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https://www.readbyqxmd.com/read/29790057/are-youth-sport-talent-identification-and-development-systems-necessary-and-healthy
#1
Fieke Rongen, Jim McKenna, Stephen Cobley, Kevin Till
Talent identification and development systems (TIDS) are commonly used in professional sport to convert youth athletes into sporting stars of the future. Acknowledging that only a few athletes can "make it," the necessity and healthiness of TIDS have recently been questioned based on their increased professionalism, high training, and competition volumes, but limited effectiveness. In this short communication, we suggest that the key issues associated with TIDS are not due to their overall concept, but with how they are designed and implemented...
May 22, 2018: Sports Medicine—Open
https://www.readbyqxmd.com/read/29782387/income-relates-to-adherence-in-youth-with-type-1-diabetes-through-parenting-constructs
#2
Dexter M Thomas, Leah M Lipsky, Aiyi Liu, Tonja R Nansel
OBJECTIVE: Informed by the family stress and family investment models, this study investigated whether income is indirectly related to adherence and glycemic control through parenting constructs among youth with type 1 diabetes (TID). METHODS: Youth and their families (n = 390) from 4 geographically dispersed pediatric endocrinology clinics in the United States were participants in a multisite clinical trial from 2006 to 2009 examining the efficacy of a clinic-integrated behavioral intervention targeting family disease management for youth with TID...
May 17, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29767775/tobacco-industry-denormalisation-beliefs-in-hong-kong-adolescents
#3
Jianjiu Chen, Sai Yin Ho, Lok Tung Leung, Man Ping Wang, Tai Hing Lam
Introduction: Tobacco industry denormalisation (TID) seeks to expose the industry's misconducts. Research on TID beliefs, meaning negative attitudes towards the tobacco industry (TI), may inform TID programmes, but was limited to western populations. We investigated TID beliefs and their association with smoking and sociodemographic characteristics in Hong Kong adolescents. Methods: In a school-based cross-sectional survey of 14214 students (mean age 15.0 years, 51...
May 15, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29738185/-huangjing-zanyu-capsule-enhances-sperm-mitochondrial-membrane-potential-in-asthenozoospermia-patients
#4
Jian-Lin Hu, Jian Sun, Wei Chen, Yi-Xia Yang, Yuan Xu, Yu Wu, Xiao-Wen Sun, Zheng Li
Objective: To observe the effect of Huangjing Zanyu Capsule (HZC) on sperm mitochondrial membrane potential (MMP) in asthenozoospermia patients. METHODS: We assigned 70 asthenozoospermia patients to a treatment group (n = 39) and a control group (n = 31), the former treated with oral HZC at the dose of 4 capsules tid for 3 months while the latter left untreated. We obtained semen parameters from the patients and detected their sperm mitochondrial membrane potentials (MMP) by JC-1 staining and flow cytometry before and after medication, followed by comparison between the two groups...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29738183/-efficacy-of-lamiophlomis-rotata-capsule-in-the-treatment-of-type-%C3%A2-b-prostatitis
#5
Zhi-Feng Wei, Kai Zhou, Jie Dong, Dian Fu, Xiao-Feng Xu, Ping Li, Wen Cheng, Zheng-Yu Zhang
Objective: To study the therapeutic effect of Lamiophlomis Rotata Capsule (LRC) in the treatment of type ⅢB prostatitis. METHODS: We randomly divided 225 patients with type ⅢB prostatitis into an experimental group (n =125) and a control group (n =120), the former treated orally with LRC at 3 capsules tid while the latter with tamsulosin hydrochloride sustained-release capsules at 0.2 mg qd, both for 4 weeks. We compared the therapeutic effects between the two groups of patients based on the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) obtained before, immediately after and at 4 weeks after medication...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29736244/propranolol-pharmacokinetics-in-infants-treated-for-infantile-hemangiomas-requiring-systemic-therapy-modeling-and-dosing-regimen-recommendations
#6
Laurence Del Frari, Christine Léauté-Labrèze, Laurent Guibaud, Sébastien Barbarot, Jean-Philippe Lacour, Christine Chaumont, Alain Delarue, Jean-Jacques Voisard, Valérie Brunner
Propranolol has become the first choice therapy for complicated Infantile Hemangiomas (IH). The pharmacokinetics of propranolol were evaluated after repeated oral administration of a new pediatric solution of propranolol at 3 mg kg-1  day-1 given twice daily (BID) in infants (77-243 days) with IH. A population model was built to describe the pharmacokinetics of propranolol in infants and to simulate different dosing regimens. One hundred and sixty-seven plasma concentrations from 22 infants were used in the population analysis...
