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https://www.readbyqxmd.com/read/29275979/prediction-of-a-multiple-sclerosis-diagnosis-in-patients-with-clinically-isolated-syndrome-using-the-2016-magnims-and-2010-mcdonald-criteria-a-retrospective-study
#1
Massimo Filippi, Paolo Preziosa, Alessandro Meani, Olga Ciccarelli, Sarlota Mesaros, Alex Rovira, Jette Frederiksen, Christian Enzinger, Frederik Barkhof, Claudio Gasperini, Wallace Brownlee, Jelena Drulovic, Xavier Montalban, Stig P Cramer, Alexander Pichler, Marloes Hagens, Serena Ruggieri, Vittorio Martinelli, Katherine Miszkiel, Mar Tintorè, Giancarlo Comi, Iris Dekker, Bernard Uitdehaag, Irena Dujmovic-Basuroski, Maria A Rocca
BACKGROUND: In 2016, the Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) network proposed modifications to the MRI criteria to define dissemination in space (DIS) and time (DIT) for the diagnosis of multiple sclerosis in patients with clinically isolated syndrome (CIS). Changes to the DIS definition included removal of the distinction between symptomatic and asymptomatic lesions, increasing the number of lesions needed to define periventricular involvement to three, combining cortical and juxtacortical lesions, and inclusion of optic nerve evaluation...
December 21, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29238292/effect-of-vegf-on-inflammatory-regulation-neural-survival-and-functional-improvement-in-rats-following-a-complete-spinal-cord-transection
#2
Jing Li, Shuangxi Chen, Zhikai Zhao, Yunhao Luo, Yuhui Hou, Heng Li, Liumin He, Libing Zhou, Wutian Wu
After complete transection of the thoracic spinal segment, neonatal rats exhibit spontaneous locomotor recovery of hindlimbs, but this recovery is not found in adult rats after similar injury. The potential mechanism related to the difference in recovery of neonatal and adult rats remains unknown. In this study, 342 animals were analyzed. The vascular endothelial growth factor (VEGF) level in spinal segments below injury sites was significantly higher in postnatal day 1 rats (P1) compared with 28-day-old adult rats (P28) following a complete T9 transection...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29190704/electrocortical-correlates-of-human-level-ground-slope-and-stair-walking
#3
Trieu Phat Luu, Justin A Brantley, Sho Nakagome, Fangshi Zhu, Jose L Contreras-Vidal
This study investigated electrocortical dynamics of human walking across different unconstrained walking conditions (i.e., level ground (LW), ramp ascent (RA), and stair ascent (SA)). Non-invasive active-electrode scalp electroencephalography (EEG) signals were recorded and a systematic EEG processing method was implemented to reduce artifacts. Source localization combined with independent component analysis and k-means clustering revealed the involvement of four clusters in the brain during the walking tasks: Left and Right Occipital Lobe (LOL, ROL), Posterior Parietal Cortex (PPC), and Central Sensorimotor Cortex (SMC)...
2017: PloS One
https://www.readbyqxmd.com/read/29187551/model-of-a-bilateral-brown-type-central-pattern-generator-for-symmetric-and-asymmetric-locomotion
#4
Anton Sobinov, Sergiy Yakovenko
The coordinated activity of muscles is produced in part by spinal rhythmogenic neural circuits, termed central pattern generators (CPGs). A classical CPG model is a system of coupled oscillators that transform locomotor drive into coordinated and gait-specific patterns of muscle recruitment. The network properties of this conceptual model can be simulated by a system of ordinary differential equations with a physiologically-inspired coupling locus of interactions capturing the timing relationship for bilateral coordination of limbs in locomotion...
