keyword
MENU ▼
Read by QxMD icon Read
search

pediatrics liquids

keyword
https://www.readbyqxmd.com/read/29752842/correlation-between-duration-of-preoperative-fasting-and-emergence-delirium-in-pediatric-patients-undergoing-ophthalmic-examination-under-anesthesia-a-prospective-observational-study
#1
Puneet Khanna, Kulbhushan Saini, Renu Sinha, Niseville Nisa, Shailendra Kumar, Souvik Maitra
BACKGROUND: Preoperative fasting in children can cause anxiety, which may ultimately lead to postoperative emergence delirium. However, no data are available whether duration of preoperative fasting correlates with postoperative emergence delirium. AIMS: The aim of this study was to identify if there is any correlation between the duration of preoperative fasting and emergence delirium in children undergoing ophthalmic examination under anesthesia. METHODS: In this prospective observational study, 100 children between the age group 2-6 years of American Society of Anesthesiologists physical status I or II, scheduled for examination of the eye under general anesthesia with sevoflurane were recruited...
May 12, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29733506/a-comparison-of-intraoperative-hemostatic-techniques-during-tonsillectomy-suture-versus-electrocautery-a-study-to-assess-post-operative-pain-scores-and-duration-to-resumption-of-normal-diet
#2
Michele Cassano, Nuray Bayar Muluk, Francesco Di Taranto, Somasundaram Subramaniam
OBJECTIVES: To assess postoperative pain and pattern of recovery to normal diet in children who underwent tonsillectomy. METHODS: Cold steel tonsillectomy (or adenotonsillectomy) was performed in 61 children. Hemostasis was attained with sutures in Group 1 (n=30, 8 tonsillectomy and 22 adenotonsillectomy), and electrocautery in Group 2 (n=31,6 tonsillectomy and 25 adenotonsillectomy). Information obtained included post-operative pain scores and the number of postoperative days taken to resume normal diet...
May 7, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29732920/replacing-liquid-antibiotics-with-cheaper-pill-equivalents-an-opportunity-for-substantial-savings
#3
Kristen S Hori, Andrea M Siu, Loren G Yamamoto
Liquid antibiotics are often substantially more expensive than their pill counterparts, representing an opportunity for substantial cost reductions. Children can be taught to swallow pills at about age 6 years. The objective of this study was to calculate the potential cost saved by replacing liquid antibiotics with cheaper pill equivalents for pediatric patients for the antibiotic prescriptions written by a health care system. A retrospective smart cost analysis was performed of pediatric patients within a health care system, age 6 to less than 18 years of age receiving a liquid antibiotic prescription...
May 1, 2018: Clinical Pediatrics
https://www.readbyqxmd.com/read/29731315/multiple-neurosurgical-treatments-for-different-members-of-the-same-family-with-currarino-syndrome
#4
N Serratrice, L Fievet, F Albader, D Scavarda, H Dufour, S Fuentes
INTRODUCTION: Currarino's syndrome (CS) is an autosomal dominant disorder of embryonic development causing a rare malformating syndrome characterized by a triad of an anorectal malformations, presacral mass (most commonly an anterior sacral meningocele) and sacral bony defects. Mutations of the HLXB9 gene have been identified in most CS cases, but a precise genotype-phenotype correlation has not been described so far. Family screening is obligatory. The diagnosis is usually made during childhood and rarely in adulthood...
May 3, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29730093/adverse-events-and-satisfaction-with-use-of-intranasal-midazolam-for-emergency-department-procedures-in-children
#5
Laurie Malia, V Matt Laurich, Jesse J Sturm
PURPOSE: Procedural sedation is commonly performed in the emergency department (ED). Having safe and fast means of providing sedation and anxiolysis to children is important for the child's tolerance of the procedure, parent satisfaction and efficient patient flow in the ED. OBJECTIVE: To evaluate fasting times associated with the administration of intranasal midazolam (INM) and associated complications. Secondary objectives included assessing provider and caregiver satisfaction scores...
