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https://www.readbyqxmd.com/read/29149772/natural-history-of-infantile-onset-spinal-muscular-atrophy
#1
Stephen J Kolb, Christopher S Coffey, Jon W Yankey, Kristin Krosschell, W David Arnold, Seward B Rutkove, Kathryn J Swoboda, Sandra P Reyna, Ai Sakonju, Basil T Darras, Richard Shell, Nancy Kuntz, Diana Castro, Julie Parsons, Anne M Connolly, Claudia A Chiriboga, Craig McDonald, W Bryan Burnette, Klaus Werner, Mathula Thangarajh, Perry B Shieh, Erika Finanger, Merit E Cudkowicz, Michelle M McGovern, D Elizabeth McNeil, Richard Finkel, Susan T Iannaccone, Edward Kaye, Allison Kingsley, Samantha R Renusch, Vicki L McGovern, Xueqian Wang, Phillip G Zaworski, Thomas W Prior, Arthur H M Burghes, Amy Bartlett, John T Kissel
OBJECTIVE: Infantile-onset spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality, typically resulting in death prior to age 2. Clinical trials in this population require an understanding of disease progression and identification of meaningful biomarkers to hasten therapeutic development and predict outcomes. METHODS: A longitudinal, multi-center, prospective natural history study enrolled 26 SMA infants, and 27 control infants less than six months of age...
November 17, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29113156/identification-of-potential-therapeutic-targets-for-gliomas-by-bioinformatics-analysis
#2
Ke Ma, Zhihua Cheng, Liqun Sun, Haibo Li
Gliomas are primary tumors that originate in the brain or spinal cord and develop from supportive glial cells. The present study aimed to identify potential candidate molecular markers for the treatment of gliomas, and to explore the underlying mechanisms of this disease. The gene expression profile data GSE50021, which consisted of 10 specimens of normal brain tissues and 35 specimens of glioma tissues, was downloaded from Gene Expression Omnibus (GEO). The methylation microarray data GSE50022, consisting of 28 glioma specimens, was also downloaded from GEO...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29060180/functional-connectivity-analysis-of-multiplex-muscle-network-across-frequencies
#3
Jennifer N Kerkman, Andreas Daffertshofer, Leonardo L Gollo, Michael Breakspear, Tjeerd W Boonstra
Physiological networks reveal information about the interaction between subsystems of the human body. Here we investigated the interaction between the central nervous system and the musculoskeletal system by mapping functional muscle networks. Muscle networks were extracted using coherence analysis of muscle activity assessed using surface electromyography (EMG). Surface EMG was acquired from 36 muscles distributed throughout the body while participants were standing upright and performing a bimanual pointing task...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29044773/integrated-analysis-of-microrna-and-mrna-expression-profiles-in-the-rat-spinal-cord-under-inflammatory-pain-conditions
#4
Chien Cheng Liu, Jiin Tsuey Cheng, Tien Yui Li, Ping Heng Tan
Recent studies using microarray-based approaches have demonstrated that microRNAs (miRNAs) are involved in pain processing pathways. However, a significant proportion of computational predictions of miRNA targets are false-positive interactions. To increase the chance of identifying biologically relevant targets, we performed an integrated analysis of both miRNA and mRNA expression profiles in the rat spinal cord during complete Freund's adjuvant (CFA)-induced inflammatory pain. We generated miRNA and mRNA arrays from the same corresponding samples on Days 5 and 14 after CFA injection...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29037862/artificial-urinary-sphincter-in-male-patients-with-spina-bifida-comparison-of-perioperative-and-functional-outcomes-between-bulbar-urethra-and-bladder-neck-cuff-placement
#5
Zine-Eddine Khene, Fanny Paret, Marie-Aime E Perrouin-Verbe, Thomas Prudhomme, Juliette Hascoet, Mathilde Nedelec, Jacques Kerdraon, Helene Menard, Magali Jezequel, Loïc Le Normand, Andrea Manunta, Xavier Game, Benoit Peyronnet
PURPOSE: To evaluate the perioperative and long-term functional outcomes of bladder neck and peribulbar cuff placement of an artificial urinary sphincter (AUS) in a population of adult male patients with spinal dysraphism. PATIENTS AND METHODS: A retrospective analysis of the French spina bifida (SB) network database was performed. Patients who underwent implantation of an AUS from January 1985 to November 2015 were selected and stratified into two groups according to cuff location: bladder neck vs...