November 29, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29180893/identification-of-key-genes-and-pathways-associated-with-neuropathic-pain-in-uninjured-dorsal-root-ganglion-by-using-bioinformatic-analysis
#5
Chao-Jin Chen, De-Zhao Liu, Wei-Feng Yao, Yu Gu, Fei Huang, Zi-Qing Hei, Xiang Li
Purpose: Neuropathic pain is a complex chronic condition occurring post-nervous system damage. The transcriptional reprogramming of injured dorsal root ganglia (DRGs) drives neuropathic pain. However, few comparative analyses using high-throughput platforms have investigated uninjured DRG in neuropathic pain, and potential interactions among differentially expressed genes (DEGs) and pathways were not taken into consideration. The aim of this study was to identify changes in genes and pathways associated with neuropathic pain in uninjured L4 DRG after L5 spinal nerve ligation (SNL) by using bioinformatic analysis...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29164149/bioinformatics-genes-and-pathway-analysis-for-chronic-neuropathic-pain-after-spinal-cord-injury
#6
REVIEW
Guan Zhang, Ping Yang
It is well known spinal cord injury (SCI) can cause chronic neuropathic pain (NP); however its underlying molecular mechanisms remain elusive. This study aimed to disclose differentially expressed genes (DEGs) and activated signaling pathways in association with SCI induced chronic NP, in order to identify its diagnostic and therapeutic targets. Microarray dataset GSE5296 has been downloaded from Gene Expression Omnibus (GEO) database. Significant analysis of microarray (SAM), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and pathway network analysis have been used to compare changes of DEGs and signaling pathways between the SCI and sham-injury group...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29163344/systemic-and-local-cytokine-profile-following-spinal-cord-injury-in-rats-a-multiplex-analysis
#7
Yana O Mukhamedshina, Elvira R Akhmetzyanova, Ekaterina V Martynova, Svetlana F Khaiboullina, Luisa R Galieva, Albert A Rizvanov
Our study of the changes in cytokine profile in blood serum and in the spinal cord after traumatic spinal cord injury (SCI) has shown that an inflammatory reaction and immunological response are not limited to the CNS, but widespread. This fact was confirmed by changes detected in a cytokine profile in blood serum samples [MIP-1α, interleukin 1 (IL-1) α, IL-2, IL-5, IL-1β, MCP-1, RANTES]. There were also changes in the levels of MIP-1α, IL-1α, IL-2, IL-5, IL-18, GM-colony-stimulating factor, IL-17α, IFN-γ, IL-10, IL-13, MCP-1, and GRO KC CINC-1 in samples of the rat injured spinal cord...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29149772/natural-history-of-infantile-onset-spinal-muscular-atrophy
#8
Stephen J Kolb, Christopher S Coffey, Jon W Yankey, Kristin Krosschell, W David Arnold, Seward B Rutkove, Kathryn J Swoboda, Sandra P Reyna, Ai Sakonju, Basil T Darras, Richard Shell, Nancy Kuntz, Diana Castro, Julie Parsons, Anne M Connolly, Claudia A Chiriboga, Craig McDonald, W Bryan Burnette, Klaus Werner, Mathula Thangarajh, Perry B Shieh, Erika Finanger, Merit E Cudkowicz, Michelle M McGovern, D Elizabeth McNeil, Richard Finkel, Susan T Iannaccone, Edward Kaye, Allison Kingsley, Samantha R Renusch, Vicki L McGovern, Xueqian Wang, Phillip G Zaworski, Thomas W Prior, Arthur H M Burghes, Amy Bartlett, John T Kissel
OBJECTIVE: Infantile-onset spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality, typically resulting in death prior to age 2. Clinical trials in this population require an understanding of disease progression and identification of meaningful biomarkers to hasten therapeutic development and predict outcomes. METHODS: A longitudinal, multi-center, prospective natural history study enrolled 26 SMA infants, and 27 control infants less than six months of age...
