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https://www.readbyqxmd.com/read/29675680/a-randomized-double-blind-phase-2-study-of-ruxolitinib-or-placebo-in-combination-with-capecitabine-in-patients-with-advanced-her2-negative-breast-cancer-and-elevated-c-reactive-protein-a-marker-of-systemic-inflammation
#1
Joyce O'Shaughnessy, Angela DeMichele, Cynthia X Ma, Paul Richards, Denise A Yardley, Gail Shaw Wright, Kevin Kalinsky, Ronald Steis, Sami Diab, Gerard Kennealey, Ryan Geschwindt, Wei Jiang, Hope S Rugo
PURPOSE: The Janus-associated kinase (JAK)/signal transducer and activator of transcription pathway is a key regulator of inflammatory signaling, associated with tumorigenesis, cell survival, and progression. This randomized phase 2 trial evaluated the efficacy and safety of the addition of ruxolitinib, a JAK1/JAK2 inhibitor, to capecitabine in patients with HER2-negative advanced breast cancer and high systemic inflammation (modified Glasgow Prognostic Score [mGPS] ≥ 1). METHODS: Patients with ≤ 2 prior chemotherapy regimens for advanced or metastatic disease or hormone receptor-positive patients with disease progression on prior hormonal therapies were randomized 1:1 to 21-day cycles of ruxolitinib (n = 76) or placebo (n = 73) plus capecitabine...
April 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29672815/minimally-invasive-isolated-tricuspid-valve-redo-surgery-a-safety-and-outcome-analysis
#2
Gloria Färber, Sophie Tkebuchava, Rodolfo Siordia Dawson, Hristo Kirov, Mahmoud Diab, Peter Schlattmann, Torsten Doenst
BACKGROUND:  Isolated tricuspid valve (TV) surgery is considered a high risk-procedure. The optimal surgical approach is controversial. We analyzed our experience with isolated TV redo surgery performed either minimally invasively (redo-MITS) or through sternotomy. METHODS:  We retrospectively analyzed all patients with previous cardiac surgery who underwent redo-MITS ( n  = 26) and compared them to redo-Sternotomy ( n  = 17). A group of primary-MITS ( n  = 61) served as control...
April 19, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29670715/the-effect-of-surface-topographical-changes-of-two-different-surface-treatments-rotary-instrument
#3
Nashwan-Ahmed Qaed, Bilal-Diab Mourshed, Hashem-Motahir Al-Shamiri, Nader Alaizari, Saleh-Sulaiman Alhamdah
Background: One of the major innovations in endodontics has been the introduction of nickel-titanium (NiTi) alloy. This study evaluated the surface topographical changes of two different surface treatments rotary instrument after instrumentation and sterilization. Material and Methods: 240 Extracted teeth were included in this study. 90 new AlphaKite and Revo-S NiTi rotary instruments were selected and divided into two groups (Group A 45 AlphaKite and group B 45 Revo-S)...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29665199/authorship-in-reports-of-clinical-practice-guidelines-a-systematic-cross-sectional-analysis
#4
Mohamed Nomier, Assem M Khamis, Ahmed Ali, Karim N Daou, Aline T Semaan, Maya Diab, Elie A Akl
BACKGROUND: A transparent and explicit reporting on authors' contributions to the development of clinical practice guidelines and on panelists' characteristics is essential for their credibility and trustworthiness. We did not find published studies on authorship or panel involvement in clinical practice guidelines. OBJECTIVE: To describe the approach to authorship in reports of clinical practice guidelines, and the characteristics of individual authors. METHODS: We conducted a cross-sectional survey of guidelines listed in the National Guideline Clearing House (NGC) in 2016...
April 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29628414/catheter-related-venous-thrombosis-in-hospitalized-pediatric-patients-with-inflammatory-bowel-disease-incidence-characteristics-and-role-of-anticoagulant-thromboprophylaxis-with-enoxaparin
#5
Carrie E Diamond, Carole Hennessey, Jennifer Meldau, Christine J Guelcher, Michael F Guerrera, Laurie S Conklin, Karun V Sharma, Yaser A Diab
OBJECTIVE: To describe the incidence and characteristics of central venous catheter (CVC)-related thrombosis in hospitalized pediatric patients with active inflammatory bowel disease (IBD) and report the potential usefulness of anticoagulant thromboprophylaxis (AT). STUDY DESIGN: We conducted a retrospective study of patients who were admitted to our children's hospital in the last 2 years with active IBD and required a CVC and identified all patients with an objectively confirmed symptomatic CVC-related thrombosis...
