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https://www.readbyqxmd.com/read/27922552/novel-use-of-all-trans-retinoic-acid-in-a-model-of-lipopolysaccharide-immunosuppression-to-decrease-the-generation-of-myeloid-derived-suppressor-cells-by-reducing-the-proliferation-of-cd34-precursor-cells
#1
Daiana Martire-Greco, Nahuel Rodriguez-Rodrigues, Luis A Castillo, María Belén Vecchione, Marcelo de Campos-Nebel, Marlina Córdoba Moreno, Roberto Meiss, Mónica Vermeulen, Veronica I Landoni, Gabriela C Fernandez
All-trans-Retinoic Acid (ATRA) is a derivative of vitamin A with anti-proliferative properties. Endotoxin shock and subsequent immunosuppression (IS) by lipopolysaccharide (LPS) stimulates myelopoiesis with expansion of myeloid-derived suppressor cells (MDSC). Since we have previously shown that ATRA reverses the IS state by decreasing functional MDSC, our aim was to investigate if ATRA was able to modulate MDSC generation by regulating myelopoiesis in murine hematopoietic organs. We found that ATRA administration in vivo and in vitro decreased the number of CD34+ precursor cells that were increased in IS mice...
November 25, 2016: Shock
https://www.readbyqxmd.com/read/27919949/1%C3%AE-dihydroxyvitamin-d3-and-retinoic-acid-increase-nuclear-vitamin-d-receptor-expression-in-monocytic-thp-1-cells
#2
Hikaru Uchida, Yuichiro Hasegawa, Hiromichi Takahashi, Makoto Makishima
BACKGROUND: 1α,25-Dihydroxyvitamin D3 [1,25(OH)2D3] and retinoic acid, such as all-trans retinoic acid (ATRA) and 9-cis retinoic acid (9cRA), are known to induce differentiation of myeloid leukemia cells. Combined treatment effectively enhances the differentiation effect, particularly in monocytic leukemia cells. The underlying mechanism of this combined effect remains unknown. MATERIALS AND METHODS: THP-1 monocytic leukemia cells were treated with 1,25(OH)2D3 in combination with 9cRA, ATRA or selective synthetic ligand for retinoic acid receptor (RAR) or retinoid X receptor (RXR), and the nuclear expression and function of vitamin D receptor (VDR) were examined...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919568/all-trans-retinoic-acid-suppresses-the-adhering-ability-of-arpe-19-cells-via-mitogen-activated-protein-kinase-and-focal-adhesion-kinase
#3
Yo-Chen Chang, Yuh-Shin Chang, Ming-Chu Hsieh, Horng-Jiun Wu, Meng-Hsien Wu, Chia-Wei Lin, Wen-Chuan Wu, Ying-Hsien Kao
This study investigated the signaling mechanism underlying the anti-adhesive effect of all-trans retinoic acid (ATRA) on retinal pigment epithelial ARPE-19 cells. Adhesion kinetics with or without ATRA treatment were profiled by adhesion assay. Surface coating with type IV collagen, fibronectin, laminin, but not type I collagen, significantly enhanced adhesion and spreading of ARPE-19 cells, while ATRA at subtoxic doses (ranging from 10(-7) to 10(-6) M) profoundly suppressed the extracellular matrix-enhanced adhesion ability...
November 16, 2016: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/27919176/recurrent-acute-myopericarditis-without-effusion-during-atra-induction-and-ato-salvage-of-apl-a-variant-form-of-the-differentiation-syndrome
#4
Theodoros P Vassilakopoulos, John V Asimakopoulos, Eleni Plata, Glafcos Kelepesis, Kyriaki Petevi, Catherine Koutsi, Loula Papageorgiou, Panayiotis Tsaftaridis, Maria K Angelopoulou, Konstantinos Konstantopoulos, John Meletis
No abstract text is available yet for this article.