April 30, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29713143/population-pharmacokinetics-and-dosing-optimization-of-cefathiamidine-in-children-with-hematologic-infection
#6
Li-Juan Zhi, Li Wang, Xing-Kai Chen, Xiao-Ying Zhai, Li Wen, Lei Dong, Evelyne Jacqz-Aigrain, Zhong-Ren Shi, Wei Zhao
Purpose: Cefathiamidine, a first-generation cephalosporin, has approval from the China Food and Drug Administration for the treatment of infections caused by susceptible bacteria in both adults and children. As pharmacokinetic data are limited in the pediatric population, we aimed to evaluate the population pharmacokinetics of cefathiamidine in children and to define the appropriate dose in order to optimize cefathiamidine treatment. Methods: Blood samples were collected from children treated with cefathiamidine, and concentrations were quantified by high-performance liquid chromatography and tandem mass spectrometry...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29694956/multiples-of-median-transformed-normalized-reference-ranges-of-steroid-profiling-data-independent-of-age-sex-and-units
#7
Dominika Zalas, Thomas Reinehr, Marek Niedziela, Christoph Borzikowsky, Maciej Flader, Gunter Simic-Schleicher, Halit Ilker Akkurt, Sabine Heger, Nadine Hornig, Paul-Martin Holterhus, Alexandra E Kulle
BACKGROUND/AIMS: The high complexity of pediatric reference ranges across age, sex, and units impairs clinical application and comparability of steroid hormone data, e.g., in congenital adrenal hyperplasia (CAH). We developed a multiples-of-median (MoM) normalization tool to overcome this major drawback in pediatric endocrinology. METHODS: Liquid chromatography tandem mass spectrometry data comprising 10 steroid hormones representing 905 controls (555 males, 350 females, 0 to > 16 years) from 2 previous datasets were MoM transformed across age and sex...
April 25, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29691266/stability-of-extemporaneously-prepared-ophthalmic-solutions-for-mydriasis
#8
Nicole A Camp, Jennifer T Nadra, Susan E Hughes, Justine M Gilbert, Fang Zhao
PURPOSE: Results of an evaluation of the physical and chemical stability of extemporaneously prepared adult and pediatric ophthalmic solutions containing combinations of phenylephrine, tropicamide, and cyclopentolate are reported. METHODS: A stability study was conducted to help determine the feasibility of innovative formulations to meet an unmet clinical need for combination mydriatic ophthalmic eyedrops. An adult mydriatic ophthalmic solution containing phenylephrine hydrochloride 2...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29686144/e-cigarette-and-liquid-nicotine-exposures-among-young-children
#9
Preethi Govindarajan, Henry A Spiller, Marcel J Casavant, Thitphalak Chounthirath, Gary A Smith
OBJECTIVES: To investigate exposures to liquid nicotine (including electronic cigarette devices and liquids) among children <6 years old in the United States and evaluate the impact of legislation requiring child-resistant packaging for liquid nicotine containers. METHODS: Liquid nicotine exposure data from the National Poison Data System for January 2012 through April 2017 were analyzed. RESULTS: There were 8269 liquid nicotine exposures among children <6 years old reported to US poison control centers during the study period...
April 23, 2018: Pediatrics
https://www.readbyqxmd.com/read/29679555/mass-spectrometric-measurement-of-urinary-kynurenine-to-tryptophan-ratio-in-children-with-and-without-urinary-tract-infection
#10
Melanie L Yarbrough, Kelleigh E Briden, John V Mitsios, Annette L Weindel, Cindy M Terrill, David A Hunstad, Dennis J Dietzen
BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) catalyzes the first step of tryptophan (Trp) catabolism, yielding kynurenine (Kyn) metabolites. The kynurenine-to-tryptophan (K/T) ratio is used as a surrogate for biological IDO enzyme activity. IDO expression is increased during Escherichia coli urinary tract infection (UTI). Thus, our objective was to develop a method for measurement of Kyn/Trp ratio in human blood and urine and evaluate its use as a biomarker of UTI. METHODS: A mass spectrometric method was developed to measure Trp and Kyn in serum and urine specimens...
