Athina Andravizou, Sotiria Stavropoulou De Lorenzo, Evangelia Kesidou, Iliana Michailidou, Dimitrios Parissis, Marina-Kleopatra Boziki, Polyxeni Stamati, Christos Bakirtzis, Nikolaos Grigoriadis
Choroid plexus (CP) can be seen as a watchtower of the central nervous system (CNS) that actively regulates CNS homeostasis. A growing body of literature suggests that CP alterations are involved in the pathogenesis of multiple sclerosis (MS) but the underlying mechanisms remain elusive. CPs are enlarged and inflamed in relapsing-remitting (RRMS) but also in clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) stages, far beyond MS diagnosis. Increases in the choroid plexus/total intracranial volume (CP/TIV) ratio have been robustly associated with increased lesion load, higher translocator protein (TSPO) uptake in normal-appearing white matter (NAWM) and thalami, as well as with higher annual relapse rate and disability progression in highly active RRMS individuals, but not in progressive MS...
April 1, 2024: Healthcare (Basel, Switzerland)