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https://www.readbyqxmd.com/read/28187072/predictors-of-blood-transfusion-in-posterior-lumbar-spinal-fusion-a-canadian-spine-outcome-and-research-network-csorn-study
#1
Mina W Morcos, Fan Jiang, Greg McIntosh, Michael Johnson, Sean Christie, Eugene Wai, Jean Ouellet, Chris Bailey, Henry Ahn, Jerome Paquet, Neil Manson, Charles Fisher, Raja Rampersaud, Ken Thomas, Hamilton Hall, Michael Weber
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To identify patient or procedure related predictors of postoperative blood transfusions in posterior lumbar fusion (PSF). SUMMARY OF BACKGROUND DATA: The rate of PSF surgery has increased significantly. It remains the most common surgical procedure used to stabilize the spine; however, the impact of blood loss requiring blood transfusions remains a significant concern. METHODS: Analysis of data from the Canadian Spine Outcomes and Research Network...
February 9, 2017: Spine
https://www.readbyqxmd.com/read/28137972/identification-of-the-upward-movement-of-human-cerebrospinal-fluid-in-vivo-and-its-relation-to-the-brain-venous-system
#2
Steffi Dreha-Kulaczewski, Arun A Joseph, Klaus-Dietmar Merboldt, Hans-Christoph Ludwig, Jutta Gärtner, Jens Frahm
: Cerebrospinal fluid (CSF) flux is involved in the pathophysiology of neurodegenerative diseases and cognitive impairment after traumatic brain injury, all hallmarked by the accumulation of cellular metabolic waste. Its effective disposal via various CSF routes has been demonstrated in animal models. In contrast, the CSF dynamics in humans are still poorly understood. Forced Inspiration has recently been identified as a main driving force of CSF flow in the human brain using novel real-time magnetic resonance imaging (MRI)...
January 30, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28112212/quantitative-3d-investigation-of-neuronal-network-in-mouse-spinal-cord-model
#3
I Bukreeva, G Campi, M Fratini, R Spanò, D Bucci, G Battaglia, F Giove, A Bravin, A Uccelli, C Venturi, M Mastrogiacomo, A Cedola
The investigation of the neuronal network in mouse spinal cord models represents the basis for the research on neurodegenerative diseases. In this framework, the quantitative analysis of the single elements in different districts is a crucial task. However, conventional 3D imaging techniques do not have enough spatial resolution and contrast to allow for a quantitative investigation of the neuronal network. Exploiting the high coherence and the high flux of synchrotron sources, X-ray Phase-Contrast multiscale-Tomography allows for the 3D investigation of the neuronal microanatomy without any aggressive sample preparation or sectioning...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28106101/the-systematic-analysis-of-coding-and-long-non-coding-rnas-in-the-sub-chronic-and-chronic-stages-of-spinal-cord-injury
#4
Raquel Cuevas-Diaz Duran, Han Yan, Yiyan Zheng, Xingfan Huang, Raymond Grill, Dong H Kim, Qilin Cao, Jia Qian Wu
Spinal cord injury (SCI) remains one of the most debilitating neurological disorders and the majority of SCI patients are in the chronic phase. Previous studies of SCI have usually focused on few genes and pathways at a time. In particular, the biological roles of long non-coding RNAs (lncRNAs) have never been characterized in SCI. Our study is the first to comprehensively investigate alterations in the expression of both coding and long non-coding genes in the sub-chronic and chronic stages of SCI using RNA-Sequencing...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093431/which-is-best-for-osteoporotic-vertebral-compression-fractures-balloon-kyphoplasty-percutaneous-vertebroplasty-or-non-surgical-treatment-a-study-protocol-for-a-bayesian-network-meta-analysis
#5
Shun-Li Kan, Zhi-Fang Yuan, Ling-Xiao Chen, Jing-Cheng Sun, Guang-Zhi Ning, Shi-Qing Feng
INTRODUCTION: Osteoporotic vertebral compression fractures (OVCFs) commonly cause both acute and chronic back pain, substantial spinal deformity, functional disability and decreased quality of life and increase the risk of future vertebral fractures and mortality. Percutaneous vertebroplasty (PVP), balloon kyphoplasty (BK) and non-surgical treatment (NST) are mostly used for the treatment of OVCFs. However, which treatment is preferred is unknown. The purpose of this study is to comprehensively review the literature and ascertain the relative efficacy and safety of BK, PVP and NST for patients with OVCFs using a Bayesian network meta-analysis...
