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https://www.readbyqxmd.com/read/27815743/presence-of-a-fellowship-improves-perioperative-outcomes-following-hepatopancreatobiliary-procedures
#1
Maria S Altieri, Jie Yang, Donglei Yin, Catherine Frenkel, Mark Talamini, Dana A Telem, Aurora Pryor
INTRODUCTION: There is an increase in subspecialization and in the number of surgeons seeking fellowship training in the USA. Little is known regarding the effect of hepatopancreatobiliary (HPB) fellowship programs' status of an institution on perioperative outcomes. This study aims to examine the effect of such status on perioperative outcomes across all institutions following complex surgeries involving HPB procedures in the State of New York (NYS). METHODS: The Statewide Planning and Research Cooperative System administrative database was used to identify several complex surgeries involving the pancreas, liver, and gallbladder by using ICD-9 codes for inpatient procedures between 2012 and 2014...
November 4, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27770111/correction-sunitinib-prevents-cachexia-and-prolongs-survival-of-mice-bearing-renal-cancer-by-restraining-stat3-and-murf-1-activation-in-muscle
#2
Francesca Pretto, Carmen Ghilardi, Michele Moschetta, Andrea Bassi, Alessandra Rovida, Valentina Scarlato, Laura Talamini, Fabio Fiordaliso, Cinzia Bisighini, Giovanna Damia, Maria Rosa Bani, Rosanna Piccirillo, Raffaella Giavazzi
No abstract text is available yet for this article.
June 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27613732/factors-associated-with-repeated-health-resource-utilization-in-patients-with-diverticulitis
#3
Steven N Mathews, Ryan Lamm, Jie Yang, Lijuan Kang, Dana Telem, Aurora D Pryor, Mark Talamini, Jill Genua
Conservative management trends in diverticulitis may lead to increased hospitalizations secondary to repeated attacks. The study aimed to characterize trends in management and risk-assess patients with diverticulitis that required multiple admissions to identify high utilizers. A total of 265,724 patients with diverticulitis were identified from 1995 to 2014 from the New York SPARCS database. Patients with ≥2 hospital admissions were stratified across demographics, comorbidities, insurance status, and surgical intervention...
September 9, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27604366/nineteen-year-trends-in-incidence-and-indications-for-laparoscopic-cholecystectomy-the-ny-state-experience
#4
Vamsi V Alli, Jie Yang, Jianjin Xu, Andrew T Bates, Aurora D Pryor, Mark A Talamini, Dana A Telem
BACKGROUND: Since the introduction of laparoscopic cholecystectomy (LC), there has been continued evolution in technique, instrumentation and postoperative management. With increased experience, LC has migrated to the outpatient setting. We asked whether increased availability and experience has impacted incidence of and indications for LC. METHODS: The New York (NY) State Planning and Research Cooperative System longitudinal administrative database was utilized to identify patients who underwent cholecystectomy between 1995 and 2013...
September 7, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27456012/20-year-trends-in-the-management-of-diverticulitis-across-new-york-state-an-analysis-of-265-724-patients
#5
Ryan Lamm, Steven N Mathews, Jie Yang, Lijuan Kang, Dana Telem, Aurora D Pryor, Mark Talamini, Jill Genua
INTRODUCTION: Management of acute diverticulitis (AD) has considerably changed over time. This study evaluates practice patterns for diverticulitis across demographic populations in New York State. METHODS: Two hundred sixty-five thousand seven hundred twenty-four patients with acute diverticulitis were analyzed from 1995 to 2014 from the New York-Statewide Planning and Research Cooperative System database. The likelihood of having surgery over time was compared across patient demographic subgroups using logistic regression models to calculate estimated odds ratio with their 95 % confidence intervals...
July 25, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27451226/determination-of-pesticides-in-coconut-cocos-nucifera-linn-water-and-pulp-using-modified-quechers-and-lc-ms-ms
#6
Jordana Alves Ferreira, Joana Maria Santos Ferreira, Viviane Talamini, Janice de Fátima Facco, Tiele Medianeira Rizzetti, Osmar Damian Prestes, Martha Bohrer Adaime, Renato Zanella, Carla Beatriz Grespan Bottoli
The use of pesticides is directly linked to improvements in productivity and to the preservation of coconut palms. However pesticide analysis is necessary to determine whether pesticide residues in the food products containing coconut are within the maximum residue limits (MRLs), ensuring the quality of these products. This work aimed to develop a method for multiresidue determination of ten pesticides in coconut water and pulp using QuEChERS and LC-MS/MS. The method was effective in terms of selectivity, linearity, matrix effect, accuracy and precision, providing LOD of 3μgkg(-1), LOQ of 10μgkg(-1) and recoveries between 70 and 120% with RSD lower than 20%...
