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Laura Sawiak, Katherine Bailes, David Harbottle, Paul S Clegg
It has previously been demonstrated that particle-stabilized emulsions comprised of limonene, water and fumed silica particles exhibit complex emulsification behavior as a function of composition and the duration of the emulsification step. Most notably the system can invert from being oil-continuous to being water-continuous under prolonged mixing. Here we investigate this phenomenon experimentally for the regime where water is the majority liquid. We prepare samples using a range of different emulsification times and we examine the final properties in bulk and via confocal microscopy...
2018: Frontiers in Chemistry
Nagaraju Chinthakunta, Srinivasulu Cheemanapalli, Surekha Chinthakunta, C M Anuradha, Suresh Kumar Chitta
G-protein coupled receptor (GPR120) is an omega-3 fatty acid receptor that inhibits macrophage-induced tissue inflammation. Recent studies revealed GPR120 promotes colorectal carcinoma through modulation of VEGF, IL-8, PGE2, and NF-kB expression. However, three-dimensional structure of GPR120 is not yet available in Protein Data Bank (PDB). In the present study, we focused on a 3-D structural model of GPR120 has been constructed using homology modeling techniques. The structural quality of the predicted GPR120 model was verified using Procheck, Whatif, ProSA, and Verify 3D...
2018: Network Modeling and Analysis in Health Informatics and Bioinformatics
Nemesio Villa-Ruano, Yesenia Pacheco-Hernández, Elvia Becerra-Martínez, José Alejo Zarate-Reyes, Ramiro Cruz-Duran
This study reports on the volatile profile and pharmacological activities of the essential oil and resin from Bursera slechtendalii, an aromatic medicinal tree commercialized in southern Mexico. The essential oil contained 25 volatiles including p-cymen-8-ol (25.4-35.7%), n-hexyl hexanoate (6.8-17.6%) and n-octyl hexanoate (7.6-14.8%), whereas the crystallized resin contained 14 volatiles, including n-octyl acetate (29.6-34.2%), limonene (15.8-18.7%) and n-octyl butyrate (12.6-17-6%). The inhalation of vapors from the resin and essential oil caused a significant anxiolytic-like effect (p < ...
May 16, 2018: Fitoterapia
Charaf Eddine Watheq Malti, Maghnia Boussaïd, Larbi Belyagoubi, Mathieu Paoli, Marc Gibernau, Félix Tomi, Fewzia Atik Bekkara, Chahrazed Bekhechi
The chemical composition of 93 oils amples from the aerial parts of Pituranthos scoparius,harvested in three regions of Algeria, was investigated by GC(FID), GC/MS and 13 C-NMR. Monoterpene hydrocarbons were dominating in association with phenylpropanoids and a chemical variability was found highlighting three clusters. The composition of group I (36 samples) exhibited an atypical composition characterized by a very high contents of 6-methoxy elemicine (13.0-59.6%), followed by sabinene (1.1-43.0%) and limonene (6...
May 17, 2018: Chemistry & Biodiversity
Chang Yeol Yang, Junheon Kim, Hyeong-Hwan Kim
The ambrosia beetle, Xyleborinus saxesenii Ratzeburg (Coleoptera: Curculionidae, Scolytinae), infests physiologically stressed apple and peach trees in Korea. Dispersing females utilize the degradation product ethanol and host-related volatiles to locate and colonize new host trees. We examined the extent to which 12 chemicals emitted from fruit trees act synergistically with ethanol to attract X. saxesenii. The addition of benzaldehyde to ethanol significantly increased beetle attraction, although benzaldehyde was not attractive by itself...
May 15, 2018: Journal of Economic Entomology
Qi He, Wenxia Wang, Liang Zhu
BACKGROUND: Zanthoxylum acanthopodium has insecticidal effect in Chinese traditional medicine. In this study, the essential oil from the dried Zanthoxylum plant was used as a larvicidal compound against the malaria mosquitoes, Anopheles anthropophagus and Anopheles sinensis. METHODS: Compounds in the Zanthoxylum essential oil were investigated by gas chromatography and mass spectroscopy (GC-MS). The larvicidal bioassays of the whole oil, as well as the main compounds in the oil (estragole and eucalyptol) were performed using WHO method...
May 15, 2018: Malaria Journal
Priscilla Porto-Figueira, Jorge A M Pereira, José S Câmara
The worldwide high cancer incidence and mortality demands for more effective and specific diagnostic strategies. In this study, we evaluated the efficiency of an innovative methodology, Needle Trap Microextraction (NTME), combined with gas chromatography-mass spectrometry (GC-MS), for the establishment of the urinary volatomic biosignature from breast (BC), and colon (CC) cancer patients as well as healthy individuals (CTL). To achieve this, 40 mL of the headspace of acidified urine (4 mL, 20% NaCl, pH = 2), equilibrated at 50 °C during 40 min, were loaded through the DVB/Car1000/CarX sorbent inside the NTD, and subjected to a GC-MS analysis...
