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https://www.readbyqxmd.com/read/28088102/effects-of-photoperiod-regimes-and-ultraviolet-c-radiations-on-biosynthesis-of-industrially-important-lignans-and-neolignans-in-cell-cultures-of-linum-usitatissimum-l-flax
#1
Sumaira Anjum, Bilal Haider Abbasi, Joël Doussot, Alain Favre-Réguillon, Christophe Hano
Lignans and neolignans are principal bioactive components of Linum usitatissimum L. (Flax), having multiple pharmacological activities. In present study, we are reporting an authoritative abiotic elicitation strategy of photoperiod regimes along with UV-C radiations. Cell cultures were grown in different photoperiod regimes (24h-dark, 24h-light and 16L/8D h photoperiod) either alone or in combination with various doses (1.8-10.8kJ/m(2)) of ultraviolet-C (UV-C) radiations. Secoisolariciresinol diglucoside (SDG), lariciresinol diglucoside (LDG), dehydrodiconiferyl alcohol glucoside (DCG), and guaiacylglycerol-β-coniferyl alcohol ether glucoside (GGCG) were quantified by using reverse phase-high performance liquid chromatography (RP-HPLC)...
January 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28081282/cloning-of-three-genes-involved-in-the-flavonoid-metabolic-pathway-and-their-expression-during-insect-resistance-in-pinus-massoniana-lamb
#2
Z Q Yang, H Chen, J H Tan, H L Xu, J Jia, Y H Feng
Pinus massoniana Lamb. is an important timber and turpentine-producing tree species in China. Dendrolimus punctatus and Dasychira axutha are leaf-eating pests that have harmful effects on P. massoniana production. Few studies have focused on the molecular mechanisms underlying pest resistance in P. massoniana. Based on sequencing analysis of the transcriptomes of insect-resistant P. massoniana, three key genes involved in the flavonoid metabolic pathway were identified in the present study (PmF3H, PmF3'5'H, and PmC4H)...
December 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28081272/individual-plasticity-of-the-shade-response-of-the-invasive-solidago-canadensis-in-china
#3
Leshan Du, Haiyan Liu, Ming Yan, Junmin Li, Junsheng Li
To evaluate the population variation, individual plasticity, and local adaptability of Solidago canadensis in response to shade treatment, we conducted a common pots experiment with a total of 150 ramets (5 genets, 15 populations, and 2 treatments) subjected to both control (natural light) and shady treatment (10% of natural light). Shade treatment significantly reduced growth and content of defense metabolites in S. canadensis. Compared to control, shading led to increased height, decreased basal diameter, increased leaf width, increased leaf length, increased chlorophyll content, stronger photosynthetic rate (Pn), stronger stomatal conductance (gs), and lower root to shoot ratio...
2017: PloS One
https://www.readbyqxmd.com/read/28079924/optimized-microwave-assistant-extraction-combined-ultrasonic-pretreatment-of-flavonoids-from-periploca-forrestii-schltr-and-evaluation-of-its-anti-allergic-activity
#4
Qian Liang, Huaguo Chen, Xin Zhou, Qingfang Deng, Enming Hu, Chao Zhao, Xiaojian Gong
Microwave extraction combined ultrasonic pretreatment of flavonoids from Periploca forrestii Schltr. was investigated in this study, extraction process was firstly performed in an ultrasonic cleaner, then treated by microwave irradiation. The optimum ultrasonic time of 25 min was selected by single-factor experiments. A response surface methodology (RSM) has been used to obtain a mathematical model that describes the process and analyzes the significant parameters ethanol concentration 59.92%, liquid to raw materials ratio 21...