April 5, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29621966/the-epidemiology-of-urinary-tract-infections-in-hiv-positive-patients-at-a-tertiary-care-university-hospital-in-central-europe-2011-2016
#6
Romana Klasinc, Armin Rieger, Elisabeth Presterl, Thomas Wrba, Magda Diab-Elschahawi
OBJECTIVES: There is limited published data concerning recent epidemiology of urinary tract infections (UTI) in HIV-patients, thus we analysed independent risk factors for UTI in HIV positive individuals and antimicrobial resistance rates of E. coli to antimicrobial agents commonly used in UTI. To determine the prevalence of symptomatic urinary tract infections (UTI) in HIV-patients we performed a retrospective case-control study. METHODS: We included 313 HIV-patients, 101 with UTI and 212 age and gender matched controls, attending the HIV outpatient clinic at the Vienna University hospital (VUH) over a period from January 2011 to September 2016...
April 5, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29615264/extended-spectrum-beta-lactamase-esbl-and-carbapenemase-producing-enterobacteriaceae-in-water-sources-in-lebanon
#7
Mohamad Diab, Monzer Hamze, Richard Bonnet, Estelle Saras, Jean-Yves Madec, Marisa Haenni
Extended-spectrum beta-lactamases (ESBLs) have been recurrently reported in both human and veterinary medicine, and carbapenemases have also emerged in these two sectors. Such resistance phenotypes were increasingly reported in the environment, which both receives and further disseminates multidrug-resistant (MDR) bacteria. Here, we report the high contamination of water samples (68.2%; 15/22) collected in estuaries in Lebanon. From these 15 contaminated sites, a total of 21 ESBL-producing (mostly harbouring the blaCTX-M-15 gene) and four carbapenemase-producing (two blaOXA-48 and two blaOXA-244 ) Enterobacteriaceae were recovered...
April 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29610425/vitamin-excess-and-deficiency
#8
Liliane Diab, Nancy F Krebs
The published literature supports the high prevalence of supplement use in children and adolescents in the United States. Pediatricians today are faced with questions from parents and patients about the benefits, safety, efficacy, and correct dose of vitamins and minerals. In this article, we review 7 vitamins with the most clinical relevance as judged by abundance in food, risks and symptoms of deficiency, and potential for toxicity. Specifically, we focus on possible clinical scenarios that can be indicative of nutritional deficiency...
April 2018: Pediatrics in Review
https://www.readbyqxmd.com/read/29607229/a-case-of-levamisole-induced-agranulocytosis
#9
Thamer Kassim, Lakshmi Chintalacheruvu, Osman Bhatty, Mohammad Selim, Osama Diab, Ali Nayfeh, Jayadev Manikkam Umakanthan, Maryam Gbadamosi-Akindele
A sixty-eight-year-old male with a past medical history of recurrent cocaine use presented to the emergency department with recurrent diarrhea and was found to have a white blood cell (WBC) count of 1.9 × 109 /L with agranulocytosis (absolute neutrophil count (ANC) of 95 cell/mm3 ). At admission, the patient disclosed that he used cocaine earlier during the day, and a urine drug screen tested positive for this. On hospital day one, the patient was found to have a fever with a maximum temperature of 313...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29577003/emergency-repair-of-a-perforated-mycotic-aneurysm-with-a-self-made-pericardial-tube-graft
#10
Nawras Diab, Clarence Pingpoh, Matthias Siepe, Friedhelm Beyersdorf, Ahmed Kharabish, Martin Czerny
A 63-year-old female with a history of kidney transplantation was admitted for emergency repair of a perforated mycotic aneurysm of the right subclavian artery (RSA) in combination with a paravertebral and posterior mediastinal abscess. After resection of the aneurysm and after radical local debridement, orthotopic repair was performed with a self-made pericardial tube graft from the brachiocephalic bifurcation to the thoracic outlet. The paravertebral and posterior mediastinal abscess was drained. The postoperative course was uneventful...
