Zekang Su, Yali Zhang, Shiyi Hong, Qiaojian Zhang, Jiayu Xu, Guiping Hu, Xiaojun Zhu, Fang Yuan, Shanfa Yu, Tianchen Wang, Guang Jia
Hexavalent chromium and its compounds are prevalent pollutants, especially in the work environment, pose a significant risk for multisystem toxicity and cancers. While it is known that chromium accumulation in the liver can cause damage, the dose-response relationship between blood chromium (Cr) and liver injury, as well as the possible potential toxic mechanisms involved, remains poorly understood. To address this, we conducted a follow-up study of 590 visits from 305 participants to investigate the associations of blood Cr with biomarkers for liver injury, including serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), and direct bilirubin (DBIL), and to evaluate the mediating effects of systemic inflammation...
September 2024: Journal of Environmental Sciences (China)