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https://www.readbyqxmd.com/read/28105133/a-prospective-study-to-evaluate-the-efficacy-and-safety-of-oral-acetyl-l-carnitine-for-the-treatment-of-chemotherapy-induced-peripheral-neuropathy
#1
Yuanjue Sun, Yongqian Shu, Baorui Liu, Ping Liu, Changping Wu, Rongsheng Zheng, Xiaohua Zhang, Zhixiang Zhuang, Yongchuan Deng, Leizhen Zheng, Qing Xu, Bin Jiang, Xuenong Ouyang, Jianfei Gao, Nong Xu, Xiaoyi Li, Su Jiang, Chaofan Liang, Yang Yao
The present study aimed to evaluate the efficacy and safety of acetyl-L-carnitine (ALC) for the treatment of chemotherapy-induced peripheral neuropathy (CIPN). The study was carried out as a prospective, randomized, double-blind, placebo-controlled and paralleled clinical study. A total of 239 patients with CIPN were selected as the study subjects. Of the 239 subjects, 118 subjects received 3 g/day ALC orally for 8 weeks and 121 received a placebo. The primary endpoint was improvement of peripheral neuropathy by at least one grade...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28098976/adsorption-neutralization-model-and-floc-growth-kinetics-properties-of-aluminum-coagulants-based-on-sips-and-boltzmann-equation
#2
Zhen Wu, Xian Zhang, Chunjiao Zhou, Jing-Lin Pang, Panyue P Zhang
Single-molecule aluminum salt AlCl3, medium polymerized polyaluminium chloride (PAC) and high polymerized polyaluminium chloride (HPAC) were prepared in laboratory. The characteristics and coagulation properties of these prepared aluminum salts were investigated. The Langmuir, Freundlich and Sips adsorption isotherms were firstly used to describe the adsorption neutralization process in coagulation, and the Boltzmann equation was used to fit the reaction kinetics of floc growth in flocculation. It was novel to find that the experimental data fitted well with the Sips and Boltzmann equation, and the significance of parameters in the equations was discussed simultaneously...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28095118/modeling-and-optimization-of-lime-based-stabilization-in-high-alkaline-arsenic-bearing-sludges-with-a-central-composite-design
#3
Jie Lei, Bing Peng, Xiaobo Min, Yanjie Liang, Yang You, Liyuan Chai
This study focuses on the modeling and optimization of lime-based stabilization in high alkaline arsenic-bearing sludges (HAABS) and describes the relationship between the arsenic leachate concentration (ALC) and stabilization parameters to develop a prediction model for obtaining the optimal process parameters and conditions. A central composite design (CCD) along with response surface methodology (RSM) was conducted to model and investigate the stabilization process with three independent variables: the Ca/As mole ratio, reaction time and liquid/solid ratio, along with their interactions...
January 17, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28089878/pre-transplant-absolute-lymphocyte-counts-impact-the-pharmacokinetics-of-alemtuzumab
#4
Rebecca Marsh, Tsuyoshi Fukuda, Chie Emoto, Lisa Neumeier, Pooja Khandelwal, Sharat Chandra, Ashley Teusink, Alexander Vinks, Parinda A Mehta
Alemtuzumab is frequently used as part of reduced intensity conditioning (RIC) regimens for the allogeneic hematopoietic cell transplantation (HCT) of pediatric patients with non-malignant diseases. We have previously suggested an optimal Day 0 targeted range of alemtuzumab, but there are no pediatric data regarding the pharmacokinetics (PK) of subcutaneous alemtuzumab to guide precision dosing trials. The goal of this study was to prospectively characterize alemtuzumab PK and to explore absolute lymphocyte count (ALC) as a predictor of interindividual variability...
January 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28087776/seed-plant-specific-gene-lineages-involved-in-carpel-development
#5
Kai C Pfannebecker, Matthias Lange, Oliver Rupp, Annette Becker
Evolutionary innovations are important drivers of speciation and some are the defining characters of entire phyla. One such major innovation is the carpel, the unifying character and most complex plant organ, composed of many clearly distinct tissue types to ensure reproductive success. The origin of the carpel is unknown, but many components of the gene regulatory network (GRN) governing carpel development and their genetic interactions are known from the core eudicot Arabidopsis thaliana To unravel the evolution of the carpel GRN and to discriminate between "early" and "late" steps in carpel evolution we calculated thorough phylogeny reconstructions based on sequenced genomes...