January 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28087734/increased-mitophagy-in-the-skeletal-muscle-of-spinal-and-bulbar-muscular-atrophy-patients
#6
Doriana Borgia, Adriana Malena, Marco Spinazzi, Maria Andrea Desbats, Leonardo Salviati, Aaron P Russell, Giovanni Miotto, Laura Tosatto, Elena Pegoraro, Gianni Sorarù, Maria Pennuto, Lodovica Vergani
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disorder caused by polyglutamine expansion in the androgen receptor (AR) and characterized by the loss of lower motor neurons. Here we investigated pathological processes occurring in muscle biopsy specimens derived from SBMA patients and, as controls, age-matched healthy subjects and patients suffering from amyotrophic lateral sclerosis (ALS) and neurogenic atrophy. We detected atrophic fibers in the muscle of SBMA, ALS and neurogenic atrophy patients...
January 13, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28072795/treatment-outcomes-for-patients-with-failed-back-surgery
#7
Jae Hwan Cho, Jae Hyup Lee, Kwang Sup Song, Jae-Young Hong, Yoon-Suk Joo, Dong-Ho Lee, Chang Ju Hwang, Choon Sung Lee
BACKGROUND: Failed back surgery syndrome (FBSS) is a frequently encountered disease entity following lumbar spinal surgery. Although many plausible reasons have been investigated, the exact pathophysiology remains unknown. Various medications, reoperations, interventions such as spinal cord stimulation, epidural adhesiolysis or epidural injection, exercise therapy, and psychotherapy have been suggested treatment options. However, the evidence of the clinical outcome for each treatment has not been clearly determined...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28071686/identification-of-temporal-genes-involved-in-the-mechanisms-of-spinal-cord-injury
#8
S Ma, J Wang, L Liu, L Xia, R Tao
OBJECTIVES: As a high-cost neurological disability, spinal cord injury (SCI) can result in permanent paralysis and loss of sensation. To identify the temporal genes involved in the pathogenesis of SCI, we analysed the expression profile of GSE45006. METHODS: GSE45006 was downloaded from Gene Expression Omnibus, including 20 SCI samples (samples at 1 day, 3 days, 1 week, 2 weeks and 8 weeks after injury, four repetitions for each time point) and 4 normal samples...
January 10, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28068167/vehicle-exposure-and-spinal-musculature-fatigue-in-military-warfighters-a-meta-analysis
#9
REVIEW
Roger O Kollock, Kenneth E Games, Alan E Wilson, JoEllen M Sefton
CONTEXT:  Spinal musculature fatigue from vehicle exposure may place warfighters at risk for spinal injuries and pain. Research on the relationship between vehicle exposure and spinal musculature fatigue is conflicting. A better understanding of the effect of military duty on musculoskeletal function is needed before sports medicine teams can develop injury-prevention programs. OBJECTIVE:  To determine if the literature supports a definite effect of vehicle exposure on spinal musculature fatigue...
November 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/28057537/the-chloride-co-transporters-nkcc1-and-kcc2-in-experimental-autoimmune-encephalomyelitis-eae
#10
Muhammad Saad Yousuf, Kasia Zubkow, Gustavo Tenorio, Bradley Kerr
Patients with multiple sclerosis (MS) often complain of neuropathic pain. According to the Gate Control Theory of Pain, spinal networks of GABAergic inhibitory interneurons are important in modulating nociceptive inputs from the periphery. Na+-K+-2Cl- co-transporter 1 (NKCC1) and K+-Cl- co-transporter 2 (KCC2) generally dictate the tone of GABA/glycine inhibition by regulating intracellular chloride concentrations. In this study, we investigated the role of NKCC1 and KCC2 in neuropathic pain observed in the animal model, experimental autoimmune encephalomyelitis (EAE), a commonly used model to study the pathophysiology of MS...
