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https://www.readbyqxmd.com/read/28520696/an-ovine-model-of-hyperdynamic-endotoxemia-and-vital-organ-metabolism
#1
Liam Byrne, Nchafatso G Obonyo, Sara Diab, Kimble Dunster, Margaret Passmore, Ai Ching Boon, Louise See Hoe, Karen Hay, Frank Van Haren, John-Paul Tung, Louise Cullen, Kiran Shekar, Kathryn Maitland, John F Fraser
BACKGROUND: Animal models of endotoxemia are frequently used to understand the pathophysiology of sepsis and test new therapies. However, important differences exist between commonly used experimental models of endotoxemia and clinical sepsis. Animal models of endotoxemia frequently produce hypodynamic shock in contrast to clinical hyperdynamic shock. This difference may exaggerate the importance of hypoperfusion as a causative factor in organ dysfunction. This study sought to develop an ovine model of hyperdynamic endotoxemia and assess if there is evidence of impaired oxidative metabolism in the vital organs...
May 17, 2017: Shock
https://www.readbyqxmd.com/read/28507619/expression-of-erg-protein-and-tmrpss2-erg-fusion-in-prostatic-carcinoma-in-egyptian-patients
#2
Ahmed Abdel-Hady, Ali El-Hindawi, Olfat Hammam, Heba Khalil, Sara Diab, Soulafa Abd El-Aziz, Mohamed Badawy, Ahmed Ismail, Noha Helmy, Nora Kamel, Shady Anis, Amr El Kholy, Khalid Al Osili, Afaf Abdel-Hady, Hani Nour, Maha Akl
AIM: Prostate cancer (PCa) is the second most common cancers in men worldwide. Its incidence can be influenced by several risk factors including genetic susceptibility. Therefore the search for the expression of a certain gene (ERG) and its rearrangement could give us clues for proper identification of PCa. And the study of ERG expression and its comparison to FISH in Egyptian patients can show whether ERG immunophenotype could be used instead of FISH, as it is cheaper. MATERIALS AND METHODS: This study was performed on 85 cases of PCa, showing 30 cases with HGPIN and 30 cases of prostatic hyperplasia...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28496964/oral-health-status-of-institutionalized-individuals-with-intellectual-disabilities-in-lebanon
#3
Hicham A Diab, Ziad Salameh, Ghassan N Hamadeh, Genane Younes, Fouad Ayoub
OBJECTIVES: To assess the dental status of institutionalized intellectually disabled individuals in Lebanon and the role of background and behavioural determinants. MATERIAL AND METHODS: Oral health was recorded for 652 individuals (6, 12, 15 and 35 - 44 years old) using the decayed, missing and filled teeth/decayed and filled teeth (DMFT/dft) index. Data collected was statistically analysed with statistical significance set at P = 0.05. RESULTS: Overall, mean DMFT index score was 5...
January 2017: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/28495698/pulmonary-arterial-hypertension-screening-challenges-in-systemic-sclerosis-and-future-directions
#4
EDITORIAL
Nermin Diab, Paul M Hassoun
No abstract text is available yet for this article.
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28488146/ecological-and-agriculture-impacts-of-bakery-yeast-wastewater-use-on-weed-communities-and-crops-in-an-arid-environment
#5
Mohammed H Abu-Dieyeh, Mahmoud Diab, Mohammad A Al-Ghouti
The goal of this study was to evaluate the impact of using yeast wastewater (YW) on weed communities. The study showed that all ecological parameters including species richness, dispersion, density, frequency, and % of vegetation cover were significantly increased in the site irrigated with YW compared to a natural rain fed site and another site irrigated with fresh water. The vegetation cover (%) was significantly increased by 2-folds in the site irrigated with YW (52%) than the one irrigated with fresh water (27%)...
May 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28473052/silica-based-systems-for-oral-delivery-of-drugs-macromolecules-and-cells
#6
REVIEW
Roudayna Diab, Nadia Canilho, Ileana A Pavel, Fernanda B Haffner, Maxime Girardon, Andreea Pasc
According to the US Food and Drug Administration and the European Food Safety Authority, amorphous forms of silica and silicates are generally recognized to be safe as oral delivery ingredients in amounts up to 1500mg per day. Silica is used in the formulation of solid dosage forms, e.g. tablets, as glidant or lubricant. The synthesis of silica-based materials depends on the payload nature, drug, macromolecule or cell, and on the target release (active or passive). In the literature, most of the examples deal with the encapsulation of drugs in mesoporous silica nanoparticles...
