Kiran K Khush, James L Bernat, Richard N Pierson, Henry J Silverman, Brendan Parent, Alexandra K Glazier, Andrew B Adams, Jay A Fishman, Michael Gusmano, Wayne J Hawthorne, Mary E Homan, Daniel J Hurst, Stephen Latham, Chung-Gyu Park, Karen J Maschke, Muhammad M Mohiuddin, Robert A Montgomery, Jonah Odim, Rebecca D Pentz, Bruno Reichart, Julian Savulescu, Paul Root Wolpe, Renee P Wong, Kathleen N Fenton
Xenotransplantation offers the potential to meet the critical need for heart and lung transplantation presently constrained by the current human donor organ supply. Much was learned over the past decades regarding gene editing to prevent the immune activation and inflammation that cause early organ injury, and strategies for maintenance of immunosuppression to promote longer-term xenograft survival. However, many scientific questions remain regarding further requirements for genetic modification of donor organs, appropriate contexts for xenotransplantation research (including nonhuman primates, recently deceased humans, and living human recipients), and risk of xenozoonotic disease transmission...
March 19, 2024: American Journal of Transplantation