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https://www.readbyqxmd.com/read/29239052/impact-of-anxiety-on-the-satisfaction-of-dental-implant-patients
#1
Afya Sahib Diab Al-Radha
PURPOSE: To study the influence of anxiety on dental implant patient satisfaction, and to explore if hemoglobin levels and the amount of body fat affected patient satisfaction. MATERIALS AND METHODS: One hundred three partially edentulous patients (mean age 42.06 years) who had received dental implant therapy were enrolled in the study. Self-administered questionnaires were given to those patients to evaluate their level of satisfaction with implant treatment. The State-Trait Anxiety Inventory (STAI) self-reported questionnaire was used to determine anxiety levels...
December 14, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29237404/computed-tomography-scan-based-prediction-of-the-vulnerable-carotid-plaque
#2
Hadi Mahmoud Haider Diab, Lars Melholt Rasmussen, Stevo Duvnjak, Axel Diederichsen, Pia Søndergaard Jensen, Jes Sanddal Lindholt
BACKGROUND: Primary to validate a commercial semi-automated computed tomography angiography (CTA) -software for vulnerable plaque detection compared to histology of carotid endarterectomy (CEA) specimens and secondary validating calcifications scores by in vivo CTA with ex vivo non-contrast enhanced computed tomography (NCCT). METHODS: From January 2014 to October 2016 53 patients were included retrospectively, using a cross-sectional design. All patients underwent both CTA and CEA...
December 13, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/29235867/nfgail-amyloid-oligomers-the-onset-of-beta-sheet-formation-and-the-mechanism-for-fibril-formation
#3
Waldemar Hoffmann, Kristin Folmert, Johann Moschner, Xing Huang, Hans von Berlepsch, Beate Koksch, Michael T Bowers, Gert von Helden, Kevin Pagel
The hexapeptide NFGAIL is a highly amyloidogenic peptide, derived from the human islet amyloid polypeptide (hIAPP). Recent investigations indicate that presumably soluble hIAPP oligomers are one of the cytotoxic species in type II diabe-tes. Here we use Thioflavin T staining, transmission electron microscopy as well as ion mobility-mass spectrometry coupled to infrared (IR) spectroscopy to study the amyloid formation mechanism and the quaternary- and secondary-structure of soluble NFGAIL oligomers. Our data reveal that at neutral pH NFGAIL follows a nucleation-dependent mechanism to form amyloid fibrils...
December 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29234093/crispr-cas9-microinjection-in-oocytes-disables-pancreas-development-in-sheep
#4
Marcela Vilarino, Sheikh Tamir Rashid, Fabian Patrik Suchy, Bret Roberts McNabb, Talitha van der Meulen, Eli J Fine, Syed Ahsan, Nurlybek Mursaliyev, Vittorio Sebastiano, Santiago Sain Diab, Mark O Huising, Hiromitsu Nakauchi, Pablo J Ross
One of the ultimate goals of regenerative medicine is the generation of patient-specific organs from pluripotent stem cells (PSCs). Sheep are potential hosts for growing human organs through the technique of blastocyst complementation. We report here the creation of pancreatogenesis-disabled sheep by oocyte microinjection of CRISPR/Cas9 targeting PDX1, a critical gene for pancreas development. We compared the efficiency of target mutations after microinjecting the CRISPR/Cas9 system in metaphase II (MII) oocytes and zygote stage embryos...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233377/application-of-a-systematic-approach-to-evaluating-psychometric-properties-of-a-cumulative-exit-from-degree-objective-structured-clinical-examination-osce
#5
Ahmed Hesham Sobh, Zubin Austin, Mohamed Izham M I, Mohammad I Diab, Kyle John Wilby
BACKGROUND AND PURPOSE: Objective structured clinical examinations (OSCEs) are considered gold standard performance-based assessments yet comprehensive evaluation data is currently lacking. The objective of this study was to critically evaluate the psychometric properties of a cumulative OSCE for graduating pharmacy students in Qatar for which policies and procedures were adapted from a Canadian context. EDUCATIONAL ACTIVITY AND SETTING: A 10-station OSCE was conducted for graduating students in Qatar...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29229038/the-opportunities-and-limitations-of-minimally-invasive-cardiac-surgery
#6
Torsten Doenst, Mahmoud Diab, Christoph Sponholz, Michael Bauer, Gloria Färber
BACKGROUND: Over the past two decades, minimally invasive techniques for classic heart valve surgery and isolated bypass surgery have been developed that enable access to the heart via partial sternotomy for most aortic valve procedures and via sternotomy-free mini-thoracotomy for other procedures. METHODS: We review the current evidence on minimally invasive cardiac surgery on the basis of pertinent randomized studies and database studies retrieved by a selective search in the MEDLINE and PubMed Central databases, as well as by the Google Scholar search engine...