June 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29733106/how-do-stimulant-treatments-for-adhd-work-evidence-for-mediation-by-improved-cognition
#7
Larry W Hawk, Whitney D Fosco, Craig R Colder, James G Waxmonsky, William E Pelham, Keri S Rosch
BACKGROUND: Stimulant medications such as methylphenidate (MPH) are the frontline treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). Despite their well-documented efficacy, the mechanisms by which stimulants improve clinical outcomes are not clear. The current study evaluated whether MPH effects on classroom behavior were mediated by improved cognitive functioning. METHODS: Children with ADHD (n = 82; 9-12 years old) participated in a week-long summer research camp, consisting of cognitive testing, classroom periods, and recreational activities...
May 7, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29727535/-clinical-treatment-of-erectile-dysfunction-in-type-2-diabeticpatients-in-the-high-altitude-area
#8
Fu-Dong Li, Bin Zhang, Yang-Min Wang
Objective: To investigate the safety and efficacy of pancreatic kininogenase combined with sildenafil in the treatment of erectile dysfunction(ED) in type 2 diabetes mellitus (DM) patients in the high-altitude area. METHODS: This study included 93 ED patients with type 2 DM, all residents of the Xining area 1500 meters above sea level. We randomly divided them into an experimental group (n = 48) and a control group (n = 45), the former treated with pancreatic kininogenase(120 u, tid) and sildenafil (25 mg, qd at bedtime), while the latter with sildenafil only (25 mg, qd at bedtime)...
October 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29724499/changes-in-weight-associated-with-telotristat-ethyl-in-the-treatment-of-carcinoid-syndrome
#9
Martin O Weickert, Gregory Kaltsas, Dieter Hörsch, Pablo Lapuerta, Marianne Pavel, Juan W Valle, Martyn E Caplin, Emily Bergsland, Pamela L Kunz, Lowell B Anthony, Enrique Grande, Kjell Öberg, Staffan Welin, Catherine Lombard-Bohas, John K Ramage, Ashwin Kittur, Qi M Yang, Matthew H Kulke
PURPOSE: In the placebo-controlled Phase III TELESTAR (Telotristat Etiprate for Somatostatin Analogue Not Adequately Controlled Carcinoid Syndrome) trial, the oral tryptophan hydroxylase inhibitor telotristat ethyl significantly reduced bowel movement (BM) frequency during a 12-week, double-blind treatment period in 135 patients with metastatic neuroendocrine tumors with carcinoid syndrome and ≥4 BMs per day. Patients (mean [SD] age, 63.5 [8.9] years; mean [SD] body mass index, 24.9 [4...
April 30, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29723200/longitudinal-motor-performance-development-in-early-adolescence-and-its-relationship-to-adult-success-an-8-year-prospective-study-of-highly-talented-soccer-players
#10
Daniel Leyhr, Augustin Kelava, Johannes Raabe, Oliver Höner
Several talent identification and development (TID) programs in soccer have implemented diagnostics to measure players' motor performance. Yet, there is a lack of research investigating the relationship between motor development in adolescence and future, adult performance. This longitudinal study analyzed the three-year development of highly talented young soccer players' speed abilities and technical skills and examined the relevance of this development to their adult success. The current research sample consisted of N = 1,134 players born between 1993 and 1995 who were selected for the German Soccer Association's TID program and participated in nationwide motor diagnostics (sprinting, agility, dribbling, ball control, shooting) four times between the Under 12 (U12) and Under 15 (U15) age class...
2018: PloS One
https://www.readbyqxmd.com/read/29715321/correction-a-novel-association-rule-mining-approach-using-tid-intermediate-itemset
#11
Iyad Aqra, Tutut Herawan, Norjihan Abdul Ghani, Adnan Akhunzada, Akhtar Ali, Ramdan Bin Razali, Manzoor Ilahi, Kim-Kwang Raymond Choo
[This corrects the article DOI: 10.1371/journal.pone.0179703.].
