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https://www.readbyqxmd.com/read/28031170/the-influence-of-sex-on-hyperfiltration-in-patients-with-uncomplicated-type-1-diabetes
#1
Marko Škrtić, Yuliya Lytvyn, Petter Bjornstad, Heather N Reich, James W Scholey, Paul M Yip, Etienne B Sochett, Bruce A Perkins, David Z I Cherney
The aim of this analysis was to examine sex-based differences in renal segmental resistances in healthy controls (HC) and patients with type 1 diabetes (T1D). We hypothesized that hyperfiltration - an early hemodynamic abnormality associated with diabetic nephropathy (DN) - would disproportionately affect women with T1D, thereby attenuating protection against the development of renal complications. Glomerular hemodynamic parameters were evaluated in HC (n=30) and in normotensive, normoalbuminuric patients with T1D and either baseline normofiltration (n=36, T1D-N, glomerular filtration rate [GFR] 90-134 ml/min/1...
December 28, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28017667/assessment-of-optimal-initial-dosing-regimen-with-vancomycin-pharmacokinetics-model-in-very-low-birth-weight-neonates
#2
Hideo Kato, Mao Hagihara, Naoya Nishiyama, Yusuke Koizumi, Hiroshige Mikamo, Katsuhiko Matsuura, Yuka Yamagishi
INTRODUCTION: Pharmacokinetic of vancomycin in very low birth weight neonates showed big variety, and limited data were available due to very minor population. These facts make it difficult to adjust its optimal initial dosage. Therefore, this study was to develop optimal dosing regimen of vancomycin in very low birth weight neonates. METHODS: Between 2010 and 2015, low birth weight neonates (≤1500 g) were included in a population pharmacokinetics analysis. Based on the pharmacokinetic parameters we estimated, we simulated individual blood concentrations of vancomycin and evaluated the probability of its pharmacokinetics/pharmacodynamics (PK/PD) target attainment, such as 24-h area under the concentration-time curve (AUC24)/MIC (≥400) and blood trough concentration (10-20 μg/mL), as primary measure for several dosing regimens by Monte Carlo simulation method...
December 22, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27995288/nadolol-for-treatment-of-supraventricular-tachycardia-in-infants-and-young-children
#3
Johannes C von Alvensleben, Martin J LaPage, Regine Caruthers, David J Bradley
Supraventricular tachycardia (SVT) is a common infant arrhythmia, for which beta-blockers are frequently chosen as therapy. Propranolol is a common choice though it is dosed every 6-8 h. We reviewed the clinical results of treating infant SVT with an extemporaneous preparation of nadolol. Retrospective cohort study of patients under 2 years old receiving nadolol for SVT at a single center. Patients were ascertained by patient and pharmacy databases. Twenty-eight infants received nadolol, of whom 25 had regular narrow complex tachycardia, 2 atrial flutter, and 1 focal atrial tachycardia...
December 19, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27982453/trends-in-celecoxib-and-etoricoxib-prescribing-following-removal-of-prior-authorization-requirement-in-spain
#4
E Carracedo-Martínez, A Pia-Morandeira, A Figueiras
WHAT IS KNOWN AND OBJECTIVE: Previous studies indicate that the implementation of a prior authorization requirement for coxibs was followed by a sharp decline in their use. There are no studies showing what happens if coxib prior authorization is removed. The objective of this study is to assess the trend in the use of coxibs marketed in Spain, following removal of their respective prior authorization requirements in November 2006 for celecoxib and February 2007 for etoricoxib. METHODS: We calculated the monthly number of defined daily doses per thousand inhabitants per day (DDD/TID) of coxibs dispensed in a health area of Spain from mid-2005 to December 2007...
December 15, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27978532/ibuprofen-plus-paracetamol-versus-ibuprofen-in-acute-low-back-pain-a-randomized-open-label-multicenter-clinical-study
#5
Predrag Ostojic, Goran Radunovic, Milica Lazovic, Sanja Tomanovic-Vujadinovic
OBJECTIVE: to estimate whether combination of ibuprofen and paracetamol is more effective than ibuprofen in monotherapy, in the treatment of acute low back pain. METHODS: 80 adult patients with acute low back pain were randomized into two subgroups. In the first subgroup, 40 patients were treated with ibuprofen 400mg three times a day (TID), whilst patients in the second subgroup (n=40) were treated with a fixed-dose combination tablet of ibuprofen 200mg plus paracetamol 325mg TID, for three consecutive days...
