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https://www.readbyqxmd.com/read/28639416/persistently-low-lymphocyte-counts-after-fcr-therapy-for-chronic-lymphocytic-leukemia-are-associated-with-longer-overall-survival
#1
Erel Joffe, N Ariela Arad, Osnat Bairey, Riva Fineman, Rosa Ruchlemer, Naomi Rahimi-Levene, Lev Shvidel, Uri Greenbaum, Ariel Aviv, Tamar Tadmor, Andrei Braester, Neta Goldschmidt, Aaron Polliack, Yair Herishanu
Decreased absolute lymphocyte counts (ALCs) following frontline therapy for chronic lymphocytic leukemia may be associated with disease control, even in patients without evidence of minimal residual disease. We studied the prognostic significance of ALCs during the first year following treatment with fludarabine, cyclophosphamide, and rituximab (FCR). We evaluated 99 patients who achieved a partial response without lymphocytosis (<4.0 × 10(3) cells/μL) or better after FCR. Absolute lymphocyte counts were recorded at 3-, 6-, 9-, and 12-month posttreatment and correlated with overall survival (OS) and event-free survival (EFS)...
June 22, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28635522/dietary-intake-among-opioid-and-alcohol-using-pregnant-women
#2
Shikhar Shrestha, Elizabeth Jimenez, Laura Garrison, Peter Pribis, Dennis W Raisch, Julia M Stephen, Ludmila N Bakhireva
BACKGROUND: Substance abuse in nonpregnant adults has been associated with increased intake in calories and decreased intake of nutrient-dense foods; however, studies examining dietary intake in opioid-using and alcohol-using pregnant women are lacking. OBJECTIVE: The objective of this study was to evaluate dietary intake in opioid-using pregnant women with or without concurrent light-to-moderate alcohol use as compared to abstaining controls. METHODS: This prospective birth cohort included 102 pregnant women classified into four study groups: controls (n = 27), medication-assisted treatment (MAT; n = 26), alcohol (ALC; n = 22), and concurrent use of both substances (MAT + ALC; n = 27)...
February 22, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28626203/rheological-approach-for-determining-yield-stresses-in-flowable-resin-composites-prior-to-setting
#3
Masaki Asakura, Tatsuhide Hayashi, Shozo Tsuruta, Mitsunori Yamamoto, Shuichiro Kobayashi, Akimichi Mieki, Tatsushi Kawai
The purpose of this study is to develop a method for quantifying the fluidity of flowable resin composites using determinations of yield stress. Five commercially available composites (AliteFlo LV, Flow-it ALC, Venus flow, Tetric N-flow, Revolution Formula2) were investigated. Yield stress values were obtained by plotting shear stresses for a range of shear rates, followed by fitting of Casson fluid models to flow curve data and extrapolation to the stress axis. To confirm that yield stress reflected fluidity, apparent viscosity at the lower shear rate (0...
June 15, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28622306/changes-in-uninvolved-immunoglobulins-during-induction-therapy-for-newly-diagnosed-multiple-myeloma
#4
P Ravi, S Kumar, W Gonsalves, F Buadi, M Q Lacy, R S Go, A Dispenzieri, P Kapoor, J A Lust, D Dingli, Y Lin, S J Russell, N Leung, M A Gertz, R A Kyle, P L Bergsagel, S V Rajkumar
Little is known about the impact of multiple myeloma (MM) treatment on uninvolved immunoglobulins (Ig). We identified 448 patients who received high-dose dexamethasone (HD-DEX), lenalidomide and dexamethasone (RD), bortezomib and dexamethasone (VD), bortezomib, cyclophosphamide and dexamethasone (VCD) or bortezomib, lenalidomide and dexamethasone (VRD) for newly diagnosed MM at our institution between 2000 and 2013, and who had available data on absolute lymphocyte count (ALC) and quantitative uninvolved Ig at baseline and at the end of four cycles of therapy...
June 16, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28619108/scavenging-on-a-pulsed-resource-quality-matters-for-corvids-but-density-for-mammals
#5
Gjermund Gomo, Jenny Mattisson, Bjørn Roar Hagen, Pål Fossland Moa, Tomas Willebrand
BACKGROUND: Human food subsidies can provide predictable food sources in large quantities for wildlife species worldwide. In the boreal forest of Fennoscandia, gut piles from moose (Alces alces) harvest provide a potentially important food source for a range of opportunistically scavenging predators. Increased populations of predators can negatively affect threatened or important game species. As a response to this, restrictions on field dressing of moose are under consideration in parts of Norway...
