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https://www.readbyqxmd.com/read/29236903/ultrasound-analysis-of-tongue-contour-for-the-sound-j-in-adults-and-children
#1
Luciana da Silva Barberena, Simone Nicolini de Simoni, Rosalina Correa Sobrinho de Souza, Denis Altieri de Oliveira Moraes, Larissa Cristina Berti, Márcia Keske-Soares
PURPOSE: Analyze and compare the mean tongue contours and articulatory gestures in the production of the sound [j] in adults and children with typical and atypical speech development. The children with atypical development presented speech sound disorders. METHODS: The diagnosis was determined by speech assessments. The study sample was composed of 90 individuals divided into three groups: 30 adults with typical speech development aged 19-44 years (AT), 30 children with typical speech development (CT), and 30 children with speech sound disorders, named as atypical in this study, aged four years to eight years and eleven months (CA)...
December 11, 2017: CoDAS
https://www.readbyqxmd.com/read/29228830/twelve-tips-on-how-to-provide-self-regulated-learning-srl-enhanced-feedback-on-clinical-performance
#2
Heather Leggett, John Sandars, Trudie Roberts
The provision of self-regulated learning (SRL) enhanced feedback on performing clinical skills and making a clinical diagnosis recognizes the importance of feedback on the use of key SRL processes. In contrast to the broader concept of self-directed learning, SRL has a specific focus on the individual learner's approach to achieve a task, including their planning, self-monitoring, and future adaptations. The key SRL processes can be identified using structured microanalysis during the clinical task and feedback to the learner using the tips outlined in this article...
December 11, 2017: Medical Teacher
https://www.readbyqxmd.com/read/29228800/fifth-metatarsal-jones-fractures-in-the-athlete
#3
David A Porter
Fifth metatarsal fractures, otherwise known as "Jones" fractures, occur commonly in athletes and nonathletes alike. While recent occurrence in the popular elite athlete has increased public knowledge and interest in the fracture, this injury is common at all levels of sport. This review will focus on all three types of Jones fractures. The current standard for treatment is operative intervention with intramedullary screw fixation. Athletes typically report an acute episode of lateral foot pain, described as an ache...
December 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29224066/genome-wide-copy-number-alteration-detection-in-preimplantation-genetic-diagnosis
#4
Lieselot Deleye, Dieter De Coninck, Dieter Deforce, Filip Van Nieuwerburgh
Shallow whole genome sequencing has recently been introduced for genome-wide detection of chromosomal copy number alterations (CNAs) in preimplantation genetic diagnosis (PGD), using only 4-7 trophectoderm cells biopsied from day-5 embryos. This chapter describes the complete method, starting from whole genome amplification (WGA) on isolated blastomere(s), up to data analysis for CNA detection. The process is described generically and can also be used to perform CNA analysis on a limited number of cells (down to a single cell) in other applications...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29223145/antibody-biosensors-for-the-measurement-and-characterization-of-soluble-cd147-molecules
#5
Witida Laopajon, Nuchjira Takheaw, Saichit Khummuang, Tanyaluck Kampoun, Kantinan Cheunsirikulchai, Watchara Kasinrerk, Supansa Pata
BACKGROUND: Soluble CD147 (sCD147) is the shed form of membrane-bound CD147, which is involved in the regulation of cellular functions. The presence of sCD147 in body fluids is associated with several diseases. OBJECTIVE: In this study, we aimed to establish antibody (Ab) biosensors for the simultaneous differential detection of the general and truncated forms of sCD147. METHOD: By combining biolayer interferometry technology (BLItz) and different anti-CD147 monoclonal antibodies (mAbs) specific to different extracellular domains of the CD147 molecule, Ab-based biosensors were established to rapidly measure and characterize sCD147 isoforms...
