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https://www.readbyqxmd.com/read/29925044/a-systematic-review-of-patient-reported-outcomes-in-phase-ii-or-iii-clinical-trials-of-myelodysplastic-syndromes-and-acute-myeloid-leukemia
#1
REVIEW
Ashley Leak Bryant, Sarah W Drier, Sejin Lee, Antonia V Bennett
The purpose of this systematic literature review was to identify clinical trials of MDS and AML that included patient-reported outcome (PRO) instruments, and to summarize the symptom and other health related quality of life (HRQOL) concepts most frequently assessed and the PRO instruments that were used. Sixteen manuscripts describing 14 distinct trials met all criteria (i.e., phase 2 or 3 clinical trial for MDS or AML which included PRO assessment) and were published between 1996-2017. In trials evaluating anemia, PRO scores showed significant improvement in relevant domains (e...
June 7, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29924668/effect-of-fitbit-and-ipad-wearable-technology-in-health-related-quality-of-life-in-adolescent-and-young-adult-cancer-patients
#2
Ilana R Yurkiewicz, Pamela Simon, Michaela Liedtke, Gary Dahl, Tamara Dunn
PURPOSE: Adolescent and young adult (AYA) patients with cancer face significant challenges with regard to fatigue, reduced physical activity, and social isolation, which may negatively impact quality of life. This study investigated whether the use of digital wearable technology (Fitbits, along with synced iPads) can affect health-related quality of life (HRQOL) in AYA aged patients with cancer. MATERIALS AND METHODS: This was a prospective cohort study that offered Fitbits and iPads to all AYA patients aged 15 to 29 at an academic medical center at the time of cancer diagnosis...
June 20, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29923978/correlations-between-health-promoting-lifestyle-and-health-related-quality-of-life-among-elderly-people-with-hypertension-in-hengyang-hunan-china
#3
Jianzhi Li, Jiangdong Yu, Xi Chen, Xuewen Quan, Lan Zhou
Hypertension is considered as an important public health problem in developed and developing countries. The disease is closely associated with health-promoting lifestyle (HPL), and it seems that HPL plays an important role in improving health-related quality of life (HRQOL). This cross-sectional study is to investigate the effects of health-promoting lifestyle (HPL) on health-related quality of life in elderly people with hypertension from a community health service center in Hengyang, Hunan, PR China.Totally 530 elderly patients with hypertension from the community health service center were included in this study, who were asked to fill in a questionnaire (504 patients responded)...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29922914/association-between-quality-of-life-and-clinical-characteristics-in-patients-with-morphea
#4
G Bali, S Kárpáti, M Sárdy, V Brodszky, B Hidvégi, F Rencz
BACKGROUND: Morphea can lead to considerable cosmetic or functional impairment; nevertheless, health-related quality of life (HRQoL) is rarely documented in adult morphea patients. OBJECTIVE: To investigate the impact of morphea on HRQoL and to identify determinants of impaired HRQoL. METHODS: A cross-sectional study has been carried out among adult morphea patients. HRQoL was evaluated by the Dermatology Life Quality Index (DLQI). The modified Localised Scleroderma Skin Severity Index (mLoSSI) and the Localised Scleroderma Damage Index (LoSDI) were applied to evaluate disease activity and damage, respectively...
June 19, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29921556/treatment-related-and-health-related-quality-of-life-in-lipoprotein-apheresis-patients
#5
V De Gucht, K Cromm, A Vogt, U Julius, B Hohenstein, R M Spitthöver, W Ramlow, V J J Schettler, S Maes
BACKGROUND: There is evidence for beneficial effects of lipoprotein apheresis (LA) in terms of reduction of cardiovascular events and interventions, but quality of life (QOL) in LA patients has only been explored in small samples. OBJECTIVE: In this study, both LA- or treatment-related and health-related QOL (HRQOL) were assessed in 206 LA patients. METHODS: Mental and physical HRQOL of the LA patients was assessed by means of the SF-12 as well as the EQ-5D...
