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Artificial ventilation

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https://www.readbyqxmd.com/read/29334511/evaluation-of-recombinant-factor-viia-tranexamic-acid-and-desmopressin-to-reduce-prasugrel-related-bleeding-a-randomised-placebo-controlled-study-in-a-rabbit-model
#1
Fanny Bonhomme, Thomas Lecompte, Charles M Samama, Anne Godier, Pierre Fontana
BACKGROUND: Prasugrel is a thienopyridine that inhibits platelet aggregation more rapidly and effectively than clopidogrel, with an increased bleeding risk. OBJECTIVE: The current study aimed to evaluate the efficacy of three nonspecific haemostatic drugs - recombinant activated factor VII (rFVIIa), tranexamic acid and desmopressin (DDAVP) - to limit blood loss after administration of prasugrel in a rabbit model of bleeding while also evaluating any prothrombotic effects...
January 13, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29305892/the-involvement-of-the-pathway-connecting-the-substantia-nigra-the-periaqueductal-gray-matter-and-the-retrotrapezoid-nucleus-in-breathing-control-in-a-rat-model-of-parkinson-s-disease
#2
Juliana C Lima, Luiz M Oliveira, Marina T Botelho, Thiago S Moreira, Ana C Takakura
Parkinson's disease (PD) is characterized by a reduction in the number of dopaminergic neurons of the substantia nigra (SNpc), accompanied by motor and non-motor deficiencies such as respiratory failure. Here, our aim was to investigate possible neuronal communications between the SNpc and chemoreceptor neurons within the retrotrapezoid nucleus (RTN), in order to explain neurodegeneration and the loss of breathing function in the 6-OHDA PD animal model. Male Wistar rats received tracer injections in the SNpc, RTN and periaqueductal gray (PAG) regions to investigate the projections between those regions...
January 4, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29298331/detection-of-artificial-pulmonary-lung-nodules-in-ultralow-dose-ct-using-an-ex-vivo-lung-phantom
#3
Caroline Alexandra Burgard, Thomas Gaass, Madeleine Bonert, David Bondesson, Natalie Thaens, Maximilian Ferdinand Reiser, Julien Dinkel
OBJECTIVES: To assess the image quality of 3 different ultralow-dose CT protocols on pulmonary nodule depiction in a ventilated ex vivo-system. MATERIALS AND METHODS: Four porcine lungs were inflated inside a dedicated chest phantom and prepared with n = 195 artificial nodules (0.5-1 mL). The artificial chest wall was filled with water to simulate the absorption of a human chest. Images were acquired with a 2x192-row detector CT using low-dose (reference protocol with a tube voltage of 120 kV) and 3 different ULD protocols (respective effective doses: 1mSv and 0...
2018: PloS One
https://www.readbyqxmd.com/read/29286529/unanticipated-difficult-airway-management-in-children-the-consensus-statement-of-the-paediatric-anaesthesiology-and-intensive-care-section-and-the-airway-management-section-of-the-polish-society-of-anaesthesiology-and-intensive-therapy-and-the-polish-so
#4
Wojciech Walas, Dawid Aleksandrowicz, Maria Borszewska-Kornacka, Tomasz Gaszyński, Ewa Helwich, Marek Migdał, Andrzej Piotrowski, Grażyna Siejka, Tomasz Szczapa, Alicja Bartkowska-Śniatkowska
Tracheal intubation may be defined as an artificial airway established in order to provide mechanical ventilation of the lungs during surgical procedures under general anaesthesia, treatment in an intensive care unit, as well as in emergency situations. Difficulties encountered during intubation may cause hypoxia, hypoxic brain injury and, in extreme situations, may result in the patient's death. There may be unanticipated and anticipated difficult airway. Children form a specific group of patients as there are significant differences in both anatomy and physiology...
