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https://www.readbyqxmd.com/read/28098395/first-uhplc-ms-ms-method-coupled-with-automated-on-line-spe-for-quantification-both-of-tacrolimus-and-everolimus-in-peripheral-blood-mononuclear-cells-and-its-application-on-samples-from-co-treated-pediatric-patients
#1
Debora Pensi, Amedeo De Nicolò, Michele Pinon, Clarissa Pisciotta, Pier Luigi Calvo, Antonello Nonnato, Renato Romagnoli, Francesco Tandoi, Giovanni Di Perri, Antonio D'Avolio
Tacrolimus (TAC, FK-506) and everolimus (EVE, RAD001) are immunosuppressors used to treat pediatric patients undergoing liver transplantation. Their hematic TDM by liquid chromatography became standard practice. However, it does not always reflect concentrations at their active site. Our aim was to develop and validate a new method for the simultaneous TAC and EVE quantification into target cells: Peripheral-Blood-Mononuclear-Cells (PBMCs). PBMCs were collected using Cell-Preparation-Tubes; cells number and MCV were evaluated by an automatic cell counter...
January 18, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28074348/challenges-and-opportunities-in-the-development-of-hiv-medications-in-pediatric-patients
#2
Gueorgui Dubrocq, Natella Rakhmanina, B Ryan Phelps
Successful management of pediatric HIV disease requires high therapeutic efficacy and adherence, which can be achieved by providing affordable, easy to store, and palatable antiretrovirals. Current challenges in pediatric antiretroviral drug development include poor palatability, large pill size, limited oral liquid formulations, and few incentives for development by drug manufacturers as the number of children with HIV continues to decline due to successful worldwide preventive interventions and improved access to antiretrovirals...
January 10, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28040557/measurement-of-pyridoxal-5-phosphate-pyridoxal-and-4-pyridoxic-acid-in-the-cerebrospinal-fluid-of-children
#3
Tomoyuki Akiyama, Mari Akiyama, Yumiko Hayashi, Takashi Shibata, Yoshiyuki Hanaoka, Soichiro Toda, Katsumi Imai, Shin-Ichiro Hamano, Tohru Okanishi, Harumi Yoshinaga, Katsuhiro Kobayashi
BACKGROUND: We quantified pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in the cerebrospinal fluid (CSF) of children and to investigate the effect of age, sex, epilepsy, and anti-epileptic drug (AED) therapy on these vitamers. METHODS: CSF samples prospectively collected from 116 pediatric patients were analyzed. PLP, PL, and PA were measured using high-performance liquid chromatography with fluorescence detection, using pre-column derivatization by semicarbazide...
December 28, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28028334/liquid-based-versus-conventional-cytology-in-solid-pediatric-neoplasm-comparison-of-their-diagnostic-and-morphological-spectra
#4
Preeti Agarwal, Sunita Yadav, Archana Kumar, Madhu M Goel
BACKGROUND: Conventional cytology (CC) is a well-established and effective methodology for the evaluation of pediatric tumors. Liquid-based cytology (LBC) is a better technique of smear preparation and is at present the standard protocol in cervical cytology samples. AIMS: In the present study, we analyzed both smear preparatory techniques in fine-needle aspiration (FNA) samples from solid pediatric neoplasms in terms of adequacy and efficacy with objectives to study the changes in background and morphology of tumor cells in LBC smears...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27988056/unintentional-pediatric-ingestion-of-electronic%C3%A2-cigarette-nicotine-refill-liquid-necessitating-intubation
#5
Matthew J Noble, Beck Longstreet, Robert G Hendrickson, Roy Gerona
Liquid nicotine used in electronic cigarette devices is highly concentrated, unreliably packaged, and poorly regulated. We present a case report of a 6-year-old female who developed severe toxicity and required intubation after an unintentional oral ingestion of approximately 703 mg (35 mg/kg) of liquid nicotine, with accompanying serum and urine concentrations of nicotine and its metabolites. Analysis of the ingested liquid suggests a nicotine concentration of 140.6 mg/mL in the purchased commercial product, or 234% of its labeled concentration...