December 6, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27895801/in-vitro-evaluation-of-a-combination-treatment-involving-anticancer-agents-and-an-aurora-kinase-b-inhibitor
#5
Senna Sakai, Hiroto Izumi, Yukiko Yoshiura, Yoshifumi Nakayama, Takahiro Yamaguchi, Yoshikazu Harada, Chiho Koi, Hiroyuki Kurata, Yasuo Morimoto
Aurora kinase B (AURKB) inhibitors are regarded as potential molecular-targeting drugs for cancer therapy. The present study evaluated the cytotoxic effect of a combination of AZD1152-hQPA, an AURKB inhibitor, and various anticancer agents on the HeLa human cervical cancer cell line, as well as its cisplatin-resistant equivalent HCP4 cell line. It was demonstrated that AZD1152-hQPA had an antagonistic effect on the cytotoxicity of cisplatin, etoposide and doxorubicin, but had a synergistic effect on that of all-trans-retinoic acid (ATRA), Am80 and TAC-101, when tested on HeLa cells...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27862498/all-trans-retinoic-acid-preconditioning-enhances-proliferation-angiogenesis-and-migration-of-mesenchymal-stem-cell-in-vitro-and-enhances-wound-repair-in-vivo
#6
M Pourjafar, M Saidijam, K Mansouri, H Ghasemibasir, F Karimi Dermani, R Najafi
OBJECTIVES: Stem cell therapy is considered to be a suitable alternative in treatment of a number of diseases. However, there are challenges in their clinical application in cell therapy, such as to reduce survival and loss of transplanted stem cells. It seems that chemical and pharmacological preconditioning enhances their therapeutic efficacy. In this study, we investigated effects of all-trans retinoic acid (ATRA) on survival, angiogenesis and migration of mesenchymal stem cells (MSCs) in vitro and in a wound-healing model...
November 10, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27856255/all-trans-retinoic-acid-depresses-the-content-and-activity-of-the-mitochondrial-atp-synthase-in-human-keratinocytes
#7
F Papa, R Lippolis, N Sardaro, A Gnoni, S Scacco
Proteomic analysis shows that treatment of keratinocytes cultures with all trans retinoic acid (ATRA), under condition in which it inhibits cell growth, results in marked decrease of the level of the F1-β subunit of the catalytic sector of the mitochondrial FoF1 ATP synthase complex. Enzymatic analysis shows in ATRA-treated keratinocytes a consistent depression of the ATPase activity, with decreased olygomycin sensitivity, indicating an overall alteration of the ATP synthase complex. These findings, together with the previously reported inhibition of respiratory complex I, show that depression of the activity of oxidative phosphorylation enzymes is involved in the cell growth inhibitory action of ATRA...
November 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27835920/-acute-myeloid-leukemia
#8
Jan Braess
Acute myeloid leukemia (AML) has been genetically characterized extensively and can now be subdivided into 9 to 11 pathogenetically different subtypes according to their profile of driver mutations. In clinical practice karyotyping and molecular analysis of NPM1, cEBPa and FLT3-ITD are required for treatment stratification and potentially genotype specific treatment. Some markers such as NPM1 not only offer prognostic information but can also serve as markers of minimal residual disease and thus have the potential to guide therapy in the future...
November 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27832522/combined-treatments-with-a-retinoid-receptor-agonist-and-epigenetic-modulators-in-human-neuroblastoma-cells
#9
Viviane Rösner Almeida, Igor Araujo Vieira, Marienela Buendia, André Tesainer Brunetto, Lauro J Gregianin, Algemir Lunardi Brunetto, Fábio Klamt, Caroline Brunetto de Farias, Ana Lucia Abujamra, Patrícia Luciana da Costa Lopez, Rafael Roesler
Neuroblastoma (NB) is the most common extracranial solid childhood tumor accounting for around 15% of pediatric cancer deaths and most probably originates from a failure in the development of embryonic neural crest cells. Retinoids can inhibit the proliferation and stimulate differentiation of NB cells. In addition, epigenetic events involving changes in chromatin structure and DNA methylation can mediate the effects of retinoids; hence, the scope of this study is to investigate the use of retinoids and epigenetic drugs in NB cell lines...
November 10, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27829536/anticancer-activity-of-all-trans-retinoic-acid-loaded-liposomes-on-human-thyroid-carcinoma-cells
#10
Maria Chiara Cristiano, Donato Cosco, Christian Celia, Andra Tudose, Rosario Mare, Donatella Paolino, Massimo Fresta
All-trans retinoic acid (ATRA) is an anti-tumor compound, exerting different anti-cancer effects on different types of cancer cells. Unfortunately, retinoids are also characterized by certain side effects following systemic administration, such as the burning of skin and general malaise. The highly variable degree of bioavailability of ATRA plus its tendency to induce its own destruction through metabolic degradation following oral treatment necessitate the development of alternative formulations. The aim of this work is to evaluate the physico-chemical properties of unilamellar, ATRA-containing liposomes and to investigate the cytotoxic activity of this potential nanomedicine on human thyroid carcinoma cells...