April 20, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28462185/a-survey-of-oral-health-in-institutionalized-population-with-intellectual-disabilities-comparison-with-a-national-oral-health-survey-of-the-normal-population
#7
Hicham A Diab, Ghassan N Hamadeh, Fouad Ayoub
INTRODUCTION: Compared to the general population, the intellectually-disabled (ID) experience poor health and inferior access to high quality health services. AIM: To compare the oral health of institutionalized ID Lebanese individuals to that of the normal Lebanese population (NLP). MATERIALS AND METHODS: Caries and periodontal indices were recorded in 652 ID individuals (aged 6, 12, 15, and 35-44 years) residing in the 5 major Lebanese governorates...
March 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28447973/methods-to-study-lipid-alterations-in-neutrophils-and-the-subsequent-formation-of-neutrophil-extracellular-traps
#8
Graham Brogden, Ariane Neumann, Diab M Husein, Friederike Reuner, Hassan Y Naim, Maren von Köckritz-Blickwede
Lipid analysis performed by high performance thin layer chromatography (HPTLC) is a relatively simple, cost-effective method of analyzing a broad range of lipids. The function of lipids (e.g., in host-pathogen interactions or host entry) has been reported to play a crucial role in cellular processes. Here, we show a method to determine lipid composition, with a focus on the cholesterol level of primary blood-derived neutrophils, by HPTLC in comparison to high performance liquid chromatography (HPLC). The aim was to investigate the role of lipid/cholesterol alterations in the formation of neutrophil extracellular traps (NETs)...
March 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28445592/polo-like-kinase-1-is-a-proviral-host-factor-for-hepatitis-b-virus-replication
#9
Ahmed M Diab, Adrien Foca, Floriane Fusil, Thomas Lahlali, Pascal Jalaguier, Fouzia Amirache, Lia N'Guyen, Nathalie Isorce, François-Loïc Cosset, Fabien Zoulim, Ourania M Andrisani, David Durantel
Chronic Hepatitis B Virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC) and current treatments for CHB and HCC are perfectible. Herein, we identified cellular Serine/Threonine Polo-like-kinase 1 (PLK1) as a positive effector of HBV replication. The aim of this study was to demonstrate the proviral role of PLK1 in HBV biosynthesis and validate PLK1 inhibition a potential antiviral strategy. To this end, we employed physiologically relevant HBV infection models of Primary Human Hepatocytes (PHH) and differentiated HepaRG cells, in conjunction with pharmacologic PLK1 inhibitors, siRNA-mediated knockdown, and overexpression of constitutively active PLK1 (PLK1(CA) )...
April 26, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28442930/thoracic-epidural-analgesia-reduces-myocardial-injury-in-ischemic-patients-undergoing-major-abdominal-cancer-surgery
#10
Mohamad Farouk Mohamad, Montaser A Mohammad, Diab F Hetta, Eman Hasan Ahmed, Ahmed A Obiedallah, Alaa Ali M Elzohry
BACKGROUND AND OBJECTIVES: Major abdominal cancer surgeries are associated with significant perioperative mortality and morbidity due to myocardial ischemia and infarction. This study examined the effect of perioperative patient controlled epidural analgesia (PCEA) on occurrence of ischemic cardiac injury in ischemic patients undergoing major abdominal cancer surgery. PATIENTS AND METHODS: One hundred and twenty patients (American Society of Anesthesiologists grade II and III) of either sex were scheduled for elective upper gastrointestinal cancer surgeries...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28421608/can-functional-emotion-regulation-protect-children-s-mental-health-from-war-trauma-a-palestinian-study
#11
Marwan Diab, Kirsi Peltonen, Samir R Qouta, Esa Palosaari, Raija-Leena Punamäki
Effective emotion regulation (ER) is expected to protect mental health in traumatic stress. We first analysed the protective (moderator) function of different ER strategies and the associations between ER and mental health. Second, we tested gender differences in the protective function of ER and the associations between ER strategies and mental health. Participants were 482 Palestinian children (girls 49.4%; 10-13 years, M = 11.29, SD = .68) whose ER was assessed by the Emotion Regulation Questionnaire and mental health by post-traumatic stress (Children's Impact Event Scale), depressive, and psychological distress (Strengths and Difficulties Questionnaire) symptoms, and by psychosocial well-being (Mental Health Continuum-Short Form)...
