Read by QxMD icon Read

triplet therapie

Zafar Mahmood, Jianzhang Zhao
Fluorescent molecular probes based on photo-induced electron transfer (PET) are well-known for which fluorescence is efficiently tuned OFF/ON by a PET process. Now we demonstrate that the triplet excited state of the probes is unable to be quenched by PET, which is in stark contrast to the singlet excited state (fluorescence). This conclusion was proved by the preparation of a fluorescent molecular probe BDP-DPA, which shows enhanced fluorescence upon addition of a Zn(ii) salt. With fluorescence spectroscopy, nanosecond transient absorption spectroscopy and electrochemical studies, we found that the triplet excited state of BDP-DPA was not quenched by any PET process, although the singlet excited state (fluorescence) of BDP-DPA was quenched...
September 29, 2016: Photochemical & Photobiological Sciences
Michele M Kim, Rozhin Penjweini, Xing Liang, Timothy C Zhu
Photodynamic therapy (PDT) is an effective non-ionizing treatment modality that is currently being used for various malignant and non-malignant diseases. In type II PDT with photosensitizers such as benzoporphyrin monoacid ring A (BPD), cell death is based on the creation of singlet oxygen ((1)O2). With a previously proposed empirical five-parameter macroscopic model, the threshold dose of singlet oxygen ([(1)O2]rx,sh]) to cause tissue necrosis in tumors treated with PDT was determined along with a range of the magnitude of the relevant photochemical parameters: the photochemical oxygen consumption rate per light fluence rate and photosensitizer concentration (ξ), the probability ratio of (1)O2 to react with ground state photosensitizer compared to a cellular target (σ), the ratio of the monomolecular decay rate of the triplet state photosensitizer (β), the low photosensitizer concentration correction factor (δ), and the macroscopic maximum oxygen supply rate (g)...
September 23, 2016: Journal of Photochemistry and Photobiology. B, Biology
Chengzhe Wang, Levi Lystrom, Huimin Yin, Marc Hetu, Svetlana Kilina, Sherri A McFarland, Wenfang Sun
The synthesis, photophysics, reverse saturable absorption, and photodynamic therapeutic effect of six cationic biscyclometalated Ir(iii) complexes (1-6) with extended π-conjugation on the diimine ligand and/or the cyclometalating ligands are reported in this paper. All complexes possess ligand-localized (1)π,π* absorption bands below 400 nm and charge-transfer absorption bands above 400 nm. They are all emissive in the 500-800 nm range in deoxygenated solutions at room temperature. All complexes exhibit strong and broad triplet excited-state absorption at 430-800 nm, and thus strong reverse saturable absorption for ns laser pulses at 532 nm...
October 18, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
D Nguyen, D H Thomas, M Cao, D O'Connor, J M Lamb, K Sheng
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
David O Oluwole, Earl Prinsloo, Tebello Nyokong
Zinc monocarboxyphenoxy phthalocyanine (ZnMCPPc) was linked to human serum albumin (HSA) and chitosan via amide bond formation. The photophysical behavior and photodynamic therapy (PDT) activity (against human breast adenocarcinoma cell line (MCF-7 cells) of ZnMCPPc alone and its conjugates were investigated. The conjugates showed improved fluorescence, triplet and singlet oxygen quantum yields when compared to ZnMCPPc alone. The in vitro dark cytotoxicity and PDT studies were carried out at a dose of 3.6μg/mL to 57...
September 20, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Maria Gavriatopoulou, Evangelos Terpos, Efstathios Kastritis, Meletios A Dimopoulos
INTRODUCTION: Renal impairment (RI) is one of the most common complication of multiple myeloma (MM). RI is present in almost 20% of MM patients at diagnosis and in 40%-50% of patients during the course of their disease. AREAS COVERED: Biology along with tools for diagnosis and management of RI are reported in this paper. Papers published in PubMed and reported abstracts up to May 2016 were used. EXPERT OPINION: Moderate and severe RI increases the risk of early death; thus rapid intervention and initiation of anti-myeloma treatment is essential and improves renal outcomes in RI patients...
September 27, 2016: Expert Opinion on Pharmacotherapy
Monica Neagu, Carolina Constantin, Mircea Tampa, Clara Matei, Andreea Lupu, Emilia Manole, Rodica-Mariana Ion, Concettina Fenga, Aristidis M Tsatsakis
Metallo-phthalocyanines due to their photophysical characteristics as high yield of triplet state and long lifetimes, appear to be good candidates for photodynamic therapy (PDT). Complexes with diamagnetic metals such as Zn2+, Al3+ Ga3+ and In3+meet such requirements and are recognized as potential PDT agents. Clinically, Photofrin® PDT in neuroblastoma therapy proved in pediatric subjects diagnosed with progressive/recurrent malignant brain tumors increased progression free survival and overall survival outcome...