January 12, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28070294/habitat-performance-relationships-of-a-large-mammal-on-a-predator-free-island-dominated-by-humans
#6
Andrew M Allen, Augusta Dorey, Jonas Malmsten, Lars Edenius, Göran Ericsson, Navinder J Singh
The demographic consequences of changes in habitat use driven by human modification of landscape, and/or changes in climate, are important for any species. We investigated habitat-performance relationships in a declining island population of a large mammal, the moose (Alces alces), in an environment that is predator-free but dominated by humans. We used a combination of demographic data, knowledge of habitat selection, and multiannual movement data of female moose (n = 17) to understand how space use patterns affect fecundity and calf survival...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28068240/does-unintentional-splenic-radiation-predict-outcomes-after-pancreatic-cancer-radiation-therapy
#7
Awalpreet S Chadha, Guan Liu, Hsiang-Chun Chen, Prajnan Das, Bruce D Minsky, Usama Mahmood, Marc E Delclos, Yelin Suh, Gabriel O Sawakuchi, Sam Beddar, Matthew H Katz, Jason B Fleming, Milind M Javle, Gauri R Varadhachary, Robert A Wolff, Christopher H Crane, Xuemei Wang, Howard Thames, Sunil Krishnan
PURPOSE: To determine whether severity of lymphopenia is dependent on radiation dose and fractional volume of spleen irradiated unintentionally during definitive chemoradiation (CRT) in patients with locally advanced pancreatic cancer (LAPC). METHODS: 177 patients with LAPC received induction chemotherapy (mainly gemcitabine-based regimens) followed by CRT (median 50.4 Gy with concurrent capecitabine) from January 2006 to December 2012. Absolute lymphocyte count (ALC) was recorded at baseline, before CRT, and 2 to 10 weeks after CRT...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28064464/ungulate-predation-and-ecological-roles-of-wolves-and-coyotes-in-eastern-north-america
#8
John F Benson, Karen M Loveless, Linda Y Rutledge, Brent R Patterson
Understanding the ecological roles of species that influence ecosystem processes is a central goal of ecology and conservation biology. Eastern coyotes (Canis latrans) have ascended to the role of apex predator across much of eastern North America since the extirpation of wolves (Canis spp.) and there has been considerable confusion regarding their ability to prey on ungulates and their ecological niche relative to wolves. Eastern wolves (C. lycaon) are thought to have been the historical top predator in eastern deciduous forests and have previously been characterized as deer specialists that are inefficient predators of moose because of their smaller size relative to gray wolves (C...
January 8, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28058678/distribution-of-rhodopin-and-spirilloxanthin-between-lh1-and-lh2-complexes-when-incorporating-carotenoid-mixture-into-the-membrane-of-purple-sulfur-bacterium-allochromatium-minutissimum-in-vitro
#9
M A Bolshakov, A A Ashikhmin, Z K Makhneva, A A Moskalenko
Carotenoid mixture enriched by rhodopin and spirilloxanthin was incorporated in LH2 and LH1 complexes from Allochromatium (Alc.) minutissimum in vitro. The maximum incorporating level was ~95%. Rhodopin (56.4%) and spirilloxanthin (13.8%) were incorporated into the LH1 complex, in contrast to the control complex, which contained primarily spirilloxanthin (66.8%). After incorporating, the LH2 complex contained rhodopin (66.7%) and didehydrorhodopin (14.6%), which was close to their content in the control (67...
November 2016: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28056941/neutrophil-lymphocyte-ratio-as-a-predictive-biomarker-for-response-to-high-dose-interleukin-2-in-patients-with-renal-cell-carcinoma
#10
James A Kuzman, David D Stenehjem, Joseph Merriman, Archana M Agarwal, Shiven B Patel, Andrew W Hahn, Anitha Alex, Dan Albertson, David M Gill, Neeraj Agarwal
BACKGROUND: Immunotherapy with high-dose interleukin-2 (HD-IL2) results in long-term survival in some metastatic renal cell carcinoma (mRCC) patients but has significant acute toxicities. Biomarkers predicting response to therapy are needed to better select patients most likely to benefit. NLR (absolute neutrophil count (ANC)/absolute lymphocyte count (ALC)) is a prognostic and predicative biomarker in various malignancies. The goal was to determine whether NLR can predict response to HD-IL2 in this setting...
