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https://www.readbyqxmd.com/read/29777906/reduced-rar-%C3%AE-gene-expression-in-benzo-a-pyrene-induced-lung-cancer-mice-is-upregulated-by-dotap-lipo-atra-treatment
#1
S Viswanathan, V M Berlin Grace
Molecular targeted therapy for specific genes is an emerging research. Retinoic Acid Receptor (RAR-β) is a key tumor suppressor which is found to be lost drastically during much cancer progression. We hence, analyzed the expression level of RAR-β gene during B(a)P induced lung cancer development in mice and studied the lung cancer targeted action of All Trans Retinoic Acid (ATRA) in DOTAP liposomal formulation. The effect of its treatment on lung cancer was determined by histopathological analysis. RAR-β gene expression was assessed by RT-PCR and qPCR...
May 16, 2018: Gene
https://www.readbyqxmd.com/read/29772445/the-protective-role-of-all-transretinoic-acid-atra-against-colorectal-cancer-development-is-achieved-via-increasing-mir-3666-expression-and-decreasing-e2f7-expression
#2
Weihong Liu, Yanqiu Song, Chenggui Zhang, Pengfei Gao, Bisheng Huang, Jianfang Yang
OBJECTIVE: Colorectal cancer (CRC) is one of the most common malignancies with high morbidity and mortality rates worldwide. This study aimed to investigate whether miR-3666 was involved in inhibitory effects of all-transretinoic acid (ATRA) on the development of colorectal cancer (CRC). MATERIAL AND METHODS: Surgical specimens of CRC tissues and adjacent non-tumor mucosa were collected for determining miR-3666 expression. Human CRC HCT116 cells were treated with different doses of ATRA (10, 20, 40, and 60 μM, respectively) and/or transfected with miR-3666 mimic, miR-3666 inhibitor, E2F7 siRNAs or their controls, respectively...
May 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29767236/fenretinide-inhibits-the-proliferation-and-migration-of-human-liver-cancer-hepg2-cells-by-downregulating-the-activation-of-myosin-light-chain-kinase-through-the-p38%C3%A2-mapk-signaling-pathway
#3
Ling Zhang, Daobin Huang, Decui Shao, Hui Liu, Qing Zhou, Shuyu Gui, Wei Wei, Yuan Wang
N-(4-hydroxyphenyl)retinamide (4-HPR or fenretinide), which is a synthetic analog of all‑trans retinoic acid (ATRA), effectively inhibits the growth of several types of tumor cells; however, its molecular mechanism remains unclear. We found that 4‑HPR altered the morphology of human liver cancer HepG2 cells and also inhibited their proliferation and suppressed the colony formation in a dose‑ and time‑dependent manner. A wound healing assay revealed that 4‑HPR significantly hindered HepG2 cell migration, and that this was accompanied by the phosphorylation of p38‑MAPK (mitogen‑activated protein kinase)...
May 16, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29757260/involvement-of-mafb-and-maff-in-retinoid-mediated-suppression-of-hepatocellular-carcinoma-invasion
#4
Hiroyuki Tsuchiya, Seiya Oura
Retinoids exert antitumor effects through the retinoic acid receptor α (RARα). In the present study, we sought to identify the factors involved in the RARα-mediated transcriptional regulation of the tumor suppressor gene and the tissue factor pathway inhibitor 2 (TFPI2) in hepatocellular carcinoma (HCC). All- trans -retinoic acid (ATRA) was used in the in vitro experiments. Cell invasiveness was measured using trans-well invasion assay. ATRA significantly increased TFPI2 expression through RARα in a human HCC cell line known as HuH7...
May 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29748133/retinoic-acid-inhibits-neuronal-voltage-gated-calcium-channels
#5
Eric de Hoog, Mark K Lukewich, Gaynor E Spencer
Retinoic acid is the active metabolite of vitamin A and regulates several important cellular processes by activating retinoic acid receptors (RAR) and retinoid X receptors (RXR). These receptors generally act as transcription factors, though non-genomic actions of both retinoic acid and the receptors have also been reported. One such nongenomic effect includes the modulation of Ca2+ levels during homeostatic synaptic plasticity in the hippocampus. Retinoic acid can thus affect Ca2+ signaling and can potentially control both synaptic plasticity and neuronal firing...