March 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/28003162/amygdalar-and-hippocampal-connections-with-brainstem-and-spinal-cord-a-diffusion-mri-study-in-human-brain
#11
Alessandro Arrigo, Enricomaria Mormina, Alessandro Calamuneri, Michele Gaeta, Silvia Marino, Demetrio Milardi, Giuseppe Pio Anastasi, Angelo Quartarone
The limbic system has a central role for the integration of several cognitive and visceral functions through an extended network of connections involving the hippocampus and the amygdala. A number of studies performed in humans have been dedicated to the investigation of supratentorial limbic pathways by means of non-invasive MRI approaches, such as DTI. However, detection of possible limbic connections involving the brainstem and the spinal cord is still missing. Subtentorial limbic pathways have been previously studied in animals by means of invasive approaches, including viral tracing...
December 18, 2016: Neuroscience
https://www.readbyqxmd.com/read/28003157/asic-channel-inhibition-enhances-excitotoxic-neuronal-death-in-an-in-vitro-model-of-spinal-cord-injury
#12
Graciela L Mazzone, Priyadharishini Veeraraghavan, Carlota Gonzalez-Inchauspe, Andrea Nistri, Osvaldo D Uchitel
In the spinal cord high extracellular glutamate evokes excitotoxic damage with neuronal loss and severe locomotor impairment. During the cell dysfunction process, extracellular pH becomes acid and may activate acid-sensing ion channels (ASICs) which could be important contributors to neurodegenerative pathologies. Our previous studies have shown that transient application of the glutamate analog kainate (KA) evokes delayed excitotoxic death of spinal neurons, while white matter is mainly spared. The present goal was to enquire if ASIC channels modulated KA damage in relation to locomotor network function and cell death...
December 19, 2016: Neuroscience
https://www.readbyqxmd.com/read/27937140/evaluation-of-whole-brain-resting-state-functional-connectivity-in-spinal-cord-injury-a-large-scale-network-analysis-using-network-based-statistic
#13
Mayank Kaushal, Akinwunmi Oni-Orisan, Gang Chen, Wenjun Li, Jack Leschke, B Douglas Ward, Benjamin Kalinosky, Matthew D Budde, Brian D Schmit, Shi-Jiang Li, Vaishnavi Muqeet, Shekar N Kurpad
Large-scale network analysis characterizes the brain as a complex network of nodes and edges to evaluate functional connectivity patterns. The utility of graph-based techniques has been demonstrated in an increasing number of resting-state functional MRI (rs-fMRI) studies in the normal and diseased brain. However, to our knowledge, graph theory has not been used to study the reorganization pattern of resting-state brain networks in patients with traumatic complete spinal cord injury (SCI). In the present analysis, we applied a graph-theoretical approach to explore changes to global brain network architecture as a result of SCI...
January 27, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27922623/molecular-mechanisms-underlying-the-positive-role-of-treadmill-training-in-locomotor-recovery-after-spinal-cord-injury
#14
Q Liu, B Zhang, C Liu, D Zhao
OBJECTIVES: This study aimed to investigate the molecular mechanisms underlying the positive role of treadmill training (TMT) in locomotor recovery. METHODS: GSE52763 microarray data were downloaded from GEO database, which was collected from the lumbar spinal cord samples of three groups of mice: mice subjected to contusive injury and killed 1 week after injury (I1), mice subjected to injury and killed 3 weeks after injury (I3), and mice subjected to injury and TMT beginning at week 1 and lasting until week 3 (T3)...
December 6, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27903350/-effect-of-lumbar-dorsal-muscle-injuries-on-lumbar-vertebral-bone-quality-of-rat
#15
X P Wang, S J Wang, P Yan, L L Zhu, M Q Li, Z Y Bian, J W Tian
Objective: To explored the effects of lumbar dorsal muscle damage on local lumbar vertebral bone quality. Methods: Thirty SD female rats, at age of 20 weeks, were randomly divided into three groups: control group, or say pseudo surgery group, an incision in the back were performed as CNT; bilateral erector spinal muscle group in which group bilateral lumbar erector spinal muscle were removed as RESM; castration group in which bilateral ovaries were resected as OVX.After three months, bone mineral density, microscopic CT and vertebral compression test were taken in lumbar vertebral (L4-6) in turn...