January 5, 2017: BMC Urology
https://www.readbyqxmd.com/read/28035275/mobility-of-moose-comparing-the-effects-of-wolf-predation-risk-reproductive-status-and-seasonality
#11
Camilla Wikenros, Gyöngyvér Balogh, Håkan Sand, Kerry L Nicholson, Johan Månsson
In a predator-prey system, prey species may adapt to the presence of predators with behavioral changes such as increased vigilance, shifting habitats, or changes in their mobility. In North America, moose (Alces alces) have shown behavioral adaptations to presence of predators, but such antipredator behavioral responses have not yet been found in Scandinavian moose in response to the recolonization of wolves (Canis lupus). We studied travel speed and direction of movement of GPS-collared female moose (n = 26) in relation to spatiotemporal differences in wolf predation risk, reproductive status, and time of year...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28030549/prey-selection-of-scandinavian-wolves-single-large-or-several-small
#12
Håkan Sand, Ann Eklund, Barbara Zimmermann, Camilla Wikenros, Petter Wabakken
Research on large predator-prey interactions are often limited to the predators' primary prey, with the potential for prey switching in systems with multiple ungulate species rarely investigated. We evaluated wolf (Canis lupus) prey selection at two different spatial scales, i.e., inter- and intra-territorial, using data from 409 ungulate wolf-kills in an expanding wolf population in Scandinavia. This expansion includes a change from a one-prey into a two-prey system with variable densities of one large-sized ungulate; moose (Alces alces) and one small-sized ungulate; roe deer (Capreolus capreolus)...
2016: PloS One
https://www.readbyqxmd.com/read/27960177/alterations-in-fetal-leydig-cell-gene-expression-during-fetal-and-adult-development
#13
Kanako Miyabayashi, Yuichi Shima, Miki Inoue, Tetsuya Sato, Takashi Baba, Yasuyuki Ohkawa, Mikita Suyama, Ken-Ichirou Morohashi
Fetal Leydig cells (FLCs) and adult Leydig cells (ALCs) develop in the mammalian prenatal and postnatal testes, respectively. In mice, FLCs emerge in the interstitial space of the testis as early as embryonic day 12.5 and thereafter increase in number during the fetal stage. We previously established a transgenic mouse line in which FLCs are labeled with EGFP and demonstrated that the EGFP-labeled FLCs were present even in adult testes. However, the characteristics of FLCs during postnatal stages remained unclear...
December 14, 2016: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/27893758/multiple-browsers-structure-tree-recruitment-in-logged-temperate-forests
#14
Edward K Faison, Stephen DeStefano, David R Foster, Joshua M Rapp, Justin A Compton
Historical extirpations have resulted in depauperate large herbivore assemblages in many northern forests. In eastern North America, most forests are inhabited by a single wild ungulate species, white-tailed deer (Odocoileus virginianus), and relationships between deer densities and impacts on forest regeneration are correspondingly well documented. Recent recolonizations by moose (Alces americanus) in northeastern regions complicate established deer density thresholds and predictions of browsing impacts on forest dynamics because size and foraging differences between the two animals suggest a lack of functional redundancy...
2016: PloS One
https://www.readbyqxmd.com/read/27879546/early-lymphocyte-recovery-and-outcome-in-osteosarcoma
#15
Lynn Lee, Lin Fei, Jennifer Pope, Lars M Wagner
BACKGROUND: Early lymphocyte recovery following chemotherapy has been associated with improved outcome in many cancers, including in one small study of osteosarcoma patients. MATERIALS AND METHODS: To confirm this finding, we retrospectively reviewed data from 53 patients with newly diagnosed osteosarcoma who had blood counts on day 14 (±1 d) following the first cycle of cisplatin and doxorubicin. RESULTS: The median absolute lymphocyte count (ALC) 14 days after starting the first cycle of chemotherapy (ALC-14) was 1990 cells/μL (range: 600 to 6470)...
