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https://www.readbyqxmd.com/read/29351287/a-novel-association-rule-mining-approach-using-tid-intermediate-itemset
#1
Iyad Aqra, Tutut Herawan, Norjihan Abdul Ghani, Adnan Akhunzada, Akhtar Ali, Ramdan Bin Razali, Manzoor Ilahi, Kim-Kwang Raymond Choo
Designing an efficient association rule mining (ARM) algorithm for multilevel knowledge-based transactional databases that is appropriate for real-world deployments is of paramount concern. However, dynamic decision making that needs to modify the threshold either to minimize or maximize the output knowledge certainly necessitates the extant state-of-the-art algorithms to rescan the entire database. Subsequently, the process incurs heavy computation cost and is not feasible for real-time applications. The paper addresses efficiently the problem of threshold dynamic updation for a given purpose...
2018: PloS One
https://www.readbyqxmd.com/read/29344922/impact-of-renin-angiotensin-aldosterone-system-polymorphisms-on-myocardial-perfusion-correlations-with-myocardial-single-photon-emission-computed-tomography-derived-parameters
#2
George Angelidis, Maria Samara, Maria Papathanassiou, Maria Satra, Varvara Valotassiou, Ioannis Tsougos, Dimitrios Psimadas, Chara Tzavara, Sotiria Alexiou, John Koutsikos, Nikolaos Demakopoulos, Gregory Giamouzis, Filippos Triposkiadis, John Skoularigis, Panagoula Kollia, Panagiotis Georgoulias
BACKGROUND: Renin-angiotensin-aldosterone system (RAAS) has an important role in atherosclerosis. We investigated the effects of six RAAS gene polymorphisms on myocardial perfusion. METHODS AND RESULTS: We examined 810 patients with known or suspected coronary artery disease (CAD) using stress-rest myocardial single-photon emission computed tomography. Summed stress score (SSS), summed rest score (SRS), summed difference score (SDS), transient ischemic dilation (TID), and lung/heart ratio (LHR) were recorded...
January 17, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29344919/the-impact-of-patient-to-detector-distance-on-lv-volumes-and-tid-index-on-spect-myocardial-perfusion-imaging-emphasis-on-consistent-patient-detector-positioning-in-stress-and-rest-phases
#3
Mohsen Qutbi, Mehdi Soltanshahi
No abstract text is available yet for this article.
January 17, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29330194/telotristat-ethyl-in-carcinoid-syndrome-safety-and-efficacy-in-the-telecast-phase-3-trial
#4
Marianne E Pavel, David J Gross, Marta Benavent, Petros Perros, Raj Srirajaskanthan, Richard R P Warner, Matthew H Kulke, Lowell Anthony, Pamela Kunz, Dieter Hörsch, Martin O Weickert, Pablo Lapuerta, Wenjun Jiang, Kenneth Kassler-Taub, Suman Wason, Rosanna Fleming, Douglas Fleming, Rocio García-Carbonero
Telotristat ethyl, a tryptophan hydroxylase inhibitor, was efficacious and well tolerated in the Phase 3 TELESTAR study in patients with carcinoid syndrome (CS) experiencing ≥4 bowel movements per day (BMs/day) while on somatostatin analogs (SSAs). TELECAST, a Phase 3 companion study, assessed safety and efficacy of telotristat ethyl in patients with CS (diarrhea, flushing, abdominal pain, nausea, or elevated urinary 5-hydroxyindoleacetic acid [u5-HIAA]) with <4 BMs/day on SSAs (or ≥1 symptom or ≥4 BMs/day if not on SSAs) during a 12-week double-blind treatment period followed by a 36-week open-label extension (OLE)...
January 12, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29315699/topical-administration-of-regorafenib-eye-drops-phase-i-dose-escalation-study-in-healthy-volunteers
#5
Torsten Zimmermann, Joachim Höchel, Michael Becka, Michael K Boettger, Beate Rohde, Barbara Schug, Kathleen S Kunert, Frank Donath
AIM: Regorafenib is a multi-kinase inhibitor under investigation for use in neovascular age-related macular degeneration. In this Phase I study, regorafenib eye drops were administered to healthy volunteers to provide information on safety, tolerability and systemic exposure. METHODS: This was a single-centre, randomized, double-masked, parallel-group, dose-escalation, placebo-controlled study. Subjects received regorafenib eye drops (30 mg ml-1 , 25 μL) as a 0...