December 15, 2016: Food Chemistry
https://www.readbyqxmd.com/read/27441900/protection-of-brain-injury-by-amniotic-mesenchymal-stromal-cell-secreted-metabolites
#7
Francesca Pischiutta, Laura Brunelli, Pietro Romele, Antonietta Silini, Eliana Sammali, Lara Paracchini, Sergio Marchini, Laura Talamini, Paolo Bigini, Giorgio B Boncoraglio, Roberta Pastorelli, Maria-Grazia De Simoni, Ornella Parolini, Elisa R Zanier
OBJECTIVES: To define the features of human amniotic mesenchymal stromal cell secretome and its protective properties in experimental models of acute brain injury. DESIGN: Prospective experimental study. SETTING: Laboratory research. SUBJECTS: C57Bl/6 mice. INTERVENTIONS: Mice subjected to sham or traumatic brain injury by controlled cortical impact received human amniotic mesenchymal stromal cells or phosphate-buffered saline infused intracerebroventricularly or intravenously 24 hours after injury...
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27369285/long-term-incidence-of-contralateral-primary-hernia-repair-following-unilateral-inguinal-hernia-repair-in-a-cohort-of-32-834-patients
#8
Richard Zheng, Maria S Altieri, Jie Yang, Hao Chen, Aurora D Pryor, Andrew Bates, Mark A Talamini, Dana A Telem
BACKGROUND: Asymptomatic contralateral inguinal hernias are often present during initial inguinal hernia repair. Data on long-term results and progression to symptomaticity are sparse. The purpose of this study was to assess long-term rates and risk factors for contralateral inguinal hernia repair following unilateral inguinal hernia repair. METHODS: Using New York Statewide Planning and Research Collaborative administrative data, 32,384 adults who underwent initial inguinal hernia repair during 2002-2003 in New York State and achieved 10-year follow-up were identified...
July 1, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27212031/activation-of-the-sdf1-cxcr4-pathway-retards-muscle-atrophy-during-cancer-cachexia
#9
G B Martinelli, D Olivari, A D Re Cecconi, L Talamini, L Ottoboni, S H Lecker, C Stretch, V E Baracos, O F Bathe, A Resovi, R Giavazzi, L Cervo, R Piccirillo
Cancer cachexia is a life-threatening syndrome that affects most patients with advanced cancers and causes severe body weight loss, with rapid depletion of skeletal muscle. No treatment is available. We analyzed microarray data sets to identify a subset of genes whose expression is specifically altered in cachectic muscles of Yoshida hepatoma-bearing rodents but not in those with diabetes, disuse, uremia or fasting. Ingenuity Pathways Analysis indicated that three genes belonging to the C-X-C motif chemokine receptor 4 (CXCR4) pathway were downregulated only in muscles atrophying because of cancer: stromal cell-derived factor 1 (SDF1), adenylate cyclase 7 (ADCY7), and p21 protein-activated kinase 1 (PAK1)...
December 1, 2016: Oncogene
https://www.readbyqxmd.com/read/27129561/effect-of-minimally-invasive-surgery-fellowship-on-residents-operative-experience
#10
Maria S Altieri, Catherine Frenkel, Richard Scriven, Deborah Thornton, Caitlin Halbert, Mark Talamini, Dana A Telem, Aurora D Pryor
INTRODUCTION: There is an increased need for surgical trainees to acquire advanced laparoscopic skills as laparoscopy becomes the standard of care in many areas of general surgery. Since the introduction of minimally invasive surgery (MIS) fellowships, there has been a continuing debate as to whether these fellowships adversely affect general surgery resident exposure to laparoscopic cases. The aim of our study was to examine whether the introduction of an MIS fellowship negatively impacts general surgery residents' experience at a single academic center...
