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https://www.readbyqxmd.com/read/28929697/-effects-of-berberine-on-serum-inflammatory-factors-and-carotid-atherosclerotic-plaques-in-patients-with-acute-cerebral-ischemic-stroke
#1
Ying Li, Pei Wang, Mei-Jing Chai, Fan Yang, Hong-Shan Li, Jing Zhao, Huan Wang, Dan-Dan Lu
This study aims to analyze the effect of berberine on serum inflammatory factors and carotid atherosclerotic plaques in ppatients with acute cerebral ischemic stroke(AIS). In the study, 120 patients with AIS were randomly divided into berberine group(n=60) and general group (n=60). The 60 cases in the general group were provided with general therapy according to the latest guidelines of diagnosis and treatment of AIS. The berberine group received berberine 300 mg(tid) in addition to the therapy of the general group...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28898204/beneficial-effect-of-beraprost-sodium-plus-aspirin-in-the-treatment-of-acute-ischemic-stroke
#2
Siqia Chen, Sisi Xie, Wenzhen He, Duncan Wei, Shunxian Li, Wenjie Chen
BACKGROUND To investigate the combination of beraprost sodium (BPS) and aspirin in the treatment of acute ischemic stroke (AIS). MATERIAL AND METHODS 308 patients with acute cerebral infarction were randomly divided into two groups: experimental group (n=154), treated with BPS (40 μg, tid) and aspirin (100 mg, qd); control group (n=154), treated with 100 mg of aspirin, qd). The antiplatelet therapy remained unchangeable until six months after hospital discharge. RESULTS Initially, no significant differences were found between the two groups...
September 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28889759/nintedanib-with-add-on-pirfenidone-in-idiopathic-pulmonary-fibrosis-results-of-the-injourney-trial
#3
Carlo Vancheri, Michael Kreuter, Luca Richeldi, Christopher J Ryerson, Dominique Valeyre, Jan C Grutters, Sabrina Wiebe, Wibke Stansen, Manuel Quaresma, Susanne Stowasser, Wim A Wuyts
RATIONALE: Nintedanib and pirfenidone slow the progression of IPF, but the disease continues to progress. More data are needed on the safety and efficacy of combination therapy with nintedanib and add-on pirfenidone. OBJECTIVES: To investigate safety, tolerability, pharmacokinetic and exploratory efficacy endpoints in patients treated with nintedanib and add-on pirfenidone versus nintedanib alone. METHODS: Patients with IPF and FVC ≥50% predicted at screening who completed a 4-5 week run-in with nintedanib 150 mg bid without dose reduction or treatment interruption were randomized to nintedanib 150 mg bid with add-on pirfenidone (titrated to 801 mg tid), or nintedanib 150 mg bid alone, open-label for 12 weeks...
September 10, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28845828/spontaneous-dissemination-in-neighboring-provinces-of-dka-prevention-campaign-successfully-launched-in-nineties-in-parma-s-province
#4
Antonina Marta Cangelosi, Ilaria Bonacini, Roberta Pia Serra, Dora Di Mauro, Brunella Iovane, Valentina Fainardi, Carla Mastrorilli, Maurizio Vanelli
AIM: to investigate how much effectiveness of the historical campaign of DKA prevention at T1D diagnosis has survived in Parma's province where this was launched in Nineties, and how much it has spontaneously spread in the neighboring provinces. METHOD: children aged 6-14 years with newly diagnosed TID coming from province of Parma (Group 1) and from two other nearby provinces (Group 2)  were investigated. Clinical and laboratory data were retrospectively collected from medical files of each patient and included age, gender, capillary pH, serum bicarbonate, 3-beta-hydroxybutyrate (3HB), glycated hemoglobin (HbA1c) at the time of admittance from 1st January 2012 and 31 December 2016...
August 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28844562/utilization-of-cardiovascular-medicines-and-cardiovascular-mortality-in-lithuania-sweden-and-norway-in-2003-2012
#5
Ingrida Lisauskienė, Kristina Garuolienė, Jolanta Gulbinovič
OBJECTIVE: The aim of this ecological study was to evaluate whether any changes in cardiovascular (CV) medicine utilization, population, socioeconomic and health system factors were associated with CV mortality in Lithuania, Sweden and Norway in 2003-2012. MATERIALS AND METHODS: CV drug utilization was calculated using the Anatomical Therapeutic Chemical/Defined Daily Dose (DDD) methodology and expressed as a number of DDD per 1000 inhabitants per day (DDD/TID)...