January 9, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29282189/cutaneous-mucormycosis-a-fatal-complication-of-immunosuppressant-therapy-for-pemphigus-vulgaris
#6
Kanika Sahni, Dipankar De, Sunil Dogra, Amrinderjit Kanwar, Uma Nahar Saikia
A 62-year-old man with no comorbidities presented to the outpatient department of our Institute with a history of extensive vesiculobullous and erosive skin lesions and oral erosions for 2 months and fever for 1 week. A diagnosis of pemphigus vulgaris was made based on histopathology and direct immunofluorescence of a skin biopsy specimen, and the patient was started on oral prednisolone 40 mg per day along with intravenous antibiotics (amoxicillin-clavulanic acid, gentamicin, and metronidazole) empirically, pending blood and skin swab culture and sensitivity reports...
2017: Skinmed
https://www.readbyqxmd.com/read/29282032/riociguat-in-patients-with-chronic-thromboembolic-pulmonary-hypertension-results-from-an-early-access-study
#7
Vallerie V McLaughlin, Pavel Jansa, Jens E Nielsen-Kudsk, Michael Halank, Gérald Simonneau, Ekkehard Grünig, Silvia Ulrich, Stephan Rosenkranz, Miguel A Gómez Sánchez, Tomás Pulido, Joanna Pepke-Zaba, Joan Albert Barberá, Marius M Hoeper, Jean-Luc Vachiéry, Irene Lang, Francine Carvalho, Christian Meier, Katharina Mueller, Sylvia Nikkho, Andrea M D'Armini
BACKGROUND: Following positive results from the Phase III CHEST-1 study in patients with inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH), the Phase IIIb CTEPH early access study (EAS) was designed to assess the safety and tolerability of riociguat in real-world clinical practice, as well as to provide patients with early access to riociguat before launch. Riociguat is approved for the treatment of inoperable and persistent/recurrent CTEPH. METHODS: We performed an open-label, uncontrolled, single-arm, early access study in which 300 adult patients with inoperable or persistent/recurrent CTEPH received riociguat adjusted from 1 mg three times daily (tid) to a maximum of 2...
December 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29239664/efficacy-and-safety-of-twice-daily-sustained-release-paracetamol-formulation-for-osteoarthritis-pain-of-the-knee-or-hip-a-randomized-double-blind-placebo-controlled-twelve-week-study
#8
Kenneth Reed, Agron Collaku, Sebastian Moreira
OBJECTIVE: Evaluate efficacy and safety of an investigational, twice-daily sustained-release (SR) paracetamol formulation in subjects with knee or hip osteoarthritis (OA). METHODS: In this multicenter, double-blind, parallel study (NCT02311881), subjects with hip or knee OA were randomly assigned to SR paracetamol 2x1000 mg BID, extended-release (ER) paracetamol 2x665 mg TID, or placebo for 12 weeks. Primary endpoint was mean change from baseline through 12 weeks in WOMAC Osteoarthritis Index pain...
December 14, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29227664/a-deep-blue-high-efficiency-tta-oled-using-para-and-meta-conjugated-cyano-triphenylbenzene-and-carbazole-derivatives-as-emitter-and-host
#9
Nadzeya A Kukhta, Tomas Matulaitis, Dmytro Volyniuk, Khrystyna Ivaniuk, Pavlo Turyk, Pavlo Stakhira, Juozas Vidas Grazulevicius, Andrew P Monkman
Elaboration of the appropriate host materials proved to be not less important for the fabrication of a highly efficient OLED, than the design of emitters. In present work we show how by simple variation of molecular structure both blue emitters exhibiting delayed fluorescence and ambipolar high triplet energy hosts can be obtained. The compounds with para-junction revealed higher thermal stability (TID up to 480 oC), lower ionization potentials (5.51-5.60 eV), exclusively hole transport and higher photoluminescence quantum efficiencies (0...
December 11, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29216074/diffraction-mechanism-of-a-light-diffusing-film-with-an-alternate-polymer-layer-structure
#10
Yoshifumi Sekiguchi, Takahiro Ishinabe, Souichirou Seo, Yosei Shibata, Hideo Fujikake
A diffraction mechanism, and an optical model to reflect that mechanism, for a light-diffusing film with an alternate-polymer-layer structure was proposed and validated. According to this model, the film forms an angular distribution of light intensity that is almost constant in a certain scattering-angle (cutoff angle) range and drastically decreases outside that range; that is, the profile is similar to a trapezoid. Although the trapezoid intensity distribution (TID) is a fundamental distribution of the film, the mechanism to form the TID has not previously been clarified...