2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29247235/effects-of-snow-properties-on-humans-breathing-into-an-artificial-air-pocket-an-experimental-field-study
#5
Giacomo Strapazzon, Peter Paal, Jürg Schweizer, Markus Falk, Benjamin Reuter, Kai Schenk, Hannes Gatterer, Katharina Grasegger, Tomas Dal Cappello, Sandro Malacrida, Lukas Riess, Hermann Brugger
Breathing under snow, e.g. while buried by a snow avalanche, is possible in the presence of an air pocket, but limited in time as hypoxia and hypercapnia rapidly develop. Snow properties influence levels of hypoxia and hypercapnia, but their effects on ventilation and oxygenation in humans are not fully elucidated yet. We report that in healthy subjects breathing into snow with an artificial air pocket, snow density had a direct influence on ventilation, oxygenation and exhaled CO2. We found that a rapid decline in O2 and increase in CO2 were mainly associated with higher snow densities and led to premature interruption due to critical hypoxia (SpO2 ≤ 75%)...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212793/pacap-6-38-or-kynurenate-microinjections-into-the-rvlm-prevent-development-of-sympathetic-long-term-facilitation-following-acute-intermittent-hypoxia
#6
Zohra M Kakall, Paul M Pilowsky, Melissa Mj Farnham
BACKGROUND AND PURPOSE: Intermittent hypoxia causes a persistent increase in sympathetic activity, which progresses to hypertension in chronic conditions such as obstructive sleep apnea (OSA). Pituitary adenylate cyclase activating polypeptide (PACAP) is an excitatory neurotransmitter that causes long-lasting sympathetic excitation. We aimed to determine if intermittent activation of the rostral ventrolateral medulla (RVLM) causes PACAP-mediated elevation of sympathetic nerve activity (sSNA), termed sympathetic long-term facilitation (sLTF)...
December 6, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29202811/high-prevalence-of-prescription-of-psychotropic-drugs-for-older-patients-in-a-general-hospital
#7
Inken Arnold, Kati Straube, Wolfgang Himmel, Stephanie Heinemann, Vivien Weiss, Laura Heyden, Eva Hummers-Pradier, Roland Nau
BACKGROUND: Many elderly patients receive psychotropic drugs. Treatment with psychotropic agents is associated with serious side effects including an increased risk of falls and fractures. Several psychotropic drugs are considered potentially inappropriate for treatment of the elderly. METHODS: A retrospective chart review was conducted covering all patients aged ≥ 65 years who were admitted to Evangelisches Krankenhaus Göttingen-Weende between 01/01/2013 and 03/31/2013...
December 4, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29197374/prevalence-and-associated-factors-of-strabismus-in-former-preterm-and-full-term-infants-between-4-and-10%C3%A2-years-of-age
#8
Achim Fieß, Ruth Kölb-Keerl, Alexander K Schuster, Markus Knuf, Bernd Kirchhof, Philipp S Muether, Jacqueline Bauer
BACKGROUND: Limited data exist collating most of the associated factors for strabismus in one analysis. The aim of this study was to assess the prevalence of strabismus and to analyse associated factors in former preterm and full-term infants. METHODS: In this cross-sectional study, 239 former preterm infants with gestational age (GA) ≤ 32 weeks and 264 former full-term born infants with GA ≥ 37 weeks underwent detailed ophthalmologic examination in the age of 4-10 years and perinatal data assessment for risk factor analysis...
December 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29191721/changes-in-the-use-of-intensive-and-supportive-procedures-for-patients-with-stroke-in-taiwan-in-the-last-month-of-life-between-2000-and-2010
#9
Pei-Yi Wang, Yen-Ni Hung, Robert Smith, Chia-Chin Lin
CONTEXT: Stroke is the second leading cause of death and the primary cause of disability worldwide. It is uncertain what care patients with stroke receive in their end of life care and what trends in care are in recent years. OBJECTIVES: To investigate the changes in the use of intensive and supportive procedures received by Taiwanese stroke patients in their last month of life during 2000-2010. METHODS: Analysis of claims data of 55,930 patients with stroke obtained from the National Health Insurance Research Database were performed to investigate the changes in the use of intensive and supportive procedures for Taiwanese stroke patients in their last month of life during 2000-2010...