November 17, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29213165/prevalence-of-helicobacter-pylori-among-sudanese-children-admitted-to-a-specialized-children-hospital
#7
Karimeldin M A Salih, Omer A Elfaki, Yassin H M Hamid, Widad M A Eldouch, Mona Diab, Sulafa O Abdelgadir
The infection by Helicobacter Pylori (HP), a gram-negative bacillus, is more prevalent in the developing countries, and more often among younger people reaching up to 10% of the population in comparison to only 0.5% in more developed world. Generally HP is asymptomatic in children. This study aimed to determining the prevalence of Hp among Sudanese children and to recognize associated epidemiological features. It was a prospective cross sectional study at Gaafar Ibn Aouf children hospital (GCH) in the period between December 2010 and May 2011...
2017: Sudanese Journal of Paediatrics
https://www.readbyqxmd.com/read/29184438/efficacy-of-local-dexmedetomidine-add-on-for-spermatic-cord-block-anesthesia-in-patients-undergoing-intrascrotal-surgeries-randomized-controlled-multicenter-clinical-trial
#8
Diab Fuad Hetta, Emad E Kamal, Ali M Mahran, Doaa G Ahmed, Abdelraheem Elawamy, Abdelraouf Ms Abdelraouf
Study objective: The objective of this study was to evaluate the effect of adding dexmedetomidine (DEX) to bupivacaine on the quality of spermatic cord block anesthesia and postoperative analgesia. Design: This is a randomized, double-blind study. Setting: This study was performed in an educational and research hospital. Patients: One hundred twenty adult males were scheduled for intrascrotal surgeries. Interventions: Patients were divided into two groups: group B received 10 mL of bupivacaine 0...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29183719/the-diverse-functions-of-the-hepatitis-b-core-capsid-protein-hbc-in-the-viral-life-cycle-implications-for-the-development-of-hbc-targeting-antivirals
#9
REVIEW
Ahmed Diab, Adrien Foca, Fabien Zoulim, David Durantel, Ourania Andrisani
Virally encoded proteins have evolved to perform multiple functions, and the core protein (HBc) of the hepatitis B virus (HBV) is a perfect example. While HBc is the structural component of the viral nucleocapsid, additional novel functions for the nucleus-localized HBc have recently been described. These results extend for HBc, beyond its structural role, a regulatory function in the viral life cycle and potentially a role in pathogenesis. In this article, we review the diverse roles of HBc in HBV replication and pathogenesis, emphasizing how the unique structure of this protein is key to its various functions...
November 25, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29178779/synthesis-of-bis-phosphate-iminoaltritol-enantiomers-and-structural-characterization-with-adenine-phosphoribosyltransferase
#10
Lawrence D Harris, Rajesh K Harijan, Rodrigo G Ducati, Gary B Evans, Brett M Hirsch, Vern L Schramm
Phosphoribosyl transferases (PRTs) are essential in nucleotide synthesis and salvage, amino acid and vitamin synthesis. Transition state analysis of several PRTs has demonstrated ribocation-like transition states with a partial positive charge residing on the pentose ring. Core chemistry for synthesis of transition state analogues related to the 5-phospho--D-ribosyl 1-pyrophosphate (PRPP) reactant of these enzymes could be developed by stereospecific placement of bis-phosphate groups on an iminoaltritol ring...
November 27, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29175717/tibio-calcaneal-fusion-by-retrograde-intramedullary-nailing-in-charcot-neuroarthropathy
#11
Khaled M Emara, Ramy Ahmed Diab, Mohamed Amr Hemida
INTRODUCTION: Charcot's neuroarthropathy of ankle leads to instability, destruction of the joint with significant morbidity that may require an amputation. Aim of surgical treatment is to achieve painless stable plantigrade foot through arthrodesis. Achieving surgical arthrodesis in Charcot's neuroarthropathy has a high failure rate. We assess the outcomes of retrograde intramedullary interlocked nailing in tibio-talar arthrodesis for Charcot's neuroarthropathy. MATERIALS AND METHODS: 42 diabetic patients with a mean age of 49 year underwent ankle tibio-talar arthrodesis using retrograde nailing for Charcot's neuroarthropathy...
