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https://www.readbyqxmd.com/read/28685475/a-new-hereditary-colorectal-cancer-network-in-the-middle-east-and-eastern-mediterranean-countries-to-improve-care-for-high-risk-families
#1
Zeinab Ghorbanoghli, Carol Jabari, Walid Sweidan, Wail Hammoudeh, George Cortas, Ala I Sharara, Amal Abedrabbo, Ijad Hourani, Bahareh Mahjoubi, Keivan Maijdzadeh, Nurdan Tözün, Hadia Ziada-Bouchaar, Waseem Hamoudi, Osama Diab, Hamid Reza Khorram Khorshid, Henry Lynch, Hans Vasen
Colorectal cancer (CRC) has a very high incidence in the western world. Data from registries in the Middle East showed that the incidence of CRC is relatively low in these countries. However, these data also showed that CRC incidence has increased substantially over the past three decades and that a high proportion of cases are diagnosed at an early age (<50 years). In view of these findings, more attention should be paid to prevention. Because of the often limited financial resources, focused screening of individuals with hereditary CRC, in particular those with Lynch syndrome, appears to be the most cost-effective strategy...
July 6, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28681687/retrospective-study-of-fatal-pneumonia-in-racehorses
#2
Francisco R Carvallo, Francisco A Uzal, Santiago S Diab, Ashley E Hill, Rick M Arthur
Respiratory diseases have a major impact on racehorses in training and are often cited as the second most common reason of horses failing to perform. Cases were submitted by the California Horse Racing Board to the California Animal Health and Food Safety laboratory for postmortem examination between January 1, 2005 and December 31, 2014. We determined the demographics of racehorses with fatal pneumonia, characterized the pathologic findings in animals with a postmortem diagnosis of respiratory infection, and determined the most significant pathogens associated with lower respiratory tract disease...
July 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28676244/diagnostic-yield-of-cardiovascular-magnetic-resonance-in-young-middle-aged-patients-with-high-grade-atrio-ventricular-block
#3
A Baritussio, A Ghosh Dastidar, A Frontera, N Ahmed, E De Garate, I Harries, I Diab, E Duncan, G Thomas, A Nisbet, C Bucciarelli-Ducci
BACKGROUND: Atrio-ventricular block (AVB) is a rare finding in young or middle-aged adults, often leading to pacemaker implantation (PM) without further investigation. We sought to assess the diagnostic role of cardiovascular magnetic resonance (CMR) in young and middle-aged adults with high-grade AVB. METHODS: We consecutively enrolled young-middle aged (18-65years) patients with high grade AVB referred to CMR after standard clinical assessment (history, electrocardiogram and cardiac rhythm monitoring) prior to PM implantation...
June 21, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28670915/phytochemical-and-pharmacological-properties-of-essential-oils-from-cedrus-species
#4
Antoine M Saab, Roberto Gambari, Gianni Sacchetti, Alessandra Guerrini, Ilaria Lampronti, Massimo Tacchini, Antoine El Samrani, Samir Medawar, Hassane Makhlouf, Mona Tannoury, Jihad Abboud, Mona Diab-Assaf, Anake Kijjoa, Rosa Tundis, Jawad Aoun, Thomas Efferth
Natural products frequently exert pharmacological activities. The present review gives an overview of the ethnobotany, phytochemistry and pharmacology of the Cedrus genus, e.g. cytotoxic, spasmolytic immunomodulatory, antiallergic, anti-inflammatory and analgesic activities. Cancer patients frequently seek remedies from traditional medicinal plants that are believed to exert less side effects than conventional therapy with synthetic drugs. A long-lasting goal of anti-cancer and anti-microbial therapy research is to find compounds with reduced side effects compared to currently approved drugs...