June 15, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28611976/a-sustained-partnership-between-a-haitian-children-s-hospital-and-north-american-academic-medical-centers
#6
Michael P Koster, Jackson H Williams, Jacqueline Gautier, Renee Alce, Bernard E Trappey
Global health initiatives from academic medical centers have rapidly proliferated over the last decade. This paper endeavors to describe our 5-year experience as an academic medical collaborative supporting healthcare delivery, medical training, and research at Hôpital Saint Damien-Nos Petits Frères et Soeurs, the only freestanding children's hospital in Haiti. Descriptions of the history and current activities of our academic medical collaborative, its partnership and communication structure, its evolution to fill the expressed needs of our host site, its funding mechanisms, and its challenges and opportunities for the future are included...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28590420/anti-inflammatory-and-antioxidant-properties-of-peptides-released-from-%C3%AE-lactoglobulin-by-high-hydrostatic-pressure-assisted-enzymatic-hydrolysis
#7
Fatemeh Bamdad, Seonghee Bark, Chul Hee Kwon, Joo-Won Suh, Hoon Sunwoo
BACKGROUND: β-lactoglobulin hydrolysates (BLGH) have shown antioxidant, antihypertensive, antimicrobial, and opioid activity. In the current study, an innovative combination of high hydrostatic pressure and enzymatic hydrolysis (HHP-EH) was used to increase the yield of short bioactive peptides, and evaluate the anti-inflammatory and antioxidant properties of the BLGH produced by the HHP-EH process. METHOD: BLG was enzymatically hydrolyzed by different proteases at an enzyme-to-substrate ratio of 1:100 under HHP (100 MPa) and compared with hydrolysates obtained under atmospheric pressure (AP-EH at 0...
June 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28584067/crispr-cas9-targeted-mutagenesis-leads-to-simultaneous-modification-of-different-homoeologous-gene-copies-in-polyploid-oilseed-rape-brassica-napus
#8
Janina Braatz, Hans-Joachim Harloff, Martin Mascher, Nils Stein, Axel Himmelbach, Christian Jung
In polyploid species, altering a trait by random mutagenesis is highly inefficient due to gene redundancy. We have stably transformed tetraploid oilseed rape (Brassica napus) with a CRISPR-Cas9 construct targeting two ALCATRAZ (ALC) homoeologs. ALC is involved in valve margin development and, thus, contributes to seed shattering from mature fruits. Knocking out ALC would increase shatter resistance to avoid seed loss during mechanical harvest. We obtained a transgenic T1 plant with four alc mutant alleles by the use of a single target sequence...
June 2017: Plant Physiology
https://www.readbyqxmd.com/read/28583580/acetyl-l-carnitine-enhances-myelination-of-regenerated-fibers-of-the-lateral-olfactory-tract
#9
Nanae Fukushima, Kumiko Yokouchi, Masafumi Kuroiwa, Kyutaro Kawagishi, Tetsuji Moriizumi
It is well known that acetyl-l-carnitine (ALC) has various neuroprotective effects against neurodegenerative diseases. In addition, it has been reported that ALC facilitates myelination of regenerated axons after peripheral nerve injuries. We previously reported that spontaneous regeneration of the lateral olfactory tract (LOT), the main fiber tract of the central olfactory system, consistently occurred in newborn rats and a majority of these regenerated fibers were unmyelinated in neonatally LOT-transected young adult rats...
June 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28576564/cognitive-deficits-induced-by-combined-exposure-of-stress-and-alcohol-mediated-through-oxidative-stress-parp-pathway-in-the-hippocampus
#10
Rajat Pant, Ashok Jangra, Mohit Kwatra, Tavleen Singh, Pawan Kushwah, Babul Kumar Bezbaruah, Satendra Singh Gurjar, Swopna Phukan
Several studies reported that stress can enhance the consumption of alcohol in humans and animals. However, the combinatorial effect of stress and alcohol on cognitive function and neurochemical alterations is quite understudied. In the present study, we have elucidated the involvement of oxidative stress-PARP cascade in alcohol and restraint stress (RS)-exposed animals using a PARP inhibitor, 1,5-isoquinolinediol (3mg/kg for 14days). Male Swiss albino mice were given alcohol (ALC) or RS (2h per day) or both in ALC+RS group for 28days...
