. The order of a motif defined in this paper is determined by the number of the edges in the motif, rather than by the number of nodes in the motif as defined in the literature...
January 9, 2018: Mathematical Biosciences
https://www.readbyqxmd.com/read/29329534/a-large-scale-study-of-a-poultry-trading-network-in-bangladesh-implications-for-control-and-surveillance-of-avian-influenza-viruses
#5
N Moyen, G Ahmed, S Gupta, T Tenzin, R Khan, T Khan, N Debnath, M Yamage, D U Pfeiffer, G Fournie
BACKGROUND: Since its first report in 2007, avian influenza (AI) has been endemic in Bangladesh. While live poultry marketing is widespread throughout the country and known to influence AI dissemination and persistence, trading patterns have not been described. The aim of this study is to assess poultry trading practices and features of the poultry trading networks which could promote AI spread, and their potential implications for disease control and surveillance. Data on poultry trading practices was collected from 849 poultry traders during a cross-sectional survey in 138 live bird markets (LBMs) across 17 different districts of Bangladesh...
January 12, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29329410/1918-h1n1-influenza-virus-replicates-and-induces-pro-inflammatory-cytokine-responses-in-extra-respiratory-tissues-of-ferrets
#6
Emmie de Wit, Jurre Siegers, Jacqueline M Cronin, Sarah Weatherman, Judith van den Brand, Lonneke M Leijten, Peter van Run, Lineke Begeman, Henk-Jan van den Ham, Arno C Andeweg, Trenton Bushmaker, Dana P Scott, Greg Saturday, Vincent J Munster, Heinz Feldmann, Debby van Riel
Background: The 1918 Spanish H1N1 influenza pandemic was the most severe recorded influenza pandemic with an estimated 20-50 million deaths worldwide. Even though it is known that influenza viruses can cause extra-respiratory tract complications-which are often severe or even fatal- the potential contribution of extra-respiratory tissues to the pathogenesis of 1918 H1N1 virus infection has not been studied comprehensively. Methods: Here, we performed a time course study in ferrets inoculated intranasally with 1918 H1N1 virus, with special emphasis on the involvement of extra-respiratory tissues...
January 10, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29329394/analysis-of-the%C3%A2-aedes-albopictus%C3%A2-c6-36-genome-provides-insight-into-cell-line-utility-for-viral-propagation
#7
Jason R Miller, Sergey Koren, Kari A Dilley, Vinita Puri, David M Brown, Derek M Harkins, Françoise Thibaud-Nissen, Benjamin Rosen, Xiao-Guang Chen, Zhijian Tu, Igor V Sharakhov, Maria V Sharakhova, Robert Sebra, Timothy B Stockwell, Nicholas H Bergman, Granger G Sutton, Adam M Phillippy, Peter M Piermarini, Reed S Shabman
Background: The 50-year old Aedes albopictus C6/36 cell line is a resource for the detection, amplification, and analysis of mosquito-borne viruses including Zika, dengue, and chikungunya. The cell line is derived from an unknown number of larvae from an unspecified strain of Aedes albopictus mosquitoes. Toward improved utility of the cell line for research in virus transmission, we present an annotated assembly of the C6/36 genome. Results: The C6/36 genome assembly has the largest contig N50 (3...
January 10, 2018: GigaScience
https://www.readbyqxmd.com/read/29328646/vibrational-properties-of-bulk-boric-acid-2a-and-3t-polymorphs-and-their-two-dimensional-layers-measurements-and-density-functional-theory-calculations
#8
Mauricelio Bezerra da Silva, Regina C R Santos, Paulo T C Freire, Ewerton W S Caetano, Valder N Freire
Boric acid (H3BO3) is being used effectively nowadays in traps/baits for the management of Aedes aegypti L. and Aedes albopictus Skuse species of mosquitoes, which are the main spreading vectors worldwide for diseases like malaria, dengue and zika. Previously, we have published results on the structural, electronic and optical properties of its molecular triclinic H3BO3-2A and trigonal H3BO3-3T polymorphs within the framework of density functional theory (DFT). Due to the renewed importance of these materials, the focus of this work is on the vibrational properties of the bulk boric acid 2A and 3T polymorphs...
