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https://www.readbyqxmd.com/read/29457270/clinical-and-echocardiographic-characteristics-of-patients-in-sinus-rhythm-normal-left-ventricular-function-and-indeterminate-diastolic-function
#1
Matan Shimron, Lynne Williams, Yevgeni Hazanov, Diab Ghanim, Wadia Kinany, Offer Amir, Shemy Carasso
BACKGROUND: Diastolic dysfunction (DDFx) is the major underlying mechanism of heart failure with preserved left ventricular ejection fraction (EF). Yet, the echocardiographic diagnosis of DDFx in patients in sinus rhythm is challenging and up to 25% of studies have discrepant measures making assessment of DDFx indeterminate. We aimed to describe the clinical and echocardiographic characteristics of patients with indeterminate diastolic function compared to patients with definite normal and abnormal diastolic function...
February 19, 2018: Echocardiography
https://www.readbyqxmd.com/read/29455003/combinatorial-strategy-of-epigenetic-and-hormonal-therapies-a-novel-promising-approach-for-treating-advanced-prostate-cancer
#2
Tarek K Motawi, Hebatallah A Darwish, Iman Diab, Maged W Helmy, Mohamed Noureldin
AIMS: Estrogens act as key factors in prostate biology, cellular proliferation and differentiation as well as cancer development and progression. The expression of estrogen receptor (ER)-β appears to be lost during prostate cancer progression through hypermethylation mechanism. Epigenetic drugs such as 5-aza-2'-deoxycytidine (5-AZAC) and Trichostatin A (TSA) showed efficacy in restoring ERβ expression in prostate cancer cells. This study was designed to explore the potential anti-carcinogenic effects resulting from re-expressing ERβ1 using 5-AZAC and/or TSA, followed by its stimulation with Diarylpropionitrile (DPN), a selective ERβ1 agonist, in prostate cancer cell line PC-3...
February 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29433571/granulomatous-sarcoid-like-lesions-associated-with-checkpoint-inhibitors-a-marker-of-therapy-response-in-a-subset-of-melanoma-patients
#3
Michael T Tetzlaff, Kelly C Nelson, Adi Diab, Gregg A Staerkel, Priyadharsini Nagarajan, Carlos A Torres-Cabala, Beth A Chasen, Jennifer A Wargo, Victor G Prieto, Rodabe N Amaria, Jonathan L Curry
BACKGROUND: Immune checkpoint therapy has dramatically changed the landscape of cancer therapy, providing an efficacious and durable therapeutic option for patients with advanced-stage disease. However, dermatologic toxicities are a well-recognized side effect in patients receiving this therapy. A spectrum of immune related adverse events (irAEs) involving the skin can occur and include immunobullous disorders, lichenoid dermatitis, and vitiligo. Granulomatous/sarcoid-like lesions are now being recognized with the current class of checkpoint inhibitors (CPIs) that involve the dermis, the subcutaneous tissue (panniculitis), and lymph nodes...
February 12, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29421995/new-drugs-therapeutic-strategies-and-future-direction-for-the-treatment-of-pulmonary-arterial-hypertension
#4
Valentina Mercurio, Anna Bianco, Giacomo Campi, Alessandra Cuomo, Nermin Diab, Angela Mancini, Paolo Parrella, Mario Petretta, Paul Hassoun, Domenico Bonaduce
Despite recent advances in pulmonary arterial hypertension (PAH) treatment, this condition is still characterized by an extremely poor prognosis. In this review, we discuss the use of newly-approved drugs for PAH treatment with already known mechanisms of action (macitentan), innovative targets (riociguat and selexipag), and novel therapeutic approaches with initial up-front combination therapy. Secondly, we describe new potential signalling pathways and investigational drugs with promising role in the treatment of PAH...
January 31, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29413737/ethnic-variation-in-satisfaction-and-appearance-concerns-in-adolescents-with-idiopathic-scoliosis-undergoing-posterior-spinal-fusion-with-instrumentation
#5
Alexander A Theologis, Matthew Crawford, Mohammad Diab
STUDY DESIGN: Cohort analysis. OBJECTIVE: Document satisfaction with management and appearance concerns in children of different ethnicity who underwent spinal fusion/instrumentation for adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: Scoliosis Research Society Questionnaire (SRS-30) outcomes in AIS indicate a link between appearance and satisfaction as well as ethnic variation in appearance domain. Exploration of these findings in the Scoliosis Appearance Questionnaire (SAQ) will allow better understanding of ethnic variation in appearance concerns...