January 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27987364/effect-of-the-polymorphism-of-folylpolyglutamate-synthetase-on-treatment-of-high-dose-methotrexate-in-pediatric-patients-with-acute-lymphocytic-leukemia
#6
Zhen Huang, Hong-Fei Tong, Yuan Li, Jiang-Chao Qian, Ju-Xiang Wang, Zhe Wang, Ji-Chen Ruan
BACKGROUND The aim of this study was to investigate the association of the polymorphism of folylpolyglutamate synthetase (FPGS) with the dynamic plasma concentration of methotrexate (MTX) in pediatric patients with acute lymphocytic leukemia (ALL), as well as the prognosis. MATERIAL AND METHODS 57 ALL patients and 31 age and sex-matched children (control) were included in this study. Polymerase chain reaction-restriction fragment length polymorphism was performed for the analysis of the genotype of FPGS rs1544105 and high-performance liquid chromatography for measurement of MTX plasma concentration after 24-h and 44-h treatment...
December 17, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27977534/acute-mercury-poisoning-in-a-group-of-school-children
#7
Olcay Güngör, Ahmet Kağan Özkaya, Serkan Kirik, Tahir Dalkiran, Gülay Güngör, Sedat Işikay, Mehmet Davutoğlu, Cengiz Dilber
OBJECTIVE: Elemental mercury is a toxic liquid element that is used widely in the home, medicine, agriculture, and industry. It is readily vaporized and inhaled at room temperature. Thereby, inhalation can cause acute or chronic poisoning. Mercury can be found in environmental naturally find but some dangers sources give rise to contaminations. It can be very dangerous to all living organisms, especially children. METHODS: This study presents the features of mercury poisoning in a group of pediatric cases...
December 12, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27973472/in-vitro-and-in-vivo-comparison-between-poractant-alfa-and-the-new-generation-synthetic-surfactant-chf5633
#8
Francesca Ricci, Xabier Murgia, Roberta Razzetti, Nicola Pelizzi, Fabrizio Salomone
BACKGROUND: CHF5633 is a new generation synthetic surfactant containing both SP-B and SP-C analogues developed for the treatment of respiratory distress syndrome. Here, the optimal dose and its performance in comparison to the animal-derived surfactant poractant alfa were investigated. METHODS: In vitro surfactant activity was determined by means of the Wilhelmy balance and the capillary surfactometer. The dose-finding study was performed in preterm rabbits with severe surfactant deficiency...
December 14, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27966809/delayed-elimination-of-high-dose-methotrexate-and-use-of-carboxypeptidase-g2-in-pediatric-patients-during-treatment-for-acute-lymphoblastic-leukemia
#9
Thommy Svahn, Karin Mellgren, Arja Harila-Saari, Ann Åsberg, Jukka Kanerva, Ólafur Jónsson, Goda Vaitkeviciene, Torben Stamm Mikkelssen, Kjeld Schmiegelow, Jesper Heldrup
BACKGROUND: Carboxypeptidase G2 (CPDG2 ) can be used as rescue treatment in cases of delayed methotrexate elimination (DME) and Mtx-induced nephrotoxicity. PROCEDURE: Between July 2008 and December 2014, all children (1.0-17.9 years) in the Nordic countries diagnosed with Philadelphia chromosome negative acute lymphoblastic leukemia (ALL) were treated according to the Nordic Organization for Pediatric Hematology and Oncology (NOPHO) ALL 2008 protocol, including administration of six to eight high-dose (5 g/m(2) /24 hr) Mtx (HDMtx) courses...
December 14, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27956421/pharmacokinetics-of-miltefosine-in-children-and-adults-with-cutaneous-leishmaniasis
#10
María Del Mar Castro, Maria Adelaida Gomez, Anke E Kip, Alexandra Cossio, Eduardo Ortiz, Adriana Navas, Thomas P C Dorlo, Nancy Gore Saravia
AIMS AND DESIGN: An open label, pharmacokinetics clinical trial was conducted to comparatively assess the pharmacokinetics (PK) and explore the pharmacodynamics (PD) of miltefosine in children and adults with cutaneous leishmaniasis in Colombia. METHODS: Sixty patients, 30 children aged 2-12 years and 30 adults aged 18-60 years were enrolled. Participants received miltefosine (Impavido®) at a nominal dose of 2.5 mg/kg/day for 28 days. Miltefosine concentrations were measured in plasma and peripheral blood mononuclear cells by liquid chromatography tandem-mass spectrometry of samples obtained during treatment and up to six months following completion of treatment, when therapeutic outcome was determined...
