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lung reconditioning

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https://www.readbyqxmd.com/read/27917620/normothermic-ex-vivo-lung-perfusion-in-brain-dead-donors-reduces-inflammatory-cytokines-and-toll-like-receptor-expression
#1
Shadi Shafaghi, Esmaeil Mortaz, Azizollah Abbasi Dezfuli, Hoda Godarzi, Kambiz Sheikhy, Zahra Ansari Aval, Behrooz Farzanegan, Habib Emami, Fatemeh Sadat Hosseini-Baharanchi, Katayoun Najafizadeh
Inflammatory responses and innate immunologic reactions play an important role in the respiratory system. Ex vivo lung perfusion (EVLP) is considered a novel method in the evaluation and reconditioning of donor lungs prior to transplantation. However, EVLP's effect on inflammatory and metabolic markers of human lung tissue is unknown.  This study investigated how the performance of EVLP on brain-dead (BD) donor lungs affects the production and release of inflammatory cytokines (IL-6, IL-8, and TNF-a), inflammatory cells and toll-like receptors (TLR) -2, 4...
October 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27897967/an-observational-study-of-donor-ex-vivo-lung-perfusion-in-uk-lung-transplantation-develop-uk
#2
Andrew Fisher, Anders Andreasson, Alexandros Chrysos, Joanne Lally, Chrysovalanto Mamasoula, Catherine Exley, Jennifer Wilkinson, Jessica Qian, Gillian Watson, Oli Lewington, Thomas Chadwick, Elaine McColl, Mark Pearce, Kay Mann, Nicola McMeekin, Luke Vale, Steven Tsui, Nizar Yonan, Andre Simon, Nandor Marczin, Jorge Mascaro, John Dark
BACKGROUND: Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use. OBJECTIVE: The objective of the Donor Ex Vivo Lung Perfusion in UK lung transplantation study was to evaluate the clinical effectiveness and cost-effectiveness of EVLP in increasing UK lung transplant activity. DESIGN: A multicentre, unblinded, non-randomised, non-inferiority observational study to compare transplant outcomes between EVLP-assessed and standard donor lungs...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27737734/bronchodilator-inhalation-during-ex%C3%A2-vivo-lung-perfusion-improves-posttransplant-graft-function-after-warm-ischemia
#3
Kyoko Hijiya, Toyofumi F Chen-Yoshikawa, Takeshi Kondo, Hideki Motoyama, Akihiro Ohsumi, Daisuke Nakajima, Jin Sakamoto, Keiji Ohata, Mamoru Takahashi, Satona Tanaka, Ei Miyamoto, Akihiro Aoyama, Hiroshi Date
BACKGROUND: We hypothesized that an injured lung graft from donation after cardiac death donors could be reconditioned before transplantation using an ex vivo lung perfusion (EVLP) system and ventilation with high-dose short-acting β2-adrenergic receptor agonists. METHODS: Cardiac arrest was induced in a canine model by intravenous potassium chloride injection. Lungs were randomly assigned to two groups after 150 minutes of warm ischemia: inhalation of 1,400 μg of procaterol (BETA group, n = 5) or control group receiving solvent (CON group, n = 5) during EVLP...
October 10, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27424500/improving-donor-lung-suitability-from-protective-strategies-to-ex-vivo-reconditioning
#4
Paolo Solidoro, Annia Schreiber, Massimo Boffini, Fulvio Braido, Fabiano DI Marco
Lung transplant is a therapeutic option for end stage lung diseases, but only a limited number of lung grafts is considered suitable for transplantation. It has been recently suggested an approach to improve and maximize donor lung suitability, namely ventilation strategies to prevent lung damage and preserve function before transplantation. In potential lung donor patients, the use of lung-protective ventilatory strategies may protect against and at least partially reverse some conditions, such as ventilator-induced lung injury, atelectasis and neurogenic pulmonary edema, resulting in improved donor organ procurement...