April 18, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29673417/vitamin-b-12-cyanocobalamin-in-infant-formula-adult-pediatric-nutritional-formula-by-liquid-chromatography-with-ultraviolet-detection-collaborative-study-final-action-2014-02
#11
Ester Campos Giménez, Frédéric Martin
To determine the repeatability and reproducibility figures of the AOAC First Action Official Method SM 2014.02 ( Vitamin B12 in Infant Formula and Adult/Pediatric Formula by Liquid Chromatography with UV Detection ), a collaborative study was organized. Twenty-one laboratories located in 13 different countries agreed to participate. The study was divided into two parts. During the first part, the laboratories analyzed two samples in duplicate by using the method described in the protocol. The laboratories that provided results within the expected range were qualified for part two, during which they analyzed 10 samples in blind duplicates...
April 19, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/29664690/methadone-as-the-initial-long-acting-opioid-in-children-with-advanced-cancer
#12
Kevin Madden, Sarah Mills, Seyedeh Dibaj, Janet L Williams, Diane Liu, Eduardo Bruera
BACKGROUND: Methadone is an attractive medication for treating children with advanced cancer with pain as it is the only long-acting opioid available as a liquid. However, it is not frequently used due to concerns about potential toxicities and side effects. OBJECTIVE: Evaluate the efficacy and safety of methadone as the first long-acting opioid in children with advanced cancer. DESIGN: Retrospective chart review of 52 consecutive patients referred to Pediatric Supportive Care for pain management started on methadone as their first long-acting opioid...
April 17, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29622340/frequency-of-poison-center-exposures-for-pediatric-accidental-unsupervised-ingestions-of-acetaminophen-after-the-introduction-of-flow-restrictors
#13
Eric P Brass, Kate M Reynolds, Randy I Burnham, Jody L Green
OBJECTIVE: To assess the temporal association of flow restrictor introduction and the rate of accidental unsupervised ingestions (AUIs) of liquid acetaminophen products. STUDY DESIGN: The National Poison Data System was used to identify AUIs of single ingredient acetaminophen in patients aged <12 years reported between 2007 and 2015. Six regional poison centers obtained additional information using a structured telephone survey. RESULTS: Pediatric AUIs involving acetaminophen averaged 30 000 exposures per year between 2007 and 2012...
April 2, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29615816/distinct-metabolic-features-differentiating-flt3-itd-aml-from-flt3-wt-childhood-acute-myeloid-leukemia
#14
Bradley Stockard, Timothy Garrett, Joy Guingab-Cagmat, Soheil Meshinchi, Jatinder Lamba
Acute myeloid leukemia (AML) is a heterogeneous disease with dismal response warranting the need for enhancing our understanding of AML biology. One prognostic feature associated with inferior response is the presence of activating mutations in FMS-like tyrosine kinase 3 (FLT3) especially occurrence of internal tandem duplication (FLT3-ITD). Although poorly understood, differential metabolic and signaling pathways associated with FLT3-ITD might contribute towards the observed poor prognosis. We performed a non-targeted global metabolic profiling of matched cell and plasma samples obtained at diagnosis to establish metabolic differences within FLT3-ITD and FLT3-WT pediatric AML...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29603083/first-development-optimization-and-stability-control-of-a-pediatric-oral-atenolol-formulation
#15
Mauro Morri, Patricia Castellano, Darío Leonardi, Silvana Vignaduzzo
Liquid formulations can be used in children of different ages by varying the volume of the administered dose in order to ensure an exact dosage. The aim of this work was to develop and to optimize a safe liquid atenolol formulation and to carry out the corresponding chemical and microbiological stability studies. A Plackett-Burman design was used to determine the factors that could be critical in the development of the formulations, and a central composite design was used to determine the optimal working conditions...
