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Celiac osteoporosis

Hilary Jericho, Naire Sansotta, Stefano Guandalini
OBJECTIVE: To evaluate the effectiveness of the GFD on extra-intestinal symptoms in pediatric and adult celiac populations at the University of Chicago (UofC). METHODS: We conducted a retrospective chart review of the UofC Celiac Center clinic charts from January 2002 to October 2014. Demographics, serologic testing, intestinal biopsies, and extra-intestinal symptoms at presentation, 12, 24, and greater than 24 months were recorded. Extra-intestinal symptoms included: abnormal liver enzymes, arthralgia/arthritis, dermatitis herpetiformis (DH), alopecia, fatigue, headache, anemia, stomatitis, myalgias, psychiatric disorders, rashes, seizures, neuropathy, short stature, delayed puberty, osteoporosis and infertility...
October 13, 2016: Journal of Pediatric Gastroenterology and Nutrition
A Lazaridis, M E Drosou, A Fontalis, E Prousali, S E Hadwe, O Giouleme, K Petidis
INTRODUCTION: Celiac disease is an autoimmune disease of the small intestine which occurs in genetically predisposed people of all ages. A large clinical spectrum of manifestations accompanies the onset of the disease with diarrhoea, flatulence and weight loss being the most common. However, findings like osteoporosis, iron deficiency, anaemia and hypocalcaemia could also insinuate the existence of the disease. CASE PRESENTATION: We report the case of a 55-year-old man with numbness and tingling of the upper extremities due to hypocalcaemia that proved to be an uncommon case of celiac disease...
October 16, 2016: Scottish Medical Journal
Loredana Cavalli, Andrea Guazzini, Luisella Cianferotti, Simone Parri, Tiziana Cavalli, Alessia Metozzi, Francesca Giusti, Caterina Fossi, Dennis M Black, Maria Luisa Brandi
BACKGROUND: BoneTour is a campaign conducted throughout the Italian territory for the assessment of Italian people bone status and for the prevention of osteoporosis. METHODS: A total of 7305 sequential subjects of both sexes were screened, collecting clinical data through the FRAX™ questionnaire, and measuring heel bone stiffness by Quantitative Ultrasonography (QUS). The 10-year risk for hip and major osteoporotic fractures was calculated taking into account personal or family history of fragility fracture, smoking, alcohol abuse, rheumatoid arthritis, prolonged steroids assumption...
2016: BMC Musculoskeletal Disorders
Ananya Datta Mitra, Asha Gupta, Ishwarlal Jialal
The clinical presentation of celiac disease has evolved from chronic diarrhea and malnutrition to mild nutrient insufficiencies. Recently diagnosed adults with celiac disease should be assessed for micronutrient deficiencies because early institution of a gluten-free diet (GFD) prevents morbidity and reduces the incidence of gastrointestinal malignant neoplasms and osteoporosis. In this report, we present the case of a 49-year-old woman of Southeast Asian-Indian descent living in the United States who had folate insufficiency, as manifested by low serum and red blood cell (RBC) folate levels...
August 2016: Laboratory Medicine
Detlef Schuppan
Celiac disease is induced by the consumption of gluten containing cereals (wheat, spelt, barley, rye). With a prevalence of ~ 1 %, it is the most common non-infectious chronic inflammatory intestinal disease worldwide. It manifests in all age groups, either classically with abdominal pain, diarrhoea and growth failure or weight loss, more commonly with indirect consequences of malabsorption, such as anaemia and osteoporosis, or with associated autoimmune diseases like type 1 diabetes, autoimmune thyroiditis or dermatitis herpetiformis...
July 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Raimund Weitgasser, Heidemarie Abrahamian, Martin Clodi, Sandra Zlamal-Fortunat, Heinz F Hammer
Exocrine pancreatic insufficiency (EPI) in diabetic patients is frequent. Studies based on fecal elastase-1 measurement give prevalence rates of 10‒30 % of severe and 22‒56 % of moderate EPI in type 1 and rates of 5‒46 % in type 2 diabetic patients. Nevertheless, not all patients report typical symptoms like diarrhea, steatorrhea and weight loss. For noninvasive testing the determination of fecal elastase-1 has the highest sensitivity and specificity. This test should be performed at least in all symptomatic patients...
