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https://www.readbyqxmd.com/read/28335766/barriers-to-the-conduct-and-application-of-research-in-complementary-and-alternative-medicine-a-systematic-review
#1
Yasamin Veziari, Matthew J Leach, Saravana Kumar
BACKGROUND: The popularity of Complementary and alternative medicine (CAM) has grown considerably over the past few decades. This has been accompanied by increasing public pressure for CAM to be evidence-based. Notwithstanding, the conduct and application of research in CAM faces a number of obstacles. No systematic review has mapped these barriers to date. Therefore, this systematic literature review aimed to explore, identify and map the barriers to the conduct and application of research in CAM...
March 23, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28325795/the-pathophysiology-of-hyperglycemia-in-older-adults-clinical-considerations
#2
REVIEW
Pearl G Lee, Jeffrey B Halter
Nearly a quarter of older adults in the U.S. have type 2 diabetes, and this population is continuing to increase with the aging of the population. Older adults are at high risk for the development of type 2 diabetes due to the combined effects of genetic, lifestyle, and aging influences. The usual defects contributing to type 2 diabetes are further complicated by the natural physiological changes associated with aging as well as the comorbidities and functional impairments that are often present in older people...
April 2017: Diabetes Care
https://www.readbyqxmd.com/read/28323673/clinical-pearls-of-maternal-critical-care-part-2-sickle-cell-disease-in-pregnancy
#3
Vinod Patil, Gamunu Ratnayake, Galina Fastovets
PURPOSE OF REVIEW: The current review outlines the challenges in managing pregnant women with sickle-cell anemia, who are at risk of becoming critically ill during pregnancy. RECENT FINDINGS: Sickle obstetric patients pose unique challenges to the anesthetist and intensivist. We discuss the role of prophylactic transfusions for specific indications like acute anemia and twin pregnancies. The management and prevention of vaso-occlusive crises and chest crisis are also outlined...
March 18, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28314589/fgfr2-mutations-are-associated-with-poor-outcomes-in-endometrioid-endometrial-cancer-an-nrg-oncology-gynecologic-oncology-group-study
#4
Yvette W Jeske, Shamshad Ali, Sara A Byron, Feng Gao, Robert S Mannel, Rahel G Ghebre, Paul A DiSilvestro, Shashikant B Lele, Michael L Pearl, Amy P Schmidt, Heather A Lankes, Nilsa C Ramirez, Golnar Rasty, Matthew Powell, Paul J Goodfellow, Pamela M Pollock
PURPOSE: Activating FGFR2 mutations have been identified in ~10% of endometrioid endometrial cancers (ECs). We have previously reported that mutations in FGFR2 are associated with shorter disease free survival (DFS) in stage I/II EC patients. Here we sought to validate the prognostic importance of FGFR2 mutations in a large, multi-institutional patient cohort. METHODS: Tumors were collected as part of the GOG 210 clinical trial "Molecular Staging of Endometrial Cancer" where samples underwent rigorous pathological review and had more than three years of detailed clinical follow-up...
March 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28314558/a-patient-and-provider-research-agenda-on-diabetes-and-hypertension-management
#5
Emily B Zimmerman, Sarah K Cook, Amber D Haley, Steven H Woolf, Sarah K Price, Danielle Berman, Thomas DeLeire, Rebecca Etz, Jag Khalsa, Kirsten Knutson, Kathryn Kolasa, Alex Krist, Anton Kuzel, Pearl Lee, Theresa J Nartea, Gretchen Piatt, Hilary Seligman, Joni Strom Williams, Josh Brown, Jennifer Early, Jill Hellman, Julie Karr, Megan Kervin, Isra Malik, Albert Walker, Sheila Goode, Danita Gregory, Sharon Herman, Brenda Kenney, Chimere Miles, Audrey Smith, Travis White
INTRODUCTION: A demonstration project in Richmond, Virginia involved patients and other stakeholders in the creation of a research agenda on dietary and behavioral management of diabetes and hypertension. Given the impact of these diseases on morbidity and mortality, considerable research has been directed at the challenges patients face in chronic disease management. The continuing need to understand disparities and find evidence-based interventions to improve outcomes has been fruitful, but disparities and unmet needs persist...