May 26, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29920389/long-term-minimum-clinically-important-difference-mcid-in-health-related-quality-of-life-scores-after-instrumented-lumbar-interbody-fusion-for-low-grade-isthmic-spondylolisthesis
#6
Ju-Wan Seuk, Junseok Bae, Sang-Ho Lee, Sang-Ha Shin, Ho Jin Kim
BACKGROUND: Even with its growing popularity, there weren't any comparative studies that explored MCID of HRQoLs following LIF performed on a single-level adult LGIS. OBJECTIVE: The purpose of this study is to investigate factors related to MCID of HRQoLs following instrumented LIF performed on a single-level adult LGIS. METHODS: Consecutive patients who underwent instrumented LIF for single-level LGIS were reviewed. The inclusion criteria were : adult patients who underwent L4-5 or L5-S1, ALIF or TLIF with a posterior screw fixation, and had a minimum 36-month post-operative follow-up period...
June 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29917225/psychological-treatments-for-adults-and-children-with-epilepsy-evidence-based-recommendations-by-the-international-league-against-epilepsy-psychology-task-force
#7
Rosa Michaelis, Venus Tang, Laura H Goldstein, Markus Reuber, William Curt LaFrance, Tobias Lundgren, Avani C Modi, Janelle L Wagner
Given the significant impact that psychosocial factors and epilepsy treatments can have on the health-related quality of life (HRQOL) of individuals with epilepsy and their families, there is great clinical interest in the role of psychological evaluation and treatments to improve HRQOL and comorbidities. Therefore, the International League Against Epilepsy (ILAE) charged the Psychology Task Force with the development of recommendations for clinical care based on evaluation of the evidence from their recent Cochrane review of psychological treatments in individuals with epilepsy...
June 19, 2018: Epilepsia
https://www.readbyqxmd.com/read/29916842/understanding-survivors-needs-and-outcomes-the-role-of-routinely-collected-data
#8
Liya Lu, Jennifer Deane, Linda Sharp
PURPOSE OF REVIEW: The number of cancer survivors is growing due to population ageing, earlier detection and more effective therapies. Routinely collected data (RCD), generally cancer registry data, has been used to investigate survivors' needs and outcomes. We reviewed uses of RCD since 2017, identifying novel findings and research directions. RECENT FINDINGS: Survival is improving internationally but continues to vary between subgroups. Longitudinal survivor surveys suggest malignancy-specific temporal patterns in unmet needs and health-related quality-of-life (HRQoL)...
June 18, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29916266/quality-of-life-and-its-association-with-treatment-satisfaction-adherence-to-medication-and-trust-in-physician-among-patients-with-hypertension-a-cross-sectional-designed-study
#9
Siba Jneid, Hicham Jabbour, Aline Hajj, Antoine Sarkis, Hady Licha, Souheil Hallit, Lydia Rabbaa Khabbaz
OBJECTIVE: Patients with hypertension tend to have a lower health-related quality of life (HRQOL) compared to normotensive patients. This study's main objectives are to assess (1) HRQOL and factors that might impact it and (2) association between HRQOL and adherence to treatment, trust in physician, and treatment satisfaction among patients with hypertension. METHODS: A cross-sectional study enrolled 196 patients from medical-care offices in Beirut, North and South Lebanon...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29915938/-state-of-the-art-of-quality-of-life-measurement-in-patients-with-chronic-otitis-media-and-conductive-hearing-loss
#10
REVIEW
S Lailach, I Baumann, T Zahnert, M Neudert
The evaluation of results after middle ear reconstruction has been mainly based on functional parameters. In clinical practice as well as in otological research, the pure tone audiogram represents the gold standard in the assessment of the postoperative outcome. In order to assess the patient's subjective outcome, outcome analyzes focus increasingly on the health-related quality of life (HRQOL). However, the evaluation of HRQOL requires reliable and validated measuring instruments. A modest number of validated questionnaires for determination of the disease-specific HRQOL in patients with chronic otitis media and/or conductive hearing loss are currently available...