September 10, 2016: Oncotarget
Binod Dhakal, Saulius Girnius, Parameswaran Hari
There have been major recent advancements in the understanding and management of multiple myeloma. Diagnostic criteria have been revised and former ultra-high-risk smoldering multiple myeloma is now considered multiple myeloma in need of treatment. Understanding clonal progression, evolution, and tides not only has helped elucidate the disease behavior but might help expand therapeutic choices in order to select appropriate treatment for patients. Unprecedented response rates with modern triplet induction therapies containing proteasome inhibitor and immunomodulators have made this approach standard for initial treatment...
2016: F1000Research
S N Letuta, S N Pashkevich, A T Ishemgulov, Yu D Lantukh, E K Alidzhanov, S S Sokabaeva, V V Bryukhanov
The features of delayed fluorescence (DF) and phosphorescence in erythrosine stained healthy and cancer-diseased mammary gland tissues of BYRB-line mice were investigated in vitro. Thermoactivated delayed fluorescence (TDF), triplet-triplet annihilation (TTA) and originated from singlet-triplet annihilation (STA) delayed fluorescence are investigated as competing channels of radiative relaxation of the triplet states of erythrosine. The dominant role of diffusive-mobile molecular oxygen in deactivation of triplet-excited long-live states of the dye molecules in cells is determined...
October 2016: Journal of Photochemistry and Photobiology. B, Biology
Walter Duco, Viviana Grosso, Daniel Zaccari, Arnaldo T Soltermann
The thermal decomposition of 9,10 diphenylanthracene peroxide (DPAO2) generates DPA and a mix of triplet and singlet molecular oxygen. For DPAO2 the efficiency to produce singlet molecular oxygen is 0.35. On the other hand, it has shown that many thermal reactions can be carried out through the interaction of molecules with ultrasound. Ultrasound irradiation can create hydrodynamic stress (sonomechanical process), inertial cavitation (pyrolitic process) and long range effects mediated by radicals or ROS. Sonochemical reactions can be originated by pyrolytic like process, shock mechanical waves, thermal reactions and radical and ROS mediated reactions...
August 16, 2016: Methods: a Companion to Methods in Enzymology
D P Ferreira, D S Conceição, R C Calhelha, T Sousa, Radu Socoteanu, I C F R Ferreira, L F Vieira Ferreira
Porphyrins and some of its derivatives are well known and widely used as photosensitizers (PSs) for Photodynamic Therapy of Cancer (PDT). The present study regards the characterization and evaluation of a synthesized asymmetric porphyrin dye in solution to be used as PS for PDT. This molecule was also incorporated into biopolymeric films composed by chitosan, polyethylene glycol (PEG) and gelatin in order to overtake some of the disadvantages inherent to the PS, but more important, to evaluate the potential of a system composed by the porphyrin/biopolymer to be applied as localized therapeutic agents...
October 20, 2016: Carbohydrate Polymers
Koushambi Mitra, Srishti Gautam, Paturu Kondaiah, Akhil R Chakravarty
Platinum(II) complexes of the type [Pt(L)(cat)] (1 and 2), in which H2 cat is catechol and L represents two 2-(2-pyridyl)benzimidazole ligands with 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) pendants, were synthesized to achieve mitochondria-targeted photocytotoxicity. The complexes showed strong absorptions in the range λ=510-540 nm. Complex 1 exhibited intense emission at λ=525 nm in 1 % DMSO/water solution (fluorescence quantum yield of 0.06). Nanosecond transient absorption spectral features indicated an enhanced population of the triplet excited state in di-iodinated complex 2...
September 6, 2016: ChemMedChem
Christian Reichardt, Tariq Sainuddin, Maria Wächtler, Susan Monro, Stephan Kupfer, Julien Guthmuller, Stefanie Gräfe, Sherri McFarland, Benjamin Dietzek
The influence of ligand protonation on the photophysics of a ruthenium (Ru) dyad bearing the 2-(1-pyrenyl)-1H-imidazo[4,5-f][1,10]-phenanthroline (ippy) ligand was investigated by time-resolved transient absorption spectroscopy. It was found that changes in the protonation state of the imidazole group led to changes in the electronic configuration of the lowest lying excited state. Formation of the fully deprotonated imidazole anion resulted in excited state signatures that were consistent with a low-lying intraligand (IL) triplet state...