March 2018: Spine Deformity
https://www.readbyqxmd.com/read/29404806/first-line-ribociclib-plus-letrozole-in-postmenopausal-women-with-hr-%C3%A2-her2-%C3%A2-advanced-breast-cancer-tumor-response-and-pain-reduction-in-the-phase-3-monaleesa-2-trial
#6
Wolfgang Janni, Emilio Alba, Thomas Bachelot, Sami Diab, Miguel Gil-Gil, Thaddeus J Beck, Larisa Ryvo, Rafael Lopez, Michaela Tsai, Francisco J Esteva, Pilar Zamora Auñón, Zdenek Kral, Patrick Ward, Paul Richards, Timothy J Pluard, Santosh Sutradhar, Michelle Miller, Mario Campone
PURPOSE: The phase 3 MONALEESA-2 study demonstrated that addition of ribociclib (RIB) to letrozole (LET) significantly improved progression-free survival (PFS) in patients (pts) with hormone receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer (ABC). Here, we evaluated duration of response (DoR), tumor shrinkage, PFS by treatment-free interval (TFI), and health-related quality of life (HRQoL). METHODS: Postmenopausal women (N = 668) with HR+ , HER2- ABC and no prior systemic therapy for ABC were randomized to RIB (600 mg/day; 3 weeks on/1 week off) plus LET (2...
February 5, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29396581/routine-cardiac-catheterization-prior-to-fontan-operation-is-it-a-necessity
#7
Bassel Mohammad Nijres, Joshua J Murphy, Karim Diab, Sawsan Awad, Ra-Id Abdulla
Prior to the Fontan procedure, patients with single ventricle physiology with Glenn shunt are typically referred for cardiac catheterization to assess hemodynamics and potentially provide interventional measures. Currently, echocardiography provides detailed information which together with other non-invasive imaging such as CT scan and MRI may obviate the need for routine cardiac catheterization prior to the Fontan procedure. In this study, we examine the findings in cardiac catheterization in this population to determine: (a) the accuracy of echocardiography in providing adequate information prior to the Fontan procedure, particularly in identifying those in need of per-catheter intervention, and (b) the percentage of patients requiring interventional procedures during cardiac catheterization...
February 3, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29394108/participant-outcomes-from-methods-of-recruitment-for-videogame-research
#8
Courtney Ryan, Hafza Dadabhoy, Tom Baranowski
OBJECTIVE: The most productive methods of recruitment for a videogame for health (G4H) trial are not known. Success or failure of recruitment methods has been reported for a variety of clinical trials, but few specifically for G4H trials. This study's goal was to recruit 444 overweight or obese (body mass index percentile between the 84.5th-99.4th percentiles) children between the ages of 10-12 years. The article reports the results of different methods of participant recruitment. MATERIALS AND METHODS: Participants had to agree to three fasting blood samples (baseline, immediately after, and 2 months later); be willing to wear an accelerometer for 7 days at each assessment; read and speak English fluently (because the games were in English); have no history of any condition that would affect what he/she could eat or how much physical activity he/she could get; and have an eligible home computer purchased in the last 5 years with high-speed internet...
February 2018: Games for Health
https://www.readbyqxmd.com/read/29387478/retrospective-review-of-metastatic-melanoma-patients-with-leptomeningeal-disease-treated-with-intrathecal-interleukin-2
#9
Isabella C Glitza, Michelle Rohlfs, Nandita Guha-Thakurta, Roland L Bassett, Chantale Bernatchez, Adi Diab, Scott E Woodman, Cassian Yee, Rodabe N Amaria, Sapna P Patel, Hussein Tawbi, Michael Wong, Wen-Jen Hwu, Patrick Hwu, Amy Heimberger, Ian E McCutcheon, Nicholas Papadopoulos, Michael A Davies
Objectives: Metastatic melanoma patients with leptomeningeal disease (LMD) have an extremely poor prognosis, with a median survival measured in weeks, and few treatment options. Outcomes of a retrospective cohort of patients with LMD that were treated with intrathecal interleukin-2 (IT IL-2) were reviewed to assess the long-term efficacy of this therapy. Methods: The records of metastatic melanoma patients with LMD who were treated with IT IL-2 from 2006 to 2014 in a Compassionate Investigational New Drug study were reviewed...
2018: ESMO Open
https://www.readbyqxmd.com/read/29387473/humoral-and-cell-mediated-immune-responses-to-h5n1-plant-made-virus-like-particle-vaccine-are-differentially-impacted-by-alum-and-gla-se-adjuvants-in-a-phase-2-clinical-trial
#10
Stéphane Pillet, Éric Aubin, Sonia Trépanier, Jean-François Poulin, Bader Yassine-Diab, Jan Ter Meulen, Brian J Ward, Nathalie Landry
The hemagglutinination inhibition (HI) response remains the gold standard used for the licensure of influenza vaccines. However, cell-mediated immunity (CMI) deserves more attention, especially when evaluating H5N1 influenza vaccines that tend to induce poor HI response. In this study, we measured the humoral response (HI) and CMI (flow cytometry) during a Phase II dose-ranging clinical trial (NCT01991561). Subjects received two intramuscular doses, 21 days apart, of plant-derived virus-like particles (VLP) presenting the A/Indonesia/05/2005 H5N1 influenza hemagglutinin protein (H5) at the surface of the VLP (H5VLP)...