December 10, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29202584/treatment-of-acute-portomesenteric-venous-thrombosis-with-thrombectomy-through-a-transjugular-intrahepatic-portosystemic-shunt-a-single-center-experience
#6
Kerstin Rosenqvist, Charlotte Ebeling Barbier, Fredrik Rorsman, Per Sangfelt, Rickard Nyman
Background Acute portomesenteric venous thrombosis (PMVT) is a potentially life-threatening condition and urgent treatment is required. Purpose To retrospectively evaluate the efficacy and safety of treating acute PMVT by the creation of a transjugular intrahepatic portosystemic shunt (TIPS) followed by thrombectomy. Material and Methods Six patients (all men, age range = 39-51 years) presenting with acute PMVT were treated with transjugular thrombectomy (TT) through a TIPS created in the same session. The intervention included iterated venography through the TIPS one to three times within the first week after diagnosis and repeated thrombectomy if needed (n = 5)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29202035/through-the-eustachian-tube-and-beyond-a-new-miniature-robotic-endoscope-to-see-into-the-middle-ear
#7
Loris Fichera, Neal P Dillon, Dongqing Zhang, Isuru S Godage, Michael A Siebold, Bryan I Hartley, Jack H Noble, Paul T Russell, Robert F Labadie, Robert J Webster
This paper presents a novel miniature robotic endoscope that is small enough to pass through the Eustachian tube and provide visualization of the middle ear (ME). The device features a miniature bending tip previously conceived of as a small-scale robotic wrist that has been adapted to carry and aim a small chip-tip camera and fiber optic light sources. The motivation for trans-Eustachian tube ME inspection is to provide a natural-orifice-based route to the ME that does not require cutting or lifting the eardrum, as is currently required...
2017: IEEE Robotics and Automation Letters
https://www.readbyqxmd.com/read/29200490/management-of-nail-bed-injuries-associated-with-fingertip-injuries
#8
Alexander George, Reena Alexander, C Manju
Background: Management of nail injuries can often be a challenging experience, especially in presence of complex fingertips' injuries that include soft tissue loss and distal phalanx injury. Most studies found in the literature focus on individual injuries and describe methods to tackle those injuries, notwithstanding the fact that the nail, nailbed, distal phalanx, soft tissue and skin of the finger tip form a complex and often more than one element of this complex is injured. This retrospective study therefore focuses on the management of nail bed injuries as a part of the complex finger tip injury and outlines the surgical principles and techniques that were used in their management...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29198478/the-evaluation-of-a-home-based-program-for-hands-in-patients-with-systemic-sclerosis
#9
Sibila Floriano Landim, Manoel Barros Bertolo, Marcos Felipe Marcatto de Abreu, Ana Paula Del Rio, Cecilia Carmen Mazon, João Francisco Marques-Neto, Janet L Poole, Eduardo de Paiva Magalhães
STUDY DESIGN: This study used a quasi-experimental design where patients were evaluated before and after participation in the self-management program. INTRODUCTION: Hands are commonly affected in systemic sclerosis (SSc). Strategies to maintain or improve hand function are indicated upon diagnosis and throughout the course of the disease. PURPOSE OF THE STUDY: The purpose of this study was to develop and evaluate a home-based program for hands in patients with SSc...
November 29, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29197841/haemorrhagic-conversion-of-infectious-myelitis-in-an-immunocompromised-patient
#10
Michael Stephen Pohlen, Jonathan Sunwei Lin, Kevin Yuqi Wang, Mohammad Ghasemi-Rad, Christie M Lincoln
A 28-year-old man recently diagnosed with HIV (CD4 19 cells/mm3, viral load 3.6 million copies/mL, not on highly active antiretroviral therapy on initial diagnosis at outside hospital), disseminated histoplasmosis, shingles and syphilis presented with paraplegia developing over 3 days. Spine MRI demonstrated a longitudinally extensive cord lesion extending from C3 to the tip of the conus. Brain MRI was consistent with meningoencephalitis. Cerebrospinal fluid findings were notable for positive varicella zoster virus (VZV) and cytomegalovirus (CMV) PCRs as well as a Venereal Disease Research Laboratory titre of 1:2...