December 13, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27965488/rebamipide-to-manage-stomatopyrosis-in-oral-submucous-fibrosis
#6
Joanna Baptist, Shrijana Shakya, Ravikiran Ongole
INTRODUCTION: Oral submucous fibrosis (OSF) causes progressive debilitating symptoms, such as oral burning sensation (stomatopyrosis) and limited mouth opening. The standard of care (SOC) protocol includes habit cessation, intralesional steroid and hyaluronidase injections, and mouth opening exercises. The objective of the study was to evaluate efficacy of rebamipide in alleviating burning sensation of the oral mucosa in OSF in comparison with SOC intralesional steroid injections. MATERIALS AND METHODS: Twenty OSF patients were divided into two groups [rebamipide (100 mg TID for 21 days) and betamethasone (4 mg/mL biweekly for 4 weeks)] of 10 each by random sampling...
December 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27943311/fv-100-versus-valacyclovir-for-the-prevention-of-post-herpetic-neuralgia-and-the-treatment-of-acute-herpes-zoster-associated-pain-a-randomized-controlled-trial
#7
Stephen K Tyring, Patricia Lee, Gordon T Hill, Joel C Silverfield, Angela Yen Moore, Theresa Matkovits, John Sullivan-Bolyai
This prospective, parallel-group, randomized, double-blind, multicenter study compared the efficacy and safety of FV-100 with valacyclovir for reducing pain associated with acute herpes zoster (HZ). Patients, ≥50 years of age, diagnosed with HZ within 72 h of lesion appearance who had HZ-associated pain, were randomized 1:1:1 to a 7-day course of either FV-100 200 mg QD (n = 117), FV-100 400 mg QD (n = 116), or valacyclovir 1000 mg TID (n =117). Efficacy was evaluated on the basis of the burden of illness (BOI; Zoster Brief Pain Inventory scores); incidence and duration of clinically significant pain (CSP); pain scores; incidence and severity of post-herpetic neuralgia (PHN); and times to full lesion crusting and to lesion healing...
December 12, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27942560/dataset-for-analysing-the-relationships-among-economic-growth-fossil-fuel-and-non-fossil-fuel-consumption
#8
John Asafu-Adjaye, Dominic Byrne, Maximiliano Alvarez
The data presented in this article are related to the research article entitled 'Economic Growth, Fossil Fuel and Non-Fossil Consumption: A Pooled Mean Group Analysis using Proxies for Capital' (J. Asafu-Adjaye, D. Byrne, M. Alvarez, 2016) [1]. This article describes data modified from three publicly available data sources: the World Bank׳s World Development Indicators (http://databank.worldbank.org/data/reports.aspx?source=world-development-indicators), the U.S. Energy Information Administration׳s International Energy Statistics (http://www...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/27933184/coxsackie-adenovirus-receptor-expression-is-enhanced-in-pancreas-from-patients-with-type-1-diabetes
#9
M Hodik, M Anagandula, J Fuxe, L Krogvold, K Dahl-Jørgensen, H Hyöty, L Sarmiento, G Frisk
OBJECTIVES: One of the theories connecting enterovirus (EV) infection of human islets with type 1 diabetes (T1D) is the development of a fertile field in the islets. This implies induction of appropriate proteins for the viral replication such as the coxsackie-adenovirus receptor (CAR). The aim of this study was to investigate to what extent CAR is expressed in human islets of Langerhans, and what conditions that would change the expression. DESIGN: Immunohistochemistry for CAR was performed on paraffin-embedded pancreatic tissue from patients with T1D (n=9 recent onset T1D, n=4 long-standing T1D), islet autoantibody-positive individuals (n=14) and non-diabetic controls (n=24) individuals...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27931551/metabolic-manipulation-in-dilated-cardiomyopathy-assessing-the-role-of-trimetazidine
#10
Suman Jatain, Aditya Kapoor, Archana Sinha, Roopali Khanna, Sudeep Kumar, Naveen Garg, Satyendra Tewari, Pravin Goel
OBJECTIVES: To study the role of metabolic modulator (trimetazidine: TMZ) in dilated cardiomyopathy (DCM). Optimizing altered substrate metabolism in heart failure (HF) with metabolic modulators allows more efficacious energy production from glucose than from free fatty acids. METHODS: 100 patients of DCM (47.7 years, NYHA class 2.17, LVEF 27.3%) were randomized to TMZ (20mg tid, n=50) vs conventional therapy (n=50). Functional status, BNP and various echocardiographic parameters were assessed at 3-6 months...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27905112/evolution-of-defects-in-titanium-grade-2-under-ti-2-ion-irradiation
#11
REVIEW
E Jouanny, S Doriot, J Malaplate, M Dehmas, L Allais, M LE Thuaut, T Millot
The complexity and diversity of microstructure involved in titanium alloys make it rather difficult to quantitatively describe defect evolution due to irradiation. This paper focuses on defect evolutions of commercially pure titanium grade 2 under Ti(2+) ion irradiation considering the effect of dose (0.6 and 3 dpa), temperature (300°C and 430°C) and flux (15:1 ratio). An irradiation damage profile was predicted using SRIM software to obtain a homogeneous damage on at least 500 nm depth for TEM observations and simulated using JANNUS-Saclay facility...