November 17, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29113156/identification-of-potential-therapeutic-targets-for-gliomas-by-bioinformatics-analysis
#9
Ke Ma, Zhihua Cheng, Liqun Sun, Haibo Li
Gliomas are primary tumors that originate in the brain or spinal cord and develop from supportive glial cells. The present study aimed to identify potential candidate molecular markers for the treatment of gliomas, and to explore the underlying mechanisms of this disease. The gene expression profile data GSE50021, which consisted of 10 specimens of normal brain tissues and 35 specimens of glioma tissues, was downloaded from Gene Expression Omnibus (GEO). The methylation microarray data GSE50022, consisting of 28 glioma specimens, was also downloaded from GEO...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29060180/functional-connectivity-analysis-of-multiplex-muscle-network-across-frequencies
#10
Jennifer N Kerkman, Andreas Daffertshofer, Leonardo L Gollo, Michael Breakspear, Tjeerd W Boonstra
Physiological networks reveal information about the interaction between subsystems of the human body. Here we investigated the interaction between the central nervous system and the musculoskeletal system by mapping functional muscle networks. Muscle networks were extracted using coherence analysis of muscle activity assessed using surface electromyography (EMG). Surface EMG was acquired from 36 muscles distributed throughout the body while participants were standing upright and performing a bimanual pointing task...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29044773/integrated-analysis-of-microrna-and-mrna-expression-profiles-in-the-rat-spinal-cord-under-inflammatory-pain-conditions
#11
Chien Cheng Liu, Jiin Tsuey Cheng, Tien Yui Li, Ping Heng Tan
Recent studies using microarray-based approaches have demonstrated that microRNAs (miRNAs) are involved in pain processing pathways. However, a significant proportion of computational predictions of miRNA targets are false-positive interactions. To increase the chance of identifying biologically relevant targets, we performed an integrated analysis of both miRNA and mRNA expression profiles in the rat spinal cord during complete Freund's adjuvant (CFA)-induced inflammatory pain. We generated miRNA and mRNA arrays from the same corresponding samples on Days 5 and 14 after CFA injection...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29037862/artificial-urinary-sphincter-in-male-patients-with-spina-bifida-comparison-of-perioperative-and-functional-outcomes-between-bulbar-urethra-and-bladder-neck-cuff-placement
#12
Zine-Eddine Khene, Fanny Paret, Marie-Aime E Perrouin-Verbe, Thomas Prudhomme, Juliette Hascoet, Mathilde Nedelec, Jacques Kerdraon, Helene Menard, Magali Jezequel, Loïc Le Normand, Andrea Manunta, Xavier Game, Benoit Peyronnet
PURPOSE: To evaluate the perioperative and long-term functional outcomes of bladder neck and peribulbar cuff placement of an artificial urinary sphincter (AUS) in a population of adult male patients with spinal dysraphism. PATIENTS AND METHODS: A retrospective analysis of the French spina bifida (SB) network database was performed. Patients who underwent implantation of an AUS from January 1985 to November 2015 were selected and stratified into two groups according to cuff location: bladder neck vs...
October 13, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28989002/chi3l1-and-chi3l2-overexpression-in-motor-cortex-and-spinal-cord-of-sals-patients
#13
C Sanfilippo, A Longo, F Lazzara, D Cambria, G Distefano, M Palumbo, A Cantarella, L Malaguarnera, M Di Rosa
BACKGROUND: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disease characterized by the degeneration and death of upper (UMN) and lower (LMN) motor neurons. In the last decade, it has been shown that Chitinases are an important prognostic indicator of neuro-inflammatory damage induced by microglia and astrocytes. MATERIALS AND METHODS: We analyzed microarray datasets obtained from the Array Express in order to verify the expression levels of CHI3L1 and CHI3L2 in motor cortex biopsies of sALS patients with different survival times...
October 6, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28961370/mir-181d-5p-promotes-neurite-outgrowth-in-pc12%C3%A2-cells-via-pi3k-akt-pathway
#14
Li-Ming Shen, Zhi-Wen Song, Yin Hua, Xu Chao, Jin-Bo Liu
INTRODUCTION: miRNAs dysregulate in spinal cord injury (SCI) and have been demonstrated to play a crucial role in neurite outgrowth. However, the underlying mechanism remains elusive. In this study, we constructed a mouse model of SCI, extracted RNA from injured spinal cord tissue for the use of microarray assay. miR-181d-5p which is one of the most significantly expressed miRNAs in miRNA-mRNA network, abundantly expressed in center system and highly conserved across different spices, was chosen for our further study...
September 29, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28926781/a-leukomyeloencephalopathy-of-unknown-origin-in-an-azawakh-dog
#15
Maria Teresa Mandara, Alice Reginato, Federica Balducci, Marco Bernardini
A diffuse bilaterally symmetrical leukomyeloencephalopathy was observed in a 6-year-old male Azawakh dog showing a slowly progressive ataxia of six months duration associated with sensory disorders. Severe bilaterally symmetrical demyelination and vacuolisation were confined to the dorsal columns along the entire spinal cord with a minor axonal degeneration. The main changes of myelin sheaths consisted in splitting and intramyelin vacuolization. Naked axons were scattered in a network of astrocytic processes and collagen fibres...