January 2018: Thoracic and Cardiovascular Surgeon Reports
https://www.readbyqxmd.com/read/29576820/the-emergency-department-crash-cart-a-systematic-review-and-suggested-contents
#11
REVIEW
Gabrielle A Jacquet, Bachar Hamade, Karim A Diab, Rasha Sawaya, Gilbert Abou Dagher, Eveline Hitti, Jamil D Bayram
BACKGROUND: As the field of Emergency Medicine grows worldwide, the importance of an Emergency Department Crash Cart (EDCC) has long been recognized. Yet, there is paucity of relevant peer-reviewed literature specifically discussing EDCCs or proposing detailed features for an EDCC suitable for both adult and pediatric patients. METHODS: The authors performed a systematic review of EDCC-specific literature indexed in Pubmed and Embase on December 20, 2016. In addition, the authors reviewed the 2015 American Heart Association (AHA) guidelines for cardiopulmonary resuscitation and emergency cardiovascular care, the 2015 European Resuscitation Council (ERC) guidelines for resuscitation, and the 2013 American College of Surgeons (ACS) Advanced Trauma Life Support (ATLS) 9th edition...
2018: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29575972/express-pulmonary-arterial-hypertension-and-atrial-arrhythmias-incidence-risk-factors-and-clinical-impact
#12
Valentina Mercurio, Grace Peloquin, Khalil I Bourji, Nermin Diab, Takahiro Sato, Blessing Enobun, Traci Housten Harris, Rachel Damico, Todd M Kolb, Stephen C Mathai, Ryan J Tedford, Carlo Gabriele Tocchetti, Paul Hassoun
No abstract text is available yet for this article.
January 1, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29565950/pulsed-radiofrequency-treatment-for-chronic-post-surgical-orchialgia-a-double-blind-sham-controlled-randomized-trial-three-month-results
#13
Diab Fuad Hetta, Ali Mohammed Mahran, Emad Eldien Kamal
BACKGROUND: Chronic post-surgical pain in the groin region represents a challenge for the managing physician and is a burden on the quality of life of the patient. None of the existing interventions or medical treatment is satisfactory. OBJECTIVES: We aim to evaluate the analgesic efficacy of pulsed radiofrequency (PRF) applied to the ilioinguinal nerve and the genital branch of the genitofemoral nerve for patients suffering from chronic post-surgical orchialgia...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29561607/cyclic-distannene-or-bis-stannylene-with-a-ferrocenyl-backbone-synthesis-structure-and-coordination-chemistry
#14
Jessica Henoch, Armin Auch, Fatima Diab, Klaus Eichele, Hartmut Schubert, Peter Sirsch, Theresa Block, Rainer Pöttgen, Lars Wesemann
1,1'-Dilithioferrocene was reacted with 2 equiv of isopropyl (Ar*) or methyl (Ar') substituted terphenyl tin(II) chloride. Reaction product 1, carrying the bulkier terphenyl substituent Ar*, displays a bis(stannylene) structure in the solid state without formation of a tin-tin bond. Temperature-dependent solution119 Sn NMR spectroscopy, however, revealed a dynamic interplay between bis(stannylene) (100 °C) and cyclic distannene (-80 °C). In contrast to 1, the less bulky Ar' substituent results in a cyclic distannene 2...