December 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29199694/retrospective-analysis-of-icotinib-neoadjuvant-therapy-of-63-lung-cancer-patients
#11
T Wang, Y Liu, B Zhou, S Hao, Z Wang, N Liang, J Liu, S Wang
OBJECTIVE: This study aims to explore the feasibility of icotinib neoadjuvant therapy for nonsmall cell lung cancer (NSCLC). MATERIALS AND METHODS: This was a retrospective analysis of the clinical data for 63 NSCLC patients (61 cases of adenocarcinoma and two cases of squamous cell carcinoma) receiving surgical resection of lung lesions after oral intake of icotinib from December 2011 to November 2013 in the PLA General Hospital. Preoperative oral intake of the patients was icotinib 125 mg tid, drug side effects were evaluated according to the American National Cancer Institute Common Toxicity Criteria Version 4...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29196322/a-new-high-efficacy-non-invasive-transcranial-electric-stimulation-tuned-to-local-neurodynamics
#12
Carlo Cottone, Andrea Cancelli, Patrizio Pasqualetti, Camillo Porcaro, Carlo Salustri, Franca Tecchio
In this paper, we pose the following working hypothesis: in humans, transcranial electric stimulation (tES) with a time course that mimics the endogenous activity of its target is capable of altering the target's excitability. In our case, the target was the primary motor cortex (M1). We identified the endogenous neurodynamics of hand M1's subgroups of pyramidal neuronal pools in each of our subjects by applying Functional Source Separation (FSS) to their electroencephalographic (EEG) recordings. We then tested whether the cortico-spinal excitability of the hand representation under the above described stimulation, which we named transcranial Individual neuroDynamics Stimulation (tIDS), was higher than in the absence of stimulation (baseline)...
December 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29189728/proton-radiation-effects-on-dark-signal-distribution-of-ppd-cmos-image-sensors-both-tid-and-ddd-effects
#13
Yuanyuan Xue, Zujun Wang, Wei Chen, Minbo Liu, Baoping He, Zhibin Yao, Jiangkun Sheng, Wuying Ma, Guantao Dong, Junshan Jin
Four-transistor (T) pinned photodiode (PPD) CMOS image sensors (CISs) with four-megapixel resolution using 11µm pitch high dynamic range pixel were radiated with 3 MeV and 10MeV protons. The dark signal was measured pre- and post-radiation, with the dark signal post irradiation showing a remarkable increase. A theoretical method of dark signal distribution pre- and post-radiation is used to analyze the degradation mechanisms of the dark signal distribution. The theoretical results are in good agreement with experimental results...
November 30, 2017: Sensors
https://www.readbyqxmd.com/read/29184260/topical-effects-of-artemisia-absinthium-ointment-and-liniment-in-comparison-with-piroxicam-gel-in-patients-with-knee-joint-osteoarthritis-a-randomized-double-blind-controlled-trial
#14
Zahra Basiri, Fatemeh Zeraati, Farzaneh Esna-Ashari, Farshid Mohammadi, Keyvan Razzaghi, Malihe Araghchian, Shirin Moradkhani
Background: Pain alleviation and improvement of functional status are the main objectives in the treatment of osteoarthritis. Artemisia absinthium (AA) was used traditionally in reducing pain and inflammation. The aim of the present study was to compare the effects of topical formulations of AA and piroxicam gel (PG) among patients with knee osteoarthritis. Methods: In total, 90 outpatients aged 30-70 years with the diagnosis of primary osteoarthritis in at least one knee were enrolled in a randomized double-blind clinical trial...
November 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29176924/novel-phonotactic-learning-tracking-syllable-position-and-co-occurrence-constraints
#15
Amélie Bernard
Are syllable-level and co-occurrence representations simultaneously available when one learns novel phonotactics? After training on word-medial consonant restrictions (e.g., word-medial onsets P/Z, codas D/F, and cross-syllable consonant clusters FP/DZ in items like baF.Pev, tiD.Zek), adults falsely recognized novel items containing restricted consonants with the same co-occurrences (e.g., FP) more often than those with different co-occurrences (e.g., FZ) when syllable-position information was kept constant (e...
October 2017: Journal of Memory and Language
https://www.readbyqxmd.com/read/29158143/urinary-concentration-and-antimicrobial-activity-of-tobramycin-in-healthy-volunteers-receiving-a-single-oral-dose-of-a-novel-formulation-for-improved-absorption
#16
Maria Loose, Kurt G Naber, Paul Shields, Harald Reinhart, Florian M E Wagenlehner
BACKGROUND: Oral antibiotics for the treatment of UTI are scarce. In this ex vivo phase 1 annex study, clinical safety, urinary concentrations and bactericidal activity of a new formulation for improved oral absorption of tobramycin (Tobrate(TM)) were evaluated. METHODS: The minimal inhibitory and bactericidal concentrations (MIC/MBC) of five test strains, one reference strain and four clinical uropathogenic strains, were determined in cation-adjusted Mueller-Hinton Broth (CAMHB) and in pooled antimicrobial agent-free urine of the subjects at different pH (5...