April 2016: Wiener Klinische Wochenschrift
Iwona Krela-Kaźmierczak, Aleksandra Szymczak, Liliana Łykowska-Szuber, Piotr Eder, Krzysztof Linke
Secondary osteoporosis occurs as an isolated pathology or co-exists with types I and II osteoporosis. The gastroenterologist may come across osteoporosis or osteopenia in a patient with a gastrointestinal disease. This is often a young patient in whom investigations should be carried out and appropriate treatment initiated, aimed at preventing bone fractures and the formation of the best peak bone mass. Osteoporosis occurs in patients with the following conditions: Crohn's disease, ulcerative colitis, celiac disease, post gastrectomy patients, patients with short bowel syndrome, chronic hepatitis and cirrhosis, treated with steroids (steroid-induced osteoporosis) and patients using proton pump inhibitors chronically (state of achlorhydria)...
January 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
María Belén Zanchetta, Vanesa Longobardi, Julio César Bai
More than 50% of untreated patients with celiac disease (CD) have bone loss detected by bone densitometry (dual-energy X-ray absorptiometry:DXA). Moreover, patients with CD are more likely to have osteoporosis and fragility fractures, especially of the distal radius. Although still controversial, we recommend DXA screening in all celiac disease patients, particularly in those with symptomatic CD at diagnosis and in those who present risk factors for fracture such as older age, menopausal status, previous fracture history, and familial hip fracture history...
April 2016: Current Osteoporosis Reports
Lorete M S Kotze, Thelma Skare, Antonella Vinholi, Leandro Jurkonis, Renato Nisihara
BACKGROUND: Osteoporosis (OP) is a metabolic bone illness that may complicate celiac disease (CD). It can lead to devastating consequences because of low bone mass and fragility fractures. PURPOSE: To study the OP prevalence in a group of Brazilian patients with CD and the value of a gluten free diet (GFD). METHODS: Retrospective study of celiac female patients from a single University Center followed with bone densitometries. Results from densitometry made at first visit were compared with a second study after a median time of 5 years...
February 2016: Revista Española de Enfermedades Digestivas
Lorete M S Kotze, Thelma Skare, Antonella Vinholi, Leandro Jurkonis, Renato Nisihara
BACKGROUND: Osteoporosis (OP) is a metabolic bone illness that may complicate celiac disease (CD). It can lead to devastating consequences because of low bone mass and fragility fractures. PURPOSE: To study the OP prevalence in a group of Brazilian patients with CD and the value of a gluten free diet (GFD). METHODS: Retrospective study of celiac female patients from a single University Center followed with bone densitometries. Results from densitometry made at first visit were compared with a second study after a median time of 5 years...
December 10, 2015: Revista Española de Enfermedades Digestivas
Johannes Pfeilschifter
Suitable diagnostic strategies beyond general measures of fracture prevention which allow the identification of those individuals who are likely to benefit most from medical treatment are of utmost importance for an efficient treatment of osteoporosis. Since 2003 the "Dachverband Osteologie" (DVO) provides recommendations for the diagnostics and treatment of osteoporosis in German speaking regions. The most recent update was in November 2014. The DVO guideline provides detailed recommendations for a diagnostic examination depending on age, gender, and the presence and strength of clinical risk factors...
November 2015: Deutsche Medizinische Wochenschrift
Dorottya Kocsis, Zsuzsanna Tóth, Ágnes A Csontos, Pál Miheller, Péter Pák, László Herszényi, Miklós Tóth, Zsolt Tulassay, Márk Juhász
BACKGROUND: Celiac disease, Crohn disease and ulcerative colitis are inflammatory disorders of the gastrointestinal tract with some common genetic, immunological and environmental factors involved in their pathogenesis. Several research shown that patients with celiac disease have increased risk of developing inflammatory bowel disease when compared with that of the general population. The aim of this study is to determine the prevalence of inflammatory bowel disease in our celiac patient cohort over a 15-year-long study period...
2015: BMC Gastroenterology
Louise Schøsler, Lisbet A Christensen, Christian L Hvas
OBJECTIVE: The presentation of celiac disease (CD) has changed over the past decades. We aimed to describe the incidence of CD and its complications at diagnosis in a historical cohort in a well-defined population in Denmark. METHODS: We included all patients aged 15+ years, who lived in Aarhus County, Denmark, and who were diagnosed with CD between January 2008 and August 2013. Data regarding gastrointestinal symptoms, anthropometrics, biochemistry, and bone mineral density were retrieved from patient records...
March 2016: Scandinavian Journal of Gastroenterology
Hélène Garnier-Lengliné, Nadine Cerf-Bensussan, Frank M Ruemmele
Celiac disease is an autoimmune enteropathy, triggered by ingestion of gluten in genetically predisposed individuals. Since the use of anti-transglutaminase and anti-endomysium antibodies in the early 1990s, two main groups of clinical presentation can be identified: patients with a symptomatic form of the disease, and patients with a pauci (a)-symptomatic form detected during the work-up of another autoimmune disease or due to a family history of celiac disease. The prevalence of both forms of the disease is currently estimated between 1/100 and 1/400...