October 13, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28989002/chi3l1-and-chi3l2-overexpression-in-motor-cortex-and-spinal-cord-of-sals-patients
#6
C Sanfilippo, A Longo, F Lazzara, D Cambria, G Distefano, M Palumbo, A Cantarella, L Malaguarnera, M Di Rosa
BACKGROUND: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disease characterized by the degeneration and death of upper (UMN) and lower (LMN) motor neurons. In the last decade, it has been shown that Chitinases are an important prognostic indicator of neuro-inflammatory damage induced by microglia and astrocytes. MATERIALS AND METHODS: We analyzed microarray datasets obtained from the Array Express in order to verify the expression levels of CHI3L1 and CHI3L2 in motor cortex biopsies of sALS patients with different survival times...
October 6, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28961370/mir-181d-5p-promotes-neurite-outgrowth-in-pc12%C3%A2-cells-via-pi3k-akt-pathway
#7
Li-Ming Shen, Zhi-Wen Song, Yin Hua, Xu Chao, Jin-Bo Liu
INTRODUCTION: miRNAs dysregulate in spinal cord injury (SCI) and have been demonstrated to play a crucial role in neurite outgrowth. However, the underlying mechanism remains elusive. In this study, we constructed a mouse model of SCI, extracted RNA from injured spinal cord tissue for the use of microarray assay. miR-181d-5p which is one of the most significantly expressed miRNAs in miRNA-mRNA network, abundantly expressed in center system and highly conserved across different spices, was chosen for our further study...
September 29, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28926781/a-leukomyeloencephalopathy-of-unknown-origin-in-an-azawakh-dog
#8
Maria Teresa Mandara, Alice Reginato, Federica Balducci, Marco Bernardini
A diffuse bilaterally symmetrical leukomyeloencephalopathy was observed in a 6-year-old male Azawakh dog showing a slowly progressive ataxia of six months duration associated with sensory disorders. Severe bilaterally symmetrical demyelination and vacuolisation were confined to the dorsal columns along the entire spinal cord with a minor axonal degeneration. The main changes of myelin sheaths consisted in splitting and intramyelin vacuolization. Naked axons were scattered in a network of astrocytic processes and collagen fibres...
August 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28899285/predicting-rehabilitation-length-of-stay-in-canada-it-s-not-just-about-impairment
#9
B Catharine Craven, Dilnur Kurban, Farnoosh Farahani, Carly S Rivers, Chester Ho, A Gary Linassi, Dany H Gagnon, Colleen O'Connell, Karen Ethans, Laurent J Bouyer, Vanessa K Noonan
INTRODUCTION: Current tertiary Spinal Cord Injury (SCI) rehabilitation funding and rehabilitation length of stay (R-LOS) in most North American jurisdictions are linked to an individual's impairment. Our objectives were to: 1) describe the impact of relevant demographic, impairment and medical complexity variables at rehabilitation admission on R-LOS among adult Canadians with traumatic SCI; and 2) identify factors which extend R-LOS. METHODS: Data from 1,376 adults with traumatic SCI were obtained via chart abstraction and administrative data linkage from 15 Rick Hansen SCI Registry sites (2004-2014)...