July 3, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28649381/new-cancer-immunotherapy-agents-in-development-a-report-from-an-associated-program-of-the-31-st-annual-meeting-of-the-society-for-immunotherapy-of-cancer-2016
#5
REVIEW
Prasad S Adusumilli, Edward Cha, Mark Cornfeld, Thomas Davis, Adi Diab, Thomas W Dubensky, Elizabeth Evans, Jane L Grogan, Bryan A Irving, Rom S Leidner, Shane A Olwill, Patrick Soon-Shiong, Frederic Triebel, David Tuck, Adrian Bot, Roger D Dansey, Charles G Drake, Gordon J Freeman, Ramy Ibrahim, Salil Patel, Daniel S Chen
This report is a summary of 'New Cancer Immunotherapy Agents in Development' program, which took place in association with the 31st Annual Meeting of the Society for Immunotherapy of Cancer (SITC), on November 9, 2016 in National Harbor, Maryland. Presenters gave brief overviews of emerging clinical and pre-clinical immune-based agents and combinations, before participating in an extended panel discussion with multidisciplinary leaders, including members of the FDA, leading academic institutions and industrial drug developers, to consider topics relevant to the future of cancer immunotherapy...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28636186/views-of-general-practice-staff-about-the-use-of-a-patient-oriented-treatment-decision-aid-in-shared-decision-making-for-patients-with-type-2-diabetes-a-mixed-methods-study
#6
Anita Wildeboer, Esther du Pon, Jan Schuling, Flora M Haaijer-Ruskamp, Petra Denig
BACKGROUND: Decision aids can be used to support shared decision making (SDM). A patient-oriented treatment decision aid (DA) was developed for type 2 diabetes but its use by general practice staff appeared to be limited. OBJECTIVES: To explore views of practice staff towards SDM and the DA. DESIGN: A mixed-methods study within the Dutch PORTDA-diab trial. SETTING AND PARTICIPANTS: Included were 17 practices with staff members who were responsible for routine diabetes care and had worked with the DA, and 209 of their patients...
June 21, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28631687/-acquired-atresia-and-stenosis-of-the-external-acoustic-meatus
#7
D S Kondratchikov, Kh M Diab, V S Korvyakov, L I Terekhina
Acquired atresia of the external acoustic meatus is a rare pathological condition characterized by obliteration of the medial part of the external acoustic canal by a soft fibrous plug. The present article presents an overview of a series of cases of acquired atresia and stenosis of the external acoustic meatus with the description of etiology, pathogenesis, and methods for the treatment of this condition. In the majority of the cases, atresia develops at the final stage of granulation external otitis with or without an accompanying dermatological pathology...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28627432/high-diversity-of-multidrug-resistant-mycobacterium-tuberculosis-central-asian-strain-isolates-in-nepal
#8
Yogendra Shah, Bhagwan Maharjan, Jeewan Thapa, Ajay Poudel, Hassan Mahmoud Diab, Basu Dev Pandey, Eddie Solo, Norikazu Isoda, Yasuhiko Suzuki, Chie Nakajima
OBJECTIVES: Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) poses a major public health problem in Nepal. Although it has been reported as one of the dominant genotypes of MTB in Nepal, little information on the Central Asian Strain (CAS) family is available, especially isolates related to multidrug resistance (MDR) cases. This study aimed to elucidate the genetic and epidemiological characteristics of MDR CAS isolates in Nepal. METHODS: A total of 145 MDR CAS isolates collected in Nepal from 2008 to 2013 were characterized by spoligotyping, mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) analysis, and drug resistance-associated gene sequencing...
June 13, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28625205/why-suicide-the-analysis-of-motives-for-self-harm
#9
Mohammed J Abbas, Mostafa A Mohanna, Tarig A Diab, Millicent Chikoore, Michael Wang
BACKGROUND: There is a gap in understanding the meaning and motives behind suicidal behaviour. Using the Ideal Type methodology, Jean Baechler systematically examined the internal logic of suicidal and self-harming behaviours. He developed a typology of eleven typical meanings/motives: Flight, Grief, Self-punishment, Vengeance, Crime, Blackmail, Appeal, Sacrifice, Transfiguration, Ordeal and Game. AIMS: To develop and validate a standardized instrument to measure the motives/meanings of suicidal and self-harming behaviours, using Baechler's typology...
June 19, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28619421/the-protective-role-of-maternal-posttraumatic-growth-and-cognitive-trauma-processing-among-palestinian-mothers-and-infants
#10
Safwat Y Diab, Sanna Isosävi, Samir R Qouta, Saija Kuittinen, Raija-Leena Punamäki
War survivors use multiple cognitive and emotional processes to protect their mental health from the negative impacts of trauma. Because mothers and infants may be especially vulnerable to trauma in conditions of war, it is urgent to determine which cognitive and emotional processes are effective for preventing negative trauma impacts." This study examined whether mothers' high posttraumatic growth (PTG) and positive posttraumatic cognitions (PTC) protected (a) their own mental health and (b) their infants' stress regulation and sensorimotor and language development from the effects of war trauma...
