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https://www.readbyqxmd.com/read/29906570/randomized-placebo-controlled-phase-iii-trial-of-fosaprepitant-ondansetron-dexamethasone-fond-versus-fond-plus-olanzapine-fond-o-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting-in-patients-with-hematologic-malignancies-receiving-highly-emetogenic
#1
Amber B Clemmons, Julianne Orr, Benjamin Andrick, Arpita Gandhi, Claude Sportes, David DeRemer
Evidence supports olanzapine for prophylaxis of chemotherapy-induced nausea/vomiting (CINV) for highly emetogenic chemotherapy (HEC); however, most studies focus on solid malignancies and single day regimens. A randomized, double-blinded, placebo-controlled trial was conducted to compare addition of olanzapine to triplet therapy (fosaprepitant, ondansetron, dexamethasone; FOND-O) versus triplet therapy alone (FOND) in preventing CINV in hematology patients receiving single and multi-day HEC and hematopoietic cell transplant (HCT) regimens (NCT02635984)...
June 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29886081/gastric-cancer-french-intergroup-clinical-practice-guidelines-for-diagnosis-treatments-and-follow-up-snfge-ffcd-gercor-unicancer-sfcd-sfed-sfro
#2
REVIEW
Aziz Zaanan, Olivier Bouché, Leonor Benhaim, Bruno Buecher, Nicolas Chapelle, Olivier Dubreuil, Nadim Fares, Victoire Granger, Christine Lefort, Johan Gagniere, Julie Meilleroux, Anne-Sophie Baumann, Veronique Vendrely, Michel Ducreux, Pierre Michel
INTRODUCTION: This document is a summary of the French Intergroup guidelines regarding the management of gastric cancer published in October 2016, available on the website of the French Society of Gastroenterology (SNFGE) (www.tncd.org), updated in October 2017. METHODS: This collaborative work was realized under the auspices of several French medical societies involved in management of gastric cancer. Recommendations are graded in three categories (A-C), according to the amount of evidence found in the literature until July 2017...
June 6, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29880892/patient-centered-practice-in-elderly-myeloma-patients-an-overview-and-consensus-from-the-european-myeloma-network-emn
#3
REVIEW
Alessandra Larocca, Sandra Maria Dold, Sonja Zweegman, Evangelos Terpos, Ralph Wäsch, Mattia D'Agostino, Sophia Scheubeck, Hartmut Goldschmidt, Francesca Gay, Michele Cavo, Heinz Ludwig, Christian Straka, Sara Bringhen, Holger W Auner, Jo Caers, Martin Gramatzki, Massimo Offidani, Meletios A Dimopoulos, Hermann Einsele, Mario Boccadoro, Pieter Sonneveld, Monika Engelhardt
Multiple myeloma is a disease typical of the elderly, and, because of the increase in life expectancy of the general population, its incidence is expected to grow in the future. Elderly patients represent a particular challenge due to their marked heterogeneity. Many new and highly effective drugs have been introduced in the last few years and results from clinical trials are promising. Besides the availability of novel agents, a careful evaluation of elderly patients showed to be a key factor for the success of therapy...
April 25, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29870908/photophysicochemical-properties-and-photodynamic-therapy-activity-of-highly-water-soluble-zn-ii-phthalocyanines
#4
David O Oluwole, Fatma Aslıhan Sarı, Earl Prinsloo, Edith Dube, Abdulcelil Yuzer, Tebello Nyokong, Mine Ince
The syntheses of two zinc(II) phthalocyanines (ZnPcs) having either imidazole (ZnPc 1) or pyridiloxy (ZnPc 2) moieties as their macrocycle substituents are reported. Quaternization of the ZnPcs with methyl iodide afforded water soluble cationic phthalocyanines. The photophysical, photochemical properties and photodynamic therapy (PDT) activity of the ZnPcs were studied in solution. The fluorescence quantum yield and lifetime of ZnPc 1 were higher as compared to ZnPc 2. ZnPc 2 afforded higher triplet state (ΦT ) and singlet oxygen quantum yields (ΦΔ ) in comparison to ZnPc 1...
May 29, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29870907/a-theoretical-study-of-a-series-of-water-soluble-triphenylamine-photosensitizers-for-two-photon-photodynamic-therapy
#5
Xin Wang, Xue Yin, Xiao-Yong Lai, Ying-Tao Liu
In this study, the therapeutic activity of a series of water-soluble triphenylamine (TP) photosensitizers (Ps) was explored by using theoretical simulations. The key photophysical parameters which determined the efficiency of Ps, such as absorption electronic spectra, singlet-triplet energy gaps and spin-orbit matrix elements were calculated at density functional theory and its time-dependent extension (DFT, TD-DFT). The calculated results showed that these TP photosensitizers possessed large two-photon absorption cross-section in the near-infrared region (NIR), efficient intersystem crossing (ISC) transition from the first singlet excited state to the low lying triplet excited states and sufficient energy for generating reactive oxygen species (ROS)...