April 19, 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28406660/maternal-pre-and-postnatal-mental-health-and-infant-development-in-war-conditions-the-gaza-infant-study
#12
Raija-Leena Punamäki, Safwat Y Diab, Sanna Isosävi, Saija Kuittinen, Samir R Qouta
OBJECTIVE: Women and their infants need special protection in war context, as traumatic events can risk maternal mental and obstetric health and compromise infant development. This prospective study examined, first, how exposure to war trauma is associated with maternal mental health in pregnancy and postpartum, obstetric and newborn health, and infant development. Second, it tested the role of maternal mental health and obstetric risks in mediating between war trauma and infant development...
April 13, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28396989/cardiac-surgery-2016-reviewed
#14
REVIEW
Torsten Doenst, Yasin Essa, Khalil Jacoub, Alexandros Moschovas, David Gonzalez-Lopez, Hristo Kirov, Mahmoud Diab, Steffen Bargenda, Gloria Faerber
For the year 2016, more than 20,000 published references can be found in Pubmed when entering the search term "cardiac surgery". Publications last year have helped to more clearly delineate the fields where classic surgery and modern interventional techniques overlap. The field of coronary bypass surgery (partially compared to percutaneous coronary intervention) was enriched by five large prospective randomized trials. The value of CABG for complex coronary disease was reconfirmed and for less complex main stem lesions, PCI was found potentially equal...
April 10, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28391798/story-immersion-may-be-effective-in-promoting-diet-and-physical-activity-in-chinese-children
#15
Jing Jing Wang, Tom Baranowski, Patrick W C Lau, Richard Buday, Yang Gao
OBJECTIVE: To evaluate the effect of playing a health video game embedded with story immersion, Escape from Diab (Diab), on children's diet and physical activity (PA) and to explore whether children immersed in Diab had greater positive outcomes. DESIGN: Two groups, nonrandomized; 3 outcome assessments: at baseline, immediately after the game (post 1), and 8-10 weeks after the game (post 2). PARTICIPANTS: A total of 179 Chinese children aged 8-12 years...
April 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28381258/metabolomic-profiling-in-patients-undergoing-off-pump-or-on-pump-coronary-artery-bypass-surgery
#16
H Kirov, M Schwarzer, S Neugebauer, G Faerber, M Diab, T Doenst
BACKGROUND: Coronary artery bypass surgery can be performed without (Off-Pump) or with cardiopulmonary bypass (On-Pump). Extracorporeal circulation and cardioplegic arrest may cause alterations in the plasma metabolome. We assessed metabolomic changes in patients undergoing On-Pump or Off-Pump coronary artery bypass surgery. METHODS: We assessed five analyte classes (41 acylcarnitines, 14 amino acids, 92 glycerophospholipids, 15 sphingolipids, sugars, lactate) using a mass-spectrometry-based kit (Biocrates AbsoluteIDQ® p150) in paired arterial and coronary sinus blood obtained from 10 consecutive On-Pump and 10 Off-Pump patients...
April 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28372660/airborne-bacterial-contamination-during-orthopedic-surgery-a-randomized-controlled-pilot-trial
#17
Ruken Oguz, Magda Diab-Elschahawi, Jutta Berger, Nicole Auer, Astrid Chiari, Ojan Assadian, Oliver Kimberger
STUDY OBJECTIVE: Several factors such as lack of unidirectional, turbulent free laminar airflow, duration of surgery, patient warming system, or the number of health professionals in the OR have been shown or suspected to increase the number of airborne bacteria. The objective of this study was to perform a multivariate analysis of bacterial counts in the OR in patients during minor orthopedic surgery. DESIGN: Prospective, randomized pilot study. SETTING: Medical University of Vienna, Austria...
May 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28364480/treatment-solution-treatment-of-choice-in-a-case-of-haemodynamic-instability-after-endovascular-repair-of-a-complicated-acute-type-b-aortic-dissection
#18
Clarence Pingpoh, Nawras Diab, Bartek Rylski, Matthias Siepe
No abstract text is available yet for this article.
February 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28363209/successful-transvenous-cardiac-resynchronisation-therapy-in-a-case-of-coronary-sinus-ostial-atresia
#19
David Wilson, Nauman Ahmed, Phoebe Sun, Ihab Diab
No abstract text is available yet for this article.
February 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28347286/malignant-acrospiroma-a-case-report-in-the-era-of-next-generation-sequencing
#20
Maria Diab, Ali Gabali, Muaiad Kittaneh
BACKGROUND: Malignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. Typically, it presents as large ulcerated nodules, and diagnosis can be challenging as it has great overlap with its benign counterpart. CASE PRESENTATION: We herein report a case of acral malignant acrospiroma, initially treated with surgical excision and adjuvant radiotherapy. After metastatic disease was confirmed, subject received multiple lines of chemo- as well as targeted therapy...
March 27, 2017: BMC Cancer
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