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29188479/racial-disparity-in-breast-cancer-can-it-be-mattered-for-prognosis-and-therapy
#11
REVIEW
Vijayalaxmi Gupta, Inamul Haque, Jinia Chakraborty, Stephanie Graff, Snigdha Banerjee, Sushanta K Banerjee
Breast cancer (BC) has emerged as a deadly disease that affects the lives of millions of women worldwide. It is the second leading cause of cancer-related deaths in the United States. Advancements in BC screening, preventive measures and treatment have resulted in significant decline in BC related deaths. However, unacceptable levels of racial disparity have been consistently reported, especially in African-American (AA) women compared to European American (EA). AA women go through worse prognosis, shorter survival time and higher mortality rates, despite higher cancer incidence reported in EA...
November 29, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29183203/assessing-the-diagnostic-yield-of-controllable-biopsy-forceps-for-biliary-strictures
#12
Tadahisa Inoue, Rena Kitano, Yuji Kobayashi, Norimitsu Ishii, Kazumasa Sakamoto, Tomohiko Ohashi, Yukiomi Nakade, Yoshio Sumida, Kiyoaki Ito, Haruhisa Nakao, Masashi Yoneda
OBJECTIVE: Biliary forceps biopsies are essential for differentially diagnosing biliary strictures and evaluating the preoperative superficial intraductal spread of bile duct cancers; however, these biopsies are technically demanding and time consuming. Using controllable biopsy-forceps (C-BF), which enable the tip's angle to be adjusted by up to 90°, may facilitate the procedure and improve the diagnostic yield for biliary biopsies. This study aimed to examine the efficacy of C-BF associated with the diagnosis of biliary strictures...
November 28, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29180797/outcomes-of-variation-in-technique-and-variation-in-accuracy-of-measurement-in-penile-length-measurement
#13
Mohamad Habous, Gordon Muir, Tarek Soliman, Mohammed Farag, Ben Williamson, Saleh Binsaleh, Waleed Elhadek, Saad Mahmoud, Hussein Ibrahim, Osama Abdelwahab, Ziad Abdelrahman, Mohamed Abdelkader, Lawrence C Jenkins, John P Mulhall
Accurate data regarding the size of the erect penis is of great importance to several disciplines working with male patients, but little data exists on the best technique to measure penile length. While some previous small studies have suggested good correlation between stretched penile length, others have shown significant variability. Penile girth has been less well studied, and little data exist on the possible errors induced by differing observers and different techniques. Much of the published data report penile length measured from the penopubic skin junction-to-glans tip (STT) rather than pubic bone-to-tip (BTT)...
November 27, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29175575/brain-granuloma-rare-complication-of-a-retained-catheter-case-report
#14
Andrea Iaquinandi, Francesco Corrivetti, Pierpaolo Lunardi, Amedeo Ferlosio, Elena Giannini, Federica Novegno
BACKGROUND: Ventriculo-peritoneal (VP) shunt is the most frequent treatment for hydrocephalus. Its malfunctioning represents one of the most common problem in neurosurgical practice, often requiring shunt revision procedures. In some cases, the complete removal of a VP shunt may present difficulties, leading the surgeon to leave the ventricular catheter in situ. This decision is often taken in order to avoid possible adverse events, first of all, life-threatening hemorrhagic risks. However, a non-functioning catheter left in the ventricular system represents a prosthetic device which may lead to further complications...
November 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29169658/-symmetrical-peripheral-gangrene-4%C3%A2-cases
#15
F Smaoui, M Koubaa, K Rekik, Y Mejdoub, S Mezghani, I Maaloul, A Hammami, C Marrakchi, M Ben Jemaa
BACKGROUND: Symmetric peripheral gangrene (SPG) is a symmetrical distal ischemic lesion on at least 2 or more extremities in the absence of proximal arterial obstruction and vasculitis. It is a rare and severe clinical entity. The aim of this study was to describe clinical symptoms, etiological agents and the management of SPG through a series of 4 cases. PATIENTS AND METHODS: We included all cases of SPG hospitalized between 2000 and 2014. The inclusion criterion was the presence of distal ischemic damage at two or more sites in the absence of large vessel obstruction...