February 13, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29743969/low-autophagy-atg-gene-expression-is-associated-with-an-immature-aml-blast-cell-phenotype-and-can-be-restored-during-aml-differentiation-therapy
#6
Jing Jin, Adrian Britschgi, Anna M Schläfli, Magali Humbert, Deborah Shan-Krauer, Jasmin Batliner, Elena A Federzoni, Marion Ernst, Bruce E Torbett, Shida Yousefi, Hans-Uwe Simon, Mario P Tschan
Autophagy is an intracellular degradation system that ensures a dynamic recycling of a variety of building blocks required for self-renewal, homeostasis, and cell survival under stress. We used primary acute myeloid leukemia (AML) samples and human AML cell lines to investigate the regulatory mechanisms of autophagy and its role in AML differentiation. We found a significantly lower expression of key autophagy- (ATG-) related genes in primary AML as compared to healthy granulocytes, an increased autophagic activity during all- trans retinoic acid- (ATRA-) induced neutrophil differentiation, and an impaired AML differentiation upon inhibition of ATG3, ATG4D, and ATG5...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29743722/management-of-patients-with-acute-promyelocytic-leukemia
#7
REVIEW
Sabine Kayser, Richard F Schlenk, Uwe Platzbecker
With the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) acute promyelocytic leukemia (APL) has become from a detrimental to one of the most curable malignant diseases in humans. In particular, the chemotherapy-free regimen with ATO/ATRA has been proven to be highly effective in de novo APL and has become standard first-line therapy in younger adult, non-high-risk patients. Nevertheless, early death is still a major issue in APL, particularly in older patients, emphasizing the need of rapid diagnostics and supportive care together with immediate access to ATRA-based therapy...
April 24, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29743401/-hypoplastic-acute-promyelocytic-leukemia-with-continuous-hypocellular-bone-marrow-after-remission
#8
Toshiki Nakamura, Junya Makiyama, Ayumi Matsuura, Hirokazu Kurohama, Hideaki Kitanosono, Masahiro Ito, Shinichiro Yoshida, Yasushi Miyazaki
An 87-year old female presented with unsteady gait and occasional subcutaneous hematomas. Blood examination findings revealed pancytopenia and mild coagulopathy. Both the histopathological evaluation of bone marrow smears and bone marrow biopsy revealed a hypocellular bone marrow. However, APL cells were observed and PML-RARA fusion gene was detected. On the basis of these findings, the patient was diagnosed with hypoplastic acute promyelocytic leukemia. She received ATRA treatment and achieved complete remission (CR) 29 days from the commencement of therapy...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29730892/activation-of-p70s6-kinase-1-in-mesenchymal-stem-cells-is-essential-to-lung-tissue-repair
#9
Katsuyuki Takeda, Fangkun Ning, Joanne Domenico, Masakazu Okamoto, Shigeru Ashino, Sang-Ha Kim, Yi Yeong Jeong, Yoshiki Shiraishi, Naohiro Terada, Everett Rand Sutherland, Erwin W Gelfand
All-trans retinoic acid (ATRA) or mesenchymal stem cells (MSCs) have been shown to promote lung tissue regeneration in animal models of emphysema. However, the reparative effects of the combination of the two and the role of p70S6 kinase-1 (p70S6k1) activation in the repair process have not been defined. Twenty-one days after intratracheal instillation of porcine pancreatic elastase (PPE), MSC and/or 10 days of ATRA treatment was initiated. Thirty-two days later, static lung compliance (Cst), mean linear intercepts (MLIs), and alveolar surface area (S) were measured...
May 5, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29722138/behavioural-thermoregulation-is-highly-repeatable-and-unaffected-by-digestive-status-in-agama-atra
#10
Jenna van Berkel, Susana Clusella-Trullas
The precision and the extent of behavioral thermoregulation are likely to provide fitness benefits to ectotherms. Yet the factors driving variation in selected or preferred body temperature (Tset ) and its usefulness as a proxy for optimal physiological temperature (Topt ) are still debated. Although Tset is often conserved among closely related species, substantial variation at the individual, population, and species level has also been reported but repeatability (sensu the intra-class correlation coefficient, ICC) of Tset is generally low...