2018: NPJ Vaccines
https://www.readbyqxmd.com/read/29376844/clinico-pathologic-disparities-of-breast-cancer-in-hispanic-latina-women
#11
Z Nahleh, G Botrus, A Dwivedi, N Badri, S Otoukesh, N Diab, S Biswas, M Jennings, S Elzamly
BACKGROUND: Breast cancer is the leading cause of cancer death in Hispanic/Latina women nationwide. Limited cancer research has been conducted in this population. El Paso, Texas is a large border city with a population of around 900,000, of which 85% are Latinos and would provide a suitable setting for this study. The aim of this study is to evaluate ethnic differences and cancer characteristics in Hispanic/latina women with breast cancer. METHODS: After IRB approval, we retrospectively analyzed the variables of patients with breast cancer treated consecutively at a large tertiary medical center in El Paso, TX between 2005-2015...
January 23, 2018: Breast Disease
https://www.readbyqxmd.com/read/29370228/regional-differences-in-antihyperglycemic-medication-are-not-explained-by-individual-socioeconomic-status-regional-deprivation-and-regional-health-care-services-observational-results-from-the-german-diab-core-consortium
#12
Christina Bächle, Heiner Claessen, Werner Maier, Teresa Tamayo, Michaela Schunk, Ina-Maria Rückert-Eheberg, Rolf Holle, Christa Meisinger, Susanne Moebus, Karl-Heinz Jöckel, Sabine Schipf, Henry Völzke, Saskia Hartwig, Alexander Kluttig, Lars Kroll, Ute Linnenkamp, Andrea Icks
AIMS: This population-based study sought to extend knowledge on factors explaining regional differences in type 2 diabetes mellitus medication patterns in Germany. METHODS: Individual baseline and follow-up data from four regional population-based German cohort studies (SHIP [northeast], CARLA [east], HNR [west], KORA [south]) conducted between 1997 and 2010 were pooled and merged with both data on regional deprivation and regional health care services. To analyze regional differences in any or newer anti-hyperglycemic medication, medication prevalence ratios (PRs) were estimated using multivariable Poisson regression models with a robust error variance adjusted gradually for individual and regional variables...
2018: PloS One
https://www.readbyqxmd.com/read/29361468/neoadjuvant-plus-adjuvant-dabrafenib-and-trametinib-versus-standard-of-care-in-patients-with-high-risk-surgically-resectable-melanoma-a-single-centre-open-label-randomised-phase-2-trial
#13
Rodabe N Amaria, Peter A Prieto, Michael T Tetzlaff, Alexandre Reuben, Miles C Andrews, Merrick I Ross, Isabella C Glitza, Janice Cormier, Wen-Jen Hwu, Hussein A Tawbi, Sapna P Patel, Jeffrey E Lee, Jeffrey E Gershenwald, Christine N Spencer, Vancheswaran Gopalakrishnan, Roland Bassett, Lauren Simpson, Rosalind Mouton, Courtney W Hudgens, Li Zhao, Haifeng Zhu, Zachary A Cooper, Khalida Wani, Alexander Lazar, Patrick Hwu, Adi Diab, Michael K Wong, Jennifer L McQuade, Richard Royal, Anthony Lucci, Elizabeth M Burton, Sangeetha Reddy, Padmanee Sharma, James Allison, Phillip A Futreal, Scott E Woodman, Michael A Davies, Jennifer A Wargo
BACKGROUND: Dual BRAF and MEK inhibition produces a response in a large number of patients with stage IV BRAF-mutant melanoma. The existing standard of care for patients with clinical stage III melanoma is upfront surgery and consideration for adjuvant therapy, which is insufficient to cure most patients. Neoadjuvant targeted therapy with BRAF and MEK inhibitors (such as dabrafenib and trametinib) might provide clinical benefit in this high-risk p opulation. METHODS: We undertook this single-centre, open-label, randomised phase 2 trial at the University of Texas MD Anderson Cancer Center (Houston, TX, USA)...
January 17, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29346535/tricuspid-regurgitation-in-acute-heart-failure-is-there-any-incremental-risk
#14
Diab Mutlak, Jonathan Lessick, Shehrban Khalil, Sergey Yalonetsky, Yoram Agmon, Doron Aronson
Aim: Significant tricuspid regurgitation (TR) is common in heart failure (HF) and portends poor prognosis. We sought to determine whether the poor outcome results from the TR itself, or whether the TR is a surrogate marker of advanced left-sided myocardial or valvular heart disease. Methods and results: We studied 639 patients admitted for acute HF. The relationship between TR severity and the endpoint of readmission for HF or mortality was assessed after adjustment for multiple clinical and echocardiographic parameters...