June 18, 2018: HNO
https://www.readbyqxmd.com/read/29914521/the-prognostic-value-of-pain-catastrophizing-in-health-related-quality-of-life-judgments-after-total-knee-arthroplasty
#11
Esther Yakobov, William Stanish, Michael Tanzer, Michael Dunbar, Glen Richardson, Michael J L Sullivan
BACKGROUND: Total knee arthroplasty (TKA) is a highly effective procedure that yields reductions in pain and disability associated with end stage osteoarthritis (OA) of the knee. Quality of life instruments are frequently used to gauge the outcomes of total knee arthroplasty (TKA). However, research suggests that post-TKA reductions in symptom severity may not be the sole predictors of quality of life post-TKA. The primary objective of the present study was to examine the prognostic value of catastrophic thinking in health-related quality of life (HRQoL) judgments in patients with severe OA after TKA...
June 18, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29914500/danish-translation-and-pilot-testing-of-the-european-organization-for-research-and-treatment-of-cancer-qlq-tc-26-eortc-qlq-tc26-questionnaire-to-assess-health-related-quality-of-life-in-patients-with-testicular-cancer
#12
Louise Bager, Abbey Elsbernd, Aase Nissen, Gedske Daugaard, Helle Pappot
BACKGROUND: The European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 is a core questionnaire designed to evaluate health-related quality of life (HRQoL) of cancer patients participating in international clinical trials. It is available in several languages including Danish. The EORTC QLQ-TC26 is a supplemental module developed for patients with testicular cancer, which can be useful in clinical trials. Despite Denmark holding a high prevalence and incidence of testicular cancer, no Danish translation was previously available...
June 18, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29914389/item-distribution-and-inter-rater-reliability-of-the-german-version-of-the-quality-of-life-in-alzheimer-s-disease-scale-qol-ad-proxy-for-people-with-dementia-living-in-nursing-homes
#13
Martin Nikolaus Dichter, Eva-Maria Wolschon, Christian G G Schwab, Gabriele Meyer, Sascha Köpke
BACKGROUND: The Quality of Life in Alzheimer's disease scale (QoL-AD) is a widely used Health Related Quality of Life (HRQoL) instrument. However, studies investigating the instrument's inter-rater reliability (IRR) are missing. This study aimed to determine the item distribution and IRR of the German proxy version of the QoL-AD (13 Items) and a nursing home-specific instrument version (QoL-AD NH, 15 Items). METHODS: The instruments were applied to 73 people with dementia living in eight nursing homes in Germany...
June 19, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29913864/multidisciplinary-pain-treatment-which-patients-do-benefit
#14
Tarja Heiskanen, Risto P Roine, Eija Kalso
Background The prevalence of chronic non-malignant pain in developed countries is high, ranging from 14% to 50%. Patients with chronic pain are active users of health-care services and they report impaired health-related quality of life (HRQoL) when compared with the general population. Psychological distress has been identified as one of the risk factors for pain chronicity. Depression, anxiety and negative beliefs are associated with pain interference and perceived disability. Multidisciplinary pain management (MPM) aims to rehabilitating chronic pain patients by addressing both physical, psychological, social and occupational factors related to the pain problem...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913789/is-health-related-quality-of-life-related-to-the-pattern-of-chronic-pain
#15
Thorbjörg Jonsdottir, Helga Jonsdottir, Sigridur Gunnarsdottir
Background/aims When studying chronic pain in the general population, other factors besides prevalence may be equally important to establish the scope of the problem. Health related quality of life (HRQoL) is an important indicator for how chronic pain influences and interferes with the individual's daily life. The relationships between different characteristics in the nature of pain and HRQoL have been investigated, showing number of pain locations and pain severity to be important. However, little is known about the relationship between pattern of chronic pain (constant/intermittent) and impact on HRQoL...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913663/association-of-modic-changes-with-health-related-quality-of-life-among-patients-referred-to-spine-surgery
#16
Juhani Määttä, Hannu Kautiainen, Ville Leinonen, Jaakko Niinimäki, Salme Järvenpää, Tatu Koskelainen, Pirkka Mäkelä, Juha Pesälä, Timo Nyyssönen, Sakari Savolainen, Olavi Airaksinen, Eero Kyllönen, Kenneth M C Cheung, Jaro Karppinen