September 6, 2018: Analytica Chimica Acta
Negin Farshchi, Ali Abbasian, Kambiz Larijani
Limonene is a colorless liquid hydrocarbon and had been investigated as a plasticizer for many plastics. Prediction of solubility between different materials is an advantage in many ways, one of the most convenient ways to know the compatibility of materials is to determine the degree of solubility of them in each other. The concept of "solubility parameter" can help practitioners in this way.In this study, inverse gas chromatography (IGC) method at infinite dilution was used for determination of the thermodynamic properties of DL-p-mentha-1,8-diene, 4-Isopropyl-1-methylcyclohexene (DL-limonene)...
May 10, 2018: Journal of Chromatographic Science
Pablo Luis B Figueiredo, Renan C Silva, Joyce Kelly R da Silva, Chieno Suemitsu, Rosa Helena V Mourão, José Guilherme S Maia
BACKGROUND: Psidium guineense, known as Araçá, is a Brazilian botanical resource with commercial application perspectives, based on the functional elements of its fruits and due to the use of its leaves as an anti-inflammatory and antibacterial agent. The essential oils of leaves of twelve specimens of Araçá were analyzed by GC and GC-MS to identify their volatile constituents and associate them with the biological activities reputed to the plant. RESULTS: In a total of 157 identified compounds, limonene, α-pinene, β-caryophyllene, epi-β-bisabolol, caryophyllene oxide, β-bisabolene, α-copaene, myrcene, muurola-4,10(14)-dien-1-β-ol, β-bisabolol, and ar-curcumene were the primary components in descending order up to 5%...
May 10, 2018: Chemistry Central Journal
Thalita Dallapícula Ramos, Miguel de la Guardia, Agustín Pastor, Francesc A Esteve-Turrillas
A calibration chamber has been designed and employed for the simple and easy determination of uptake sampling rate (RS ) of volatile organic compounds (VOCs) from air using passive samplers. A flow of clean air was continuously spiked, at a constant VOC concentration, by the microinjection of a standard solution by means of a T-type tube. The developed system allowed the complete evaporation at room temperature of the standard solution in acetone and the air concentration of VOCs was easily controlled by the regulation of the clean air flow, the standard solution concentration and its flow...
April 1, 2018: Science of the Total Environment
Mohamed Ahmed El-Nabarawi, Rehab Nabil Shamma, Faten Farouk, Samar Mohamed Nasralla
Dapsone (DPS) is a unique sulfone with antibiotic and anti-inflammatory activity. Owing to its dual action, DPS has a great potential to treat acne. Topical DPS application is expected to be effective in treatment of mild to moderate acne conditions. Invasomes are novel vesicles composed of phosphatidylcholine, ethanol, and one or mixture of terpenes of enhanced percutaneous permeation. In this study, DPS-loaded invasomes were prepared using the thin film hydration technique. The effect of different terpenes (Limonene, Cineole, Fenchone, and Citral) in different concentrations on the properties of the prepared DPS-loaded invasomes was investigated using a full factorial experimental design, namely, the particle size, drug entrapment, and release efficiency...
May 3, 2018: AAPS PharmSciTech
Munir S Obbed, Ahmad Aqel, Z A Al Othman, A-Yacine Badjah-Hadj-Ahmed
Application of monolithic columns in gas chromatography is still considered very limited. In this work, several polymethacrylate-based monolithic capillary columns were fabricated, characterized and used in gas chromatography. The five monomers used were: methyl methacrylate, (MMA), hexyl methacrylate (HMA), glycidyl methacrylate (GMA), 2-butoxyethyl methacrylate (BEMA) and isobornyl methacrylate (IBMA), while ethylene dimethacrylate was the crosslinker. The monoliths were synthesized in 30 cm length capillaries possessing inner diameters (i...
April 23, 2018: Journal of Chromatography. A
Edinson Puentes-Cala, Manuel Liebeke, Stephanie Markert, Jens Harder
The enzymatic functionalization of hydrocarbons is a central step in the global carbon cycle initiating the mineralization of methane, isoprene and monoterpenes, the most abundant biologically produced hydrocarbons. Also, terpene-modifying enzymes have found many applications in the energy-economic biotechnological production of fine chemicals. Here we describe a limonene dehydrogenase that was purified from the facultatively anaerobic betaproteobacterium Castellaniella defragrans 65Phen grown on monoterpenes under denitrifying conditions in the absence of molecular oxygen...
May 1, 2018: Journal of Biological Chemistry
Sanushka Naidoo, Nanette Christie, Juan José Acosta, Makobatjatji M Mphahlele, Kitt G Payn, Alexander A Myburg, Carsten Külheim
Leptocybe invasa is an insect pest causing gall formation on oviposited shoot tips and leaves of Eucalyptus trees leading to leaf deformation, stunting and death in severe cases. We previously observed different constitutive and induced terpenes, plant specialised metabolites that may act as attractants or repellents to insects, in a resistant and susceptible clone of Eucalyptus challenged with L. invasa. We tested the hypothesis that specific terpenes are associated with pest resistance in a Eucalyptus grandis half-sib population...