March 14, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28289494/chronic-thromboembolic-pulmonary-hypertension-pearls-and-pitfalls-of-diagnosis
#6
Humna Abid Memon, C Huie Lin, Ashrith Guha
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by chronic obstruction of major pulmonary arteries by organized thromboembolic material. Untreated CTEPH can result in pulmonary hypertension and eventually right heart failure, yet it is the only form of pulmonary hypertension that is potentially curable with surgical or catheter-based intervention. While early diagnosis is key to increasing the likelihood of successful treatment, CTEPH remains largely underdiagnosed. This article reviews the role of echocardiogram, ventilation/perfusion scan, and other available modalities in the diagnosis of CTEPH...
October 2016: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28274766/design-strategies-and-applications-of-nacre-based-biomaterials
#7
REVIEW
Ethan Gerhard, Wei Wang, Caiyan Li, Jinshan Guo, Ibrahim Ozbolat, Kevin Rahn, April Armstrong, Jingfen Xia, Guoying Qian, Jian Yang
The field of tissue engineering and regenerative medicine relies heavily on materials capable of implantation without significant foreign body reactions and with the ability to promote tissue differentiation and regeneration. The field of bone tissue engineering in particular requires materials capable of providing enhanced mechanical properties and promoting osteogenic cell lineage commitment. While bone repair has long relied almost exclusively on inorganic, calcium phosphate ceramics such as hydroxyapatite and their composites or on non- degradable metals, the organically derived shell and pearl nacre generated by mollusks has emerged as a promising alternative...
March 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28240416/meeting-radiation-therapy-patients-informational-needs-through-educational-videos-augmented-by-3d-visualisation-software
#8
Katelyn Williams, Jenna Blencowe, Melissa Ind, David Willis
INTRODUCTION: Misconceptions and uncertainties about radiotherapy compound the anxiety patients experience at the commencement of treatment. This project investigated the utility of locally produced treatment process videos in meeting patients' informational needs. METHODS: In-house video production was conducted on a voluntary basis by staff and patients at a regional Australian radiotherapy centre. Videos included real footage and animated sections created with PEARL(TM) 3D visualisation software (Vertual Ltd, UK) to meet specific key content objectives...
March 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28235886/the-pearl-score-predicts-90-day-readmission-or-death-after-hospitalisation-for-acute-exacerbation-of-copd
#9
C Echevarria, J Steer, K Heslop-Marshall, S C Stenton, P M Hickey, R Hughes, M Wijesinghe, R N Harrison, N Steen, A J Simpson, G J Gibson, S C Bourke
BACKGROUND: One in three patients hospitalised due to acute exacerbation of COPD (AECOPD) is readmitted within 90 days. No tool has been developed specifically in this population to predict readmission or death. Clinicians are unable to identify patients at particular risk, yet resources to prevent readmission are allocated based on clinical judgement. METHODS: In participating hospitals, consecutive admissions of patients with AECOPD were identified by screening wards and reviewing coding records...
February 24, 2017: Thorax
https://www.readbyqxmd.com/read/28217015/the-pearl-of-fdg-pet-ct-in-preoperative-assessment-of-patients-with-potentially-operable-non-small-cell-lung-cancer-and-its-clinical-impact
#10
Boom Ting Kung, Ting Kun Au Yong, Cheuk Man Tong
The aim of this retrospective study is to evaluate the clinical impact and efficacy of fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) on management decisions for patients suffering from clinically operable non-small-cell lung cancer (NSCLC). A retrospective review of 186 potentially operable NSCLC patients who underwent whole-body PET/CT examination in 2012 was performed. The patients were further analyzed via the electronic patient record (ePR) system for relevant findings...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28205345/differential-diagnosis-of-well-differentiated-squamous-cell-carcinoma-from-non-neoplastic-oral-mucosal-lesions-new-cytopathologic-evaluation-method-dependent-on-keratinization-related-parameters-but-not-nuclear-atypism
#11
Hitoshi Hara, Tsuneo Misawa, Eri Ishii, Miki Nakagawa, Saki Koshiishi, Kenji Amemiya, Toshio Oyama, Kazuya Tominaga, Jun Cheng, Akio Tanaka, Takashi Saku
BACKGROUND: The cytology of oral squamous cell carcinoma (SCC) is challenging because oral SCC cells tend to be well differentiated and lack nuclear atypia, often resulting in a false negative diagnosis. The purpose of this study was to establish practical cytological parameters specific to oral SCCs. METHODS: We reviewed 123 cases of malignancy and 53 of non-neoplastic lesions of the oral mucosa, which had been diagnosed using both cytology and histopathology specimens...