June 2016: Minerva Medica
https://www.readbyqxmd.com/read/27331361/pharmacological-reconditioning-of-marginal-donor-rat-lungs-using-inhibitors-of-peroxynitrite-and-poly-adp-ribose-polymerase-during-ex-vivo-lung-perfusion
#5
Xingyu Wang, Yabo Wang, Roumen Parapanov, Etienne Abdelnour, Fabrizio Gronchi, Jean Yannis Perentes, Lise Piquilloud, Hans-Beat Ris, Igor Letovanec, Lucas Liaudet, Thorsten Krueger
BACKGROUND: Donor lungs obtained after prolonged warm ischemia (WI) may be unsuitable for transplantation due to the risk of reperfusion injury, but could be reconditioned using ex-vivo lung perfusion (EVLP). Key processes of reperfusion injury include the formation of reactive oxygen species (ROS)/nitrogen species (RNS) and the activation of poly(adenosine diphosphate-ribose) polymerase (PARP). We explored whether rat lungs obtained after WI could be reconditioned during EVLP using the ROS/RNS scavenger Mn(III)-tetrakis (4-benzoic acid) porphyrin chloride (MnTBAP) or the PARP inhibitor 3-aminobenzamide (3-AB)...
July 2016: Transplantation
https://www.readbyqxmd.com/read/27308868/improving-donor-lung-suitability-from-protective-strategies-to-ex-vivo-reconditioning
#6
Paolo Solidoro, Annia Schreiber, Massimo Boffini, Fulvio Braido, Fabiano DI Marco
Lung transplant is a therapeutic option for end stage lung diseases, but only a limited number of lung grafts is considered suitable for transplantation. It has been recently suggested an approach to improve and maximize donor lung suitability, namely ventilation strategies to prevent lung damage and preserve function before transplantation. In potential lung donor patients, the use of lung-protective ventilatory strategies may protect against and at least partially reverse some conditions, such as ventilator-induced lung injury, atelectasis and neurogenic pulmonary edema, resulting in improved donor organ procurement...
June 15, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27167429/ex-vivo-lung-perfusion-in-brazil
#7
Luis Gustavo Abdalla, Karina Andrighetti de Oliveira Braga, Natalia Aparecida Nepomuceno, Lucas Matos Fernandes, Marcos Naoyuki Samano, Paulo Manuel Pêgo-Fernandes
OBJECTIVE: To evaluate the use of ex vivo lung perfusion (EVLP) clinically to prepare donor lungs for transplantation. METHODS: A prospective study involving EVLP for the reconditioning of extended-criteria donor lungs, the criteria for which include aspects such as a PaO2/FiO2 ratio < 300 mmHg. Between February of 2013 and February of 2014, the lungs of five donors were submitted to EVLP for up to 4 h each. During EVLP, respiratory mechanics were continuously evaluated...
April 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27109193/attenuation-of-pulmonary-ischemia-reperfusion-injury-by-adenosine-a2b-receptor-antagonism
#8
Mary E Huerter, Ashish K Sharma, Yunge Zhao, Eric J Charles, Irving L Kron, Victor E Laubach
BACKGROUND: Ischemia-reperfusion injury (IRI) is a major source of morbidity and mortality after lung transplantation. We previously demonstrated a proinflammatory role of adenosine A2B receptor (A2BR) in lung IR injury. The current study tests the hypothesis that A2BR antagonism is protective of ischemic lungs after in vivo reperfusion or ex vivo lung perfusion (EVLP). METHODS: Mice underwent lung IR with or without administration of ATL802, a selective A2BR antagonist...
August 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27098493/improving-donor-lung-suitability-from-protective-strategies-to-ex-vivo-reconditioning
#9
Paolo Solidoro, Annia Schreiber, Massimo Boffini, Fulvio Braido, Fabiano DI Marco
Lung transplant is a therapeutic option for end stage lung diseases but only a limited number of lung grafts is considered suitable for transplantation. It has been recently suggested an approach to improving and maximizing donor lung suitability, namely ventilation strategies to prevent lung damage and preserve function before transplantation. In potential lung donor patients, the use of lung-protective ventilatory strategies may protect against and at least partially reverse some conditions, such as ventilator-induced lung injury, atelectasis and neurogenic pulmonary edema, resulting in improved donor organ procurement...
April 21, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27093377/role-of-inflammatory-cells-and-adenosine-in-lung-ischemia-reoxygenation-injury-using-a-model-of-lung-donation-after-cardiac-death
#10
Hassiba Smail, Jean-Marc Baste, Arnaud Gay, Hugues Begueret, Romain Noël, Jean-Paul Morin, Pierre-Yves Litzler
AIM: The objective of this study is to analyze the role of inflammation in the lung ischemia reperfusion (IR) injury and determine the protective role of adenosine in an in vitro lung transplantation model. MATERIALS AND METHODS: We used a hybrid model of lung donor after cardiac death, with warm ischemia in corpo of varying duration (2 h, 4 h) followed by in vitro lung slices culture for reoxygenation (1 h, 4 h and 24 h), in the presence or not of lymphocytes and of adenosine...
