Linjie Li, Shuanghui Yin, Jingjing Zhou, Liping Zhang, Zhidong Teng, Lu Qiao, Yunhang Wang, Jiaxi Yu, Haoyue Zang, Yaozhong Ding, Xinsheng Liu, Shiqi Sun, Huichen Guo
Porcine epidemic diarrhea virus (PEDV) is considered the cause for porcine epidemic diarrhea (PED) outbreaks and hefty losses in pig farming. However, no effective commercial vaccines against PEDV mutant strains are available nowadays. Here, we constructed three native-like trimeric candidate nanovaccines, i.e., spike 1 trimer (S1-Trimer), collagenase equivalent domain trimer (COE-Trimer), and receptor-binding domain trimer (RBD-Trimer) for PEDV based on Trimer-Tag technology. And evaluated its physical properties and immune efficacy...
2024: Frontiers in Microbiology