Ariki Nagashima, Kenichiro Okimoto, Ryo Nakagawa, Naoki Akizue, Tomoaki Matsumura, Hirotaka Oura, Ryuta Kojima, Chihiro Goto, Satsuki Takahashi, Ryosuke Horio, Akane Kurosugi, Tsubasa Ishikawa, Wataru Shiratori, Tatsuya Kaneko, Kengo Kanayama, Yuki Ohta, Takashi Taida, Keiko Saito, Tetsuhiro Chiba, Jun Kato, Naoya Kato
The mechanism of metachronous recurrence (MR) after performing endoscopic treatment for early gastric adenocarcinoma (GAC) and eradicating Helicobacter pylori (H. pylori) is unknown. To elucidate the mechanism and risk factors of MR, we analyzed gene expression at multiple locations of the gastric mucosa. We selected each five patients with MR and without MR (control), after early GAC treatment and eradication of H. pylori. Mucosal tissue was collected from four sites in the stomach of each patient as biopsy specimens for mRNA sequencing, gene set enrichment analysis, and microRNA (miRNA) sequencing...
November 11, 2023: Scientific Reports