May 3, 2018: Integrative Zoology
https://www.readbyqxmd.com/read/29715087/tumor-cell-selective-synergism-of-trail-and-atra-induced-cytotoxicity-in-breast-cancer-cells
#11
Annekathrin Reinhardt, Hongyu Liu, Yunxia Ma, Yongan Zhou, Chuanbing Zang, Jan-Piet Habbel, Kurt Possinger, Jan Eucker
BACKGROUND/AIM: One of the major problems in breast cancer treatment is pharmacoresistance. Therefore, exploration of treatment alternatives is of clinical relevance. The present work focused on tumor cell-inhibiting effects of a combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and all trans retinoic acid (ATRA) in breast cancer cells. MATERIALS AND METHODS: Breast cancer cell lines (BT-20, BT-474, MDA-MB-231, MDA-MB-436, MDA-MB-453, MCF-7, SKBR3, T47D, ZR-75-1) and the mammary epithelial cell line MCF-10A were treated with TRAIL and ATRA alone and in combination...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29703489/mechanisms-and-management-of-coagulopathy-in-acute-promyelocytic-leukemia
#12
Sachin David, Vikram Mathews
Acute promyelocytic leukemia (APL) is a subtype of leukemia which is associated with unique and distinctive coagulopathy. In the absence of treatment it is rapidly fatal and even after initiation of therapy the major cause of early mortality is related to hemorrhagic complications. The coagulopathy can be exacerbated with the start of treatment. In the absence of early hemorrhage related deaths the probability of cure exceeds 90% in low and intermediate risk patients and 80% even in high risk patients, highlighting the importance of understanding the pathophysiology of this complication and instituting prompt and appropriate management strategies...
April 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29699387/the-bromodomain-inhibitor-jq1-enhances-the-responses-to-all-trans-retinoic-acid-in-hl-60-and-mv4-11-leukemia-cells
#13
Changhee Kang, C-Yoon Kim, Hyuk Soon Kim, Se-Pill Park, Hyung-Min Chung
All- trans retinoic acid (ATRA) is a highly effective treatment for acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML). However, ATRA-based treatment is not effective in other subtypes of AML. In non-APL AML, ATRA signaling pathway is impaired or downmodulated, and consequently fails to respond to pharmacological doses of ATRA. Therefore, complementary treatment strategies are needed to improve ATRA responsiveness in non-APL AML. In this study, we investigated the combined effect of ATRA and bromodomain inhibitor JQ1, proven to have potent anti-cancer activity mainly through inhibition of c-Myc...
April 30, 2018: International Journal of Stem Cells
https://www.readbyqxmd.com/read/29689339/mitochondrial-dysfunction-is-implicated-in-retinoic-acid-induced-spina-bifida-aperta-in-rat-fetuses
#14
Jia Xue, Hui Gu, Dan Liu, Wei Ma, Xiaowei Wei, Lianshuai Zhao, Yusi Liu, Chaonan Zhang, Zhengwei Yuan
Neural tube defects (NTDs) are the most common and severe congenital malformations, which result from failure of the neural tube to close during embryonic development. The etiology of NTDs is complex, caused by interactions between genetic defects and environmental factors, but the exact mechanisms of this disease are still not fully understood. We herein employ a Seahorse Bioscience microplate-based extracellular flux (XF) analyzer to determine mitochondrial function and quantify respiratory coupling to various bioenergetic functions using specific pharmacological inhibitors of bioenergetic pathways...
April 21, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29688535/all-trans-retinoic-acid-increases-the-expression-of-oxidative-myosin-heavy-chain-through-the-ppar%C3%AE-pathway-in-bovine-muscle-cells-derived-from-satellite-cells
#15
Jongkyoo Kim, Kimberly B Wellmann, Zachary K Smith, Bradley J Johnson
All-trans retinoic acid (ATRA) has been associated with various physiological phenomenon in mammalian adipose tissue and skeletal muscle. We hypothesized that ATRA may affect skeletal muscle fiber type in bovine satellite cell culture through various transcriptional processes. Bovine primary satellite cell (BSC) culture experiments were conducted to determine dose effects of ATRA on expression of genes and protein levels related to skeletal muscle fiber type and metabolism. The semimembranosus from crossbred steers (n = 2 steers), aged approximately 24 months, were used to isolate BSC for 3 separate assays...