May 28, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29862592/rational-design-of-conjugated-photosensitizers-with-controllable-photoconversion-for-dually-cooperative-phototherapy
#6
Shuyue Ye, Jiaming Rao, Shihong Qiu, Jinglong Zhao, Hui He, Ziling Yan, Tao Yang, Yibin Deng, Hengte Ke, Hong Yang, Yuliang Zhao, Zhengqing Guo, Huabing Chen
High-performance photosensitizers are highly desired for achieving selective tumor photoablation in the field of precise cancer therapy. However, photosensitizers frequently suffer from limited tumor suppression or unavoidable tumor regrowth due to the presence of residual tumor cells surviving in phototherapy. A major challenge still remains in exploring an efficient approach to promote dramatic photoconversions of photosensitizers for maximizing the anticancer efficiency. Here, a rational design of boron dipyrromethene (BDP)-based conjugated photosensitizers (CPs) that can induce dually cooperative phototherapy upon light exposure is demonstrated...
June 3, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29860172/glycosylated-zinc-phthalocyanine-gold-nanoparticle-conjugates-for-photodynamic-therapy-effect-of-nanoparticle-shape
#7
Edith Dube, David O Oluwole, Njemuwa Nwaji, Tebello Nyokong
In this work, we report on the synthesis of tris-[(2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-yl)methoxy)-2-(4-benzo[d]thiazol-2-ylphenoxyphthalocyaninato] zinc(II) (complex 3) and its linkage to gold nanoparticles (AuNPs) of different shapes through S-Au/N-Au self-assembly. The conjugates of complex 3 (with both gold nanorods (AuNR) and nanospheres (AuNS)), displayed decreased fluorescence quantum yield with corresponding improved triplet and singlet quantum yields compared to complex 3 alone, however 3-AuNR showed improved properties than 3-AuNS...
May 28, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29844008/heterogeneity-of-second-line-treatment-for-patients-with-multiple-myeloma-in-the-connect-mm-registry-2010-2016
#8
Sundar Jagannath, Rafat Abonour, Brian G M Durie, Cristina Gasparetto, James W Hardin, Mohit Narang, Howard R Terebelo, Kathleen Toomey, Lynne Wagner, Shankar Srinivasan, Amani Kitali, Lihua Yue, E Dawn Flick, Amit Agarwal, Robert M Rifkin
BACKGROUND: The treatment landscape for multiple myeloma (MM) has undergone recent changes with the regulatory approval of several new therapies indicated for second- and later-line disease. Using data from Connect MM, the largest multisite, primarily community-based, prospective, observational registry of MM patients in the United States, selection of second-line treatments was evaluated during a 5-year period from 2010 to 2016. PATIENTS AND METHODS: Eligible patients were aged ≥ 18 years, had newly diagnosed MM ≤ 2 months before study entry, and were followed for up to 8 years...
May 4, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29806867/a-cyclometalated-ir-iii-complex-as-lysosome-targeted-photodynamic-therapeutic-agent-for-integrated-imaging-and-therapy-in-cancer-cells
#9
Karivachery V Sudheesh, Prasad S Jayaram, Animesh Samanta, Kochan S Bejoymohandas, Ramapurath S Jayasree, Ayyappanpillai Ajayaghosh
Organelle targeted photosensitizers (PSs) having luminescence properties are potential theranostic agents for simultaneous luminescence imaging and photodynamic therapy. Herein, we report a water soluble luminescent cyclometalated Ir(III) complex, Ir-Bp-Ly as lysosome targeted theranostic probe. Ir-Bp-Ly exhibits exceptional photophysical properties of good triplet state quantum yield (0.90), singlet oxygen generation quantum yield (0.71 at pH 4) and long life time (1.47µs). Interestingly, Ir-Bp-Ly localized mostly in the lysosome because of the presence of morpholine units, suggesting its potential as a lyso-tracker...