March 21, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29553438/the-protective-role-of-maternal-post-traumatic-growth-and-cognitive-trauma-processing-in-palestinian-mothers-and-infants-a-longitudinal-study
#15
Safwat Y Diab, Sanna Isosävi, Samir R Qouta, Saija Kuittinen, Raija-Leena Punamäki
BACKGROUND: Women at pre partum and post partum are especially susceptible to war trauma because they struggle to protect their infants from danger. Trauma research suggests increased problems in maternal mental health and infant development. Yet many cognitive-emotional processes affect the trauma survivors' mental health, such as post-traumatic growth and post-traumatic cognition. The aim of this study was to examine whether a mother's high post-traumatic growth and optimal post-traumatic cognition could protect their own mental health and their infant's stress regulation from the effects of traumatic war experiences...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29553425/integrating-a-public-health-and-human-rights-approach-into-mental-health-services-for-palestinians-in-the-gaza-strip
#16
Marwan Diab, Yasser Abu Jamei, Ashraf Kagee, Guido Veronese
BACKGROUND: In the context of violations of human rights and insecurity, the Gaza Community Mental Health Programme (GCMHP) provides mental health services and psychosocial interventions that match local cultural and social norms. The GCMHP uses a community mental health approach to promote the psychological wellbeing of the people living in the Gaza Strip and advocate on mental health issues. METHODS: The GCMHP provides preventive and therapeutic care to a broad public health spectrum of Gazan society...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29544544/comparative-and-molecular-analysis-of-mrsa-isolates-from-infection-sites-and-carrier-colonization-sites
#17
Khaled R Alkharsah, Suriya Rehman, Fatimah Alkhamis, Amani Alnimr, Asim Diab, Amein K Al-Ali
BACKGROUND: Methicillin resistant Staphylococcus aureus (MRSA) constitutes a major global health concern causing hospital and community acquired infections. A wide diversity of MRSA genotypes are circulating in geographically related regions. Therefore understanding the molecular epidemiology of MRSA is fundamental to design control and clearance measures. METHODS: A total of 106 MRSA isolates from infection (51) and carrier colonization sites (55) are characterized genetically based on SCCmec and MLST genotyping methods in addition to detection of PVL, TSST-1 and enterotoxins...
March 15, 2018: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29535125/a-phase-i-clinical-trial-of-azd1775-in-combination-with-neoadjuvant-weekly-docetaxel-and-cisplatin-before-definitive-therapy-in-head-and-neck-squamous-cell-carcinoma
#18
Eduardo Méndez, Cristina P Rodriguez, Micheal Kao, Sharat C Raju, Ahmed Diab, Richard A Harbison, Eric Q Konnick, Ganesh Mugundu, Rafael Santana-Davila, Renato Martins, Neal D Futran, Laura Q M Chow
PURPOSE: The WEE1 tyrosine kinase regulates G2/M transition and maintains genomic stability, particularly in p53-deficient tumors which require DNA repair after genotoxic therapy. There is a need to exploit the role of WEE1 inhibition in head and neck squamous cell carcinoma (HNSCC) mostly driven by tumor-suppressor loss. This completed phase I clinical trial represents the first published clinical experience using the WEE1 inhibitor, AZD1775, with cisplatin and docetaxel. EXPERIMENTAL DESIGN: We implemented an open-label phase I clinical trial using a 3+3 dose-escalation design for patients with Stage III/IVB HNSCC with borderline-resectable or unresectable disease, who were candidates for definitive chemoradiation...
March 13, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29527858/ethnicity-of-symptomatic-coronary-artery-disease-referred-for-coronary-angiography-in-the-galilee-prevalence-risk-factors-and-a-case-for-screening-and-modification
#19
Nizar Andria, Ali Nassar, Fabio Kusniec, Diab Ghanim, Dahud Qarawani, Erez Kachel, Khaled Taha, Offer Amir, Shemy Carasso
BACKGROUND: Coronary artery disease (CAD) has known risk factors. Individual risks related to specific ethnicities are complex and depend on genetic predisposition and lifestyle. OBJECTIVES: To compare the nature and prevalence of risk factors in Arab and non-Arab ethnic patients with symptomatic obstructive CAD referred for coronary angiography. METHODS: CAD, defined as coronary angiography with a ≥ 50% narrowing in ≥ 1 vessel, was diagnosed in 1029 patients admitted to a medical center between April 2014 and October 2015...
March 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29526448/s-aureus-endocarditis-clinical-aspects-and-experimental-approaches
#20
REVIEW
V Hoerr, M Franz, M W Pletz, M Diab, S Niemann, C Faber, T Doenst, P C Schulze, S Deinhardt-Emmer, B Löffler
Infective endocarditis (IE) is a life-threatening disease, caused by septic vegetations and inflammatory foci on the surface of the endothelium and the valves. Due to its complex and often indecisive presentation the mortality rate is still about 30%. Most frequently bacterial microorganisms entering the bloodstream are the underlying origin of the intracardiac infection. While the disease was primarily restricted to younger patients suffering from rheumatic heart streptococci infections, new at risk categories for Staphylococcus (S...
February 21, 2018: International Journal of Medical Microbiology: IJMM
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