April 30, 2018: Plant, Cell & Environment
Juliah W Jacob, David P Tchouassi, Zipporah O Lagat, Evan M Mathenge, Collins K Mweresa, Baldwyn Torto
Several studies have shown that odors of plant and animal origin can be developed into lures for use in surveillance of mosquito vectors of infectious diseases. However, the effect of combining plant- and mammalian-derived odors into an improved lure for monitoring both nectar- and blood-seeking mosquito populations in traps is yet to be explored. Here we used both laboratory dual choice olfactometer and field assays to investigate responses of the malaria vector, Anopheles gambiae, to plant- and mammalian-derived compounds and a combined blend derived from these two odor sources...
April 27, 2018: Acta Tropica
T Suzuki, T Uchino, I Hatta, Y Miyazaki, S Kato, K Sasaki, Y Kagawa
BACKGROUND: The aim of this study was to investigate whether the lamellar and lateral structure of intercellular lipid of stratum corneum (SC) can be evaluated from millimeter-sized SC (MSC) by X-ray diffraction. MATERIALS AND METHODS: A 12 mm × 12 mm SC sheet from hairless mouse was divided into 16 pieces measuring 3 mm × 3 mm square. From another sheet, 4 pieces of ultramillimeter-sized SC (USC:1.5 mm × 1.5 mm square) were prepared. Small and wide-angle X-ray diffraction (SAXD and WAXD) measurements were performed on each piece...
April 29, 2018: Skin Research and Technology
Luis Eduardo Ferreira, Bruno Iglesias Benincasa, Ana Lúcia Fachin, Silvia Helena Taleb Contini, Suzelei Castro França, Ana Carolina Souza Chagas, Rene Oliveira Beleboni
BACKGROUND: Infections of sheep with gastrointestinal parasites, especially Haemonchus contortus, have caused serious losses in livestock production, particularly after the emergence of resistance to conventional anthelmintics. The search for new anthelmintic agents, especially those of botanical origin, has grown substantially due to the perspective of less contamination of meat and milk, as well as other advantages related to their cost and accessibility in less developed countries...
April 25, 2018: Parasites & Vectors
Worranan Rangsimawong, Paisit Wattanasri, Prasopchai Tonglairoum, Prasert Akkaramongkolporn, Theerasak Rojanarata, Tanasait Ngawhirunpat, Praneet Opanasopit
The purpose of this research was to develop microemulsions (ME) and microemulgels (MG) for enhancing transdermal delivery of Kaempferia parviflora (KP) extract. The methoxyflavones were used as markers. Various formulations of ME and MG containing 10% w/v KP extract were prepared, and the in vitro skin permeation and deposition were investigated. The potential ME system containing oleic acid (5% w/v), Tween 20 (20% w/v), PG (40% w/v), and water (35% w/v) was successfully formulated. ME with 10% w/v limonene (ME-L10%) showed higher methoxyflavones flux than ME-L5%, ME-L1%, ME without limonene, and KP extract in water, respectively...
April 23, 2018: AAPS PharmSciTech
Bruna Dos Santos Rodrigues, Renato Ivan de Ávila, Polyana Lopes Benfica, Ludmila Pires Bringel, Cecília Maria Alves de Oliveira, Fábio Vandresen, Cleuza Conceição da Silva, Marize Campos Valadares
AIMS: This study evaluated parameters of toxicity and antiproliferative effects of (+)-N(1)-4-fluorobenzaldehyde-N(4)-{1-methyl-1-[(1R)-4-methylcyclohexene-3-il]-ethyl}-thiossemicarbazone (4-FTSC) in PC-3 adenocarcinoma prostate cells. MAIN METHODS: Cytotoxicity of 4-FTSC in PC-3 cells was evaluated using MTT assay. Morphology examination of PC-3 cells treated with 4-FTSC was also performed as well as the cell death mechanisms induced were investigated using flow cytometry...
April 16, 2018: Life Sciences
Laurence Jacquot, Jean-Louis Millot, Aurore Colette Paillard
BACKGROUND: Individuals who experience motion sickness (MS) frequently mention the presence of smells in the environment as a factor favoring the occurrence of MS symptoms. The aim of the present work was to compare olfactory function in MS sensitive (MS+) and insensitive (MS-) subjects. METHODS: Olfactory testing included determination of odor detection thresholds, subjective evaluation of the quality (intensity, hedonicity, and familiarity) of three different odorants (limonene, isovaleric acid, and petrol) as well as measures of skin conductance responses to these three odorants...
May 1, 2018: Aerospace Medicine and Human Performance
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