January 12, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29327375/impact-of-hiv-aids-epidemic-on-human-capital-development-in-west-africa
#9
Rasaki Stephen Dauda
West Africa occupies the third position with respect to the burden of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) globally, after Southern and East Africa. About 5 million adults and children are infected with the disease in the subregion, while HIV prevalence in the general population hovers around 2% and 5%. This paper attempts to investigate the impact of HIV/AIDS epidemic on human capital development in 11 West African countries over the period 1990 to 2011. The study used a dynamic panel data modeling approach, using first difference, difference generalized methods of moment, and system generalized methods of moment estimating techniques...
January 12, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29326010/genomics-of-corynebacterium-striatum-an-emerging-multi-drug-resistant-pathogen-of-immunocompromised-patients
#10
Kathleen Nudel, Xiaomin Zhao, Sankha Basu, Xiaoxi Dong, Maria Hoffmann, Michael Feldgarden, Marc Allard, Michael Klompas, Lynn Bry
OBJECTIVES: Corynebacterium striatum is an emerging multi-drug resistant (MDR) pathogen of immunocompromised and chronically ill patients. The objective of these studies was to provide a detailed genomic analysis of disease causing C. striatum and determine the genomic drivers of resistance and resistance-gene transmission. METHODS: A multi-institutional and prospective pathogen genomics program flagged seven MDR C. striatum infections occurring close in time, and specifically in immunocompromised patients with underlying respiratory diseases...
January 8, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29325425/meningitis-vaccination-knowledge-and-awareness-among-ymsm-in-chicago
#11
Gregory Phillips, Amy K Johnson, Christian N Adames, Brian Mustanski
Serogroup C invasive meningococcal disease (IMD) outbreaks in men who have sex with men (MSM) have been occurring with greater frequency in urban areas across the United States. An effective vaccine for IMD is available and is recommended for MSM in outbreak settings. Particular subgroups of MSM have been disproportionately represented in outbreaks, specifically young, Black, and HIV-positive MSM. As little is known about the knowledge, awareness, and vaccination status of young MSM, we sought to describe this and explore racial/ethnic differences...
January 1, 2018: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29324702/listeria-monocytogenes-the-impact-of-cell-death-on-infection-and-immunity
#12
REVIEW
Courtney E McDougal, John-Demian Sauer
Listeria monocytogenes has evolved exquisite mechanisms for invading host cells and spreading from cell-to-cell to ensure maintenance of its intracellular lifecycle. As such, it is not surprising that loss of the intracellular replication niche through induction of host cell death has significant implications on the development of disease and the subsequent immune response. Although L. monocytogenes can activate multiple pathways of host cell death, including necrosis, apoptosis, and pyroptosis, like most intracellular pathogens L...
January 11, 2018: Pathogens
https://www.readbyqxmd.com/read/29324360/evaluation-of-the-zoonotic-potential-of-multiple-subgroups-of-clade-2-3-4-4-influenza-a-h5n8-virus
#13
Yu-Na Lee, Eun-Kyoung Lee, Byung-Min Song, Gyeong-Beom Heo, Sang-Hee Woo, Sun-Ha Cheon, Youn-Jeong Lee
Clade 2.3.4.4 H5N8 highly pathogenic avian influenza viruses (HPAIVs) have spread worldwide. Phylogenetic analysis identified two genetic groups of the H5N8 HPAIVs in South Korea; group A evolved further into four subgroups. Here, we examined the zoonotic potential, both in vivo and in vitro, of genetically distinct subgroups of H5N8 HPAIVs isolated in South Korea. When compared with other subgroups, A/mallard/Korea/H2102/2015 (H2102) virus caused relatively severe disease in mice at high doses. In ferrets, all H5N8 viruses replicated restrictively in the respiratory tract and did not induce significant clinical signs of influenza infection...
January 8, 2018: Virology
https://www.readbyqxmd.com/read/29324212/managing-patients-with-oligometastatic-non-small-cell-lung-cancer
#14
Sarah Jo Stephens, Michael J Moravan, Joseph K Salama
Metastatic lung cancer has long been considered incurable, with the goal of treatment being palliation. However, a clinically meaningful number of these patients with limited metastases (approximately 25%) are living long term after definitive treatment to all sites of active disease. These patients with so-called oligometastatic disease likely represent a distinct clinical group who may possess a more indolent biology compared with their more widely metastatic counterparts. Hellman and Weichselbaum proposed the existence of the oligometastatic state, on the basis of the spectrum theory of cancer spread...