September 12, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28894545/comparing-performances-of-intelligent-classifier-algorithms-for-predicting-type-of-pain-in-patients-with-spinal-cord-injury
#10
Nasrolah Nasr HeidarAbadi, Laleh Hakemi, Pirhossein Kolivand, Reza Safdari, Marjan Ghazi Saeidi
BACKGROUND AND AIM: In this study, performances of classification techniques were compared in order to predict type of pain in patients with spinal cord injury. Pain is one of the main problems in people with spinal cord injury. Identifying the optimal classification technique will help improve decision support systems in clinical settings. METHODS: A descriptive retrospective analysis was performed in 253 patients. We compared performances of "Bayesian Networks", "Decision Tree", neural networks: "Multi-Layer Perceptron" (MLP), and "Support Vector Machines" (SVM)...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28885295/morphometric-analysis-of-rat-spinal-cord-angioarchitecture-by-phase-contrast-radiography-from-2d-to-3d-visualization
#11
Tianding Wu, Yong Cao, Shuangfei Ni, Zixiang Luo, Liyuan Jiang, Hongbin Lu, Jianzhong Hu
STUDY DESIGN: An advanced imaging of vasculature with synchrotron radiation X-ray in a rat model. OBJECTIVE: To develop the potential for quantitative assessment of vessel network from 2D to 3D visualization by synchrotron radiation X-ray phase contrast tomography (XPCT) in rat spinal cord model. SUMMARY OF BACKGROUND DATA: Investigation of microvasculature contributes to the understanding of pathological development of spinal cord injury...
September 6, 2017: Spine
https://www.readbyqxmd.com/read/28874923/noninvasive-brain-stimulation-maladaptive-plasticity-and-bayesian-analysis-in-phantom-limb-pain
#12
REVIEW
Leon Morales-Quezada
Introduction: Phantom limb pain (PLP) is a common and poorly understood pathology of difficult medical control that progressively takes place after amputation occurs. Objective: This article discusses the multifactorial bases of PLP. These bases involve local changes at the stump level, spinal modifications of excitability, deafferentation, and central sensitization, leading to the development of maladaptive plasticity, and consequentially, defective processing of sensory information by associative neural networks...
August 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/28856689/real-time-large-scale-in-vivo-observations-reveal-intrinsic-synchrony-plasticity-and-growth-cone-dynamics-of-midline-crossing-axons-during-neuronal-wiring-of-the-zebrafish-spinal-cord
#13
Søren S L Andersen
How axons are wired in the vertebrate spinal cord has been studied mostly using fixed samples or looking at individually growing axons. Using light-sheet microscopy, early neural development is here followed in vivo in real time at high resolution along several hundred micrometers of the zebrafish spinal cord. The dynamics and time course of cellular development and axonal wiring of interneurons expressing GFP under control of the dmrt3 promotor are analyzed. Following neurulation, commissural axons are observed crossing the ventral floor plate midline perpendicularly at about 20 microns/h and in a manner dependent on the Robo3 but not the EphA4 receptors...
August 30, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28844009/anatomical-and-electrophysiological-characterization-of-a-population-of-di6-interneurons-in-the-neonatal-mouse-spinal-cord
#14
Anna Griener, Wei Zhang, Henry Kao, Farhia Haque, Simon Gosgnach
The locomotor central pattern generator is a neural network located in the ventral aspect of the caudal spinal cord that underlies stepping in mammals. While many genetically defined interneurons that are thought to comprise this neural network have been identified and characterized, the dI6 cells- which express the transcription factors WT1 and/or DMRT3- are one population that settle in this region, are active during locomotion, whose function is poorly understood. These cells were originally hypothesized to be commissural premotor interneurons, however evidence in support of this is sparse...
August 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28835181/determinants-of-participating-in-life-after-spinal-cord-injury-advice-for-health-professionals-arising-from-an-examination-of-shared-narratives
#15
Delena Amsters, James Duncan, Victoria Field, Alastair Smales, Leanne Zillmann, Melissa Kendall, Pim Kuipers
PURPOSE: To explore the perceived determinants of participation in life after spinal cord injury and incorporate these into a framework for the promotion of participation suitable for use by rehabilitation professionals. METHOD: Four people with spinal cord injury and one health service researcher engaged in a process of sharing narratives of life after spinal cord injury over a period of one year. The narratives were distilled using thematic analysis. RESULTS: The relevant subset of data from the narratives categorized as This is what we think determines our participation in life was analyzed in depth to reveal nine themes (1) The world can be my friend or foe; (2) I am who I am; (3) It is a personal journey; (4) Some like to talk, others like to do; (5) We have the technology; (6) A support network is vital and it can be built; (7) Life involves tradeoffs; (8) Push; and (9) Be flexible...