November 22, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27900462/effects-of-a-trpv1-agonist-capsaicin-on-respiratory-rhythm-generation-in-brainstem-spinal-cord-preparation-from-newborn-rats
#16
Mariho Tani, Sayumi Kotani, Chikara Hayakawa, Shih-Tien Lin, Saki Irie, Keiko Ikeda, Kiyoshi Kawakami, Hiroshi Onimaru
The heat-sensitive transient receptor potential vanilloid 1 (TRPV1) channels are expressed in the peripheral and central nervous systems. However, there is no report on how the activation of TRPV1 causes the modulation of neuronal activity in the medullary respiratory center. We examined effects of capsaicin, a specific agonist of TRPV1 channels, on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats. Capsaicin induced a biphasic response in the respiratory rhythm (a transient decrease followed by an increase in the C4 rate)...
November 29, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27898057/functional-brain-mapping-using-specific-sensory-circuit-stimulation-and-a-theoretical-graph-network-analysis-in-mice-with-neuropathic-allodynia
#17
Yuji Komaki, Keigo Hikishima, Shinsuke Shibata, Tsunehiko Konomi, Fumiko Seki, Masayuki Yamada, Naoyuki Miyasaka, Kanehiro Fujiyoshi, Hirotaka J Okano, Masaya Nakamura, Hideyuki Okano
Allodynia, a form of neuropathic pain, is defined as pain in response to a non-nociceptive stimulus. The brain regions responsible for pain, which are not normally activated, can be activated in allodynic mice by providing a suitable stimulus to Aβ-fibers, which transmit signals from tactile sensory fibers. Functional MRI (fMRI) can be used to objectively observe abnormal brain activation. In the present study, fMRI was conducted to investigate allodynia in mice; allodynia was generated by surgical injury at the L4 spinal nerve root, thus selectively stimulating sensory nerve fibers...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27771730/spatiotemporal-development-of-the-orexinergic-hypocretinergic-system-in-the-central-nervous-system-of-xenopus-laevis
#18
Jesús M López, Lorena Morales, Agustín González
The present immunohistochemical study represents a detailed spatiotemporal analysis of the localization of orexin-immunoreactive (OX-ir) cells and fibers throughout development in the brain of the anuran amphibian Xenopus laevis, a model frequently used in developmental studies. Anurans undergo remarkable physiological changes during the early life stages, and very little is known about the ontogeny and the localization of the centers that control functions such as appetite and feed ingestion in the developing brain...
2016: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/27753790/self-assembling-peptide-reduces-glial-scarring-attenuates-posttraumatic-inflammation-and-promotes-neurite-outgrowth-of-spinal-motor-neurons
#19
Kei Ando, Shiro Imagama, Zenya Ito, Kazuyoshi Kobayashi, Tetsuro Hida, Hiroaki Nakashima, Kenyu Ito, Mikito Tsushima, Yoshimoto Ishikawa, Akiyuki Matsumoto, Koji Nishida, Yoshihiro Nishida, Naoki Ishiguro
STUDY DESIGN: Self-assembling peptide gel (SPG-178) provides new evidence for the role of a scaffold for treatment of the spinal cord through induction of neuroprotective factors. OBJECTIVE: To verify the reproducibility of SPG-178 as scaffold after spinal cord injury, we examine the characteristics of SPG-178 and protective effect on neural cells in vitro and in vivo. SUMMARY OF BACKGROUND DATA: The central nervous system extracellular matrix may play a role in maintenance of the neuronal network by inhibiting axonal growth and suppressing formation of additional inadequate synapses...
October 15, 2016: Spine
https://www.readbyqxmd.com/read/27749628/cervical-spine-injuries-in-children-associated-with-sports-and-recreational-activities
#20
Lynn Babcock, Cody S Olsen, David M Jaffe, Julie C Leonard
OBJECTIVE: The aim of this study was to ascertain potential factors associated with cervical spine injuries in children injured during sports and recreational activities. METHODS: This is a secondary analysis of a multicenter retrospective case-control study involving children younger than 16 years who presented to emergency departments after blunt trauma and underwent cervical spine radiography. Cases had cervical spine injury from sports or recreational activities (n = 179)...
September 30, 2016: Pediatric Emergency Care
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