October 2015: Clinics and Research in Hepatology and Gastroenterology
Dorothea Letner, Joanna Peloquin, Jacquelyn Durand, Anna Rutherford, Vijay Yajnik, Hamed Khalili, John Garber
BACKGROUND: Several lines of evidence suggest that abnormal iron homeostasis may itself play an important role in the development of celiac disease. AIM: We sought to determine whether abnormalities in iron status could be detected prior to the diagnosis of celiac disease, and to understand the relationship between altered iron indices and the natural history of celiac disease. METHODS: We conducted a case-control study at two major tertiary referral hospitals...
December 2015: Digestive Diseases and Sciences
Branka Kovačev-Zavišić, Tijana Ičin, Jovanka Novaković-Paro, Milica Medić-Stojanoska, Ivana Bajkin
INTRODUCTION: Secondary osteoporosis occurs in many diseases. Celiac disease-induced osteoporosis is the consequence of secondary hyperparathyroidism. Biochemical bone markers show predominance of bone resorption, thus making the bisphosphonates the first line therapy option. Intestinal mucosal changes are reversible on gluten-free diet. Osteoporosis reversibility is also possible, provided postmenopausal osteoporosis risk factors independent from celiac disease are not present. CASE REPORT: We presented a postmenopausal woman with at least a 10-year history of celiac disease prior to diagnosis, which had overt secondary hyperparathyroidism with insufficient status of vitamin D and a significant bone mass reduction...
January 2015: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Bijan Shahbazkhani, Najmeh Aletaha, Ahmad Khonche, Benyamin Farahvash, Reza Malekzadeh
AIM: the aim of this study was to investigate the necessity of screening for celiac disease in idiopathic osteoporotic patients. BACKGROUND: Osteopenia and osteoporosis are well-known and prevalent complications of celiac disease. However, the relative prevalence of celiac disease among osteoporotic populations is not known, and the benefit of screening for celiac disease among the osteoporotic population remains controversial. PATIENTS AND METHODS: We evaluated a total of 560 individuals, 460 with osteoporosis and 100 healthy subjects, from the rheumatology clinic in Imam Khomeini and Shariati hospital by IgA anti-tissue transglutaminase (anti-tTG) for celiac disease...
2015: Gastroenterology and Hepatology From Bed to Bench
George J Kahaly, Detlef Schuppan
BACKGROUND: Celiac disease (CD) is a small-intestinal inflammatory disease that is triggered by the ingestion of the storage proteins (gluten) of wheat, barley and rye. KEY MESSAGES: Endocrine autoimmunity is prevalent in patients with CD and their relatives. The genes that predispose to endocrine autoimmune diseases, e.g. type 1 diabetes, autoimmune thyroid diseases, and Addison's disease, i.e. DR3-DQ2 and DR4-DQ8, are also the major genetic determinants of CD, which is the best understood HLA-linked disease...
2015: Digestive Diseases
Christian Lodberg Hvas, Michael Dam Jensen, Maria Christina Reimer, Lene Buhl Riis, Jüri Johannes Rumessen, Hanne Skovbjerg, Ane Teisner, Signe Wildt
This national clinical guideline approved by the Danish Society for Gastroenterology and Hepatology describes the diagnosis and treatment of celiac disease (CD) in adults. CD is a chronic immune-mediated enteropathy of the small intestine triggered by the ingestion of gluten-containing proteins, which are found in wheat, rye, and barley. The disease prevalence is 0.5-1.0%, but CD remains under-diagnosed. The diagnosis relies on the demonstration of lymphocyte infiltration, crypt hyperplasia, and villous atrophy in duodenal biopsies...
April 2015: Danish Medical Journal
Emily M Stein, Halley Rogers, Alexa Leib, Donald J McMahon, Polly Young, Kyle Nishiyama, X Edward Guo, Suzanne Lewis, Peter H Green, Elizabeth Shane
CONTEXT: Osteoporosis is often a presenting sign of celiac disease (CD). Whether skeletal fragility in CD is associated with microarchitectural abnormalities is not known. OBJECTIVE: The objective of the study was to evaluate microarchitecture and biomechanical properties of bone in CD. DESIGN: This was a case-control study. SETTING: The study was conducted at a university hospital outpatient facility. PATIENTS: Patients included premenopausal women with newly diagnosed CD (n = 33) and healthy controls (n = 33)...
June 2015: Journal of Clinical Endocrinology and Metabolism
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