December 1, 2016: Journal of Microscopy
https://www.readbyqxmd.com/read/27890471/rationale-and-study-design-of-motion-a-phase-4-prospective-single-arm-open-label-study-to-measure-outcomes-in-patients-with-pulmonary-arterial-hypertension-not-on-active-treatment
#12
Stephen C Mathai, Omar Minai, Sean D Sullivan, Debra Lerner, Deborah Levine
In clinical trials of treatments for pulmonary arterial hypertension (PAH), objective measures, such as 6-min walking distance (6MWD) are limited in their ability to characterize the impact of PAH therapy from a patient's perspective. Few clinical studies have evaluated the primary effects of pharmacologic treatment on patient-reported outcomes, such as symptoms, health-related quality of life (HRQoL), and productivity. MOTION (NCT02191137) is a prospective, multicenter, single-arm, open-label, phase 4 trial designed to assess whether riociguat monotherapy will improve patient-reported outcomes in patients with PAH in the United States who are not currently on treatment...
November 2, 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27887774/rationale-and-study-design-of-respite-an-open-label-phase-3b-study-of-riociguat-in-patients-with-pulmonary-arterial-hypertension-who-demonstrate-an-insufficient-response-to-treatment-with-phosphodiesterase-5-inhibitors
#13
Marius M Hoeper, James R Klinger, Raymond L Benza, Gerald Simonneau, David Langleben, Robert Naeije, Paul A Corris
Patients with pulmonary arterial hypertension (PAH) who do not have an adequate response to therapy with phosphodiesterase-5 inhibitors (PDE-5i) may have insufficient synthesis of cyclic guanosine monophosphate (cGMP). These patients may respond to a direct soluble guanylate cyclase (sGC) stimulator such as riociguat. RESPITE (NCT02007629) was an open-label, multicenter, uncontrolled, single-arm phase 3b study of riociguat in patients with PAH who demonstrated an insufficient response to treatment with PDE-5i...
November 5, 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27885591/the-impact-of-non-steroidal-anti-inflammatory-agents-after-phacoemulsification-on-quality-of-life-a-randomized-study
#14
Irini P Chatziralli, Theodoros N Sergentanis, Efstratios A Parikakis, Leonidas E Papazisis, Panagiotis Mitropoulos, Marilita M Moschos
INTRODUCTION: The purpose of our study was to investigate the impact of ketorolac addition to the well-established combination of antibiotic-steroid agent in terms of vision-related quality of life. METHODS: Patients were randomized to: (1) fixed combination of tobramycin 0.3%-dexamethasone 0.1%, one drop qid (n = 68) and (2) fixed combination of tobramycin 0.3%-dexamethasone 0.1%, one drop qid, plus ketorolac tromethamine 0.5%, one drop tid (n = 70). All patients completed the VFQ-25 questionnaire to assess their functional vision before cataract surgery and postoperatively on days 7, 28 and 42...
November 24, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27877093/adolescent-clinical-development-of-ezogabine-retigabine-as-adjunctive-therapy-for-partial-onset-seizures-pharmacokinetics-and-tolerability
#15
Debra J Tompson, Mauro Buraglio, Susan M Andrews, James W Wheless
OBJECTIVES: To explore the pharmacokinetic (PK) profile and safety of ezogabine (EZG)/retigabine (RTG) as adjunctive therapy for uncontrolled partial-onset seizures (POS) in adolescents. METHODS: In this multiple-dose study (NCT01494584), adolescents with POS received EZG/RTG immediate-release tablets three times daily (TID) as adjunctive therapy to 1 to 3 concurrent antiepileptic drugs. The study comprised a screening phase, and a 5- to 8-week treatment phase starting with 100 mg TID up-titrated once weekly by ≤50 mg TID to a maximum dosage of 300 mg TID...