August 18, 2016: Journal of Physical Chemistry. A
Yandun Zou, Xiaoyan Ma, Haiying Yu, Chunling Hu, Limei Fan, Xuehong Ran
PURPOSE: The use of carfilzomib/pomalidomide single-agent or in combination with other agents in patients with refractory/relapsed multiple myeloma (RRMM) was not clearly clarified in clinical practice. We sought to compile the available clinical reports to better understand the efficacy and safety of carfilzomib (CFZ) and pomalidomide (POM). RESULTS: Based on our research criteria, we identified 37 prospective studies that evaluated 1160 patients. Analysis of subgroup differences between carfilzomib single-agent and CFZ/DEX dual combination showed significantly(P < 0...
July 21, 2016: Oncotarget
Shuming Bai, Mario Barbatti
Recent experiments replacing oxygen atoms by sulfur in thymine have revealed that absorption and intersystem crossing properties of these derivatives are strongly dependent on the position and number of the substitutions, affecting their potential performance for photodynamical therapy. Using multireference quantum chemical methods (CASPT2 and DFT/MRCI), we calculated absorption spectra and spin-orbit coupling matrix elements for thymine (Thy), 2-thiothymine (2tThy), 4-thiothymine (4tThy), and 2,4-dithiothymine (2,4dtThy), to investigate this relation between structure and photophysics...
August 18, 2016: Journal of Physical Chemistry. A
Rozhin Penjweini, Michele M Kim, Jarod C Finlay, Timothy C Zhu
Type II photodynamic therapy (PDT) is used for cancer treatment based on the combined action of a photosensitizer, a special wavelength of light, oxygen ((3)O2) and generation of singlet oxygen ((1)O2). Intra-patient and inter-patient variability of oxygen concentration ([(3)O2]) before and after the treatment as well as photosensitizer concentration and hemodynamic parameters such as blood flow during PDT has been reported. Simulation of these variations is valuable, as it would be a means for the rapid assessment of treatment effect...
February 13, 2016: Proceedings of SPIE
Xiaoqun Liu, Xiangdong Liu, Tiankui Qiao, Wei Chen, Sujuan Yuan
BACKGROUND: The combined therapy of bevacizumab (BEV) with taxane (paclitaxel or docetaxel) has shown an improvement on progression-free survival (PFS) and objective remission in Her2-negative patients with locally recurrent or metastatic breast cancer (LR/MBC). However, there was no benefit in overall survival (OS). The aim of this study was to evaluate the efficacy and safety of adding an agent to the BEV/taxane regimens for the treatment of Her2-negative patients with LR/MBC in a first-line setting...
2016: OncoTargets and Therapy
Md M Alam, F Bolze, C Daniel, L Flamigni, C Gourlaouen, V Heitz, S Jenni, J Schmitt, A Sour, B Ventura
A complete one- and two-photon spectroscopic and photophysical characterization of three diketopyrrolopyrrole (DPP)-porphyrin conjugates is reported. The increased conjugation introduced by the incremental addition of one, two and four DPP units on the meso porphyrin positions strongly affects the optical properties of the systems. Ground and triplet excited state absorption spectra show a gradual broadening and bathochromic shift and a trend to lower energies is also observed for both fluorescence and phosphorescence emission...
August 21, 2016: Physical Chemistry Chemical Physics: PCCP
Artemis Papanastasiou, Gerasimos Konstantinou, Themistocles Vlachos
We present a case of folie à trois with schizoaffective and negative symptoms in monozygotic triplets, which to our knowledge is unique. For 4 years starting in their late teens, the 3 male siblings withdrew socially, adopted a primitive lifestyle, and exhibited poor self-care with increasing aggression, which led to their admission to the hospital at the age of 22 years. Over the subsequent 8 years, 1 brother recovered fully with treatment, resumed academic and social functioning, and does not need medication therapy currently...
July 2016: Journal of Psychiatric Practice
Abraham B Alemayehu, Nicholas U Day, Tomoyasu Mani, Alexander B Rudine, Kolle E Thomas, Odrun A Gederaas, Sergei A Vinogradov, Carl C Wamser, Abhik Ghosh
Two amphiphilic corroles-5,10,15-tris(3-carboxyphenyl)corrole (H3[mTCPC]) and 5,10,15-tris(4-carboxyphenyl)corrole (H3[pTCPC])-and their gold complexes have been synthesized, and their photophysical properties and photovoltaic behavior have been investigated. Like other nonpolar gold corroles, Au[mTCPC] and Au[pTCPC] were both found to exhibit room temperature phosphorescence in deoxygenated solutions with quantum yields of ∼0.3% and triplet lifetimes of ∼75 μs. Both compounds exhibited significant activity as dyes in photodynamic therapy experiments and in dye-sensitized solar cells...
July 27, 2016: ACS Applied Materials & Interfaces
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"