January 12, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28079108/improving-the-concentrations-of-the-active-components-in-the-herbal-tea-ingredient-uraria-crinita-the-effect-of-post-harvest-oven-drying-processing
#5
Jung Chao, Yuntao Dai, Hao-Yuan Cheng, Wing Lam, Yung-Chi Cheng, Ke Li, Wen-Huang Peng, Li-Heng Pao, Ming-Tsuen Hsieh, Xue-Mei Qin, Meng-Shiou Lee
Uraria crinita is widely used as a popular folk drink; however, little is known about how the post-harvest operations affect the chemical composition and bioactivity of UC. We assessed three drying methods (Oven-drying, Air-drying, Sun-drying), as well as the Oven-drying temperature using metabolomics approaches and bioactivity assays. The samples processed at 40 degree show a greater effect on the levels of estrogen receptor-alpha activity and nuclear factor erythroid 2-related factor 2 activity, anti-oxidative activity, and cyclooxygenase-2 inhibition compared with the other samples...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28079013/natural-product-inhibitors-of-topoisomerases-review-and-docking-study
#6
L Scotti, F J B Mendonça Júnior, F F Ribeiro, J F Tavares, M S Da Silva, J M Barbosa Filho, M T Scotti
Since ancient times, natural products have been used in treating various diseases effectively and safely. Nowadays, these natural compounds are submitted to sophisticated methodologies from isolation, computing, analytical, and even serving as pharmacophore suggestions for synthesis. The substances extracted from marine species, plants, and microorganisms present activities beneficial to our health, including protection against malignant tumors. The topoisomerase enzymes play an important role in DNA metabolism, and searching for enzyme inhibitors is an important target in the search for new anticancer drugs...
January 11, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28078783/new-propolis-type-from-northeast-brazil-chemical-composition-antioxidant-activity-and-botanical-origin
#7
Joselena M Ferreira, Caroline C Fernandes-Silva, Antonio Salatino, Giuseppina Negri, Dejair Message
BACKGROUND: Propolis is a bee product with wide diversity of biological activity. It has complex composition, which is dependent on its botanical source. The present work aimed at determining the chemical profile, antioxidant activity and botanical origin of two samples of a propolis type from two locations of the state of Rio Grande do Norte (RN, northeast Brazil). RESULTS: The standard chemical characteristics of the RN propolis are similar or superior to the internationally marketed Brazilian green propolis...
January 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28078420/comprehensive-polyphenol-profiling-of-a-strawberry-extract-fragaria-%C3%A3-ananassa-by-ultra-high-performance-liquid-chromatography-coupled-with-high-resolution-mass-spectrometry
#8
Giorgia La Barbera, Anna Laura Capriotti, Chiara Cavaliere, Susy Piovesana, Roberto Samperi, Riccardo Zenezini Chiozzi, Aldo Laganà
The aim of metabolic untargeted profiling is to detect and identify unknown compounds in a biological matrix to achieve the most comprehensive metabolic coverage. In phytochemical mixtures, however, the complexity of the sample could present significant difficulties in compound identification. In this case, the optimization of both the chromatographic and the mass-spectrometric conditions is supposed to be crucial for the detection and identification of the largest number of compounds. In this work, a systematic investigation of different chromatographic and mass-spectrometric conditions is presented to achieve a comprehensive untargeted profiling of a strawberry extract (Fragaria × ananassa)...
January 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28078258/multiresponse-optimization-and-prediction-of-antioxidant-properties-of-aqueous-ginger-extract
#9
Solomon Akinremi Makanjuola, Victor Ndigwe Enujiugha, Olufunmilayo Sade Omoba
The influence of extraction temperature, powder concentration, and extraction time on the antioxidant properties of aqueous ginger extract was investigated. The possibility of estimating the antioxidant properties of the extract from its absorbance and colour properties was also investigated. Results indicated that powder concentration was the most significant factor to consider in optimizing antioxidant extraction. However, temperature and time still influenced the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity while extraction temperature influenced the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of the extract...
December 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28078255/quality-characteristics-and-antioxidant-activity-of-yogurt-supplemented-with-aronia-aronia-melanocarpa-juice
#10
Linh Nguyen, Eun-Sun Hwang
We investigated the quality characteristics and antioxidant activities of yogurt supplemented with 1%, 2%, and 3% aronia juice and fermented for 24 h at 37°C. The total acidity increased with increasing levels of aronia juice and incubation time. Lightness and yellowness of the yogurt decreased, but redness increased, with increasing aronia juice content and incubation time. The number of lactic acid bacteria (LAB) increased with increased incubation time, and yogurt containing 2% and 3% aronia juice showed higher LAB counts than 1% aroinia juice-supplemented yogurt...