April 29, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27064910/postoperative-quality-of-life-in-patients-with-ileal-neobladder-at-short-intermediate-and-long-term-follow-up
#11
Daniele D''Agostino, Marco Racioppi, Dario Pugliese, Mauro Ragonese, Luca Di Gianfrancesco, Alessio Filianoti, Giuseppe Palermo, Emanuele Belgrano, Salvatore Siracusano, Mauro Niero, Ciro Imbimbo, Massimo Iafrate, Walter Artibani, Maria Angela Cerruto, Renato Talamini, PierFrancesco Bassi
BACKGROUND: To evaluate the difference at different steps of follow-up of the postoperative quality of life (QoL) in patients who had undergone radical cystectomy and ileal orthotopic neobladder derivation. PATIENTS AND METHODS: A multicentric, cross-qualitative study was performed in 5 Italian centers of reference for the treatment of bladder cancer. One hundred seventy one patients who underwent radical cystectomy and creation of ileal orthotopic neobladder according to 'Vescica Ileale Padovana' between 2006 and 2011 have been analyzed...
2016: Urologia Internationalis
https://www.readbyqxmd.com/read/26987908/internalization-of-nanopolymeric-tracers-does-not-alter-characteristics-of-placental-cells
#12
Paolo Bigini, Elisa R Zanier, Silvia Saragozza, Simona Maciotta, Pietro Romele, Patrizia Bonassi Signoroni, Antonietta Silini, Francesca Pischiutta, Eliana Sammali, Claudia Balducci, Martina B Violatto, Laura Talamini, David Garry, Davide Moscatelli, Raffaele Ferrari, Mario Salmona, Maria Grazia De Simoni, Federico Maggi, Giuseppe Simoni, Francesca Romana Grati, Ornella Parolini
In the cell therapy scenario, efficient tracing of transplanted cells is essential for investigating cell migration and interactions with host tissues. This is fundamental to provide mechanistic insights which altogether allow for the understanding of the translational potential of placental cell therapy in the clinical setting. Mesenchymal stem/stromal cells (MSC) from human placenta are increasingly being investigated for their potential in treating patients with a variety of diseases. In this study, we investigated the feasibility of using poly (methyl methacrylate) nanoparticles (PMMA-NPs) to trace placental MSC, namely those from the amniotic membrane (hAMSC) and early chorionic villi (hCV-MSC)...
June 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/26905095/dietary-acrylamide-and-the-risk-of-endometrial-cancer-an-italian-case-control
#13
Claudio Pelucchi, Carlotta Galeone, Eva Negri, Cristina Bosetti, Diego Serraino, Maurizio Montella, Renato Talamini, Carlo La Vecchia
The role of dietary acrylamide on the risk of hormone-related, and specifically endometrial, cancers is debated. Epidemiological data are scanty. Thus, we examined the relation between acrylamide intake and endometrial cancer risk in a case-control study conducted between 1992 and 2006 in 3 Italian areas. Cases were 454 women with incident, histologically confirmed endometrial cancer. Controls were 908 age-matched women admitted to the same network of hospitals of cases for acute, non-neoplastic conditions...
2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/26858434/slow-dissolving-of-emotional-distress-contributes-to-hyperarousal
#14
Rick Wassing, Jeroen S Benjamins, Kim Dekker, Sarah Moens, Kai Spiegelhalder, Bernd Feige, Dieter Riemann, Sophie van der Sluis, Ysbrand D Van Der Werf, Lucia M Talamini, Matthew P Walker, Frans Schalkwijk, Eus J W Van Someren
The mechanisms underlying hyperarousal, the key symptom of insomnia, have remained elusive, hampering cause-targeted treatment. Recently, restless rapid-eye-movement (REM) sleep emerged as a robust signature of sleep in insomnia. Given the role of REM sleep in emotion regulation, we hypothesized that restless REM sleep could interfere with the overnight resolution of emotional distress, thus contributing to accumulation of arousal. Participants (n = 1,199) completed questionnaires on insomnia severity, hyperarousal, self-conscious emotional distress, and thought-like nocturnal mentation that was validated to be a specific proxy for restless REM sleep (selective fragmentation: R = 0...