May 30, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28575974/construction-of-biodegradable-and-biocompatible-aie-active-fluorescent-polymeric-nanoparticles-by-ce-iv-hno3-redox-polymerization-in-aqueous-solution
#11
Shengxian Yu, Dazhuang Xu, Qing Wan, Meiying Liu, Jianwen Tian, Qiang Huang, Fengjie Deng, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Aggregation-induced emission (AIE) active fluorescence polymeric nanoparticles (FPNs) have recently received increasing interests for biomedical applications such as cell imaging, drug delivery, disease diagnosis and treatment. Fabricated strategies of AIE-active FPNs with high efficiency, simplification and tenderness are still passionately pursued to promote the development of theranostic systems. In this work, we develop a facile method for the preparation of AIE-active FPNs by adopting Ce(IV)/HNO3 redox polymerization under near room temperature...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28558844/radiation-related-lymphopenia-is-associated-with-spleen-irradiation-dose-during-radiotherapy-in-patients-with-hepatocellular-carcinoma
#12
Jing Liu, Qianqian Zhao, Weiye Deng, Jie Lu, Xiaoqing Xu, Renben Wang, Xia Li, Jinbo Yue
BACKGROUND: The decrease in peripheral blood lymphocytes induced by radiation lessens the antitumour effect of the immune response, which might cause immunosuppression. We aimed to investigate the correlation between the decrease in peripheral blood lymphocytes during radiotherapy (RT) and the spleen irradiation dose in patients with hepatocellular carcinoma (HCC). METHODS: The subjects were 59 patients with HCC who had received RT from 2005 to 2014. The Min ALC (minimum value of absolute counts for peripheral blood lymphocytes) was collected from the routine workup for each patient prior to RT and weekly during RT...
May 30, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28555486/topically-administered-acetyl-l-carnitine-increases-sciatic-nerve-regeneration-and-improves-functional-recovery-after-tubulization-of-transected-short-nerve-gaps
#13
Rahim Mohammadi, Keyvan Amini
BACKGROUND: Peripheral nerve injuries repair is still among the most challenging and concern-raising tasks in neurosurgery. The effect of an acetyl-L-carnitin-loaded silicone tube as an in-situ delivery system in defects bridging was studied using a rat sciatic nerve regeneration model. METHODS: A 10-mm sciatic nerve defect was bridged using a silicone tube (SIL/ALC) filled with 10 µL acetyl-L-carnitine (100 ng/mL). In the control group (SIL), the tube was filled with the same volume of the phosphate-buffered solution...
August 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28554151/executive-functions-in-alcohol-dependence-a-theoretically-grounded-and-integrative-exploration
#14
Mélanie Brion, Fabien D'Hondt, Anne-Lise Pitel, Benoît Lecomte, Marc Ferauge, Philippe de Timary, Pierre Maurage
BACKGROUND: Alcohol-dependence is related to large-scale cognitive impairments, particularly for executive functions (EF). These deficits persist even after long-term abstinence and have a major impact on patients' everyday life and relapse risk. Earlier studies, based on multi-determined tasks, mostly focused on inhibition and did not offer a theoretically-grounded and exhaustive view of the differential deficit across EF. The present paper proposes a model-based exploration of EF in alcohol-dependent individuals (ALC), to precisely compare the specific deficit related to each executive subcomponent...
May 19, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28553857/the-position-of-the-mental-foramen-in-dentate-and-edentulous-mandibles-clinical-and-surgical-relevance
#15
Antonios Charalampakis, Georgios Kourkoumelis, Christina Psari, Vassilios Antoniou, Maria Piagkou, Theano Demesticha, Evangelos Kotsiomitis, Theodore Troupis
BACKGROUND: The knowledge of the exact location of the mental foramen (MF) in dentate and edentulous mandibles is clinically important when constructing complete dentures, performing anaesthetic block of the lower-anterior teeth area and intervening in the MF nearby area. In edentulous mandibles, the bone resorption after teeth loss makes the mental nerve (MN) prone to damage due to the extreme location of the MF very close to the alveolar crest (AC). Chronic compression on the MN may result in pain in the area of MN distribution (ipsilateral face and cheek area) and numbness at the lower lip...