July 31, 2017: Medicina
https://www.readbyqxmd.com/read/28839987/effect-of-huisheng-oral-solution-on-coagulation-function-in-perioperative-period-in-patients-with-primary-lung-cancer
#6
Xiaoguang Yang, Helin Zhang, Fanyi Kong, Guochen Wang, Qianyu Gu, Zheng Zhao, Tiezhi Li, Mingming Ren, Zuosheng Li, Yang Guo
BACKGROUND: The incidence of venous thromboembolism (VTE) is about 4-10% in lung cancer patients. Huisheng oral solution (HSOS) has been previously demonstrated to inhibit carageenan induced acute thrombosis in rats, reduce the incidence of thrombosis in the lungs and mesentery of tumor-bearing mice and inhibit tumor cell metastasis. The purpose of this study was to assess the anticoagulant effect of HSOS in lung cancer patients in the perioperative period. METHODS: This study was a multicenter, randomized, single-blind, blank-controlled clinical trial...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28814855/effect-of-carbocisteine-on-patients-with-copd-a-systematic-review-and-meta-analysis
#7
Zheng Zeng, Dan Yang, Xiaoling Huang, Zhenliang Xiao
BACKGROUND: COPD is the fourth leading cause of death in the world. It is a common, progressive, treatable and preventable disease. The exacerbation of COPD is associated with the peripheral muscle force, forced expiratory volume in 1 second (FEV1), the quality of life and mortality. Many studies indicated that the mucoactive medicines could reduce the exacerbations of COPD. This study summarized the efficacy of carbocisteine as a treatment for COPD. METHODS: We searched the randomized controlled trials (RCTs) following electronic bibliographic databases: MedLine, Embase, Cochrane Library and Web of Science...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28803673/tubulointerstitial-damage-predicts-end-stage-renal-disease-in-lupus-nephritis-with-preserved-to-moderately-impaired-renal-function-a-retrospective-cohort-study
#8
Anna Broder, Wenzhu B Mowrey, Hina N Khan, Bojana Jovanovic, Alejandra Londono-Jimenez, Peter Izmirly, Chaim Putterman
OBJECTIVES: The presence of tubulointerstitial damage (TID) on renal biopsy is considered to be a late sequela of lupus nephritis (LN). The objective of this study was to determine if TID predicts progression to end stage renal disease (ESRD) in LN patients without advanced kidney disease. METHODS: All SLE patients with an index biopsy consistent with LN between January 2005 and July 2015, and eGFR ≥ 30mL/min/1.73m(2) were included. Moderate-to-severe TID was defined as the presence of moderate-to-severe tubular atrophy and/or interstitial fibrosis...
July 14, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28760408/relationship-between-serum-inflammatory-markers-and-vascular-function-in-a-cohort-of-adolescents-with-type-1-diabetes
#9
Etienne Sochett, Damien Noone, Michael Grattan, Cameron Slorach, Rahim Moineddin, Yesmino Elia, Farid H Mahmud, David B Dunger, Neil Dalton, David Cherney, James Scholey, Heather Reich, John Deanfield
OBJECTIVE: The contribution of inflammation to endothelial/vascular dysfunction in early Type I Diabetes (T1D) is not well understood. The objective of this study was to examine the interaction between systemic inflammation and vascular function in adolescent's with and without-T1D. METHODS: 51 subjects from our observational cohort of adolescents with T1D (JDRF-CCTN), and 59 healthy controls (HC) were studied. Serum cytokines-chemokines were quantified using Human 41-Plex Array, and vascular function was measured by Flow Mediated Dilatation (FMD), Pulse Wave Velocity (PWV) and Blood Pressure (BP)...
July 28, 2017: Cytokine
https://www.readbyqxmd.com/read/28751099/efficacy-and-safety-of-delayed-release-dimethyl-fumarate-for-relapsing-remitting-multiple-sclerosis-in-prior-interferon-users-an-integrated-analysis-of-define-and-confirm
#10
Óscar Fernández, Gavin Giovannoni, Robert J Fox, Ralf Gold, J Theodore Phillips, James Potts, Macaulay Okwuokenye, Jing L Marantz
PURPOSE: In Phase III studies (DEFINE [Determination of the Efficacy and Safety of Oral Fumarate in Relapsing-Remitting MS]/CONFIRM [Comparator and an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis]), delayed-release dimethyl fumarate (DMF) demonstrated significant efficacy and a favorable benefit-risk profile in patients with relapsing-remitting multiple sclerosis (RRMS). Post hoc analyses of integrated data from DEFINE/CONFIRM were conducted to evaluate the effect of DMF in patients previously treated with interferon (IFN) beta...