November 4, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27809850/the-association-and-significance-of-h3k27me3-and-a-folate-metabolic-gene-acat2-in-neural-tube-defects
#11
Sifan Zhai, Mingzuo Zhao, Changcheng Zhou, Fenggang Lu, Huankai Zhang, Li Na, Shanshan Feng, Xiaoxin Qiang, Yong Du
AIM: To study the association between the expression of H3K27me3 and ACat2 (a folate metabolic protein), in order to elucidate the protective mechanism of folic acid (FA) in neural tube defects (NTDs). METHODS: Eighteen female SD rats were randomly divided into normal, NTD and FA group. NTD group was induced by all-trans retinoic acid (ATRA) at E10d. FA group was fed with FA supplementation since 2 weeks before pregnancy, followed by ATRA induction. At E15d, FA level in the embryonic neural tube was determined by ELISA...
November 3, 2016: Nutrition Journal
https://www.readbyqxmd.com/read/27807597/analysis-of-the-interplay-between-all-trans-retinoic-acid-and-histone-deacetylase-inhibitors-in-leukemic-cells
#12
Katrin Noack, Nisintha Mahendrarajah, Dorle Hennig, Luisa Schmidt, Florian Grebien, Dagmar Hildebrand, Markus Christmann, Bernd Kaina, Andreas Sellmer, Siavosh Mahboobi, Katharina Kubatzky, Thorsten Heinzel, Oliver H Krämer
The treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) induces granulocytic differentiation. This process renders APL cells resistant to cytotoxic chemotherapies. Epigenetic regulators of the histone deacetylases (HDACs) family, which comprise four classes (I-IV), critically control the development and progression of APL. We set out to clarify the parameters that determine the interaction between ATRA and histone deacetylase inhibitors (HDACi). Our assays included drugs against class I HDACs (MS-275, VPA, and FK228), pan-HDACi (LBH589, SAHA), and the novel HDAC6-selective compound Marbostat-100...
November 2, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27806872/all-trans-retinoic-acid-atra-prevents-lipopolysaccharide-induced-neuroinflammation-amyloidogenesis-and-memory-impairment-in-aged-rats
#13
Nassima Behairi, Mourad Belkhelfa, Hayet Rafa, Moussa Labsi, Nahla Deghbar, Nora Bouzid, Hamida Mesbah-Amroun, Chafia Touil-Boukoffa
We aimed to investigate preventive effects of All-trans retinoic acid (ATRA) on a lipopolysaccharide (LPS)-induced aged neuroinflammation model. We analyzed behavior, systemic nitric oxide (NO) production, cerebral NO synthase (NOS2) and β-amyloid (Aβ) 1-42 expression and tissue integrity in the neuroinflammation model pretreated with ATRA (150μg/ml/rat/day) for 30days. Our results showed that LPS treatment (500μg/kg/day) for 7days disturbed memory, enhanced systemic NO production, NOS2 and Aβ 1-42 cerebral expression and generated an Alzheimer's disease (AD)-like neuronal degeneration...
November 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27779644/all-trans-retinoic-acid-shifts-rosiglitazone-induced-adipogenic-differentiation-to-osteogenic-differentiation-in-mouse-embryonic-fibroblasts
#14
Ying Shao, Qian-Zhao Chen, Yu-Hua Zeng, Yang Li, Wen-Yan Ren, Lin-Yun Zhou, Rong-Xin Liu, Ke Wu, Jun-Qing Yang, Zhong-Liang Deng, Yu Yu, Wen-Juan Sun, Bai-Cheng He
Rosiglitazone (RSG) is a potent drug used in the treatment of insulin resistance; however, it is associated with marked skeletal toxicity. RSG-induced osteoporosis may contribute to the promotion of adipogenic differentiation at the expense of osteogenic differentiation in bone marrow stromal cells. The aim of this study was to investigate whether RSG-induced bone toxicity can be reversed by combined treatment with all-trans retinoic acid (ATRA). We examined different osteogenic markers in mouse embryonic fibroblasts (MEFs) following treatment with RSG, ATRA, or RSG and ATRA in combination...
October 19, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27769742/all-trans-retinoic-acid-promotes-wound-healing-of-primary-amniocytes-through-the-induction-of-loxl4-a-member-of-the-lysyl-oxidase-family
#15
Marion Rouzaire, Aurélie Comptour, Corinne Belville, Damien Bouvier, Gaël Clairefond, Flora Ponelle, Vincent Sapin, Denis Gallot, Loïc Blanchon
Thirty percent of preterm births directly result from preterm premature rupture of fetal membranes (PPROM). Clinical management currently proposes using a collagen plug to mechanically stop loss of amniotic fluid. Vitamin A and its active metabolite (retinoic acid) have well-known pro-healing properties and could thus make good candidates as a proposable adjuvant to this mechanical approach. Here we investigate the molecular mechanisms involved in the pro-healing properties of all-trans retinoic acid (atRA) in fetal membranes via an approach using an in vitro primary amniocyte wound model and transcriptomics...