April 2016: Experimental Lung Research
https://www.readbyqxmd.com/read/27083947/ex-vivo-pulmonary-nodule-detection-with-miniaturized-ultrasound-convex-probes
#11
COMPARATIVE STUDY
Niccolò Daddi, Elisabetta Sagrini, Marialuisa Lugaresi, Ottorino Perrone, Piero Candoli, Mark Ragusa, Francesco Puma, Sandro Mattioli
BACKGROUND: The intraoperative localization of small and deep pulmonary nodules is often difficult during minimally invasive thoracic surgery. We compared the performance of three miniaturized ultrasound (US) convex probes, one of which is currently used for thoracic endoscopic diagnostic procedures, for the detection of lung nodules in an ex vivo lung perfusion model. METHODS: Three porcine cardiopulmonary blocks were perfused, preserved at 4°C for 6 h and reconditioned...
May 1, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/26850183/argon-and-xenon-ventilation-during-prolonged-ex-vivo-lung-perfusion
#12
An Martens, Matteo Montoli, Giulio Faggi, Ira Katz, Jan Pype, Bart M Vanaudenaerde, Dirk E M Van Raemdonck, Arne P Neyrinck
BACKGROUND: Evidence supports the use of ex vivo lung perfusion (EVLP) as a platform for active reconditioning before transplantation to increase the potential donor pool and to reduce the incidence of primary graft dysfunction. A promising reconditioning strategy is the administration of inhaled noble gases based on their organoprotective effects. Our aim was to validate a porcine warm ischemic lung injury model and investigate postconditioning with argon (Ar) or xenon (Xe) during prolonged EVLP...
March 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/26681580/flt3-ligand-improves-the-innate-response-to-respiratory-syncytial-virus-and-limits-lung-disease-upon-rsv-reexposure-in-neonate-mice
#13
Aude Remot, Delphyne Descamps, Luc Jouneau, Daphné Laubreton, Catherine Dubuquoy, Stephan Bouet, Jérôme Lecardonnel, Emmanuelle Rebours, Agnès Petit-Camurdan, Sabine Riffault
Respiratory syncytial virus (RSV) causes severe bronchiolitis in infants worldwide. The immunological factors responsible for RSV susceptibility in infants are poorly understood. Here, we used the BALB/c mouse model of neonatal RSV infection to study the mechanisms leading to severe disease upon reexposure to the virus when adults. Two major deficiencies in neonatal lung innate responses were found: a poor DCs mobilization, and a weak engagement of the IFNI pathway. The administration of Flt3 ligand (Flt3-L), a growth factor that stimulates the proliferation of hematopoietic cells, to neonates before RSV-infection, resulted in increased lung DC number, and reconditioned the IFNI pathway upon RSV neonatal infection...
April 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/26651884/organotypic-lung-culture-a-new-model-for-studying-ischemia-and-ex-vivo-perfusion-in-lung-transplantation
#14
Jean-Marc Baste, Arnaud Gay, Hassiba Smail, Romain Noël, Michael Bubenheim, Hugues Begueret, Jean-Paul Morin, Pierre-Yves Litzler
AIM: Donors after cardiac death (DCD) in lung transplantation is considered as a solution for organ shortage. However, it is characterized by warm ischemic period, which could be involved in severe Ischemia-Reperfusion lesion (IR) with early graft dysfunction. We describe a new hybrid model combining in vivo ischemia followed by in vitro reoxygenation using organ-specific culture. MATERIAL AND METHODS: A hybrid model using in vivo ischemic period followed by in vitro lung slice reoxygenation was set up in rat to mimic DCD in lung transplantation with in vitro perfusion...
2015: Experimental Lung Research
https://www.readbyqxmd.com/read/26412634/translational-insights-on-lung-transplantation-learning-from-immunology
#15
REVIEW
Mohamed Shehata Ali Mohamed
The introduction of ex vivo lung perfusion (EVLP) in the practice of lung transplantation has allowed the reconditioning of the marginal grafts and their conversion into transplantable grafts. In addition, EVLP can provide a platform for the application of various preventive measures to decrease the incidence of post-transplant complications. While the Toronto team targets the attenuation of the cytokine production within the graft through gene therapy to up-regulate IL-10, other measures could be applied to achieve significant attenuation of the cytokine load of the graft...