November 7, 2017: Foot
https://www.readbyqxmd.com/read/29172295/evaluation-of-mir-224-mir-215-and-mir-143-as-serum-biomarkers-for-hcv-associated-hepatocellular-carcinoma
#12
Samah Mamdouh, Fatma Khorshed, Tarek Aboushousha, Hussam Hamdy, Ayman Diab, Mohamed Seleem, Mohamed Saber
HCV induced hepatitis and hepatocellular carcinoma as its sequel are major health problems world-wide and especially in Egypt. For diagnosis and during treatment of liver diseases, liver functions are monitored through determination of serum levels of liver enzymes and α-fetoprotein although the obtained information is generally not sufficient for either early detection of hepatic insult or effective follow up of therapeutic effects. More sensitive biomarkers may help to achieve these goals. MiRNAs are small non-coding RNAs that have an important role in gene expression and regulation...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29170095/assessing-prevalence-of-and-barriers-to-medication-adherence-in-patients-with-uncontrolled-diabetes-attending-primary-healthcare-clinics-in-qatar
#13
Myriam Jaam, Mohamed Izham Mohamed Ibrahim, Nadir Kheir, Muhammad Abdul Hadi, Mohammad Issam Diab, Ahmed Awaisu
BACKGROUND: Studies conducted in Qatar have reported a high prevalence of diabetic nephropathy, retinopathy, and neuropathy. These complications are often associated with poor medication adherence and uncontrolled diabetes. The objectives of this study were to determine the rate of medication adherence among patients with uncontrolled diabetes, and to compare the characteristics and identified barriers between patients with good and those with poor medication adherence. METHOD: A cross-sectional quantitative study was conducted among patients living in Qatar with uncontrolled diabetes attending primary healthcare clinics from October 2016 to January 2017...
November 20, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/29162265/the-impact-of-antegrade-intramedullary-nailing-start-site-using-the-sign-nail-in-proximal-femoral-fractures-a-prospective-cohort-study
#14
Mohamed Mustafa Diab, Hao-Hua Wu, Edmund Eliezer, Billy Haonga, Saam Morshed, David W Shearer
INTRODUCTION: In many low and middle-income countries (LMICs) SIGN nail is commonly used for antegrade femoral intramedullary (IM) nailing, using a start site either at the tip of the greater trochanter or piriformis fossa. While a correct start site is considered an essential technical step; few studies have evaluated the impact of using an erroneous start site. This is particularly relevant in settings with limited access to fluoroscopy to aid in creating a nail entry point. The purpose of this study was to evaluate the impact of antegrade SIGN IM nailing start site on radiographic alignment and health-related quality of life...
November 18, 2017: Injury
https://www.readbyqxmd.com/read/29162153/managing-toxicities-associated-with-immune-checkpoint-inhibitors-consensus-recommendations-from-the-society-for-immunotherapy-of-cancer-sitc-toxicity-management-working-group
#15
I Puzanov, A Diab, K Abdallah, C O Bingham, C Brogdon, R Dadu, L Hamad, S Kim, M E Lacouture, N R LeBoeuf, D Lenihan, C Onofrei, V Shannon, R Sharma, A W Silk, D Skondra, M E Suarez-Almazor, Y Wang, K Wiley, H L Kaufman, M S Ernstoff
Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse events (irAEs). Many of these are driven by the same immunologic mechanisms responsible for the drugs' therapeutic effects, namely blockade of inhibitory mechanisms that suppress the immune system and protect body tissues from an unconstrained acute or chronic immune response...