February 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28197163/quinolizidine-alkaloid-biosynthesis-in-lupins-and-prospects-for-grain-quality-improvement
#12
REVIEW
Karen M Frick, Lars G Kamphuis, Kadambot H M Siddique, Karam B Singh, Rhonda C Foley
Quinolizidine alkaloids (QAs) are toxic secondary metabolites found within the genus Lupinus, some species of which are commercially important grain legume crops including Lupinus angustifolius (narrow-leafed lupin, NLL), L. luteus (yellow lupin), L. albus (white lupin), and L. mutabilis (pearl lupin), with NLL grain being the most largely produced of the four species in Australia and worldwide. While QAs offer the plants protection against insect pests, the accumulation of QAs in lupin grain complicates its use for food purposes as QA levels must remain below the industry threshold (0...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28194133/current-and-emerging-potential-of-magnetoencephalography-in-the-detection-and-localization-of-high-frequency-oscillations-in-epilepsy
#13
REVIEW
Eleonora Tamilia, Joseph R Madsen, Patricia Ellen Grant, Phillip L Pearl, Christos Papadelis
Up to one-third of patients with epilepsy are medically intractable and need resective surgery. To be successful, epilepsy surgery requires a comprehensive preoperative evaluation to define the epileptogenic zone (EZ), the brain area that should be resected to achieve seizure freedom. Due to lack of tools and methods that measure the EZ directly, this area is defined indirectly based on concordant data from a multitude of presurgical non-invasive tests and intracranial recordings. However, the results of these tests are often insufficiently concordant or inconclusive...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28193598/barriers-to-remote-health-interventions-for-type-2-diabetes-a-systematic-review-and-proposed-classification-scheme
#14
Michelle M Alvarado, Hye-Chung Kum, Karla Gonzalez Coronado, Margaret J Foster, Pearl Ortega, Mark A Lawley
BACKGROUND: Diabetes self-management involves adherence to healthy daily habits typically involving blood glucose monitoring, medication, exercise, and diet. To support self-management, some providers have begun testing remote interventions for monitoring and assisting patients between clinic visits. Although some studies have shown success, there are barriers to widespread adoption. OBJECTIVE: The objective of our study was to identify and classify barriers to adoption of remote health for management of type 2 diabetes...