March 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26823055/long-term-outcomes-of-patients-with-common-bile-duct-injury-following-laparoscopic-cholecystectomy
#15
Caitlin Halbert, Maria S Altieri, Jie Yang, Ziqi Meng, Hao Chen, Mark Talamini, Aurora Pryor, Purvi Parikh, Dana A Telem
INTRODUCTION: Common bile duct (CBD) injury is a serious and dreaded complication of cholecystectomy. A paucity of data assessing long-term outcomes exists. This study aimed to determine long-term mortality and liver transplantation rates following CBD injury requiring operative intervention. METHODS: Patients were identified via the New York State (NYS) Planning and Research Cooperative System longitudinal administrative database which captures patient-level data from every inpatient and outpatient hospital discharge in NYS...
October 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26819219/sages-assessment-on-the-da-vinci-surgical-system
#16
EDITORIAL
Mark A Talamini
No abstract text is available yet for this article.
March 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26791775/fate-of-pla-and-pcl-based-polymeric-nanocarriers-in-cellular-and-animal-models-of-triple-negative-breast-cancer
#17
Leopoldo Sitia, Raffaele Ferrari, Martina B Violatto, Laura Talamini, Luca Dragoni, Claudio Colombo, Laura Colombo, Monica Lupi, Paolo Ubezio, Maurizio D'Incalci, Massimo Morbidelli, Mario Salmona, Davide Moscatelli, Paolo Bigini
An integrated platform to assess the interaction between nanocarriers and biological matrices has been developed by our group using poly methyl-methacrylate nanoparticles. In this study, we exploited this platform to evaluate the behavior of two biodegradable formulations, poly-ε-caprolactone (PCL3) and poly lactic-acid (PLA8), respectively, in cellular and animal models of triple-negative breast cancer (TNBC). Both NPs shared the main physicochemical parameters (size, shape, ζ-potential) and exclusively differentiated on the material on which they are composed...
March 14, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/26727087/rates-and-risk-factors-for-unplanned-emergency-department-utilization-and-hospital-readmission-following-bariatric-surgery
#18
Dana A Telem, Jie Yang, Maria Altieri, Wendy Patterson, Brittany Peoples, Hao Chen, Mark Talamini, Aurora D Pryor
OBJECTIVE: To identify unplanned emergency resource utilization in the perioperative period following bariatric surgery. SUMMARY OF BACKGROUND DATA: Avoidable emergency department (ED) utilization and hospital readmissions pose a significant economic burden to our healthcare system. The extent of this problem is poorly studied in the bariatric literature. METHODS: Using New York statewide longitudinal administrative data, 38,776 patients, who underwent primary bariatric surgery from 2010 to 2013, were analyzed...
May 2016: Annals of Surgery
https://www.readbyqxmd.com/read/26659246/transanal-total-mesorectal-excision-tatme-for-rectal-cancer-a-training-pathway
#19
Elisabeth C McLemore, Christina R Harnsberger, Ryan C Broderick, Hyuma Leland, Patricia Sylla, Alisa M Coker, Hans F Fuchs, Garth R Jacobsen, Bryan Sandler, Vikram Attaluri, Anna T Tsay, Steven D Wexner, Mark A Talamini, Santiago Horgan
BACKGROUND: With increasing interest in natural orifice surgery, there has been a dramatic evolution of transanal and endoluminal surgical techniques. These techniques began with transanal endoluminal surgical removal of rectal masses and have progressed to transanal radical proctectomy for rectal cancer. The first transanal total mesorectal excision (taTME) was performed in 2009 by Sylla, Rattner, Delgado, and Lacy. The improved visibility and working space associated with the taTME technique is intriguing...
September 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26646264/risk-factors-for-early-onset-and-very-early-onset-pancreatic-adenocarcinoma-a-pancreatic-cancer-case-control-consortium-panc4-analysis
#20
MULTICENTER STUDY
Robert R McWilliams, Patrick Maisonneuve, William R Bamlet, Gloria M Petersen, Donghui Li, Harvey A Risch, Herbert Yu, Elizabeth T H Fontham, Brian Luckett, Cristina Bosetti, Eva Negri, Carlo La Vecchia, Renato Talamini, H Bas Bueno de Mesquita, Paige Bracci, Steven Gallinger, Rachel E Neale, Albert B Lowenfels
OBJECTIVES: While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years. METHODS: We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age- and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC...
February 2016: Pancreas
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