September 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/27856224/tid-standalone-software-for-mining-putative-drug-targets-from-bacterial-proteome
#16
Reena Gupta, Dibyabhaba Pradhan, Arun Kumar Jain, Chandra Shekhar Rai
TiD is a standalone application, which relies on basic assumption that a protein must be essential for pathogens survival and non-homologous with host to qualify as putative target. With an input bacterial proteome, TiD removes paralogous proteins, picks essential ones, and excludes proteins homologous with host organisms. The targets illustrate non-homology with at least 40 out of 84 gut microbes, considered safe for human. TiD classifies proposed targets as known, novel and virulent. Users can perform pathway analysis, choke point analysis, interactome analysis, subcellular localization and functional annotations through web servers cross-referenced with the application...
January 2017: Genomics
https://www.readbyqxmd.com/read/27855434/trends-in-the-outpatient-utilization-of-antipsychotic-drugs-in-the-city-of-zagreb-in-the-ten-year-period-as-a-tool-to-assess-drug-prescribing-rationality
#17
Marina Polić-Vižintin, Ingrid Tripković, Danijela Štimac, Zvonimir Šostar, Mirjana Orban
BACKGROUND: The aim was to determine distribution and trends in the outpatient utilization of antipsychotics to evaluate the rationality of antipsychotic drug prescribing during the ten year period. SUBJECTS AND METHODS: The epidemiological method of descriptive and analytical observation was used. Data on drug utilization from Zagreb Municipal Pharmacy were used to calculate the number of defined daily doses (DDD) and DDD per 1000 inhabitants per day (DDD/TID) using the World Health Organization Anatomical-Therapeutic-Chemical methodology...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27853981/intensification-of-idegasp-twice-daily-adding-insulin-aspart-vs-switching-to-basal-bolus-exploratory-randomized-trial-in-type-2-diabetes
#18
Wan Mohamaed Wan Bebakar, Louis Chaykin, Malene Lundgren Hersløv, Søren Rasmussen
INTRODUCTION: In a preceding trial comparing two different titration schemes, insulin degludec/insulin aspart (IDegAsp) showed good efficacy for achieving HbA1c <7% when administered twice daily (BID) in patients with uncontrolled type 2 diabetes (T2D). However, poor glycemic control persisted in a minority of patients. The current exploratory trial investigated the efficacy and safety of intensifying IDegAsp BID treatment in these patients by either adding a once-daily (OD) bolus injection of insulin aspart (IAsp) or by switching to a basal-bolus regimen of insulin degludec (IDeg) plus IAsp taken three times a day (TID)...
November 16, 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/27834793/b-cell-receptor-affinity-for-insulin-dictates-autoantigen-acquisition-and-b-cell-functionality-in-autoimmune-diabetes
#19
Thomas A Packard, Mia J Smith, Francis J Conrad, Sara A Johnson, Andrew Getahun, Robin S Lindsay, Rochelle M Hinman, Rachel S Friedman, James W Thomas, John C Cambier
B cells have been strongly implicated in the development of human type 1 diabetes and are required for disease in the NOD mouse model. These functions are dependent on B cell antigen receptor (BCR) specificity and expression of MHC, implicating linked autoantigen recognition and presentation to effector T cells. BCR-antigen affinity requirements for participation in disease are unclear. We hypothesized that BCR affinity for the autoantigen insulin differentially affects lymphocyte functionality, including tolerance modality and the ability to acquire and become activated in the diabetogenic environment...
November 8, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27828189/method-to-improve-the-linearity-of-the-silicon-mach-zehnder-optical-modulator-by-doping-control
#20
Jianfeng Ding, Sizhu Shao, Lei Zhang, Xin Fu, Lin Yang
We optimize the linearity performance of silicon carrier-depletion Mach-Zehnder optical modulator through controlling the doping concentration. The optical field distribution in the waveguide is a Gaussian-like distribution. As the doping concentration increases, the dynamic depletion width of the PN junction under the same modulation signal will decrease, and the integration width of the overlap between the Gaussian-like optical field distribution and the depletion region will become smaller. Therefore the modulated signal has less nonlinear components...
October 17, 2016: Optics Express
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