July 24, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28739791/protection-of-hamsters-from-mortality-by-reducing-fecal-moxifloxacin-concentration-with-dav131a-in-a-model-of-moxifloxacin-induced-clostridium-difficile-colitis
#11
Charles Burdet, Sakina Sayah-Jeanne, Thu Thuy Nguyen, Christine Miossec, Nathalie Saint-Lu, Mark Pulse, William Weiss, Antoine Andremont, France Mentré, Jean de Gunzburg
BACKGROUND: Lowering the gut exposure to antibiotics during treatments can prevent microbiota disruption. We evaluated the effect of an activated charcoal-based adsorbent, DAV131A, on fecal free moxifloxacin concentration and mortality in a hamster model of moxifloxacin-induced C. difficile infection. METHODS: 215 hamsters receiving moxifloxacin subcutaneously (D1-D5) were orally infected at D3 with C. difficile spores. They received various doses (0-1800mg/kg/day) and schedules (BID, TID) of DAV131A (D1-D8)...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28732819/individual-dose-adjustment-of-riociguat-in-patients-with-pulmonary-arterial-hypertension-and-chronic-thromboembolic-pulmonary-hypertension
#12
REVIEW
Nicholas S Hill, Franck F Rahaghi, Namita Sood, Reiner Frey, Hossein-Ardeschir Ghofrani
Riociguat is a soluble guanylate cyclase stimulator that has been approved for the treatment of pulmonary arterial hypertension and inoperable chronic thromboembolic pulmonary hypertension or persistent/recurrent pulmonary hypertension following pulmonary endarterectomy. Riociguat is administered using an 8-week individual dose-adjustment scheme whereby a patient initially receives riociguat 1.0 mg three times daily (tid), and the dose is then increased every 2 weeks in the absence of hypotension, indicated by systolic blood pressure measurements and symptoms, up to a maximum dose of 2...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28727555/tid-introducing-and-benchmarking-an-event-delivery-system-for-brain-computer-interfaces
#13
Christian Breitwieser, Michele Tavella, Martijn Schreuder, Febo Cincotti, Robert Leeb, Gernot R Muller-Putz
In this paper, we present and analyze an event distribution system for brain-computer interfaces (BCIs). Events are commonly used to mark and describe incidents during an experiment and are therefore critical for later data analysis or immediate real-time processing. The presented approach, called TiD (Tools for brain-computer interaction - interface D), delivers messages in XML format via a bus-like system using TCP (transmission control protocol) connections or shared memory. A dedicated server dispatches TiD messages to distributed or local clients...
July 18, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28727030/apparent-and-true-ileal-and-total-tract-digestibility-of-fat-in-canola-press-cake-or-canola-oil-and-effects-of-increasing-dietary-fat-on-amino-acid-and-energy-digestibility-in-growing-pigs
#14
X Zhou, E Beltranena, R T Zijlstra
Digestibility of remaining oil in canola press-cake (CPC) may be lower than that of extracted, liquid canola oil (CO) because oil may be partly entrapped in the CPC matrix. To determine true digestibility of fat in ingredients, endogenous fat losses should be estimated. Dietary fat may interact with digestion of other dietary components. To test these hypotheses, 10 ileal-cannulated pigs (initial BW, 25.4 kg) were fed 10 diets for 8 periods in a 10 × 8 Youden square. A basal diet was formulated based on wheat, barley, and canola meal...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28706400/hybrid-therapy-versus-sequential-therapy-for-eradication-of-helicobacter-pylori-a-randomized-controlled-trial
#15
Sahoo Ashokkumar, Sonia Agrawal, Jharna Mandal, Sathasivam Sureshkumar, Gubbi Shamanna Sreenath, Vikram Kate
OBJECTIVE: To compare the sequential therapy (ST) with the hybrid therapy (HT) for the eradication of Helicobacter pylori. MATERIALS AND METHODS: Patients with peptic ulcer disease and gastritis found to be H. pylori positive were randomized to HT group who received omeprazole (20 mg bid) and amoxicillin (1 g bid) for 7 days followed by omeprazole (20 mg bid), amoxicillin (1 g bid), clarithromycin (500 mg bid), and metronidazole (400 mg tid) for the next 7 days and ST group who received omeprazole and amoxicillin for 5 days followed by omeprazole, clarithromycin, and metronidazole for the next 5 days...