October 18, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27762589/hpma-copolymer-based-polymer-conjugates-for-the-delivery-and-controlled-release-of-retinoids
#16
O Lidický, M Šírová, T Etrych
In this paper, we describe the synthesis, physicochemical characterization, drug release kinetics and preliminary biological evaluation of several N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymer-retinoid conjugates designed for solid tumor immunotherapy. The conjugates are supposed to inhibit the immunosuppressive activity of myeloid-derived suppressor cells (MDSC) accumulated in the solid tumor microenvironment. All-trans retinoic acid (ATRA) was derivatized to hydrazide (AtrHy) and then attached to the polymer backbone via a spacer that is stable at the normal pH of blood (7...
October 20, 2016: Physiological Research
https://www.readbyqxmd.com/read/27761836/analyzing-the-impact-of-pan-and-class-specific-hdaci-on-differentiation-associated-factors
#17
Katrin Noack, Oliver H Krämer
The differentiation of hematopoietic stem cells into mature blood cells is a highly ordered process and dysregulation of this process can lead to leukemogenesis. Agents that are used to cure acute promyelocytic leukemia (APL) can induce differentiation and/or apoptosis. Here, we describe how effects of all-trans retinoic acid (ATRA) and histone deacetylase inhibitors (HDACi) on APL cell differentiation can be evaluated by immunoblotting and by flow cytometry. We show how the levels of differentiation-associated transcription factors of the CCAAT enhancer binding protein (C/EBP) family can be determined by Western blot and we explain how the cell surface expression of the leukocyte surface antigen CD11b can be measured by flow cytometry...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27754752/rhoa-controls-retinoid-signaling-by-rock-dependent-regulation-of-retinol-metabolism
#18
Alberto García-Mariscal, Karine Peyrollier, Astrid Basse, Esben Pedersen, Ralph Rühl, Jolanda van Hengel, Cord Brakebusch
The ubiquitously expressed small GTPase RhoA is essential for embryonic development and mutated in different cancers. Functionally, it is well described as a regulator of the actin cytoskeleton, but its role in gene regulation is less understood. Using primary mouse keratinocytes with a deletion of the RhoA gene, we have now been exploring how the loss of RhoA affects gene expression. Performing transcription factor reporter assays, we found a significantly decreased activity of a RAR luciferase reporter in RhoA-null keratinocytes...
October 18, 2016: Small GTPases
https://www.readbyqxmd.com/read/27741318/selection-of-the-inducer-for-the-differentiation-of-chicken-embryonic-stem-cells-into-male-germ-cells-in-vitro
#19
Yani Zhang, Yingjie Wang, Qisheng Zuo, Xiaoyan Wang, Dong Li, Beibei Tang, Bichun Li
Several inducers have been used to differentiate embryonic stem cells (ESCs) into male germ cells but the induction process has been inefficient. To solve the problem of low efficiency of inducer for ESCs differentiation into male germ cells, all-trans retinoic acid (ATRA), Am80(the retinoic acid receptor agonist), and estradiol (E2) was used to induce ESCs to differentiate into male germ cells in vitro. ESCs were cultured in media containing ATRA, Am80, or E2 respectively which can differentiate ESCs into a germ cell lineage...
2016: PloS One
https://www.readbyqxmd.com/read/27740626/the-lncrna-hotairm1-regulates-the-degradation-of-pml-rara-oncoprotein-and-myeloid-cell-differentiation-by-enhancing-the-autophagy-pathway
#20
Zhen-Hua Chen, Wen-Tao Wang, Wei Huang, Ke Fang, Yu-Meng Sun, Shu-Rong Liu, Xue-Qun Luo, Yue-Qin Chen
Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are of great importance in different cell contexts. However, only a very small number of lncRNAs have been experimentally validated and functionally annotated during human hematopoiesis. Here, we report an lncRNA, HOTAIRM1, which is associated with myeloid differentiation and has pivotal roles in the degradation of oncoprotein PML-RARA and in myeloid cell differentiation by regulating autophagy pathways. We first revealed that HOTAIRM1 has different variants that are expressed at different levels in cells and that the expression pattern of HOTAIRM1 is closely related to that of the PML-RARA oncoprotein in acute promyelocytic leukemia (APL) patients...
October 14, 2016: Cell Death and Differentiation
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