2018: PloS One
https://www.readbyqxmd.com/read/29713191/endoscopic-comparison-of-gastroduodenal-injury-with-over-the-counter-doses-of-new-fast-dissolving-ibuprofen-and-paracetamol-formulations-a-randomized-placebo-controlled-4-way-crossover-clinical-trial
#12
Frank L Lanza, Agron Collaku, Dongzhou J Liu
Background: While gastrointestinal (GI) effects of standard ibuprofen and N-acetyl-p-aminophenol (APAP) have been reported, upper GI injury following treatment with fast-dissolving (FD) formulations of these analgesics has not been investigated. We evaluated upper GI effects of over-the-counter doses of 2 FD ibuprofen products and 1 FD-APAP product. Methods: In a randomized, placebo-controlled, endoscopist-blinded, 4-way crossover study, 28 healthy subjects received FD ibuprofen 2×200 mg liquid capsules 3 times daily (TID), ibuprofen 2×200 mg tablets TID, FD-APAP 2×500 mg tablets 4 times daily (QID), and placebo 2×500 mg tablets QID for 7 days...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29708822/rifaximin-is-associated-with-modest-transient-decreases-in-multiple-taxa-in-the-gut-microbiota-of-patients-with-diarrhoea-predominant-irritable-bowel-syndrome
#13
Anthony A Fodor, Mark Pimentel, William D Chey, Anthony Lembo, Pamela L Golden, Robert J Israel, Ian M Carroll
Rifaximin, a non-systemic antibiotic, is efficacious for the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D). Given the emerging association between the gut microbiota and IBS, this study examined potential effects of rifaximin on the gastrointestinal microbial community in patients with IBS-D. TARGET 3 was a randomised, double-blind, placebo-controlled, phase 3 study. Patients with IBS-D initially received open-label rifaximin 550 mg 3 times daily (TID) for 2 weeks. Patients who responded to the initial treatment and then relapsed were randomised to receive 2 repeat courses of rifaximin 550 mg TID or placebo for 2 weeks, with each course separated by 10 weeks...
April 30, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29689485/the-effect-of-high-dose-dronabinol-oral-thc-maintenance-on-cannabis-self-administration
#14
Nicolas J Schlienz, Dustin C Lee, Maxine L Stitzer, Ryan Vandrey
BACKGROUND: There is a clear need for advancing the treatment of cannabis use disorders. Prior research has demonstrated that dronabinol (oral THC) can dose-dependently suppress cannabis withdrawal and reduce the acute effects of smoked cannabis. The present study was conducted to evaluate whether high-dose dronabinol could reduce cannabis self-administration among daily users. METHODS: Non-treatment seeking daily cannabis users (N = 13) completed a residential within-subjects crossover study and were administered placebo, low-dose dronabinol (120 mg/day; 40 mg tid), or high-dose dronabinol (180-240 mg/day; 60-80 mg tid) for 12 consecutive days (order counterbalanced)...
April 17, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29668604/sonographic-and-ct-imaging-features-of-intestinal-perforation-from-a-pill-and-packing-a-case-report
#15
Ze-Hui Gou, Yulan Peng, Kun Yang
RATIONALE: Sharp foreign bodies such as toothpicks or chicken bones can lead to intestinal perforation. Small intestinal perforation secondary to foreign body ingestion is usually manifested as an acute abdomen without a history of trauma. Here we describe the diagnosis and treatment of a case of small bowel perforation caused by an ingested pill and its outer packing. PATIENT CONCERNS: An 84 years old male patient complained of right lower abdominal pain for 4 days and the pain was becoming progressively worse...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29645278/an-evaluation-of-the-pharmacodynamics-safety-and-tolerability-of-the-potassium-binder-rdx7675
#16
Bertram Pitt, Vanessa Zann, Chris Roe, Jeffrey W Jacobs, James P Davidson, Christine Dowd, Padmapriya Kumaraswamy, Fangling Lin, Paul Korner, Robert C Blanks, David P Rosenbaum
Hyperkalemia is common in patients with heart failure or chronic kidney disease, particularly those taking renin-angiotensin-aldosterone system inhibitors, and can cause arrhythmias and sudden cardiac death. The most widely used treatment, sodium polystyrene sulfonate (SPS), limits gastrointestinal potassium absorption, but has poor palatability. RDX7675 (RDX227675) is the calcium salt of a reengineered polystyrene sulfonate-based resin with improved palatability over SPS. The pharmacodynamic effects and safety of RDX7675 were assessed in a phase 1, single-center, randomized, active-controlled study...