November 22, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27867830/niche-construction-social-cognition-and-language-hypothesizing-the-human-as-the-production-of-place
#16
Oliver Davies
New data is emerging from evolutionary anthropology and the neuroscience of social cognition on our species-specific hyper-cooperation (HC). This paper attempts an integration of third-person archaeological and second-person, neuroscientific perspectives on the structure of HC, through a post-Ricoeurian development in hermeneutical phenomenology. We argue for the relatively late evolution of advanced linguistic consciousness (ALC) (Hiscock in Biological Theory 9:27-41, 2014), as a reflexive system based on the 'in-between' or 'cognitive system' as reported by Vogeley et al...
2016: Culture and Brain
https://www.readbyqxmd.com/read/27864994/serum-spd-l1-upregulated-in-sepsis-may-reflect-disease-severity-and-clinical-outcomes-in-septic-patients
#17
Minlong Liu, Xiaoling Zhang, Haiyan Chen, Guoen Wang, Jun Zhang, Peng Dong, Yuanyuan Liu, Shan An, Li Wang
we aimed to find the correlation between serum sPD-L1 (soluble programmed cell death L-1 ligand) and sepsis. Totally 91 consecutive patients with sepsis were performed in a 15-bed medical intensive care unit (ICU) of the second affiliated hospital, Xi'an Jiaotong University in Xi'an, China, between February 2015 and May 2016. Healthy controls (HC) consisted of 29 healthy volunteer. Baseline demographic data were recorded. Blood samples were collected through an indwelling central venous or by peripheral venipuncture...
November 16, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27857776/maternal-bonding-styles-in-smokers-and-non-smokers-a-comparative-study
#18
Iren Csala, Monika Elemery, Fruzsina Martinovszky, Peter Dome, Balazs Dome, Gabor Faludi, Imola Sandor, Zsuzsa Gyorffy, Emma Birkas, Judit Lazary
BACKGROUND: Parental bonding has been implicated in smoking behavior, and the quality of maternal bonding (MB) has been associated with poor mental health and substance use. However, little is known about the association of MB and the smoking of the offspring. METHODS: In our study, 129 smokers and 610 non-smoker medical students completed the parental bonding instrument, which measures MB along two dimensions: care and overprotection. Four categories can be created by high and low scores on care and overprotection: optimal parenting (OP; high care/low overprotection); affectionless control (ALC; low care/high overprotection); affectionate constraint (AC; high care/high overprotection), and neglectful parenting (NP; low care/low overprotection)...
2016: Annals of General Psychiatry
https://www.readbyqxmd.com/read/27856361/reprint-of-adolescent-cortical-thickness-pre-and-post-marijuana-and-alcohol-initiation
#19
REVIEW
Joanna Jacobus, Norma Castro, Lindsay M Squeglia, M J Meloy, Ty Brumback, Marilyn A Huestis, Susan F Tapert
Cortical thickness abnormalities have been identified in youth using both alcohol and marijuana. However, limited studies have followed individuals pre- and post initiation of alcohol and marijuana use to help identify to what extent discrepancies in structural brain integrity are pre-existing or substance-related. Adolescents (N=69) were followed from ages 13 (pre-initiation of substance use, baseline) to ages 19 (post-initiation, follow-up). Three subgroups were identified, participants that initiated alcohol use (ALC, n=23, >20 alcohol use episodes), those that initiated both alcohol and marijuana use (ALC+MJ, n=23, >50 marijuana use episodes) and individuals that did not initiate either substance regularly by follow-up (CON, n=23, <3 alcohol use episodes, no marijuana use episodes)...
November 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27815773/the-neural-correlates-of-priming-emotion-and-reward-systems-for-conflict-processing-in-alcoholics
#20
T Schulte, Y-C Jung, E V Sullivan, A Pfefferbaum, M Serventi, E M Müller-Oehring
Emotional dysregulation in alcoholism (ALC) may result from disturbed inhibitory mechanisms. We therefore tested emotion and alcohol cue reactivity and inhibitory processes using negative priming. To test the neural correlates of cue reactivity and negative priming, 26 ALC and 26 age-matched controls underwent functional MRI performing a Stroop color match-to-sample task. In cue reactivity trials, task-irrelevant emotion and alcohol-related pictures were interspersed between color samples and color words. In negative priming trials, pictures primed the semantic content of an alcohol or emotion Stroop word...
November 4, 2016: Brain Imaging and Behavior
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