Background and purpose Modic changes (MC) are bone marrow and vertebral endplate lesions seen in magnetic resonance imaging (MRI) which have been found to be associated with low back pain (LBP), but the association between MC and health-related quality of life (HRQoL) is poorly understood. The aim of this study was to assess the relationship between MC and HRQoL among patients referred to spine surgery. Methods The study population consisted of 181 patients referred to lumbar spine surgery in Northern and Eastern Finland between June 2007 and January 2011...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913638/health-care-utilization-in-chronic-pain-a-population-based-study
#17
Thorbjörg Jonsdottir, Helga Jonsdottir, Sigridur Gunnarsdottir, Eirikur Lindal
Aims To investigate health care utilization in relation to chronic pain. Methods In this cross-sectional study postal questionnaires, measuring sociodemographic characteristics, pain, health related quality of life (HRQoL), attitudes to pain and health care utilization past six months, were sent to 4500 individuals aged 20-70 years, randomly drawn from the Icelandic National Registry. Results Total response rate was 36.9% (n = 1589) and was higher among older individuals and women. Nearly one half of respondents (47...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913622/why-does-the-impact-of-multidisciplinary-pain-management-on-quality-of-life-differ-so-much-between-chronic-pain-patients
#18
P Vartiainen, T Heiskanen, R P Roine, E Kalso
Aims To assess the change in quality of life and factors predicting this change in 1425 chronic pain patients treated in a multidisciplinary pain clinic. Methods This is an observational follow-up study using the 15D generic health-related quality of life (HRQoL) instrument. Patients filled in the HRQoL questionnaire at baseline, and 6 and 12 months after discharge. To assess if mental factors predicted treatment success, the changes in the overall 15D score were compared and related to the baseline variables of depression and distress...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913138/the-effect-of-thiazide-and-potassium-citrate-use-on-the-health-related-quality-of-life-of-patients-with-urolithiasis
#19
Eric P Raffin, Kristina L Penniston, Jodi A Antonelli, Davis P Viprakasit, Timothy D Averch, Vincent G Bird, Ben H Chew, Sri Sivalingam, Roger L Sur, Stephen Y Nakada, Vernon M Pais
INTRODUCTION: It is unknown whether benefits of medical management of urolithiasis outweigh potential side effects of utilized medications including potassium citrate (Kcit) and thiazide diuretics. Therefore, we sought to evaluate the relationship between Kcit or thiazides and overall stone-related health related quality of life (HRQOL). METHODS: Using cross-sectional data from stone forming enrollees in the North American Stone Quality of Life Consortium, we used the Wisconsin Stone Quality of Life questionnaire (WISQOL) to compare HRQOL between patients treated and not treated with Kcit or thiazide type diuretics...
June 15, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29912978/mediterranean-diet-and-quality-of-life-baseline-cross-sectional-analysis-of-the-predimed-plus-trial
#20
Iñigo Galilea-Zabalza, Pilar Buil-Cosiales, Jordi Salas-Salvadó, Estefanía Toledo, Carolina Ortega-Azorín, Javier Díez-Espino, Zenaida Vázquez-Ruiz, María Dolores Zomeño, Jesús Vioque, José Alfredo Martínez, Dora Romaguera, Napoleón Perez-Farinos, José López-Miranda, Ramón Estruch, Aurora Bueno-Cavanillas, Fernando Arós, Josep Antoni Tur, Francisco Tinahones, Lluis Serra-Majem, Alba Marcos-Delgado, Manuel Ortega-Calvo, Clotilde Vázquez, Xavier Pintó, Josep Vidal, Lidia Daimiel, Miguel Delgado-Rodríguez, Pilar Matía, Dolores Corella, Andrés Diaz-López, Nancy Babio, Miguel Angel Muñoz, Montse Fitó, Sandra González-Palacios, Itziar Abete, Antonio García-Rios, Emilio Ros, Miguel Ángel Martínez-González
We assessed if a 17-item score capturing adherence to a traditional Mediterranean diet (MedDiet) was associated with better health-related quality of life among older Spanish men and women with overweight or obesity harboring the metabolic syndrome. We analyzed baseline data from 6430 men and women (age 55-70 years) participating in the PREDIMED-Plus study. PREDIMED-Plus is a multi-centre randomized trial testing an energy-restricted MedDiet combined with promotion of physical activity and behavioral therapy for primary cardiovascular prevention compared to a MedDiet alone...
2018: PloS One
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