June 12, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28617886/major-hereditary-gastrointestinal-cancer-syndromes-a-narrative-review
#11
REVIEW
Lakshmi Manogna Chintalacheruvu, Trudy Shaw, Avanija Buddam, Osama Diab, Thamer Kassim, Sandeep Mukherjee, Henry T Lynch
Gastrointestinal cancer is one of the major causes of death worldwide. Hereditary gastrointestinal cancer syndromes constitute about 5-10% of all cancers. About 20-25% of undiagnosed cases have a possible hereditary component, which is not yet established. In the last few decades, the advance in genomics has led to the discovery of multiple cancer predisposition genes in gastrointestinal cancer. Physicians should be aware of these syndromes to identify high-risk patients and offer genetic testing to prevent cancer death...
June 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28608691/impact-of-reabsorption-on-the-emission-spectra-and-recombination-dynamics-of-hybrid-perovskite-single-crystals
#12
Hiba Diab, Christophe Arnold, Ferdinand Lédée, Gaëlle Trippé-Allard, Géraud Delport, Christèle Vilar, Fabien Bretenaker, Julien Barjon, Jean-Sébastien Lauret, Emmanuelle Deleporte, Damien Garrot
Understanding the surface properties of organic-inorganic lead-based perovskites is of high importance to improve the device's performance. Here, we have investigated the differences between surface and bulk optical properties of CH3NH3PbBr3 single crystals. Depth-resolved cathodoluminescence was used to probe the near-surface region on a depth of a few microns. In addition, we have studied the transmitted luminescence through thicknesses between 50 and 600 μm. In both experiments, the expected spectral shift due to the reabsorption effect has been precisely calculated...
June 15, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28584775/evaluation-of-periodontal-status-and-treatment-needs-of-institutionalized-intellectually-disabled-individuals-in-lebanon
#13
Hicham A Diab, Ghassan N Hamadeh, Fouad Ayoub
AIMS AND OBJECTIVES: No reported data is available on the periodontal health and treatment needs of the intellectually disabled in Lebanon. To evaluate the periodontal condition and treatment needs of institutionalized intellectually disabled individuals in Lebanon. MATERIALS AND METHODS: A total of 272 individuals (141 males and 131 females) aged 15 years and 35-44 years were examined. Periodontal health was recorded following the community periodontal index of treatment needs (CPITN), and treatment need was assigned accordingly...
May 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28578971/printing-and-impact-properties-of-cationised-hollow-cellulosic-fiber-based-polyester-cotton-composite
#14
O A Hakeim, H A Diab, H M Mashaly, Amal Mohamed El-Moursy
Hollow fibers materials have been potentially used and gaining increasing attention in recent years. In this study, Egyptian hollow fibers have been blended with cotton and polyester wastes at different weft counts using open-end spinning. The blended fabrics were subjected for cationisation followed by printing with reactive and acid dyes. The performance of impact properties of cationised hollow fiber reinforced polyester/cotton hybrid composites was studied. The results demonstrated that the physical and color properties of blended fabrics are greatly influenced by alkali pretreatment and cationisation of hybrid composites as well as the weft counts...
September 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28567162/cytomegalovirus-macrophages-and-breast-cancer
#15
REVIEW
S Pasquereau, F Al Moussawi, W Karam, M Diab Assaf, A Kumar, G Herbein
The human cytomegalovirus (HCMV) is a betaherpesvirus that is highly host specific, infects among others epithelial cells and macrophages, and has been recently mentioned as having oncomodulatory properties. HCMV is detected in the breast tumor tissue where macrophages, especially tumor associated macrophages, are associated with a poor prognosis. In this review, we will discuss the potential implication of HCMV in breast cancer with emphasis on the role played by macrophages.