August 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28899285/predicting-rehabilitation-length-of-stay-in-canada-it-s-not-just-about-impairment
#16
B Catharine Craven, Dilnur Kurban, Farnoosh Farahani, Carly S Rivers, Chester Ho, A Gary Linassi, Dany H Gagnon, Colleen O'Connell, Karen Ethans, Laurent J Bouyer, Vanessa K Noonan
INTRODUCTION: Current tertiary Spinal Cord Injury (SCI) rehabilitation funding and rehabilitation length of stay (R-LOS) in most North American jurisdictions are linked to an individual's impairment. Our objectives were to: 1) describe the impact of relevant demographic, impairment and medical complexity variables at rehabilitation admission on R-LOS among adult Canadians with traumatic SCI; and 2) identify factors which extend R-LOS. METHODS: Data from 1,376 adults with traumatic SCI were obtained via chart abstraction and administrative data linkage from 15 Rick Hansen SCI Registry sites (2004-2014)...
September 12, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28894545/comparing-performances-of-intelligent-classifier-algorithms-for-predicting-type-of-pain-in-patients-with-spinal-cord-injury
#17
Nasrolah Nasr HeidarAbadi, Laleh Hakemi, Pirhossein Kolivand, Reza Safdari, Marjan Ghazi Saeidi
BACKGROUND AND AIM: In this study, performances of classification techniques were compared in order to predict type of pain in patients with spinal cord injury. Pain is one of the main problems in people with spinal cord injury. Identifying the optimal classification technique will help improve decision support systems in clinical settings. METHODS: A descriptive retrospective analysis was performed in 253 patients. We compared performances of "Bayesian Networks", "Decision Tree", neural networks: "Multi-Layer Perceptron" (MLP), and "Support Vector Machines" (SVM)...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28885295/morphometric-analysis-of-rat-spinal-cord-angioarchitecture-by-phase-contrast-radiography-from-2d-to-3d-visualization
#18
Tianding Wu, Yong Cao, Shuangfei Ni, Zixiang Luo, Liyuan Jiang, Hongbin Lu, Jianzhong Hu
STUDY DESIGN: An advanced imaging of vasculature with synchrotron radiation X-ray in a rat model. OBJECTIVE: To develop the potential for quantitative assessment of vessel network from 2D to 3D visualization by synchrotron radiation X-ray phase contrast tomography (XPCT) in rat spinal cord model. SUMMARY OF BACKGROUND DATA: Investigation of microvasculature contributes to the understanding of pathological development of spinal cord injury...
September 6, 2017: Spine
https://www.readbyqxmd.com/read/28874923/noninvasive-brain-stimulation-maladaptive-plasticity-and-bayesian-analysis-in-phantom-limb-pain
#19
REVIEW
Leon Morales-Quezada
Introduction: Phantom limb pain (PLP) is a common and poorly understood pathology of difficult medical control that progressively takes place after amputation occurs. Objective: This article discusses the multifactorial bases of PLP. These bases involve local changes at the stump level, spinal modifications of excitability, deafferentation, and central sensitization, leading to the development of maladaptive plasticity, and consequentially, defective processing of sensory information by associative neural networks...
August 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/28856689/real-time-large-scale-in-vivo-observations-reveal-intrinsic-synchrony-plasticity-and-growth-cone-dynamics-of-midline-crossing-axons-during-neuronal-wiring-of-the-zebrafish-spinal-cord
#20
Søren S L Andersen
How axons are wired in the vertebrate spinal cord has been studied mostly using fixed samples or looking at individually growing axons. Using light-sheet microscopy, early neural development is here followed in vivo in real time at high resolution along several hundred micrometers of the zebrafish spinal cord. The dynamics and time course of cellular development and axonal wiring of interneurons expressing GFP under control of the dmrt3 promotor are analyzed. Following neurulation, commissural axons are observed crossing the ventral floor plate midline perpendicularly at about 20 microns/h and in a manner dependent on the Robo3 but not the EphA4 receptors...
August 30, 2017: Journal of Comparative Neurology
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