May 29, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28553235/4-phenylbutyrate-mitigates-fluoride-induced-cytotoxicity-in-alc-cells
#16
Maiko Suzuki, Eric T Everett, Gary M Whitford, John D Bartlett
Chronic fluoride over-exposure during pre-eruptive enamel development can cause dental fluorosis. Severe dental fluorosis is characterized by porous, soft enamel that is vulnerable to erosion and decay. The prevalence of dental fluorosis among the population in the USA, India and China is increasing. Other than avoiding excessive intake, treatments to prevent dental fluorosis remain unknown. We previously reported that high-dose fluoride induces endoplasmic reticulum (ER) stress and oxidative stress in ameloblasts...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28536866/a-placebo-controlled-study-of-quetiapine-xr-in-bipolar-depression-accompanied-by-generalized-anxiety-with-and-without-a-recent-history-of-alcohol-and-cannabis-use
#17
Keming Gao, Stephen J Ganocy, Carla Conroy, Brittany Brownrigg, Mary Beth Serrano, Joseph R Calabrese
OBJECTIVE: This study aims to compare treatment response in bipolar I or II depression and generalized anxiety disorder (GAD) with and without recent alcohol and/or cannabis use disorder (ALC/CAN) to quetiapine-XR (extended release) or placebo. METHODS: A randomized, double-blind, 8-week study of quetiapine-XR versus placebo in patients with bipolar I or II depression and GAD with or without a recent ALC/CAN was used to compare changes in Hamilton Depression Rating Scale-17, Hamilton Anxiety Rating Scale, the 16-item Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR-16), Clinical Global Impression for Bipolar Disorder-Severity (CGI-BP-S), and Timeline Follow Back within and between groups...
May 24, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28534301/effects-of-acetyl-l-carnitine-in-diabetic-neuropathy-and-other-geriatric-disorders
#18
REVIEW
G Sergi, S Pizzato, F Piovesan, C Trevisan, N Veronese, E Manzato
A long history of diabetes mellitus and increasing age are associated with the onset of diabetic neuropathy, a painful and highly disabling complication with a prevalence peaking at 50% among elderly diabetic patients. Acetyl-L-carnitine (ALC) is a molecule derived from the acetylation of carnitine in the mitochondria that has an essential role in energy production. It has recently been proposed as a therapy to improve the symptoms of diabetic neuropathy. ALC is widely distributed in mammalian tissues, including the brain, blood-brain barrier, brain neurons, and astrocytes...
May 22, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28505173/continental-divide-predicting-climate-mediated-fragmentation-and-biodiversity-loss-in-the-boreal-forest
#19
Dennis L Murray, Michael J L Peers, Yasmine N Majchrzak, Morgan Wehtje, Catarina Ferreira, Rob S A Pickles, Jeffrey R Row, Daniel H Thornton
Climate change threatens natural landscapes through shifting distribution and abundance of species and attendant change in the structure and function of ecosystems. However, it remains unclear how climate-mediated variation in species' environmental niche space may lead to large-scale fragmentation of species distributions, altered meta-population dynamics and gene flow, and disrupted ecosystem integrity. Such change may be especially relevant when species distributions are restricted either spatially or to a narrow environmental niche, or when environments are rapidly changing...
2017: PloS One
https://www.readbyqxmd.com/read/28488930/preparation-of-liposome-bearing-disulfide-proteinoid-and-its-reduction-responsive-release-property
#20
Kyeongnan Kwon, Jin-Chul Kim
Egg phosphatidylcholine (Egg PC) liposome bearing a disulfide proteinoid exhibited a reduction-responsive release property. Proteinoid composed of Asp, Leu, and cystamine (Prot(ALC)) and Asp and Leu (Prot(AL)) were synthesized by thermal condensation, confirmed by Raman, FT-IR, (1)H NMR and (13)C NMR spectroscopy. Egg PC liposome bearing the proteinoid was prepared by a film hydration and sonication method. The fluorescence quenching of dye (i.e. calcein) loaded in liposome bearing the proteinoid was 68.1-78...
May 18, 2017: Journal of Biomaterials Science. Polymer Edition
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