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anemia aplasic

J O Bay, A Cabrespine, C Faucher, R Tabrizi, P Bordigoni, A Berceanu, V Coiteux, M Renaud, V Mialou, M Robin, M Kuentz, P Chevallier, N Dhédin, A Huynh, F Garban, F Witz, A Buzyn, T De Revel, C Galambrun, E Deconinck, N Contentin, S François, N Gratecos, D Blaise, M Michallet
The purpose of this paper is to describe the outcome of patients who underwent double allogeneic hematopoietic stem cell transplantation (AHSCT) with reduced-intensity conditioning regimens (RIC). Forty-five patients who received double RIC-AHSCT between 1997 and 2006 were retrospectively studied. The predominant diagnosis was acute myeloid leukemia (AML) (n = 17). Other diagnoses were aplasic anemia (AA) (n = 5), myelodysplasic disorder (n = 5), acute lymphoblastic leukemia (ALL) (n = 4), chronic myelomonocytic leukemia (CML) (n = 3), myeloma (n = 3), non-Hodgkin lymphoma (NHL) (n = 3), chronic lymphocytic leukemia (CLL) (n = 2), Hodgkin's disease (HD) (n = 2), and chronic myelomonocytic leukemia (n = 1)...
February 2012: Biology of Blood and Marrow Transplantation
Reuven Or, Memet Aker, Michael Yechiel Shapira, Igor Resnick, Menachem Bitan, Simcha Samuel, Shimon Slavin
Our understanding of the pathophysiology of hematopoietic failure associated syndromes led to the developmental of potentially curative procedures for the treatment of many diseases including Severe aplastic anemia, Fanconi's anemia, Primary immunodeficiency, Osteopetrosis, and Metabolic diseases. Although the number of patients that were transplanted for bone marrow deficiency diseases is relatively low as compared to patients with hematological malignancies, the impact on the knowledge of hematopoiesis and transplantation biology is tremendous...
November 2004: Springer Seminars in Immunopathology
P Simon
As other Renal Replacement therapies, peritoneal dialysis has to control the morbid events due to severe uremia and to prevent new pathology due to long term dialysis. This review concerns major studies published in literature during the last ten years. Critical analysis has permitted to define the benefits and the disadvantages of this treatment method. When a patient has a residual diuresis, peritoneal dialysis is efficient: 1) to control cardio-vascular events due to chronic renal failure, 2) to remove beta 2-microglobulin, 3) to improve anemia due to uremia without using recombinant human erythropoietin, 4) to reduce the risk of developing aplasic bone by using a dialysate calcium concentration of 2...
1995: Néphrologie
G Schaison
The occurrence of a transitory aplasia followed shortly thereafter by an acute leukemia in a known sequence in children is rare. We report 13 observations involving children between 6 months and 10 years of age. Splenomegaly was observed in 5 patients and hepatomegaly in two. There was a tricytopenia in 5 cases, bicytopenia in 4 and an isolated cytopenia in the remaining 4 cases. The phase of aplasia was short, lasting from 6 to 30 days. Complete bone marrow recovery occurred with integral restitution. Remission was spontaneous or followed transfusion or corticosteroid therapy and lasted for 2 to 6 months...
March 1982: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
N E Kay, M M Oken, J Ascensao, M E Kaplan
The peripheral blood T cells of a hypertransfused patient with B-chronic lymphocytic leukemia and pure red cell aplasic were found to exhibit unusual spontaneous cytotoxic activity in vitro. The patient's E-rosette positive cells were cytotoxic for K562 (cultured human erythroleukemia cells) and allogeneic B and T lymphocytes freshly isolated from the peripheral blood of normal and CLL donors. They failed to kill autologous B cells, erythroid progenitors present in allogeneic bone marrow, and a number of cultured human tumor cells (Malme, CAKI) even after prolonged (36 h) co-culture...
1985: Leukemia Research
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