November 17, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29152762/optimizing-lonafarnib-treatment-for-the-management-of-chronic-delta-hepatitis-the-lowr-hdv-1-study
#17
Cihan Yurdaydin, Onur Keskin, Çağdaş Kalkan, Fatih Karakaya, Aysun Çalişkan, Ersin Karatayli, Senem Karatayli, A Mithat Bozdayi, Christopher Koh, Theo Heller, Ramazan Idilman, Jeffrey S Glenn
BACKGROUND AND RATIONALE: In a proof-of-concept (POC) study, the oral prenylation inhibitor lonafarnib (LNF) decreased HDV RNA during 4 weeks of treatment. Here we explored optimal LNF regimens. METHODS: 15 patients (5 groups; 3 per group) completed dosing as follows: 1) LNF 200 mg BID (12 weeks); 2) LNF 300 mg BID (12 weeks); 3) LNF 100 mg TID (5 weeks); 4) LNF 100 mg BID + pegylated interferon alfa (PEG-IFNα) 180 mcg QW (8 weeks); and 5) LNF 100 mg BID + ritonavir (RTV) 100 mg QD (8 weeks)...
November 20, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29129018/a-32-week-randomized-comparison-of-stepwise-insulin-intensification-of-biphasic-insulin-aspart-biasp%C3%A2-30-versus-basal-bolus-therapy-in-insulin-na%C3%A3-ve-patients-with-type-2-diabetes
#18
Sultan Linjawi, Byung-Wan Lee, Ömür Tabak, Susanna Lövdahl, Shanti Werther, Salahedeen Abusnana
INTRODUCTION: This 32-week, open-label, randomized, parallel-group, multinational trial aimed to compare the efficacy and safety of stepwise insulin intensification of biphasic insulin aspart 30 (BIAsp 30) relative to stepwise intensification of a basal-bolus regimen in insulin-naïve adults with type 2 diabetes (T2D) who continued pretrial treatment with metformin and sulfonylurea. METHODS: Adults with T2D were randomized into one of two treatment arms for 32 weeks: (1) BIAsp 30 once daily (OD), with the possibility of stepwise treatment intensification up to BIAsp 30 three times daily (TID); (2) insulin glargine OD, with the possibility of stepwise treatment intensification with insulin aspart up to TID...
November 11, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29128692/coast-cisplatin-ototoxicity-attenuated-by-aspirin-trial-a-phase-ii-double-blind-randomised-controlled-trial-to-establish-if-aspirin-reduces-cisplatin-induced-hearing-loss
#19
Simon J Crabb, Karen Martin, Julia Abab, Ian Ratcliffe, Roger Thornton, Ben Lineton, Mary Ellis, Ronald Moody, Louise Stanton, Angeliki Galanopoulou, Tom Maishman, Thomas Geldart, Mike Bayne, Joe Davies, Carolynn Lamb, Sanjay Popat, Johnathan K Joffe, Chris Nutting, John Chester, Andrew Hartley, Gareth Thomas, Christian Ottensmeier, Robert Huddart, Emma King
BACKGROUND: Cisplatin is one of the most ototoxic chemotherapy drugs, resulting in a permanent and irreversible hearing loss in up to 50% of patients. Cisplatin and gentamicin are thought to damage hearing through a common mechanism, involving reactive oxygen species in the inner ear. Aspirin has been shown to minimise gentamicin-induced ototoxicity. We, therefore, tested the hypothesis that aspirin could also reduce ototoxicity from cisplatin-based chemotherapy. METHODS: A total of 94 patients receiving cisplatin-based chemotherapy for multiple cancer types were recruited into a phase II, double-blind, placebo-controlled trial and randomised in a ratio of 1:1 to receive aspirin 975 mg tid and omeprazole 20 mg od, or matched placebos from the day before, to 2 days after, their cisplatin dose(s), for each treatment cycle...
November 9, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29110425/therapeutic-response-to-domperidone-in-gastroparesis-a%C3%A2-prospective-study-using-the-gcsi-daily-diary
#20
J Heckert, H P Parkman
Common symptoms of gastroparesis include nausea, vomiting, early satiety, postprandial fullness, and upper abdominal pain. Domperidone is used for treatment of gastroparesis. Daily symptom scoring may help document efficacy. AIM: To determine the effectiveness of domperidone for gastroparesis symptoms using the gastroparesis cardinal symptom index-daily diary (GCSI-DD) and to determine which symptoms improve and when with domperidone treatment. METHODS: Symptomatic patients with diabetic or idiopathic gastroparesis were enrolled...
November 7, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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