May 28, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29804905/tucatinib-with-capecitabine-and-trastuzumab-in-advanced-her2-positive-metastatic-breast-cancer-with-and-without-brain-metastases-a-non-randomised-open-label-phase-1b-study
#10
Rashmi Murthy, Virginia F Borges, Alison Conlin, Jorge Chaves, Marc Chamberlain, Todd Gray, Alex Vo, Erika Hamilton
BACKGROUND: Tucatinib is a potent and selective oral HER2 tyrosine kinase inhibitor, with the potential to provide a well tolerated new treatment option for patients whose disease has progressed on currently available therapies. We aimed to determine the recommended phase 2 dose, safety, pharmacokinetics, and preliminary activity of tucatinib in combination with capecitabine or trastuzumab in patients with HER2-positive breast cancer with or without brain metastases. METHODS: In this non-randomised, open-label, phase 1b trial done in five sites in the USA, we recruited patients aged 18 years or older with HER2-positive progressive breast cancer who had been previously treated with trastuzumab, pertuzumab, and trastuzumab emtansine...
May 24, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29784738/optimizing-adjuvant-therapy-for-localized-colon-cancer-and-treatment-selection-in-advanced-colorectal-cancer
#11
Axel Grothey, Alan P Venook
Results from the pivotal IDEA trial, which evaluated 3 versus 6 months of adjuvant oxaliplatin-based chemotherapy, are incorporated into the NCCN Guidelines for Colon Cancer. The guidelines recommend that for patients with low-risk stage III disease, the preferred regimen is CAPEOX for 3 months or FOLFOX for 3 to 6 months. For patients with high-risk stage III disease, the preferred regimen is CAPEOX for 3 to 6 months or FOLFOX for 6 months. In metastatic disease, tumor sidedness should be a consideration when choosing a biologic...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29768064/a-look-at-treatment-strategies-for-relapsed-multiple-myeloma
#12
Giusy Cetani, Mario Boccadoro, Stefania Oliva
Multiple myeloma treatment considerably improved during the past decade, thanks to novel effective drugs, a better understanding of myeloma biology and clonal heterogeneity, and an improved management of toxicities. The choice of regimen at relapse is usually based on prior response, toxicities, age and comorbidities of relapsed patients. Areas covered: A review was performed of the most recent and effective therapeutic strategies for the relapsed myeloma setting, by documenting the latest clinical evidence from phase II and III clinical trials...
May 24, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29744791/olanzapine-as-antiemetic-drug-in-oncology-a-retrospective-study-in-non-responders-to-standard-antiemetic-therapy
#13
Florian Slimano, Florence Netzer, Isabelle Borget, François Lemare, Benjamin Besse
Background The role of olanzapine in the treatment of chemotherapy-induced nausea and vomiting (CINV) in addition to the antiemetic therapeutic combination with aprepitant, setrons, and corticosteroids has not been well defined. Objective To investigate the effectiveness of the addition of olanzapine to a standard triplet therapy for the prevention of CINV in patients who experienced CINV during their first chemotherapy course, despite receiving a well-managed prevention protocol. Setting One comprehensive cancer centre in France...
May 9, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29741409/healthcare-resource-utilization-with-ixazomib-or-placebo-plus-lenalidomide-dexamethasone-in-the-randomized-double-blind-phase-3-tourmaline-mm1-study-in-relapsed-refractory-multiple-myeloma
#14
Parameswaran Hari, Huamao Mark Lin, Yanyan Zhu, Deborah Berg, Paul G Richardson, Philippe Moreau
AIMS: The aim of this analysis was to assess healthcare resource utilization in the pivotal phase 3 TOURMALINE-MM1 study of the oral proteasome inhibitor ixazomib or placebo plus lenalidomide and dexamethasone (Rd) in relapsed and/or refractory multiple myeloma (RRMM). METHODS: In this double-blind, placebo-controlled, randomized study (NCT01564537), 722 patients with RRMM following 1-3 prior lines of therapy received Rd plus ixazomib (ixazomib-Rd; N = 360) or matching placebo (placebo-Rd; N = 362) until disease progression or unacceptable toxicity...