November 20, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29164762/recalibrated-meld-and-hepatic-encephalopathy-are-prognostic-factors-in-cirrhotic-patients-with-acute-variceal-bleeding
#16
Marika Rudler, Christophe Bureau, Nicolas Carbonell, Philippe Mathurin, Faouzi Saliba, Arianne Mallat, Julien Massard, Jean-Louis Golmard, Brigitte Bernard-Chabert, Nina Dib, Dominique Thabut
BACKGROUND: Early TIPS placement must be considered in patients with Child-Pugh B and active bleeding at endoscopy or in patients with Child-Pugh C 10-13 and variceal bleeding. However, active bleeding at endoscopy is a subjective criterion. Moreover, a previous study has shown that a MELD-based score accurately predicted 6-week mortality and helped to stratify patients. Using a prospective series of patients included in a multicentre study before the era of early TIPS, we aimed (1) to identify factors associated with 6-week mortality, focusing on the prognostic value of active bleeding; and (2) to assess whether a recalibrated MELD-based score accurately predicted 6-week mortality...
November 22, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29138706/radiological-diagnosis-of-a-rare-premature-aging-genetic-disorder-progeria-hutchinson-gilford-syndrome
#17
Haji Mohammed Nazir, Akshiitha Ramesh Baabhu, Yuvaraj Muralidharan, Seena Cheppala Rajan
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare disease with a combination of short stature, bone abnormalities, premature ageing, and skin changes. Though the physical appearance of these patients is characteristic, there is little emphasis on the characteristic radiological features. In this paper, we report a 16-year-old boy with clinical and radiological features of this rare genetic disorder. He had a characteristic facial appearance with a large head, large eyes, thin nose with beaked tip, small chin, protruding ears, prominent scalp veins, and absence of hair...
2017: Case Reports in Radiology
https://www.readbyqxmd.com/read/29131825/a-model-based-clustering-method-to-detect-infectious-disease-transmission-outbreaks-from-sequence-variation
#18
Rosemary M McCloskey, Art F Y Poon
Clustering infections by genetic similarity is a popular technique for identifying potential outbreaks of infectious disease, in part because sequences are now routinely collected for clinical management of many infections. A diverse number of nonparametric clustering methods have been developed for this purpose. These methods are generally intuitive, rapid to compute, and readily scale with large data sets. However, we have found that nonparametric clustering methods can be biased towards identifying clusters of diagnosis-where individuals are sampled sooner post-infection-rather than the clusters of rapid transmission that are meant to be potential foci for public health efforts...
November 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29105586/radial-styloidectomy-for-scaphoid-nonunion-advanced-collapse-relevance-of-nonunion-location
#19
Emil S Vutescu, Rishabh Jethanandani, Darryl B Sneag, Scott W Wolfe, Steve K Lee
Radial styloidectomy along with scaphoid nonunion reconstructive surgery is considered an acceptable surgical treatment for stage 1 scaphoid nonunion advanced collapse. The extent of radioscaphoid joint wear that defines scaphoid nonunion advanced collapse stage 1 is unclear. An appropriate radial styloidectomy is limited to 6 mm styloid removal to prevent carpal instability. The aim of this study was to determine whether nonunion fracture location can be a guiding factor in determining whether the scaphoid bone can be retained with scaphoid nonunion reconstructive surgery and radial styloidectomy...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29103006/a-rare-localised-nasal-cd30-primary-cutaneous-t-cell-lymphoma-following-liver-transplantation
#20
Quan M Nhu, Emma Z Du, Amirali Kiyani, Catherine T Frenette
Cutaneous T-cell post-transplant lymphoproliferative disorder (PTLD) is a rare clinical presentation that can potentially turn aggressive in solid-organ transplant recipients if not detected and intervened on early. We encountered a rare case of rapidly worsening primary cutaneous CD30-positive, Epstein-Barr virus-negative anaplastic large cell lymphoma (ALCL) of T-cell origin, manifesting as an isolated nasal tip lesion in a 71-year-old man 4 years after orthotopic liver transplantation. Excisional biopsy with partial rhinectomy showed subepithelial diffuse infiltration of medium-to-large lymphoid cells having round-to-irregular nuclei, partially condensed chromatin and prominent nucleoli...
November 4, 2017: BMJ Case Reports
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