August 23, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28833372/axonal-components-of-nerves-innervating-the-human-arm
#16
Bernhard Gesslbauer, Laura A Hruby, Aidan D Roche, Dario Farina, Roland Blumer, Oskar C Aszmann
OBJECTIVE: Axons traveling within the brachial plexus are responsible for the dexterous control of human arm and hand movements. Despite comprehensive knowledge on the topographical anatomy of nerves innervating the human upper limbs, the definite quantity of sensory and motor axons within this neural network remains elusive. Our aim was to perform a quantitative analysis of the axonal components of human upper limb nerves based on highly specific molecular features from spinal cord level to the terminal nerves at wrist level...
September 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28816231/molecular-mechanisms-of-the-analgesic-action-of-wu-tou-decoction-on-neuropathic-pain-in-mice-revealed-using-microarray-and-network-analysis
#17
Yan-Qiong Zhang, Chao Wang, Qiu-Yan Guo, Chun-Yan Zhu, Chen Yan, Dan-Ni Sun, Qiong-Hong Xu, Na Lin
Wu-tou Decoction (WTD) is a classic herbal formula in traditional Chinese medicine for the treatment of joint diseases, neuropathic pain (NP) and inflammatory pain. In this study we investigated whether WTD produced analgesic action in a mouse spinal nerve ligation (SNL) model and elucidated the underlying molecular mechanisms. Mice were subjected to SNL and orally treated with WTD (3.15, 6.30 or 12.60 g·kg(-1)·d(-1)) for 21 d. SNL induced mechanical hyperalgesia and heat hyperalgesia characterized by rapid and persistent pain hypersensitivity...
August 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28782683/unidirectional-brain-to-muscle-connectivity-reveals-motor-cortex-control-of-leg-muscles-during-stereotyped-walking
#18
Fiorenzo Artoni, Chiara Fanciullacci, Federica Bertolucci, Alessandro Panarese, Scott Makeig, Silvestro Micera, Carmelo Chisari
In lower mammals, locomotion seems to be mainly regulated by subcortical and spinal networks. On the contrary, recent evidence suggests that in humans the motor cortex is also significantly engaged during complex locomotion tasks. However, a detailed understanding of cortical contribution to locomotion is still lacking especially during stereotyped activities. Here, we show that cortical motor areas finely control leg muscle activation during treadmill stereotyped walking. Using a novel technique based on a combination of Reliable Independent Component Analysis, source localization and effective connectivity, and by combining electroencephalographic (EEG) and electromyographic (EMG) recordings in able-bodied adults we were able to examine for the first time cortical activation patterns and cortico-muscular connectivity including information flow direction...
August 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28768105/exhaled-breath-markers-for-nonimaging-and-noninvasive-measures-for-detection-of-multiple-sclerosis
#19
Yoav Y Broza, Lior Har-Shai, Raneen Jeries, John C Cancilla, Lea Glass-Marmor, Izabella Lejbkowicz, José S Torrecilla, Xuelin Yao, Xinliang Feng, Akimitsu Narita, Klaus Müllen, Ariel Miller, Hossam Haick
Multiple sclerosis (MS) is the most common chronic neurological disease affecting young adults. MS diagnosis is based on clinical characteristics and confirmed by examination of the cerebrospinal fluids (CSF) or by magnetic resonance imaging (MRI) of the brain or spinal cord or both. However, neither of the current diagnostic procedures are adequate as a routine tool to determine disease state. Thus, diagnostic biomarkers are needed. In the current study, a novel approach that could meet these expectations is presented...
August 16, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28761373/chronic-constriction-injury-of-sciatic-nerve-changes-circular-rna-expression-in-rat-spinal-dorsal-horn
#20
Song Cao, Wenwen Deng, Ying Li, Bangyong Qin, Lin Zhang, Shouyang Yu, Peng Xie, Zhi Xiao, Tian Yu
BACKGROUND: Mechanisms of neuropathic pain are still largely unknown. Molecular changes in spinal dorsal horn may contribute to the initiation and development of neuropathic pain. Circular RNAs (circRNAs) have been identified as microRNA sponges and involved in various biological processes, but whether their expression profile changes in neuropathic pain condition is not reported. METHODS: To test whether neuropathic pain influences circRNA expression, we developed a sciatic chronic constriction injury (CCI) model in rats...
2017: Journal of Pain Research
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