2017: Open Virology Journal
https://www.readbyqxmd.com/read/28556692/war-trauma-and-maternal-fetal-attachment-predicting-maternal-mental-health-infant-development-and-dyadic-interaction-in-palestinian-families
#16
Raija-Leena Punamäki, Sanna Isosävi, Samir R Qouta, Saija Kuittinen, Safwat Y Diab
Optimal maternal-fetal attachment (MFA) is believed to be beneficial for infant well-being and dyadic interaction, but research is scarce in general and among risk populations. Our study involved dyads living in war conditions and examined how traumatic war trauma associates with MFA and which factors mediate that association. It also modeled the role of MFA in predicting newborn health, infant development, mother-infant interaction, and maternal postpartum mental health. Palestinian women from the Gaza Strip (N = 511) participated during their second trimester (T1), and when their infants were 4 (T2) and 12 (T3) months...
May 30, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/28551658/preoperative-ca-125-values-as-a-predictive-factor-for-the-postoperative-outcome-in-primary-serous-ovarian-cancer
#17
Mustafa Zelal Muallem, Asya Parashkevova, Jumana Almuheimid, Rolf Richter, Yasser Diab, Elena Ioana Braicu, Jalid Sehouli
BACKGROUND/AIM: The purpose of the study was to examine the preoperative CA-125 values as a predictive factor for postoperative outcome in primary serous ovarian cancer (POC) for complete tumor resection (CTR) and evaluate the preoperative CA-125 levels with other vital clinical dynamics such as ascites, lymph node involvement, diffuse peritoneal carcinomatosis, grading and staging. PATIENTS AND METHODS: A cohort of 277 POC-patients aged 18-75 years, who had undergone primary cytoreductive surgery at the Department of Gynecology & Oncological Surgery, Charité, Campus Virchow Klinikum (CVK) between 2000 und 2009 was analyzed in correlation with the preoperative CA-125 values...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551615/targeted-therapy-in-ovarian-cancer-a-comprehensive-systematic-review-of-literature
#18
REVIEW
Yasser Diab, Mustafa Zelal Muallem
BACKGROUND/AIM: We aimed to identify the most effectual groups of targeted therapies for ovarian cancer in recent clinical trials. MATERIALS AND METHODS: A systematic literature review has been gathered on an inventive study design that comprises of five steps. This involves search for pertinent publications from 2010 to date in various accessible medical data bases, usage of inclusion and exclusion, appraisal of quality of the studies included, abstraction of the relevant data and intelligible amalgamation of the data abridged in an evocative and narrative style...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28541427/percutaneous-cannulation-for-cardiopulmonary-bypass-in-minimally-invasive-surgery-is-associated-with-reduced-groin-complications
#19
Alexandros Moschovas, Paulo A Amorim, Mariana Nold, Gloria Faerber, Mahmoud Diab, Tobias Buenger, Torsten Doenst
OBJECTIVES: Femoral cutdown is standard in most centres if groin cannulation is used for cardiopulmonary bypass in minimally invasive cardiac surgery (MICS). Arterial closure devices (ACDs) allow placement of larger cannulas percutaneously, but its benefit in MICS is unclear. We assessed our results with percutaneous groin cannulation using ACDs in comparison with conventional surgical access in patients undergoing MICS. METHODS: We reviewed 445 consecutive patients having undergone MICS between October 2010 and March 2015...
May 25, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28520696/an-ovine-model-of-hyperdynamic-endotoxemia-and-vital-organ-metabolism
#20
Liam Byrne, Nchafatso G Obonyo, Sara Diab, Kimble Dunster, Margaret Passmore, Ai Ching Boon, Louise See Hoe, Karen Hay, Frank Van Haren, John-Paul Tung, Louise Cullen, Kiran Shekar, Kathryn Maitland, John F Fraser
BACKGROUND: Animal models of endotoxemia are frequently used to understand the pathophysiology of sepsis and test new therapies. However, important differences exist between commonly used experimental models of endotoxemia and clinical sepsis. Animal models of endotoxemia frequently produce hypodynamic shock in contrast to clinical hyperdynamic shock. This difference may exaggerate the importance of hypoperfusion as a causative factor in organ dysfunction. This study sought to develop an ovine model of hyperdynamic endotoxemia and assess if there is evidence of impaired oxidative metabolism in the vital organs...
May 17, 2017: Shock
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