February 13, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28191040/moisturisers-for-the-treatment-of-foot-xerosis-a-systematic-review
#15
REVIEW
Justin Parker, Rolf Scharfbillig, Sara Jones
BACKGROUND: Xerosis, literally dryness of the skin, of the foot is a common condition encountered clinically, which can lead to discomfort and predisposition to infection. Currently, there are no evidence-based recommendations on which moisturiser formulations best alleviate xerotic symptoms. The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis, by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28167953/biofortification-in-millets-a-sustainable-approach-for-nutritional-security
#16
REVIEW
A Vinoth, R Ravindhran
Nutritional insecurity is a major threat to the world's population that is highly dependent on cereals-based diet, deficient in micronutrients. Next to cereals, millets are the primary sources of energy in the semi-arid tropics and drought-prone regions of Asia and Africa. Millets are nutritionally superior as their grains contain high amount of proteins, essential amino acids, minerals, and vitamins. Biofortification of staple crops is proved to be an economically feasible approach to combat micronutrient malnutrition...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28156492/food-as-medicine-a-randomized-controlled-trial-rct-of-home-delivered-medically-tailored-meals-hdmtm-on-quality-of-life-qol-in-metastatic-lung-and-non-colorectal-gi-cancer-patients
#17
Raymond Mailhot Vega, Lisa Zullig, Alissa Wassung, Dorella Walters, Noah Berland, Kevin Lee Du, Jiyoung Ahn, Cynthia G Leichman, Deirdre Jill Cohen, Ping Gu, Abraham Chachoua, Lawrence P Leichman, Karen Pearl, Peter B Schiff
155 Background: Malnutrition incidence in cancer approaches 85%, disproportionately burdening those with lung, GI, and advanced stage cancers. Malnourished patients have impaired chemotherapy response, shorter survival, longer hospital stays, and decreased QoL. Home delivered meals are nutritional interventions that improve patient well-being, nutrition, and lower healthcare costs in the elderly but have not been studied as an intervention in cancer patients. HDMTM are nutritionist prescribed home delivered meals tailored to patient's symptoms, co-morbidities, and health needs...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28139826/neonatal-nonepileptic-myoclonus-is-a-prominent-clinical-feature-of-kcnq2-gain-of-function-variants-r201c-and-r201h
#18
Sarah B Mulkey, Bruria Ben-Zeev, Joost Nicolai, John L Carroll, Sabine Grønborg, Yong-Hui Jiang, Nishtha Joshi, Megan Kelly, David A Koolen, Mohamad A Mikati, Kristen Park, Phillip L Pearl, Ingrid E Scheffer, Rebecca C Spillmann, Maurizio Taglialatela, Silvia Vieker, Sarah Weckhuysen, Edward C Cooper, Maria Roberta Cilio
OBJECTIVE: To analyze whether KCNQ2 R201C and R201H variants, which show atypical gain-of-function electrophysiologic properties in vitro, have a distinct clinical presentation and outcome. METHODS: Ten children with heterozygous, de novo KCNQ2 R201C or R201H variants were identified worldwide, using an institutional review board (IRB)-approved KCNQ2 patient registry and database. We reviewed medical records and, where possible, interviewed parents and treating physicians using a structured, detailed phenotype inventory focusing on the neonatal presentation and subsequent course...
March 2017: Epilepsia
https://www.readbyqxmd.com/read/28137746/no-excess-of-cis-regulatory-variation-associated-with-intra-specific-selection-in-wild-pearl-millet-cenchrus-americanus
#19
Bénédicte Rhoné, Cédric Mariac, Marie Couderc, Cécile Berthouly-Salazar, Issaka Salia Ousseini, Yves Vigouroux
Several studies suggest that cis-regulatory mutations are the favorite target of evolutionary changes, one reason being that cis-regulatory mutations might have fewer deleterious pleiotropic effects than protein-coding mutations. A review of the process also suggests that this bias towards adaptive cis-regulatory variation might be less pronounced at the intra-specific level compared to the inter-specific level. In this study, we assessed the contribution of cis-regulatory variation to adaptation at the intra-specific level using populations of wild pearl millet (Cenchrus americanus ssp...
January 30, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28137544/contralateral-approach-for-minimally-invasive-treatment-of-upper-lumbar-intervertebral-disc-herniation-technical-note-and-case-series
#20
Ribhu T Jha, Hasan R Syed, Michael Catalino, Faheem A Sandhu
BACKGROUND: Upper lumbar disc herniations comprise only 1 to 2% of all lumbar disc herniations. Patients present with non-specific signs and symptoms in comparison to predictable radiculopathies as seen in lower lumbar disc herniations. The unique anatomical characteristics of the upper lumbar spine present several challenges for safe and effective surgical treatment of disc herniations. The authors review the anatomy of the upper lumbar spine, describe a novel approach to upper lumbar disc herniations, and present three cases with a focus on clinical outcome and technical pearls...
January 27, 2017: World Neurosurgery
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