April 12, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29642532/ursodeoxycholate-restores-biliary-excretion-of-methotrexate-in-rats-with-ethinyl-estradiol-induced-cholestasis-by-restoring-canalicular-mrp2-expression
#17
Min Ju Kim, Yun Ju Kang, Mihwa Kwon, Young A Choi, Min-Koo Choi, Hye-Young Chi, Hye Hyun Yoo, Chang-Koo Shim, Im-Sook Song
The in vivo relevance of ursodeoxycholate (UDCA) treatment (100 mg/kg/day, per oral tid for 5 days before cholestasis induction followed by the same dosing for 5 days) on hepatic function was investigated in rats with 17α-ethinylestradiol (EE, 10 mg/kg, subcutaneous for 5 days)-induced experimental cholestasis. The bile flow rate and the expression level of hepatic multidrug resistance-associated protein 2 (Mrp 2) that were decreased in cholestasis were restored after UDCA treatment. Consistent with this, the biliary excretion clearance (CLexc,bile ) of a representative Mrp2 substrate-methotrexate (MTX)-was decreased in cholestatic rats but was restored after UDCA treatment...
April 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29624493/efficacy-and-safety-of-0-6-pazufloxacin-ophthalmic-solution-versus-moxifloxacin-0-5-and-gatifloxacin-0-5-in-subjects-with-bacterial-conjunctivitis-a-randomized-clinical-trial
#18
Leopoldo Baiza-Durán, Oscar Olvera-Montaño, Arieh R Mercado-Sesma, Aldo A Oregon-Miranda, Alfredo Lizárraga-Corona, Juan C Ochoa-Tabares, Ana L Pérez-Balbuena, Irene M Montoya-Sánchez, Laura R Saucedo-Rodríguez, Alfredo Mora-González, Pedro A Gómez-Bastar, Miguel A Villanueva-Najera, Laura I Sandoval-Delgadillo, M González-Lomelí, Juan H Páez-Garza, Mónica Orozco-Carroll, Mauricio Casillas-Magallanes
PURPOSE: The purpose of this study was to evaluate the clinical efficacy and safety of a novel ophthalmic solution of pazufloxacin on the ocular surface of patients with bacterial conjunctivitis after 7 days of intervention. METHODS: This is a phase 2, double-blind, controlled, multicenter, clinical trial of 300 subjects, randomized to either a 3 dosing regimen of pazufloxacin 0.6% ophthalmic solution (twice a day [BID], n = 90; 3 times a day [TID], n = 76; 4 times a day [QID], n = 68), moxifloxacin 0...
April 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29603916/phase-1-pharmacokinetics-and-phase-3-efficacy-of-testosterone-nasal-gel-in-subjects-with-seasonal-allergies
#19
Alan D Rogol, Natalia Tkachenko, Philipp Badorrek, Jens M Hohlfeld, Nathan Bryson
INTRODUCTION: NATESTO® testosterone nasal gel (TNG) is a liquid gel that is applied in the nose for the treatment of male hypogonadism. There is a reasonable concern that administration of TNG to patients with active rhinitis could modify absorption. Results from two clinical studies are reported wherein subjects with allergic rhinitis (AR) subjects are treated with TNG. METHODS: The 24-hour pharmacokinetics (PK) and relative bioavailability of serum total testosterone (sTT) from TNG (11 mg tid ) were determined using a phase 1 Latin-square design with 18 eugonadal AR subjects crossed over between asymptomatic, symptomatic-untreated, and symptomatic-treated (oxymetazoline) conditions...
March 19, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29574584/phase-i-study-of-combined-indomethacin-and-platinum-based-chemotherapy-to-reduce-platinum-induced-fatty-acids
#20
Daphne L van der Velden, Geert A Cirkel, Julia M Houthuijzen, E van Werkhoven, Jeanine M L Roodhart, Laura G M Daenen, Sovann Kaing, Johan Gerrits, Nanda M Verhoeven-Duif, Cecile Grootscholten, Henk Boot, Cristisiana Sessa, Haiko J Bloemendal, Filip Y De Vos, Emile E Voest
PURPOSE: Chemotherapy-resistance remains a major obstacle to effective anti-cancer treatment. We previously showed that platinum analogs cause the release of two fatty acids. These platinum-induced fatty acids (PIFAs) induced complete chemoresistance in mice, whereas co-administration of a COX-1 inhibitor, indomethacin, prevented PIFA release and significantly enhanced chemosensitivity. To assess the safety of combining indomethacin with platinum-based chemotherapy, and to explore its efficacy and associated PIFA levels, a multi-center phase I trial was conducted...
March 24, 2018: Cancer Chemotherapy and Pharmacology
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