December 12, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27956094/gastrointestinal-transit-scintigraphy-in-chronic-constipation-evaluation-in-pediatric-age-an-infrequent-test
#11
J R Infante, J I Rayo, J Serrano, L García, M Moreno, A Martínez, J Huertas
AIM: Chronic constipation is a common pathology in children. The aim of this paper was to show the usefulness of gastrointestinal transit scintigraphy in pediatric patients with chronic constipation, and the advantages with respect to other imaging techniques, despite our limited experience. MATERIAL AND METHODS: We evaluated 5 patients sent to our service with a diagnosis of chronic constipation refractory to treatment. We performed a complete study protocol, including liquid gastric emptying scintigraphy and small and large bowel transit times, using a single dose of (111)In-DTPA...
December 9, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27940673/can-a-flavored-spray-pill-glide-help-children-swallow-their-medicines-a-pilot-study
#12
Mamta Jagani, Hélène Legay, Sejal R Ranmal, Julie Bertrand, Kuan Ooi, Catherine Tuleu
Pediatric pharmacists are constantly faced with the challenges of supporting children and caregivers for whom the difficulties of swallowing medicines can be a daily struggle. Most medicines are only available as tablets and capsules, and where liquid alternatives exist, these products often have issues with palatability and high costs. The objective of this study was to evaluate whether the swallowing spray, Pill Glide, could help children in taking their solid and liquid medicines. This open label pilot study compared the spray with a behavioral approach alone, the current standard of care at the pediatric hospital...
December 2016: Pediatrics
https://www.readbyqxmd.com/read/27940130/simultaneous-measurement-of-monoamine-metabolites-and-5-methyltetrahydrofolate-in-the-cerebrospinal-fluid-of-children
#13
Tomoyuki Akiyama, Yumiko Hayashi, Yoshiyuki Hanaoka, Takashi Shibata, Mari Akiyama, Kazuyuki Nakamura, Yu Tsuyusaki, Masaya Kubota, Harumi Yoshinaga, Katsuhiro Kobayashi
BACKGROUND: We describe a new method for simultaneous measurement of monoamine metabolites (3-O-methyldopa [3-OMD], 3-methoxy-4-hydroxyphenylethyleneglycol [MHPG], 5-hydroxyindoleacetic acid [5-HIAA], and homovanillic acid [HVA]) and 5-methyltetrahydrofolate (5-MTHF) and its use on cerebrospinal fluid (CSF) samples from pediatric patients. METHODS: Monoamine metabolites and 5-MTHF were measured by high-performance liquid chromatography with fluorescence detection...
December 7, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27855062/safety-tolerability-and-pharmacokinetics-of-liposomal-amphotericin-b-in-immunocompromised-pediatric-patients
#14
Nita L Seibel, Aziza T Shad, Ihor Bekersky, Andreas H Groll, Corina Gonzalez, Lauren V Wood, Paul Jarosinski, Donald Buell, William W Hope, Thomas J Walsh
The safety, tolerability and pharmacokinetics of liposomal formulation of amphotericin B (L-AMB) were evaluated in 40 immunocompromised children and adolescents. The protocol was an open-label, sequential-dose-escalation, multidose pharmacokinetic study with 10 to 13 patients in each of the four dosage cohorts. Each cohort received daily dosages of 2.5, 5.0, 7.5 or 10 mg of amphotericin B in the form of L-AMB per kg of body weight. Neutropenic patients between ages 1 and 17 years were enrolled to receive empirical antifungal therapy or treatment of documented invasive fungal infections...