November 27, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29171247/care-of-patients-undergoing-weaning-from-mechanical-ventilation-in-critical-care
#10
Susan Elliott, Nicola Morrell-Scott
There are several reasons why mechanical ventilation - the use of an artificial device to assist a patient to breathe - may be initiated, for example to enable general anaesthesia for patients undergoing surgery, and for those with a compromised airway or respiratory failure. It is important that critical care nurses have the skills and knowledge to care for patients who are undergoing weaning from mechanical ventilation. This is to ensure that patients are weaned safely and as soon as possible, to improve their outcomes and avoid an increase in patient mortality and morbidity through complications that can arise such as airway trauma and ventilator-associated pneumonia...
November 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/29159065/train-of-four-stimulation-artifact-mimicking-a-seizure-during-computerized-automated-icu-eeg-monitoring
#11
Laxmi P Dhakal, William O Tatum, William D Freeman
A 54-year-old man was admitted to the intensive care unit with an aneurysmal subarachnoid hemorrhage and subsequently underwent mechanical ventilation and received neuromuscular blocking drugs to control refractory elevated intracranial pressure. During quantitative EEG monitoring, an automated alert was triggered by the train of four peripheral nerve stimulation artifacts. Real-time feedback was made possible due to remote monitoring. This case illustrates how computerized, automated artificial intelligence algorithms can be used beyond typical seizure detection in the intensive care unit for remote monitoring to benefit patient care...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29156917/advance-care-planning-for-patients-with-advanced-neurology-diseases
#12
Ka-Chi Cheung, Vikki Wai-Kee Lau, Ka-Chun Un, Man-Sheung Wong, Kwok-Ying Chan
BACKGROUND: Advanced neurology diseases including motor neuron disease (MND) are usually progressive life-limiting illness and could be devastating for patients, families and caregivers. Although medical technologies, such as enteral feeding and non-invasive ventilation, may prolong life expectancy of the patients, their utilization prompts important ethical questions in regard to their quality of life (QoL). Little attention had been paid on how ACP practice would practically help with patients suffering from different neurology diseases...
October 13, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29148150/pressure-flow-characteristics-of-breathing-systems-and-their-components-for-pediatric-and-adult-patients
#13
Christin Wenzel, Stefan Schumann, Johannes Spaeth
BACKGROUND: Breathing circuits connect the ventilator to the patients' respiratory system. Breathing tubes, connectors, and sensors contribute to artificial airway resistance to a varying extent. We hypothesized that the flow-dependent resistance is higher in pediatric breathing systems and their components compared to respective types for adults. AIMS: We aimed to characterize the resistance of representative breathing systems and their components used in pediatric patients (including devices for adults) by their nonlinear pressure-flow relationship...
November 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29123883/delayed-autonomic-neuropathy-in-a-patient-with-diethylene-glycol-poisoning-a-case-report
#14
Hiroki Kamada, Hideaki Suzuki, Saori Yamamoto, Ryosuke Nomura, Shigeki Kushimoto
Case: A 72-year-old man presented to our hospital after ingesting insecticide containing approximately 2 mL/kg diethylene glycol, which exceeded the lethal dose of 1 mL/kg. The patient recovered from critical symptoms on acute phase until day 3, but received artificial ventilation for muscle weakness secondary to sensorimotor neuropathy on days 11-54. Outcome: Even after marked improvement from sensorimotor neuropathy, the patient continued to complain of orthostatic hypotension...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29123846/two-cases-of-cryptogenic-life-threatening-hemoptysis-identification-and-management-of-bleeding-point
#15
Kazunori Okuda, Jun Tanaka, Jun Okamoto, Fumihisa Kishi, Junichiro Nakagawa, Hiroshi Hino, Satoru Chujoh, Kazuhisa Shimadzu, Masafumi Kishimoto, Noboru Kato, Shigeru Shiono
Cases: Case 1: A 63-year-old woman was referred for coughing blood. Although cardiorespiratory dynamics were stabilized by artificial respiration under sedation, severely poor ventilation developed from asphyxia associated with massive respiratory tract hemorrhage. One-lung ventilation was temporarily secured by endotracheal tube insertion into the left main bronchus just prior to cardiopulmonary arrest.Case 2: A 72-year-old man was referred for massive hemoptysis after coughing, then intubated and placed on a respirator...