January 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29322852/anion-inhibition-studies-of-a-beta-carbonic-anhydrase-from-the-malaria-mosquito-anopheles-gambiae
#15
Daniela Vullo, Leo Syrjänen, Marianne Kuuslahti, Seppo Parkkila, Claudiu T Supuran
An anion inhibition study of the β-class carbonic anhydrase, AgaCA, from the malaria mosquito Anopheles gambiae is reported. A series of simple as well as complex inorganic anions, and small molecules known to interact with CAs were included in the study. Bromide, iodide, bisulphite, perchlorate, perrhenate, perruthenate, and peroxydisulphate were ineffective AgaCA inhibitors, with KIs > 200 mM. Fluoride, chloride, cyanate, thiocyanate, cyanide, bicarbonate, carbonate, nitrite, nitrate, sulphate, stannate, selenate, tellurate, diphosphate, divanadate, tetraborate, selenocyanide, and trithiocarbonate showed KIs in the range of 1...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29322642/peste-des-petits-ruminants-in-china-since-its-first-outbreak-in-2007-a-10-year-review
#16
REVIEW
F Liu, J Li, L Li, Y Liu, X Wu, Z Wang
Peste des petits ruminants (PPR) is a highly infectious disease of small ruminants and caused by small ruminant morbillivirus (SRMV), formerly called peste-des-petits-ruminants virus (PPRV). This disease is circulating in Africa (except most countries in southern Africa), the Arabian Peninsula, the Middle East, and Central, East and South-East Asia. Peste des petits ruminants is still regarded as an exotic disease in China, where its first outbreak was reported in the Ngari region of Tibet in 2007, but effectively controlled by slaughter, vaccination and animal movement restriction in PPR-infected areas...
January 10, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29322411/in-vivo-infection-model-of-severe-influenza-a-virus
#17
Ashley Mansell, Michelle D Tate
The lung is constantly exposed to both environmental and microbial challenge. As a "contained" organ, it also constitutes an excellent "self-contained" tissue to examine inflammatory responses and cellular infiltration into a diseased organ. Influenza A virus (IAV) causes both mild and severe inflammation that is strain specific following infection of the lung epithelium that spreads to other cells of the lung environment. Here, we describe a method of intranasal inoculation of the lung with IAV that can be used as a preclinical model of infection...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29322051/genetic-variation-of-the-%C3%AE-tubulin-gene-of-babesia-caballi-strains
#18
María Guadalupe Montes-Cortés, José Luis Fernández-García, Miguel Ángel Habela Martínez-Estéllez
Background: Equine piroplasmosis is caused by two haemoprotozoan parasites: Babesia caballi and Theileria equi. Negative economic impact on international trade has been associated to endemic sites. This is the reason why carrier detection requires reliable diagnostic methods. Various diagnostic modalities can be used alone or in combination including PCR. However, genetic variation of commonly used genes is still of debate. The aim of this research was to sequence the β-tubulin gene of a B...
September 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29321868/global-mtdna-genetic-structure-and-hypothesized-invasion-history-of-a-major-pest-of-citrus-diaphorina-citri-hemiptera-liviidae
#19
Yufa Luo, Ingi Agnarsson
The Asian citrus psyllid Diaphorina citri Kuwayama is a key pest of citrus as the vector of the bacterium causing the "huanglongbing" disease (HLB). To assess the global mtDNA population genetic structure, and possible dispersal history of the pest, we investigated genetic variation at the COI gene collating newly collected samples with all previously published data. Our dataset consists of 356 colonies from 106 geographic sites worldwide. High haplotype diversity (H-mean = 0.702 ± 0.017), low nucleotide diversity (π-mean = 0...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321551/aster-leafhopper-survival-and-reproduction-and-aster-yellows-transmission-under-static-and-fluctuating-temperatures-using-ddpcr-for-phytoplasma-quantification
#20
Md H Bahar, Tyler J Wist, Diana R Bekkaoui, Dwayne D Hegedus, Chrystel Y Olivier
Aster yellows (AY) is an important disease of Brassica crops and is caused by Candidatus Phytoplasma asteris and transmitted by the insect vector, Aster leafhopper (Macrosteles quadrilineatus). Phytoplasma-infected Aster leafhoppers were incubated at various constant and fluctuating temperatures ranging from 0 to 35 °C with the reproductive host plant barley (Hordium vulgare). At 0 °C, leafhopper adults survived for 18 days, but failed to reproduce, whereas at 35 °C insects died within 18 days, but successfully reproduced before dying...
January 10, 2018: Scientific Reports
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