April 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28701963/hoarding-disorder-a-case-report
#16
Daniela Vilaverde, Jorge Gonçalves, Pedro Morgado
Hoarding disorder is characterized by a persistent difficulty discarding items, the desire to save items to avoid negative feelings associated with discarding them, significant accumulation of possessions that clutter active living areas and significant distress or impairment in areas of functioning. We present a case of a 52-year-old married man who was referred to the psychiatry department for collecting various objects that were deposited unorganized in the patient's house. He reported to get anxious when someone else discarded some of these items...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28699274/transplant-center-support-for-infectious-diseases
#17
Joanna M Schaenman, Deepali Kumar, Camille N Kotton, Lara Danziger-Isakov, Michele I Morris
BACKGROUND: Transplant Infectious Diseases (TID) is a rapidly growing subspecialty, which has contributed significantly to improving patient outcomes after transplantation. Obtaining institutional support to implement programs that promote excellence in patient care remains a challenge for many non-surgical transplant-related specialties. METHOD: We surveyed the membership of the American Society of Transplantation Infectious Diseases Community of Practice to assess characteristics of individual transplant programs and delineate current patterns of institutional support of TID, with a goal of facilitating the exchange of innovative funding ideas between transplant programs...
July 12, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28670181/transient-ischemic-dilation-ratio-in-regadenoson-single-isotope-gated-single-photon-emission-computed-tomography-myocardial-perfusion-imaging
#18
Manolo Rubio, Andre Dias, Nikoloz Koshkelashvili, Jose N Codolosa, Mauricio Jalife-Bucay, Mary Rodriguez-Ziccardi, Aman M Amanullah
Single isotope 99mTc single-photon emission computed tomography-myocardial perfusion imaging (SPECT-MPI) is the most commonly used protocol for nuclear stress testing. Transient ischemic dilation of the left ventricle (TID) has been considered a specific marker of severe coronary artery disease (CAD). Recent publications have questioned the clinical utility of TID, specifically with regadenoson as a stressor and 4DM-SPECT software for TID analysis. These findings have not been demonstrated using other imaging packages...
July 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28669739/an-evidence-based-recommendation-to-increase-the-dosing-frequency-of-buprenorphine-during-pregnancy
#19
Steve N Caritis, Jaime R Bastian, Hongfei Zhang, Hari Kalluri, Dennis English, Michael England, Stephanie Bobby, Raman Venkataramanan
BACKGROUND: Dose-adjusted plasma concentrations of buprenorphine are significantly decreased during pregnancy compared with the nonpregnant state. This observation suggests that pregnant women may need a higher dose of buprenorphine than nonpregnant individuals to maintain similar drug exposure (plasma concentrations over time after a dose). The current dosing recommendations for buprenorphine during pregnancy address the total daily dose of buprenorphine to be administered, but the frequency of dosing is not clearly addressed...
June 29, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28665371/-results-of-a-randomized-double-blind-multicenter-placebo-controlled-in-parallel-groups-trial-of-the-efficacy-and-safety-of-prolonged-sequential-therapy-with-mexidol-in-the-acute-and-early-recovery-stages-of-hemispheric-ischemic-stroke-epica
#20
L V Stakhovskaya, N A Shamalov, D R Khasanova, E V Melnikova, A S Agafiina, K V Golikov, E I Bogdanov, A A Yakupova, L V Roshkovskaya, L V Lukinykh, T M Lokshtanova, I E Poverennova, L A Shepankevich
AIM: To evaluate the efficacy and safety of prolonged sequential therapy with mexidol in the acute and early recovery stages of hemispheric ischemic stroke (IS). MATERIAL AND METHODS: A randomized double blind multicenter placebo-controlled, in parallel groups trial included 151 patients (62 men and 89 women) with hemispheric IS. Using a method of simple randomization, 150 patients (62 men and 88 women), aged 40-79 years, were randomized into two groups. Patients of Group I were treated with mexidol: 500 mg/day IV infusion for 10 days, followed by 125 mg tid (375 mg/day) PO for 8 weeks...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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