September 2015: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/26346003/a-neutrophil-elastase-inhibitor-improves-lung-function-during-ex-vivo-lung-perfusion
#16
Masaaki Harada, Takahiro Oto, Shinji Otani, Kentaroh Miyoshi, Masanori Okada, Norichika Iga, Hitoshi Nishikawa, Seiichiro Sugimoto, Masaomi Yamane, Shinichiro Miyoshi
OBJECTIVE: Ex vivo lung perfusion (EVLP) has been used not only for graft evaluation but also for graft reconditioning prior to lung transplantation. Inflammatory cells such as neutrophils may cause additional graft injury during EVLP. Neutrophil elastase inhibitors protect lungs against neutrophil-induced lung injury, such as acute respiratory distress syndrome. This study aimed to investigate the effect of a neutrophil elastase inhibitor during EVLP. METHODS: EVLP was performed for 4 h in bilateral pig lungs that had previously experienced warm ischemia for 2 h with or without a neutrophil elastase inhibitor (treated and control groups, respectively; n = 6)...
December 2015: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26266913/a-standardized-model-of-brain-death-donor-treatment-and-lung-transplantation-for-studies-on-organ-preservation-and-reconditioning
#17
Franco Valenza, Silvia Coppola, Sara Froio, Giulia Maria Ruggeri, Jacopo Fumagalli, Alessandro Maria Villa, Lorenzo Rosso, Paolo Mendogni, Grazia Conte, Caterina Lonati, Andrea Carlin, Patrizia Leonardi, Stefano Gatti, Nino Stocchetti, Luciano Gattinoni
BACKGROUND: We set a model of brain death, donor management, and lung transplantation for studies on lung preservation and reconditioning before transplantation. METHODS: Ten pigs (39.7 ± 5.9 Kg) were investigated. Five animals underwent brain death and were treated as organ donors; the lungs were then procured and cold stored (Ischemia). Five recipients underwent left lung transplantation and post-reperfusion follow-up (Graft). Cardiorespiratory and metabolic parameters were collected...
December 2014: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/26262464/expanding-the-lung-donor-pool-advancements-and-emerging-pathways
#18
REVIEW
Jeremie Reeb, Shaf Keshavjee, Marcelo Cypel
PURPOSE OF REVIEW: The number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of a shortage of organ donors and a low utilization rate of lungs from those donors who are available. In recent years, novel strategies have been developed to increase the donor lung pool: improved donor management, the use of lungs from donations after cardiac death (DCD), the use of lobar lung living-donors (LLLD) and the use of ex-vivo lung perfusion (EVLP) to assess and repair injured donor lungs...
October 2015: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/26219590/hemofiltration-in-ex-vivo-lung-perfusion-a-study-in-experimentally-induced-pulmonary-edema
#19
Tobias Nilsson, Christoffer Hansson, Andreas Wallinder, Carl-Johan Malm, Martin Silverborn, Sven-Erik Ricksten, Göran Dellgren
OBJECTIVES: Ex vivo lung perfusion (EVLP) can potentially reduce pulmonary edema. In a pig model with induced pulmonary edema, we evaluated the effect of hemofiltration (HF) during EVLP on lung function, perfusate oncotic pressure, and lung weight. METHODS: In anesthetized pigs (n = 14), pulmonary edema was induced by a balloon in the left atrium, combined with crystalloid infusion (20 mL/kg), for 2 hours. The lungs were harvested, stored cold for 2 hours, and randomized to EVLP, with or without a hemofilter (HF and noHF groups, respectively, n = 7 for each)...
February 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26154550/lung-transplantation
#20
REVIEW
José Eduardo Afonso Júnior, Eduardo de Campos Werebe, Rafael Medeiros Carraro, Ricardo Henrique de Oliveira Braga Teixeira, Lucas Matos Fernandes, Luis Gustavo Abdalla, Marcos Naoyuki Samano, Paulo Manuel Pêgo-Fernandes
Lung transplantation is a globally accepted treatment for some advanced lung diseases, giving the recipients longer survival and better quality of life. Since the first transplant successfully performed in 1983, more than 40 thousand transplants have been performed worldwide. Of these, about seven hundred were in Brazil. However, survival of the transplant is less than desired, with a high mortality rate related to primary graft dysfunction, infection, and chronic graft dysfunction, particularly in the form of bronchiolitis obliterans syndrome...
April 2015: Einstein
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