May 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29595531/sedative-and-analgesic-drug-sequestration-after-a-single-bolus-injection-in-an-ex-vivo-extracorporeal-membrane-oxygenation-infant-circuit
#16
Viviane G Nasr, Jonathan Meserve, Luis M Pereira, David Faraoni, Steve Brediger, Susan Goobie, Ravi Thiagarajan, James A DiNardo
Patient sedation and analgesia on extracorporeal membrane oxygenation (ECMO) is vital for safety and comfort. However, adsorption to the circuit may alter drug pharmacokinetics and remains poorly characterized. This study characterizes drug adsorption of morphine, fentanyl, midazolam, and dexmedetomidine in an ex vivo infant ECMO circuit utilizing polymethylpentene (PMP) membrane oxygenator (MO) with protein-bounded polyvinylchloride (PVC) tubing. Twelve closed-loop ex vivo ECMO circuits were prepared using P...
March 26, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29551449/mortality-risk-factors-in-war-related-pediatric-burns-a-comparative-study-among-two-distinct-populations
#17
Sevgi Buyukbese Sarsu, Aydin Budeyri
INTRODUCTION: Previously, the majority of wars were fought on remote battlefields between opposing armies due to conflicts preventing civilians from sustaining war-related burn injuries (WRBI). In recent years, WRBI has had a tremendous harmful impact on the pediatric population. This study aimed to investigate the demographics, causes, mechanisms of burns, surgical procedures, the major and minor risk factors affecting mortality, and outcomes of pediatric WRBI amidst the Syrian refugees and the Turkey neighborhood population, treated at our Burn Center...
March 15, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29551448/poverty-population-density-and-the-epidemiology-of-burns-in-young-children-from-mexico-treated-at-a-u-s-pediatric-burn-facility
#18
Dipen D Patel, Marta Rosenberg, Laura Rosenberg, Guillermo Foncerrada, Clark R Andersen, Karel D Capek, Jesus Leal, Jong O Lee, Carlos Jimenez, Ludwik Branski, Walter J Meyer, David N Herndon
INTRODUCTION: Children 5 and younger are at risk for sustaining serious burn injuries. The causes of burns vary depending on demographic, cultural and socioeconomic variables. At this pediatric burn center we provided medical care to children from Mexico with severe injuries. The purpose of this study was to understand the impact of demographic distribution and modifiable risk factors of burns in young children to help guide prevention. METHODS: A retrospective chart review was performed with children 5 and younger from Mexico who were injured from 2000-2013...
March 7, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29547456/morphine-pharmacokinetics-in-children-with-down-syndrome-following-cardiac-surgery
#19
Benjamin H Goot, Jon Kaufman, Zhaoxing Pan, David W A Bourne, Francis Hickey, Mark Twite, Jeffrey Galinkin, Uwe Christians, Jeannie Zuk, Eduardo M da Cruz
OBJECTIVES: To assess if morphine pharmacokinetics are different in children with Down syndrome when compared with children without Down syndrome. DESIGN: Prospective single-center study including subjects with Down syndrome undergoing cardiac surgery (neonate to 18 yr old) matched by age and cardiac lesion with non-Down syndrome controls. Subjects were placed on a postoperative morphine infusion that was adjusted as clinically necessary, and blood was sampled to measure morphine and its metabolites concentrations...
May 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29533950/gut-microbiota-dysbiosis-in-children-with-relapsing-idiopathic-nephrotic-syndrome
#20
Shoji Tsuji, Chikushi Suruda, Masaki Hashiyada, Takahisa Kimata, Sohsaku Yamanouchi, Tetsuya Kitao, Jiro Kino, Atsushi Akane, Kazunari Kaneko
BACKGROUND: While the etiology of idiopathic nephrotic syndrome (idiopathic nephrotic syndrome [INS]; characterized by repeated relapses and comorbid allergic conditions) remains unknown, recent evidence suggests that dysfunction in regulatory T cells (Tregs) plays an important role in the development of INS as well as allergic diseases. We hypothesized that dysbiosis involving decreased butyric acid-producing gut microbiota leads to defective induction and differentiation of peripherally induced Tregs, resulting in INS relapse...
2018: American Journal of Nephrology
keyword
keyword
46880
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"