January 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29119398/myocardial-protection-against-ischemic-and-reperfusion-injuries-experimental-study
#16
I A Mandel', A Yu Podoksenov, I V Sukhodolo, Yu K Podoksenov, Yu S Svirko, N O Kamenshchikov, S L Mikheev, A S Sementsov, Yu V Rogovskaya, D A An, V M Shipulin, L N Maslov
The effects of hypoxic, hyperoxic, and hypoxic-hyperoxic preconditioning were examined in the prospective study on narcotized and artificially ventilated rabbits. Under artificial circulation, acute myocardial ischemia was modeled by ligation of anterior descending coronary artery, which was followed by reperfusion. The degree of ventricular arrhythmias was assessed, and the ischemic area was evaluated in percent of the area at risk. Microscopic characterization of the myocardium was employed to assess the cardioprotective effect of hypoxic and/or hyperoxic preconditioning...
November 9, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29099427/artificial-ventilation-a-basic-clinical-guide
#17
Gaetano Perchiazzi
No abstract text is available yet for this article.
November 1, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29096852/therapeutic-plasma-exchange-in-a-rare-case-myasthenic-crisis-after-botox-injection
#18
Azita Chegini
BACKGROUND AND AIMS: Botulinum toxin (Botox) injections are used as a cosmetic treatment to decrease wrinkles in face and chin. Being a neurotoxic agent it minimizes muscle activity, while side effects are usually rare. This article subsequently presents one case of these rare effects. CASE: A 30-year-old woman presenting with ptosis, diplopia, dysarthria, dysphagia and muscle weakness was admitted to our hospital. She had no history of disease. For cosmetic reasons, she had three Botox injections during the preceding months...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29076469/-use-of-the-intellivent-asv-mode-for-maintaining-the-target-etco2-range-in-patients-with-severe-tbi
#19
E P Anan'ev, A A Polupan, I V Matskovskiy, A V Oshorov, A S Goryachev, I A Savin, A A Sychev, T F Tabasaranskiy, V V Podlepich, K Yu Krylov, A A Pashin, O E Satishur, L Piquilloud, D Novotni, A A Potapov, Ya V Savchenko
PURPOSE: the study purpose was to evaluate the efficacy of the IntelliVent-ASV mode in maintaining the target range of PaCO2 in patients with severe TBI. MATERIAL AND METHODS: The study included 12 severe TBI patients with the wakefulness level scored 4-9 (GCS). This was a crossover design study. Two ventilation modes were consecutively used: IntelliVent-ASV and P-CMV, for 12 h each. When using the P-CMV mode, the ventilation parameters were set to maintain PaCO2 in a range of 35-38 mm Hg...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29060013/temperature-influence-on-the-response-at-low-airflow-of-a-variable-orifice-flowmeter
#20
C Massaroni, E Schena, S Silvestri
In mechanical ventilation, in particular when neonates are ventilated, it is crucial to accurately control the amount of the gas delivered to the patients. Mechanical ventilators are equipped with one of more flowmeters. The signal of the flowmeter is used as feedback to control the amount of gas delivered to the patients. Therefore, the accuracy of the flowmeter plays a crucial role in the accurate adjustment of the gas amount delivered by the ventilator. Among several solutions, variable area orifice meters (VAOMs) have several valuable features (e...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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