April 24, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29687464/protective-effects-of-sea-cucumber-holothuria-atra-extract-on-testicular-dysfunction-induced-by-immune-suppressant-drugs-in-wistar-rats
#16
D Y Saad, M M Soliman, A A Mohamed, G B Youssef
The current study was aimed to evaluate the protective effect of Holothurian atra (HA) extract; naturally occurring marine resource, against methotrexate (MTX) induced testicular dysfunction. Mature rats received either MTX (20 mg/kg, intraperitoneally) or saline on the 7th day of experiment al design. Seven days prior and after MTX-injection, rats received HA at dose of 300 mg/kg intragastrically (HA + MTX group; HA group alone). Serum was extracted and testicular tissues were examined for the changes in serum biochemistry (liver & kidney biomarkers, testicular hormones and antioxidants), molecular and histopthological alterations using RT-PCR and immunohistochemistry...
April 23, 2018: Andrologia
https://www.readbyqxmd.com/read/29677631/enhancement-of-monoclonal-antibody-production-after-single-and-combination-treatment-of-the-hybridoma-cells-with-all-trans-retinoic-acid-and-docosahexaenoic-acid-an-in-vitro-and-in-vivo-study
#17
Mohsen Rokni, Ali Reza Razavi, Fazel Shokri, Kazem Ahmadi Kia, Farid Solaymani-Mohammadi, Reza Chahardoli, Ali Akbar Saboor-Yaraghi
Murine hybridoma cells can produce monoclonal antibody (MAb) and the production of these antibodies in culture and peritoneum can be affected by different factors, including stimulants, inhibitors and supplements. Among these factors, the impact of micronutrients on the production of MAbs by mouse hybridoma cells has not fully been explored. In this study the murine hybridoma cells, M3C5, were cultured and treated with different concentrations of ATRA and DHA, alone, in combinations, and at different time of exposure...
April 17, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29674477/blockade-of-myeloid-derived-suppressor-cell-expansion-with-all-trans-retinoic-acid-increases-the-efficacy-of-anti-angiogenic-therapy
#18
Raimund Bauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ines Miranda Santos, Federico Taverna, Meike Kuhlencord, Victoria Gensch, Sarina Päsler, Stefan Vinckier, Johanna M Brandner, Klaus Pantel, Carsten Bokemeyer, Thomas Vogl, Johannes Roth, Peter Carmeliet, Sonja Loges
Intrinsic and adaptive resistance hamper the success of anti-angiogenic therapies (AAT), especially in breast cancer where this treatment modality has proven largely ineffective. Therefore, novel strategies to improve the efficacy of AAT are warranted. Solid tumors such as breast cancer are characterized by a high infiltration of myeloid-derived suppressor cells (MDSC) which are key drivers of resistance to AAT. Therefore, we hypothesized that all-trans retinoic acid (ATRA), which induces differentiation of MDSC into mature cells, could improve the therapeutic effect of AAT...
April 19, 2018: Cancer Research
https://www.readbyqxmd.com/read/29668727/correction-novel-naja-atra-cardiotoxin-1-ctx-1-derived-antimicrobial-peptides-with-broad-spectrum-activity
#19
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0190778.].
2018: PloS One
https://www.readbyqxmd.com/read/29650946/a-rare-case-of-relapsed-pediatric-acute-promyelocytic-leukemia-with-skin-involvement-by-myeloid-sarcoma
#20
Nathalia Silva Araújo, Claudio José Dos Santos Júnior, Vitória Mikaelly da Silva Gomes, Luiz Arthur Calheiros Leite, Luana Novaes Bomfim, Amanda Katielly Firmino da Silva Gusmão, Maria Jordana Rocha Gomes Alves, Cyndi Myrelle da Silva Barros Romão, Arthur Moacir Costa Sampaio Batinga, Maria Rosa da Silva, Célio Fernando de Sousa Rodrigues
BACKGROUND Acute promyelocytic leukemia (APL) is a very rare leukemia in children. Extramedullary involvement by APL has been reported in between 3-5% of cases, mainly associated with cases of relapse. A rare case of relapse of APL in a 9-year-old child is presented with skin involvement with myeloid sarcoma. CASE REPORT A 9-year-old male child was admitted to the Oncology Service of the hospital complaining of fever, progressive fatigue, oral petechiae with severe bleeding in the oral cavity. Bone marrow examination showed some promyelocytes...
April 13, 2018: American Journal of Case Reports
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