December 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28077078/transcriptomic-evidence-for-the-control-of-soybean-root-isoflavonoid-content-by-regulation-of-overlapping-phenylpropanoid-pathways
#11
Mehran Dastmalchi, Patrick Chapman, Jaeju Yu, Ryan S Austin, Sangeeta Dhaubhadel
BACKGROUND: Isoflavonoids are a class of specialized metabolites found predominantly in legumes. They play a role in signaling for symbiosis with nitrogen-fixing bacteria and inhibiting pathogen infection. RESULTS: A transcriptomic approach using soybean cultivars with high (Conrad and AC Colombe) and low (AC Glengarry and Pagoda) root isoflavonoid content was used to find elements that underlie this variation. Two genes, encoding the flavonoid-metabolizing enzymes, flavonoid 3'-hydroxylase (GmF3'H) and dihydroflavonol 4-reductase (GmDFR), had lower expression levels in high isoflavonoid cultivars...
January 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28076987/antioxidant-activity-and-cholinesterase-inhibition-studies-of-four-flavouring-herbs-from-alentejo
#12
Sílvia Arantes, Andreia Piçarra, Fátima Candeias, A Teresa Caldeira, M Rosário Martins
Essential oils (EOs) and aqueous extracts of aerial parts of four aromatic species, Calamintha nepeta, Foeniculum vulgare, Mentha spicata and Thymus mastichina, from southwest of Portugal were characterised chemically and analysed in order to evaluate their antioxidant potential and cholinesterase inhibitory activities. The main components of EOs were oxygenated monoterpenes, and aqueous extracts were rich in phenol and flavonoid compounds. EOs and aqueous extracts presented a high antioxidant potential, with ability to protect the lipid substrate, free radical scavenging and iron reducing power...
January 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28074659/ferulic-acid-fa-abrogates-%C3%AE-radiation-induced-oxidative-stress-and-dna-damage-by-up-regulating-nuclear-translocation-of-nrf2-and-activation-of-nhej-pathway
#13
Ujjal Das, Krishnendu Manna, Amitava Khan, Mahuya Sinha, Sushobhan Biswas, Aaveri Sengupta, Anindita Chakraborty, Sanjit Dey
The present study was aimed to evaluate the radioprotective effect of ferulic acid (FA), a naturally occurring plant flavonoid in terms of DNA damage and damage related alterations of repair pathways by gamma radiation. FA was administered at a dose of 50 mg/kg body weight for five consecutive days prior to exposing the swiss albino mice to a single dose of 10 Gy gamma radiation. Ionising radiation induces oxidative damage manifested by decreased expression of Cu, Zn-SOD (SOD stands for super oxide dismutase), Mn-SOD and catalase...
January 11, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28074384/microfluidic-gut-liver-chip-for-reproducing-the-first-pass-metabolism
#14
Aerim Choe, Sang Keun Ha, Inwook Choi, Nakwon Choi, Jong Hwan Sung
After oral intake of drugs, drugs go through the first pass metabolism in the gut and the liver, which greatly affects the final outcome of the drugs' efficacy and side effects. The first pass metabolism is a complex process involving the gut and the liver tissue, with transport and reaction occurring simultaneously at various locations, which makes it difficult to be reproduced in vitro with conventional cell culture systems. In an effort to tackle this challenge, here we have developed a microfluidic gut-liver chip that can reproduce the dynamics of the first pass metabolism...
March 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28073929/improving-heterologous-production-of-phenylpropanoids-in-saccharomyces-cerevisiae-by-tackling-an-unwanted-side-reaction-of-tsc13-an-endogenous-double-bond-reductase
#15
Beata Joanna Lehka, Michael Eichenberger, Walden Emil Bjørn-Yoshimoto, Katherina Garcia Vanegas, Nicolaas Buijs, Niels Bjerg Jensen, Jane Dannow Dyekjær, Håvard Jenssen, Ernesto Simon, Michael Naesby
Phenylpropanoids, such as flavonoids and stilbenoids, are of great commercial interest, and their production in S. cerevisiae is a very promising strategy. However, to achieve commercially viable production, each step of the process must be optimized. We looked at carbon loss, known to occur in the heterologous flavonoid pathway in yeast, and identified an endogenous enzyme, the enoyl reductase Tsc13, which turned out to be responsible for the accumulation of phloretic acid via reduction of p-coumaroyl-CoA...