January 15, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29343992/validation-of-bp-devices-qardioarm%C3%A2-in-the-general-population-and-omron-m6-comfort%C3%A2-in-type-ii-diabetic-patients-according-to-the-european-society-of-hypertension-international-protocol-esh-ip
#15
Mirna N Chahine, Jirar Topouchian, Parounak Zelveian, Zoya Hakobyan, Arevik Melkonyan, Alaa Azaki, Reem Diab, Aya Harb, Roland Asmar
Background: Following the European Society of Hypertension International Protocol (ESH-IP) Revision 2010, QardioArm® and Omron M6 Comfort IT® oscillometric devices were evaluated in the general population and in patients with type II diabetes, respectively, for self-blood pressure (BP) measurement. Methods: Both devices, QardioArm® and Omron M6 Comfort®, measure BP at the brachial level. The ESH-IP Revision 2010 includes a total number of 33 subjects. For each measure, the difference between observer and device BP values was calculated...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29337140/characteristics-and-prognostic-factors-for-patients-with-her2-overexpressing-breast-cancer-and-brain-metastases-in-the-era-of-her2-targeted-therapy-an-argument-for-earlier-detection
#16
Aki Morikawa, Rui Wang, Sujata Patil, Adi Diab, Jonathan Yang, Clifford A Hudis, Heather L McArthur, Kathryn Beal, Andrew D Seidman
BACKGROUND: Although brain metastases (BM) are associated with poor prognosis, patients with human epidermal growth factor receptor 2 (HER2) overexpressing (HER2+) breast cancer (BC) with BM who are treated with anti-HER2 therapy have a relatively longer survival after BM diagnosis compared with other subtypes and HER2+ patients previously untreated with anti-HER2 therapy. It is unclear if previously reported prognostic factors are applicable to patients with HER2+ BC in the era of HER2-targeted therapy...
December 21, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29335188/electrophoretic-deposition-of-single-source-precursors-as-a-general-approach-for-the-formation-of-hybrid-nanorod-array-heterostructures
#17
Michael Volokh, Mahmud Diab, Kobi Flomin, Taleb Mokari
HYPOTHESIS: Subjecting colloids to electric fields often results in (electrophoretic) deposition on conductive substrates. Dispersing a single-source precursor (SSP) of choice in an appropriate solvent, should allow its deposition on different substrates. The SSP-solvent interaction might play a role in the deposition (e.g., direction, rate, coverage). After thermal decomposition, the SSPs convert to the designed material, thus allowing formation of thin films or hybrid nanostructures...
January 9, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29317530/the-polarity-protein-angiomotin-p130-controls-dendritic-spine-maturation
#18
Michael Wigerius, Dylan Quinn, Antonios Diab, Leanne Clattenburg, Annette Kolar, Jiansong Qi, Stefan R Krueger, James P Fawcett
The actin cytoskeleton is essential for the structural changes in dendritic spines that lead to the formation of new synapses. Although the molecular mechanisms underlying spine formation are well characterized, the events that drive spine maturation during development are largely unknown. In this study, we demonstrate that Angiomotin (AMOT-130) is necessary for spine stabilization. AMOT-130 is enriched in mature dendritic spines and functions to stabilize the actin cytoskeleton by coupling F-actin to postsynaptic protein scaffolds...
January 9, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29313066/retraction-note-to-quinoxaline-1-4-dioxides-induce-g2-m-cell-cycle-arrest-and-apoptosis-in-human-colon-cancer-cells
#19
Hala U Gali-Muhtasib, Mona Diab-Assaf, Makhluf J Haddadin
The authors have retracted this article because of overlap in images within the publication and with another previously published article. It was brought to our attention that there are inconsistencies in Figs. 3, 5 and 6. The left middle panel in Fig. 3, labeled "Ctrl", is the same as the left panel in Fig. 6, labeled "PD98059", except that the latter is flipped upside down and right-left. In Fig. 5, the gel in the middle left panel labeled TGF-β2 has been cropped in two different ways and used in Figs...
January 8, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29291376/intraoperative-implantation-of-micra-leadless-pacemaker-during-valve-surgery
#20
Ibrahim Marai, Sammer Diab, Ronny Ben-Avi, Erez Kachel
The Micra transcatheter leadless pacemaker, a single chamber leadless ventricular pacemaker, is implanted percutanneously through femoral vein. We present a case of patient in whom, Micra leadless pacemaker was implanted during valve surgery.
December 29, 2017: Annals of Thoracic Surgery
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