November 21, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29152725/regressed-melanocytic-nevi-secondary-to-pembrolizumab-therapy-an-emerging-melanocytic-dermatologic-effect-from-immune-checkpoint-antibody-blockade
#16
Shakuntala H Mauzo, Michael T Tetzlaff, Kelly Nelson, Rodabe Amaria, Sapna Patel, Phyu P Aung, Priyadharsini Nagarajan, Carlos A Torres-Cabala, Adi Diab, Victor G Prieto, Jonathan L Curry
BACKGROUND: Immune checkpoint antibody blockade is an emerging therapeutic option for treating certain cancers including melanoma. This therapy is associated with dermatologic and systemic toxicities, some of which are more severe than others and may require withholding therapy. CASE REPORTS: We report two patients with melanocytic nevi that regressed with pembrolizumab therapy. The first patient had stage IV BRAF K601E/L584F mutant melanoma that developed a regressed melanocytic nevus while being treated with pembrolizumab...
November 20, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29132630/evaluating-e-consultation-implementations-based-on-use-and-time-line-across-various-specialties
#17
Pratik J Parikh, Corinne Mowrey, Jennie Gallimore, Stephen Harrell, Brian Burke
BACKGROUND: Electronic Consultation (e-consults) can provide improved access, enhance patient and provider satisfaction, and reduce beneficiary travel expenses. We explored how e-consults were implemented across three specialty areas, diabetes (Diab), gastroenterology (GI), and neurosurgery (Neuro), at two Veterans Affairs hospitals in terms of strategies for use and time-lines. METHODS: We conducted observations and electronically shadowed patient e-consultations submitted to a specialty care service by primary care provider(s) at the two sites during a thirteen-month period...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29129918/intratumoral-cd40-activation-and-checkpoint-blockade-induces-t-cell-mediated-eradication-of-melanoma-in-the-brain
#18
Manisha Singh, Christina Vianden, Mark J Cantwell, Zhimin Dai, Zhilan Xiao, Meenu Sharma, Hiep Khong, Ashvin R Jaiswal, Faisal Faak, Yared Hailemichael, L M E Janssen, Uddalak Bharadwaj, Michael A Curran, Adi Diab, Roland L Bassett, David J Tweardy, Patrick Hwu, Willem W Overwijk
CD40 agonists bind the CD40 molecule on antigen-presenting cells and activate them to prime tumor-specific CD8+ T cell responses. Here, we study the antitumor activity and mechanism of action of a nonreplicating adenovirus encoding a chimeric, membrane-bound CD40 ligand (ISF35). Intratumoral administration of ISF35 in subcutaneous B16 melanomas generates tumor-specific, CD8+ T cells that express PD-1 and suppress tumor growth. Combination therapy of ISF35 with systemic anti-PD-1 generates greater antitumor activity than each respective monotherapy...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29115468/curcumin-alleviates-liver-oxidative-stress-in-type-1-diabetic-rats
#19
Zhenglu Xie, Binbin Wu, Guozhi Shen, Xiaqing Li, Qianying Wu
The aim of the present study was to determine the effects of curcumin on antioxidants using a rat model of type 1 diabetes. Seven‑week‑old male Sprague‑Dawley rats were injected with Streptozotocin (STZ) intraperitoneally to induce this model, and then treated with 1.0% curcumin (weight ratio) mixed in their diet for 21 days. The present study included three groups: Control group (NC), diabetic rat model group (DC) and a curcumin treated group (Diab‑Cur). The results demonstrated that curcumin treatment markedly decreased the blood glucose levels, plasma malondialdehyde concentration and plasma activity of glutathione peroxidase (GSH‑Px) and catalase (CAT); however, it increased the plasma superoxide dismutase (SOD) and insulin levels...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29111097/lipid-nanocarriers-as-skin-drug-delivery-systems-properties-mechanisms-of-skin-interactions-and-medical-applications
#20
REVIEW
M Sala, R Diab, A Elaissari, H Fessi
During the past decades, lipid nanocarriers are gaining momentum with their multiple advantages for the management of skin diseases. Lipid nanocarriers enable to target the therapeutic payload to deep skin layers or even to reach the blood circulation making them a promising cutting-edge technology. Lipid nanocarriers refer to a large panel of drug delivery systems. Lipid vesicles are the most conventional, known to be able to carry lipophilic and hydrophilic active agents. A variety of lipid vesicles with high flexibility and deformability could be obtained by adjusting their composition; namely ethosomes, transfersomes and penetration enhancer lipid vesicles which achieve the best results in term of skin permeation...
October 27, 2017: International Journal of Pharmaceutics
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