May 9, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29721163/a-phase-ii-trial-of-1st-line-modified-folfoxiri-plus-bevacizumab-treatment-for-metastatic-colorectal-cancer-harboring-ras-mutation-jaccro-cc-11
#15
Hironaga Satake, Yu Sunakawa, Yuji Miyamoto, Masato Nakamura, Hiroshi Nakayama, Manabu Shiozawa, Akitaka Makiyama, Kazuma Kobayashi, Yutaro Kubota, Misuzu Mori, Masahito Kotaka, Akinori Takagane, Masahiro Gotoh, Masahiro Takeuchi, Masashi Fujii, Wararu Ichikawa, Takashi Sekikawa
FOLFOXIRI plus bevacizumab is considered a standard initial therapy for metastatic colorectal cancer (mCRC). However, few prospective trials have evaluated triplet therapy plus bevacizumab in patients with RAS mutant mCRC. Patients with an age of 20 to 75 years, and unresectable, measurable tumors harboring RAS mutation were given first-line treatment with bevacizumab (5 mg/kg on day 1) plus modified-FOLFOXIRI (irinotecan 150 mg/m2 , oxaliplatin 85 mg/m2 , levofolinate 200 mg/m2 , and fluorouracil 2400 mg/m2 as a 46-h continuous infusion on day 1, repeated every 2 weeks)...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29720731/front-line-therapies-for-elderly-patients-with-transplant-ineligible-multiple-myeloma-and-high-risk-cytogenetics-in-the-era-of-novel-agents
#16
REVIEW
Herve Avet-Loiseau, Thierry Facon
In multiple myeloma, certain cytogenetic abnormalities, such as t(4;14), t(14;16), and del(17p), are considered high risk and are associated with worse prognosis. Patients with these high-risk cytogenetic abnormalities, as well as those who are elderly and transplant ineligible, have not experienced the same degree of improved survival outcomes that other patients have seen with recent advances in the treatment of multiple myeloma. To date, no treatment regimen has demonstrated sustained and consistent survival benefits in elderly, transplant-ineligible patients with high-risk cytogenetic abnormalities and newly diagnosed multiple myeloma...
March 28, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29693683/recent-progress-in-heavy-atom-free-organic-compounds-showing-unexpected-intersystem-crossing-isc-ability
#17
REVIEW
Jianzhang Zhao, Kepeng Chen, Yuqi Hou, Yuanyuan Che, Lang Liu, Dianzeng Jia
In this review, recent progress in heavy atom-free triplet photosensitizers was summarized. The general approaches include attaining S1/Tn states sharing similar energy levels or proper molecular geometry to satisfy the angular momentum reservation in intersystem crossing (ISC). ISC via the higher singlet excited state (Sn, n > 1) → Tm (m > 1), which is a rarely reported phenomenon, was also discussed. The ISC of some Bodipy dimers was proposed to be via the 'doubly excited state', but recent studies show that the ISC mechanism of these Bodipy dimers is charge separation/recombination...
May 23, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29674402/cutaneous-lymphangitis-carcinomatosa-made-cervicofacial-oedema-intractable-in-a-patient-with-superior-vena-cava-syndrome
#18
Eriko Kashihara, Osamu Kanai, Misato Okamura, Tadashi Mio
Cutaneous lymphangitis carcinomatosa (CLC) is a rare form of cutaneous metastasis that causes lymphoedema and various eruptions. We report a case of lung cancer with CLC that caused both superior vena cava (SVC) stenosis and cervicofacial oedema, suggestive of SVC syndrome. A 64-year-old woman with lung adenocarcinoma presented with cervicofacial oedema and erythema, followed by severe dyspnoea 2 months after four cycles of carboplatin, pemetrexed and bevacizumab triplet therapy. Although chest CT indicated SVC stenosis, cervicofacial oedema remained despite treating the SVC stenosis via balloon dilation...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29666724/in-vitro-fertilization-using-luteinizing-hormone-releasing-hormone-injections-resulted-in-healthy-triplets-without-increased-attack-rates-in-a-hereditary-angioedema-case
#19
Ceyda Tunakan Dalgıç, Fatma Düşünür Günsen, Gökten Bulut, Emine Nihal Mete Gökmen, Aytül Zerrin Sin
Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The management of pregnant patients with C1-INH-HAE is a challenge for the physician. Intravenous plasma-derived nanofiltered C1-INH (pdC1INH) is the only recommended option throughout pregnancy, postpartum, and breastfeeding period. In order to increase pregnancy rates, physicians use fertilization therapies increasing endogen levels of estrogens. Therefore, these techniques can provoke an increase in the number and severity of edema attacks in C1-INH-HAE...
2018: Case Reports in Immunology
https://www.readbyqxmd.com/read/29650906/-a-case-of-stage-iv-gastric-cancer-curative-resection-by-conversion-therapy
#20
Hitoya Sano, Kazuya Yamaguchi, Toshiyuki Tanahashi, Takuji Sakuratani, Ryutaro Mori, Satoshi Matsui, Hisashi Imai, Yoshihiro Tanaka, Nobuhisa Matsuhashi, Takao Takahashi, Shinji Osada, Kazuhiro Yoshida
We experienced a case of curative resection as a multidisciplinary treatment for unresectable gastric cancer that attributed to peritoneal disseminations and direct invasion to other organs.Two courses of triplet chemotherapy(DCS therapy)were performed under enteral stent placement and nasoenteral nutrition for direct infiltration into the transverse colon with entire circumference stenosis.Distal gastrectomy and right hemicolectomy were performed as conversion therapy, and R0 resection was achieved.After the operation, S-1 as adjuvant chemotherapy was performed and there has been no relapse survival for 13 months since the operation...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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