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27853293/association-of-arsenic-methylation-capacity-with-developmental-delays-and-health-status-in-children-a-prospective-case-control-trial
#15
Yu-Mei Hsueh, Wei-Jen Chen, Chih-Ying Lee, Ssu-Ning Chien, Horng-Sheng Shiue, Shiau-Rung Huang, Ming-I Lin, Shu-Chi Mu, Ru-Lan Hsieh
This case-control study identified the association between the arsenic methylation capacity and developmental delays and explored the association of this capacity with the health status of children. We recruited 120 children with developmental delays and 120 age- and sex-matched children without developmental delays. The health status of the children was assessed using the Pediatric Quality of Life Inventory (PedsQL) and Pediatric Outcomes Data Collection Instrument (PODCI). The arsenic methylation capacity was determined by the percentages of inorganic arsenic (InAs%), monomethylarsonic acid (MMA(V)%), and dimethylarsinic acid (DMA(V)%) through liquid chromatography and hydride generation atomic absorption spectrometry...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27846055/a-phase-iii-randomized-double-blind-clinical-trial-of-an-investigational-hexavalent-vaccine-given-at-2-3-4-and-12-months
#16
Timo Vesikari, Thomas Becker, Andre F Vertruyen, Katleen Poschet, Sheryl A Flores, Marco F Pagnoni, Jin Xu, G Frank Liu, Jon E Stek, Florence Boisnard, Stéphane Thomas, Eddy Ziani, Andrew W Lee
BACKGROUND: Combination vaccines simplify vaccination visits and improve coverage and timeliness. DTaP5-HB-IPV-Hib is a new investigational, fully-liquid, combination vaccine containing a 5-antigen pertussis component and which is designed to protect against 6 infectious diseases. METHODS: In this multicenter, double-blind, comparator-controlled, Phase III study (NCT01341639) conducted in Finland, Germany, and Belgium, healthy infants were randomized 1:1 to receive one of two immunization regimens...
November 11, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27822783/intraoperative-temperature-regulation-in-children-using-a-liquid-warming-garment
#17
Mariya E Skube, Robert D Acton, Victor S Koscheyev, Gloria R Leon, Daniel A Saltzman
PURPOSE: Children undergoing operative intervention while induced under general anesthesia are at risk for experiencing a significant decrease in core body temperature that can lead to adverse systemic effects. Given that the head contributes an estimated 18% of a child's body surface area, we theorized that a liquid-warming garment applied to the head could control a pediatric patient's core body temperature during surgical procedures. METHODS: Patients undergoing elective, non-cranial, general surgical procedures were enrolled in the study...
November 7, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27806590/a-scintillator-based-approach-to-monitor-secondary-neutron-production-during-proton-therapy
#18
S D Clarke, E Pryser, B M Wieger, S A Pozzi, R A Haelg, V A Bashkirov, R W Schulte
PURPOSE: The primary objective of this work is to measure the secondary neutron field produced by an uncollimated proton pencil beam impinging on different tissue-equivalent phantom materials using organic scintillation detectors. Additionally, the Monte Carlo code mcnpx-PoliMi was used to simulate the detector response for comparison to the measured data. Comparison of the measured and simulated data will validate this approach for monitoring secondary neutron dose during proton therapy...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27795647/erosive-effects-of-pediatric-liquid-medicinal-syrups-on-primary-enamel-an-in-vitro-comparative-study
#19
Parimala Kulkarni, Ayushi Anand, Arpana Bansal, Ankur Jain, Utkarsh Tiwari, Suchi Agrawal
CONTEXT: The use of liquid medicinal syrups in childhood is high owing to the reasons that children suffer from illness quite often. The acidic component in the formulations may cause erosion to the dental tissues. AIMS: The aim of this study is to evaluate the erosive potential of pediatric liquid medicinal syrups on the deciduous teeth. SUBJECTS AND METHODS: A total of sixty extracted/exfoliated noncarious deciduous molars were used. Four medical syrups were used (viz...
September 2016: Indian Journal of Dentistry
https://www.readbyqxmd.com/read/27786174/fecal-metabolomics-in-pediatric-spondyloarthritis-implicate-decreased-metabolic-diversity-and-altered-tryptophan-metabolism-as-pathogenic-factors
#20
M L Stoll, R Kumar, E J Lefkowitz, R Q Cron, C D Morrow, S Barnes
We have previously shown alterations in the composition of the gut microbiota in children with enthesitis-related arthritis (ERA). To explore the mechanisms by which an altered microbiota might predispose to arthritis, we performed metabolomic profiling of fecal samples of children with ERA. Fecal samples were collected from two cohorts of children with ERA and healthy control subjects. Nano-liquid chromatography-mass spectroscopy (LC-MS) was performed on the fecal water homogenates with identification based upon mass: charge ratios...
December 2016: Genes and Immunity
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