January 10, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28073081/antibacterial-effect-of-405%C3%A2-5nm-light-emitting-diode-illumination-against-escherichia-coli-o157-h7-listeria-monocytogenes-and-salmonella-on-the-surface-of-fresh-cut-mango-and-its-influence-on-fruit-quality
#16
Min-Jeong Kim, Chee Hwa Tang, Woo Suk Bang, Hyun-Gyun Yuk
To investigate a potential of 405±5nm light emitting diode (LED) as a novel technology for food preservation, the antibacterial effect of 405±5nm LED on Escherichia coli O157:H7, Listeria monocytogenes, and Salmonella spp. on the surface of fresh-cut mango and its influence on fruit quality were evaluated at different storage temperatures. LED-illumination inactivated 1.0-1.6 logCFU/cm(2) of populations at 4 and 10°C for 36-48h (total dose, 2.6-3.5kJ/cm(2)) regardless of bacterial species, while those on non-illuminated mange remained unchanged or slightly increased during storage...
December 30, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28072821/maysin-and-its-flavonoid-derivative-from-centipedegrass-attenuates-amyloid-plaques-by-inducting-humoral-immune-response-with-th2-skewed-cytokine-response-in-the-tg-appswe-ps1de9-alzheimer-s-mouse-model
#17
Yuno Song, Hong-Duck Kim, Min-Kwon Lee, Il-Hwa Hong, Chung-Kil Won, Hyoung-Woo Bai, Seung Sik Lee, SungBeom Lee, Byung Yeoup Chung, Jae-Hyeon Cho
Alzheimer's disease (AD) is a slow, progressive neurodegenerative disease and the most common type of dementia in the elderly. The etiology of AD and its underlying mechanism are still not clear. In a previous study, we found that an ethyl acetate extract of Centipedegrass (CG) (i.e., EA-CG) contained 4 types of Maysin derivatives, including Luteolin, Isoorientin, Rhamnosylisoorientin, and Derhamnosylmaysin, and showed protective effects against Amyloid beta (Aβ) by inhibiting oligomeric Aβ in cellular and in vitro models...
2017: PloS One
https://www.readbyqxmd.com/read/28071026/antiradical-capacity-and-polyphenol-composition-of-asparagus-spears-varieties-cultivated-under-different-sunlight-conditions
#18
Bartosz Kulczyński, Joanna Kobus-Cisowska, Dominik Kmiecik, Anna Gramza-Michałowska, Dorota Golczak, Józef Korczak
BACKGROUND: Asparagus officinalis has a high nutritional value. Asparagus is rich in a number of bioactive compounds, mainly flavonoids (quercetin), glutathione, vitamin C, vitamin E, fructans (inulin and fructooligosaccharides) and phytosterols (b-sitosterol). These compounds may play an important role in human health. The purpose of this study was to examine the antioxidant potential and polyphenol composition of white, pale-colored and green asparagus spears of different cultivars...
July 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28071020/the-effect-of-microwave-roasting-on-the-antioxidant-properties-of-the-bangladeshi-groundnut-cultivar
#19
Abbas Ali, Anowarul Islam, Tarun K Pal
BACKGROUND: Groundnut seeds are an important source of bioactive phenolic compounds with noteworthy antioxidant capacity, which may be enhanced by the microwave roasting process. The aim of this work is   to study the changes in antioxidant activity in groundnut seeds during microwave roasting, as a function of roasting time and extract concentration, in order to maximise the phenolic content and antioxidant activity of roasted seeds. METHODS: The study was conducted to evaluate total phenolic content (TPC), total flavonoid content (TFC), and antioxidative activity of methanolic (GME), ethanolic (GEE), and chloroform (GCE) extracts and methanolic extract of oil (GMO) from groundnut seeds exposed to microwaves...
October 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28071018/effect-of-roasting-degree-on-the-antioxidant-activity-of-different-arabica-coffee-quality-classes
#20
Božana Odžaković, Natalija Džinić, Zoran Kukrić, Slavica Grujić
BACKGROUND: Coffee is one of the most widely consumed beverages in the world, because of its unique sensory properties and physiological properties. Coffee beverages represent a significant source of antioxidants in the consumers' diet and contribute significantly to their daily intake. The aim of this research was to investigate the effect of different roasting degrees on the content of biologically active compounds and antioxidant activity in different quality classes of Arabica coffee...
October 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
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